Mary Anna Carbone

Works (43)

Updated: February 19th, 2026 17:09

2025 article

Effects of aging on gene expression networks in the Drosophila genetic reference panel

Tan, S., Carbone, M. A., Zhou, S., Morozova, T., Arya, G., Zhang, F., … Mackay, T. F. C. (2025, July 1). Cell Reports, Vol. 44.

By: S. Tan *, M. Carbone n , S. Zhou n, T. Morozova n, G. Arya n, F. Zhang *, R. Anholt*, W. Huang, T. Mackay*

MeSH headings : Animals; Aging / genetics; Gene Regulatory Networks; Male; Female; Quantitative Trait Loci / genetics; Longevity / genetics; Transcriptome / genetics; Drosophila melanogaster / genetics; Phenotype; Gene Expression Profiling
topics (OpenAlex): Genetics, Aging, and Longevity in Model Organisms; Genetic Mapping and Diversity in Plants and Animals; Genetic and phenotypic traits in livestock
Sources: Web Of Science, NC State University Libraries
Added: August 4, 2025

2025 article

Systems genetics of lifespan and senescence in Drosophila melanogaster

Aghdam, M. N., Unselt, D., Adonay, M. E., Morozova, T. V., Carbone, M. A., Arya, G. H., … Mackay, T. F. C. (2025, December 7). BMC Biology.

By: M. Aghdam *, D. Unselt  n, M. Adonay*, T. Morozova n, M. Carbone n , G. Arya n, L. Turlapati n, V. Shankar *, R. Anholt n, T. Mackay*

MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Longevity / genetics; Female; Male; Aging / genetics; Quantitative Trait Loci
topics (OpenAlex): Genetics, Aging, and Longevity in Model Organisms; Developmental Biology and Gene Regulation; Physiological and biochemical adaptations
Sources: NC State University Libraries, NC State University Libraries
Added: December 9, 2025

2024 article

The genetic basis of incipient sexual isolation in Drosophila melanogaster

Yamamoto, A., Huang, W., Carbone, M. A., Anholt, R. R. H., & Mackay, T. F. C. (2024, July 24). Proceedings of the Royal Society B Biological Sciences, Vol. 291.

By: A. Yamamoto n, W. Huang n, M. Carbone n , R. Anholt n & T. Mackay n

author keywords: speciation; genome-wide association study; mating behaviour; Drosophila genetic reference panel
MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Male; Female; Reproductive Isolation; Zimbabwe; Genetic Speciation; Genetic Variation; Sexual Behavior, Animal; Sex Attractants
topics (OpenAlex): Genetic diversity and population structure; Plant and animal studies; Animal Behavior and Reproduction
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15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 5, 2024

2022 article

Asymmetrical lineage introgression and recombination in populations of Aspergillus flavus : implications for biological control

Molo, M. S., White, J. B., Cornish, V., Gell, R. M., Baars, O., Singh, R., … Carbone, I. (2022, March 14). (Vol. 3). Vol. 3.

By: M. Molo n, J. White  n, V. Cornish n , R. Gell n, O. Baars n , R. Singh n, M. Carbone n , T. Isakeit * ...

topics (OpenAlex): Mycotoxins in Agriculture and Food; Plant Pathogens and Fungal Diseases; Plant Disease Resistance and Genetics
TL;DR: It is reported that the two distinct A. flavus evolutionary lineages IB and IC differ significantly in their frequency distributions across states, and there is evidence of increased unidirectional gene flow from lineage IB into IC, inferred to be due to the applied Afla-Guard biocontrol strain. (via Semantic Scholar)
Source: ORCID
Added: March 15, 2022

2022 article

Asymmetrical lineage introgression and recombination in populations of Aspergillus flavus: Implications for biological control

Molo, M. S., White, J. B., Cornish, V., Gell, R. M., Baars, O., Singh, R., … Carbone, I. (2022, October 27). (W. C. Nierman, Ed.). PLoS ONE, Vol. 17.

By: M. Molo n, J. White n, V. Cornish n , R. Gell n, O. Baars n , R. Singh n, M. Carbone n , T. Isakeit * ...

Ed(s): W. Nierman

MeSH headings : Aspergillus flavus / genetics; Aflatoxins / genetics; Biological Control Agents; Zea mays / genetics; Zea mays / microbiology; Recombination, Genetic
topics (OpenAlex): Mycotoxins in Agriculture and Food; Plant Pathogens and Fungal Diseases; Plant Disease Resistance and Genetics
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 28, 2022

2021 article

Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster

Baker, B. M., Carbone, M. A., Huang, W., Anholt, R. R. H., & Mackay, T. F. C. (2021, May 31). Proceedings of the National Academy of Sciences, Vol. 118.

By: B. Baker*, M. Carbone n , W. Huang*, R. Anholt* & T. Mackay*

author keywords: extreme QTL genome-wide association mapping; Drosophila Genetic Reference Panel; RNA interference; advanced intercross population
MeSH headings : Animals; Cocaine / pharmacology; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster; Epistasis, Genetic; Female; Genome-Wide Association Study; Humans; Male; Methamphetamine / pharmacology; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Sex Characteristics
topics (OpenAlex): Neurobiology and Insect Physiology Research; Physiological and biochemical adaptations; Genetics, Aging, and Longevity in Model Organisms
TL;DR: It is shown that the genetic architecture underlying variation in voluntary cocaine and methamphetamine consumption differs between sexes and is dominated by variants in genes associated with connectivity and function of the nervous system. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 23, 2021

2020 article

Gene expression networks in the Drosophila Genetic Reference Panel

Everett, L. J., Huang, W., Zhou, S., Carbone, M. A., Lyman, R. F., Arya, G. H., … Mackay, T. F. C. (2020, March 1). Genome Research, Vol. 30, pp. 485–496.

By: L. Everett n, W. Huang n, S. Zhou n, M. Carbone n , R. Lyman n, G. Arya n, M. Geisz n, J. Ma * ...

MeSH headings : Animals; DNA Transposable Elements; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Drosophila melanogaster / microbiology; Female; Gene Expression Regulation; Gene Regulatory Networks; Genetic Variation; High-Throughput Nucleotide Sequencing; Male; Microbiota / genetics; Quantitative Trait Loci; Sequence Analysis, RNA
topics (OpenAlex): Genomics and Phylogenetic Studies; Genetic diversity and population structure; RNA Research and Splicing
TL;DR: This study performed deep RNA sequencing of 200 Drosophila Genetic Reference Panel inbred lines with complete genome sequences and mapped expression quantitative trait loci for annotated genes, novel transcribed regions, transposable elements and microbial species, providing new insights regarding the role of natural genetic variation in regulating gene expression. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 14, 2020

2020 article

Genotype by environment interaction for gene expression in Drosophila melanogaster

Huang, W., Carbone, M. A., Lyman, R. F., Anholt, R. R. H., & Mackay, T. F. C. (2020, October 28). Nature Communications, Vol. 11.

By: W. Huang n, M. Carbone n , R. Lyman n, R. Anholt n & T. Mackay n

MeSH headings : Animals; Drosophila melanogaster / genetics; Female; Gene Expression; Gene Expression Regulation; Gene Regulatory Networks; Gene-Environment Interaction; Genes, Insect; Genetic Variation; Genotype; Male; Quantitative Trait Loci; RNA-Seq; Temperature; Transcriptome
topics (OpenAlex): Genetic Mapping and Diversity in Plants and Animals; Evolution and Genetic Dynamics; Bioinformatics and Genomic Networks
TL;DR: It is shown that developing under different temperatures changes the genetic architecture of regulatory variation in Drosophila melanogaster gene expression yet the co- expression network remains robust, and data suggest that stabilizing selection on gene expression may promote co-expression network robustness. (via Semantic Scholar)
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13. Climate Action (Web of Science)
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 30, 2020

2020 article

Heat shock proteins and small nucleolar RNAs are dysregulated in a Drosophila model for feline hypertrophic cardiomyopathy

Tallo, C. A., Duncan, L. H., Yamamoto, A. H., Slaydon, J. D., Arya, G. H., Turlapati, L., … Carbone, M. A. (2020, November 27). (M. Arbeitman, Ed.). G3 Genes Genomes Genetics, Vol. 11, pp. 1–16.

By: C. Tallo n, L. Duncan n, A. Yamamoto n, J. Slaydon n, G. Arya n, L. Turlapati n, T. Mackay*, M. Carbone n 

Ed(s): M. Arbeitman

author keywords: MYBPC3; cMyBP-C; Drosophila melanogaster; feline HCM; hypertrophic cardiomyopathy
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Carrier Proteins / genetics; Cats; Disease Models, Animal; Drosophila; Drosophila melanogaster; Female; Heat-Shock Proteins / genetics; Mutation; RNA, Small Nucleolar / genetics
topics (OpenAlex): Cardiomyopathy and Myosin Studies; Cardiovascular Effects of Exercise; Physiological and biochemical adaptations
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 10, 2021

2019 article

Lisinopril Preserves Physical Resilience and Extends Life Span in a Genotype-Specific Manner in Drosophila melanogaster

Gabrawy, M. M., Campbell, S., Carbone, M. A., Morozova, T. V., Arya, G. H., Turlapati, L. B., … Abadir, P. M. (2019, June 14). The Journals of Gerontology Series A, Vol. 74, pp. 1844–1852.

By: M. Gabrawy*, S. Campbell *, M. Carbone n , T. Morozova n, G. Arya n, L. Turlapati n, J. Walston *, M. Starz-Gaiano * ...

author keywords: Angiotensin; Aging; Locomotion; Muscle; Genetic variation
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Drosophila Proteins / metabolism; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Genotype; Lisinopril / pharmacology; Longevity / drug effects; Male; Peptidyl-Dipeptidase A / metabolism; Phenotype; Transcriptome
topics (OpenAlex): Genetics, Aging, and Longevity in Model Organisms; Genetics and Physical Performance; Physiological and biochemical adaptations
TL;DR: It is demonstrated that skeletal muscle-specific Ance, the Drosophila ortholog of ACE, is involved in physical decline and genetic variation in phenotypic responses to an ACE inhibitor is demonstrated. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: December 30, 2019

2017 journal article

Regulation of Drosophila Lifespan by bellwether Promoter Alleles

Scientific Reports, 7(1).

By: J. Garcia n, M. Carbone n , T. Mackay  n & R. Anholt n

MeSH headings : Alleles; Animals; Drosophila / physiology; Female; Gene Expression Regulation; Gene Knockdown Techniques; Longevity / genetics; Male; Mitochondrial Proton-Translocating ATPases / chemistry; Mitochondrial Proton-Translocating ATPases / genetics; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Protein Subunits / genetics; RNA Interference
topics (OpenAlex): Genetics, Aging, and Longevity in Model Organisms; Neurobiology and Insect Physiology Research; Physiological and biochemical adaptations
TL;DR: Results show that naturally occurring regulatory variants of blw affect lifespan in a sex-specific manner. (via Semantic Scholar)
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Source: Crossref
Added: February 24, 2020

2016 journal article

Genetic architecture of natural variation in visual senescence in Drosophila

Proceedings of the National Academy of Sciences, 113(43), E6620–E6629.

By: M. Carbone n , A. Yamamoto  n, W. Huang  n, R. Lyman  n, T. Meadors n, R. Yamamoto n, R. Anholt n, T. Mackay  n

author keywords: aging; behavioral genetics; DGRP GWA analysis; phototaxis; xQTL mapping
MeSH headings : Aging / genetics; Animals; Biological Variation, Individual; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Drosophila melanogaster / metabolism; Eye Proteins / genetics; Eye Proteins / metabolism; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Genetic Variation; Genome; Genome-Wide Association Study; Humans; Phototaxis; Quantitative Trait Loci; Vision, Ocular / genetics
topics (OpenAlex): Genetics, Aging, and Longevity in Model Organisms; Neurobiology and Insect Physiology Research; Circadian rhythm and melatonin
TL;DR: It is found the genetic basis for visual senescence is distinct from that which determines variation in life span, and genes shaping early development of the nervous system, in particular the visual system, also contribute toSenescence at later age, demonstrating that senescences is part of a genetic continuum throughout the life span. (via Semantic Scholar)
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Added: February 24, 2020

2015 journal article

Genetic architecture of natural variation in Drosophila melanogaster aggressive behavior

Proceedings of the National Academy of Sciences, 112(27), E3555–E3563.

By: J. Shorter  n, C. Couch n, W. Huang  n, M. Carbone n , J. Peiffer n, R. Anholt n, T. Mackay  n

author keywords: Drosophila Genetic Reference Panel; genome-wide association mapping; extreme QTL mapping; advanced intercross population; epistasis
MeSH headings : Aggression; Animals; Crosses, Genetic; Drosophila Proteins / genetics; Drosophila Proteins / physiology; Drosophila melanogaster / classification; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Evolution, Molecular; Genes, Insect / genetics; Genes, Insect / physiology; Genetic Variation; Genome, Insect / genetics; Humans; Inbreeding; Mutation; RNA Interference; Species Specificity
topics (OpenAlex): Neurobiology and Insect Physiology Research; Evolution and Genetic Dynamics; Genetic Mapping and Diversity in Plants and Animals
TL;DR: This work performed genome-wide association analyses using the inbred, sequenced lines of the Drosophila melanogaster Genetic Reference Panel and an advanced intercross population derived from the most and least aggressive DGRP lines to identify genes that have been previously implicated in aggressive behavior as well as many novel loci. (via Semantic Scholar)
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15. Life on Land (Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2015 journal article

Genetic basis of natural variation in body pigmentation in Drosophila melanogaster

Fly, 9(2), 75–81.

By: L. Dembeck n, W. Huang  n, M. Carbone n  & T. Mackay  n

author keywords: Drosophila melanogaster Genetic Reference Panel; extreme QTL mapping; genome wide association study; quantitative genetics; replication study
MeSH headings : Abdomen; Animals; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Female; Gene Expression Regulation / physiology; Genome-Wide Association Study; Pigmentation / genetics; Pigmentation / physiology; Polymorphism, Single Nucleotide; Quantitative Trait Loci
topics (OpenAlex): Invertebrate Immune Response Mechanisms; Insect Utilization and Effects; Neurobiology and Insect Physiology Research
TL;DR: The results of an extreme quantitative trait locus (xQTL) GWA analysis of female body pigmentation in an outbred population derived from light and dark DGRP lines are described. (via Semantic Scholar)
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Added: August 28, 2020

2015 journal article

Genetic basis of transcriptome diversity in Drosophila melanogaster

Proceedings of the National Academy of Sciences, 112(44), E6010–E6019.

By: W. Huang  n, M. Carbone n , M. Magwire n, J. Peiffer n, R. Lyman n, E. Stone  n, R. Anholt n, T. Mackay  n

author keywords: genome-wide association; novel transcribed regions; mean eQTLs; variance eQTLs; epistasis
MeSH headings : Animals; Drosophila melanogaster / genetics; Epistasis, Genetic; Quantitative Trait Loci; Transcriptome
topics (OpenAlex): Genetic Mapping and Diversity in Plants and Animals; Genomics and Phylogenetic Studies; Genetic diversity and population structure
TL;DR: High complexity of the genetic control of gene expression is found, including widespread sexual dimorphism, highly modularized expression patterns with involvement of novel RNA transcripts, and frequent epistatic interactions among expression quantitative trait loci (QTLs) which often give rise to variance expression QTLs. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
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Added: February 24, 2020

2014 journal article

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

Genome Research, 24(7), 1193–1208.

By: W. Huang, A. Massouras, Y. Inoue, J. Peiffer, M. Ramia, A. Tarone, L. Turlapati, T. Zichner ...

Source: NC State University Libraries
Added: August 6, 2018

2013 article

A molecular mechanism for glaucoma: endoplasmic reticulum stress and the unfolded protein response

Anholt, R. R. H., & Carbone, M. A. (2013, July 19). Trends in Molecular Medicine, Vol. 19, pp. 586–593.

By: R. Anholt n & M. Carbone n 

author keywords: primary open angle glaucoma; ocular hypertension; myocilin; neurodegenerative disease
MeSH headings : Animals; Cytoskeletal Proteins / metabolism; Endoplasmic Reticulum Stress; Eye Proteins / metabolism; Glaucoma / pathology; Glycoproteins / metabolism; Humans; Neurodegenerative Diseases / pathology; Translational Research, Biomedical; Unfolded Protein Response
topics (OpenAlex): Glaucoma and retinal disorders; Endoplasmic Reticulum Stress and Disease; Calpain Protease Function and Regulation
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Epistasis dominates the genetic architecture of Drosophila quantitative traits

Proceedings of the National Academy of Sciences, 109(39), 15553–15559.

By: W. Huang, S. Richards *, M. Carbone n , D. Zhu*, R. Anholt n, J. Ayroles, L. Duncan n, K. Jordan  n ...

author keywords: chill coma recovery; genetic interaction networks; genome-wide association studies; startle response; starvation resistance
MeSH headings : Animals; Drosophila melanogaster; Epistasis, Genetic / physiology; Genes, Insect / physiology; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable
topics (OpenAlex): Genetic Mapping and Diversity in Plants and Animals; Genetic diversity and population structure; Genetic and phenotypic traits in livestock
TL;DR: The analysis underscores the importance of epistasis as a principal factor that determines variation for quantitative traits and provides a means to uncover genetic networks affecting these traits. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Source: Crossref
Added: February 24, 2020

2012 journal article

The Drosophila melanogaster Genetic Reference Panel

Nature, 482(7384), 173–178.

By: T. Mackay n, S. Richards *, E. Stone  n, A. Barbadilla *, J. Ayroles  n, D. Zhu*, S. Casillas *, Y. Han * ...

MeSH headings : Alleles; Animals; Centromere / genetics; Chromosomes, Insect / genetics; Drosophila melanogaster / genetics; Genome-Wide Association Study; Genomics; Genotype; Phenotype; Polymorphism, Single Nucleotide / genetics; Quantitative Trait Loci / genetics; Selection, Genetic / genetics; Starvation / genetics; Telomere / genetics; X Chromosome / genetics
topics (OpenAlex): Genetic diversity and population structure; Insect symbiosis and bacterial influences; Genomics and Phylogenetic Studies
TL;DR: The Drosophila melanogaster Genetic Reference Panel is described, a community resource for analysis of population genomics and quantitative traits, which reveals reduced polymorphism in centromeric autosomal regions and the X chromosomes, evidence for positive and negative selection, and rapid evolution of the X chromosome. (via Semantic Scholar)
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Added: February 24, 2020

2011 journal article

Complex genetic architecture of Drosophila aggressive behavior

Proceedings of the National Academy of Sciences, 108(41), 17070–17075.

By: L. Zwarts*, M. Magwire*, M. Carbone* , M. Versteven*, L. Herteleer*, R. Anholt n, P. Callaerts *, T. Mackay*

MeSH headings : Aggression / physiology; Animals; Behavior, Animal / physiology; Brain / anatomy & histology; Crosses, Genetic; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Evolution, Molecular; Female; Gene Expression; Gene Regulatory Networks; Genes, Insect; Male; Mutation; Phenotype
topics (OpenAlex): Neurobiology and Insect Physiology Research; Physiological and biochemical adaptations; Animal Behavior and Reproduction
TL;DR: The transcriptional signatures of homozygous and double heterozygous genotypes derived from the six mutations imply a large mutational target for aggressive behavior and point to evolutionarily conserved genetic mechanisms and neural signaling pathways affecting this universal fitness trait. (via Semantic Scholar)
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15. Life on Land (Web of Science)
Source: Crossref
Added: February 24, 2020

2011 article

Genes of the Unfolded Protein Response Pathway Harbor Risk Alleles for Primary Open Angle Glaucoma

Carbone, M. A., Chen, Y., Hughes, G. A., Weinreb, R. N., Zabriskie, N. A., Zhang, K., & Anholt, R. R. H. (2011, May 31). PLoS ONE, Vol. 6.

By: M. Carbone n , Y. Chen *, G. Hughes*, R. Weinreb *, N. Zabriskie*, K. Zhang *, R. Anholt n

MeSH headings : Aged; Alleles; Female; Genotype; Glaucoma, Open-Angle / genetics; Haplotypes / genetics; Humans; Inhibitor of Apoptosis Proteins / genetics; Linkage Disequilibrium / genetics; Male; Polymorphism, Single Nucleotide / genetics; Protein Disulfide-Isomerases / genetics; Signal Transduction / genetics; Signal Transduction / physiology; Unfolded Protein Response / genetics; Unfolded Protein Response / physiology
topics (OpenAlex): Glaucoma and retinal disorders; Retinal Diseases and Treatments; Flavonoids in Medical Research
TL;DR: Combating genomics approach demonstrates that effectiveness of the UPR in response to accumulation of misfolded or aggregated proteins may contribute to the pathogenesis of POAG and provide targets for early therapeutic intervention. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 article

Alcohol Sensitivity in Drosophila: Translational Potential of Systems Genetics

Morozova, T. V., Ayroles, J. F., Jordan, K. W., Duncan, L. H., Carbone, M. A., Lyman, R. F., … Anholt, R. R. H. (2009, August 4). Genetics, Vol. 183, pp. 733–745.

By: T. Morozova*, J. Ayroles*, K. Jordan*, L. Duncan*, M. Carbone* , R. Lyman*, E. Stone n, D. Govindaraju ...

MeSH headings : Alcohol Drinking / genetics; Animals; Cluster Analysis; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Ethanol / pharmacology; Female; Gene Expression Regulation / drug effects; Gene Regulatory Networks; Genes, Insect / genetics; Genetic Variation; Genome, Insect / genetics; Genome-Wide Association Study / methods; Genotype; Humans; Inbreeding; Malate Dehydrogenase / genetics; Malate Dehydrogenase / metabolism; Male; Phenotype; Polymorphism, Single Nucleotide; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction
topics (OpenAlex): Genetic Mapping and Diversity in Plants and Animals; Genetic Associations and Epidemiology; Bioinformatics and Genomic Networks
TL;DR: Seven intronic single nucleotide polymorphisms of the Malic Enzyme 1 (ME1) gene that are associated with cocktail drinking in 1687 individuals of the Framingham Offspring cohort are identified, implicating that variation in levels of cytoplasmic malic enzyme may contribute to variation in alcohol consumption. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 article

Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep

Harbison, S. T., Carbone, M. A., Ayroles, J. F., Stone, E. A., Lyman, R. F., & Mackay, T. F. C. (2009, February 22). Nature Genetics, Vol. 41, pp. 371–375.

By: S. Harbison n, M. Carbone n , J. Ayroles n, E. Stone n, R. Lyman n & T. Mackay n

MeSH headings : Animals; Animals, Genetically Modified; Animals, Inbred Strains; Drosophila / genetics; Drosophila Proteins / genetics; Female; Gene Expression Regulation / physiology; Gene Regulatory Networks / physiology; Genes, Insect; Genetic Variation / physiology; Genome, Insect; Genome-Wide Association Study / veterinary; Male; Models, Biological; Molecular Sequence Data; Polymorphism, Genetic; Sleep / genetics
topics (OpenAlex): Neurobiology and Insect Physiology Research; Insect and Arachnid Ecology and Behavior; Invertebrate Immune Response Mechanisms
TL;DR: It is independently confirmed that molecular polymorphisms in Catsup (Catecholamines up) are associated with variation in sleep and that P-element mutations in four candidate genes affect sleep and gene expression and co-regulated gene expression using P- element mutants are confirmed. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 article

Systems genetics of complex traits in Drosophila melanogaster

Ayroles, J. F., Carbone, M. A., Stone, E. A., Jordan, K. W., Lyman, R. F., Magwire, M. M., … Mackay, T. F. C. (2009, February 22). Nature Genetics, Vol. 41, pp. 299–307.

By: J. Ayroles n, M. Carbone n , E. Stone n, K. Jordan n, R. Lyman n, M. Magwire n, S. Rollmann n, L. Duncan n ...

MeSH headings : Amino Acid Sequence; Animals; Animals, Inbred Strains; Base Sequence; Chromosome Mapping; Drosophila melanogaster / genetics; Female; Gene Regulatory Networks / physiology; Genetic Variation / physiology; Genetics, Population / methods; Male; Molecular Sequence Data; Phenotype; Quantitative Trait, Heritable; RNA, Messenger / analysis; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sequence Homology, Amino Acid; Tissue Distribution
topics (OpenAlex): Neurobiology and Insect Physiology Research; Genetic Mapping and Diversity in Plants and Animals; Bioinformatics and Genomic Networks
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15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Gene–Environment Contributions to the Development of Infant Vagal Reactivity: The Interaction of Dopamine and Maternal Sensitivity

Propper, C., Moore, G. A., Mills-Koonce, W. R., Halpern, C. T., Hill-Soderlund, A. L., Calkins, S. D., … Cox, M. (2008, September 1). Child Development, Vol. 79, pp. 1377–1394.

By: C. Propper *, G. Moore *, W. Mills-Koonce *, C. Halpern *, A. Hill-Soderlund *, S. Calkins *, M. Carbone n , M. Cox*

MeSH headings : Adolescent; Adult; Alleles; Child, Preschool; Dopamine / physiology; Environment; Female; Genotype; Humans; Infant; Male; Mothers / psychology; Receptors, Dopamine D2 / genetics; Receptors, Dopamine D4 / genetics; Vagus Nerve / physiology
topics (OpenAlex): Child and Adolescent Psychosocial and Emotional Development; Neuroscience of respiration and sleep; Infant Health and Development
TL;DR: Investigation of dopamine receptor genes and maternal sensitivity as predictors of infant respiratory sinus arrhythmia and RSA reactivity and revealed that at 3 and 6 months, RSA withdrawal in response to maternal separation was greater than expected in infants without the DRD2 risk allele than those with the risk allele. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Phenotypic Plasticity and Genotype by Environment Interaction for Olfactory Behavior inDrosophila melanogaster

Sambandan, D., Carbone, M. A., Anholt, R. R. H., & Mackay, T. F. C. (2008, May 28). Genetics, Vol. 179, pp. 1079–1088.

By: D. Sambandan  n, M. Carbone n , R. Anholt n & T. Mackay n

MeSH headings : Animals; Behavior, Animal; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Environment; Female; Gene Expression Profiling; Genes, Insect; Genetic Complementation Test; Genetic Variation; Genotype; Male; Mutation; Oligonucleotide Array Sequence Analysis; Phenotype; Phylogeny; Quantitative Trait Loci; Reverse Transcriptase Polymerase Chain Reaction; Smell / genetics; Smell / physiology; Transferrin / genetics
topics (OpenAlex): Neurobiology and Insect Physiology Research; Invertebrate Immune Response Mechanisms; Insect Utilization and Effects
TL;DR: It is found that ∼50% of phenotypic variation in adult olfactory behavior is attributable to GEI, and transcriptional analysis revealed that only 20 genes show GEI at the level of gene expression [false discovery rate (FDR) < 0.05], some of which are associated with physiological responses to environmental chemicals. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Parenting quality, DRD4, and the prediction of externalizing and internalizing behaviors in early childhood

Developmental Psychobiology, 49(6), 619–632.

By: C. Propper *, M. Willoughby *, C. Halpern *, M. Carbone n  & M. Cox*

author keywords: dopamine; externalizing behavior; internalizing behavior; maternal sensitivity; parenting; gene-environment interactions
MeSH headings : Child; Child Behavior; Child, Preschool; Environment; Female; Genotype; Humans; Infant; Male; Maternal Behavior; Parent-Child Relations; Parenting; Polymorphism, Genetic / genetics; Prospective Studies; Receptors, Dopamine D4 / genetics; Socioeconomic Factors
topics (OpenAlex): Child and Adolescent Psychosocial and Emotional Development; Early Childhood Education and Development; Neuroendocrine regulation and behavior
TL;DR: Results revealed that high warm-responsive parenting was associated with decreased externalizing behavior only for African American children possessing the short polymorphism of DRD4, indicating that children may be differentially susceptible to different aspects of parenting depending on their genotype. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2006 article

Phenotypic Variation and Natural Selection at Catsup, a Pleiotropic Quantitative Trait Gene in Drosophila

Carbone, M. A., Jordan, K. W., Lyman, R. F., Harbison, S. T., Leips, J., Morgan, T. J., … Mackay, T. F. C. (2006, May 1). Current Biology, Vol. 16, pp. 912–919.

By: M. Carbone n , K. Jordan n, R. Lyman n, S. Harbison  n, J. Leips*, T. Morgan n, M. DeLuca n, P. Awadalla n, T. Mackay n

MeSH headings : Animals; Catecholamines / metabolism; Drosophila / anatomy & histology; Drosophila / genetics; Drosophila Proteins / chemistry; Drosophila Proteins / genetics; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Female; Genetic Variation; Genotype; Longevity / genetics; Male; Molecular Sequence Data; Motor Activity / genetics; Phenotype; Quantitative Trait Loci; Quantitative Trait, Heritable; Selection, Genetic
topics (OpenAlex): Insect symbiosis and bacterial influences; Genetic Mapping and Diversity in Plants and Animals; Insect Resistance and Genetics
TL;DR: Molecular population genetic analyses of Catsup sequences are consistent with balancing selection maintaining multiple functional polymorphisms and identify potentially functional variants in protein coding regions that have large effects and are not common. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 article

Quantitative Trait Loci Affecting the Difference in Pigmentation BetweenDrosophila yakubaandD. santomea

Carbone, M. A., Llopart, A., deAngelis, M., Coyne, J. A., & Mackay, T. F. C. (2005, June 22). Genetics, Vol. 171, pp. 211–225.

By: M. Carbone n , A. Llopart *, M. deAngelis*, J. Coyne* & T. Mackay n

MeSH headings : Animals; Chromosome Mapping; Crosses, Genetic; Epistasis, Genetic; Female; Genes, Insect / genetics; Genetic Variation; Genotype; Haplotypes; Hybridization, Genetic; Male; Quantitative Trait Loci / genetics; Skin Pigmentation / genetics; Species Specificity
topics (OpenAlex): Plant Pathogens and Fungal Diseases; Leaf Properties and Growth Measurement; Genetic Mapping and Diversity in Plants and Animals
TL;DR: Using quantitative trait locus (QTL) mapping, the genetic basis of the difference in pigmentation between two sister species of Drosophila is studied, consistent with adaptive evolution driven by directional natural selection. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

journal article

Complex genetic architecture of Drosophila aggressive behavior

Zwarts, L., Magwire, M. M., Carbone, M. A., Versteven, M., Herteleer, L., Anholt, R. R. H., … Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 108(41), 17070–17075.

By: L. Zwarts, M. Magwire, M. Carbone , M. Versteven, L. Herteleer, R. Anholt, P. Callaerts, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Epistasis dominates the genetic architecture of Drosophila quantitative traits

Huang, W., Richards, S., Carbone, M. A., Zhu, D. H., Anholt, R. R. H., Ayroles, J. F., … Muzny, D. Proceedings of the National Academy of Sciences of the United States of America, 109(39), 15553–15559.

By: W. Huang, S. Richards, M. Carbone , D. Zhu, R. Anholt, J. Ayroles, L. Duncan, K. Jordan ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic architecture of natural variation in visual senescence in Drosophila

Carbone, M. A., Yamamoto, A., Huang, W., Lyman, R. A., Meadors, T. B., Yamamoto, R., … Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 113(43), E6620–6629.

By: M. Carbone , A. Yamamoto, W. Huang, R. Lyman, T. Meadors, R. Yamamoto, R. Anholt, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic basis of natural variation in body pigmentation in Drosophila melanogaster

Dembeck, L. M., Huang, W., Carbone, M. A., & Mackay, T. F. C. Fly, 9(2), 75–81.

By: L. Dembeck, W. Huang, M. Carbone  & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic basis of transcriptome diversity in Drosophila melanogaster

Huang, W., Carbone, M. A., Magwire, M. M., Peiffer, J. A., Lyman, R. F., Stone, E. A., … Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 112(44), E6010–6019.

By: W. Huang, M. Carbone , M. Magwire, J. Peiffer, R. Lyman, E. Stone, R. Anholt, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic mapping uncovers cis-regulatory landscape of RNA editing

Ramaswami, G., Deng, P., Zhang, R., Carbone, M. A., Mackay, T. F. C., & Li, J. B. Nature Communications, 6.

By: G. Ramaswami, P. Deng, R. Zhang, M. Carbone , T. Mackay & J. Li

Source: NC State University Libraries
Added: August 6, 2018

journal article

Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: Implications for glaucoma

Carbone, M. A., Ayroles, J. F., Yamamoto, A., Morozova, T. V., West, S. A., Magwire, M. M., … Anholt, R. R. H. PLoS One, 4(1).

By: M. Carbone , J. Ayroles, A. Yamamoto, T. Morozova, S. West, M. Magwire, T. Mackay, R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Quantitative and molecular genetic analyses of mutations increasing Drosophila life span

Magwire, M. M., Yamamoto, A., Carbone, M. A., Roshina, N. V., Symonenko, A. V., Pasyukova, E. G., … Mackay, T. F. C. PLoS Genetics, 6(7).

By: M. Magwire, A. Yamamoto, M. Carbone , N. Roshina, A. Symonenko, E. Pasyukova, T. Morozova, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Quantitative genomics of locomotor behavior in Drosophila melanogaster

Jordan, K. W., Carbone, M. A., Yamamoto, A., Morgan, T. J., & Mackay, T. F. Genome Biology, 8(8).

By: K. Jordan, M. Carbone , A. Yamamoto, T. Morgan & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Regulation of Drosophila lifespan by bellwether promoter alleles

Garcia, J. F., Carbone, M. A., Mackay, T. F. C., & Anholt, R. R. H. Scientific Reports, 7.

By: J. Garcia, M. Carbone , T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Spontaneous mutations and the origin and maintenance of quantitative genetic variation

Huang, W., Lyman, R. F., Lyman, R. A., Carbone, M. A., Harbison, S. T., Magwire, M. M., & Mackay, T. F. C. Elife, 5.

By: W. Huang, R. Lyman, R. Lyman, M. Carbone , S. Harbison, M. Magwire, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

The Drosophila melanogaster genetic reference panel

Mackay, T. F. C., Richards, S., Stone, E. A., Barbadilla, A., Ayroles, J. F., Zhu, D. H., … Carbone, M. A. Nature, 482(7384), 173–178.

By: T. Mackay, S. Richards, E. Stone, A. Barbadilla, J. Ayroles, D. Zhu, S. Casillas, Y. Han ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

The effects of royal jelly on fitness traits and gene expression in Drosophila melanogaster

Shorter, J. R., Geisz, M., Ozsoy, E., Magwire, M. M., Carbone, M. A., & Mackay, T. F. C. PLoS One, 10(7).

By: J. Shorter, M. Geisz, E. Ozsoy, M. Magwire, M. Carbone  & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

The genomic basis of postponed senescence in Drosophila melanogaster

Carnes, M. U., Campbell, T., Huang, W., Butler, D. G., Carbone, M. A., Duncan, L. H., … Mackay, T. F. C. PLoS One, 10(9).

By: M. Carnes, T. Campbell, W. Huang, D. Butler, M. Carbone , L. Duncan, S. Harbajan, E. King ...

Source: NC State University Libraries
Added: August 6, 2018

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