Lewis Gaffney

Works (11)

Updated: April 24th, 2025 03:27

2023 journal article

Tendon Extracellular Matrix Promotes Myotendinous Junction Protein Expression in Engineered Muscle Tissue under Both Static and Mechanically Stimulated Culture Conditions

Journal of Tissue Engineering and Regenerative Medicine, 2023, 1–13.

By: L. Gaffney n, M. Fisher n  & D. Freytes n 

Ed(s): C. Kuo

MeSH headings : Animals; Tendons / metabolism; Tissue Engineering / methods; Extracellular Matrix / metabolism; Mice; Cell Line; Hydrogels / chemistry; Bioreactors; Myoblasts / cytology; Myoblasts / metabolism; Paxillin / metabolism; Myotendinous Junction
topics (OpenAlex): Tendon Structure and Treatment; Tissue Engineering and Regenerative Medicine; Knee injuries and reconstruction techniques
TL;DR: This research combined a relevant microenvironment to study muscle and tendon interactions with a novel bioreactor to apply mechanical strain, an important regulator of the formation and maintenance of the native MTJ. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: September 18, 2023

2022 journal article

Donor Age and Time in Culture Affect Dermal Fibroblast Contraction in an In Vitro Hydrogel Model

Tissue Engineering Part A, 28(19-20), 833–844.

By: A. Detwiler n, K. Polkoff n, L. Gaffney n, D. Freytes n  & J. Piedrahita n 

author keywords: cell proliferation; collagen; dermis; extracellular matrix; fibroblasts; hydrogels; skin; wound healing
MeSH headings : Adult; Infant, Newborn; Humans; Swine; Animals; Hydrogels / pharmacology; Reproducibility of Results; Wound Healing; Collagen / chemistry; Fibroblasts
topics (OpenAlex): Wound Healing and Treatments; Electrospun Nanofibers in Biomedical Applications; Tissue Engineering and Regenerative Medicine
TL;DR: Results show how cellular responses in a hydrogel scaffold differ based on donor age and time in culture in vitro, and suggest that consistency in the cellular component of bioengineered skin products could be beneficial in the biomanufacturing of consistent, reliable skin grafts and graft in vivo models. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 29, 2022

2021 journal article

Ex vivo evaluation of novel core tenorrhaphy patterns in dogs

Veterinary Surgery, 50(6), 1316–1325.

By: K. Chiu n, D. Duffy n, Y. Chang n, L. Gaffney n & M. Fisher n 

MeSH headings : Animals; Biomechanical Phenomena; Cadaver; Dog Diseases; Dogs; Random Allocation; Suture Techniques / veterinary; Sutures / veterinary; Tendon Injuries / surgery; Tendon Injuries / veterinary; Tensile Strength
topics (OpenAlex): Orthopedic Surgery and Rehabilitation; Tendon Structure and Treatment; Veterinary Orthopedics and Neurology
TL;DR: Use of novel patterns ExDCrL, EmDCrl, and MTang improved resistance to loads and gap formation and were biomechanically superior compared to 3LP in healthy canine tendon repairs in dogs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: July 12, 2021

2021 journal article

Extracellular Matrix Hydrogels Promote Expression of Muscle-Tendon Junction Proteins

Tissue Engineering Part A, 28(5-6), 270–282.

By: L. Gaffney n, Z. Davis n , C. Mora-Navarro n, M. Fisher n  & D. Freytes n 

author keywords: extracellular matrix; engineered tissues; myotendinous junction; paxillin
MeSH headings : Collagen / metabolism; Collagen Type I / metabolism; Culture Media, Conditioned; Extracellular Matrix / metabolism; Hydrogels; Muscles; Paxillin / metabolism; Tendons / metabolism
topics (OpenAlex): Tendon Structure and Treatment; Tissue Engineering and Regenerative Medicine; Sports injuries and prevention
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: November 15, 2021

2020 journal article

Biomechanical evaluation of an autologous flexor digitorum lateralis graft to augment the surgical repair of gastrocnemius tendon laceration in a canine ex vivo model

Veterinary Surgery, 49(8), 1545–1554.

By: D. Duffy n, C. Curcillo n, Y. Chang n, L. Gaffney n, M. Fisher n  & G. Moore *

MeSH headings : Animals; Autografts / physiology; Biomechanical Phenomena; Cadaver; Dogs / injuries; Dogs / surgery; Lacerations / surgery; Lacerations / veterinary; Muscle, Skeletal / surgery; Tendon Injuries / surgery; Tendon Injuries / veterinary; Tendons / transplantation; Transplantation, Autologous / veterinary
topics (OpenAlex): Tendon Structure and Treatment; Orthopedic Surgery and Rehabilitation; Shoulder Injury and Treatment
TL;DR: Use of FDL tendon augmentation for GT laceration may increase repair site strength and resist gap formation better than 3LP core suture use alone and increase yield, peak, and failure forces by twofold, 2.3-fold and 2.2-fold compared with core 3LP alone while preventing the occurrence of gap formation. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: November 24, 2020

2020 journal article

Influence of barbed epitendinous sutures combined with a core locking‐loop suture to repair experimental flexor tendon lacerations

Veterinary Surgery, 49(8), 1590–1599.

By: A. Eby n, D. Duffy n, Y. Chang n, L. Gaffney n, M. Fisher n  & G. Moore *

MeSH headings : Animals; Cadaver; Dogs / injuries; Dogs / surgery; Lacerations / surgery; Lacerations / veterinary; Plastic Surgery Procedures / veterinary; Suture Techniques / veterinary; Sutures / veterinary; Tendon Injuries / surgery; Tendon Injuries / veterinary; Tendons / surgery; Tensile Strength
topics (OpenAlex): Surgical Sutures and Adhesives; Orthopedic Surgery and Rehabilitation; Tendon Structure and Treatment
TL;DR: Investigating the influence of barbed epitendinous sutures on the biomechanical properties and gap formation of repaired canine tendons found Stratafix barbed suture performed better as an ES compared with other barbedSutures and similarly to monofilament suture. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: September 28, 2020

2020 journal article

Photoinduced reconfiguration to control the protein-binding affinity of azobenzene-cyclized peptides

Journal of Materials Chemistry B, 8(33), 7413–7427.

By: K. Day n, J. Schneible n, A. Young n, V. Pozdin n, G. Van Den Driessche  n, L. Gaffney n, R. Prodromou n, D. Freytes n  ...

Contributors: K. Day n, J. Schneible n, A. Young n, V. Pozdin n, G. Driessche  n, L. Gaffney n, R. Prodromou n, . al.

MeSH headings : Amino Acid Sequence; Azo Compounds / chemistry; Hydrogen-Ion Concentration; Isomerism; Osmolar Concentration; Peptides, Cyclic / chemistry; Photochemical Processes
topics (OpenAlex): Photochromic and Fluorescence Chemistry; Click Chemistry and Applications; Chemical Synthesis and Analysis
TL;DR: This study demonstrates a general method to develop azobenzene-cyclized peptide ligands with light-controlled affinity for target proteins by designing photo-switchable peptides targeting vascular cell adhesion marker 1 (VCAM1), a cell marker implicated in stem cell function. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: September 14, 2020

2019 journal article

Effect of bite depth of an epitendinous suture on the biomechanical strength of repaired canine flexor tendons

American Journal of Veterinary Research, 80(11), 1043–1049.

By: D. Duffy n, Y. Chang n, L. Gaffney n, M. Fisher n  & G. Moore *

MeSH headings : Animals; Biomechanical Phenomena; Cadaver; Dogs / surgery; Suture Techniques / veterinary; Tendon Injuries; Tendons / surgery; Tensile Strength
topics (OpenAlex): Orthopedic Surgery and Rehabilitation; Tendon Structure and Treatment; Surgical Sutures and Adhesives
TL;DR: Increasing bite depth of an epitendinous suture toward the center of the tendon substance increased repair site strength and decreased the incidence of gap formation. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: April 20, 2020

2018 journal article

Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes

Biomaterials Science, 7(2), 669–682.

By: S. Nandi n, E. Sproul n, K. Nellenbach n, M. Erb n, L. Gaffney n, D. Freytes n , A. Brown n 

MeSH headings : Animals; Biomimetic Materials / chemistry; Blood Platelets / metabolism; Blood Platelets / physiology; Fibrin / chemistry; Fibrin / pharmacology; Humans; Mechanical Phenomena; Mice; Platelet Activation / drug effects; Skin / drug effects; Skin / injuries; Wound Healing / drug effects
topics (OpenAlex): Blood properties and coagulation; Periodontal Regeneration and Treatments; Wound Healing and Treatments
TL;DR: The utility of PLPs for enhancing wound repair is demonstrated and the role of native platelet-mediated clot retraction in wound healing is provided, to provide insight into the role in vitro and in vivo models of wound healing. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: February 18, 2019

2017 journal article

Macrophages' role in tissue disease and regeneration

Macrophages: Origin, Functions and Biointervention, 62, 245–271.

By: L. Gaffney, P. Warren, E. Wrona, M. Fisher  & D. Freytes 

Source: NC State University Libraries
Added: August 6, 2018

2017 article

Potential Synergistic Effects of Stem Cells and Extracellular Matrix Scaffolds

Gaffney, L., Wrona, E. A., & Freytes, D. O. (2017, July 18). ACS Biomaterials Science & Engineering, Vol. 4, pp. 1208–1222.

By: L. Gaffney n, E. Wrona n & D. Freytes n 

Contributors: L. Gaffney n, E. Wrona n & D. Freytes n 

author keywords: extracellular matrix (ECM); stem cells; pluripotent stem cells (PSCs); wound healing; macrophage polarization
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; Graphene and Nanomaterials Applications
TL;DR: This work has shown that extracellular matrix-derived biomaterials, used as scaffolds to help regenerate diseased or damaged tissues, provide a scaffold material with native-like composition and structure through several mechanisms that include chemotactic properties, growth factor release, and modulation of the immune response. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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