Leonard Williams

Works (4)

Updated: April 5th, 2024 10:57

2020 article

3D Imaging and metabolomic profiling reveal higher neuroactive kavalactone contents in lateral roots and crown root peels of Piper methysticum (kava)

Jaiswal, Y. S., Yerke, A. M., Bagley, M. C., Ekelöf, M., Weber, D., Haddad, D., … Williams, L. L. (2020, September 1). GigaScience, Vol. 9.

By: Y. Jaiswal *, A. Yerke *, M. Bagley n, M. Ekelöf n, D. Weber *, D. Haddad *, A. Fodor *, D. Muddiman n , L. Williams*

author keywords: kava; kavalactones; metabolomics; 3D imaging; mass spectrometry imaging
MeSH headings : Imaging, Three-Dimensional; Kava; Lactones; Metabolomics; X-Ray Microtomography
topics (OpenAlex): Medicinal Plant Extracts Effects; Alkaloids: synthesis and pharmacology; Phytochemistry and Biological Activities
TL;DR: Detailed metabolomic profile and spatio-temporal characteristics of tissues from the roots and stems are characterized using cross-platform metabolomics and a 3D imaging approach to provide mechanistic insights into the social and clinical practice of the use of only peeled roots. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: November 16, 2020

2019 article

A substitute variety for agronomically and medicinally important Serenoa repens (saw palmetto)

Jaiswal, Y., Weber, D., Yerke, A., Xue, Y., Lehman, D., Williams, T., … Williams, L. (2019, March 18). Scientific Reports, Vol. 3.

By: Y. Jaiswal *, D. Weber *, A. Yerke *, Y. Xue*, D. Lehman n, T. Williams n , T. Xiao*, D. Haddad *, L. Williams*

Contributors: Y. Jaiswal *, D. Weber *, A. Yerke *, Y. Xue*, D. Lehman n, T. Williams n , T. Xiao*, D. Haddad *, L. Williams*

MeSH headings : Conservation of Natural Resources; Fruit / anatomy & histology; Fruit / chemistry; Fruit / metabolism; Humans; Lipid Metabolism; Lipids / analysis; Male; Metabolomics; Phytotherapy / methods; Plant Extracts / therapeutic use; Plants, Medicinal / anatomy & histology; Plants, Medicinal / chemistry; Plants, Medicinal / metabolism; Prostatic Hyperplasia / drug therapy; Secondary Metabolism; Serenoa / chemistry; Serenoa / metabolism; Spatial Analysis; Water / analysis; Water / metabolism
topics (OpenAlex): Plant Water Relations and Carbon Dynamics; Biocrusts and Microbial Ecology; Mass Spectrometry Techniques and Applications
TL;DR: The first study, to propose the use of the S. repens forma glauca (silver variety) as a qualitative substitute for the wild variety, to support its conservation and provide a new strategy for studying phenotypic traits and metabolite synthesis of closely related plant varieties. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 2, 2019

2019 article

Peanut protein-polyphenol aggregate complexation suppresses allergic sensitization to peanut by reducing peanut-specific IgE in C3H/HeJ mice

Bansode, R. R., Randolph, P. D., Plundrich, N. J., Lila, M. A., & Williams, L. L. (2019, June 17). Food Chemistry, Vol. 299.

By: R. Bansode*, P. Randolph*, N. Plundrich n, M. Lila n  & L. Williams*

author keywords: Peanut allergy; IgE; CD63; Polyphenol; Blueberry; Cranberry
MeSH headings : Animals; Arachis / chemistry; Arachis / immunology; Female; Immunoglobulin E / immunology; Mice; Mice, Inbred C3H; Peanut Hypersensitivity / prevention & control; Plant Proteins / chemistry; Plant Proteins / immunology; Polyphenols / chemistry; Species Specificity
topics (OpenAlex): Food Allergy and Anaphylaxis Research; Allergic Rhinitis and Sensitization; Contact Dermatitis and Allergies
TL;DR: It is demonstrated for the first time that complexation of polyphenols to peanut flour can potentially lower plasma IgE of peanut-sensitized C3H/HeJ mice. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019

2018 article

Peanut flour aggregation with polyphenolic extracts derived from peanut skin inhibits IgE binding capacity and attenuates RBL-2H3 cells degranulation via MAPK signaling pathway

Bansode, R. R., Plundrich, N. J., Randolph, P. D., Lila, M. A., & Williams, L. L. (2018, May 3). Food Chemistry, Vol. 263, pp. 307–314.

By: R. Bansode*, N. Plundrich  n, P. Randolph*, M. Lila n  & L. Williams*

author keywords: Peanut skin; Peanut flour; Peanut allergy; Degranulation; Polyphenols; RBL-2H3 cells
MeSH headings : Allergens / immunology; Allergens / metabolism; Animals; Arachis / chemistry; Arachis / metabolism; Basophils / cytology; Basophils / drug effects; Basophils / metabolism; Cell Degranulation / drug effects; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Histamine / metabolism; Immunoglobulin E / analysis; Immunoglobulin E / immunology; MAP Kinase Signaling System / drug effects; Plant Proteins / immunology; Plant Proteins / metabolism; Polyphenols / chemistry; Polyphenols / pharmacology; Rats
topics (OpenAlex): Food Allergy and Anaphylaxis Research; Allergic Rhinitis and Sensitization; Eosinophilic Esophagitis
TL;DR: Results show that aggregation of PSP to PN proteins reduces allergic response by inhibiting Ca2+-induced MAPK-dependent cell degranulation. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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