Works (44)
Updated: August 6th, 2023 05:01
2023 journal article
A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease
FASEB JOURNAL, 37(6).
co-author countries:
United States of America 🇺🇸
author keywords: APC mutation; colorectal cancer; intestine; Lgr5; porcine; stem cell; transgenic large animal
MeSH headings : Humans; Swine; Animals; Mice; In Situ Hybridization, Fluorescence; Intestines; Stem Cells; Ileum; Colon; Coleoptera; Green Fluorescent Proteins / genetics; Receptors, G-Protein-Coupled / genetics
doi.org (publisher)
Sources: Web Of Science, ORCID
Added: June 12, 2023
2023 review
Biomarkers of Intestinal Injury in Colic
[Review of ]. ANIMALS, 13(2).
co-author countries:
United States of America 🇺🇸
author keywords: colic; intestine; ischemia; biomarker; acute phase protein; cytokine
Sources: ORCID, Web Of Science
Added: January 10, 2023
2023 article
Changes in equine intestinal stem/progenitor cell number at resection margins in cases of small intestinal strangulation
Veerasammy, B., Gonzalez, G., Baez-Ramos, P., Schaaf, C. R., Stewart, A. S., Ludwig, E. K., … Gonzalez, L. M. (2023, February 9). EQUINE VETERINARY JOURNAL, Vol. 2.
co-author countries:
United States of America 🇺🇸
author keywords: horse; immunofluorescence; intestine; Ki67; small intestinal strangulation; stem cell
Sources: ORCID, Web Of Science
Added: January 31, 2023
2023 article
Comparison of the Effects of Normothermic Machine Perfusion and Cold Storage Preservation on Porcine Intestinal Allograft Regenerative Potential and Viability
Ludwig, E., Abraham, N., McKinney, C., Freund, J., Stewart, A., Garman, K., … Gonzalez, L. (2023, July). TRANSPLANTATION, Vol. 107, pp. 25–25.
co-author countries:
United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: July 31, 2023
2022 journal article
Culture of equine intestinal epithelial stem cells after delayed tissue storage for future applications
BMC VETERINARY RESEARCH, 18(1).
co-author countries:
United States of America 🇺🇸
author keywords: Horse; Stem cell; 3D culture; Organoid; Enteroid; Intestine; Storage
MeSH headings : Animals; Cryopreservation / veterinary; Epithelial Cells / cytology; Horses; Intestines / cytology; Stem Cells / cytology; Time Factors; Cells, Cultured; Intestinal Diseases / therapy; Intestinal Diseases / veterinary
Sources: Web Of Science, ORCID
Added: January 30, 2023
2022 journal article
Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(18).
co-author countries:
United States of America 🇺🇸
author keywords: PLAC8; coronavirus; CRISPR; swine acute diarrhea syndrome coronavirus
MeSH headings : Alphacoronavirus / genetics; Animals; Clustered Regularly Interspaced Short Palindromic Repeats / genetics; Coronavirus Infections / epidemiology; Swine; Swine Diseases
Sources: Web Of Science, ORCID
Added: June 13, 2022
2022 journal article
Orthotopic Transplantation of the Full-length Porcine Intestine After Normothermic Machine Perfusion
TRANSPLANTATION DIRECT, 8(11).
co-author countries:
United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: October 31, 2022
2022 review
Use of Translational, Genetically Modified Porcine Models to Ultimately Improve Intestinal Disease Treatment
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 9.
co-author countries:
United States of America 🇺🇸
author keywords: cystic fibrosis; colorectal cancer; ischemia-reperfusion injury; genetically altered models; intestinal disease; translational porcine model; stem cell reporter model
Sources: Web Of Science, ORCID
Added: June 13, 2022
2021 journal article
HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 321(5), G588–G602.
co-author countries:
United States of America 🇺🇸
author keywords: epithelial repair; HOPX; ischemia; large animal models; stem cell
MeSH headings : Animals; Cell Proliferation; Disease Models, Animal; Epithelial Cells / metabolism; Epithelial Cells / pathology; Female; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Male; Mesenteric Ischemia / genetics; Mesenteric Ischemia / metabolism; Mesenteric Ischemia / pathology; Phenotype; Re-Epithelialization; Severity of Illness Index; Stem Cells / metabolism; Stem Cells / pathology; Sus scrofa; Tissue Culture Techniques
Sources: ORCID, Web Of Science
Added: November 3, 2021
2021 journal article
Porcine small intestinal organoids as a model to explore ETEC-host interactions in the gut
VETERINARY RESEARCH, 52(1).
co-author countries:
Belgium 🇧🇪
author keywords: Intestinal stem cells; Enteroids; ETEC; Swelling assay; Pig
MeSH headings : Animals; Enterotoxigenic Escherichia coli / physiology; Enterotoxins / toxicity; Escherichia coli Infections / microbiology; Escherichia coli Infections / physiopathology; Escherichia coli Infections / veterinary; Host-Pathogen Interactions; Intestine, Small / microbiology; Intestine, Small / physiopathology; Organoids / microbiology; Organoids / physiopathology; Sus scrofa; Swine; Swine Diseases / microbiology; Swine Diseases / physiopathology
Sources: Web Of Science, ORCID
Added: July 19, 2021
2021 article
Porcine small intestinal organoids as a model to explore ETEC-host interactions in the gut (vol 52, 94, 2021)
Vermeire, B., Gonzalez, L. M., Jansens, R. J. J., Cox, E., & Devriendt, B. (2021, August 3). VETERINARY RESEARCH, Vol. 52.
co-author countries:
Belgium 🇧🇪
Sources: Web Of Science, ORCID
Added: August 9, 2021
2020 journal article
Enteroendocrine Progenitor Cell-Enriched mir-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 9(3), 447–464.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
author keywords: miR-7; Enteroendocrine Lineage; Small Intestine; Enteroid; Proliferation
MeSH headings : Animals; Cell Lineage / genetics; Cell Proliferation / genetics; Cells, Cultured; Computational Biology; Enteroendocrine Cells / physiology; ErbB Receptors / metabolism; Feeding Behavior / physiology; Female; Inhibitor of Apoptosis Proteins / genetics; Inhibitor of Apoptosis Proteins / metabolism; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Male; Mice; Mice, Transgenic; MicroRNAs / metabolism; Models, Animal; Organoids; Primary Cell Culture; RNA-Seq; Signal Transduction / genetics; Single-Cell Analysis; Stem Cells / physiology
Sources: Web Of Science, ORCID
Added: April 6, 2020
2020 journal article
Prognostic value of colonic and peripheral venous lactate measurements in horses with large colon volvulus
Veterinary Surgery, 1.
co-author countries:
United States of America 🇺🇸
MeSH headings : Animals; Biopsy / veterinary; Blood Gas Analysis / veterinary; Colon / pathology; Female; Hemorrhage / pathology; Horse Diseases / blood; Horse Diseases / diagnosis; Horse Diseases / therapy; Horses; Intestinal Volvulus / blood; Intestinal Volvulus / diagnosis; Intestinal Volvulus / therapy; Intestinal Volvulus / veterinary; Lactates / blood; Male; Prognosis; Prospective Studies
Source: ORCID
Added: January 10, 2020
2019 journal article
Preservation of reserve intestinal epithelial stem cells following severe ischemic injury
American Journal of Physiology-Gastrointestinal and Liver Physiology, 316(4), G482–G494.
co-author countries:
United States of America 🇺🇸
author keywords: intestine; ischemia reperfusion injury; large animal model; reserve stem cells; stem cell
MeSH headings : Animals; Apoptosis; Cell Proliferation / physiology; Cell Self Renewal / physiology; Cell Survival / physiology; Disease Models, Animal; Homeodomain Proteins / metabolism; Intestinal Mucosa / blood supply; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Ischemia / metabolism; Receptors, G-Protein-Coupled / metabolism; Reperfusion Injury / metabolism; Swine
Sources: ORCID, Crossref
Added: March 16, 2019
2018 journal article
Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair
PLOS ONE, 13(8), e0200674.
co-author countries:
United States of America 🇺🇸
Contributors: A. Ziegler n , T. Pridgen n, J. Mills n, n , L. Van Landeghem n, J. Odle n , A. Blikslager n
Ed(s): J. Karhausen
MeSH headings : Animals; Animals, Newborn; Cells, Cultured; Epithelium / injuries; Epithelium / pathology; Intestinal Diseases / physiopathology; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Ischemia / physiopathology; Jejunum / injuries; Jejunum / physiology; Recovery of Function; Swine; Vascular Diseases / pathology; Vascular Diseases / prevention & control
Sources: Web Of Science, ORCID, Crossref
Added: October 16, 2018
2018 journal article
Equine intestinal mucosal pathobiology
Annual Review of Animal Biosciences, Vol 6, 6, 157–175.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Gross Morphometry, Histomorphometry, and Immunohistochemistry Confirm Early and Persistent Jejunal Crypt Hyperplasia in Poults with Enteritis and Depressed Growth
Avian Diseases, 62(2), 163–170.
co-author countries:
United States of America 🇺🇸
author keywords: turkey; poult enteritis; immunohistochemistry; histomorphometry; gross morphometry; crypt hyperplasia; growth; gut health
MeSH headings : Animals; Caspase 3 / metabolism; Chickens; Enteritis / metabolism; Enteritis / pathology; Enteritis / physiopathology; Enteritis / veterinary; Female; Histones / metabolism; Hyperplasia / metabolism; Hyperplasia / pathology; Hyperplasia / physiopathology; Hyperplasia / veterinary; Immunohistochemistry; Jejunum / anatomy & histology; Jejunum / growth & development; Jejunum / metabolism; Male; North Carolina; Phosphorylation; Poultry Diseases / metabolism; Poultry Diseases / pathology; Poultry Diseases / physiopathology; Turkeys / anatomy & histology; Turkeys / growth & development
Sources: Crossref, ORCID
Added: August 20, 2019
2018 journal article
Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
Journal of Visualized Experiments, 5(135).
author keywords: Medicine; Issue 135; Porcine; intestine; ischemia-reperfusion; stem cell; enteroid; organoid
MeSH headings : Animals; Cell Culture Techniques / methods; Disease Models, Animal; Humans; Intestine, Small / cytology; Intestine, Small / metabolism; Intestine, Small / pathology; Ischemia / etiology; Mice; Stem Cells / metabolism; Swine
Sources: Web Of Science, ORCID, Crossref
Added: October 16, 2018
2018 article
Large colon volvulus: The continued conundrum
Gonzalez, L. M. (2018, June). EQUINE VETERINARY EDUCATION, Vol. 30, pp. 312–314.
co-author countries:
United States of America 🇺🇸
author keywords: horse; foal; large colon; volvulus; colic; surgery
Sources: Web Of Science, ORCID
Added: August 6, 2018
2018 journal article
Veterinary Medical Students' Motivations for Exercise
Journal of Veterinary Medical Education, 45(3), 367–373.
co-author countries:
United States of America 🇺🇸
author keywords: academic affairs; curriculum; environment; outcomes; psychology; public health; student affairs; student health and well-being
MeSH headings : Adult; Animals; Education, Veterinary; Exercise; Female; Humans; Male; Motivation; North Carolina; Students, Medical / psychology; Surveys and Questionnaires; Young Adult
Sources: Web Of Science, Crossref, ORCID
Added: October 19, 2018
2018 journal article
Veterinary Medical Students' Motivations for Exercise
Journal of Veterinary Medical Education, 1, 1–7.
co-author countries:
United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 11, 2019
2017 journal article
A Novel Inflammation-Activated Drug Delivery System Using Self-Assembling Hydrogel Doubles Esophageal Dwell Time in an Esophageal Injury Porcine Model
Gastroenterology, 152(5), S859–S860.
Sources: Crossref, ORCID
Added: February 5, 2020
2017 journal article
Advanced three-dimensional culture of equine intestinal epithelial stem cells
Equine Veterinary Journal, 50(2), 241–248.
co-author countries:
United States of America 🇺🇸
author keywords: horse; stem cell; 3D culture; intestine; enteroid; organoid
MeSH headings : Animals; Cell Culture Techniques / veterinary; Cell Differentiation; Female; Horses; Intestinal Mucosa / cytology; Male; Models, Biological; Stem Cells / physiology
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2017 review
Alterations in Intestinal Permeability: The Role of the "Leaky Gut" in Health and Disease
[Review of ]. JOURNAL OF EQUINE VETERINARY SCIENCE, 52, 10–22.
co-author countries:
United States of America 🇺🇸
author keywords: Horse; Intestinal permeability; Leaky gut; Barrier function; Decreased performance
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Ductular and proliferative response of esophageal submucosal glands in a porcine model of esophageal injury and repair
American Journal of Physiology-Gastrointestinal and Liver Physiology, 313(3), G180–G191.
co-author countries:
United States of America 🇺🇸
author keywords: esophagus; injury; repair; esophageal submucosal gland; proliferation
MeSH headings : Active Transport, Cell Nucleus; Animals; Cell Proliferation / physiology; Esophageal Diseases / pathology; Esophagus / cytology; Esophagus / injuries; Female; Gene Expression Regulation / physiology; Humans; Male; SOX9 Transcription Factor / genetics; SOX9 Transcription Factor / metabolism; Staining and Labeling; Swine
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2017 journal article
Porcine Esophageal Submucosal Gland Culture Model Shows Capacity for Proliferation and Differentiation
Cellular and Molecular Gastroenterology and Hepatology, 4(3), 385–404.
co-author countries:
United States of America 🇺🇸
author keywords: Esophagus; Barrett's Esophagus; 3D Culture; Acinar Ductal Metaplasia; Adult Stem Cell
Sources: Crossref, ORCID
Added: August 18, 2019
2017 journal article
Protein biomarker of cell proliferation determines survival to discharge in cases of equine large colon volvulus
Equine Veterinary Journal, 50(4), 452–456.
co-author countries:
United States of America 🇺🇸
author keywords: horse; large colon volvulus; immunohistochemistry; phospho-histone H3; intestine; stem cell
MeSH headings : Animals; Biomarkers; Cell Proliferation / physiology; Cohort Studies; Colonic Diseases / veterinary; Female; Gene Expression Regulation; Horse Diseases / blood; Horses; Intestinal Volvulus / metabolism; Intestinal Volvulus / pathology; Intestinal Volvulus / veterinary; Male; ROC Curve; Retrospective Studies; Survival Analysis
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2017 journal article
Supplementation of Maternal Diets with Docosahexaenoic Acid and Methylating Vitamins Impacts Growth and Development of Fetuses from Malnourished Gilts
Current Developments in Nutrition, 2(3).
co-author countries:
United States of America 🇺🇸
Contributors: H. Lima n, X. Lin n, S. Jacobi n, C. Man n, J. Sommer n, W. Flowers n, A. Blikslager n , n , J. Odle n
author keywords: choline; B-vitamins; epigenetics; intrauterine growth restriction; nutrient restriction; low birth weight
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2016 journal article
27 AN IMPROVED LARGE ANIMAL MODEL FOR THE STUDY OF ADULT STEM CELLS
Reproduction, Fertility and Development, 28(2), 143.
co-author countries:
United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 5, 2020
2016 journal article
An Evaluation of the Psychometric Properties of an Advising Survey for Medical and Professional Program Students
Journal of Educational and Developmental Psychology, 6(1), 195.
Sources: Crossref, ORCID
Added: February 11, 2019
2016 chapter
Intestinal Stem Cells
In A. T. Blikslager, N. A. White, J. N. Moore, & T. S. Mair (Eds.), Equine Acute Abdomen (3rd ed.). Hoboken, NJ: Wiley & Sons, Inc.
Ed(s): A. Blikslager, N. White, J. Moore & T. Mair
Source: NC State University Libraries
Added: September 11, 2019
2016 chapter
Intestinal Viability
In A. T. Blikslager, N. A. White, J. N. Moore, & T. S. Mair (Eds.), Equine Acute Abdomen (3rd ed., p. 570). Hoboken, NJ: Wiley & Sons, Inc.
Ed(s): A. Blikslager, N. White, J. Moore & T. Mair
Source: NC State University Libraries
Added: September 11, 2019
2016 journal article
Large Animal Models: The Key to Translational Discovery in Digestive Disease Research
Cellular and Molecular Gastroenterology and Hepatology, 2(6), 716–724.
co-author countries:
United States of America 🇺🇸
author keywords: Pig; Ischemia/Reperfusion Injury; Mucosal Repair; Tight Junction
Sources: Crossref, ORCID
Added: July 20, 2019
2016 journal article
Mo1253 Ductular and Proliferative Response of Esophageal Submucosal Glands in a Porcine Model of Esophageal Injury and Repair
Gastroenterology, 150(4), S679–S680.
Sources: Crossref, ORCID
Added: February 5, 2020
2016 journal article
Mo1298 Critical Contribution of Intestinal Stem Cells in the Repair of Ischemia Reperfusion Injury
Gastroenterology, 150(4), S691.
Sources: Crossref, ORCID
Added: February 5, 2020
2015 journal article
Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research
American Journal of Physiology-Gastrointestinal and Liver Physiology, 308(2), G63–G75.
co-author countries:
United States of America 🇺🇸
Contributors: n , A. Moeser n & A. Blikslager n
author keywords: animal model; intestine; ischemia; mucosal injury; reperfusion
MeSH headings : Animals; Disease Models, Animal; Humans; Intestines / injuries; Intestines / pathology; Ischemia / complications; Ischemia / pathology; Oxygen / metabolism; Reperfusion Injury / complications; Reperfusion Injury / metabolism; Reperfusion Injury / pathology; Translational Research, Biomedical / methods
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2015 journal article
Characterization of discrete equine intestinal epithelial cell lineages
American Journal of Veterinary Research, 76(4), 358–366.
Contributors: * , L. Kinnin & A. Blikslager*
MeSH headings : Animals; Cell Lineage; Colic / pathology; Colic / veterinary; Epithelial Cells / cytology; Female; Horse Diseases / pathology; Horses; Intestinal Mucosa / cytology
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2015 journal article
Porcine models of digestive disease: the future of large animal translational research
Translational Research, 166(1), 12–27.
co-author countries:
United States of America 🇺🇸
Contributors: n , A. Moeser n & A. Blikslager n
MeSH headings : Animals; Animals, Genetically Modified; Digestive System Diseases / etiology; Digestive System Diseases / physiopathology; Disease Models, Animal; Enterocolitis, Necrotizing / etiology; Gastrointestinal Tract / anatomy & histology; Gastrointestinal Tract / blood supply; Gastrointestinal Tract / injuries; Humans; Intestines / transplantation; Reperfusion Injury / etiology; Short Bowel Syndrome / etiology; Short Bowel Syndrome / therapy; Species Specificity; Stress, Psychological / complications; Swine; Translational Research, Biomedical; Wound Healing
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2015 article
The mother of a gut cell: Intestinal epithelial stem cells
Gonzalez, L. M. (2015, November). EQUINE VETERINARY EDUCATION, Vol. 27, pp. 559–560.
co-author countries:
United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Mo1960 Intestinal Epithelial Cells Expressing Biomarkers of Crypt Base Columnar or Reserve Stem Cells Show Differential Resistance to Ischemia-Reperfusion Injury
Gastroenterology, 146(5), S-702.
Sources: Crossref, ORCID
Added: February 5, 2020
2014 journal article
Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013
Equine Veterinary Journal, 47(3), 279–284.
co-author countries:
United States of America 🇺🇸
Contributors: n , C. Fogle n , W. Baker, F. Hughes*, J. Law n, A. Motsinger-Reif n, A. Blikslager n
author keywords: horse; large colon volvulus; strangulation; pelvic flexure; surgery
MeSH headings : Animals; Biopsy; Colon / pathology; Hemorrhage / pathology; Hemorrhage / veterinary; Horse Diseases / surgery; Horses; Intestinal Volvulus / pathology; Intestinal Volvulus / surgery; Intestinal Volvulus / veterinary; Logistic Models; Retrospective Studies
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2013 journal article
Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration
PLoS One, 8(6).
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Su1099 A Translational Porcine Model of Intestinal Stem Cells
Gastroenterology, 144(5), S-398.
Sources: Crossref, ORCID
Added: February 5, 2020
2010 journal article
MRI FEATURES OF METACARPO(TARSO)PHALANGEAL REGION LAMENESS IN 40 HORSES
Veterinary Radiology & Ultrasound, 51(4), 404–414.
co-author countries:
United States of America 🇺🇸
author keywords: equine; fetlock; high-field magnetic resonance imaging; metacarpophalangeal joint; metatarsophalangeal joint
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018
