Works (46)

Updated: June 8th, 2024 05:34

2023 journal article

45: Comparison of the Effects of Normothermic Machine Perfusion and Cold Storage Preservation on Porcine Intestinal Allograft Regenerative Potential and Viability

Transplantation, 107(7S), 25–25.

By: E. Ludwig n, N. Abraham*, C. McKinney n, J. Freund n, A. Stewart n, K. Garman*, A. Barbas*, D. Sudan*, L. Gonzalez n

Sources: Web Of Science, NC State University Libraries, Crossref
Added: July 31, 2023

2023 journal article

A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease

FASEB JOURNAL, 37(6).

By: C. Schaaf n, K. Polkoff n, A. Carter n, A. Stewart n, B. Sheahan n, J. Freund n, J. Ginzel*, J. Snyder* ...

author keywords: APC mutation; colorectal cancer; intestine; Lgr5; porcine; stem cell; transgenic large animal
MeSH headings : Humans; Swine; Animals; Mice; In Situ Hybridization, Fluorescence; Intestines; Stem Cells; Ileum; Colon; Coleoptera; Green Fluorescent Proteins / genetics; Receptors, G-Protein-Coupled / genetics
TL;DR: This study validates ISC isolation in a new porcine Leucine Rich Repeat Containing G Protein‐Coupled Receptor 5 (LGR5) reporter line and demonstrates the use of these pigs as a novel colorectal cancer model. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: June 12, 2023

2023 journal article

Biomarkers of Intestinal Injury in Colic

Animals, 13(2), 227.

By: E. Ludwig n, K. Hobbs n, C. McKinney-Aguirre & L. Gonzalez n

author keywords: colic; intestine; ischemia; biomarker; acute phase protein; cytokine
TL;DR: Ultimately, based on this review, L-lactate continues to be the most reliable marker for intestinal ischemia during colic, and further exploration of the biomarkers discussed in this review may provide the key to accelerated identification, intervention, and better outcomes for horses suffering from severe colic. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: January 10, 2023

2023 journal article

Changes in equine intestinal stem/progenitor cell number at resection margins in cases of small intestinal strangulation

Equine Veterinary Journal, 55(6), 995–1002.

By: B. Veerasammy n, G. Gonzalez n, P. Báez‐Ramos n, C. Schaaf n, A. Stewart n, E. Ludwig n, C. McKinney‐Aguirre, J. Freund n, J. Robertson n, L. Gonzalez n

author keywords: horse; immunofluorescence; intestine; Ki67; small intestinal strangulation; stem cell
TL;DR: Proliferating cell and ISC numbers may be associated with case outcome, and associations between biomarker expression and the number of preoperative risk factors and postoperative complications negatively related to outcome were determined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: January 31, 2023

2023 journal article

Comparison of the effects of normothermic machine perfusion and cold storage preservation on porcine intestinal allograft regenerative potential and viability

American Journal of Transplantation, 24(4), 564–576.

By: E. Ludwig n, N. Abraham*, C. Schaaf n, C. McKinney n, J. Freund n, A. Stewart n, B. Veerasammy n, M. Thomas n ...

author keywords: intestinal transplantation; normothermic machine perfusion; cold storage; ischemia-reperfusion injury; intestinal stem cells; preservation injury
TL;DR: Normothermic machine perfusion preservation of kidney and liver allografts minimizes CS-associated ischemia-reperfusion injury and appears to reduce IRI and improve graft regeneration with improved ISC viability and proliferation. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: December 28, 2023

2023 journal article

Respondents to an American College of Veterinary Surgeons diplomate survey support the promotion of diversity, equity, and inclusion initiatives

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 261(12), 1847–1852.

By: L. Gonzalez n, A. Stampley*, D. Marcellin-Little* & A. Kedrowicz n

author keywords: DEI; demographic survey; diversity; equity; and inclusion; American College of Veterinary Surgeons; ACVS
TL;DR: Findings suggested that the majority of ACVS respondents are supportive of DEI efforts, and this study serves as an objective analysis that can be reassessed in the future to determine the success of such initiatives. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 19, 2024

2022 journal article

Culture of equine intestinal epithelial stem cells after delayed tissue storage for future applications

BMC VETERINARY RESEARCH, 18(1).

By: A. Stewart n, C. Schaaf n, B. Veerasammy n, J. Freund n & L. Gonzalez n

author keywords: Horse; Stem cell; 3D culture; Organoid; Enteroid; Intestine; Storage
MeSH headings : Animals; Cryopreservation / veterinary; Epithelial Cells / cytology; Horses; Intestines / cytology; Stem Cells / cytology; Time Factors; Cells, Cultured; Intestinal Diseases / therapy; Intestinal Diseases / veterinary
TL;DR: Equine ISCs can be isolated and cultured after prolonged tissue storage and this suggests that ISCs could be isolated for several days from samples properly stored after procedures, including surgery or necropsy, and used to create ISC repositories for study or therapy of equine intestinal diseases. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 30, 2023

2022 journal article

Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(18).

By: L. Tse*, R. Meganck*, K. Araba*, B. Yount*, K. Shaffer*, Y. Hou*, J. Munt*, L. Adams* ...

author keywords: PLAC8; coronavirus; CRISPR; swine acute diarrhea syndrome coronavirus
MeSH headings : Alphacoronavirus / genetics; Animals; Clustered Regularly Interspaced Short Palindromic Repeats / genetics; Coronavirus Infections / epidemiology; Swine; Swine Diseases
TL;DR: Using genomewide CRISPR knockout screening, the placenta-associated 8 protein (PLAC8) is identified as an essential host factor for SADS-CoV infection, uncovering a novel antiviral target for CoV infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 13, 2022

2022 journal article

Orthotopic Transplantation of the Full-length Porcine Intestine After Normothermic Machine Perfusion

Transplantation Direct, 8(11), e1390.

By: N. Abraham*, E. Ludwig n, C. Schaaf n, B. Veerasammy n, A. Stewart n, C. McKinney n, J. Freund n, J. Brassil ...

TL;DR: Development and optimization of machine perfusion preservation of small intestine and successful transplantation of intestinal allografts in a porcine model are reported. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: October 31, 2022

2022 review

Use of Translational, Genetically Modified Porcine Models to Ultimately Improve Intestinal Disease Treatment

[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 9.

By: C. Schaaf n & L. Gonzalez n

author keywords: cystic fibrosis; colorectal cancer; ischemia-reperfusion injury; genetically altered models; intestinal disease; translational porcine model; stem cell reporter model
TL;DR: Recent advances and increased availability of gene editing technologies has led to both novel use of large animal models in clinically relevant intestinal disease research and improved testing of potential therapeutics for these diseases. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: June 13, 2022

2021 journal article

HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 321(5), G588–G602.

By: A. Stewart n, C. Schaaf n, J. Luff n, J. Freund n, T. Becker*, S. Tufts n, J. Robertson n, L. Gonzalez n

author keywords: epithelial repair; HOPX; ischemia; large animal models; stem cell
MeSH headings : Animals; Cell Proliferation; Disease Models, Animal; Epithelial Cells / metabolism; Epithelial Cells / pathology; Female; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Male; Mesenteric Ischemia / genetics; Mesenteric Ischemia / metabolism; Mesenteric Ischemia / pathology; Phenotype; Re-Epithelialization; Severity of Illness Index; Stem Cells / metabolism; Stem Cells / pathology; Sus scrofa; Tissue Culture Techniques
TL;DR: It is demonstrated that during early in vivo recovery, injury-resistant HOPX+cells maintain quiescence, suggesting that HopX may serve a functional role in ISC mediated regeneration after injury and could be a target to control ISC proliferation. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 3, 2021

2021 journal article

Porcine small intestinal organoids as a model to explore ETEC-host interactions in the gut

VETERINARY RESEARCH, 52(1).

author keywords: Intestinal stem cells; Enteroids; ETEC; Swelling assay; Pig
MeSH headings : Animals; Enterotoxigenic Escherichia coli / physiology; Enterotoxins / toxicity; Escherichia coli Infections / microbiology; Escherichia coli Infections / physiopathology; Escherichia coli Infections / veterinary; Host-Pathogen Interactions; Intestine, Small / microbiology; Intestine, Small / physiopathology; Organoids / microbiology; Organoids / physiopathology; Sus scrofa; Swine; Swine Diseases / microbiology; Swine Diseases / physiopathology
TL;DR: It is reported that porcine enteroids respond in a similar manner as in vivo gut tissues to enterotoxins derived from enteringotoxigenic Escherichia coli, an enteric pathogen causing postweaning diarrhoea in piglets. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 19, 2021

2021 article

Porcine small intestinal organoids as a model to explore ETEC-host interactions in the gut (vol 52, 94, 2021)

Vermeire, B., Gonzalez, L. M., Jansens, R. J. J., Cox, E., & Devriendt, B. (2021, August 3). VETERINARY RESEARCH, Vol. 52.

Sources: Web Of Science, NC State University Libraries
Added: August 9, 2021

2020 journal article

Enteroendocrine Progenitor Cell-Enriched mir-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 9(3), 447–464.

By: A. Singh*, Y. Hung*, M. Shanahan*, M. Kanke*, A. Bonfini*, M. Dame*, M. Biraud n, B. Peck* ...

author keywords: miR-7; Enteroendocrine Lineage; Small Intestine; Enteroid; Proliferation
MeSH headings : Animals; Cell Lineage / genetics; Cell Proliferation / genetics; Cells, Cultured; Computational Biology; Enteroendocrine Cells / physiology; ErbB Receptors / metabolism; Feeding Behavior / physiology; Female; Inhibitor of Apoptosis Proteins / genetics; Inhibitor of Apoptosis Proteins / metabolism; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Male; Mice; Mice, Transgenic; MicroRNAs / metabolism; Models, Animal; Organoids; Primary Cell Culture; RNA-Seq; Signal Transduction / genetics; Single-Cell Analysis; Stem Cells / physiology
TL;DR: This study demonstrates for the first time that EEC progenitor cell-enriched miR-7 is altered by dietary perturbations and that it regulates growth in enteroids via intact Xiap and Egfr signaling. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 6, 2020

2020 journal article

Prognostic value of colonic and peripheral venous lactate measurements in horses with large colon volvulus

Veterinary Surgery.

By: K. Orr*, W. Baker*, T. Lynch*, F. Hughes*, C. Clark*, D. Slone*, C. Fogle n, L. Gonzalez n

MeSH headings : Animals; Biopsy / veterinary; Blood Gas Analysis / veterinary; Colon / pathology; Female; Hemorrhage / pathology; Horse Diseases / blood; Horse Diseases / diagnosis; Horse Diseases / therapy; Horses; Intestinal Volvulus / blood; Intestinal Volvulus / diagnosis; Intestinal Volvulus / therapy; Intestinal Volvulus / veterinary; Lactates / blood; Male; Prognosis; Prospective Studies
TL;DR: Peripheral lactate values, histomorphometric measures of I:C ratio, and hemorrhage score provided prognostic information that could help guide recommendations made to owners in predicting case outcome in the operative and immediately postoperative period. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: ORCID
Added: January 10, 2020

2019 journal article

Preservation of reserve intestinal epithelial stem cells following severe ischemic injury

American Journal of Physiology-Gastrointestinal and Liver Physiology, 316(4), G482–G494.

By: L. Gonzalez n, A. Stewart n, J. Freund n, C. Kucera n, C. Dekaney n, S. Magness n, A. Blikslager n

author keywords: intestine; ischemia reperfusion injury; large animal model; reserve stem cells; stem cell
MeSH headings : Animals; Apoptosis; Cell Proliferation / physiology; Cell Self Renewal / physiology; Cell Survival / physiology; Disease Models, Animal; Homeodomain Proteins / metabolism; Intestinal Mucosa / blood supply; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Ischemia / metabolism; Receptors, G-Protein-Coupled / metabolism; Reperfusion Injury / metabolism; Swine
TL;DR: Data indicate that Hopx+ cells are resistant to injury and are the likely source of epithelial renewal following prolonged ischemic injury, and it is therefore possible that targeting reserve stem cells will lead to new therapies for patients with severe intestinal injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: March 16, 2019

2018 journal article

Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair

PLOS ONE, 13(8), e0200674.

By: A. Ziegler n, T. Pridgen n, J. Mills n, L. Gonzalez n, L. Van Landeghem n, J. Odle n, A. Blikslager n

Contributors: A. Ziegler n, T. Pridgen n, J. Mills n, L. Gonzalez n, L. Van Landeghem n, J. Odle n, A. Blikslager n

Ed(s): J. Karhausen

MeSH headings : Animals; Animals, Newborn; Cells, Cultured; Epithelium / injuries; Epithelium / pathology; Intestinal Diseases / physiopathology; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Ischemia / physiopathology; Jejunum / injuries; Jejunum / physiology; Recovery of Function; Swine; Vascular Diseases / pathology; Vascular Diseases / prevention & control
TL;DR: Findings support the hypothesis that a defect in mucosal repair in neonates is due to immature repair mechanisms within the mucosal compartment, and ex vivo exogenous application of injured juvenile mucosal homogenate produced a significant increase in TEER and enhanced histological restitution. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 16, 2018

2018 journal article

Equine intestinal mucosal pathobiology

Annual Review of Animal Biosciences, Vol 6, 6, 157–175.

By: A. Blikslager & L. Gonzalez

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Gross Morphometry, Histomorphometry, and Immunohistochemistry Confirm Early and Persistent Jejunal Crypt Hyperplasia in Poults with Enteritis and Depressed Growth

Avian Diseases, 62(2), 163–170.

By: O. Fletcher n, R. Mansell n, M. Martin n, L. Borst n, H. Barnes n & L. Gonzalez n

author keywords: turkey; poult enteritis; immunohistochemistry; histomorphometry; gross morphometry; crypt hyperplasia; growth; gut health
MeSH headings : Animals; Caspase 3 / metabolism; Chickens; Enteritis / metabolism; Enteritis / pathology; Enteritis / physiopathology; Enteritis / veterinary; Female; Histones / metabolism; Hyperplasia / metabolism; Hyperplasia / pathology; Hyperplasia / physiopathology; Hyperplasia / veterinary; Immunohistochemistry; Jejunum / anatomy & histology; Jejunum / growth & development; Jejunum / metabolism; Male; North Carolina; Phosphorylation; Poultry Diseases / metabolism; Poultry Diseases / pathology; Poultry Diseases / physiopathology; Turkeys / anatomy & histology; Turkeys / growth & development
TL;DR: It is confirmed that enteritis, in the absence of clinical signs, and depressed growth in turkey poults begins by day 7, can be identified microscopically, persists for at least 35 days, is associated with lower processing weights, and has a profound negative effect on turkey growth. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 20, 2019

2018 journal article

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Journal of Visualized Experiments, 5(135).

By: A. Stieler Stewart n, J. Freund n, A. Blikslager n & L. Gonzalez n

author keywords: Medicine; Issue 135; Porcine; intestine; ischemia-reperfusion; stem cell; enteroid; organoid
MeSH headings : Animals; Cell Culture Techniques / methods; Disease Models, Animal; Humans; Intestine, Small / cytology; Intestine, Small / metabolism; Intestine, Small / pathology; Ischemia / etiology; Mice; Stem Cells / metabolism; Swine
TL;DR: By utilizing a porcine model, a protocol is established in which segmental loops of intestinal ischemia can be created within a single animal, enabling the study of differing time points of ischemic injury and repair in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: October 16, 2018

2018 article

Large colon volvulus: The continued conundrum

Gonzalez, L. M. (2018, June). EQUINE VETERINARY EDUCATION, Vol. 30, pp. 312–314.

By: L. Gonzalez n

author keywords: horse; foal; large colon; volvulus; colic; surgery
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

Veterinary Medical Students' Motivations for Exercise

Journal of Veterinary Medical Education, 45(3), 367–373.

By: K. Royal n, S. Hunt n, L. Gonzalez n, G. Lewbart n & K. Bailey n

author keywords: academic affairs; curriculum; environment; outcomes; psychology; public health; student affairs; student health and well-being
MeSH headings : Adult; Animals; Education, Veterinary; Exercise; Female; Humans; Male; Motivation; North Carolina; Students, Medical / psychology; Surveys and Questionnaires; Young Adult
TL;DR: This study is the first to explore what motivates veterinary medical students to exercise given their unique situational and environmental factors and it is the authors' hope that the findings will help identify exercise-related wellness interventions that could be implemented in veterinary medical schools. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: October 19, 2018

2018 journal article

Veterinary Medical Students' Motivations for Exercise

Journal of Veterinary Medical Education, 1, 1–7.

By: K. Royal n, S. Hunt n, L. Gonzalez n, G. Lewbart n & K. Bailey n

TL;DR: This study is the first to explore what motivates veterinary medical students to exercise given their unique situational and environmental factors and it is the authors' hope that the findings will help identify exercise-related wellness interventions that could be implemented in veterinary medical schools. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 11, 2019

2017 journal article

A Novel Inflammation-Activated Drug Delivery System Using Self-Assembling Hydrogel Doubles Esophageal Dwell Time in an Esophageal Injury Porcine Model

Gastroenterology, 152(5), S859–S860.

By: E. Dellon, N. Joshi, A. Blikslager*, L. Gonzalez*, T. Pridgen, A. Whitlow, M. Ivanovic, K. Slaughter ...

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2017 journal article

Advanced three-dimensional culture of equine intestinal epithelial stem cells

Equine Veterinary Journal, 50(2), 241–248.

By: A. Stewart n, J. Freund n & L. Gonzalez n

author keywords: horse; stem cell; 3D culture; intestine; enteroid; organoid
MeSH headings : Animals; Cell Culture Techniques / veterinary; Cell Differentiation; Female; Horses; Intestinal Mucosa / cytology; Male; Models, Biological; Stem Cells / physiology
TL;DR: The successful culture of equine intestinal crypts into 3D "mini-guts" allows for in vitro studies of the equine intestine and has relevance to future development of novel therapies that harness the regenerative potential ofequine intestine in horses with gastrointestinal disease (colic). (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 review

Alterations in Intestinal Permeability: The Role of the "Leaky Gut" in Health and Disease

[Review of ]. JOURNAL OF EQUINE VETERINARY SCIENCE, 52, 10–22.

By: A. Stewart n, S. Pratt-Phillips n & L. Gonzalez n

author keywords: Horse; Intestinal permeability; Leaky gut; Barrier function; Decreased performance
TL;DR: The normal intestinal barrier, measurement of barrier permeability, pathogenesis and main causes of altered permeability are reviewed, and potential alternative therapies of leaky gut in horses are highlighted while relating what has been studied in other species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Ductular and proliferative response of esophageal submucosal glands in a porcine model of esophageal injury and repair

American Journal of Physiology-Gastrointestinal and Liver Physiology, 313(3), G180–G191.

By: L. Kruger n, L. Gonzalez n, T. Pridgen n, S. McCall*, R. Furstenberg*, I. Harnden*, G. Carnighan n, A. Cox n ...

author keywords: esophagus; injury; repair; esophageal submucosal gland; proliferation
MeSH headings : Active Transport, Cell Nucleus; Animals; Cell Proliferation / physiology; Esophageal Diseases / pathology; Esophagus / cytology; Esophagus / injuries; Female; Gene Expression Regulation / physiology; Humans; Male; SOX9 Transcription Factor / genetics; SOX9 Transcription Factor / metabolism; Staining and Labeling; Swine
TL;DR: A novel porcine model of injury and repair using radiofrequency ablation has been developed, allowing for reproducible injury to the esophagus to study repair in an animal model with esophageal submucosal glands, a key anatomical feature and missing in rodent models but possibly harboring progenitor cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Porcine Esophageal Submucosal Gland Culture Model Shows Capacity for Proliferation and Differentiation

Cellular and Molecular Gastroenterology and Hepatology, 4(3), 385–404.

By: R. von Furstenberg*, J. Li*, C. Stolarchuk*, R. Feder*, A. Campbell*, L. Kruger n, L. Gonzalez n, A. Blikslager n ...

author keywords: Esophagus; Barrett's Esophagus; 3D Culture; Acinar Ductal Metaplasia; Adult Stem Cell
TL;DR: The results suggest that the activated ESMG state, seen in both human disease and the authors' porcine model, may provide a source of cells to repopulate damaged epithelium in a normal manner (squamous) or abnormally (columnar epithelia). (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019

2017 journal article

Protein biomarker of cell proliferation determines survival to discharge in cases of equine large colon volvulus

Equine Veterinary Journal, 50(4), 452–456.

By: C. Kucera n, L. Stranahan n, F. Hughes*, A. Blikslager n & L. Gonzalez n

author keywords: horse; large colon volvulus; immunohistochemistry; phospho-histone H3; intestine; stem cell
MeSH headings : Animals; Biomarkers; Cell Proliferation / physiology; Cohort Studies; Colonic Diseases / veterinary; Female; Gene Expression Regulation; Horse Diseases / blood; Horses; Intestinal Volvulus / metabolism; Intestinal Volvulus / pathology; Intestinal Volvulus / veterinary; Male; ROC Curve; Retrospective Studies; Survival Analysis
TL;DR: PHH3 immunohistochemical analysis may assist in more accurate prediction of survival to hospital discharge of LCV cases and biomarkers PCNA, SOX9 and Ki-67 did not predict short-term survival. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Supplementation of Maternal Diets with Docosahexaenoic Acid and Methylating Vitamins Impacts Growth and Development of Fetuses from Malnourished Gilts

Current Developments in Nutrition, 2(3).

By: H. Lima n, X. Lin n, S. Jacobi n, C. Man n, J. Sommer n, W. Flowers n, A. Blikslager n, L. Gonzalez n, J. Odle n

Contributors: H. Lima n, X. Lin n, S. Jacobi n, C. Man n, J. Sommer n, W. Flowers n, A. Blikslager n, L. Gonzalez n, J. Odle n

author keywords: choline; B-vitamins; epigenetics; intrauterine growth restriction; nutrient restriction; low birth weight
TL;DR: Despite the mobilization of maternal stores, malnourished litters displayed reduced brain development that was fully mitigated by micronutrient supplementation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2016 journal article

27 AN IMPROVED LARGE ANIMAL MODEL FOR THE STUDY OF ADULT STEM CELLS

Reproduction, Fertility and Development, 28(2), 143.

By: S. Simpson n, L. Gonzalez n, J. Chung n, A. Blikslager n, S. Magness n & J. Piedrahita n

TL;DR: The generation of a porcine stem cell reporter line using the combination of transcription activator-like effector nucleases and somatic cell NT, which represents significant progress toward the study of adult stem cells, their progenitors, and the stem cell niche, using a large animal model with an anatomy, physiology, and ability to recapitulate human disease that overcomes the current limitations of rodent models. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2016 journal article

An Evaluation of the Psychometric Properties of an Advising Survey for Medical and Professional Program Students

Journal of Educational and Developmental Psychology, 6(1), 195.

By: K. Royal n & L. Gonzalez n

TL;DR: The psychometric properties of a newly developed instrument intended to measure faculty competence as it pertains to their role as advisors, particularly in medical and professional programs are evaluated. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 11, 2019

2016 chapter

Intestinal Stem Cells

In A. T. Blikslager, N. A. White, J. N. Moore, & T. S. Mair (Eds.), Equine Acute Abdomen (3rd ed.). Hoboken, NJ: Wiley & Sons, Inc.

By: L. Gonzalez

Ed(s): A. Blikslager, N. White, J. Moore & T. Mair

Source: NC State University Libraries
Added: September 11, 2019

2016 chapter

Intestinal Viability

In A. T. Blikslager, N. A. White, J. N. Moore, & T. S. Mair (Eds.), Equine Acute Abdomen (3rd ed., p. 570). Hoboken, NJ: Wiley & Sons, Inc.

By: L. Gonzalez

Ed(s): A. Blikslager, N. White, J. Moore & T. Mair

Source: NC State University Libraries
Added: September 11, 2019

2016 journal article

Large Animal Models: The Key to Translational Discovery in Digestive Disease Research

Cellular and Molecular Gastroenterology and Hepatology, 2(6), 716–724.

By: A. Ziegler n, L. Gonzalez n & A. Blikslager n

author keywords: Pig; Ischemia/Reperfusion Injury; Mucosal Repair; Tight Junction
TL;DR: Porcine model development has taken advantage of the size of the animal, allowing increased surgical and endoscopic access, and cellular tools are providing the methodology to translate basic science findings using in-depth mechanistic analyses, holding great promise for the future of clinically relevant digestive disease research. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: July 20, 2019

2016 journal article

Mo1253 Ductular and Proliferative Response of Esophageal Submucosal Glands in a Porcine Model of Esophageal Injury and Repair

Gastroenterology, 150(4), S679–S680.

By: L. Kruger, L. Gonzalez*, R. von Furstenberg, S. Henning, A. Blikslager* & K. Garman

Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2016 journal article

Mo1298 Critical Contribution of Intestinal Stem Cells in the Repair of Ischemia Reperfusion Injury

Gastroenterology, 150(4), S691.

By: A. Stewart, J. Freund, S. Magness, P. Lund, A. Blikslager* & L. Gonzalez*

Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2015 journal article

Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research

American Journal of Physiology-Gastrointestinal and Liver Physiology, 308(2), G63–G75.

By: L. Gonzalez n, A. Moeser n & A. Blikslager n

Contributors: L. Gonzalez n, A. Moeser n & A. Blikslager n

author keywords: animal model; intestine; ischemia; mucosal injury; reperfusion
MeSH headings : Animals; Disease Models, Animal; Humans; Intestines / injuries; Intestines / pathology; Ischemia / complications; Ischemia / pathology; Oxygen / metabolism; Reperfusion Injury / complications; Reperfusion Injury / metabolism; Reperfusion Injury / pathology; Translational Research, Biomedical / methods
TL;DR: This review assesses animal models of ischemia-reperfusion injury as well as the knowledge that has been derived from each to aid selection of appropriate research models. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2015 journal article

Characterization of discrete equine intestinal epithelial cell lineages

American Journal of Veterinary Research, 76(4), 358–366.

By: L. Gonzalez*, L. Kinnin & A. Blikslager*

Contributors: L. Gonzalez*, L. Kinnin & A. Blikslager*

MeSH headings : Animals; Cell Lineage; Colic / pathology; Colic / veterinary; Epithelial Cells / cytology; Female; Horse Diseases / pathology; Horses; Intestinal Mucosa / cytology
TL;DR: The methodology used can enhance detection of stem cells and progenitor cells as well as postmitotic cell lineages in equine intestinal tissues and may have relevance to regenerative potential of intestinal mucosa and survival in horses with colic. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2015 journal article

Porcine models of digestive disease: the future of large animal translational research

Translational Research, 166(1), 12–27.

By: L. Gonzalez n, A. Moeser n & A. Blikslager n

Contributors: L. Gonzalez n, A. Moeser n & A. Blikslager n

MeSH headings : Animals; Animals, Genetically Modified; Digestive System Diseases / etiology; Digestive System Diseases / physiopathology; Disease Models, Animal; Enterocolitis, Necrotizing / etiology; Gastrointestinal Tract / anatomy & histology; Gastrointestinal Tract / blood supply; Gastrointestinal Tract / injuries; Humans; Intestines / transplantation; Reperfusion Injury / etiology; Short Bowel Syndrome / etiology; Short Bowel Syndrome / therapy; Species Specificity; Stress, Psychological / complications; Swine; Translational Research, Biomedical; Wound Healing
TL;DR: This review assesses currently used porcine models of gastrointestinal physiology and disease and provides a rationale for the use of these models for future translational studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2015 article

The mother of a gut cell: Intestinal epithelial stem cells

Gonzalez, L. M. (2015, November). EQUINE VETERINARY EDUCATION, Vol. 27, pp. 559–560.

By: L. Gonzalez n

UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Mo1960 Intestinal Epithelial Cells Expressing Biomarkers of Crypt Base Columnar or Reserve Stem Cells Show Differential Resistance to Ischemia-Reperfusion Injury

Gastroenterology, 146(5), S-702.

By: L. Gonzalez*, S. Magness, P. Lund & A. Blikslager*

Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2014 journal article

Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013

Equine Veterinary Journal, 47(3), 279–284.

By: L. Gonzalez n, C. Fogle n, W. Baker, F. Hughes*, J. Law n, A. Motsinger-Reif n, A. Blikslager n

Contributors: L. Gonzalez n, C. Fogle n, W. Baker, F. Hughes*, J. Law n, A. Motsinger-Reif n, A. Blikslager n

author keywords: horse; large colon volvulus; strangulation; pelvic flexure; surgery
MeSH headings : Animals; Biopsy; Colon / pathology; Hemorrhage / pathology; Hemorrhage / veterinary; Horse Diseases / surgery; Horses; Intestinal Volvulus / pathology; Intestinal Volvulus / surgery; Intestinal Volvulus / veterinary; Logistic Models; Retrospective Studies
TL;DR: Histomorphometric measurements of interstitium-to-crypt ratio and degree of haemorrhage predict short-term outcome in cases of large colon volvulus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2013 journal article

Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration

PLoS One, 8(6).

By: L. Gonzalez, I. Williamson, J. Piedrahita, A. Blikslager & S. Magness

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Su1099 A Translational Porcine Model of Intestinal Stem Cells

Gastroenterology, 144(5), S-398.

By: L. Gonzalez*, A. Blikslager*, J. Piedrahita* & S. Magness

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2010 journal article

MRI FEATURES OF METACARPO(TARSO)PHALANGEAL REGION LAMENESS IN 40 HORSES

Veterinary Radiology & Ultrasound, 51(4), 404–414.

By: L. Gonzalez n, M. Schramme n, I. Robertson n, D. Thrall n & R. Redding n

author keywords: equine; fetlock; high-field magnetic resonance imaging; metacarpophalangeal joint; metatarsophalangeal joint
TL;DR: MRI provided information that was complementary to radiography, ultrasonography, and nuclear scintigraphy and that allowed for a comprehensive evaluation of all structures in the MP joint region and a diagnosis in all 40 horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

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