Lauren V Schnabel

A NOVEL MATRIKINE STIMULATED EQUINE SYNOVIAL FIBROBLAST AND CHONDROCYTE COCULTURE MODEL OF OSTEOARTHRITIS: A PROPOSED ALTERNATIVE TO TRADITIONAL LPS AND IL-1B MODELS

Gagliardi, R., Loeser, R. F., & Schnabel, L. (2024, June). OSTEOARTHRITIS AND CARTILAGE, Vol. 32, pp. 780–781.

A novel matrikine stimulated equine synovial fibroblast and chondrocyte co-culture model of osteoarthritis: a proposed alternative to traditional LPS and Il-1b models

OARSI 2024 World Congress on Osteoarthritis. Presented at the OARSI 2024 World Congress on Osteoarthritis.

Animal drug shortages limit veterinary therapeutic options and introduce artifacts in antimicrobial sales reporting

Journal of the American Veterinary Medical Association, 262(4), 576–579.

Controlled Stiffness of Direct-Write, Near-Field Electrospun Gelatin Fibers Generates Differences in Tenocyte Morphology and Gene Expression

Journal of Biomechanical Engineering, 146(9).

Early degenerative changes are different between partial and complete anterior cruciate ligament injury and associate with joint instability in a skeletally immature porcine model

Osteoarthritis and Cartilage, 33(2), 302–312.

Editorial: Links between regenerative medicine and immunotherapy: how cellular therapies modulate immune responses for improved outcomes

Pezzanite, L., Barrachina, L., & Schnabel, L. (2024, July 26). FRONTIERS IN VETERINARY SCIENCE, Vol. 11.

Equity and Equine Medicine

North Carolina Veterinary Conference. Presented at the North Carolina Veterinary Conference, Raleigh, NC.

Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity

Bioorganic & Medicinal Chemistry Letters, 99, 129609.

Fighting fibrin with fibrin: Vancomycin delivery into coagulase‐mediated <i>Staphylococcus aureus</i> biofilms via fibrin‐based nanoparticle binding

Journal of Biomedical Materials Research Part A, 112(12), 2071–2085.

IL-1β + TGF-β2 dual-licensed mesenchymal stem cells have reduced major histocompatibility class I expression and positively modulate tenocyte migration, metabolism, and gene expression

Journal of the American Veterinary Medical Association, 262(S1), S61–S72.

Initial Investigation into the Effects of Tissue Plasminogen Activator on Intrasynovial Tenocytes In Vitro

Presented at the 2024 American College of Veterinary Sports Medicine and Rehabilitation Symposium Scientific/Clinical Abstract Sessions.

Matrikine stimulation of equine synovial fibroblasts and chondrocytes results in an in vitro osteoarthritis phenotype

Journal of Orthopaedic Research, 43(2), 292–303.

Mitigating the Risk of Corticosteroid-Induced Laminitis

Association of Equine Practitioners (AAEP) Convention and Trade Show. Presented at the Association of Equine Practitioners (AAEP) Convention and Trade Show, Orlando, FL.

No correlation found between palpation and ultrasound for evaluation of effusion in the medial femorotibial and femoropatellar joint compartments of horses

Journal of the American Veterinary Medical Association, 262(4), 476–480.

Palpation and Ultrasound Assessment of Naturally Occurring Effusion of the Equine Stifle

Presented at the 2024 American College of Veterinary Sports Medicine and Rehabilitation Symposium Scientific/Clinical Abstract Sessions.

Pyrrolidine-2,3-diones: heterocyclic scaffolds that inhibit and eradicate <i>S. aureus</i> biofilms

Chemical Communications, 60(81), 11540–11543.

Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs

Frontiers in Pharmacology, 15.

Systemic Absorption of Triamcinolone Acetonide Following Intrasynovial and Extrasynovial Articular Injection

AAEP Convention. Presented at the AAEP Convention.

Systemic absorption of triamcinolone acetonide is increased from intrasynovial versus extrasynovial sites and induces hyperglycemia, hyperinsulinemia, and suppression of the hypothalamic-pituitary-adrenal axis

Frontiers in Veterinary Science, 11.

Temperature has a greater effect than salinity on microbial survival in saltwater from a single equine hydrotherapy unit

American Journal of Veterinary Research, 85(11).

Ultrasoft platelet-like particles stop bleeding in rodent and porcine models of trauma

Science Translational Medicine, 16(742).

Understanding the Potent Antibiofilm Activity of Natural Product-derived Lipoxazolidinones

North Carolina Branch ASM Annual Meeting and Research Symposium. Presented at the North Carolina Branch ASM Annual Meeting and Research Symposium, Wilmington, NC.

A Novel Equine In Vitro Model of Osteoarthritis Utilizing Fibronectin Fragment (FN7-10) Stimulated Synovial Fibroblasts and Chondrocytes

ACVS Surgery Summit 2023. Poster presented at the ACVS Surgery Summit 2023.

Advances in the diagnosis of tendon and ligament injuries

Florida Association of Equine Practitioners (FAEP) Promoting Excellence Symposium. Presented at the Florida Association of Equine Practitioners (FAEP) Promoting Excellence Symposium, West Palm Beach, FL.

Antimicrobial Properties of Equine Stromal Cells and Platelets and Future Directions

Veterinary Clinics of North America: Equine Practice, 39(3), 565–578.

Back Pain in the Horse: Diagnosis and Management

North Carolina Veterinary Conference. Presented at the North Carolina Veterinary Conference, Raleigh, NC.

Biofilm formation in septic synovitis and novel therapies

American College of Veterinary Surgeons Surgery Summit. Presented at the American College of Veterinary Surgeons Surgery Summit, Louisville, KY.

Common causes of fetlock pain, management, and prognosis

The Equine Practice Company Lameness Program. Presented at the The Equine Practice Company Lameness Program.

Considerations for the Use of Biologic and Regenerative Therapies in Equine Practice

Veterinary Clinics of North America: Equine Practice, 39(3), xiii-xiv.

Degenerative Changes Are Associated with Joint Stability after Partial and Complete ACL Injury in a Skeletally Immature Porcine Model

`ORS (Orthopaedic Research Society) Annual Meeting 2023. Presented at the ORS (Orthopaedic Research Society) Annual Meeting 2023.

Effect of gentamicin on <scp>CD3</scp>+ T‐lymphocyte proliferation for treatment of equine recurrent uveitis: An in vitro study

Veterinary Ophthalmology, 26(4), 347–354.

Enhanced Clotting in Synovial Fluid with Colloidal-Composite Gels for Partial Anterior Cruciate Ligament Tears

ORS (Orthopaedic Research Society) Annual Meeting 2023. Poster presented at the ORS (Orthopaedic Research Society) Annual Meeting 2023.

Evaluating the safety and efficacy of allogeneic stem cell products: what do you need to know?

Locomotion in Practice 2023. Presented at the Locomotion in Practice 2023, Netherlands.

IL-1b and TGF-b2 dual licensed mesenchymal stem cells downregulate MHC I expression and enhance tendon fibroblast migration in vitro

ACVS Surgery Summit 2023. Poster presented at the ACVS Surgery Summit 2023.

Mesenchymal stem cell licensing: enhancing MSC function as a translational approach for the treatment of tendon injury

American Journal of Veterinary Research, 84(10), 1–8.

Neo-natal castration leads to subtle differences in porcine anterior cruciate ligament morphology and function in adolescence

Thompson, J. D., Howe, D., Griffith, E. H., Schnabel, L. V., & Fisher, M. B. (2023, January 25).

New Horizons in Viscosupplementation and Rehabilitation for the Treatment of Joint Disease

American Association of Equine Veterinary Technicians and Assistants Convention. Presented at the American Association of Equine Veterinary Technicians and Assistants Convention, San Diego, CA.

Orthobiologics for soft tissue injuries

American College of Veterinary Sports Medicine and Rehabilitation Symposium. Presented at the American College of Veterinary Sports Medicine and Rehabilitation Symposium, Charleston, SC.

Pneumatic Compression Therapy Using the EQ Press Accelerates Lymphatic Flow in Healthy Equine Forelimbs as Determined by Lymphoscintigraphy

Presented at the 2023 American College of Veterinary Sports Medicine and Rehabilitation Symposium Scientific/Clinical Abstract Sessions.

Pneumatic compression therapy using the EQ Press accelerates lymphatic flow in healthy equine forelimbs as determined by lymphoscintigraphy

American Journal of Veterinary Research, 84(4), 1–6.

Point-of-care biologics and viscoelastic therapies for the treatment of musculoskeletal injuries

Florida Association of Equine Practitioners (FAEP) Promoting Excellence Symposium. Presented at the Florida Association of Equine Practitioners (FAEP) Promoting Excellence Symposium, West Palm Beach, FL.

Preclinical tendon and ligament models: Beyond the 3Rs (replacement, reduction, and refinement) to 5W1H (why, who, what, where, when, how)

Journal of Orthopaedic Research, 41(10), 2133–2162.

Rehabilitation and monitoring of tendon and ligament injuries

Florida Association of Equine Practitioners Promoting Excellence Symposium (FAEP). Presented at the Florida Association of Equine Practitioners Promoting Excellence Symposium (FAEP), West Palm Beach, FL.

Systemic Absorption of Triamcinolone Acetonide following Intrasynovial and Extrasynovial Articular Injection

Presented at the 2023 American College of Veterinary Sports Medicine and Rehabilitation Symposium Scientific/Clinical Abstract Sessions.

TGF-β downregulates antigen processing and presentation genes and MHC I surface expression through a Smad3-dependent mechanism

Berglund, A. K., Hinson, A. L., & Schnabel, L. V. (2023, February 1).

Use of mesenchymal stem cells for tendon healing in veterinary and human medicine: getting to the “core” of the problem through a one health approach

Journal of the American Veterinary Medical Association, 261(10), 1435–1442.

Use of stem cells for the treatment of musculoskeletal injuries: what type, how, and when?

Florida Association of Equine Practitioners (FAEP) Promoting Excellence Symposium. Presented at the Florida Association of Equine Practitioners (FAEP) Promoting Excellence Symposium, West Palm Beach, FL.

Variable stiffness Crosslinking method of aligned direct-write, near-field electrospun gelatin fibers alter stiffness, cytocompatibility, and increased cellular aspect ratios of tenocytes

ORS (Orthopaedic Research Society) Annual Meeting 2023. Poster presented at the ORS (Orthopaedic Research Society) Annual Meeting 2023.

Viscoelastic therapies for osteoarthritis management

American College of Veterinary Sports Medicine and Rehabilitation Symposium. Presented at the American College of Veterinary Sports Medicine and Rehabilitation Symposium, Charleston, SC.

A Platelet-Rich Plasma-Derived Biologic Clears Staphylococcus aureus Biofilms While Mitigating Cartilage Degeneration and Joint Inflammation in a Clinically Relevant Large Animal Infectious Arthritis Model

Frontiers in Cellular and Infection Microbiology, 12.

A call to action for veterinarians and partners in animal health to collect antimicrobial use data for the purposes of supporting medical decision-making and antimicrobial stewardship

Journal of the American Veterinary Medical Association, 260(8), 853–859.

Alterations to the synovial invaginations of the navicular bone are associated with pathology of both the navicular apparatus and distal interphalangeal joint when evaluated using high field MRI

Veterinary Radiology & Ultrasound, 64(1), 9–17.

Defining the profile: Characterizing cytokines in tendon injury to improve clinical therapy

Journal of Immunology and Regenerative Medicine, 16, 100059.

Interleukin-1β in tendon injury enhances reparative gene and protein expression in mesenchymal stem cells

Frontiers in Veterinary Science, 9.

Leveraging MRI characterization of longitudinal tears of the deep digital flexor tendon in horses using machine learning

ELKhamary, A. N., Keenihan, E. K., Schnabel, L. V., Redding, W. R., & Schumacher, J. (2022, April 12). VETERINARY RADIOLOGY & ULTRASOUND, Vol. 4.

Non-steroidal anti-inflammatory drugs in equine orthopaedics

Jacobs, C. C., Schnabel, L. V., McIlwraith, C. W., & Blikslager, A. T. (2022, February 10). EQUINE VETERINARY JOURNAL, Vol. 2.

Potent Activity of Ertapenem Plus Cefazolin Within Staphylococcal Biofilms: A Contributing Factor in the Treatment of Methicillin-Susceptible <i>Staphylococcus aureus</i> Endocarditis

Open Forum Infectious Diseases, 9(5).

TGF-β2 enhances expression of equine bone marrow-derived mesenchymal stem cell paracrine factors with known associations to tendon healing

Stem Cell Research & Therapy, 13(1).

TLR-activated mesenchymal stromal cell therapy and antibiotics to treat multi-drug resistant Staphylococcal septic arthritis in an equine model

Annals of Translational Medicine, 10(21), 1157–1157.

Tendon sheath masses - What are the differential diagnoses and what diagnostics are needed?

Schnabel, L. V., Horne, C. R., & Jacobs, C. C. (2022, June 13). EQUINE VETERINARY EDUCATION, Vol. 6.

Adeno-Associated Virus-Mediated Overexpression of Interleukin-10 Affects the Immunomodulatory Properties of Equine Bone Marrow-Derived Mesenchymal Stem Cells

HUMAN GENE THERAPY, 32(17-18), 907–918.

Effects of continuous passage on the immunomodulator properties of equine bone marrow-derived mesenchymal stem cells in vitro (vol 234, 110203, 2021)

Connard, S. S., Linardi, R. L., Even, K. M., Berglund, A. K., Schnabel, L. V., & Ortved, K. F. (2021, December). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 242.

Effects of continuous passage on the immunomodulatory properties of equine bone marrow-derived mesenchymal stem cells in vitro

Veterinary Immunology and Immunopathology, 234, 110203.

Pathology in Practice

Journal of the American Veterinary Medical Association, 258(9), 961–964.

TGF-β2 Reduces the Cell-Mediated Immunogenicity of Equine MHC-Mismatched Bone Marrow-Derived Mesenchymal Stem Cells Without Altering Immunomodulatory Properties

Frontiers in Cell and Developmental Biology, 9.

Cross-matching of allogeneic mesenchymal stromal cells eliminates recipient immune targeting

STEM CELLS TRANSLATIONAL MEDICINE, 10(5), 694–710.

Front Cover: 5‐Benzylidene‐4‐Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms (ChemBioChem 7/2020)

ChemBioChem, 21(7), 883–883.

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

NATURE COMMUNICATIONS, 11(1).

One Health in Regenerative Medicine: Report on the Second Havemeyer Symposium on Regenerative Medicine in Horses

Regenerative Medicine, 15(6), 1775–1787.

Platelet-rich plasma lysate displays antibiofilm properties and restores antimicrobial activity against synovial fluid biofilms in vitro

JOURNAL OF ORTHOPAEDIC RESEARCH, 38(6), 1365–1374.

The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence

OSTEOARTHRITIS AND CARTILAGE, 29(3), 402–412.

5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms

CHEMBIOCHEM, Vol. 21, pp. 933–937.

Effects of acellular equine amniotic allografts on the healing of experimentally induced full-thickness distal limb wounds in horses

VETERINARY SURGERY, 48(8), 1416–1428.

Equine or porcine synovial fluid as a novel ex vivo model for the study of bacterial free-floating biofilms that form in human joint infections

PLOS ONE, 14(8), e0221012.

Ultrasound-Guided Proximolateral Approach for Digital Flexor Tendon Sheath Injection in the Horse: A Cadaver Study

VCOT Open, 02(02), e37–e43.

Gram-negative multi-drug resistant bacteria influence survival to discharge for horses with septic synovial structures: 206 Cases (2010-2015)

VETERINARY MICROBIOLOGY, 226, 64–73.

Inflammatory licensed equine MSCs are chondroprotective and exhibit enhanced immunomodulation in an inflammatory environment

STEM CELL RESEARCH & THERAPY, 9.

Oral reserpine administration in horses results in low plasma concentrations that alter platelet biology

EQUINE VETERINARY JOURNAL, 51(4), 537–543.

Pooled Platelet-Rich Plasma Lysate Therapy Increases Synoviocyte Proliferation and Hyaluronic Acid Production While Protecting Chondrocytes From Synoviocyte-Derived Inflammatory Mediators

FRONTIERS IN VETERINARY SCIENCE, 5.

Effect of bone marrow-derived mesenchymal stem cells and stem cell supernatant on equine corneal wound healing in vitro

Stem Cell Research & Therapy, 8(1).

The immunomodulatory function of equine MSCs is enhanced by priming through an inflammatory microenvironment or TLR3 ligand

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 195, 33–39.

Allogeneic major histocompatibility complex-mismatched equine bone marrow-derived mesenchymal stem cells are targeted for death by cytotoxic anti-major histocompatibility complex antibodies

EQUINE VETERINARY JOURNAL, 49(4), 539–544.

Diagnosis and management of proximal sesamoid bone fractures in the horse

[Review of ]. EQUINE VETERINARY EDUCATION, 30(8), 450–455.

Equine allogeneic bone marrow-derived mesenchymal stromal cells elicit antibody responses in vivo

STEM CELL RESEARCH & THERAPY, 6.

Mesenchymal Stem Cell Therapy: Clinical Progress and Opportunities for Advancement

Current Pathobiology Reports, 3(1), 1–7.

Equine bone marrow-derived mesenchymal stromal cells are heterogeneous in MHC class II expression and capable of inciting an immune response in vitro

STEM CELL RESEARCH & THERAPY, 5.

Induced pluripotent stem cells have similar immunogenic and more potent immunomodulatory properties compared with bone marrow-derived stromal cells in vitro

REGENERATIVE MEDICINE, 9(5), 621–635.

Navigational ultrasound imaging: A novel imaging tool for aiding interventional therapies of equine musculoskeletal injuries

EQUINE VETERINARY JOURNAL, 48(2), 195–200.

Equine bone marrow-derived mesenchymal stem cells are heterogeneous in MHC Class II expression and capable of inciting an immune response in vitro

NCSU/UNC Regenerative Medicine Symposium. Presented at the NCSU/UNC Regenerative Medicine Symposium.

Therapeutic use of stem cells in horses: Which type, how, and when?

The Veterinary Journal, 197(3), 570–577.

Cell- and gene-based approaches to tendon regeneration

Journal of Shoulder and Elbow Surgery, 21(2), 278–294.

Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons

Journal of Orthopaedic Research, 27(10), 1392–1398.

Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons

Journal of Orthopaedic Research, 25(2), 230–240.