Lauren V Schnabel

Works (45)

Updated: April 22nd, 2024 07:45

2024 journal article

Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs

FRONTIERS IN PHARMACOLOGY, 15.

By: A. Moatti n , S. Connard n, N. De Britto n, W. Dunn*, S. Rastogi n, M. Rai n, L. Schnabel n, F. Ligler* ...

author keywords: intratympanic; inner ear; fluid simulation; round window membrane; pigs; swine; pharmacokinetics
TL;DR: The potential of using pigs as a large animal model for studying inner ear pharmacokinetic studies of the inner ear using pigs is demonstrated and the diffusion time and drug concentrations reported align closely with the limited data available from human studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: February 19, 2024

2023 journal article

Antimicrobial Properties of Equine Stromal Cells and Platelets and Future Directions

VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE, 39(3), 565–578.

By: L. Pezzanite *, L. Chow *, S. Dow *, L. Goodrich *, J. Gilbertie* & L. Schnabel n

author keywords: Horse; Antimicrobial; Regenerative; Biologic; Therapies; Mesenchymal stromal cells; Platelets
TL;DR: Mechanisms by which biological therapies exert antimicrobial effects are discussed, as well as potential applications and challenges in clinical implementation in equine practice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: November 27, 2023

2023 article

Considerations for the Use of Biologic and Regenerative Therapies in Equine Practice

Schnabel, L. V. (2023, December). VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE, Vol. 39, pp. XIII-XIV.

By: L. Schnabel n

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: November 27, 2023

2023 journal article

Effect of gentamicin on <scp>CD3</scp>+ T‐lymphocyte proliferation for treatment of equine recurrent uveitis: An in vitro study

Veterinary Ophthalmology, 26(4), 347–354.

By: H. Smith  n, A. Berglund n, J. Robertson n , L. Schnabel n, R. McMullen *, B. Gilger n , A. Oh n 

author keywords: autoimmune disease; equine recurrent uveitis; gentamicin; horse; immunology; intravitreal injection
TL;DR: Gentamicin had no effect on equine peripheral blood CD3+ T-lymphocyte cell viability and proliferation in concentrations ranging from "safe" to "retinotoxic" in relation to intravitreal injection volumes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: April 29, 2023

2023 journal article

Pneumatic compression therapy using the EQ Press accelerates lymphatic flow in healthy equine forelimbs as determined by lymphoscintigraphy

AMERICAN JOURNAL OF VETERINARY RESEARCH, 84(4).

By: D. Koch n, L. Schnabel n, J. Reynolds n & C. Berry n

MeSH headings : Horses; Animals; Lymphoscintigraphy / veterinary; Technetium Tc 99m Sulfur Colloid; Lymph Nodes; Lymphedema / diagnostic imaging; Lymphedema / therapy; Lymphedema / veterinary; Forelimb / diagnostic imaging; Radiopharmaceuticals; Horse Diseases / pathology
TL;DR: Pneumatic compression therapy as provided by an equine-specific device encouraged lymphatic flow in healthy, nonedematous equine forelimbs and data support further study of the EQ Press for pneumatic compressor therapy in horses clinically affected by lymphedema and lymphatic drainage disorders. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: May 22, 2023

2023 journal article

Use of mesenchymal stem cells for tendon healing in veterinary and human medicine: getting to the "core" of the problem through a one health approach

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 261(10), 1435–1442.

By: L. V. Schnabel  n & D. Koch n

author keywords: mesenchymal stem cell; Achilles tendon; superficial digital flexor tendon; core lesion; one health
TL;DR: Why the equine superficial digital flexor tendon core lesion might be considered optimal for stem cell delivery and stem cell interaction with the injury environment is reviewed and the concept of stem cell licensing for future evaluation is introduced. (via Semantic Scholar)
Source: Web Of Science
Added: March 4, 2024

2022 journal article

A Platelet-Rich Plasma-Derived Biologic Clears Staphylococcus aureus Biofilms While Mitigating Cartilage Degeneration and Joint Inflammation in a Clinically Relevant Large Animal Infectious Arthritis Model

Frontiers in Cellular and Infection Microbiology, 12.

By: J. Gilbertie n, T. Schaer*, J. Engiles *, G. Seiler n, B. Deddens n, A. Schubert n, M. Jacob n, D. Stefanovski * ...

author keywords: infectious arthritis; S; aureus; biofilm; antimicrobial; platelets; cartilage; synovium; synovial fluid
MeSH headings : Amikacin; Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Arthritis, Infectious / drug therapy; Biofilms; Biological Products; Disease Models, Animal; Horses; Inflammation; Platelet-Rich Plasma; Staphylococcal Infections / drug therapy; Staphylococcal Infections / veterinary; Staphylococcus aureus
TL;DR: The results demonstrate the in vivo efficacy of AMK+BIO-PLY and represents a new approach to restore and potentiate antimicrobial activity against synovial fluid biofilms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: June 20, 2022

2022 article

Alterations to the synovial invaginations of the navicular bone are associated with pathology of both the navicular apparatus and distal interphalangeal joint when evaluated using high field MRI

McParland, T. J., Horne, C. R., Robertson, J. B., Schnabel, L. V., & Nelson, N. C. (2022, August 15). VETERINARY RADIOLOGY & ULTRASOUND, Vol. 8.

By: T. McParland n, C. Horne n, J. Robertson n , L. Schnabel n & N. Nelson n

author keywords: distal sesamoid bone; foot; horse; imaging
MeSH headings : Animals; Horses; Retrospective Studies; Joints; Tarsal Bones / diagnostic imaging; Magnetic Resonance Imaging / veterinary; Foot; Horse Diseases
TL;DR: Findings suggest that primary DIPJ disease and NA pathology should be considered when noticing alterations to navicular synovial invaginations on MRI, which contrasts traditional views that synovials invagination abnormalities are indicative solely of NA pathology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 22, 2022

2022 journal article

Interleukin-1 beta in tendon injury enhances reparative gene and protein expression in mesenchymal stem cells

FRONTIERS IN VETERINARY SCIENCE, 9.

By: D. Koch n, A. Berglund n, K. Messenger n, J. Gilbertie n, I. Ellis n & L. Schnabel n

author keywords: tendon; cytokine; ultrafiltration probe; mesenchymal stem cell; licensing
TL;DR: The defined temporal cytokine microenvironment in a surgically induced model of equine tendon injury and changes in MSC gene and protein expression following in vitro inflammatory licensing with cytokines of similar concentration as identified in vivo support the need to further study the benefit of MSCs administered within the inflamed tendon microenvironment or exogenously licensed with IL-1β in vitro prior to treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: December 12, 2022

2022 article

Leveraging MRI characterization of longitudinal tears of the deep digital flexor tendon in horses using machine learning

ELKhamary, A. N., Keenihan, E. K., Schnabel, L. V., Redding, W. R., & Schumacher, J. (2022, April 12). VETERINARY RADIOLOGY & ULTRASOUND.

By: A. ELKhamary*, E. Keenihan n, L. Schnabel n, W. Redding n & J. Schumacher*

author keywords: equine; feature extraction; longitudinal tear grading; machine learning classifier; tenoscopy
MeSH headings : Animals; Horse Diseases / diagnosis; Horses; Machine Learning; Magnetic Resonance Imaging / veterinary; Retrospective Studies; Tendons / diagnostic imaging
TL;DR: A systematic approach combining quantitative features with qualitative analyses using ML was diagnostically beneficial in MRI characterization and in discriminating between different grades of LTs of the DDFT of horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: Web Of Science
Added: April 25, 2022

2022 article

Non-steroidal anti-inflammatory drugs in equine orthopaedics

Jacobs, C. C., Schnabel, L. V., McIlwraith, C. W., & Blikslager, A. T. (2022, February 10). EQUINE VETERINARY JOURNAL, Vol. 2.

By: C. Jacobs n, L. Schnabel n, C. McIlwraith * & A. Blikslager n 

author keywords: horse; non-steroidal anti-inflammatory drug; orthopaedics; osteoarthritis
TL;DR: This review aims to summarise the current literature on the use of NSAIDs for equine orthopaedic disorders and examines new and future avenues for the management of inflammation in equine Orthopaedics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: February 28, 2022

2022 journal article

Potent Activity of Ertapenem Plus Cefazolin Within Staphylococcal Biofilms: A Contributing Factor in the Treatment of Methicillin-Susceptible Staphylococcus aureus Endocarditis

OPEN FORUM INFECTIOUS DISEASES, 9(5).

By: J. Gilbertie n, E. Ulloa *, J. Daiker n, K. Nguyen *, D. Smelter *, W. Rose *, M. Geriak*, L. Schnabel n, V. Nizet *, G. Sakoulas *

author keywords: cefazolin; ertapenem; endocarditis; Staphylococcus aureus
TL;DR: Ertapenem reduces CZ concentrations required to eradicate MSSA biofilms to those achievable in vivo by standard dosing, translating into shorter bacteremia duration in patients with MSSA endocarditis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: May 10, 2022

2022 journal article

TGF-beta 2 enhances expression of equine bone marrow-derived mesenchymal stem cell paracrine factors with known associations to tendon healing

STEM CELL RESEARCH & THERAPY, 13(1).

By: D. Koch n, L. Schnabel n, I. Ellis n, R. Bates n & A. Berglund n

author keywords: Mesenchymal stem cell; Tenocyte; TGF-beta 2; Equine; Tendon; RNA-sequencing; Paracrine factors; Extracellular matrix
MeSH headings : Animals; Bone Marrow / metabolism; Collagen Type I / metabolism; Cytokines / metabolism; Horses; Mesenchymal Stem Cells / metabolism; Paracrine Communication; RNA / metabolism; Tenascin / genetics; Tenascin / metabolism; Tendons / metabolism; Transforming Growth Factor beta2 / genetics; Transforming Growth Factors / metabolism
TL;DR: Treating equine BM-MSCs with TGF-β2 significantly increases production of paracrine factors and extracellular matrix molecules important for tendon healing and promotes the migration of tenocytes in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 26, 2022

2022 article

TLR-activated mesenchymal stromal cell therapy and antibiotics to treat multi-drug resistant Staphylococcal septic arthritis in an equine model

Pezzanite, L. M., Chow, L., Phillips, J., Griffenhagen, G. M., Moore, A. R., Schaer, T. P., … Goodrich, L. R. (2022, September 23). ANNALS OF TRANSLATIONAL MEDICINE.

By: L. Pezzanite *, L. Chow *, J. Phillips*, G. Griffenhagen *, A. Moore*, T. Schaer*, J. Engiles *, N. Werpy* ...

author keywords: Antibiotic resistance; infectious arthritis; mesenchymal stromal cell (MSC)
TL;DR: Combined TLR-activated MSC with antibiotic therapy may be a promising approach to manage joint infections with drug resistant bacteria. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 28, 2022

2022 article

Tendon sheath masses - What are the differential diagnoses and what diagnostics are needed?

Schnabel, L. V., Horne, C. R., & Jacobs, C. C. (2022, June 13). EQUINE VETERINARY EDUCATION.

By: L. Schnabel n, C. Horne n & C. Jacobs n

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 27, 2022

2021 journal article

Adeno-Associated Virus-Mediated Overexpression of Interleukin-10 Affects the Immunomodulatory Properties of Equine Bone Marrow-Derived Mesenchymal Stem Cells

HUMAN GENE THERAPY, 32(17-18), 907–918.

By: A. Cameron*, K. Even*, R. Linardi*, A. Berglund n, L. Schnabel n, J. Engiles *, K. Ortved *

author keywords: osteoarthritis; PTOA; immunomodulation; mesenchymal stem cell; IL-10; AAV
MeSH headings : Animals; Bone Marrow; Cells, Cultured; Dependovirus / genetics; Horses; Interleukin-10 / genetics; Mesenchymal Stem Cells
TL;DR: It is hypothesized that BM-MSCs overexpressing IL-10 would have superior immunomodulatory effects leading to increased suppression of T-cell proliferation and decreased production of pro-inflammatory cytokines providing protection of the extra-cellular matrix (ECM) in a stimulated, co-culture OA model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: May 24, 2021

2021 journal article

Cross-matching of allogeneic mesenchymal stromal cells eliminates recipient immune targeting

STEM CELLS TRANSLATIONAL MEDICINE, 10(5), 694–710.

By: A. Rowland*, D. Miller *, A. Berglund n, L. Schnabel n, G. Levine*, D. Antczak*, A. Watts*

author keywords: allogeneic; alloimmunization; antibody; autologous; cross&#8208; match; humoral; innate; intra&#8208; articular; major histocompatibility complex (MHC); MSC
MeSH headings : Adaptive Immunity; Allografts; Animals; Chemokine CXCL12; Histocompatibility Testing / veterinary; Horses; Immunity, Innate; Major Histocompatibility Complex; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Synovial Fluid / immunology; Transplantation, Autologous
TL;DR: Until immune recognition of MSCs can be avoided, repeated clinical use of M SCs should be limited to autologous or cross‐matched allogeneic MSC s, and presensitization against donor MHC should be assessed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 11, 2021

2021 article

Effects of continuous passage on the immunomodulator properties of equine bone marrow-derived mesenchymal stem cells in vitro (vol 234, 110203, 2021)

Connard, S. S., Linardi, R. L., Even, K. M., Berglund, A. K., Schnabel, L. V., & Ortved, K. F. (2021, December). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 242.

By: S. Connard *, R. Linardi*, K. Even*, A. Berglund n, L. Schnabel n & K. Ortved *

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 7, 2022

2021 journal article

Effects of continuous passage on the immunomodulatory properties of equine bone marrow-derived mesenchymal stem cells in vitro

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 234.

By: S. Connard *, R. Linardi*, K. Even*, A. Berglund n, L. Schnabel n & K. Ortved *

author keywords: Horse; Mesenchymal stem cells; Continuous passage; Immunomodulation
MeSH headings : Animals; Bone Marrow Cells / drug effects; Bone Marrow Cells / immunology; Bone Marrow Cells / physiology; Cell Differentiation / drug effects; Cell Differentiation / immunology; Cell Proliferation / drug effects; Cells, Cultured; Cytokines / analysis; Cytokines / biosynthesis; Cytokines / immunology; Female; Horses; Immunomodulation; In Vitro Techniques; Interferon-gamma / pharmacology; Lymphocyte Activation / drug effects; Lymphocyte Activation / immunology; Male; Mesenchymal Stem Cells / immunology; Mesenchymal Stem Cells / physiology
TL;DR: It is demonstrated that culture expansion affects some of the immunomodulatory properties of BM-MSCs in vitro, which may suggest that MSCs isolated from a single collection of bone marrow may be culture expanded, but only those from lower passage numbers would be ideal for clinical application. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 12, 2021

2021 journal article

Pathology in Practice

Journal of the American Veterinary Medical Association, 258(9), 961–964.

By: A. DiDomenico n, A. Fowler n, C. Horne n, P. Bizikova n, L. Schnabel n & D. Stowe n 

MeSH headings : Animals
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: June 10, 2021

2021 journal article

TGF-beta 2 Reduces the Cell-Mediated Immunogenicity of Equine MHC-Mismatched Bone Marrow-Derived Mesenchymal Stem Cells Without Altering Immunomodulatory Properties

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 9.

By: A. Berglund n, J. Long n, J. Robertson n  & L. Schnabel n

author keywords: mesenchymal stem cell; TGF-&#946; 2; cytotoxicity; immunogenicity; major histocompatibility complex; allogeneic
TL;DR: It is indicated that treating MSCs with TGF-β2 is a promising strategy to reduce the cell-mediated immunogenicity of MHC-mismatched M SCs and facilitate allogeneic MSC therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: March 8, 2021

2021 journal article

The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence

OSTEOARTHRITIS AND CARTILAGE, 29(3), 402–412.

By: M. Copp n, M. Flanders  n, R. Gagliardi n, J. Gilbertie n, G. Sessions *, S. Chubinskaya*, R. Loeser *, L. Schnabel n, B. Diekman n

author keywords: SA-beta-gal; DNA damage; Osteoarthritis; Aging; TGF- beta 1; bFGF
MeSH headings : Animals; Ankle Joint; Cartilage, Articular / cytology; Cartilage, Articular / drug effects; Cartilage, Articular / metabolism; Cellular Senescence / drug effects; Cellular Senescence / genetics; Chemokine CCL2 / drug effects; Chemokine CCL2 / genetics; Chondrocytes / drug effects; Chondrocytes / metabolism; Cyclin-Dependent Kinase Inhibitor p16 / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; DNA Damage / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Histones / drug effects; Histones / metabolism; Horses; Humans; In Vitro Techniques; Inflammation / genetics; Insulin-Like Growth Factor Binding Protein 3 / drug effects; Insulin-Like Growth Factor Binding Protein 3 / genetics; Interleukin-6 / genetics; Matrix Metalloproteinase 13 / drug effects; Matrix Metalloproteinase 13 / genetics; Mitogens / pharmacology; Stifle; Transforming Growth Factor beta1 / pharmacology; beta-Galactosidase / drug effects; beta-Galactosidase / metabolism
TL;DR: Treatment of cartilage explants with mitogenic stimuli in the context of cellular damage reliably induces high levels of SA-β-gal activity and other senescence markers, which provides a physiologically relevant model system to investigate the mechanisms of senescences induction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 29, 2021

2020 journal article

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

NATURE COMMUNICATIONS, 11(1).

By: P. Dinh n, D. Paudel n, H. Brochu n , K. Popowski n , M. Gracieux n, J. Cores n, K. Huang n , M. Hensley n ...

MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Apoptosis / drug effects; Bleomycin / toxicity; Cell Proliferation; Disease Models, Animal; Exosomes / metabolism; Exosomes / transplantation; Humans; Idiopathic Pulmonary Fibrosis / chemically induced; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Idiopathic Pulmonary Fibrosis / therapy; Lung / cytology; Lung / metabolism; Lung Injury / chemically induced; Lung Injury / metabolism; Lung Injury / pathology; Lung Injury / therapy; Mesenchymal Stem Cells / metabolism; Mice; Myofibroblasts / cytology; Proteomics; Silicon Dioxide / toxicity; Spheroids, Cellular / metabolism
TL;DR: It is shown that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: March 23, 2020

2020 journal article

One health in regenerative medicine: report on the second Havemeyer symposium on regenerative medicine in horses

REGENERATIVE MEDICINE, 15(6), 1775–1787.

By: L. Fortier *, L. Goodrich *, I. Ribitsch, L. Schnabel n, D. Shepard*, A. Watts*, R. Smith *

author keywords: animal model; bone marrow concentrate; horse; interleukin-1 receptor antagonist protein; mesenchymal stem cell; platelet rich plasma; stem cell
MeSH headings : Animals; Cell Differentiation; Congresses as Topic; Horse Diseases / therapy; Horses; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / cytology; One Health; Regenerative Medicine
TL;DR: Findings from a workshop on the development of translational regenerative medicine in the equine field were disseminated and five themes emerged: stem cell characterization and tenogenic differentiation, interactions between mesenchymal stem cells, other cells and the environment, and clinical use of regenerative therapies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 31, 2020

2020 journal article

Platelet-rich plasma lysate displays antibiofilm properties and restores antimicrobial activity against synovial fluid biofilms in vitro

JOURNAL OF ORTHOPAEDIC RESEARCH, 38(6), 1365–1374.

By: J. Gilbertie n, T. Schaer *, A. Schubert n, M. Jacob n, S. Menegatti n , R. Lavoie n, L. Schnabel n

author keywords: biofilms; equine model; infectious arthritis; platelet-rich plasma; Staphylococcus aureus
MeSH headings : Aminoglycosides / pharmacology; Animals; Anti-Bacterial Agents / pharmacology; Arthritis, Infectious / drug therapy; Biofilms / drug effects; Female; Horses; Male; Molecular Weight; Platelet-Rich Plasma; Synovial Fluid / microbiology
TL;DR: Overall, PRP‐L exhibited synergism with amikacin against aminoglycoside tolerant biofilm aggregates with greater activity against gram‐positive bacteria, which could lead to a decrease in morbidity and mortality associated with infectious arthritis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: January 27, 2020

2019 article

5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms

CHEMBIOCHEM, Vol. 12.

By: B. Frohock n, J. Gilbertie n, J. Daiker n, L. Schnabel n & J. Pierce n 

MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / pharmacology; Benzylidene Compounds / pharmacology; Biofilms / drug effects; Drug Synergism; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Oxazolidinones / pharmacology; Staphylococcus aureus / physiology; Structure-Activity Relationship
TL;DR: An expanded set of 5‐benzylidene‐4‐oxazolidinones is reported that is able to inhibit the formation of Staphylococcus aureus biofilms, disperse preformed biofilm, and are able to significantly reduce the bacterial load in a robust collagen‐matrix model of biofilm infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: January 13, 2020

2019 journal article

Effects of acellular equine amniotic allografts on the healing of experimentally induced full-thickness distal limb wounds in horses

VETERINARY SURGERY, 48(8), 1416–1428.

By: A. Fowler n, J. Gilbertie  n, V. Watson*, T. Prange n, J. Osborne n & L. Schnabel n

MeSH headings : Allografts; Amnion; Animals; Bandages / veterinary; Granulation Tissue / physiology; Horse Diseases / therapy; Horses / injuries; Prospective Studies; Skin / injuries; Skin / pathology; Wound Healing / physiology; Wounds and Injuries / therapy; Wounds and Injuries / veterinary
TL;DR: Application of eAM resulted in increased granulation tissue production while maintaining appropriate healing of experimental wounds and is likely most beneficial for substantial wounds in which expedient production of large amounts ofgranulation tissue is desirable. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 26, 2019

2019 journal article

Equine or porcine synovial fluid as a novel ex vivo model for the study of bacterial free-floating biofilms that form in human joint infections

PLOS ONE, 14(8).

By: J. Gilbertie  n, L. Schnabel n, N. Hickok *, M. Jacob n, B. Conlon *, I. Shapiro *, J. Parvizi *, T. Schaer *

MeSH headings : Animals; Arthritis / microbiology; Arthritis / pathology; Biofilms / growth & development; Disease Models, Animal; Horses; Humans; Staphylococcal Infections / microbiology; Staphylococcal Infections / pathology; Staphylococcus aureus / physiology; Swine; Synovial Fluid / microbiology
TL;DR: Staphylococcus aureus and other bacterial pathogens adapt the same biofilm aggregate phenotype with significant antimicrobial tolerance in both equine and porcine synovial fluid, analogous to human synovIAL fluid, to identify novel drug targets for treatment of prevention of these difficult to treat infectious diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: September 30, 2019

2019 journal article

Oral reserpine administration in horses results in low plasma concentrations that alter platelet biology

EQUINE VETERINARY JOURNAL, 51(4), 537–543.

By: J. Gilbertie  n, J. Davis*, G. Davidson n, A. McDonald n, J. Schirmer n & L. Schnabel n

author keywords: horse; reserpine; pharmacokinetics; tranquilisation; platelets; hypercoagulability
MeSH headings : Administration, Oral; Adrenergic Uptake Inhibitors / administration & dosage; Adrenergic Uptake Inhibitors / blood; Adrenergic Uptake Inhibitors / pharmacokinetics; Adrenergic Uptake Inhibitors / pharmacology; Animals; Area Under Curve; Blood Platelets / drug effects; Female; Half-Life; Horses / blood; Male; Reserpine / administration & dosage; Reserpine / blood; Reserpine / pharmacokinetics; Reserpine / pharmacology
TL;DR: Oral reserpine demonstrates low plasma concentrations and a prolonged half-life in horses and is likely due to serotonin release and re-uptake which primes platelets for activation and thromboxane B2 release. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 22, 2019

2018 review

Diagnosis and management of proximal sesamoid bone fractures in the horse

[Review of ]. EQUINE VETERINARY EDUCATION, 30(8), 450–455.

By: L. Schnabel n & W. Redding n

author keywords: horse; proximal sesamoid bone; fracture; arthroscopy
TL;DR: Fractures of the proximal sesamoid bones (PSBs) range in severity from simple to complex and comminuted and can be articular or nonarticular and carry a fair to guarded prognosis for return to racing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Gram-negative multi-drug resistant bacteria influence survival to discharge for horses with septic synovial structures: 206 Cases (2010-2015)

VETERINARY MICROBIOLOGY, 226, 64–73.

By: J. Gilbertie  n, L. Schnabel n, D. Stefanovski, D. Kelly, M. Jacob n & T. Schaer

author keywords: Septic synovitis; Infectious arthritis; Equine; Multi-drug resistance (MDR); Fluoroquinolones; Gram-negative bacteria
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Arthritis, Infectious / microbiology; Arthritis, Infectious / veterinary; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae / drug effects; Enterobacteriaceae Infections / mortality; Enterobacteriaceae Infections / veterinary; Gram-Negative Bacteria / drug effects; Gram-Negative Bacterial Infections / mortality; Gram-Negative Bacterial Infections / veterinary; Horse Diseases / microbiology; Horse Diseases / mortality; Horses; Hospitals, Animal; Microbial Sensitivity Tests; Patient Discharge / statistics & numerical data; Pseudomonas aeruginosa / drug effects; Staphylococcus / drug effects; Synovial Fluid / cytology; Synovial Fluid / microbiology; Synovitis / microbiology; Synovitis / veterinary
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: December 3, 2018

2018 journal article

Inflammatory licensed equine MSCs are chondroprotective and exhibit enhanced immunomodulation in an inflammatory environment

STEM CELL RESEARCH & THERAPY, 9.

By: J. Cassano *, L. Schnabel n, M. Goodale* & L. Fortier *

author keywords: Mesenchymal stem cells; Immunomodulation; Inflammatory licensing; Licensing; Polarization; Regenerative medicine
MeSH headings : Animals; Cells, Cultured; Chondrocytes / metabolism; Cytokines / genetics; Cytokines / metabolism; Extracellular Matrix Proteins / genetics; Extracellular Matrix Proteins / metabolism; Female; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / metabolism; Histocompatibility Antigens Class II / genetics; Histocompatibility Antigens Class II / metabolism; Horses; Immunomodulation; Macrophages / immunology; Male; Mesenchymal Stem Cells / immunology
TL;DR: In-vitro licensing prior to therapeutic application could result in a more predictable immunomodulatory and reparative response to MSC therapy compared to in-vivo inflammatory licensing by the recipient environment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Pooled Platelet-Rich Plasma Lysate Therapy Increases Synoviocyte Proliferation and Hyaluronic Acid Production While Protecting Chondrocytes From Synoviocyte-Derived Inflammatory Mediators

FRONTIERS IN VETERINARY SCIENCE, 5.

By: J. Gilbertie  n, J. Long n, A. Schubert n, A. Berglund n, T. Schaer * & L. Schnabel n

author keywords: platelet-rich plasma lysate; osteoarthritis; IL-1 beta; LPS; HA; collagen type II; aggrecan; MMP-13
TL;DR: The results of this study support continued investigation into the use of pooled PRP-L for the treatment of osteoarthritis and warrant further in-vitro studies to discern the mechanisms of action of PRp-L. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: December 17, 2018

2018 journal article

The immunomodulatory function of equine MSCs is enhanced by priming through an inflammatory microenvironment or TLR3 ligand

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 195, 33–39.

By: J. Cassano *, L. Schnabel n, M. Goodale* & L. Fortier *

author keywords: Mesenchymal stem cells; MSC; Immunomodulation; TLR; Polarization; Regenerative medicine
MeSH headings : Animals; Coculture Techniques / veterinary; Female; Gene Expression Regulation; Horses / immunology; Immunomodulation / immunology; Immunomodulation / physiology; Inflammation / immunology; Inflammation / physiopathology; Inflammation / veterinary; Lymphocytes / immunology; Lymphocytes / physiology; Macrophages / immunology; Macrophages / physiology; Male; Mesenchymal Stem Cells / immunology; Mesenchymal Stem Cells / physiology; T-Lymphocytes / immunology; T-Lymphocytes / physiology; Toll-Like Receptor 3 / physiology
TL;DR: The results suggest that MSCs can be activated by a variety of inflammatory stimuli, but the recipient injured tissue bed in chronic injuries may not contain sufficient inflammatory signals to activate MSC immunomodulatory function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Allogeneic major histocompatibility complex-mismatched equine bone marrow-derived mesenchymal stem cells are targeted for death by cytotoxic anti-major histocompatibility complex antibodies

EQUINE VETERINARY JOURNAL, 49(4), 539–544.

By: A. Berglund n & L. Schnabel n

author keywords: horse; mesenchymal stem cell; allogeneic; major histocompatibility complex-mismatched; antibody response; complement-dependent cytotoxicity
MeSH headings : Animals; Antibodies / immunology; Antibody Formation / immunology; Bone Marrow; Bone Marrow Cells / cytology; Bone Marrow Cells / immunology; Horses; Major Histocompatibility Complex / immunology; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / immunology
TL;DR: The cytotoxic antibody response induced in recipient horses following injection with donor MHC‐mismatched MSCs is capable of killing donor MSCS in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Effect of bone marrow-derived mesenchymal stem cells and stem cell supernatant on equine corneal wound healing in vitro

Stem Cell Research & Therapy, 8(1).

By: A. Sherman n, B. Gilger n , A. Berglund n & L. Schnabel n

author keywords: Mesenchymal stem cells; Equine; Corneal wound healing; Corneal stromal cells/fibroblasts; Scratch assay; TGF-beta 1
MeSH headings : Animals; Biomarkers / metabolism; Bone Marrow Cells / cytology; Corneal Injuries / pathology; Corneal Injuries / therapy; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor / metabolism; Female; Flow Cytometry; Horses; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Transforming Growth Factor beta1 / metabolism; Wound Healing
TL;DR: The significant decrease in scratch area in equine corneal fibroblast cultures treated with autologous BM-MSCs compared to MSC-Sp or control treatments suggests that BM- MSCs may substantially improve corNEal wound healing in horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2016 journal article

Navigational ultrasound imaging: A novel imaging tool for aiding interventional therapies of equine musculoskeletal injuries

EQUINE VETERINARY JOURNAL, 48(2), 195–200.

By: M. Lustgarten n, W. Redding n, L. Schnabel n, T. Prange n & G. Seiler n

author keywords: horse; navigational ultrasound imaging; fusion imaging; musculoskeletal; MRI
MeSH headings : Animals; Forelimb; Hindlimb; Horse Diseases / diagnosis; Horse Diseases / diagnostic imaging; Horse Diseases / surgery; Horses; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging / veterinary; Musculoskeletal Diseases / diagnostic imaging; Musculoskeletal Diseases / pathology; Musculoskeletal Diseases / surgery; Musculoskeletal Diseases / veterinary; Tomography, X-Ray Computed / veterinary; Ultrasonography
TL;DR: Navigational ultrasound imaging is a complementary imaging modality that can be used for the treatment of equine soft tissue musculoskeletal injuries diagnosed with MRI and is considered successful based on the authors' criteria. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Equine allogeneic bone marrow-derived mesenchymal stromal cells elicit antibody responses in vivo

STEM CELL RESEARCH & THERAPY, 6.

By: L. Pezzanite *, L. Fortier *, D. Antczak*, J. Cassano *, M. Brosnahan *, D. Miller *, L. Schnabel n

MeSH headings : Animals; Antibodies / immunology; Antibody Formation / immunology; Bone Marrow Cells / cytology; Bone Marrow Cells / immunology; Female; Horses; Inflammation / immunology; Major Histocompatibility Complex / immunology; Male; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / immunology; Transplantation, Homologous / methods
TL;DR: Four recipient horses had high-titered anti-ELA-A2 antibody responses resulting in greater than 80% donor PBL death in the microcytotoxicity assays and one of these horses also developed antibodies that cross-reacted when tested on lymphocyte targets from a horse with an unrelated MHC type. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Mesenchymal Stem Cell Therapy: Clinical Progress and Opportunities for Advancement

Current Pathobiology Reports, 3(1), 1–7.

By: J. Cassano *, L. Schnabel n, A. Betancourt*, D. Antczak* & L. Fortier *

TL;DR: A polarization paradigm where different priming stimuli, reflective of an injured tissue, induce either a pro-inflammatory or immunosuppressive MSC phenotype, provides the potential for manipulating MSCs to obtain more predictable clinical effects. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2014 journal article

Equine bone marrow-derived mesenchymal stromal cells are heterogeneous in MHC class II expression and capable of inciting an immune response in vitro

STEM CELL RESEARCH & THERAPY, 5.

By: L. Schnabel n, L. Pezzanite *, D. Antczak*, M. Felippe* & L. Fortier *

MeSH headings : Animals; Cells, Cultured; Genes, MHC Class II / genetics; Genes, MHC Class II / immunology; Horses; Immunophenotyping; Interferon-gamma / pharmacology; Leukocytes / immunology; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / immunology
TL;DR: MSCs should be confirmed as MHC class II negative before allogeneic application, and it must be considered that even M HC class II-negative MSCs could upregulate MHCclass II expression if implanted into an area of active inflammation, as demonstrated with in vitro stimulation with IFN-γ. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Induced pluripotent stem cells have similar immunogenic and more potent immunomodulatory properties compared with bone marrow-derived stromal cells in vitro

REGENERATIVE MEDICINE, 9(5), 621–635.

By: L. Schnabel n, C. Abratte*, J. Schimenti *, M. Felippe*, J. Cassano *, T. Southard *, J. Cross *, L. Fortier *

author keywords: allogeneic stem cell therapy; immunogenicity; immunomodulatory; induced pluripotent stem cell; mesenchymal stromal cell; transplantation medicine
MeSH headings : Animals; Cell Culture Techniques; Cell Differentiation; Cytokines / metabolism; Female; Immunomodulation; Induced Pluripotent Stem Cells / immunology; Male; Mesenchymal Stem Cells / immunology; Mice; Mice, Inbred C57BL
TL;DR: These results provide important information when considering the use of iPSCs in place of MSCs in both regenerative and transplantation medicine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Therapeutic use of stem cells in horses: Which type, how, and when?

The Veterinary Journal, 197(3), 570–577.

By: L. Schnabel*, L. Fortier *, C. Wayne McIlwraith * & K. Nobert

author keywords: Stem cells; Equine musculoskeletal disorders; Tendonitis; Osteoarthritis; FDA
MeSH headings : Animals; Horse Diseases / therapy; Horses; Stem Cell Transplantation / veterinary
TL;DR: Clinicians must be aware of the limitation in current knowledge regarding stem cells, and the impending regulatory laws that may limit the use of equine stem cells in clinical patients. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: February 24, 2020

2012 journal article

Cell- and gene-based approaches to tendon regeneration

Journal of Shoulder and Elbow Surgery, 21(2), 278–294.

By: A. Nixon, A. Watts & L. Schnabel*

author keywords: Tendon; rotator cuff; shoulder; MSC; stem cells; gene therapy; regeneration
MeSH headings : Animals; Forecasting; Genetic Therapy / methods; Genetic Therapy / trends; Humans; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cell Transplantation / trends; Recovery of Function; Regeneration / physiology; Rotator Cuff Injuries; Tendon Injuries / therapy; Tendons / physiology; Tensile Strength; Treatment Outcome; Wound Healing / physiology
TL;DR: Cell- and gene-enhanced cell research for tendon repair is summarized and future directions for rotator cuff repair using biologic composites are provided. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2009 journal article

Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons

Journal of Orthopaedic Research, 27(10), 1392–1398.

By: L. Schnabel*, M. Lynch *, M. van der Meulen *, A. Yeager*, M. Kornatowski* & A. Nixon*

author keywords: mesenchymal stem cells; IGF-I; gene therapy; tendinitis; in vivo
MeSH headings : ADAM Proteins / metabolism; ADAMTS4 Protein; Animals; Biomechanical Phenomena; Cell- and Tissue-Based Therapy / methods; Cell- and Tissue-Based Therapy / veterinary; Collagen Type I / metabolism; Collagen Type III / metabolism; Extracellular Matrix Proteins / metabolism; Female; Genetic Therapy / methods; Genetic Therapy / veterinary; Glycoproteins / metabolism; Horse Diseases / metabolism; Horse Diseases / pathology; Horse Diseases / therapy; Horses; Insulin-Like Growth Factor I / genetics; Insulin-Like Growth Factor I / metabolism; Male; Matrilin Proteins; Matrix Metalloproteinase 13 / metabolism; Matrix Metalloproteinase 3 / metabolism; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cell Transplantation / veterinary; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Procollagen N-Endopeptidase / metabolism; Tendinopathy / metabolism; Tendinopathy / therapy; Tendinopathy / veterinary; Tendons / diagnostic imaging; Tendons / metabolism; Tendons / pathology; Ultrasonography
TL;DR: A benefit to the use of MSCs and AdIGF‐MSCs for the treatment of tendinitis is indicated, following previous work that demonstrated the value of insulin‐like growth factor‐I to stimulate cellular proliferation and tendon fiber deposition in the core lesion of Tendinitis. (via Semantic Scholar)
Source: Crossref
Added: December 29, 2020

2007 journal article

Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons

Journal of Orthopaedic Research, 25(2), 230–240.

By: L. Schnabel*, H. Mohammed*, B. Miller *, W. McDermott*, M. Jacobson*, K. Santangelo *, L. Fortier *

author keywords: platelet rich plasma (PRP); tendonitis; collagen; cartilage oligomeric matrix protein (COMP); matrix metalloproteinase (MMP)
MeSH headings : Animals; Becaplermin; Collagen / genetics; Collagen / metabolism; DNA / genetics; DNA / metabolism; Dose-Response Relationship, Drug; Extracellular Matrix Proteins / genetics; Extracellular Matrix Proteins / metabolism; Gene Expression Regulation / physiology; Glycoproteins / genetics; Glycoproteins / metabolism; Horses; Insulin-Like Growth Factor I / genetics; Insulin-Like Growth Factor I / metabolism; Matrilin Proteins; Metabolism / genetics; Metabolism / physiology; Platelet-Derived Growth Factor / genetics; Platelet-Derived Growth Factor / metabolism; Platelet-Rich Plasma / physiology; Proto-Oncogene Proteins c-sis; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tendinopathy / drug therapy; Tendons / metabolism; Tissue Culture Techniques; Transforming Growth Factor beta1 / genetics; Transforming Growth Factor beta1 / metabolism
TL;DR: The findings of this study support in vivo investigation of PRP as an autogenous, patient‐side treatment for tendonitis as well as other blood products tested. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

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