Works (145)

Updated: March 24th, 2025 08:43

2025 article

Comparison of a dorsolateral approach and a dorsomedial approach to access the medial malleolus of the distal tibia in horses

VETERINARY SURGERY, Vol. 3.

By: M. Guerra n, L. Schnabel n & C. Jacobs n

topics (OpenAlex): Veterinary Equine Medical Research; Tendon Structure and Treatment; Shoulder Injury and Treatment
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 11, 2025

2025 journal article

Early degenerative changes are different between partial and complete anterior cruciate ligament injury and associate with joint instability in a skeletally immature porcine model

Osteoarthritis and Cartilage, 33(2), 302–312.

By: D. Howe n, J. Thompson n, S. Teeter n, M. Easson n, O. Barlow n, E. Griffith n, L. Schnabel n, J. Spang*, M. Fisher n

author keywords: Anterior cruciate ligament; Osteoarthritis; Biomechanics; Pediatrics; Orthopedics
topics (OpenAlex): Knee injuries and reconstruction techniques; Total Knee Arthroplasty Outcomes; Orthopedic Surgery and Rehabilitation
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: February 10, 2025

2025 journal article

Equine neutrophils selectively release neutrophil extracellular traps in response to chemical and bacterial agonists

FRONTIERS IN VETERINARY SCIENCE, 12.

By: B. Sheahan n, A. Schubert n, W. Schubert*, M. Sheats n, L. Schnabel n & J. Gilbertie n

author keywords: equine; neutrophils; neutrophil extracellular traps; citrullinated histones; NADPH-oxidase pathway; autophagy
topics (OpenAlex): Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Nitric Oxide and Endothelin Effects; Immune Response and Inflammation
Sources: Web Of Science, NC State University Libraries
Added: March 17, 2025

2024 article

A NOVEL MATRIKINE STIMULATED EQUINE SYNOVIAL FIBROBLAST AND CHONDROCYTE COCULTURE MODEL OF OSTEOARTHRITIS: A PROPOSED ALTERNATIVE TO TRADITIONAL LPS AND IL-1B MODELS

Gagliardi, R., Loeser, R. F., & Schnabel, L. (2024, June). OSTEOARTHRITIS AND CARTILAGE, Vol. 32, pp. 780–781.

By: R. Gagliardi*, R. Loeser & L. Schnabel*

topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Bone Metabolism and Diseases; Spine and Intervertebral Disc Pathology
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2024

2024 conference paper

A novel matrikine stimulated equine synovial fibroblast and chondrocyte co-culture model of osteoarthritis: a proposed alternative to traditional LPS and Il-1b models

OARSI 2024 World Congress on Osteoarthritis. Presented at the OARSI 2024 World Congress on Osteoarthritis.

By: R. Gagliardi, R. Loeser & L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2024 journal article

Animal drug shortages limit veterinary therapeutic options and introduce artifacts in antimicrobial sales reporting

Journal of the American Veterinary Medical Association, 262(4), 1–4.

By: R. Robbins*, R. Singer, G. Innes*, P. Plummer*, M. Apley*, P. Gaunt, M. Papich, J. Granick ...

topics (OpenAlex): Pharmaceutical Economics and Policy; Pharmaceutical studies and practices; Pharmaceutical Quality and Counterfeiting
TL;DR: Clinicians' professional perspective regarding how drug shortages, specifically that of penicillin, might contribute to misconstrued patterns in antimicrobial use and what can be done by veterinarians and the FDA to minimize the impact of an antimicrobial drug shortage on animal health and well-being are provided. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 27, 2024

2024 journal article

Controlled Stiffness of Direct-Write, Near-Field Electrospun Gelatin Fibers Generates Differences in Tenocyte Morphology and Gene Expression

Journal of Biomechanical Engineering, 146(9).

By: Z. Davis n, D. Koch n, S. Watson n, G. Scull n, A. Brown n, L. Schnabel n, M. Fisher n

topics (OpenAlex): Tendon Structure and Treatment; Sports injuries and prevention; Shoulder Injury and Treatment
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: May 17, 2024

2024 article

Editorial: Links between regenerative medicine and immunotherapy: how cellular therapies modulate immune responses for improved outcomes

Pezzanite, L., Barrachina, L., & Schnabel, L. (2024, July 26). FRONTIERS IN VETERINARY SCIENCE, Vol. 11.

By: L. Pezzanite*, L. Barrachina* & L. Schnabel n

author keywords: regenerative therapy; biologic therapy; mesenchymal stem cell; platelet lysate; immunotherapy
topics (OpenAlex): Biomedical Ethics and Regulation
Sources: Web Of Science, NC State University Libraries
Added: August 19, 2024

2024 conference paper

Equity and Equine Medicine

North Carolina Veterinary Conference. Presented at the North Carolina Veterinary Conference, Raleigh, NC.

By: L. Schnabel & L. Castro

Source: NC State University Libraries
Added: February 16, 2025

2024 journal article

Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity

Bioorganic & Medicinal Chemistry Letters, 99, 129609.

By: M. Nie n, M. Alejandro Valdes-Pena n, B. Frohock n, E. Smits n, J. Daiker n, J. Gilbertie n, L. Schnabel n, J. Pierce n

author keywords: Natural products; Antibiotics; Antimicrobial resistance; Biofilms; 2 3-pyrrolidinedione
topics (OpenAlex): Antimicrobial Peptides and Activities; Chemical Synthesis and Analysis; Phenothiazines and Benzothiazines Synthesis and Activities
TL;DR: A new library of 2,3-pyrrolidinedione analogues is reported that expands on the previous report on the antimicrobial studies of this heterocyclic scaffold and displayed antibiofilm properties and represent intriguing scaffolds for further optimization and development. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries, Web Of Science
Added: January 7, 2024

2024 journal article

Fighting fibrin with fibrin: Vancomycin delivery into coagulase‐mediated <i>Staphylococcus aureus</i> biofilms via fibrin‐based nanoparticle binding

Journal of Biomedical Materials Research Part A, 112(12), 2071–2085.

By: G. Scull n, A. Aligwekwe n, Y. Rey n, D. Koch n, K. Nellenbach n, A. Sheridan n, S. Pandit n, J. Sollinger n ...

author keywords: biofilm; dermal infection; fibrin; nanoparticle; Staphylococcus aureus; vancomycin
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial Resistance in Staphylococcus; Oral microbiology and periodontitis research
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 24, 2024

2024 journal article

IL-1β + TGF-β2 dual-licensed mesenchymal stem cells have reduced major histocompatibility class I expression and positively modulate tenocyte migration, metabolism, and gene expression

Journal of the American Veterinary Medical Association, 262(S1), S61–S72.

By: D. Koch n, A. Froneberger n, A. Berglund n, S. Connard n, A. Souther n & L. Schnabel n

author keywords: mesenchymal stem cell; tendon; MHC class I; IL-1 beta; TGF-beta 2
topics (OpenAlex): Tendon Structure and Treatment; Wound Healing and Treatments; Burn Injury Management and Outcomes
Sources: Web Of Science, NC State University Libraries, Crossref
Added: July 22, 2024

2024 article proceedings

Initial Investigation into the Effects of Tissue Plasminogen Activator on Intrasynovial Tenocytes In Vitro

Presented at the 2024 American College of Veterinary Sports Medicine and Rehabilitation Symposium Scientific/Clinical Abstract Sessions.

By: S. Connard n, D. Koch n, C. Coleman n, A. Froneberger n, J. Long n & L. Schnabel n

topics (OpenAlex): Tendon Structure and Treatment; Sports injuries and prevention; Orthopedic Surgery and Rehabilitation
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 10, 2025

2024 journal article

Matrikine stimulation of equine synovial fibroblasts and chondrocytes results in an in vitro osteoarthritis phenotype

Journal of Orthopaedic Research, 43(2), 292–303.

By: R. Gagliardi n, D. Koch n, R. Loeser* & L. Schnabel n

author keywords: equine; fibronectin fragments; in vitro; osteoarthritis
topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Tendon Structure and Treatment; Veterinary Equine Medical Research
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 2, 2024

2024 conference paper

Mitigating the Risk of Corticosteroid-Induced Laminitis

Association of Equine Practitioners (AAEP) Convention and Trade Show. Presented at the Association of Equine Practitioners (AAEP) Convention and Trade Show, Orlando, FL.

By: L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2024 journal article

No correlation found between palpation and ultrasound for evaluation of effusion in the medial femorotibial and femoropatellar joint compartments of horses

Journal of the American Veterinary Medical Association, 262(4), 476–480.

By: J. Ruff n, S. Tufts n, J. Robertson n, C. Horne n, L. Schnabel n & C. Jacobs n

author keywords: ultrasound; palpation; lameness; equine; stifle
topics (OpenAlex): Veterinary Equine Medical Research; Shoulder Injury and Treatment; Hip disorders and treatments
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 19, 2024

2024 article proceedings

Palpation and Ultrasound Assessment of Naturally Occurring Effusion of the Equine Stifle

Presented at the 2024 American College of Veterinary Sports Medicine and Rehabilitation Symposium Scientific/Clinical Abstract Sessions.

By: J. Ruff n, S. Tufts n, J. Robertson n, C. Horne n, L. Schnabel n & C. Jacobs n

topics (OpenAlex): Veterinary Equine Medical Research; Veterinary Orthopedics and Neurology
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 10, 2025

2024 journal article

Pyrrolidine-2,3-diones: heterocyclic scaffolds that inhibit and eradicate <i>S. aureus</i> biofilms

Chemical Communications, 60(81), 11540–11543.

By: M. Valdes-Pena n, A. Ratchford n, M. Nie n, L. Schnabel n & J. Pierce n

topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial Peptides and Activities; Antimicrobial agents and applications
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: September 30, 2024

2024 journal article

Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs

Frontiers in Pharmacology, 15.

By: A. Moatti n, S. Connard n, N. De Britto n, W. Dunn*, S. Rastogi n, M. Rai, L. Schnabel n, F. Ligler* ...

author keywords: intratympanic; inner ear; fluid simulation; round window membrane; pigs; swine; pharmacokinetics
topics (OpenAlex): Vestibular and auditory disorders; Hearing, Cochlea, Tinnitus, Genetics; Ear Surgery and Otitis Media
TL;DR: The potential of using pigs as a large animal model for studying inner ear pharmacokinetic studies of the inner ear using pigs is demonstrated and the diffusion time and drug concentrations reported align closely with the limited data available from human studies. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: February 19, 2024

2024 conference paper

Systemic Absorption of Triamcinolone Acetonide Following Intrasynovial and Extrasynovial Articular Injection

AAEP Convention. Presented at the AAEP Convention.

By: K. Hallowell, K. Dembek, C. Horne, H. Knych, K. Messenger & L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2024 journal article

Systemic absorption of triamcinolone acetonide is increased from intrasynovial versus extrasynovial sites and induces hyperglycemia, hyperinsulinemia, and suppression of the hypothalamic-pituitary-adrenal axis

Frontiers in Veterinary Science, 11.

By: K. Hallowell n, K. Dembek n, C. Horne n, H. Knych*, K. Messenger n & L. Schnabel n

author keywords: corticosteroids; triamcinolone; insulin; cortisol; sacroiliac; horse
topics (OpenAlex): Veterinary Equine Medical Research; Adrenal Hormones and Disorders; Pharmacology and Obesity Treatment
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 11, 2024

2024 journal article

Temperature has a greater effect than salinity on microbial survival in saltwater from a single equine hydrotherapy unit

American Journal of Veterinary Research, 85(11).

By: S. Tufts n, M. Aworh n, K. Love n, E. Treece n, C. Horne n, M. Jacob n, L. Schnabel n

author keywords: saltwater; hydrotherapy; temperature; bacterial growth; equine
topics (OpenAlex): Diabetic Foot Ulcer Assessment and Management; Wound Healing and Treatments
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: November 18, 2024

2024 journal article

Ultrasoft platelet-like particles stop bleeding in rodent and porcine models of trauma

Science Translational Medicine, 16(742).

By: K. Nellenbach n, E. Mihalko n, S. Nandi n, D. Koch n, J. Shetty*, L. Moretti*, J. Sollinger n, N. Moiseiwitsch n ...

topics (OpenAlex): Trauma, Hemostasis, Coagulopathy, Resuscitation; Hemostasis and retained surgical items; Blood transfusion and management
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 22, 2024

2024 conference paper

Understanding the Potent Antibiofilm Activity of Natural Product-derived Lipoxazolidinones

North Carolina Branch ASM Annual Meeting and Research Symposium. Presented at the North Carolina Branch ASM Annual Meeting and Research Symposium, Wilmington, NC.

By: A. Ratchford, J. Pierce & L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2023 conference paper

A Novel Equine In Vitro Model of Osteoarthritis Utilizing Fibronectin Fragment (FN7-10) Stimulated Synovial Fibroblasts and Chondrocytes

ACVS Surgery Summit 2023. Poster presented at the ACVS Surgery Summit 2023.

By: R. Gagliardi, D. Koch, R. Loeser & L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2023 conference paper

Advances in the diagnosis of tendon and ligament injuries

Florida Association of Equine Practitioners (FAEP) Promoting Excellence Symposium. Presented at the Florida Association of Equine Practitioners (FAEP) Promoting Excellence Symposium, West Palm Beach, FL.

By: L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2023 journal article

Antimicrobial Properties of Equine Stromal Cells and Platelets and Future Directions

Veterinary Clinics of North America: Equine Practice, 39(3), 565–578.

author keywords: Horse; Antimicrobial; Regenerative; Biologic; Therapies; Mesenchymal stromal cells; Platelets
topics (OpenAlex): Periodontal Regeneration and Treatments; Mesenchymal stem cell research; Wound Healing and Treatments
TL;DR: Mechanisms by which biological therapies exert antimicrobial effects are discussed, as well as potential applications and challenges in clinical implementation in equine practice. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: November 27, 2023

2023 conference paper

Back Pain in the Horse: Diagnosis and Management

North Carolina Veterinary Conference. Presented at the North Carolina Veterinary Conference, Raleigh, NC.

By: L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2023 conference paper

Biofilm formation in septic synovitis and novel therapies

American College of Veterinary Surgeons Surgery Summit. Presented at the American College of Veterinary Surgeons Surgery Summit, Louisville, KY.

By: L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2023 conference paper

Common causes of fetlock pain, management, and prognosis

The Equine Practice Company Lameness Program. Presented at the The Equine Practice Company Lameness Program.

By: L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2023 journal article

Considerations for the Use of Biologic and Regenerative Therapies in Equine Practice

Veterinary Clinics of North America: Equine Practice, 39(3), xiii-xiv.

By: L. Schnabel n

topics (OpenAlex): Tissue Engineering and Regenerative Medicine
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: November 27, 2023

2023 conference paper

Degenerative Changes Are Associated with Joint Stability after Partial and Complete ACL Injury in a Skeletally Immature Porcine Model

`ORS (Orthopaedic Research Society) Annual Meeting 2023. Presented at the ORS (Orthopaedic Research Society) Annual Meeting 2023.

By: D. Howe, J. Thompson, L. Schnabel, J. Spang & M. Fisher

Source: NC State University Libraries
Added: February 16, 2025

2023 journal article

Effect of gentamicin on <scp>CD3</scp>+ T‐lymphocyte proliferation for treatment of equine recurrent uveitis: An in vitro study

Veterinary Ophthalmology, 26(4), 347–354.

By: H. Smith n, A. Berglund n, J. Robertson n, L. Schnabel n, R. McMullen*, B. Gilger n, A. Oh n

author keywords: autoimmune disease; equine recurrent uveitis; gentamicin; horse; immunology; intravitreal injection
topics (OpenAlex): Ocular Infections and Treatments; Mycobacterium research and diagnosis
TL;DR: Gentamicin had no effect on equine peripheral blood CD3+ T-lymphocyte cell viability and proliferation in concentrations ranging from "safe" to "retinotoxic" in relation to intravitreal injection volumes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: April 29, 2023

2023 conference paper

Enhanced Clotting in Synovial Fluid with Colloidal-Composite Gels for Partial Anterior Cruciate Ligament Tears

ORS (Orthopaedic Research Society) Annual Meeting 2023. Poster presented at the ORS (Orthopaedic Research Society) Annual Meeting 2023.

By: J. Thompson, G. Scull, L. Schnabel, M. Fisher & A. Brown

Source: NC State University Libraries
Added: February 16, 2025

2023 conference paper

Evaluating the safety and efficacy of allogeneic stem cell products: what do you need to know?

Locomotion in Practice 2023. Presented at the Locomotion in Practice 2023, Netherlands.

By: L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2023 conference paper

IL-1b and TGF-b2 dual licensed mesenchymal stem cells downregulate MHC I expression and enhance tendon fibroblast migration in vitro

ACVS Surgery Summit 2023. Poster presented at the ACVS Surgery Summit 2023.

By: D. Koch, A. Froneberger, A. Berglund, S. Connard, A. Souther & L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2023 journal article

Mesenchymal stem cell licensing: enhancing MSC function as a translational approach for the treatment of tendon injury

American Journal of Veterinary Research, 84(10), 1–8.

By: D. Koch n & L. Schnabel n

author keywords: mesenchymal stem cell; licensing; activation; tendon; MSC function
topics (OpenAlex): Tendon Structure and Treatment; Wound Healing and Treatments; Mesenchymal stem cell research
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 26, 2024

2023 article

Neo-natal castration leads to subtle differences in porcine anterior cruciate ligament morphology and function in adolescence

Thompson, J. D., Howe, D., Griffith, E. H., Schnabel, L. V., & Fisher, M. B. (2023, January 25).

topics (OpenAlex): Knee injuries and reconstruction techniques; Sports Performance and Training; Adhesion, Friction, and Surface Interactions
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: December 13, 2024

2023 conference paper

New Horizons in Viscosupplementation and Rehabilitation for the Treatment of Joint Disease

American Association of Equine Veterinary Technicians and Assistants Convention. Presented at the American Association of Equine Veterinary Technicians and Assistants Convention, San Diego, CA.

By: L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2023 conference paper

Orthobiologics for soft tissue injuries

American College of Veterinary Sports Medicine and Rehabilitation Symposium. Presented at the American College of Veterinary Sports Medicine and Rehabilitation Symposium, Charleston, SC.

By: L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2023 article proceedings

Pneumatic Compression Therapy Using the EQ Press Accelerates Lymphatic Flow in Healthy Equine Forelimbs as Determined by Lymphoscintigraphy

Presented at the 2023 American College of Veterinary Sports Medicine and Rehabilitation Symposium Scientific/Clinical Abstract Sessions.

By: D. Koch n, L. Schnabel n, J. Reynolds n & C. Berry n

topics (OpenAlex): Lymphatic System and Diseases; Veterinary Equine Medical Research; Body Contouring and Surgery
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 10, 2025

2023 journal article

Pneumatic compression therapy using the EQ Press accelerates lymphatic flow in healthy equine forelimbs as determined by lymphoscintigraphy

American Journal of Veterinary Research, 84(4), 1–6.

By: D. Koch n, L. Schnabel n, J. Reynolds n & C. Berry n

MeSH headings : Horses; Animals; Lymphoscintigraphy / veterinary; Technetium Tc 99m Sulfur Colloid; Lymph Nodes; Lymphedema / diagnostic imaging; Lymphedema / therapy; Lymphedema / veterinary; Forelimb / diagnostic imaging; Radiopharmaceuticals; Horse Diseases / pathology
topics (OpenAlex): Lymphatic System and Diseases; Lymphatic Disorders and Treatments; Effects of Vibration on Health
TL;DR: Pneumatic compression therapy as provided by an equine-specific device encouraged lymphatic flow in healthy, nonedematous equine forelimbs and data support further study of the EQ Press for pneumatic compressor therapy in horses clinically affected by lymphedema and lymphatic drainage disorders. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: May 22, 2023

2023 conference paper

Point-of-care biologics and viscoelastic therapies for the treatment of musculoskeletal injuries

Florida Association of Equine Practitioners (FAEP) Promoting Excellence Symposium. Presented at the Florida Association of Equine Practitioners (FAEP) Promoting Excellence Symposium, West Palm Beach, FL.

By: L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2023 journal article

Preclinical tendon and ligament models: Beyond the 3Rs (replacement, reduction, and refinement) to 5W1H (why, who, what, where, when, how)

Journal of Orthopaedic Research, 41(10), 2133–2162.

topics (OpenAlex): Tendon Structure and Treatment; Shoulder Injury and Treatment; Knee injuries and reconstruction techniques
Sources: Crossref, NC State University Libraries
Added: February 8, 2025

2023 conference paper

Rehabilitation and monitoring of tendon and ligament injuries

Florida Association of Equine Practitioners Promoting Excellence Symposium (FAEP). Presented at the Florida Association of Equine Practitioners Promoting Excellence Symposium (FAEP), West Palm Beach, FL.

By: L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2023 article proceedings

Systemic Absorption of Triamcinolone Acetonide following Intrasynovial and Extrasynovial Articular Injection

Presented at the 2023 American College of Veterinary Sports Medicine and Rehabilitation Symposium Scientific/Clinical Abstract Sessions.

By: K. Hallowell n, K. Dembek n, C. Horne n, H. Knych*, K. Messenger n & L. Schnabel n

topics (OpenAlex): Shoulder Injury and Treatment; Advanced machining processes and optimization; Musculoskeletal synovial abnormalities and treatments
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 10, 2025

2023 article

TGF-β downregulates antigen processing and presentation genes and MHC I surface expression through a Smad3-dependent mechanism

Berglund, A. K., Hinson, A. L., & Schnabel, L. V. (2023, February 1).

By: A. Berglund n, A. Hinson & L. Schnabel n

topics (OpenAlex): Immune Response and Inflammation; T-cell and B-cell Immunology
Source: ORCID
Added: February 6, 2025

2023 journal article

Use of mesenchymal stem cells for tendon healing in veterinary and human medicine: getting to the “core” of the problem through a one health approach

Journal of the American Veterinary Medical Association, 261(10), 1435–1442.

By: L. Schnabel n & D. Koch n

author keywords: mesenchymal stem cell; Achilles tendon; superficial digital flexor tendon; core lesion; one health
topics (OpenAlex): Tendon Structure and Treatment; Wound Healing and Treatments
TL;DR: Why the equine superficial digital flexor tendon core lesion might be considered optimal for stem cell delivery and stem cell interaction with the injury environment is reviewed and the concept of stem cell licensing for future evaluation is introduced. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: March 4, 2024

2023 conference paper

Use of stem cells for the treatment of musculoskeletal injuries: what type, how, and when?

Florida Association of Equine Practitioners (FAEP) Promoting Excellence Symposium. Presented at the Florida Association of Equine Practitioners (FAEP) Promoting Excellence Symposium, West Palm Beach, FL.

By: L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2023 conference paper

Variable stiffness Crosslinking method of aligned direct-write, near-field electrospun gelatin fibers alter stiffness, cytocompatibility, and increased cellular aspect ratios of tenocytes

ORS (Orthopaedic Research Society) Annual Meeting 2023. Poster presented at the ORS (Orthopaedic Research Society) Annual Meeting 2023.

By: Z. Davis, G. Scull, D. Koch, L. Schnabel, A. Brown & M. Fisher

Source: NC State University Libraries
Added: February 16, 2025

2023 conference paper

Viscoelastic therapies for osteoarthritis management

American College of Veterinary Sports Medicine and Rehabilitation Symposium. Presented at the American College of Veterinary Sports Medicine and Rehabilitation Symposium, Charleston, SC.

By: L. Schnabel

Source: NC State University Libraries
Added: February 16, 2025

2022 conference paper

A Model of Orthopedic Device-Related Infection Due to Staphylococcus aureus Biofilms

NCSU Litwack Research Day. Poster presented at the NCSU Litwack Research Day.

By: A. Souther, A. Ratchford, D. Koch & L. Schnabel

Source: NC State University Libraries
Added: February 23, 2025

2022 journal article

A Platelet-Rich Plasma-Derived Biologic Clears Staphylococcus aureus Biofilms While Mitigating Cartilage Degeneration and Joint Inflammation in a Clinically Relevant Large Animal Infectious Arthritis Model

Frontiers in Cellular and Infection Microbiology, 12.

By: J. Gilbertie n, T. Schaer*, J. Engiles*, G. Seiler n, B. Deddens n, A. Schubert n, M. Jacob n, D. Stefanovski* ...

author keywords: infectious arthritis; S; aureus; biofilm; antimicrobial; platelets; cartilage; synovium; synovial fluid
MeSH headings : Amikacin; Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Arthritis, Infectious / drug therapy; Biofilms; Biological Products; Disease Models, Animal; Horses; Inflammation; Platelet-Rich Plasma; Staphylococcal Infections / drug therapy; Staphylococcal Infections / veterinary; Staphylococcus aureus
topics (OpenAlex): Orthopedic Infections and Treatments; Periodontal Regeneration and Treatments; Rabies epidemiology and control
TL;DR: The results demonstrate the in vivo efficacy of AMK+BIO-PLY and represents a new approach to restore and potentiate antimicrobial activity against synovial fluid biofilms. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 20, 2022

2022 journal article

A call to action for veterinarians and partners in animal health to collect antimicrobial use data for the purposes of supporting medical decision-making and antimicrobial stewardship

Journal of the American Veterinary Medical Association, 260(8), 853–859.

By: V. Fajt, T. Lehenbauer, P. Plummer, R. Robbins, J. Scheftel, R. Singer, A. Canon, E. Frey* ...

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Anti-Infective Agents; Antimicrobial Stewardship; Clinical Decision-Making; Humans; Veterinarians
topics (OpenAlex): Bacterial Identification and Susceptibility Testing; Antibiotic Use and Resistance; Clostridium difficile and Clostridium perfringens research
TL;DR: A call to action for veterinarians and partners in animal health to collect antimicrobial use data for the purposes of supporting medical decision-making and antimicrobial stewardship. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 27, 2024

2022 conference paper

ACL Injury Impacts Long-Term Knee Function and Tissue Remodeling in a Skeletally Immature Porcine Model

ORS (Orthopaedic Research Society) Annual Meeting. Presented at the ORS (Orthopaedic Research Society) Annual Meeting.

By: D. Howe, J. Thompson, A. Bautista, L. Schnabel, J. Spang & M. Fisher

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Advances in the diagnosis and treatment of septic synovial structures

Maryland Delaware Veterinary Medical Association Annual Summer Conference. Presented at the Maryland Delaware Veterinary Medical Association Annual Summer Conference, Ocean City, MD.

By: L. Schnabel

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Advances in the diagnosis of tendon and ligament injuries

Maryland Delaware Veterinary Medical Association Annual Summer Conference. Presented at the Maryland Delaware Veterinary Medical Association Annual Summer Conference, Ocean City, MD.

By: L. Schnabel

Source: NC State University Libraries
Added: February 23, 2025

2022 journal article

Alterations to the synovial invaginations of the navicular bone are associated with pathology of both the navicular apparatus and distal interphalangeal joint when evaluated using high field MRI

Veterinary Radiology & Ultrasound, 64(1), 9–17.

By: T. McParland n, C. Horne n, J. Robertson n, L. Schnabel n & N. Nelson n

author keywords: distal sesamoid bone; foot; horse; imaging
MeSH headings : Animals; Horses; Retrospective Studies; Joints; Tarsal Bones / diagnostic imaging; Magnetic Resonance Imaging / veterinary; Foot; Horse Diseases
topics (OpenAlex): Veterinary Equine Medical Research; Tendon Structure and Treatment; Musculoskeletal synovial abnormalities and treatments
TL;DR: Findings suggest that primary DIPJ disease and NA pathology should be considered when noticing alterations to navicular synovial invaginations on MRI, which contrasts traditional views that synovials invagination abnormalities are indicative solely of NA pathology. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 22, 2022

2022 conference paper

Alterations to the synovial invaginations of the navicular bone are associated with pathology of both the navicular apparatus and distal interphalangeal joint when evaluated using magnetic resonance imaging

ACVS Surgery Summit. Presented at the ACVS Surgery Summit.

By: T. McParland, C. Horne, J. Robertson, L. Schnabel & N. Nelson

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Changes In Serum, But Not Synovial Fluid, Levels of Inflammatory Biomarker MCP-1 Are Correlated With Cartilage T2* Relaxation Times After ACL Injury In A Juvenile Porcine Model

ORS Annual Meeting. Presented at the ORS Annual Meeting.

By: D. Howe, J. Thompson, H. Wilcockson, L. Schnabel, L. Longobardi, J. Spang, B. Pietrosimone, M. Fisher

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Defining the Inflammatory Cytokine Profile In Acute Tendon Injury to Enhance Mesenchymal Stem Cell Therapy

NCSU Litwack Research Day 2022. Poster presented at the NCSU Litwack Research Day 2022.

By: I. Ellis, D. Koch, A. Berglund, K. Messenger, J. Gilbertie & L. Schnabel

Source: NC State University Libraries
Added: February 23, 2025

2022 journal article

Defining the profile: Characterizing cytokines in tendon injury to improve clinical therapy

Journal of Immunology and Regenerative Medicine, 16, 100059.

By: I. Ellis n, L. Schnabel n & A. Berglund n

topics (OpenAlex): Tendon Structure and Treatment; Exercise and Physiological Responses; Heat shock proteins research
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Sources: ORCID, Crossref, NC State University Libraries
Added: February 6, 2025

2022 conference paper

Demystifying stem cells and biologics in the joint disease challenge - emphasis on the stifle

American College of Veterinary Surgeons Surgery Summit. Presented at the American College of Veterinary Surgeons Surgery Summit, Portland, OR.

By: L. Schnabel

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Dynamic Provisional Matrix Colloidal-Composite Scaffolds for Partial Anterior Cruciate Ligament Tears

Society for Biomaterials Annual Meeting. Poster presented at the Society for Biomaterials Annual Meeting.

By: G. Scull, J. Thompson, S. Nandi, L. Schnabel, M. Fisher & A. Brown

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Effect of gentamicin on CD3+ T-lymphocyte proliferation and cell viability for treatment of recurrent uveitis in horses: a pilot study

International Equine Ophthalmology Consortium. Presented at the International Equine Ophthalmology Consortium.

By: H. Smith, A. Berglund, L. Schnabel, R. McMullen, B. Gilger & A. Oh

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Effect of serum deprivation on viability and proliferation of equine tenocytes

National Veterinary Scholars Symposium. Poster presented at the National Veterinary Scholars Symposium.

By: A. Souther, D. Koch & L. Schnabel

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Evaluation of Safety and Efficacy of Platelet-like Particles in Trauma Models

Society for Biomaterials Annual Meeting. Poster presented at the Society for Biomaterials Annual Meeting.

By: K. Nellenbach, S. Nandi, E. Mihalko, J. Shetty, D. Koch, M. Erb, L. Lyon, L. Schnabel, T. Barker, A. Brown

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Evaluation of poor performance in the sport horse - axial skeleton

Maryland Delaware Veterinary Medical Association Annual Summer Conference. Presented at the Maryland Delaware Veterinary Medical Association Annual Summer Conference, Ocean City, MD.

By: L. Schnabel

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Fibrin Based Drug Delivery System for Treatment of Staphylococcus Aureus Biofilms

Biomedical Engineering Society Annual Meeting. Presented at the Biomedical Engineering Society Annual Meeting.

By: A. Aligwekwe, G. Scull, A. Valdes Pena, D. Koch, L. Schnabel, J. Pierce, A. Brown

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Fighting Fibrin with Fibrin: Fibrin Based Nanoparticle Incorporation into S. aureus Biofilms

Biomedical Engineering Society Annual Meeting. Presented at the Biomedical Engineering Society Annual Meeting.

By: G. Scull, A. Aligwekwe, D. Koch, K. Nellenbach, J. Solinger, J. Gilbertie, L. Schnabel, A. Brown

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Functional Outcomes After Partial ACL Injury in A Skeletally Immature Porcine Model Differ by Injury Location

Summer Biomechanics, Bioengineering and Biotransport Conference. Presented at the Summer Biomechanics, Bioengineering and Biotransport Conference 2022.

By: D. Howe, J. Thompson, A. Bautista, L. Schnabel, J. Spang & M. Fisher

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Inflammation in Tendon Injury Enhances Mesenchymal Stem Cell Expression of Reparative Genes

ORS Tendon Section Conference. Poster presented at the ORS Tendon Section Conference.

By: D. Koch, A. Berglund, K. Messenger, J. Gilbertie, I. Ellis & L. Schnabel

Source: NC State University Libraries
Added: February 23, 2025

2022 journal article

Interleukin-1β in tendon injury enhances reparative gene and protein expression in mesenchymal stem cells

Frontiers in Veterinary Science, 9.

By: D. Koch n, A. Berglund n, K. Messenger n, J. Gilbertie n, I. Ellis n & L. Schnabel n

author keywords: tendon; cytokine; ultrafiltration probe; mesenchymal stem cell; licensing
topics (OpenAlex): Tendon Structure and Treatment; Wound Healing and Treatments; Diabetic Foot Ulcer Assessment and Management
TL;DR: The defined temporal cytokine microenvironment in a surgically induced model of equine tendon injury and changes in MSC gene and protein expression following in vitro inflammatory licensing with cytokines of similar concentration as identified in vivo support the need to further study the benefit of MSCs administered within the inflamed tendon microenvironment or exogenously licensed with IL-1β in vitro prior to treatment. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: December 12, 2022

2022 conference paper

Interleukin-1 Present in Tendon Injury Enhances the Reparative Function of Mesenchymal Stem Cells

ACVS Surgery Summit. Presented at the ACVS Surgery Summit.

By: D. Koch, A. Berglund, K. Messenger, J. Gilbertie, I. Ellis & L. Schnabel

Source: NC State University Libraries
Added: February 23, 2025

2022 article

Leveraging MRI characterization of longitudinal tears of the deep digital flexor tendon in horses using machine learning

ELKhamary, A. N., Keenihan, E. K., Schnabel, L. V., Redding, W. R., & Schumacher, J. (2022, April 12). VETERINARY RADIOLOGY & ULTRASOUND, Vol. 4.

author keywords: equine; feature extraction; longitudinal tear grading; machine learning classifier; tenoscopy
MeSH headings : Animals; Horse Diseases / diagnosis; Horses; Machine Learning; Magnetic Resonance Imaging / veterinary; Retrospective Studies; Tendons / diagnostic imaging
topics (OpenAlex): Veterinary Equine Medical Research; Tendon Structure and Treatment; Shoulder Injury and Treatment
TL;DR: A systematic approach combining quantitative features with qualitative analyses using ML was diagnostically beneficial in MRI characterization and in discriminating between different grades of LTs of the DDFT of horses. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 25, 2022

2022 journal article

Non‐steroidal anti‐inflammatory drugs in equine orthopaedics

Equine Veterinary Journal, 54(4), 636–648.

By: C. Jacobs n, L. Schnabel n, C. McIlwraith* & A. Blikslager n

author keywords: horse; non-steroidal anti-inflammatory drug; orthopaedics; osteoarthritis
topics (OpenAlex): Veterinary Equine Medical Research; Inflammatory mediators and NSAID effects; Plant Toxicity and Pharmacological Properties
TL;DR: This review aims to summarise the current literature on the use of NSAIDs for equine orthopaedic disorders and examines new and future avenues for the management of inflammation in equine Orthopaedics. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: February 28, 2022

2022 conference paper

Point-of-care-biologics for the treatment of musculoskeletal injuries

Maryland Delaware Veterinary Medical Association Annual Summer Conference. Presented at the Maryland Delaware Veterinary Medical Association Annual Summer Conference, Ocean City, MD.

By: L. Schnabel

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Polyacrylamide Hydrogels (PAAGs) for intra-articular therapy: How they work and how they fit in

2022 Hambletonian CE Seminar. Presented at the 2022 Hambletonian CE Seminar, East Rutherford, NJ.

By: L. Schnabel

Source: NC State University Libraries
Added: February 23, 2025

2022 journal article

Potent Activity of Ertapenem Plus Cefazolin Within Staphylococcal Biofilms: A Contributing Factor in the Treatment of Methicillin-Susceptible <i>Staphylococcus aureus</i> Endocarditis

Open Forum Infectious Diseases, 9(5).

author keywords: cefazolin; ertapenem; endocarditis; Staphylococcus aureus
topics (OpenAlex): Infective Endocarditis Diagnosis and Management; Antimicrobial Resistance in Staphylococcus; Bacterial Identification and Susceptibility Testing
TL;DR: Ertapenem reduces CZ concentrations required to eradicate MSSA biofilms to those achievable in vivo by standard dosing, translating into shorter bacteremia duration in patients with MSSA endocarditis. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: May 10, 2022

2022 conference paper

Principles behind and clinical use of biologic therapies in veterinary medicine

American Association of Equine Veterinary Technicians and Assistants Convention. Presented at the American Association of Equine Veterinary Technicians and Assistants Convention, San Antonio, TX.

By: L. Schnabel

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Rehabilitation and monitoring of tendon and ligament injuries

Maryland Delaware Veterinary Medical Association Annual Summer Conference. Presented at the Maryland Delaware Veterinary Medical Association Annual Summer Conference, Ocean City, MD.

By: L. Schnabel

Source: NC State University Libraries
Added: February 23, 2025

2022 conference paper

Shearing Tenocytes on Direct-write Near-field Electrospun Gelatin Fibers: Towards a Tendon-on-chip

Biomedical Engineering Society Annual Meeting. Poster presented at the Biomedical Engineering Society Annual Meeting.

By: M. Aslam, H. Deal, Z. Davis, D. Koch, J. Daniel, L. Schnabel, M. Daniele, A. Brown, M. Fisher

Source: NC State University Libraries
Added: February 23, 2025

2022 journal article

TGF-β2 enhances expression of equine bone marrow-derived mesenchymal stem cell paracrine factors with known associations to tendon healing

Stem Cell Research & Therapy, 13(1).

By: D. Koch n, L. Schnabel n, I. Ellis n, R. Bates n & A. Berglund n

author keywords: Mesenchymal stem cell; Tenocyte; TGF-beta 2; Equine; Tendon; RNA-sequencing; Paracrine factors; Extracellular matrix
MeSH headings : Animals; Bone Marrow / metabolism; Collagen Type I / metabolism; Cytokines / metabolism; Horses; Mesenchymal Stem Cells / metabolism; Paracrine Communication; RNA / metabolism; Tenascin / genetics; Tenascin / metabolism; Tendons / metabolism; Transforming Growth Factor beta2 / genetics; Transforming Growth Factors / metabolism
topics (OpenAlex): Tendon Structure and Treatment; Wound Healing and Treatments; Periodontal Regeneration and Treatments
TL;DR: Treating equine BM-MSCs with TGF-β2 significantly increases production of paracrine factors and extracellular matrix molecules important for tendon healing and promotes the migration of tenocytes in vitro. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 26, 2022

2022 journal article

TLR-activated mesenchymal stromal cell therapy and antibiotics to treat multi-drug resistant Staphylococcal septic arthritis in an equine model

Annals of Translational Medicine, 10(21), 1157–1157.

By: L. Pezzanite*, L. Chow*, J. Phillips*, G. Griffenhagen*, A. Moore*, T. Schaer*, J. Engiles*, N. Werpy* ...

author keywords: Antibiotic resistance; infectious arthritis; mesenchymal stromal cell (MSC)
topics (OpenAlex): Mesenchymal stem cell research; Wound Healing and Treatments; Orthopedic Infections and Treatments
TL;DR: Combined TLR-activated MSC with antibiotic therapy may be a promising approach to manage joint infections with drug resistant bacteria. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: November 28, 2022

2022 journal article

Tendon sheath masses – What are the differential diagnoses and what diagnostics are needed?

Equine Veterinary Education, 35(2), 74–76.

By: L. Schnabel n, C. Horne n & C. Jacobs n

topics (OpenAlex): Musculoskeletal synovial abnormalities and treatments; Plant and Fungal Interactions Research
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: June 27, 2022

2022 conference paper

Use of stem cells for the treatment of musculoskeletal injuries: what type, how, and when?

Maryland Delaware Veterinary Medical Association Annual Summer Conference. Presented at the Maryland Delaware Veterinary Medical Association Annual Summer Conference, Ocean City, MD.

By: L. Schnabel

Source: NC State University Libraries
Added: February 23, 2025

2021 journal article

Adeno-Associated Virus-Mediated Overexpression of Interleukin-10 Affects the Immunomodulatory Properties of Equine Bone Marrow-Derived Mesenchymal Stem Cells

HUMAN GENE THERAPY, 32(17-18), 907–918.

By: A. Cameron*, K. Even*, R. Linardi*, A. Berglund n, L. Schnabel n, J. Engiles*, K. Ortved*

author keywords: osteoarthritis; PTOA; immunomodulation; mesenchymal stem cell; IL-10; AAV
MeSH headings : Animals; Bone Marrow; Cells, Cultured; Dependovirus / genetics; Horses; Interleukin-10 / genetics; Mesenchymal Stem Cells
topics (OpenAlex): Mesenchymal stem cell research; Osteoarthritis Treatment and Mechanisms; Diabetic Foot Ulcer Assessment and Management
TL;DR: It is hypothesized that BM-MSCs overexpressing IL-10 would have superior immunomodulatory effects leading to increased suppression of T-cell proliferation and decreased production of pro-inflammatory cytokines providing protection of the extra-cellular matrix (ECM) in a stimulated, co-culture OA model. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 24, 2021

2021 journal article

Cross-matching of allogeneic mesenchymal stromal cells eliminates recipient immune targeting

STEM CELLS TRANSLATIONAL MEDICINE, 10(5), 694–710.

By: A. Rowland*, D. Miller*, A. Berglund n, L. Schnabel n, G. Levine*, D. Antczak*, A. Watts*

author keywords: allogeneic; alloimmunization; antibody; autologous; cross&#8208; match; humoral; innate; intra&#8208; articular; major histocompatibility complex (MHC); MSC
MeSH headings : Adaptive Immunity; Allografts; Animals; Chemokine CXCL12; Histocompatibility Testing / veterinary; Horses; Immunity, Innate; Major Histocompatibility Complex; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Synovial Fluid / immunology; Transplantation, Autologous
topics (OpenAlex): Mesenchymal stem cell research; IL-33, ST2, and ILC Pathways; Periodontal Regeneration and Treatments
TL;DR: Until immune recognition of MSCs can be avoided, repeated clinical use of M SCs should be limited to autologous or cross‐matched allogeneic MSC s, and presensitization against donor MHC should be assessed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 11, 2021

2021 article

Effects of continuous passage on the immunomodulator properties of equine bone marrow-derived mesenchymal stem cells in vitro (vol 234, 110203, 2021)

Connard, S. S., Linardi, R. L., Even, K. M., Berglund, A. K., Schnabel, L. V., & Ortved, K. F. (2021, December). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 242.

topics (OpenAlex): Mesenchymal stem cell research
Sources: Web Of Science, NC State University Libraries
Added: March 7, 2022

2021 journal article

Effects of continuous passage on the immunomodulatory properties of equine bone marrow-derived mesenchymal stem cells in vitro

Veterinary Immunology and Immunopathology, 234, 110203.

author keywords: Horse; Mesenchymal stem cells; Continuous passage; Immunomodulation
MeSH headings : Animals; Bone Marrow Cells / drug effects; Bone Marrow Cells / immunology; Bone Marrow Cells / physiology; Cell Differentiation / drug effects; Cell Differentiation / immunology; Cell Proliferation / drug effects; Cells, Cultured; Cytokines / analysis; Cytokines / biosynthesis; Cytokines / immunology; Female; Horses; Immunomodulation; In Vitro Techniques; Interferon-gamma / pharmacology; Lymphocyte Activation / drug effects; Lymphocyte Activation / immunology; Male; Mesenchymal Stem Cells / immunology; Mesenchymal Stem Cells / physiology
topics (OpenAlex): Mesenchymal stem cell research; Wound Healing and Treatments; Tissue Engineering and Regenerative Medicine
TL;DR: It is demonstrated that culture expansion affects some of the immunomodulatory properties of BM-MSCs in vitro, which may suggest that MSCs isolated from a single collection of bone marrow may be culture expanded, but only those from lower passage numbers would be ideal for clinical application. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 12, 2021

2021 journal article

Pathology in Practice

Journal of the American Veterinary Medical Association, 258(9), 961–964.

By: A. DiDomenico n, A. Fowler n, C. Horne n, P. Bizikova n, L. Schnabel n & D. Stowe n

MeSH headings : Animals
topics (OpenAlex): Facial Rejuvenation and Surgery Techniques; Autoimmune and Inflammatory Disorders; Veterinary Oncology Research
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 10, 2021

2021 journal article

TGF-β2 Reduces the Cell-Mediated Immunogenicity of Equine MHC-Mismatched Bone Marrow-Derived Mesenchymal Stem Cells Without Altering Immunomodulatory Properties

Frontiers in Cell and Developmental Biology, 9.

By: A. Berglund n, J. Long n, J. Robertson n & L. Schnabel n

author keywords: mesenchymal stem cell; TGF-&#946; 2; cytotoxicity; immunogenicity; major histocompatibility complex; allogeneic
topics (OpenAlex): Mesenchymal stem cell research; Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications
TL;DR: It is indicated that treating MSCs with TGF-β2 is a promising strategy to reduce the cell-mediated immunogenicity of MHC-mismatched M SCs and facilitate allogeneic MSC therapy. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: March 8, 2021

2021 journal article

The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence

OSTEOARTHRITIS AND CARTILAGE, 29(3), 402–412.

By: M. Copp n, M. Flanders n, R. Gagliardi n, J. Gilbertie n, G. Sessions*, S. Chubinskaya*, R. Loeser*, L. Schnabel n, B. Diekman n

author keywords: SA-beta-gal; DNA damage; Osteoarthritis; Aging; TGF- beta 1; bFGF
MeSH headings : Animals; Ankle Joint; Cartilage, Articular / cytology; Cartilage, Articular / drug effects; Cartilage, Articular / metabolism; Cellular Senescence / drug effects; Cellular Senescence / genetics; Chemokine CCL2 / drug effects; Chemokine CCL2 / genetics; Chondrocytes / drug effects; Chondrocytes / metabolism; Cyclin-Dependent Kinase Inhibitor p16 / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; DNA Damage / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Histones / drug effects; Histones / metabolism; Horses; Humans; In Vitro Techniques; Inflammation / genetics; Insulin-Like Growth Factor Binding Protein 3 / drug effects; Insulin-Like Growth Factor Binding Protein 3 / genetics; Interleukin-6 / genetics; Matrix Metalloproteinase 13 / drug effects; Matrix Metalloproteinase 13 / genetics; Mitogens / pharmacology; Stifle; Transforming Growth Factor beta1 / pharmacology; beta-Galactosidase / drug effects; beta-Galactosidase / metabolism
topics (OpenAlex): Telomeres, Telomerase, and Senescence; Mesenchymal stem cell research; RNA Interference and Gene Delivery
TL;DR: Treatment of cartilage explants with mitogenic stimuli in the context of cellular damage reliably induces high levels of SA-β-gal activity and other senescence markers, which provides a physiologically relevant model system to investigate the mechanisms of senescences induction. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 29, 2021

2020 article proceedings

Allorecognition of Mesenchymal Stem Cells is Dependent on Major Histocompatibility Complex Haplotype

Presented at the Abstracts of the 47th Annual Conference of the Veterinary Orthopedic Society.

By: A. Rowland, G. Levine, L. Schnabel, A. Berglund, D. Antczak, D. Miller, W. Ae

topics (OpenAlex): Mesenchymal stem cell research; MicroRNA in disease regulation; Cancer-related molecular mechanisms research
Sources: Crossref, NC State University Libraries
Added: March 9, 2025

2020 journal article

Front Cover: 5‐Benzylidene‐4‐Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms (ChemBioChem 7/2020)

ChemBioChem, 21(7), 883–883.

By: B. Frohock n, J. Gilbertie n, J. Daiker n, L. Schnabel n & J. Pierce n

topics (OpenAlex):
Source: ORCID
Added: December 15, 2020

2020 journal article

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

NATURE COMMUNICATIONS, 11(1).

By: P. Dinh n, D. Paudel n, H. Brochu n, K. Popowski n, M. Gracieux n, J. Cores n, K. Huang n, M. Hensley n ...

MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Apoptosis / drug effects; Bleomycin / toxicity; Cell Proliferation; Disease Models, Animal; Exosomes / metabolism; Exosomes / transplantation; Humans; Idiopathic Pulmonary Fibrosis / chemically induced; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Idiopathic Pulmonary Fibrosis / therapy; Lung / cytology; Lung / metabolism; Lung Injury / chemically induced; Lung Injury / metabolism; Lung Injury / pathology; Lung Injury / therapy; Mesenchymal Stem Cells / metabolism; Mice; Myofibroblasts / cytology; Proteomics; Silicon Dioxide / toxicity; Spheroids, Cellular / metabolism
topics (OpenAlex): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis; Medical Imaging and Pathology Studies; Extracellular vesicles in disease
TL;DR: It is shown that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 23, 2020

2020 journal article

One Health in Regenerative Medicine: Report on the Second Havemeyer Symposium on Regenerative Medicine in Horses

Regenerative Medicine, 15(6), 1775–1787.

By: L. Fortier*, L. Goodrich*, I. Ribitsch, L. Schnabel n, D. Shepard*, G. Van de Walle*, A. Watts*, R. Whealands Smith

author keywords: animal model; bone marrow concentrate; horse; interleukin-1 receptor antagonist protein; mesenchymal stem cell; platelet rich plasma; stem cell
MeSH headings : Animals; Cell Differentiation; Congresses as Topic; Horse Diseases / therapy; Horses; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / cytology; One Health; Regenerative Medicine
topics (OpenAlex): Mesenchymal stem cell research; Tissue Engineering and Regenerative Medicine; Periodontal Regeneration and Treatments
TL;DR: Findings from a workshop on the development of translational regenerative medicine in the equine field were disseminated and five themes emerged: stem cell characterization and tenogenic differentiation, interactions between mesenchymal stem cells, other cells and the environment, and clinical use of regenerative therapies. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 31, 2020

2020 journal article

Platelet-rich plasma lysate displays antibiofilm properties and restores antimicrobial activity against synovial fluid biofilms in vitro

JOURNAL OF ORTHOPAEDIC RESEARCH, 38(6), 1365–1374.

author keywords: biofilms; equine model; infectious arthritis; platelet-rich plasma; Staphylococcus aureus
MeSH headings : Aminoglycosides / pharmacology; Animals; Anti-Bacterial Agents / pharmacology; Arthritis, Infectious / drug therapy; Biofilms / drug effects; Female; Horses; Male; Molecular Weight; Platelet-Rich Plasma; Synovial Fluid / microbiology
topics (OpenAlex): Periodontal Regeneration and Treatments; Orthopedic Infections and Treatments; Genital Health and Disease
TL;DR: Overall, PRP‐L exhibited synergism with amikacin against aminoglycoside tolerant biofilm aggregates with greater activity against gram‐positive bacteria, which could lead to a decrease in morbidity and mortality associated with infectious arthritis. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 27, 2020

2019 article

5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms

CHEMBIOCHEM, Vol. 12, pp. 933–937.

By: B. Frohock n, J. Gilbertie n, J. Daiker n, L. Schnabel n & J. Pierce n

MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / pharmacology; Benzylidene Compounds / pharmacology; Biofilms / drug effects; Drug Synergism; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Oxazolidinones / pharmacology; Staphylococcus aureus / physiology; Structure-Activity Relationship
topics (OpenAlex): Synthesis and Catalytic Reactions; Click Chemistry and Applications; Chemical Synthesis and Analysis
TL;DR: An expanded set of 5‐benzylidene‐4‐oxazolidinones is reported that is able to inhibit the formation of Staphylococcus aureus biofilms, disperse preformed biofilm, and are able to significantly reduce the bacterial load in a robust collagen‐matrix model of biofilm infection. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 13, 2020

2019 journal article

Effects of acellular equine amniotic allografts on the healing of experimentally induced full-thickness distal limb wounds in horses

VETERINARY SURGERY, 48(8), 1416–1428.

By: A. Fowler n, J. Gilbertie n, V. Watson*, T. Prange n, J. Osborne n & L. Schnabel n

MeSH headings : Allografts; Amnion; Animals; Bandages / veterinary; Granulation Tissue / physiology; Horse Diseases / therapy; Horses / injuries; Prospective Studies; Skin / injuries; Skin / pathology; Wound Healing / physiology; Wounds and Injuries / therapy; Wounds and Injuries / veterinary
topics (OpenAlex): Wound Healing and Treatments; Surgical Sutures and Adhesives; Reconstructive Surgery and Microvascular Techniques
TL;DR: Application of eAM resulted in increased granulation tissue production while maintaining appropriate healing of experimental wounds and is likely most beneficial for substantial wounds in which expedient production of large amounts ofgranulation tissue is desirable. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 26, 2019

2019 journal article

Equine or porcine synovial fluid as a novel ex vivo model for the study of bacterial free-floating biofilms that form in human joint infections

PLOS ONE, 14(8), e0221012.

Ed(s): A. Al-Bakri

MeSH headings : Animals; Arthritis / microbiology; Arthritis / pathology; Biofilms / growth & development; Disease Models, Animal; Horses; Humans; Staphylococcal Infections / microbiology; Staphylococcal Infections / pathology; Staphylococcus aureus / physiology; Swine; Synovial Fluid / microbiology
topics (OpenAlex): Orthopedic Infections and Treatments; Antimicrobial Resistance in Staphylococcus; Orthopaedic implants and arthroplasty
TL;DR: Staphylococcus aureus and other bacterial pathogens adapt the same biofilm aggregate phenotype with significant antimicrobial tolerance in both equine and porcine synovial fluid, analogous to human synovIAL fluid, to identify novel drug targets for treatment of prevention of these difficult to treat infectious diseases. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 30, 2019

2019 journal article

Oral reserpine administration in horses results in low plasma concentrations that alter platelet biology

EQUINE VETERINARY JOURNAL, 51(4), 537–543.

By: J. Gilbertie n, J. Davis*, G. Davidson n, A. McDonald n, J. Schirmer n & L. Schnabel n

author keywords: horse; reserpine; pharmacokinetics; tranquilisation; platelets; hypercoagulability
MeSH headings : Administration, Oral; Adrenergic Uptake Inhibitors / administration & dosage; Adrenergic Uptake Inhibitors / blood; Adrenergic Uptake Inhibitors / pharmacokinetics; Adrenergic Uptake Inhibitors / pharmacology; Animals; Area Under Curve; Blood Platelets / drug effects; Female; Half-Life; Horses / blood; Male; Reserpine / administration & dosage; Reserpine / blood; Reserpine / pharmacokinetics; Reserpine / pharmacology
topics (OpenAlex): Veterinary Equine Medical Research; Pharmacology and Obesity Treatment; Pain Mechanisms and Treatments
TL;DR: Oral reserpine demonstrates low plasma concentrations and a prolonged half-life in horses and is likely due to serotonin release and re-uptake which primes platelets for activation and thromboxane B2 release. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 22, 2019

2019 chapter

Regenerative Medicine

In J. A. Auer & J. A. Stick (Eds.), Equine Surgery (pp. 104–122).

By: L. Schnabel, L. Boone & J. Peroni

Ed(s): J. Auer & J. Stick

topics (OpenAlex): Mesenchymal stem cell research; Tissue Engineering and Regenerative Medicine; Periodontal Regeneration and Treatments
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 11, 2025

2019 journal article

Subconjunctival bone marrow‐derived mesenchymal stem cell therapy as a novel treatment alternative for equine immune‐mediated keratitis: A case series

Veterinary Ophthalmology, 22(5), 674–682.

By: A. Davis n, L. Schnabel n & B. Gilger n

author keywords: bone marrow-derived mesenchymal stem cells; cornea; equine; immune-mediated keratitis; immunomodulating therapy; subconjunctival therapy
MeSH headings : Animals; Female; Horse Diseases / therapy; Horses; Keratitis / therapy; Keratitis / veterinary; Male; Mesenchymal Stem Cell Transplantation / veterinary; Treatment Outcome
topics (OpenAlex): Corneal Surgery and Treatments; Mesenchymal stem cell research; Wound Healing and Treatments
TL;DR: Experimental results demonstrate the safety and potential efficacy of an innovative solution for IMMK and show that bone marrow-derived mesenchymal stem cells have the potential to modulate the immune system by downregulating inflammation. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: September 9, 2019

2019 journal article

The AVMA's definitions of antimicrobial uses for prevention, control, and treatment of disease

Journal of the American Veterinary Medical Association, 254(7), 792–797.

By: D. Smith*, P. Gaunt*, P. Plummer, H. Cervantes*, P. Davies, V. Fajt*, E. Frey*, M. Jay-Russell* ...

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Anti-Infective Agents; Antimicrobial Stewardship; Humans; Veterinarians; World Health Organization
topics (OpenAlex): Animal Behavior and Welfare Studies; Human-Animal Interaction Studies; Zoonotic diseases and public health
TL;DR: Attempts to evaluate the degree of antimicrobial stewardship on the basis of therapeutic intent are misguided and that use of antimicrobials for prevention, control, or treatment of disease may comply with the principles of antim antibiotic stewardship. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 27, 2024

2019 journal article

Ultrasound-Guided Proximolateral Approach for Digital Flexor Tendon Sheath Injection in the Horse: A Cadaver Study

VCOT Open, 02(02), e37–e43.

By: C. Horne n, W. Redding n, H. Ru n & L. Schnabel n

topics (OpenAlex): Veterinary Equine Medical Research; Tendon Structure and Treatment; Shoulder Injury and Treatment
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3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 6, 2025

2018 review

Diagnosis and management of proximal sesamoid bone fractures in the horse

[Review of ]. EQUINE VETERINARY EDUCATION, 30(8), 450–455.

By: L. Schnabel n & W. Redding n

author keywords: horse; proximal sesamoid bone; fracture; arthroscopy
topics (OpenAlex): Veterinary Equine Medical Research; Shoulder Injury and Treatment; Winter Sports Injuries and Performance
TL;DR: Fractures of the proximal sesamoid bones (PSBs) range in severity from simple to complex and comminuted and can be articular or nonarticular and carry a fair to guarded prognosis for return to racing. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Gram-negative multi-drug resistant bacteria influence survival to discharge for horses with septic synovial structures: 206 Cases (2010-2015)

VETERINARY MICROBIOLOGY, 226, 64–73.

By: J. Gilbertie n, L. Schnabel n, D. Stefanovski, D. Kelly, M. Jacob n & T. Schaer

author keywords: Septic synovitis; Infectious arthritis; Equine; Multi-drug resistance (MDR); Fluoroquinolones; Gram-negative bacteria
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Arthritis, Infectious / microbiology; Arthritis, Infectious / veterinary; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae / drug effects; Enterobacteriaceae Infections / mortality; Enterobacteriaceae Infections / veterinary; Gram-Negative Bacteria / drug effects; Gram-Negative Bacterial Infections / mortality; Gram-Negative Bacterial Infections / veterinary; Horse Diseases / microbiology; Horse Diseases / mortality; Horses; Hospitals, Animal; Microbial Sensitivity Tests; Patient Discharge / statistics & numerical data; Pseudomonas aeruginosa / drug effects; Staphylococcus / drug effects; Synovial Fluid / cytology; Synovial Fluid / microbiology; Synovitis / microbiology; Synovitis / veterinary
topics (OpenAlex): Veterinary Equine Medical Research; Bacterial Identification and Susceptibility Testing; Streptococcal Infections and Treatments
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 3, 2018

2018 journal article

Inflammatory licensed equine MSCs are chondroprotective and exhibit enhanced immunomodulation in an inflammatory environment

STEM CELL RESEARCH & THERAPY, 9.

By: J. Cassano*, L. Schnabel n, M. Goodale* & L. Fortier*

author keywords: Mesenchymal stem cells; Immunomodulation; Inflammatory licensing; Licensing; Polarization; Regenerative medicine
MeSH headings : Animals; Cells, Cultured; Chondrocytes / metabolism; Cytokines / genetics; Cytokines / metabolism; Extracellular Matrix Proteins / genetics; Extracellular Matrix Proteins / metabolism; Female; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / metabolism; Histocompatibility Antigens Class II / genetics; Histocompatibility Antigens Class II / metabolism; Horses; Immunomodulation; Macrophages / immunology; Male; Mesenchymal Stem Cells / immunology
topics (OpenAlex): Mesenchymal stem cell research; Immune cells in cancer; Wound Healing and Treatments
TL;DR: In-vitro licensing prior to therapeutic application could result in a more predictable immunomodulatory and reparative response to MSC therapy compared to in-vivo inflammatory licensing by the recipient environment. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Pooled Platelet-Rich Plasma Lysate Therapy Increases Synoviocyte Proliferation and Hyaluronic Acid Production While Protecting Chondrocytes From Synoviocyte-Derived Inflammatory Mediators

FRONTIERS IN VETERINARY SCIENCE, 5.

By: J. Gilbertie n, J. Long n, A. Schubert n, A. Berglund n, T. Schaer* & L. Schnabel n

author keywords: platelet-rich plasma lysate; osteoarthritis; IL-1 beta; LPS; HA; collagen type II; aggrecan; MMP-13
topics (OpenAlex): Periodontal Regeneration and Treatments; Tendon Structure and Treatment; Osteoarthritis Treatment and Mechanisms
TL;DR: The results of this study support continued investigation into the use of pooled PRP-L for the treatment of osteoarthritis and warrant further in-vitro studies to discern the mechanisms of action of PRp-L. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: December 17, 2018

2018 journal article

The immunomodulatory function of equine MSCs is enhanced by priming through an inflammatory microenvironment or TLR3 ligand

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 195, 33–39.

By: J. Cassano*, L. Schnabel n, M. Goodale* & L. Fortier*

author keywords: Mesenchymal stem cells; MSC; Immunomodulation; TLR; Polarization; Regenerative medicine
MeSH headings : Animals; Coculture Techniques / veterinary; Female; Gene Expression Regulation; Horses / immunology; Immunomodulation / immunology; Immunomodulation / physiology; Inflammation / immunology; Inflammation / physiopathology; Inflammation / veterinary; Lymphocytes / immunology; Lymphocytes / physiology; Macrophages / immunology; Macrophages / physiology; Male; Mesenchymal Stem Cells / immunology; Mesenchymal Stem Cells / physiology; T-Lymphocytes / immunology; T-Lymphocytes / physiology; Toll-Like Receptor 3 / physiology
topics (OpenAlex): Mesenchymal stem cell research; Wound Healing and Treatments; Diabetic Foot Ulcer Assessment and Management
TL;DR: The results suggest that MSCs can be activated by a variety of inflammatory stimuli, but the recipient injured tissue bed in chronic injuries may not contain sufficient inflammatory signals to activate MSC immunomodulatory function. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Allogeneic major histocompatibility complex-mismatched equine bone marrow-derived mesenchymal stem cells are targeted for death by cytotoxic anti-major histocompatibility complex antibodies

EQUINE VETERINARY JOURNAL, 49(4), 539–544.

By: A. Berglund n & L. Schnabel n

author keywords: horse; mesenchymal stem cell; allogeneic; major histocompatibility complex-mismatched; antibody response; complement-dependent cytotoxicity
MeSH headings : Animals; Antibodies / immunology; Antibody Formation / immunology; Bone Marrow; Bone Marrow Cells / cytology; Bone Marrow Cells / immunology; Horses; Major Histocompatibility Complex / immunology; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / immunology
topics (OpenAlex): Mesenchymal stem cell research; Xenotransplantation and immune response; Tissue Engineering and Regenerative Medicine
TL;DR: The cytotoxic antibody response induced in recipient horses following injection with donor MHC‐mismatched MSCs is capable of killing donor MSCS in vitro. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Effect of bone marrow-derived mesenchymal stem cells and stem cell supernatant on equine corneal wound healing in vitro

Stem Cell Research & Therapy, 8(1).

By: A. Sherman n, B. Gilger n, A. Berglund n & L. Schnabel n

author keywords: Mesenchymal stem cells; Equine; Corneal wound healing; Corneal stromal cells/fibroblasts; Scratch assay; TGF-beta 1
MeSH headings : Animals; Biomarkers / metabolism; Bone Marrow Cells / cytology; Corneal Injuries / pathology; Corneal Injuries / therapy; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor / metabolism; Female; Flow Cytometry; Horses; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Transforming Growth Factor beta1 / metabolism; Wound Healing
topics (OpenAlex): Mesenchymal stem cell research; Corneal Surgery and Treatments; Periodontal Regeneration and Treatments
TL;DR: The significant decrease in scratch area in equine corneal fibroblast cultures treated with autologous BM-MSCs compared to MSC-Sp or control treatments suggests that BM- MSCs may substantially improve corNEal wound healing in horses. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Effect of needle diameter on the viability of equine bone marrow derived mesenchymal stem cells

Veterinary Surgery, 46(5), 731–737.

By: H. Lang, L. Schnabel, J. Cassano & L. Fortier

topics (OpenAlex): Mesenchymal stem cell research; Diabetic Foot Ulcer Assessment and Management; Wound Healing and Treatments
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UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 11, 2025

2017 journal article

Immunoprivileged no more: measuring the immunogenicity of allogeneic adult mesenchymal stem cells

Stem Cell Research & Therapy, 8(1).

topics (OpenAlex): Mesenchymal stem cell research; Extracellular vesicles in disease; Tissue Engineering and Regenerative Medicine
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 10, 2025

2017 journal article

Transforming Growth Factor-β2 Downregulates Major Histocompatibility Complex (MHC) I and MHC II Surface Expression on Equine Bone Marrow-Derived Mesenchymal Stem Cells Without Altering Other Phenotypic Cell Surface Markers

Frontiers in Veterinary Science, 4.

By: A. Berglund n, M. Fisher n, K. Cameron n, E. Poole n & L. Schnabel n

topics (OpenAlex): Mesenchymal stem cell research; Immunotherapy and Immune Responses; Immune cells in cancer
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 10, 2025

2016 journal article

Navigational ultrasound imaging: A novel imaging tool for aiding interventional therapies of equine musculoskeletal injuries

EQUINE VETERINARY JOURNAL, 48(2), 195–200.

By: M. Lustgarten n, W. Redding n, L. Schnabel n, T. Prange n & G. Seiler n

author keywords: horse; navigational ultrasound imaging; fusion imaging; musculoskeletal; MRI
MeSH headings : Animals; Forelimb; Hindlimb; Horse Diseases / diagnosis; Horse Diseases / diagnostic imaging; Horse Diseases / surgery; Horses; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging / veterinary; Musculoskeletal Diseases / diagnostic imaging; Musculoskeletal Diseases / pathology; Musculoskeletal Diseases / surgery; Musculoskeletal Diseases / veterinary; Tomography, X-Ray Computed / veterinary; Ultrasonography
topics (OpenAlex): Veterinary Equine Medical Research; Tendon Structure and Treatment; Ultrasound Imaging and Elastography
TL;DR: Navigational ultrasound imaging is a complementary imaging modality that can be used for the treatment of equine soft tissue musculoskeletal injuries diagnosed with MRI and is considered successful based on the authors' criteria. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Transnasal, Endoscopically Guided Skull‐Based Surgery by Pharyngotomy for Mass Removal from the Sphenopalatine Sinus in a Horse

Veterinary Surgery, 45(8), 1108–1117.

By: R. Radcliffe, Y. Messiaen, N. Irby, T. Divers, C. Dewey, K. Mitchell, L. Schnabel, A. Bezuidenhout, P. Scrivani, N. Ducharme

Sources: Crossref, NC State University Libraries
Added: March 10, 2025

2015 journal article

Equine allogeneic bone marrow-derived mesenchymal stromal cells elicit antibody responses in vivo

STEM CELL RESEARCH & THERAPY, 6.

MeSH headings : Animals; Antibodies / immunology; Antibody Formation / immunology; Bone Marrow Cells / cytology; Bone Marrow Cells / immunology; Female; Horses; Inflammation / immunology; Major Histocompatibility Complex / immunology; Male; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / immunology; Transplantation, Homologous / methods
topics (OpenAlex): Mesenchymal stem cell research; Tissue Engineering and Regenerative Medicine; Cancer Cells and Metastasis
TL;DR: Four recipient horses had high-titered anti-ELA-A2 antibody responses resulting in greater than 80% donor PBL death in the microcytotoxicity assays and one of these horses also developed antibodies that cross-reacted when tested on lymphocyte targets from a horse with an unrelated MHC type. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Mesenchymal Stem Cell Therapy: Clinical Progress and Opportunities for Advancement

Current Pathobiology Reports, 3(1), 1–7.

By: J. Cassano*, L. Schnabel n, A. Betancourt*, D. Antczak* & L. Fortier*

topics (OpenAlex): Mesenchymal stem cell research; Electrospun Nanofibers in Biomedical Applications; Tissue Engineering and Regenerative Medicine
TL;DR: A polarization paradigm where different priming stimuli, reflective of an injured tissue, induce either a pro-inflammatory or immunosuppressive MSC phenotype, provides the potential for manipulating MSCs to obtain more predictable clinical effects. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2014 journal article

Equine bone marrow-derived mesenchymal stromal cells are heterogeneous in MHC class II expression and capable of inciting an immune response in vitro

STEM CELL RESEARCH & THERAPY, 5.

By: L. Schnabel n, L. Pezzanite*, D. Antczak*, M. Felippe* & L. Fortier*

MeSH headings : Animals; Cells, Cultured; Genes, MHC Class II / genetics; Genes, MHC Class II / immunology; Horses; Immunophenotyping; Interferon-gamma / pharmacology; Leukocytes / immunology; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / immunology
topics (OpenAlex): Mesenchymal stem cell research; Cancer Cells and Metastasis; Tissue Engineering and Regenerative Medicine
TL;DR: MSCs should be confirmed as MHC class II negative before allogeneic application, and it must be considered that even M HC class II-negative MSCs could upregulate MHCclass II expression if implanted into an area of active inflammation, as demonstrated with in vitro stimulation with IFN-γ. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Induced pluripotent stem cells have similar immunogenic and more potent immunomodulatory properties compared with bone marrow-derived stromal cells in vitro

REGENERATIVE MEDICINE, 9(5), 621–635.

By: L. Schnabel n, C. Abratte*, J. Schimenti*, M. Felippe*, J. Cassano*, T. Southard*, J. Cross*, L. Fortier*

author keywords: allogeneic stem cell therapy; immunogenicity; immunomodulatory; induced pluripotent stem cell; mesenchymal stromal cell; transplantation medicine
MeSH headings : Animals; Cell Culture Techniques; Cell Differentiation; Cytokines / metabolism; Female; Immunomodulation; Induced Pluripotent Stem Cells / immunology; Male; Mesenchymal Stem Cells / immunology; Mice; Mice, Inbred C57BL
topics (OpenAlex): Mesenchymal stem cell research; Pluripotent Stem Cells Research; Biomedical Ethics and Regulation
TL;DR: These results provide important information when considering the use of iPSCs in place of MSCs in both regenerative and transplantation medicine. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Laparoscopic‐Guided Compared to Skilled Instructor Support for Student Rectal Examination Training Using Live Horses in the Veterinary Curriculum

Veterinary Surgery, 44(3), 352–358.

By: R. Radcliffe, A. Manchester, H. Mohammed, K. Ortved, H. Reesink, L. Schnabel, H. Lang, P. Scrivani, S. Fubini

Sources: Crossref, NC State University Libraries
Added: March 10, 2025

2014 chapter

Mixed Methods and Triangulation of Evidence

In K. M. Williams (Ed.), Doing Research to Improve Teaching and Learning (pp. 100–122).

By: L. Schnabel

Ed(s): K. Williams

Sources: Crossref, NC State University Libraries
Added: March 11, 2025

2013 conference paper

Equine bone marrow-derived mesenchymal stem cells are heterogeneous in MHC Class II expression and capable of inciting an immune response in vitro

NCSU/UNC Regenerative Medicine Symposium. Presented at the NCSU/UNC Regenerative Medicine Symposium.

By: L. Schnabel, L. Pezzanite, D. Antczak & L. Fortier

Source: NC State University Libraries
Added: February 16, 2025

2013 journal article

Increasing Platelet Concentrations in Leukocyte-Reduced Platelet-Rich Plasma Decrease Collagen Gene Synthesis in Tendons

The American Journal of Sports Medicine, 42(1), 42–49.

By: S. Boswell*, L. Schnabel*, H. Mohammed*, E. Sundman*, T. Minas* & L. Fortier*

topics (OpenAlex): Periodontal Regeneration and Treatments; Tendon Structure and Treatment; Platelet Disorders and Treatments
Sources: Crossref, NC State University Libraries
Added: March 11, 2025

2013 journal article

Plasma and synovial fluid concentration of doxycycline following low‐dose, low‐frequency administration, and resultant inhibition of matrix metalloproteinase‐13 from interleukin‐stimulated equine synoviocytes

Equine Veterinary Journal, 46(2), 198–202.

By: M. Maher*, L. Schnabel*, J. Cross*, M. Papich n, T. Divers* & L. Fortier*

author keywords: synovial fluid; osteoarthritis; doxycycline; horse; MMP
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Cells, Cultured; Cross-Over Studies; Dose-Response Relationship, Drug; Doxycycline / administration & dosage; Doxycycline / blood; Doxycycline / chemistry; Doxycycline / pharmacokinetics; Drug Administration Schedule; Gene Expression Regulation, Enzymologic / drug effects; Horses; Matrix Metalloproteinase 13 / genetics; Matrix Metalloproteinase 13 / metabolism; Matrix Metalloproteinase Inhibitors / administration & dosage; Matrix Metalloproteinase Inhibitors / blood; Matrix Metalloproteinase Inhibitors / chemistry; Matrix Metalloproteinase Inhibitors / pharmacokinetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Synovial Fluid / chemistry; Synovial Membrane / cytology
topics (OpenAlex): Veterinary Equine Medical Research; Tendon Structure and Treatment; Osteoarthritis Treatment and Mechanisms
TL;DR: This study supports the use of doxycycline as a disease modifying osteoarthritic drug and achieves SF concentrations in vivo capable of diminishing MMP-13 expression. (via Semantic Scholar)
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Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2013 journal article

Therapeutic use of stem cells in horses: Which type, how, and when?

The Veterinary Journal, 197(3), 570–577.

By: L. Schnabel*, L. Fortier*, C. Wayne McIlwraith* & K. Nobert

author keywords: Stem cells; Equine musculoskeletal disorders; Tendonitis; Osteoarthritis; FDA
MeSH headings : Animals; Horse Diseases / therapy; Horses; Stem Cell Transplantation / veterinary
topics (OpenAlex): Mesenchymal stem cell research; Tissue Engineering and Regenerative Medicine; Xenotransplantation and immune response
TL;DR: Clinicians must be aware of the limitation in current knowledge regarding stem cells, and the impending regulatory laws that may limit the use of equine stem cells in clinical patients. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2013 journal article

Use of a Formal Assessment Instrument for Evaluation of Veterinary Student Surgical Skills

Veterinary Surgery, 42(4), 488–496.

By: L. Schnabel, P. Maza, K. Williams, N. Irby, C. McDaniel & B. Collins

Sources: Crossref, NC State University Libraries
Added: March 11, 2025

2012 journal article

Cell- and gene-based approaches to tendon regeneration

Journal of Shoulder and Elbow Surgery, 21(2), 278–294.

By: A. Nixon*, A. Watts* & L. Schnabel*

author keywords: Tendon; rotator cuff; shoulder; MSC; stem cells; gene therapy; regeneration
MeSH headings : Animals; Forecasting; Genetic Therapy / methods; Genetic Therapy / trends; Humans; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cell Transplantation / trends; Recovery of Function; Regeneration / physiology; Rotator Cuff Injuries; Tendon Injuries / therapy; Tendons / physiology; Tensile Strength; Treatment Outcome; Wound Healing / physiology
topics (OpenAlex): Tendon Structure and Treatment; Shoulder Injury and Treatment; Knee injuries and reconstruction techniques
TL;DR: Cell- and gene-enhanced cell research for tendon repair is summarized and future directions for rotator cuff repair using biologic composites are provided. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2012 journal article

Comparison of Three Methods to Quantify Repair Cartilage Collagen Orientation

CARTILAGE, 4(2), 111–120.

By: K. Ross, R. Williams, L. Schnabel, H. Mohammed, H. Potter, G. Bradica, E. Castiglione, S. Pownder ...

Sources: Crossref, NC State University Libraries
Added: March 10, 2025

2012 journal article

Genetic background affects induced pluripotent stem cell generation

Stem Cell Research & Therapy, 3(4).

By: L. Schnabel*, C. Abratte*, J. Schimenti*, T. Southard* & L. Fortier*

topics (OpenAlex): Pluripotent Stem Cells Research; CRISPR and Genetic Engineering; Renal and related cancers
Sources: Crossref, NC State University Libraries
Added: March 11, 2025

2011 journal article

Pharmacokinetics and distribution of minocycline in mature horses after oral administration of multiple doses and comparison with minimum inhibitory concentrations

Equine Veterinary Journal, 44(4), 453–458.

By: L. Schnabel*, M. Papich n, T. Divers*, C. Altier*, M. Aprea*, T. McCARREL*, L. Fortier*

author keywords: horse; minocycline; pharmacokinetics; synovial fluid; cerebral spinal fluid; aqueous humour; minimum inhibitory concentrations
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Aqueous Humor / chemistry; Area Under Curve; Bacteria / drug effects; Drug Administration Schedule; Female; Half-Life; Horses / blood; Horses / cerebrospinal fluid; Horses / metabolism; Male; Microbial Sensitivity Tests; Minocycline / administration & dosage; Minocycline / chemistry; Minocycline / pharmacokinetics; Pilot Projects; Synovial Fluid / chemistry; Tissue Distribution
topics (OpenAlex): Ocular Infections and Treatments; Aquaculture disease management and microbiota; Bacterial Identification and Susceptibility Testing
TL;DR: The use of orally administered minocycline at a dose of 4 mg/kg bwt every 12 h for the treatment of nonocular infections caused by susceptible (MIC ≤ 0.25 µg/ml) organisms in horses is supported. (via Semantic Scholar)
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Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2010 journal article

Concentrated Bone Marrow Aspirate Improves Full-Thickness Cartilage Repair Compared with Microfracture in the Equine Model

The Journal of Bone and Joint Surgery-American Volume, 92(10), 1927–1937.

By: L. Fortier, H. Potter, E. Rickey, L. Schnabel, L. Foo, L. Chong, T. Stokol, J. Cheetham, A. Nixon

Sources: Crossref, NC State University Libraries
Added: March 11, 2025

2010 journal article

IMAGING DIAGNOSIS—EQUINE NASAL SEPTAL THICKENING DUE TO CHRONIC CHONDRITIS

Veterinary Radiology & Ultrasound, 51(1), 65–68.

By: A. Sharma, M. Thompson, L. Schnabel, A. Mete & R. Hackett

Sources: Crossref, NC State University Libraries
Added: March 10, 2025

2010 journal article

Orally administered doxycycline accumulates in synovial fluid compared to plasma

Equine Veterinary Journal, 42(3), 208–212.

By: L. Schnabel n, M. Papich n, A. Watts n & L. Fortier

author keywords: horse; doxycycline; osteoarthritis; synovial fluid; MMP
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Dose-Response Relationship, Drug; Doxycycline / administration & dosage; Doxycycline / analysis; Doxycycline / blood; Doxycycline / pharmacokinetics; Half-Life; Horses; Synovial Fluid / chemistry
topics (OpenAlex): Rheumatoid Arthritis Research and Therapies; Inflammatory mediators and NSAID effects; Osteoarthritis Treatment and Mechanisms
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2010 journal article

Racing performance after arthroscopic removal of apical sesamoid fracture fragments in Thoroughbred horses age ≥ 2 years: 84 cases (1989-2002)

Equine Veterinary Journal, 38(5), 446–451.

By: L. Schnabel, L. Bramlage, H. Mohammed, R. Embertson, A. Ruggles & S. Hopper

topics (OpenAlex): Veterinary Equine Medical Research; Winter Sports Injuries and Performance; Shoulder Injury and Treatment
Sources: Crossref, NC State University Libraries
Added: March 11, 2025

2010 journal article

Size and geometry of apical sesamoid fracture fragments as a determinant of prognosis in Thoroughbred racehorses

Equine Veterinary Journal, 43(4), 412–417.

By: J. Kamm, L. Bramlage, L. Schnabel, A. Ruggles, R. Embertson & S. Hopper

topics (OpenAlex): Veterinary Equine Medical Research; Ruminant Nutrition and Digestive Physiology; Reproductive Physiology in Livestock
Sources: Crossref, NC State University Libraries
Added: March 10, 2025

2009 journal article

Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons

Journal of Orthopaedic Research, 27(10), 1392–1398.

By: L. Schnabel*, M. Lynch*, M. van der Meulen*, A. Yeager*, M. Kornatowski* & A. Nixon*

author keywords: mesenchymal stem cells; IGF-I; gene therapy; tendinitis; in vivo
MeSH headings : ADAM Proteins / metabolism; ADAMTS4 Protein; Animals; Biomechanical Phenomena; Cell- and Tissue-Based Therapy / methods; Cell- and Tissue-Based Therapy / veterinary; Collagen Type I / metabolism; Collagen Type III / metabolism; Extracellular Matrix Proteins / metabolism; Female; Genetic Therapy / methods; Genetic Therapy / veterinary; Glycoproteins / metabolism; Horse Diseases / metabolism; Horse Diseases / pathology; Horse Diseases / therapy; Horses; Insulin-Like Growth Factor I / genetics; Insulin-Like Growth Factor I / metabolism; Male; Matrilin Proteins; Matrix Metalloproteinase 13 / metabolism; Matrix Metalloproteinase 3 / metabolism; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cell Transplantation / veterinary; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Procollagen N-Endopeptidase / metabolism; Tendinopathy / metabolism; Tendinopathy / therapy; Tendinopathy / veterinary; Tendons / diagnostic imaging; Tendons / metabolism; Tendons / pathology; Ultrasonography
topics (OpenAlex): Tendon Structure and Treatment; Shoulder Injury and Treatment; Sports injuries and prevention
TL;DR: A benefit to the use of MSCs and AdIGF‐MSCs for the treatment of tendinitis is indicated, following previous work that demonstrated the value of insulin‐like growth factor‐I to stimulate cellular proliferation and tendon fiber deposition in the core lesion of Tendinitis. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 29, 2020

2009 journal article

Trochlear Block Recession in an Alpaca with Traumatic Lateral Patellar Luxation

Veterinary Surgery, 38(3), 421–425.

By: S. Furman, L. Fortier, L. Schnabel & U. Krotscheck

Sources: Crossref, NC State University Libraries
Added: March 10, 2025

2008 journal article

Effects of platelet rich plasma and acellular bone marrow on gene expression patterns and DNA content of equine suspensory ligament explant cultures

Equine Veterinary Journal, 40(3), 260–265.

By: L. Schnabel, H. Mohammed, M. Jacobson & L. Fortier

Sources: Crossref, NC State University Libraries
Added: March 10, 2025

2007 journal article

Assessment of cartilage degradation effects of matrix metalloproteinase-13 in equine cartilage cocultured with synoviocytes

American Journal of Veterinary Research, 68(4), 379–384.

By: L. Fortier, L. Schnabel, H. Mohammed & K. Mayr

topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Protease and Inhibitor Mechanisms; Cell Adhesion Molecules Research
Sources: Crossref, NC State University Libraries
Added: March 10, 2025

2007 journal article

Gene Therapy in Musculoskeletal Repair

Annals of the New York Academy of Sciences, 1117(1), 310–327.

By: A. Nixon, L. Goodrich, M. Scimeca, T. Witte, L. Schnabel, A. Watts, P. Robbins

Sources: Crossref, NC State University Libraries
Added: March 10, 2025

2007 journal article

Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons

Journal of Orthopaedic Research, 25(2), 230–240.

By: L. Schnabel*, H. Mohammed*, B. Miller*, W. McDermott*, M. Jacobson*, K. Santangelo*, L. Fortier*

author keywords: platelet rich plasma (PRP); tendonitis; collagen; cartilage oligomeric matrix protein (COMP); matrix metalloproteinase (MMP)
MeSH headings : Animals; Becaplermin; Collagen / genetics; Collagen / metabolism; DNA / genetics; DNA / metabolism; Dose-Response Relationship, Drug; Extracellular Matrix Proteins / genetics; Extracellular Matrix Proteins / metabolism; Gene Expression Regulation / physiology; Glycoproteins / genetics; Glycoproteins / metabolism; Horses; Insulin-Like Growth Factor I / genetics; Insulin-Like Growth Factor I / metabolism; Matrilin Proteins; Metabolism / genetics; Metabolism / physiology; Platelet-Derived Growth Factor / genetics; Platelet-Derived Growth Factor / metabolism; Platelet-Rich Plasma / physiology; Proto-Oncogene Proteins c-sis; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tendinopathy / drug therapy; Tendons / metabolism; Tissue Culture Techniques; Transforming Growth Factor beta1 / genetics; Transforming Growth Factor beta1 / metabolism
topics (OpenAlex): Tendon Structure and Treatment; Periodontal Regeneration and Treatments; Shoulder Injury and Treatment
TL;DR: The findings of this study support in vivo investigation of PRP as an autogenous, patient‐side treatment for tendonitis as well as other blood products tested. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2007 journal article

Racing performance after arthroscopic removal of apical sesamoid fracture fragments in Thoroughbred horses age <2 years: 151 cases (1989–2002)

Equine Veterinary Journal, 39(1), 64–68.

By: L. Schnabel, L. Bramlage, H. Mohammed, R. Embertson, A. Ruggles & S. Hopper

topics (OpenAlex): Veterinary Equine Medical Research; Shoulder Injury and Treatment
Sources: Crossref, NC State University Libraries
Added: March 11, 2025

Employment

Updated: June 4th, 2024 13:20

2013 - present

North Carolina State University Raleigh, NC, US
Professor Equine Orthopedic Surgery Clinical Sciences

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