Laura Edwards

Works (7)

Updated: June 18th, 2025 21:07

2024 article

A gene edited pig model for studying LGR5+ stem cells: implications for future applications in tissue regeneration and biomedical research

Hill, A. B. T., Murphy, Y. M., Polkoff, K. M., Edwards, L., Walker, D. M., Moatti, A., … Piedrahita, J. A. (2024, June 6). Frontiers in Genome Editing, Vol. 6.

By: A. Hill n, Y. Murphy n, K. Polkoff n, L. Edwards n , D. Walker n, A. Moatti n , A. Greenbaum n, J. Piedrahita n 

author keywords: LGR5; gene edited pigs; organ stem cells; regenerative medicine; animal models
topics (OpenAlex): Pluripotent Stem Cells Research; Cancer Cells and Metastasis; Neonatal Respiratory Health Research
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Sources: Web Of Science, NC State University Libraries
Added: July 1, 2024

2024 article

Novel Porcine Model Reveals Two Distinct LGR5 Cell Types during Lung Development and Homeostasis

Polkoff, K. M., Lampe, R., Gupta, N. K., Murphy, Y., Chung, J., Carter, A., … Piedrahita, J. A. (2024, November 5). American Journal of Respiratory Cell and Molecular Biology, Vol. 72, pp. 496–509.

By: K. Polkoff n, R. Lampe n, N. Gupta  n, Y. Murphy n, J. Chung n, A. Carter n, J. Simon *, K. Gleason n ...

author keywords: pig model; LGR5; lung development; nerve fibroblasts
MeSH headings : Animals; Receptors, G-Protein-Coupled / metabolism; Receptors, G-Protein-Coupled / genetics; Lung / metabolism; Lung / embryology; Lung / cytology; Lung / growth & development; Homeostasis; Swine; Humans; Mice; Organoids / metabolism; Fibroblasts / metabolism; Epithelial Cells / metabolism; Models, Animal; Animals, Genetically Modified
topics (OpenAlex): Neonatal Respiratory Health Research; Congenital Diaphragmatic Hernia Studies; Respiratory Support and Mechanisms
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Sources: Web Of Science, NC State University Libraries
Added: May 19, 2025

2020 article

Three-dimensional imaging of intact porcine cochlea using tissue clearing and custom-built light-sheet microscopy

Moatti, A., Cai, Y., Li, C., Sattler, T., Edwards, L., Piedrahita, J., … Greenbaum, A. (2020, September 30). Biomedical Optics Express, Vol. 11, pp. 6181–6196.

By: A. Moatti n , Y. Cai  n, C. Li n, T. Sattler n, L. Edwards n , J. Piedrahita n , F. Ligler n, A. Greenbaum n

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Cell Image Analysis Techniques; Photoacoustic and Ultrasonic Imaging
TL;DR: 3D microscopic analysis was performed on an intact cochlea of newborn and juvenile pigs with a volume up to ∼ 250 mm3 using the BoneClear tissue clearing technique, which renders the bone transparent, to support the growing effort to regenerate cochlear tissues and assist with basic research to advance cures for hearing impairments. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 11, 2020

2018 journal article

Mast cells exert anti-inflammatory effects in an IL10(-/-) model of spontaneous colitis

Mediators of Inflammation.

By: E. Lennon, L. Borst , L. Edwards  & A. Moeser

Source: NC State University Libraries
Added: August 6, 2018

2017 article

Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity

Pohl, C. S., Medland, J. E., Mackey, E., Edwards, L. L., Bagley, K. D., DeWilde, M. P., … Moeser, A. J. (2017, June 1). Neurogastroenterology & Motility, Vol. 29.

By: C. Pohl*, J. Medland n, E. Mackey n, L. Edwards n , K. Bagley n, M. DeWilde*, K. Williams*, A. Moeser *

author keywords: developmental origins of health and disease; early life adversity; intestinal permeability; large animal model; mast cell; mast cell plexitis; translational research
MeSH headings : Animals; Cell Count; Colon / pathology; Diarrhea / etiology; Disease Models, Animal; Enteric Nervous System / pathology; Female; Ileum / metabolism; Ileum / pathology; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Intestines / pathology; Intestines / physiopathology; Male; Mast Cells / metabolism; Mast Cells / physiology; Stress, Psychological / complications; Sus scrofa; Tryptases / metabolism; Weaning
topics (OpenAlex): Animal Behavior and Welfare Studies; Gastrointestinal motility and disorders; Dermatology and Skin Diseases
TL;DR: Early life adversity is a risk factor for development of gastrointestinal disorders later in life and the underlying mechanisms through which ELA and sex interact to influence disease susceptibility remains poorly understood. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 article

Early life adversity in piglets induces long‐term upregulation of the enteric cholinergic nervous system and heightened, sex‐specific secretomotor neuron responses

Medland, J. E., Pohl, C. S., Edwards, L. L., Frandsen, S., Bagley, K., Li, Y., & Moeser, A. J. (2016, May 2). Neurogastroenterology & Motility, Vol. 28, pp. 1317–1329.

By: J. Medland n, C. Pohl*, L. Edwards n , S. Frandsen n, K. Bagley n, Y. Li*, A. Moeser *

author keywords: cholinergic neurons; early life adversity; enteric nervous system development; irritable bowel syndrome; porcine model
MeSH headings : Animals; Cholinergic Neurons / metabolism; Disease Models, Animal; Enteric Nervous System / metabolism; Female; Irritable Bowel Syndrome / metabolism; Male; Motor Neurons / metabolism; Sex Factors; Stress, Psychological / metabolism; Swine; Up-Regulation; Weaning
topics (OpenAlex): Gastrointestinal motility and disorders; Congenital gastrointestinal and neural anomalies; Infant Health and Development
TL;DR: A porcine model of ELA, early weaning stress (EWS), is utilized to investigate the influence of Ela on the development and function of the enteric nervous system (ENS). (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Early-life dietary spray-dried plasma influences immunological and intestinal injury responses to later-lifeSalmonellatyphimuriumchallenge

British Journal of Nutrition, 113(5), 783–793.

By: P. Boyer n, S. D'Costa n, L. Edwards n , M. Milloway n, E. Susick n, L. Borst n , S. Thakur n , J. Campbell ...

author keywords: Spray-dried plasma; Early-life nutrition; Salmonella typhimurium; Intestinal inflammation; Mucosal immunity; Intestinal permeability; Weaning
MeSH headings : Animals; Biomarkers / blood; Biomarkers / metabolism; Blood Proteins / administration & dosage; Blood Proteins / therapeutic use; Crosses, Genetic; Cytokines / blood; Cytokines / metabolism; Diet / adverse effects; Diet / veterinary; Energy Intake; Enterocolitis / immunology; Enterocolitis / microbiology; Enterocolitis / prevention & control; Enterocolitis / veterinary; Feces / microbiology; Female; Ileum / immunology; Ileum / metabolism; Ileum / microbiology; Ileum / pathology; Immunity, Mucosal; Immunotherapy / adverse effects; Immunotherapy / veterinary; Intestinal Mucosa / immunology; Intestinal Mucosa / metabolism; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Male; Salmonella Infections, Animal / immunology; Salmonella Infections, Animal / metabolism; Salmonella Infections, Animal / microbiology; Salmonella Infections, Animal / prevention & control; Salmonella typhimurium / growth & development; Salmonella typhimurium / immunology; Salmonella typhimurium / isolation & purification; Sus scrofa; Swine; Swine Diseases / immunology; Swine Diseases / metabolism; Swine Diseases / microbiology; Swine Diseases / prevention & control; Weaning; Weight Gain
topics (OpenAlex): COVID-19 Impact on Reproduction; Child Nutrition and Water Access
TL;DR: Results indicate that inclusion of SDP in PW diets can have an influence on subsequent immunological and intestinal injury responses induced by later-life S. typhimurium challenge. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

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