Leah M. Zadrozny

Works (5)

Updated: July 13th, 2023 21:17

2010 journal article

H-ras Consensus Sequence and Mutations in Primary Hepatocellular Carcinomas of Lemurs and Lorises

VETERINARY PATHOLOGY, 48(4), 868–874.

By: J. Cullen n, C. Williams*, L. Zadrozny n, J. Otstot*, G. Solomon*, R. Sills*, H. Hong*

author keywords: liver; molecular biology; oncology; primate; zoo; hepatocellular carcinoma
MeSH headings : Animals; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / pathology; Carcinoma, Hepatocellular / veterinary; Consensus Sequence; Female; Gene Expression Regulation, Neoplastic; Genes, ras / genetics; Lemur; Liver Neoplasms / genetics; Liver Neoplasms / pathology; Liver Neoplasms / veterinary; Lorisidae; Male; Mutation; Primate Diseases / genetics; Primate Diseases / pathology
TL;DR: The authors have determined a consensus sequence for exons 1 and 2 of H-ras from captive lemurs and lorises and evaluated samples of nonneoplastic liver and hepatocellular carcinomas from affected animals for mutations in these exons, and have determined that it is identical to that of human H-ra and differs only slightly from the chimpanzee sequence. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 journal article

Successful treatment of canine necrolytic migratory erythema (superficial necrolytic dermatitis) due to metastatic glucagonoma with octreotide

VETERINARY DERMATOLOGY, 21(5), 510–516.

By: U. Oberkirchner n, K. Linder n, L. Zadrozny n & T. Olivry n 

Contributors: U. Oberkirchner n, K. Linder n, L. Zadrozny n & T. Olivry n 

MeSH headings : Animals; Anorexia / chemically induced; Anorexia / veterinary; Antineoplastic Agents, Hormonal / administration & dosage; Antineoplastic Agents, Hormonal / adverse effects; Antineoplastic Agents, Hormonal / therapeutic use; Dog Diseases / drug therapy; Dogs; Dose-Response Relationship, Drug; Glucagonoma / complications; Glucagonoma / pathology; Glucagonoma / veterinary; Lymph Nodes / pathology; Male; Necrolytic Migratory Erythema / drug therapy; Necrolytic Migratory Erythema / veterinary; Octreotide / administration & dosage; Octreotide / adverse effects; Octreotide / therapeutic use; Pancreatic Neoplasms / complications; Pancreatic Neoplasms / veterinary; Paraneoplastic Syndromes / pathology; Paraneoplastic Syndromes / veterinary
TL;DR: Subcutaneous octreotide injections were beneficial in this dog with glucagonoma-associated NME and this somatostatin analogue could be a valuable option to treat canine patients with non-resectable or relapsing pancreatic glucagonomas- associated NME. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Spontaneous Hepatocellular Carcinoma in Captive Prosimians

VETERINARY PATHOLOGY, 47(2), 306–311.

By: L. Zadrozny n, C. Williams*, A. Remick & J. Cullen n

author keywords: Hepadnaviridae; hepatocellular carcinoma; iron; lemur; liver cell adenoma; neoplasms; prosimians
MeSH headings : Animals; Carcinoma, Hepatocellular / epidemiology; Carcinoma, Hepatocellular / pathology; Carcinoma, Hepatocellular / veterinary; Female; Histocytochemistry / veterinary; Incidence; Lemur; Liver Neoplasms / epidemiology; Liver Neoplasms / pathology; Liver Neoplasms / veterinary; Male; Monkey Diseases / epidemiology; Monkey Diseases / pathology; Retrospective Studies
TL;DR: Hepatocellular neoplasia is relatively common in captive prosimians, although previously suspected etiologies seem unlikely. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 journal article

5-Hydroxytryptamine (5HT)-induced valvulopathy: Compositional. valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 60(4-5), 253–262.

By: C. Elangbam*, L. Job n, L. Zadrozny n, J. Barton*, L. Yoon*, L. Gates*, N. Slocum*

author keywords: valvulopathy; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine transporter; anorexigens; compositional morphometry; quantitative image analysis; Sprague-Dawley rats
MeSH headings : Animals; Aortic Valve / chemistry; Aortic Valve / drug effects; Aortic Valve / pathology; Collagen / analysis; Gene Expression / drug effects; Glycosaminoglycans / analysis; Heart Valve Diseases / chemically induced; Heart Valve Diseases / pathology; Lasers; Microdissection; Mitral Valve / chemistry; Mitral Valve / drug effects; Mitral Valve / pathology; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B / biosynthesis; Receptor, Serotonin, 5-HT2B / drug effects; Serotonin / toxicity; Serotonin Agents / toxicity; Serotonin Plasma Membrane Transport Proteins / biosynthesis; Serotonin Plasma Membrane Transport Proteins / drug effects
TL;DR: Subcutaneous injections of 5HT for 7 days resulted in thickening and compositional alteration of aortic and mitral valves in SD rats, and valve-leaflets from 5HT-treated rats had greater valve thickness, a higher amount of glycosaminoglycans and a lower amount of collagen. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 journal article

Neutrophils do not mediate the pathophysiological sequelae of Cryptosporidium parvum infection in neonatal piglets

INFECTION AND IMMUNITY, 74(10), 5497–5505.

By: L. Zadrozny n, S. Stauffer*, M. Armstrong*, S. Jones n  & J. Gookin* 

MeSH headings : Animals; Antibodies / pharmacology; CD18 Antigens / drug effects; Cryptosporidiosis / immunology; Cryptosporidiosis / pathology; Cryptosporidium parvum; Diarrhea / immunology; Diarrhea / microbiology; Disease Models, Animal; Ileum / immunology; Ileum / microbiology; Ileum / pathology; Immunoglobulin G / pharmacology; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Lipid Peroxidation; Neutrophils / enzymology; Neutrophils / immunology; Peroxidase / analysis; Peroxidase / metabolism; Peroxynitrous Acid / metabolism; Prostaglandins / metabolism; Superoxides / metabolism; Swine
TL;DR: These studies are the first to demonstrate that neutrophilic inflammation arising in response to infection by a noninvasive epithelial pathogen results in physiologic rather than pathological effects in vivo. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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