Leiah M. Carey

Works (3)

Updated: July 5th, 2023 15:38

2022 article

Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature

Moreno-Chicano, T., Carey, L. M., Axford, D., Beale, J. H., Doak, R. B., Duyvesteyn, H. M. E., … Hough, M. A. (2022, July 25). IUCrJ, Vol. 9, pp. 610–624.

By: T. Moreno-Chicano *, L. Carey n, D. Axford *, J. Beale *, R. Doak*, H. Duyvesteyn *, A. Ebrahim *, R. Henning * ...

Contributors: T. Moreno-Chicano *, L. Carey n, D. Axford *, J. Beale *, R. Doak*, H. Duyvesteyn *, A. Ebrahim *, R. Henning * ...

author keywords: serial femtosecond crystallography; serial synchrotron crystallography; neutron crystallography; XFELs; room temperature; metalloenzymes
topics (OpenAlex): Enzyme Structure and Function; Porphyrin Metabolism and Disorders; Hemoglobin structure and function
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16. Peace, Justice and Strong Institutions (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 29, 2022

2017 journal article

Interaction of Azole-Based Environmental Pollutants with the Coelomic Hemoglobin from Amphitrite ornata: A Molecular Basis for Toxicity

Biochemistry, 56(17), 2294–2303.

By: N. McCombs n, T. Moreno-Chicano, L. Carey n, S. Franzen n , M. Hough & R. Ghiladi n 

Contributors: N. McCombs n, T. Moreno-Chicano, L. Carey n, S. Franzen n , M. Hough & R. Ghiladi n 

MeSH headings : Amino Acid Motifs; Animals; Benzimidazoles / chemistry; Benzimidazoles / metabolism; Benzimidazoles / toxicity; Catalytic Domain; Computational Biology; Environmental Pollutants / chemistry; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / toxicity; Fungicides, Industrial / chemistry; Fungicides, Industrial / metabolism; Fungicides, Industrial / toxicity; Hemoglobins / antagonists & inhibitors; Hemoglobins / chemistry; Hemoglobins / metabolism; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Imidazoles / chemistry; Imidazoles / metabolism; Imidazoles / toxicity; Indazoles / chemistry; Indazoles / metabolism; Indazoles / toxicity; Isoenzymes / antagonists & inhibitors; Isoenzymes / chemistry; Isoenzymes / metabolism; Kinetics; Ligands; Models, Molecular; Peroxidases / antagonists & inhibitors; Peroxidases / chemistry; Peroxidases / metabolism; Pesticides / chemistry; Pesticides / metabolism; Pesticides / toxicity; Polychaeta / enzymology; Recombinant Fusion Proteins / chemistry; Recombinant Fusion Proteins / metabolism; Recombinant Proteins / chemistry; Recombinant Proteins / metabolism; Triazoles / chemistry; Triazoles / metabolism; Triazoles / toxicity
topics (OpenAlex): Biochemical effects in animals; Hemoglobin structure and function; Free Radicals and Antioxidants
TL;DR: The results demonstrate a new mechanism by which azole pollutants can potentially disrupt hemoglobin function, thereby improving the understanding of their impact on infaunal organisms in marine and aquatic environments. (via Semantic Scholar)
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Added: August 6, 2018

2016 journal article

Nonmicrobial Nitrophenol Degradation via Peroxygenase Activity of Dehaloperoxidase-Hemoglobin fromAmphitrite ornata

Biochemistry, 55(17), 2465–2478.

By: N. McCombs n, J. D’Antonio n, D. Barrios n, L. Carey n & R. Ghiladi n 

Contributors: N. McCombs n, . J. D'Antonio n, D. Barrios n, L. Carey n & R. Ghiladi n 

MeSH headings : Animals; Catalysis; Hemoglobins / metabolism; Hydrogen Peroxide / metabolism; Mixed Function Oxygenases / metabolism; Nitrophenols; Oxidation-Reduction; Oxygen / metabolism; Peroxidases / metabolism; Polychaeta / enzymology
topics (OpenAlex): Hemoglobin structure and function; Heme Oxygenase-1 and Carbon Monoxide; Metal-Catalyzed Oxygenation Mechanisms
TL;DR: The results demonstrate that there may be a much larger number of nonmicrobial enzymes that are underrepresented when it comes to understanding the degradation of persistent organic pollutants such as nitrophenols in the environment. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

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