Works (201)

Updated: April 4th, 2024 21:10

2023 journal article

Natural genetic variation in a dopamine receptor is associated with variation in female fertility in Drosophila melanogaster

author keywords: diallel cross design; GWAS; RNAi; Dop2R
MeSH headings : Animals; Female; Drosophila melanogaster / physiology; Genome-Wide Association Study; Drosophila / genetics; Fertility; Genetic Variation
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: May 30, 2023

2021 journal article

Epistasis for head morphology in Drosophila melanogaster

G3-GENES GENOMES GENETICS, 11(10).

By: E. Ozsoy*, M. Yilmaz*, B. Patlar*, G. Emecen*, E. Durmaz*, M. Magwire*, S. Zhou*, W. Huang*, R. Anholt n, T. Mackay n

author keywords: Drosophila Genetic Reference Panel; genome-wide association analyses; modifier loci; genetic interaction network
MeSH headings : Alleles; Animals; Chromosome Mapping; Drosophila melanogaster / genetics; Epistasis, Genetic; Genome-Wide Association Study
TL;DR: The Drosophila melanogaster Genetic Reference Panel of sequenced inbred lines is used to evaluate the magnitude of naturally occurring epistasis modifying the effects of mutations in jing and inv, two transcription factors that have subtle quantitative effects on head morphology as homozygotes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: January 10, 2022

2021 journal article

Functional Diversification, Redundancy, and Epistasis among Paralogs of the Drosophila melanogaster Obp50a-d Gene Cluster

MOLECULAR BIOLOGY AND EVOLUTION, 38(5), 2030–2044.

By: J. Johnstun n, V. Shankar*, S. Mokashi n, L. Sunkara*, U. Ihearahu*, R. Lyman*, T. Mackay n, R. Anholt n

author keywords: multigene families; functional diversification; transcriptional niche; RNAseq; odorant-binding proteins; evolutionary genetics
MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Epistasis, Genetic; Evolution, Molecular; Fat Body / metabolism; Female; Genitalia, Male / metabolism; Male; Multigene Family; Phenotype; Pupa / metabolism; Receptors, Odorant / genetics; Receptors, Odorant / metabolism
TL;DR: There is functional diversification within the Obp50 cluster with Ob p50a contributing to development and Obp 50d to stress resistance, and the deletion–reinsertion approach applied provides a general paradigm for the genetic dissection of paralogs of multigene families. (via Semantic Scholar)
Source: Web Of Science
Added: June 10, 2021

2021 journal article

Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(23).

By: B. Baker*, M. Carbone n, W. Huang*, R. Anholt* & T. Mackay*

author keywords: extreme QTL genome-wide association mapping; Drosophila Genetic Reference Panel; RNA interference; advanced intercross population
MeSH headings : Animals; Cocaine / pharmacology; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster; Epistasis, Genetic; Female; Genome-Wide Association Study; Humans; Male; Methamphetamine / pharmacology; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Sex Characteristics
TL;DR: It is shown that the genetic architecture underlying variation in voluntary cocaine and methamphetamine consumption differs between sexes and is dominated by variants in genes associated with connectivity and function of the nervous system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 23, 2021

2021 journal article

Heat shock proteins and small nucleolar RNAs are dysregulated in a Drosophila model for feline hypertrophic cardiomyopathy

G3-GENES GENOMES GENETICS, 11(1).

By: C. Tallo n, L. Duncan n, A. Yamamoto n, J. Slaydon n, G. Arya n, L. Turlapati n, T. Mackay*, M. Carbone n

author keywords: MYBPC3; cMyBP-C; Drosophila melanogaster; feline HCM; hypertrophic cardiomyopathy
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Carrier Proteins / genetics; Cats; Disease Models, Animal; Drosophila; Drosophila melanogaster; Female; Heat-Shock Proteins / genetics; Mutation; RNA, Small Nucleolar / genetics
Source: Web Of Science
Added: June 10, 2021

2020 journal article

Context-dependent genetic architecture of Drosophila life span

PLOS BIOLOGY, 18(3).

By: W. Huang n, T. Campbell n, M. Carbone n, W. Jones n, D. Unselt n, R. Anholt n, T. Mackay n

MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Gene-Environment Interaction; Genetic Variation; Genome-Wide Association Study; Longevity / genetics; Male; RNA Interference; Temperature
TL;DR: The results implicate novel candidate genes affecting life span and suggest that variation for life span may be maintained by variable allelic effects in heterogeneous environments. (via Semantic Scholar)
Source: Web Of Science
Added: April 20, 2020

2020 journal article

Gene expression networks in the Drosophila Genetic Reference Panel

GENOME RESEARCH, 30(3), 485–496.

By: L. Everett n, W. Huang n, S. Zhou n, M. Carbone n, R. Lyman n, G. Arya n, M. Geisz n, J. Ma* ...

MeSH headings : Animals; DNA Transposable Elements; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Drosophila melanogaster / microbiology; Female; Gene Expression Regulation; Gene Regulatory Networks; Genetic Variation; High-Throughput Nucleotide Sequencing; Male; Microbiota / genetics; Quantitative Trait Loci; Sequence Analysis, RNA
TL;DR: This study performed deep RNA sequencing of 200 Drosophila Genetic Reference Panel inbred lines with complete genome sequences and mapped expression quantitative trait loci for annotated genes, novel transcribed regions, transposable elements and microbial species, providing new insights regarding the role of natural genetic variation in regulating gene expression. (via Semantic Scholar)
Source: Web Of Science
Added: April 14, 2020

2020 journal article

Genetic Basis of Increased Lifespan and Postponed Senescence in Drosophila melanogaster

G3-GENES GENOMES GENETICS, 10(3), 1087–1098.

By: G. Parker n, N. Kohn, A. Spirina, A. McMillen, W. Huang* & T. Mackay n

author keywords: Laboratory evolution; candidate genes; RNAi
MeSH headings : Aging / genetics; Animals; Drosophila melanogaster / genetics; Female; Gene Expression; Genes, Insect; Longevity / genetics; Male; Ovary / metabolism; RNA Interference; Reproduction / genetics
TL;DR: Identifying evolutionarily conserved genes affecting increased lifespan and delayed reproductive senescence is the first step toward understanding the evolutionary forces that maintain segregating variation at these loci in nature and may provide potential targets for therapeutic intervention to delay senescences while increasing lifespan. (via Semantic Scholar)
Source: Web Of Science
Added: May 8, 2020

2020 journal article

Genetic Basis of Natural Variation in Spontaneous Grooming in Drosophila melanogaster

G3-GENES GENOMES GENETICS, 10(9), 3453–3460.

By: A. Yanagawa*, W. Huang*, A. Yamamoto n, A. Wada-Katsumata n, C. Schal n & T. Mackay*

Contributors: A. Yanagawa*, W. Huang*, A. Yamamoto n, A. Wada-Katsumata n, C. Schal n & T. Mackay*

author keywords: Drosophila Genetic Reference Panel; genome wide association analysis; RNA interference; behavioral genetics
MeSH headings : Animals; Drosophila melanogaster / genetics; Epistasis, Genetic; Female; Genetic Variation; Genome-Wide Association Study; Grooming
TL;DR: Although grooming behavior is highly correlated between males and females, significant sex by genotype interactions are observed, indicating that the genetic basis of spontaneous grooming is partially distinct in the two sexes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 5, 2020

2020 journal article

Genotype by environment interaction for gene expression in Drosophila melanogaster

NATURE COMMUNICATIONS, 11(1).

By: W. Huang n, M. Carbone n, R. Lyman n, R. Anholt n & T. Mackay n

MeSH headings : Animals; Drosophila melanogaster / genetics; Female; Gene Expression; Gene Expression Regulation; Gene Regulatory Networks; Gene-Environment Interaction; Genes, Insect; Genetic Variation; Genotype; Male; Quantitative Trait Loci; RNA-Seq; Temperature; Transcriptome
TL;DR: It is shown that developing under different temperatures changes the genetic architecture of regulatory variation in Drosophila melanogaster gene expression yet the co- expression network remains robust, and data suggest that stabilizing selection on gene expression may promote co-expression network robustness. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 30, 2020

2020 journal article

Leveraging Multiple Layers of Data To Predict Drosophila Complex Traits

G3-GENES GENOMES GENETICS, 10(12), 4599–4613.

By: F. Morgante n, W. Huang n, P. Sorensen*, C. Maltecca n & T. Mackay n

author keywords: Genomic prediction; Transcriptomic prediction; Gene Ontology informed prediction; Drosophila Genetic Reference Panel; GenPred; Shared data resources
MeSH headings : Animals; Drosophila; Drosophila melanogaster / genetics; Female; Genotype; Male; Models, Genetic; Multifactorial Inheritance; Phenotype; Polymorphism, Single Nucleotide
TL;DR: This study shows that integrating different sources of information can improve prediction accuracy, especially when large samples are not available, as well as a limited number of GO terms were strongly predictive of the traits. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 4, 2021

2020 journal article

Rapid and Predictable Evolution of Admixed Populations Between Two Drosophila Species Pairs

GENETICS, 214(1), 211–230.

By: D. Matute*, A. Comeault*, E. Earley*, A. Serrato-Capuchina*, D. Peede*, A. Monroy-Eklund*, W. Huang n, C. Jones*, T. Mackay n, J. Coyne*

author keywords: hybridization; introgression; reproductive isolation; speciation
MeSH headings : Animals; Biological Evolution; Chromosome Mapping; Drosophila / classification; Drosophila / genetics; Genetic Speciation; Genetic Variation; Genetics, Population; Genome; Hybridization, Genetic; Reproduction; Sexual Behavior, Animal
TL;DR: The results indicate that nearly all foreign genes were quickly eliminated after hybridization and that selection against the minor species genome might be similar across experimental replicates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: January 21, 2020

2020 journal article

Systems genetics of the Drosophila metabolome

GENOME RESEARCH, 30(3), 392–405.

By: S. Zhou n, F. Morgante n, M. Geisz n, J. Ma*, R. Anholt n & T. Mackay n

MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Female; Genetic Association Studies; Genetic Variation; Male; Metabolome / genetics; Phenotype; Quantitative Trait Loci
TL;DR: This work identified sex-specific modules of genetically correlated metabolites and constructed networks that integrate DNA sequence variation and variation in gene expression with variation in metabolites and organismal traits, including starvation stress resistance and male aggression. (via Semantic Scholar)
Source: Web Of Science
Added: April 14, 2020

2019 journal article

Genetics of cocaine and methamphetamine consumption and preference in Drosophila melanogaster

PLOS GENETICS, 15(5).

By: C. Highfill n, B. Baker n, S. Stevens n, R. Anholt n & T. Mackay n

MeSH headings : Animals; Central Nervous System Stimulants / metabolism; Cocaine / metabolism; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins / antagonists & inhibitors; Dopamine Plasma Membrane Transport Proteins / genetics; Dopamine Plasma Membrane Transport Proteins / metabolism; Dopaminergic Neurons / metabolism; Drosophila Proteins / antagonists & inhibitors; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Feeding Behavior; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Genome, Insect; Male; Methamphetamine / metabolism; Mushroom Bodies / metabolism; Mushroom Bodies / physiopathology; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; Sex Characteristics; Substance-Related Disorders / genetics; Substance-Related Disorders / metabolism; Substance-Related Disorders / physiopathology
Source: Web Of Science
Added: June 24, 2019

2019 journal article

Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster

BEHAVIOR GENETICS, 49(1), 60–82.

By: S. Harbison n, S. Kumar*, W. Huang n, L. McCoy n, K. Smith* & T. Mackay n

author keywords: Drosophila melanogaster; Circadian rhythms; Genome-wide association; Period; Rhythmicity index
MeSH headings : Animals; Chromosome Mapping / methods; Circadian Rhythm / genetics; Drosophila Proteins / metabolism; Drosophila Proteins / physiology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic / genetics; Genetic Variation / genetics; Genome-Wide Association Study / methods; Genotype; Mutation / genetics; Phenotype; Sex Characteristics
TL;DR: The observed differences among transcripts for nine genes predicted to interact among themselves and canonical clock genes in the long period line and a control reveal that complex genetic interactions influence high levels of variation in circadian phenotypes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 28, 2019

2019 journal article

Lisinopril Preserves Physical Resilience and Extends Life Span in a Genotype-Specific Manner in Drosophila melanogaster

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 74(12), 1844–1852.

By: M. Gabrawy*, S. Campbell*, M. Carbone n, T. Morozova n, G. Arya n, L. Turlapati n, J. Walston*, M. Starz-Gaiano* ...

author keywords: Angiotensin; Aging; Locomotion; Muscle; Genetic variation
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Drosophila Proteins / metabolism; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Genotype; Lisinopril / pharmacology; Longevity / drug effects; Male; Peptidyl-Dipeptidase A / metabolism; Phenotype; Transcriptome
TL;DR: It is demonstrated that skeletal muscle-specific Ance, the Drosophila ortholog of ACE, is involved in physical decline and genetic variation in phenotypic responses to an ACE inhibitor is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: December 30, 2019

2018 journal article

Effect of genetic architecture on the prediction accuracy of quantitative traits in samples of unrelated individuals

HEREDITY, 120(6), 500–514.

By: F. Morgante n, W. Huang n, C. Maltecca n & T. Mackay n

MeSH headings : Algorithms; Alleles; Animals; Computer Simulation; Data Interpretation, Statistical; Databases, Genetic; Drosophila melanogaster / genetics; Epistasis, Genetic; Gene Frequency; Genetic Association Studies; Genetic Variation; Genetics, Population; Genome-Wide Association Study / methods; Genotype; Linkage Disequilibrium; Models, Genetic; Quantitative Trait Loci; Quantitative Trait, Heritable; Reproducibility of Results
TL;DR: The results indicate that accounting for genetic architecture can improve prediction accuracy for quantitative traits, especially when predictions are informed by the genetic architecture inferred from mapping the top variants affecting main effects and interactions in the training data, provided there is sufficient power for mapping. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

Estimating Realized Heritability in Panmictic Populations

GENETICS, 208(1), 89–95.

By: M. Lstiburek*, V. Bittner*, G. Hodge n, J. Picek* & T. Mackay n

author keywords: quantitative genetics; Hardy-Weinberg equilibrium; panmictic population
MeSH headings : Algorithms; Body Height; Computer Simulation; Genetics, Population; Humans; Inheritance Patterns; Models, Genetic; Pedigree; Phenotype; Quantitative Trait, Heritable; Selection, Genetic
TL;DR: This work presents a method for estimating realized h2 based on a simple assessment of a random-mating population with no artificial manipulation of the population structure, and derives unbiased estimates of h2 from the mathematical derivation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Evaluation of genes associated with human myxomatous mitral valve disease in dogs with familial myxomatous mitral valve degeneration

VETERINARY JOURNAL, 232, 16–19.

By: K. Meurs n, S. Friedenberg*, B. Williams n, B. Keene n, C. Atkins n, D. Adin n, B. Aona n, T. DeFrancesco n ...

author keywords: Canine; Cavalier King Charles spaniel; Dachshund; Genetic; Mitral valve; Myxomatous valve
MeSH headings : Animals; DNA / blood; Dog Diseases / genetics; Dogs; Heart Valve Diseases / genetics; Heart Valve Diseases / veterinary; Humans; Mitral Valve; Mitral Valve Prolapse / genetics; Mutation; Species Specificity; Whole Genome Sequencing / veterinary
TL;DR: Although mitral valve disease in the CKCS and Dachshund is a familial disease, it was hypothesized that a genetic mutation associated with the development of the human form of MMVD was associated withthe development of canine MMVD and this work identified genetic cause in the genes responsible for the human disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Relationship Between Sequence Homology, Genome Architecture, and Meiotic Behavior of the Sex Chromosomes in North American Voles

GENETICS, 210(1), 83–97.

By: B. Dumont n, C. Williams n, B. Ng*, V. Horncastle*, C. Chambers*, L. McGraw n, D. Adams*, T. Mackay n, M. Breen n

author keywords: pseudoautosomal region; Microtus heterochromatin; telomeric repeats; meiotic synapsis
MeSH headings : Animals; Arvicolinae / genetics; Chromosome Segregation / genetics; Genomics / methods; Meiosis / genetics; North America; Pseudoautosomal Regions / genetics; Sequence Analysis, DNA / methods; Sequence Homology, Nucleic Acid; Sex Chromosomes / genetics; Telomere / genetics; Telomere-Binding Proteins / genetics; X Chromosome / genetics; Y Chromosome / genetics
TL;DR: Key conditions required to sustain the standard program of X/Y synapsis at meiosis are suggested and an intriguing connection between heterochromatic repeat architecture and noncanonical, asynaptic mechanisms of sex chromosome segregation in voles is revealed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: October 19, 2018

2016 journal article

Artificial selection on chill-coma recovery time in Drosophila melanogaster: Direct and correlated responses to selection

JOURNAL OF THERMAL BIOLOGY, 59, 77–85.

By: A. Gerken*, T. Mackay n & T. Morgan*

author keywords: Cross-tolerance; Chill-coma recovery; Drosophila melanogaster; Artificial selection
MeSH headings : Acclimatization; Animal Nutritional Physiological Phenomena; Animals; Breeding; Cold Temperature; Cold-Shock Response; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Male; Phenotype; Selection, Genetic; Stress, Physiological
TL;DR: The results suggest that although artificial selection has dramatically altered chill-coma recovery time, the correlated response to selection on other stress response phenotypes has been negligible, and the lack of a correlated response suggests that chill- COMA recovery time in these selection lines is likely genetically independent from measures of cold survivorship tested here. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Natural variability in Drosophila larval and pupal NaCl tolerance

JOURNAL OF INSECT PHYSIOLOGY, 88, 15–23.

By: C. Riedl*, S. Oster*, M. Busto*, T. Mackay n & M. Sokolowski*

author keywords: QTL; NaCl; Natural variation; Drosophila melanogaster; Pupation position
MeSH headings : Animals; Culture Media; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Larva / genetics; Larva / growth & development; Pupa / genetics; Pupa / growth & development; Quantitative Trait Loci / genetics; Salt Tolerance / genetics; Salt Tolerance / physiology
TL;DR: This work describes four D. melanogaster lines that were selected for different degrees of NaCl tolerance, and present data on their survival, development, and pupation position when raised on varying NaCl concentrations, and presents the results of Quantitative Trait Loci mapping of natural variation in larval and pupal NaClolerance. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Genetic Architecture of Micro-Environmental Plasticity in Drosophila melanogaster

Scientific Reports, 5(1).

MeSH headings : Acclimatization / genetics; Animals; Cell Plasticity / genetics; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Ecosystem; Gene-Environment Interaction; Genetic Fitness / genetics; Quantitative Trait Loci / genetics
TL;DR: This work quantified genetic variation for micro-environmental plasticity for three quantitative traits in the inbred, sequenced lines of the Drosophila melanogaster Genetic Reference Panel and identified several candidate genes associated with micro-Environmental plasticity of startle response, including Drosophile Hsp90. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2014 journal article

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

Genome Research, 24(7), 1193–1208.

By: W. Huang, A. Massouras, Y. Inoue, J. Peiffer, M. Ramia, A. Tarone, L. Turlapati, T. Zichner ...

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Alcohol Sensitivity in Drosophila: Translational Potential of Systems Genetics

GENETICS, 183(2), 733–745.

By: T. Morozova*, J. Ayroles*, K. Jordan*, L. Duncan*, M. Carbone*, R. Lyman*, E. Stone n, D. Govindaraju ...

MeSH headings : Alcohol Drinking / genetics; Animals; Cluster Analysis; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Ethanol / pharmacology; Female; Gene Expression Regulation / drug effects; Gene Regulatory Networks; Genes, Insect / genetics; Genetic Variation; Genome, Insect / genetics; Genome-Wide Association Study / methods; Genotype; Humans; Inbreeding; Malate Dehydrogenase / genetics; Malate Dehydrogenase / metabolism; Male; Phenotype; Polymorphism, Single Nucleotide; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction
TL;DR: Seven intronic single nucleotide polymorphisms of the Malic Enzyme 1 (ME1) gene that are associated with cocktail drinking in 1687 individuals of the Framingham Offspring cohort are identified, implicating that variation in levels of cytoplasmic malic enzyme may contribute to variation in alcohol consumption. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep

NATURE GENETICS, 41(3), 371–375.

By: S. Harbison n, M. Carbone n, J. Ayroles n, E. Stone n, R. Lyman n & T. Mackay n

MeSH headings : Animals; Animals, Genetically Modified; Animals, Inbred Strains; Drosophila / genetics; Drosophila Proteins / genetics; Female; Gene Expression Regulation / physiology; Gene Regulatory Networks / physiology; Genes, Insect; Genetic Variation / physiology; Genome, Insect; Genome-Wide Association Study / veterinary; Male; Models, Biological; Molecular Sequence Data; Polymorphism, Genetic; Sleep / genetics
TL;DR: It is independently confirmed that molecular polymorphisms in Catsup (Catecholamines up) are associated with variation in sleep and that P-element mutations in four candidate genes affect sleep and gene expression and co-regulated gene expression using P- element mutants are confirmed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Quantitative Trait Loci for Aggressive Behavior in Drosophila melanogaster

GENETICS, 182(3), 889–897.

By: A. Edwards & T. Mackay n

MeSH headings : Aggression; Analysis of Variance; Animals; Chromosome Mapping; Crosses, Genetic; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Genes, Insect / genetics; Genetic Complementation Test; Genetic Variation; Genome, Insect / genetics; Male; Mutation; Quantitative Trait Loci / genetics
TL;DR: QTL affecting variation in aggression between two wild-type Drosophila strains is mapped and extensive epistasis poses a serious challenge for understanding the genetic basis of complex traits. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Systems genetics of complex traits in Drosophila melanogaster

NATURE GENETICS, 41(3), 299–307.

By: J. Ayroles n, M. Carbone n, E. Stone n, K. Jordan n, R. Lyman n, M. Magwire n, S. Rollmann n, L. Duncan n ...

MeSH headings : Amino Acid Sequence; Animals; Animals, Inbred Strains; Base Sequence; Chromosome Mapping; Drosophila melanogaster / genetics; Female; Gene Regulatory Networks / physiology; Genetic Variation / physiology; Genetics, Population / methods; Male; Molecular Sequence Data; Phenotype; Quantitative Trait, Heritable; RNA, Messenger / analysis; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sequence Homology, Amino Acid; Tissue Distribution
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(34), 12393–12398.

By: A. Yamamoto n, L. Zwarts*, P. Callaerts*, K. Norga*, T. Mackay n & R. Anholt n

author keywords: behavioral genetics; epistasis; sensorimotor integration; startle behavior; P-element insertional mutagenesis
MeSH headings : Animals; DNA Transposable Elements; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Gene Regulatory Networks / physiology; Locomotion / genetics; Locomotion / physiology; Mutation; Nervous System Physiological Phenomena; Reflex, Startle / genetics; Reflex, Startle / physiology
TL;DR: It is found that behavioral and neuroanatomical phenotypes are determined by a common set of genes that are organized as partially overlapping genetic networks. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogaster

GENETICS, 179(2), 1079–1088.

By: D. Sambandan n, M. Carbone n, R. Anholt n & T. Mackay n

MeSH headings : Animals; Behavior, Animal; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Environment; Female; Gene Expression Profiling; Genes, Insect; Genetic Complementation Test; Genetic Variation; Genotype; Male; Mutation; Oligonucleotide Array Sequence Analysis; Phenotype; Phylogeny; Quantitative Trait Loci; Reverse Transcriptase Polymerase Chain Reaction; Smell / genetics; Smell / physiology; Transferrin / genetics
TL;DR: It is found that ∼50% of phenotypic variation in adult olfactory behavior is attributable to GEI, and transcriptional analysis revealed that only 20 genes show GEI at the level of gene expression [false discovery rate (FDR) < 0.05], some of which are associated with physiological responses to environmental chemicals. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structure

GENETICS, 179(3), 1327–1336.

By: S. Rollmann n, L. Zwarts*, A. Edwards n, A. Yamamoto n, P. Callaerts*, K. Norga*, T. Mackay n, R. Anholt n

MeSH headings : Alleles; Alternative Splicing / genetics; Animals; Behavior; Brain / anatomy & histology; DNA Transposable Elements; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Gene Expression Regulation, Developmental; Genes, Insect; Male; Mutagenesis, Insertional; Mutation / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism
TL;DR: The diverse phenotypic effects arising from nearby P-element insertions in neur provide a new appreciation of the concept of allelic effects on phenotype, in which the wild type and null mutant are at the extreme ends of a continuum of pleiotropic allelic Effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Ain't misbehavin? Genotype-environment interactions and the genetics of behavior

TRENDS IN GENETICS, 23(7), 311–314.

By: T. Mackay n & R. Anholt n

MeSH headings : Animals; Behavior, Animal; Crosses, Genetic; Drosophila; Environment; Genetics, Behavioral / methods; Genotype; Mice; Models, Genetic; Phenotype; Species Specificity
TL;DR: The importance of understanding genotype-environment interactions is stressed, together with studies from Drosophila, which show that some behavioral differences between laboratories remain greatly replicable, whereas others are less robust over time. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Association of polymorphisms in odorant-binding protein genes with variation in olfactory response to benzaldehyde in Drosophila

GENETICS, 177(3), 1655–1665.

By: P. Wang*, R. Lyman*, S. Shabalina n, T. Mackay* & R. Anholt*

MeSH headings : Animals; Benzaldehydes; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Genes, Insect; Genetics, Population; Male; Models, Molecular; Molecular Sequence Data; Multigene Family; Nucleic Acid Conformation; Odorants; Phenotype; Polymorphism, Genetic; Polymorphism, Single Nucleotide; RNA Precursors / chemistry; RNA Precursors / genetics; Receptors, Odorant / genetics
TL;DR: Model predictions of alternative pre-mRNA secondary structures associated with polymorphic sites suggest that alterations in Obp mRNA structure could contribute to phenotypic variation in olfactory behavior. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping

MECHANISMS OF AGEING AND DEVELOPMENT, 128(3), 237–249.

author keywords: life span; microarray gene expression; QTL; Drosophila aging
MeSH headings : Aging / genetics; Aging / physiology; Animals; Biomarkers; Chromosome Mapping; Cytochrome P-450 Enzyme System / genetics; Drosophila / genetics; Drosophila / physiology; Energy Metabolism / genetics; Gene Expression Regulation / physiology; Intercellular Signaling Peptides and Proteins / genetics; Longevity / genetics; Oligonucleotide Array Sequence Analysis; Oxidoreductases / genetics; Quantitative Trait Loci / genetics; Signal Transduction / genetics; Signal Transduction / physiology; Transcription, Genetic; Ubiquitin / genetics
TL;DR: This study investigated gene expression changes between two strains of Drosophila for which quantitative trait loci affecting life span were identified previously, and identified 49 candidate genes and four pathways that could potentially be responsible for regulating life span and involved in the process of aging in Drosophile and humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Genetic and behavioral analysis of natural variation in Drosophila melanogaster pupation position

FLY, 1(1), 23–32.

By: C. Riedl*, M. Riedl, T. Mackay* & M. Sokolowski

author keywords: Drosophila; behavior; pupation; wandering; QTL; quantitative; genetics
MeSH headings : Animals; Behavior, Animal; Chromosome Mapping; Drosophila melanogaster / physiology; Genetic Variation; Metamorphosis, Biological; Phenotype; Quantitative Trait Loci
TL;DR: The ability of larvae to integrate several internal and external environmental cues while choosing a contextually appropriate pupation site, and specifically, the variation in this ability, presents a very interesting behavioral phenotype in this highly tractable genetic model organism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Speed-mapping quantitative trait loci using microarrays

NATURE METHODS, 4(10), 839–841.

MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Female; Gene Expression Profiling / methods; Longevity / genetics; Male; Oligonucleotide Array Sequence Analysis / methods; Polymorphism, Genetic / genetics; Quantitative Trait Loci
TL;DR: A rapid, economical method for high-resolution quantitative trait locus (QTL) mapping using microarrays for selective genotyping of pooled DNA samples is developed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

The early developmental gene Semaphorin 5c contributes to olfactory behavior in adult Drosophila

GENETICS, 176(2), 947–956.

By: S. Rollmann n, A. Yamamoto n, T. Goossens*, L. Zwarts*, Z. Callaerts-Vegh, P. Callaerts*, K. Norga*, T. Mackay n, R. Anholt n

MeSH headings : Aging / physiology; Animals; Animals, Genetically Modified; Antibodies, Monoclonal; Avoidance Learning; Behavior, Animal; Benzaldehydes; Cell Adhesion Molecules, Neuronal / immunology; Crosses, Genetic; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Drosophila melanogaster / physiology; Gene Expression Regulation, Developmental; Membrane Glycoproteins / genetics; Mutation; Odorants; Semaphorins / genetics; Smell / physiology
TL;DR: The results demonstrate how hypomorphic mutation of an early developmental gene results in genomewide transcriptional consequences and alterations in brain structure accompanied by profound impairment of adult behavior. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Dynamic genetic interactions determine odor-guided behavior in Drosophila melanogaster

GENETICS, 174(3), 1349–1363.

By: D. Sambandan n, A. Yamamoto n, J. Fanara*, T. Mackay n & R. Anholt n

MeSH headings : Animals; Behavior, Animal; DNA Transposable Elements / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Genes, Insect; Mutagenesis, Insertional; Mutation; Odorants; Smell / genetics; Smell / physiology
TL;DR: The results show that the manifestation of epistatic networks dynamically changes with alterations in the environment, and surprisingly, epistatic interactions shifted with changes in the concentration of the olfactory stimulus. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

High-resolution mapping of quantitative trait loci affecting increased life span in Drosophila melanogaster

GENETICS, 173(3), 1455–1463.

By: R. Wilson, T. Morgan n & T. Mackay n

MeSH headings : Animals; Chromosome Mapping / methods; Drosophila melanogaster / genetics; Female; Genetic Complementation Test; Genetic Variation; Longevity / genetics; Male; Quantitative Trait Loci
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Phenotypic variation and natural selection at Catsup, a pleiotropic quantitative trait gene in Drosphila

CURRENT BIOLOGY, 16(9), 912–919.

By: M. Carbone n, K. Jordan n, R. Lyman n, S. Harbison n, J. Leips*, T. Morgan n, M. DeLuca n, P. Awadalla n, T. Mackay n

MeSH headings : Animals; Catecholamines / metabolism; Drosophila / anatomy & histology; Drosophila / genetics; Drosophila Proteins / chemistry; Drosophila Proteins / genetics; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Female; Genetic Variation; Genotype; Longevity / genetics; Male; Molecular Sequence Data; Motor Activity / genetics; Phenotype; Quantitative Trait Loci; Quantitative Trait, Heritable; Selection, Genetic
TL;DR: Molecular population genetic analyses of Catsup sequences are consistent with balancing selection maintaining multiple functional polymorphisms and identify potentially functional variants in protein coding regions that have large effects and are not common. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster

NATURE GENETICS, 38(7), 824–829.

By: S. Rollmann n, M. Magwire n, T. Morgan n, E. Ozsoy n, A. Yamamoto n, T. Mackay n, R. Anholt n

MeSH headings : Animals; DNA Transposable Elements / genetics; DNA, Intergenic / genetics; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Female; Genes, Insect; Insulin / metabolism; Longevity / genetics; Male; Mutation; Phenotype; Quantitative Trait, Heritable; Receptors, Cell Surface / genetics; Receptors, G-Protein-Coupled / genetics; Repetitive Sequences, Nucleic Acid; Signal Transduction; Taste / genetics
TL;DR: It is demonstrated that single P-element insertions in the intergenic region between the gustatory receptor 5a and trapped in endoderm 1, which encodes an orphan receptor, exert complex pleiotropic effects on fitness traits, including selective nutrient intake, life span, and resistance to starvation and heat stress. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Quantitative genomics of aggressive behavior in Drosophila melanogaster

PLOS GENETICS, 2(9), 1386–1395.

By: A. Edwards n, S. Rollmann n, T. Morgan n & T. Mackay n

MeSH headings : Aggression; Animals; Behavior, Animal; DNA Transposable Elements / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Genes, Insect; Genomics / methods; Mutagenesis, Insertional; Phenotype; Selection, Genetic; Transcription, Genetic
TL;DR: An assay to rapidly quantify aggressive behavior in Drosophila melanogaster is developed, and replicate selection lines with divergent levels of aggression are generated, and 15 novel genes affecting aggressive behavior are identified. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Quantitative trait loci for locomotor behavior in Drosophila melanogaster

GENETICS, 174(1), 271–284.

By: K. Jordan n, T. Morgan n & T. Mackay n

MeSH headings : Animals; Behavior, Animal; Chromosome Mapping / methods; Crosses, Genetic; Drosophila melanogaster / genetics; Female; Genetic Complementation Test; Genome, Insect; Linkage Disequilibrium; Male; Motor Activity / genetics; Quantitative Trait Loci
TL;DR: Linkage disequilibrium mapping in a population of 164 second chromosome substitution lines derived from a single natural population showed that polymorphisms at Ddc were associated with naturally occurring genetic variation in locomotor behavior, implicate variation in the synthesis of bioamines as a factor contributing to natural variation in Locomotor reactivity. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Quantitative trait loci for thermotolerance phenotypes in Drosophila melanogaster

HEREDITY, 96(3), 232–242.

author keywords: chill-coma recovery; environmental stress; heat-stress resistance; temperature stress; QTL
MeSH headings : Adaptation, Physiological / genetics; Animals; Cold Temperature; Drosophila melanogaster / genetics; Genetic Variation; Hot Temperature; Phenotype; Quantitative Trait Loci
TL;DR: A mapping population of recombinant inbred lines is used to map quantitative trait loci (QTL) that affect variation in both heat- and cold-stress resistance in D. melanogaster, suggesting that overlapping but generally unique genetic architectures underlie resistance to low- and high-temperature extremes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 review

Quantitative trait loci with age-specific effects on fecundity in Drosophila melanogaster

[Review of ]. GENETICS, 172(3), 1595–1605.

By: J. Leips n, P. Gilligan n & T. Mackay n

MeSH headings : Aging / genetics; Aging / physiology; Animals; Animals, Inbred Strains; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic / physiology; Female; Fertility / genetics; Genetic Markers; Genetic Variation / physiology; Male; Quantitative Trait Loci
TL;DR: The results suggest that different loci contribute to the variation in fecundity as the organism ages, and provide support for the mutation accumulation theory of aging as applied to reproductive senescence. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

The genetic basis of postzygotic reproductive isolation between Drosophila santomea and D-yakuba due to hybrid male sterility

GENETICS, 173(1), 225–233.

By: A. Moehring n, A. Llopart*, S. Elwyn*, J. Coyne* & T. Mackay n

MeSH headings : Animals; Chromosome Mapping; Chromosomes / genetics; Crosses, Genetic; Drosophila / classification; Drosophila / genetics; Drosophila / physiology; Epistasis, Genetic; Genetic Markers; Hybridization, Genetic; Infertility, Male / genetics; Infertility, Male / physiopathology; Male; Pigmentation / genetics; Quantitative Trait Loci / genetics; Reproduction / genetics; Reproduction / physiology; Species Specificity; Zygote / metabolism
TL;DR: Mapping quantitative trait loci affecting fertility of male hybrids between D. yakuba and its recently discovered sibling species, D. santomea, provides the basis for future high-resolution mapping and ultimately, molecular cloning of the interacting genes that contribute to hybrid sterility. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

The genetic basis of prezygotic reproductive isolation between Drosophila santomea and D-yakuba due to mating preference

GENETICS, 173(1), 215–223.

By: A. Moehring n, A. Llopart*, S. Elwyn*, J. Coyne* & T. Mackay n

MeSH headings : Animals; Chromosome Mapping; Chromosomes / genetics; Drosophila / cytology; Drosophila / genetics; Drosophila / physiology; Genetic Markers; Quantitative Trait Loci / genetics; Reproduction / genetics; Reproduction / physiology; Sexual Behavior, Animal / physiology; Zygote / metabolism
TL;DR: QTL contributing to prezygotic reproductive isolation between the sibling species Drosophila santomea and D. yakuba is mapped and future high-resolution mapping and, ultimately, positional cloning will reveal whether these traits do indeed have a common genetic basis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (OpenAlex)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Drosophila bristles and the nature of quantitative genetic variation

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 360(1459), 1513–1527.

By: T. Mackay & R. Lyman

Source: NC State University Libraries
Added: August 6, 2018

2005 article

Genetics and genomics of Drosophila mating behavior

Mackay, T. F. C., Heinsohn, S. L., Lyman, R. F., Moehring, A. J., Morgan, T. J., & Rollmann, S. M. (2005, May 3). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 102, pp. 6622–6629.

By: T. Mackay n, S. Heinsohn n, R. Lyman n, A. Moehring n, T. Morgan n & S. Rollmann n

MeSH headings : Animals; Chromosomes; Copulation / physiology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Genes, Insect / genetics; Genomics; Male; Phenotype; Sexual Behavior, Animal / physiology; Transcription, Genetic / genetics
TL;DR: Drosophila melanogaster was subjected to 29 generations of replicated divergent artificial selection for mating speed, and the phenotypic response to selection was highly asymmetrical in the direction of reduced mating speed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Microclinal variation for ovariole number and body size in Drosophila melanogaster in 'Evolution Canyon'

GENETICA, 123(3), 263–270.

By: M. Wayne n, A. Korol* & T. Mackay n

author keywords: genetic variation; microspatial; population subdivision; selection
MeSH headings : Adaptation, Biological / genetics; Altitude; Analysis of Variance; Animals; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Evolution, Molecular; Female; Genetic Variation; Israel; Male; Microclimate; Ovary / ultrastructure; Quantitative Trait Loci / genetics
TL;DR: Between-site genetic variation in ovariole number was negatively correlated with altitude on both slopes of the canyon, and collections from the north- and south-facing slopes were genetically differentiated for male, but not female, body size. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Pinocchio, a novel protein expressed in the antenna, contributes to olfactory behavior in Drosophila melanogaster

JOURNAL OF NEUROBIOLOGY, 63(2), 146–158.

author keywords: olfaction; P-element mutagenesis; behavioral genetics; chemoreception
MeSH headings : Amino Acid Sequence; Analysis of Variance; Animals; Avoidance Learning / physiology; Behavior, Animal; Cloning, Molecular; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila Proteins / physiology; Drosophila melanogaster / metabolism; Electrophysiology / methods; Gene Expression / physiology; In Situ Hybridization / methods; Mutagenesis, Insertional / physiology; Naphthalenes; Odorants; Oxepins; Phenotype; RNA, Messenger / metabolism; Receptors, Odorant / genetics; Receptors, Odorant / metabolism; Reverse Transcriptase Polymerase Chain Reaction / methods; Sense Organs / metabolism; Smell / physiology
TL;DR: It is shown that the smi21F mutant also exhibits reduced attractant responses to some, but not all, of a select group of odorants, and electroantennogram amplitudes are increased in smi 21F flies. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Polygenic mutation in Drosophila melanogaster: Mapping spontaneous mutations affecting sensory bristle number

GENETICS, 170(4), 1723–1735.

By: T. Mackay n, R. Lyman n & F. Lawrence n

MeSH headings : Animals; Chromosome Mapping; Drosophila melanogaster / genetics; Genes, Insect; Genetic Complementation Test; Genetic Variation; Genome, Insect; Mutation; Quantitative Trait Loci; Quantitative Trait, Heritable; Selection, Genetic; X Chromosome
TL;DR: Estimates of the numbers of mutations and mutational effects were consistent with diploid per-character mutation rates for bristle traits and imply that >2% of the genome could affect just one bristle trait and that there must be extensive pleiotropy for quantitative phenotypes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Positive assortative mating with family size as a function of predicted parental breeding values

GENETICS, 171(3), 1311–1320.

By: M. Lstiburek n, T. Mullin n, T. Mackay n, D. Huber* & B. Li n

MeSH headings : Analysis of Variance; Computer Simulation; Genetics, Population; Inbreeding; Models, Genetic; Predictive Value of Tests; Trees / genetics
TL;DR: Redistributing progenies from lower- to higher-ranking families to a point where an equal number of progenie were still selected out of each family to the next generation caused minimal change in group coancestry and inbreeding in the breeding population (BP), while the additive genetic response and variance in the BP were both greatly enhanced. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Quantitative trait loci affecting the difference in pigmentation between Drosophila yakuba and D. santomea

GENETICS, 171(1), 211–225.

By: M. Carbone n, A. Llopart*, M. DeAngelis*, J. Coyne* & T. Mackay n

MeSH headings : Animals; Chromosome Mapping; Crosses, Genetic; Epistasis, Genetic; Female; Genes, Insect / genetics; Genetic Variation; Genotype; Haplotypes; Hybridization, Genetic; Male; Quantitative Trait Loci / genetics; Skin Pigmentation / genetics; Species Specificity
TL;DR: Using quantitative trait locus (QTL) mapping, the genetic basis of the difference in pigmentation between two sister species of Drosophila is studied, consistent with adaptive evolution driven by directional natural selection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Accumulation of transposable elements in the genome of Drosophila melanogaster is associated with a decrease in fitness

JOURNAL OF HEREDITY, 95(4), 284–290.

By: E. Pasyukova n, S. Nuzhdin, T. Morozova & T. Mackay

MeSH headings : Analysis of Variance; Animals; Competitive Behavior / physiology; DNA Transposable Elements / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Genome; In Situ Hybridization; Reproduction / genetics; Reproduction / physiology; Selection, Genetic; Species Specificity; Translocation, Genetic / genetics
TL;DR: Both homozygous and heterozygous TE insertions were shown to have deleterious effects on fitness and its components, and higher rates of ectopic exchanges and chromosomal rearrangements resulting in early embryonic death are predicted from an increase in TE copy number. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2004 article

Complementing complexity

Mackay, T. F. C. (2004, November). NATURE GENETICS, Vol. 36, pp. 1145–1147.

By: T. Mackay n

MeSH headings : Animals; Animals, Outbred Strains; Anxiety / genetics; Genetic Complementation Test / methods; Genetic Variation; Mice; Quantitative Trait, Heritable
TL;DR: A new study shows that historical recombination in outbred strains combined with functional complementation tests can identify pleiotropic genes with small effects on naturally occurring variation for anxiety-related behaviors in mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2004 article

Douglas Scott Falconer (1913-2004)

Mackay, T. F. C. (2004, August). HEREDITY, Vol. 93, pp. 119–121.

By: T. Mackay n

MeSH headings : Genetic Linkage / genetics; Genetic Predisposition to Disease; Genetics / history; History, 20th Century; Quantitative Trait, Heritable; Selection, Genetic
TL;DR: Douglas Falconer is best known for his work on response to artificial selection in mice, the concept of the cross-environment genetic correlation, development of the theory for understanding the genetics of complex human diseases in terms of an underlying continuous liability, and his highly acclaimed textbook, Introduction to Quantitative Genetics, first published in 1960. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

No evidence for an association between common nonsynonymous polymorphisms in Delta and bristle number variation in natural and laboratory populations of Drosophila melanogaster

GENETICS, 166(1), 291–306.

By: A. Genissel*, T. Pastinen*, A. Dowell*, T. Mackay n & A. Long*

MeSH headings : 3' Untranslated Regions; Animals; Animals, Laboratory; Animals, Wild; Base Sequence; DNA / genetics; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Exons; Female; Genes, Insect; Genetic Variation; Genetics, Population; Genotype; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins / genetics; Molecular Sequence Data; Phenotype; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Sequence Homology, Nucleic Acid
TL;DR: Results suggest that two previously detected genotype/phenotype associations between bristle number and variants in the introns of Delta cannot be explained by linkage disequilibrium between these variants and nearby nonsynonymous variants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2004 review

Quantitative genetic analyses of complex behaviours in Drosophila

[Review of ]. NATURE REVIEWS GENETICS, 5(11), 838–849.

MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Gene Expression Profiling; Genetics, Behavioral; Genotype; Phenotype; Sex Characteristics; Transcription, Genetic
TL;DR: Drosophila melanogaster provides an attractive system for elucidating the unifying principles of the genetic architectures that drive behaviours, as genetically identical individuals can be reared rapidly in controlled environments and extensive publicly accessible genetic resources are available. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Quantitative trait loci affecting natural variation in Drosophila longevity

MECHANISMS OF AGEING AND DEVELOPMENT, 125(3), 179–189.

By: G. Geiger-Thornsberry n & T. Mackay n

author keywords: QTL mapping; quantitative complementation tests; candidate genes
MeSH headings : Aging / genetics; Animals; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Female; Genetic Complementation Test; Genetic Variation; Longevity / genetics; Male; Quantitative Trait Loci
TL;DR: Several genes that regulate life span complemented the life span effects of wild-derived alleles, suggesting little natural variation affecting longevity at these loci, at least in this sample of alleles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Quantitative trait loci affecting starvation resistance in Drosophila melanogaster

GENETICS, 166(4), 1807–1823.

By: S. Harbison n, A. Yamamoto, J. Fanara, K. Norga & T. Mackay

MeSH headings : Analysis of Variance; Animals; Crosses, Genetic; DNA Transposable Elements / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Genes, Insect / genetics; Genes, Insect / physiology; Genetic Complementation Test; Genetic Variation; Mutation / genetics; Quantitative Trait Loci; Starvation / genetics
TL;DR: The genes identified are involved in oogenesis, metabolism, and feeding behaviors, indicating a possible link to reproduction and survival, and also imply that resource allocation during development and at the cellular level may also influence the phenotypic response to starvation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Quantitative trait loci for sexual isolation between Drosophila simulans and D-mauritiana

GENETICS, 167(3), 1265–1274.

By: A. Moehring n, J. Li n, M. Schug*, S. Smith*, M. deAngelis*, T. Mackay n, J. Coyne*

MeSH headings : Animals; Chromosome Mapping; Crosses, Genetic; DNA Primers; Drosophila / genetics; Drosophila / physiology; Female; Male; Microsatellite Repeats / genetics; Polymorphism, Genetic; Quantitative Trait Loci; Reproduction / genetics; Sexual Behavior, Animal / physiology; Species Specificity
UN Sustainable Development Goal Categories
5. Gender Equality (OpenAlex)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Shuttle craft: a candidate quantitative trait gene for Drosophila lifespan

AGING CELL, 3(5), 297–307.

By: E. Pasyukova*, N. Roshina* & T. Mackay n

author keywords: allele-, sex- and genetic background-specific effects; genetics of aging; QTL mapping; quantitative complementation test
MeSH headings : Aging / genetics; Aging / physiology; Alleles; Animals; Chromosome Mapping; Drosophila Proteins / genetics; Drosophila Proteins / physiology; Drosophila melanogaster / genetics; Female; Longevity / genetics; Longevity / physiology; Phenotype; Quantitative Trait Loci / genetics
Source: Web Of Science
Added: August 6, 2018

2004 review

The genetic architecture of quantitative traits: lessons from Drosophila

[Review of ]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 14(3), 253–257.

By: T. Mackay n

MeSH headings : Animals; Chromosome Mapping; DNA Transposable Elements / genetics; Drosophila / genetics; Genetic Complementation Test; Linkage Disequilibrium / genetics; Mutagenesis / genetics; Quantitative Trait Loci / genetics
TL;DR: Studies in Drosophila have revealed large numbers of pleiotropic genes that interact epistatically to regulate quantitative traits, and large number of QTLs with sex-, environment- and genotype-specific effects, which offer valuable lessons for understanding the genetic basis of variation for complex traits in other organisms, including humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

The quantitative genetic basis of male mating behavior in Drosophila melanogaster

GENETICS, 167(3), 1249–1263.

MeSH headings : Animals; Chromosome Mapping; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Genetic Complementation Test; Male; Quantitative Trait Loci; Sexual Behavior, Animal / physiology
TL;DR: QTL affecting courtship occurrence, courtship latency, copulation occurrence, and copulation latency that segregate between a D. melanogaster strain selected for reduced male mating propensity and a standard wild-type strain are mapped. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Dopa decarboxylase (Ddc) affects variation in Drosophila longevity

NATURE GENETICS, 34(4), 429–433.

MeSH headings : Animals; Base Sequence; Chromosome Mapping; DNA / genetics; Dopa Decarboxylase / genetics; Drosophila melanogaster / enzymology; Drosophila melanogaster / genetics; Female; Genes, Insect; Genetic Complementation Test; Genetic Variation; Longevity / genetics; Male; Molecular Sequence Data; Mutation; Polymorphism, Genetic; Quantitative Trait Loci; Sequence Homology, Nucleic Acid; Species Specificity
TL;DR: Variation in the synthesis of bioamines as a factor contributing to natural variation in individual life span is implicate by mapping quantitative trait loci affecting variation in longevity between two Drosophila melanogaster strains. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Genotype-environment interactions at quantitative trait loci affecting inflorescence development in Arabidopsis thaliana

Genetics, 165(1), 353–365.

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Heterogeneous selection at specific loci in natural environments in Arabidopsis thaliana

Genetics, 165(1), 321–329.

By: C. Weinig, L. Dorn, N. Kane, Z. German, S. Hahdorsdottir, M. Ungerer, Y. Toyonaga, T. Mackay, M. Purugganan, J. Schmitt

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development

CURRENT BIOLOGY, 13(16), 1388–1397.

By: K. Norga*, M. Gurganus n, C. Dilda n, A. Yamamoto n, R. Lyman n, P. Patel*, G. Rubin*, R. Hoskins*, T. Mackay n, H. Bellen*

MeSH headings : Animals; Drosophila / anatomy & histology; Drosophila / genetics; Drosophila / growth & development; Gene Expression Regulation, Developmental; Genes, Insect; Mutation; Peripheral Nerves / growth & development
TL;DR: The findings establish the use of quantitative trait analysis for functional genome annotation through forward genetics, and similar analyses of quantitative effects of P element insertions will facilitate the understanding of the genes affecting many other complex traits in Drosophila. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Scribble is essential for olfactory Behavior in Drosphila melanogaster

Genetics, 164(4), 1447–1457.

By: I. Ganguly, T. MacKay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

The genetic architecture of odor-guided behavior in Drosophila: epistasis and the transcriptome

NATURE GENETICS, 35(2), 180–184.

By: R. Anholt n, C. Dilda n, S. Chang*, J. Fanara n, N. Kulkarni n, I. Ganguly n, S. Rollmann n, K. Kamdar*, T. Mackay n

MeSH headings : Animals; Biotransformation; Drosophila melanogaster / genetics; Epistasis, Genetic; Gene Expression Regulation; Odorants; Smell / physiology; Transcription, Genetic
TL;DR: Quantitative complementation tests of mutations at coregulated genes with the smi mutations showed that in most cases (67%) epistatic interactions for olfactory behavior mirrored epistasis at the level of transcription, thus identifying new candidate genes regulating olfaction behavior. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC)

Genetics, 163(2), 637–645.

By: T. Borras, T. Morozova, S. Heinsohn, R. Lyman, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Association of single-nucleotide polymorphisms at the Delta locus with genotype by environment interaction for sensory bristle number in Drosophila melanogaster

GENETICS RESEARCH, 79(3), 211–218.

MeSH headings : Abdomen / physiology; Animals; Drosophila melanogaster / genetics; Environment; Genetic Variation; Genotype; Intracellular Signaling Peptides and Proteins; Membrane Proteins / genetics; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable; Sense Organs / physiology
TL;DR: Heterozygotes for the abdominal bristle number SNPs were indeed the most stable genotype for two of the three environment pairs exhibiting GEI, but the mean genotypic effect was greater than the standard deviation of effects across environments, so this mechanism of GEI seems unlikely to be responsible for maintaining the common bristle numbers at Dl. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2002 review

Enabling population and quantitative genomics

[Review of ]. GENETICS RESEARCH, 80(1), 1–6.

By: G. Gibson n & T. Mackay

MeSH headings : Animals; Drosophila melanogaster / genetics; Genetics, Population; Genomics
TL;DR: The set of community-wide genetic and molecular resources, including panels of specific types of inbred lines and high density resequencing and SNP detection, that will facilitate studies of quantitative traits to the nucleotide level are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Novel loci control variation in reproductive timing in Arabidopsis thaliana in natural environments

Genetics, 162(4), 1875–1884.

By: C. Weinig, M. Ungerer, L. Dorn, N. Kane, Y. Toyonaga, S. Halldorsdottir, T. Mackay, M. Purugganan, J. Schmitt

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Quantitative trait loci for inflorescence development in Arabidopsis thaliana

Genetics, 160(3), 1133–1151.

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

The DSC1 channel, encoded by the smi60E locus, contributes to odor-guided behavior in Drosophila melanogaster

Genetics, 161(4), 1507–1516.

By: N. Kulkarni, A. Yamamoto, K. Robinson, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

The complex genetic architecture of Drosophila life span

EXPERIMENTAL AGING RESEARCH, 28(4), 361–390.

MeSH headings : Animals; Chimera; Crosses, Genetic; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Female; Genetic Variation; Genotype; Longevity / genetics; Male; Quantitative Trait Loci; Sexual Behavior, Animal
TL;DR: All of the QTL mapping data for Drosophila life span is summarized, the additive allelic effects and dominance of QTL were highly sex-specific, and future prospects for disentangling the genetic and environmental influences on this trait are outlined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

The genetic architecture of drosophila sensory bristle number

Genetics, 162(4), 1655–1674.

By: C. Dilda & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

The hairy: A quantitative trait locus for Drosophila sensory bristle number

Genetics, 162(1), 155–164.

By: C. Robin, R. Lyman, A. Long, C. Langley & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

The nature of quantitative genetic variation for Drosophila longevity

Mechanisms of Ageing and Development, 123(2-3), 95–104.

By: T. MacKay n

MeSH headings : Animals; Chromosome Mapping; Drosophila melanogaster / genetics; Female; Genetic Variation; Humans; Linkage Disequilibrium; Longevity / genetics; Male; Quantitative Trait, Heritable
TL;DR: In the future, linkage disequilibrium mapping can be used to determine which candidate genes in a QTL region correspond to the genetic loci affecting variation in life span, and define the QTL alleles at the molecular level. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior

Genetics, 162(3), 1321–1328.

By: J. Fanara, K. Robinson, S. Rollmann, R. Anholt & T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Variation in Drosophila sensory bristle number at 'Evolution Canyon'

GENETICS RESEARCH, 80(3), 215–223.

MeSH headings : Animals; Drosophila / anatomy & histology; Drosophila / genetics; Female; Genetic Variation; Male
TL;DR: The pattern of genetic variation between sites was consistent with underlying heterogeneity of genetic mechanisms for response to the same environmental gradients between traits and sibling species, and the genetic architecture of bristle number at the level of variation within populations was very similar between species for the same bristle trait. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Functional genomics of odor-guided behavior in Drosophila melanogaster

CHEMICAL SENSES, 26(2), 215–221.

By: R. Anholt n, J. Fanara, G. Fedorowicz, I. Ganguly, N. Kulkarni, T. Mackay, S. Rollmann

MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Genes, Insect; Models, Biological; Mutagenesis, Insertional; Mutation; Odorants; Smell / genetics; Smell / physiology
TL;DR: The identification and functional characterization of proteins encoded by smi genes that form part of the olfactory subgenome and correlation of polymorphisms in these genes with variation in odor-guided behavior in natural populations will advance the understanding of the genetic architecture of chemosensory behavior. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2001 review

Quantitative trait loci in Drosophila

[Review of ]. NATURE REVIEWS GENETICS, 2(1), 11–20.

By: T. Mackay

MeSH headings : Animals; Chromosome Mapping; Drosophila melanogaster / genetics; Female; Humans; Linkage Disequilibrium; Male; Mutagenesis; Quantitative Trait, Heritable
TL;DR: Drosophila quantitative trait loci have sex-, environment- and genotype-specific effects, and are often associated with molecular polymorphisms in non-coding regions of candidate genes, and offer valuable lessons to those seeking to understand quantitative traits in other organisms, including humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Quantitative trait locus mapping of fitness-related traits in Drosophila melanogaster

GENETICAL RESEARCH, 77(1), 107–116.

MeSH headings : Analysis of Variance; Animals; Body Constitution / genetics; Chromosome Mapping; DNA Transposable Elements; Drosophila melanogaster / genetics; Environment; Female; Fertility / genetics; Genetic Markers; Genetic Variation; Genotype; Inbreeding; Male; Quantitative Trait, Heritable; Recombination, Genetic; Sex Factors; Time Factors
TL;DR: There was significant genetic variation segregating in this cross for ovariole number, but not for body size or early fecundity, and Quantitative trait loci affecting female reproductive success and ovarioel number were mapped using a composite interval mapping procedure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

The genetic architecture of odor-guided behavior in Drosophila melanogaster

BEHAVIOR GENETICS, 31(1), 17–27.

author keywords: olfaction; chemoreception; quantitative genetics; P-element insertional mutagenesis; epistasis; functional genomics
MeSH headings : Animals; Avoidance Learning / physiology; DNA Transposable Elements / genetics; Drosophila melanogaster / genetics; Female; Genotype; Male; Models, Genetic; Mutagenesis, Insertional / genetics; Phenotype; Smell / genetics
TL;DR: The identification and functional characterization of proteins encoded by smi genes that form part of the olfactory subgenome and correlation of polymorphisms in these genes with variation in odor-guided behavior in natural populations will advance the understanding of the genetic architecture of chemosensory behavior. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 review

The genetic architecture of quantitative traits

[Review of ]. ANNUAL REVIEW OF GENETICS, 35, 303–339.

By: T. Mackay n

author keywords: quantitative trait loci (QTL); quantitative trait nucleotides (QTN); QTL mapping; linkage disequilibrium mapping; single nucleotide polymorphisms (SNPs)
MeSH headings : Animals; Chromosome Mapping; Genetic Linkage; Genotype; Humans; Models, Genetic; Mutation; Polymorphism, Single Nucleotide / genetics; Quantitative Trait, Heritable
TL;DR: Complete genome sequences and improved technologies for polymorphism detection will greatly advance the genetic dissection of quantitative traits in model organisms, which will open avenues for exploration of homologous QTL in related taxa. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Both naturally occurring insertions of transposable elements and intermediate frequency polymorphisms at the achaete-scute complex are associated with variation in bristle number in Drosophila melanogaster

Genetics, 154(3), 1255–1269.

By: A. Long, R. Lyman, A. Morgan, C. Langley & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Deficiency mapping of quantitative trait loci affecting longevity in Drosophila melanogaster

Genetics, 156(3), 1129–1146.

By: E. Pasyukova, C. Vieira & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Genotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster

Genetics, 154(1), 213–227.

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Quantitative trait loci for floral morphology in Arabidopsis thaliana

Genetics, 156(3), 1379–1392.

By: T. Juenger, M. Purugganan & T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Quantitative trait loci for life span in Drosophila melanogaster: Interactions with genetic background and larval density

Genetics, 155(4), 1773–1788.

By: J. Leips & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

High-resolution mapping of quantitative trait loci for sternopleural bristle number in Drosophila melanogaster

Genetics, 152(4), 1585–1604.

By: M. Gurganus, S. Nuzhdin, J. Leips & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Linkage disequilibrium mapping of molecular polymorphisms at the scabrous locus associated with naturally occurring variation in bristle number in Drosophila melanogaster

GENETICS RESEARCH, 74(3), 303–311.

By: R. Lyman n, C. Lai n & T. Mackay n

MeSH headings : Animals; Chromosome Mapping; Drosophila Proteins; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Female; Glycoproteins / genetics; Insect Proteins / genetics; Linkage Disequilibrium; Male; Phenotype; Polymorphism, Genetic; Quantitative Trait, Heritable
TL;DR: Three sites in regulatory regions were associated with female-specific variation in abdominal bristle number, one of which was an SSCP site in the region of the gene associated with regulation of sca in embryonic abdominal segments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

The genetic architecture of selection response: Inferences from fine-scale mapping of bristle number quantitative trait loci in Drosophila melanogaster

Genetics, 153(3), 1317–1331.

By: S. Nuzhdin, C. Dilda & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Candidate quantitative trait loci and naturally occurring phenotypic variation for bristle number in Drosophila melanogaster: The Delta-Hairless gene region

Genetics, 149(2), 983–998.

By: R. Lyman & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Epistatic interactions between smell-impaired loci in Drosophila melanogaster

Genetics, 148(4), 1885–1891.

By: G. Fedorowicz, J. Fry, R. Anholt & T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Genotype-environment interaction at quantitative trait loci affecting sensory bristle number in Drosophila melanogaster

Genetics, 149(4), 1883–1898.

By: M. Gurganus, J. Fry, S. Nuzhdin, E. Pasyukova, R. Lyman & T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Heterosis for viability, fecundity, and male fertility in Drosophila melanogaster: Comparison of mutational and standing variation

Genetics, 148(3), 1171–1188.

By: J. Fry, S. Heinsohn & T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Pervasive effects of P element mutagenesis on body size in Drosophila melanogaster

GENETICS RESEARCH, 72(1), 19–24.

By: D. Currie*, T. Mackay n & L. Partridge*

MeSH headings : Animals; Body Constitution / genetics; DNA Transposable Elements / genetics; DNA Transposable Elements / physiology; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Gene Expression Regulation; Male; Mutagenesis, Insertional
TL;DR: Insertional mutagenesis is potentially a powerful tool for investigating the genes involved in size-control in Drosophila, but the technique requires fine tuning for use on polygenic and fitness-related traits. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Quantitative genetics of ovariole number in Drosophila melanogaster. II. Mutational variation and genotype-environment interaction

Genetics, 148(1), 201–210.

By: M. Wayne & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Quemao, a Drosophila bristle locus, encodes geranylgeranyl pyrophosphate synthase

Genetics, 149(2), 1051–1061.

By: C. Lai, R. McMahon, C. Young, T. Mackay & C. Langley

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

The mutation rates of di-, tri- and tetranucleotide repeats in Drosophila melanogaster

MOLECULAR BIOLOGY AND EVOLUTION, 15(12), 1751–1760.

By: M. Schug n, C. Hutter n, K. Wetterstrand n, M. Gaudette n, T. Mackay n & C. Aquadro n

author keywords: Drosophila melanogaster; microsatellite; simple sequence length polymorphism; SSR; mutation rate; effective population size
MeSH headings : Africa; Alleles; Animals; Dinucleotide Repeats; Drosophila melanogaster / genetics; Evolution, Molecular; Female; Gene Library; Genetic Markers; Heterozygote; Microsatellite Repeats; Models, Genetic; Mutation; Polymerase Chain Reaction; Regression Analysis; Time; Trinucleotide Repeats; United States
TL;DR: A positive correlation between repeat unit length and allelic variation suggests that mutation rate increases as the repeat unit lengths of microsatellites increase, and this work estimated the relative difference in microsatellite mutation rate among di-, tri-, and tetranucleotide repeats in the genome of D. melanogaster using a method based on population variation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in Drosophila melanogaster

Genetics, 149(2), 999–1017.

By: A. Long, R. Lyman, C. Langley & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

1997 article

Accumulation of transposable elements in laboratory lines of Drosophila melanogaster

GENETICA, Vol. 100, pp. 167–175.

By: S. Nuzhdin n, E. Pasyukova* & T. Mackay n

TL;DR: Inferences about the properties of spontaneous mutations from studies of mutation accumulation in laboratory lines should be reevaluated, because they are based on the assumption of a constant mutation rate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Genetic and molecular analysis of smooth, a quantitative trait locus affecting bristle number in Drosophila melanogaster

Genetics, 146(2), 607–618.

By: P. Lage, A. Shrimpton, A. Flavell, T. Mackay & A. Brown

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Low mutation rates of microsatellite loci in Drosophila melanogaster

NATURE GENETICS, 15(1), 99–102.

By: M. Schug*, T. Mackay n & C. Aquadro*

MeSH headings : Animals; Drosophila melanogaster / genetics; Humans; Microsatellite Repeats / genetics; Molecular Sequence Data; Mutation
TL;DR: It is proposed that the comparatively low mutation rate is primarily a function of short microsatellite repeat lengths in the D. melanogaster genome, which is considerably lower than reported for various mammals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Quantitative genetics of ovariole number in Drosophila melanogaster. I. Segregating variation and fitness

Evolution, 51(4), 1156–1163.

By: M. Wayne*, J. Hackett* & T. Mackay

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
13. Climate Action (Web of Science)
Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 94(18), 9734–9739.

By: S. Nuzhdin n, E. Pasyukova n, C. Dilda n, Z. Zeng n & T. Mackay n

MeSH headings : Animals; Drosophila melanogaster / genetics; Female; Genes, Insect; Longevity / genetics; Male; Mutation; Sex Determination Analysis
TL;DR: Late age-of-onset QTL effects are consistent with the mutation accumulation hypothesis for the evolution of senescence, and sex-specificQTL effects suggest a novel mechanism for maintaining genetic variation for lifespan. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

The contribution of new mutations to genotype-environment interaction for fitness in Drosophila melanogaster

Evolution, 50(6), 2316–2327.

By: J. Fry*, S. Heinsohn* & T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

1996 review

The nature of quantitative genetic variation revisited: Lessons from Drosophila bristles

[Review of ]. BIOESSAYS, 18(2), 113–121.

By: T. Mackay n

MeSH headings : Animals; Chromosome Mapping; Drosophila melanogaster / genetics; Genetic Variation; Mutation
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1995 journal article

THE GENETIC-BASIS OF QUANTITATIVE VARIATION - NUMBERS OF SENSORY BRISTLES OF DROSOPHILA-MELANOGASTER AS A MODEL SYSTEM

TRENDS IN GENETICS, 11(12), 464–470.

MeSH headings : Animals; Crosses, Genetic; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Female; Genes, Insect; Genetic Variation; Male; Models, Genetic; Mutagenesis, Insertional; Mutation
TL;DR: The numbers of sensory hairs of Drosophila melanogaster present an ideal model system to elucidate the genetic basis of morphological quantitative variation and much of the mutational and segregating variation affecting bristle number is attributable to alleles with large phenotype effects at a small number of candidate loci. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

journal article

A drosophila model for toxicogenomics: Genetic variation in susceptibility to heavy metal exposure

Zhou, S. S., Luoma, S. E., Armour, G. E. S., Thakkar, E., Mackay, T. F. C., & Anholt, R. R. H. PLoS Genetics, 13(7).

By: S. Zhou, S. Luoma, G. Armour, E. Thakkar, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

A transcriptional network associated with natural variation in Drosophila aggressive behavior

Edwards, A. C., Ayroles, J. F., Stone, E. A., Carbone, M. A., Lyman, R. F., & Mackay, T. F. C. Genome Biology, 10(7).

By: A. Edwards, J. Ayroles, E. Stone, M. Carbone, R. Lyman & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

A-maize-ing diversity

Mackay, T. F. C. Science, 325(5941), 688–689.

By: T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Accounting for genetic architecture improves sequence based genomic prediction for a Drosophila fitness trait

Ober, U., Huang, W., Magwire, M., Schlather, M., Simianer, H., & Mackay, T. F. C. PLoS One, 10(5).

By: U. Ober, W. Huang, M. Magwire, M. Schlather, H. Simianer & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Alan Robertson (1920-1989)

Mackay, T. F. C. Genetics, 125(1), 1.

By: T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Analysis of natural variation reveals neurogenetic networks for Drosophila olfactory behavior

Swarup, S., Huang, W., Mackay, T. F. C., & Anholt, R. R. H. Proceedings of the National Academy of Sciences of the United States of America, 110(3), 1017–1022.

By: S. Swarup, W. Huang, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Anecdotal, historical and critical commentaries on genetics

Hill, W. G., & Mackay, T. F. C. Genetics, 167(4), 1529–1536.

By: W. Hill & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

review

Charting the genotype-phenotype map: Lessons from the Drosophila melanogaster genetic reference panel

Mackay, T. F. C., & Huang, W. [Review of ]. Wiley Interdisciplinary Reviews-Developmental Biology, 7(1).

By: T. Mackay & W. Huang

Source: NC State University Libraries
Added: August 6, 2018

journal article

Complex genetic architecture of Drosophila aggressive behavior

Zwarts, L., Magwire, M. M., Carbone, M. A., Versteven, M., Herteleer, L., Anholt, R. R. H., … Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 108(41), 17070–17075.

By: L. Zwarts, M. Magwire, M. Carbone, M. Versteven, L. Herteleer, R. Anholt, P. Callaerts, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

review

Douglas Scott Falconer (1913-2004)

MacKay, T. F. C. [Review of ]. Heredity, 93(2), 119–121.

By: T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

review

Epistasis and quantitative traits: using model organisms to study gene-gene interactions

Mackay, T. F. C. [Review of ]. Nature Reviews. Genetics, 15(1), 22–33.

By: T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Epistasis dominates the genetic architecture of Drosophila quantitative traits

Huang, W., Richards, S., Carbone, M. A., Zhu, D. H., Anholt, R. R. H., Ayroles, J. F., … Muzny, D. Proceedings of the National Academy of Sciences of the United States of America, 109(39), 15553–15559.

By: W. Huang, S. Richards, M. Carbone, D. Zhu, R. Anholt, J. Ayroles, L. Duncan, K. Jordan ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Epistasis for quantitative traits in Drosophila

Mackay, T. F. C. Epistasis: Methods and Protocols, 1253, 47–70.

By: T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Epistatic interactions attenuate mutations affecting startle behaviour in Drosophila melanogaster

Yamamoto, A., Anholt, R. R. H., & Mackay, T. F. C. Genetical Research, 91(6), 373–382.

By: A. Yamamoto, R. Anholt & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Evaluation of artificial selection in Standard Poodles using whole-genome sequencing

Friedenberg, S. G., Meurs, K. M., & Mackay, T. F. C. Mammalian Genome, 27(11-12), 599–609.

By: S. Friedenberg, K. Meurs & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

review

Finding the missing heritability of complex diseases

Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., … Rotimi, C. N. [Review of ]. Nature, 461(7265), 747–753.

By: T. Manolio, F. Collins, N. Cox, D. Goldstein, L. Hindorff, D. Hunter, M. McCarthy, E. Ramos ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Functional genome annotation of Drosophila seminal fluid proteins using transcriptional genetic networks

Ayroles, J. F., Laflamme, B. A., Stone, E. A., Wolfner, M. F., & Mackay, T. F. C. Genetical Research, 93(6), 387–395.

By: J. Ayroles, B. Laflamme, E. Stone, M. Wolfner & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Functional validation of candidate genes detected by genomic feature models

Rohde, P. D., Ostergaard, S., Kristensen, T. N., Sorensen, P., Loeschcke, V., Mackay, T. F. C., & Sarup, P. G3-Genes Genomes Genetics, 8(5), 1659–1668.

By: P. Rohde, S. Ostergaard, T. Kristensen, P. Sorensen, V. Loeschcke, T. Mackay, P. Sarup

Source: NC State University Libraries
Added: August 6, 2018

journal article

Functional validation of candidate genes detected by genomic feature models

Rohde, P. D., Ostergaard, S., Kristensen, T. N., Sorensen, P., Loeschcke, V., Mackay, T. F. C., & Sarup, P. G3-Genes Genomes Genetics, 8(5), 1659–1668.

By: P. Rohde, S. Ostergaard, T. Kristensen, P. Sorensen, V. Loeschcke, T. Mackay, P. Sarup

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic and genomic response to selection for food consumption in Drosophila melanogaster

Garlapow, M. E., Everett, L. J., Zhou, S. S., Gearhart, A. W., Fay, K. A., Huang, W., … Mackay, T. F. C. Behavior Genetics, 47(2), 227–243.

By: M. Garlapow, L. Everett, S. Zhou, A. Gearhart, K. Fay, W. Huang, T. Morozova, G. Arya ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic architecture of abdominal pigmentation in Drosophila melanogaster

Dembeck, L. M., Huang, W., Magwire, M. M., Lawrence, F., Lyman, R. F., & Mackay, T. F. C. PLoS Genetics, 11(5).

By: L. Dembeck, W. Huang, M. Magwire, F. Lawrence, R. Lyman & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic architecture of natural variation in Drosophila melanogaster aggressive behavior

Shorter, J., Couch, C., Huang, W., Carbone, M. A., Peiffer, J., Anholt, R. R. H., & Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 112(27), E3555–3563.

By: J. Shorter, C. Couch, W. Huang, M. Carbone, J. Peiffer, R. Anholt, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster

Dembeck, L. M., Boroczky, K., Huang, W., Schal, C., Anholt, R. R. H., & Mackay, T. F. C. Elife, 4.

By: L. Dembeck, K. Boroczky, W. Huang, C. Schal, R. Anholt & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic architecture of natural variation in visual senescence in Drosophila

Carbone, M. A., Yamamoto, A., Huang, W., Lyman, R. A., Meadors, T. B., Yamamoto, R., … Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 113(43), E6620–6629.

By: M. Carbone, A. Yamamoto, W. Huang, R. Lyman, T. Meadors, R. Yamamoto, R. Anholt, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

review

Genetic architecture of quantitative traits in mice, flies, and humans

Flint, J., & Mackay, T. F. C. [Review of ]. Genome Research, 19(5), 723–733.

By: J. Flint & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic basis of natural variation in body pigmentation in Drosophila melanogaster

Dembeck, L. M., Huang, W., Carbone, M. A., & Mackay, T. F. C. Fly, 9(2), 75–81.

By: L. Dembeck, W. Huang, M. Carbone & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic basis of transcriptome diversity in Drosophila melanogaster

Huang, W., Carbone, M. A., Magwire, M. M., Peiffer, J. A., Lyman, R. F., Stone, E. A., … Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 112(44), E6010–6019.

By: W. Huang, M. Carbone, M. Magwire, J. Peiffer, R. Lyman, E. Stone, R. Anholt, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic control of environmental variation of two quantitative traits of Drosophila melanogaster revealed by whole-genome sequencing

Sorensen, P., Campos, G., Morgante, F., Mackay, T. F. C., & Sorensen, D. Genetics, 201(2), 487-.

By: P. Sorensen, G. Campos, F. Morgante, T. Mackay & D. Sorensen

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic mapping uncovers cis-regulatory landscape of RNA editing

Ramaswami, G., Deng, P., Zhang, R., Carbone, M. A., Mackay, T. F. C., & Li, J. B. Nature Communications, 6.

By: G. Ramaswami, P. Deng, R. Zhang, M. Carbone, T. Mackay & J. Li

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic variation in senescence marker protein-30 is associated with natural variation in cold tolerance in Drosophila

Clowers, K. J., Lyman, R. F., Mackay, T. F. C., & Morgan, T. J. Genetical Research, 92(2), 103–113.

By: K. Clowers, R. Lyman, T. Mackay & T. Morgan

Source: NC State University Libraries
Added: August 6, 2018

review

Genetics and genomics of alcohol sensitivity

Morozova, T. V., Mackay, T. F. C., & Anholt, R. R. H. [Review of ]. Molecular Genetics and Genomics, 289(3), 253–269.

By: T. Morozova, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetics of alcohol consumption in Drosophila melanogaster

Fochler, S., Morozova, T. V., Davis, M. R., Gearhart, A. W., Huang, W., Mackay, T. F. C., & Anholt, R. R. H. Genes Brain and Behavior, 16(7), 675–685.

By: S. Fochler, T. Morozova, M. Davis, A. Gearhart, W. Huang, T. Mackay, R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide analysis reveals novel regulators of growth in Drosophila melanogaster

Vonesch, S. C., Lamparter, D., Mackay, T. F. C., Bergmann, S., & Hafen, E. PLoS Genetics, 12(1).

By: S. Vonesch, D. Lamparter, T. Mackay, S. Bergmann & E. Hafen

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster

Weber, A. L., Khan, G. F., Magwire, M. M., Tabor, C. L., Mackay, T. F. C., & Anholt, R. R. H. PLoS One, 7(4).

By: A. Weber, G. Khan, M. Magwire, C. Tabor, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide association analysis of tolerance to methylmercury toxicity in Drosophila implicates myogenic and neuromuscular developmental pathways

Montgomery, S. L., Vorojeikina, D., Huang, W., Mackay, T. F. C., Anholt, R. R. H., & Rand, M. D. PLoS One, 9(10).

By: S. Montgomery, D. Vorojeikina, W. Huang, T. Mackay, R. Anholt & M. Rand

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide association for sensitivity to chronic oxidative stress in Drosophila melanogaster

Jordan, K. W., Craver, K. L., Magwire, M. M., Cubilla, C. E., Mackay, T. F. C., & Anholt, R. R. H. PLoS One, 7(6).

By: K. Jordan, K. Craver, M. Magwire, C. Cubilla, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genomic analysis of genotype-by-social environment interaction for Drosophila melanogaster aggressive behavior

Rohde, P. D., Gaertner, B., Ward, K., Sorensen, P., & Mackay, T. F. C. Genetics, 206(4), 1969–1984.

By: P. Rohde, B. Gaertner, K. Ward, P. Sorensen & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genomic prediction for quantitative traits is improved by mapping variants to gene ontology categories in Drosophila melanogaster

Edwards, S. M., Sorensen, I. F., Sarup, P., Mackay, T. F. C., & Sorensen, P. Genetics, 203(4), 1871-.

By: S. Edwards, I. Sorensen, P. Sarup, T. Mackay & P. Sorensen

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genomic response to selection for postponed senescence in Drosophila

Wilson, R. H., Lai, C. Q., Lyman, R. F., & Mackay, T. F. C. Mechanisms of Ageing and Development, 134(3-4), 79–88.

By: R. Wilson, C. Lai, R. Lyman & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genomic variation and its impact on gene expression in Drosophila melanogaster

Massouras, A., Waszak, S. M., Albarca-Aguilera, M., Hens, K., Holcombe, W., Ayroles, J. F., … Deplancke, B. PLoS Genetics, 8(11).

By: A. Massouras, S. Waszak, M. Albarca-Aguilera, K. Hens, W. Holcombe, J. Ayroles, E. Dermitzakis, E. Stone ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Heritable variation in courtship patterns in Drosophila melanogaster

Gaertner, B. E., Ruedi, E. A., McCoy, L. J., Moore, J. M., Wolfner, M. F., & Mackay, T. F. C. G3-Genes Genomes Genetics, 5(4), 531–539.

By: B. Gaertner, E. Ruedi, L. McCoy, J. Moore, M. Wolfner & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Intrapopulation genome size variation in D. melanogaster reflects life history variation and plasticity

Ellis, L. L., Huang, W., Quinn, A. M., Ahuja, A., Alfrejd, B., Gomez, F. E., … Tarone, A. M. PLoS Genetics, 10(7).

By: L. Ellis, W. Huang, A. Quinn, A. Ahuja, B. Alfrejd, F. Gomez, C. Hjelmen, K. Moore ...

Source: NC State University Libraries
Added: August 6, 2018

book

Introduction to quantitative genetics

Falconer, D. S., & Mackay, T. F. C. Essex, England: Longman.

By: D. Falconer & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Longevity GWAS using the Drosophila Genetic Reference Panel

Ivanov, D. K., Escott-Price, V., Ziehm, M., Magwire, M. M., Mackay, T. F. C., Partridge, L., & Thomton, J. M. Journals of Gerontology. Series A, Biological Sciences Medical Sciences, 70(12), 1470–1478.

By: D. Ivanov, V. Escott-Price, M. Ziehm, M. Magwire, T. Mackay, L. Partridge, J. Thomton

Source: NC State University Libraries
Added: August 6, 2018

review

Mutations and quantitative genetic variation: Lessons from Drosophila

Mackay, T. F. C. [Review of ]. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 365(1544), 1229–1239.

By: T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Natural variation in odorant recognition among odorant-binding proteins in Drosophila melanogaster

Wang, P., Lyman, R. F., Mackay, T. F. C., & Anholt, R. R. H. Genetics, 184(3), 759–767.

By: P. Wang, R. Lyman, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Natural variation, functional pleiotropy and transcriptional contexts of odorant binding protein genes in Drosophila melanogaster

Arya, G. H., Weber, A. L., Wang, P., Magwire, M. M., Negron, Y. L. S., Mackay, T. F. C., & Anholt, R. R. H. Genetics, 186(4), 1475–1623.

By: G. Arya, A. Weber, P. Wang, M. Magwire, Y. Negron, T. Mackay, R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogaster

Jumbo-Lucioni, P., Bu, S., Harbison, S. T., Slaughter, J. C., Mackay, T. F. C., Moellering, D. R., & De Luca, M. BMC Genomics, 13.

By: P. Jumbo-Lucioni, S. Bu, S. Harbison, J. Slaughter, T. Mackay, D. Moellering, M. De Luca

Source: NC State University Libraries
Added: August 6, 2018

journal article

Obp56h modulates mating behavior in Drosophila melanogaster

Shorter, J. R., Dembeck, L. M., Everett, L. J., Morozova, T. V., Arya, G. H., Turlapati, L., … Anholt, R. R. H. G3-Genes Genomes Genetics, 6(10), 3335–3342.

Source: NC State University Libraries
Added: August 6, 2018

journal article

Odorant receptor polymorphisms and natural variation in olfactory behavior in Drosophila melanogaster

Rollmann, S. M., Wang, P., Date, P., West, S. A., Mackay, T. F. C., & Anholt, R. R. H. Genetics, 186(2), 687–364.

By: S. Rollmann, P. Wang, P. Date, S. West, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

review

Of flies and man: Drosophila as a model for human complex traits

Mackay, T. E. C., & Anholt, R. R. H. [Review of ]. Annual Review of Genomics and Human Genetics, 7, 339–367.

By: T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: Implications for glaucoma

Carbone, M. A., Ayroles, J. F., Yamamoto, A., Morozova, T. V., West, S. A., Magwire, M. M., … Anholt, R. R. H. PLoS One, 4(1).

By: M. Carbone, J. Ayroles, A. Yamamoto, T. Morozova, S. West, M. Magwire, T. Mackay, R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster

Morozova, T. V., Anholt, R. R., & MacKay, T. F. Genome Biology, 8(10).

By: T. Morozova, R. Anholt & T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Plasticity of the chemoreceptor repertoire in Drosophila melanogaster

Zhou, S. S., Stone, E. A., Mackay, T. F. C., & Anholt, R. R. H. PLoS Genetics, 5(10).

By: S. Zhou, E. Stone, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Polygenic mutation in Drosophila melanogaster: Genotype x environment interaction for spontaneous mutations affecting bristle number

Mackay, T. F. C., & Lyman, R. F. Genetica, 102-103(1-6), 199–215.

By: T. Mackay & R. Lyman

Source: NC State University Libraries
Added: August 6, 2018

journal article

Polygenic mutation in Drosophila melanogaster: Non-linear divergence among unselected strains

Mackay, T. F. C., Lyman, R. F., & Hill, W. G. Genetics, 139(2), 849.

By: T. Mackay, R. Lyman & W. Hill

Source: NC State University Libraries
Added: August 6, 2018

journal article

Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila

Morozova, T. V., Huang, W., Pray, V. A., Whitham, T., Anholt, R. R. H., & Mackay, T. F. C. BMC Genomics, 16.

By: T. Morozova, W. Huang, V. Pray, T. Whitham, R. Anholt & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Q & A - Trudy Mackay

Mackay, T. Q & A - Trudy Mackay. Current Biology, 16(17), R659–661.

By: T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Quantitative and molecular genetic analyses of mutations increasing Drosophila life span

Magwire, M. M., Yamamoto, A., Carbone, M. A., Roshina, N. V., Symonenko, A. V., Pasyukova, E. G., … Mackay, T. F. C. PLoS Genetics, 6(7).

By: M. Magwire, A. Yamamoto, M. Carbone, N. Roshina, A. Symonenko, E. Pasyukova, T. Morozova, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Quantitative genetic variation of odor-guided behavior in a natural population of Drosophila melanogaster

Mackay, T. F. C., Hackett, J. B., Lyman, R. F., Wayne, M. L., & Anholt, R. R. H. Genetics, 144(2), 727.

By: T. Mackay, J. Hackett, R. Lyman, M. Wayne & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Quantitative genetics of food intake in Drosophila melanogaster

Garlapow, M. E., Huang, W., Yarboro, M. T., Peterson, K. R., & Mackay, T. F. C. PLoS One, 10(9).

By: M. Garlapow, W. Huang, M. Yarboro, K. Peterson & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Quantitative genomics of locomotor behavior in Drosophila melanogaster

Jordan, K. W., Carbone, M. A., Yamamoto, A., Morgan, T. J., & Mackay, T. F. Genome Biology, 8(8).

Source: NC State University Libraries
Added: August 6, 2018

journal article

Quantitative genomics of starvation stress resistance in Drosophila

Harbison, S. T., Chang, S., Kamdar, K. P., & MacKay, T. F. C. Genome Biology, 6(4).

By: S. Harbison, S. Chang, K. Kamdar & T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Quantitative trait locus mapping of gravitaxis behaviour in Drosophila melanogaster

Desroches, C. E., Busto, M., Riedl, C. A. L., Mackay, T. F. C., & Sokolowski, M. B. Genetical Research, 92(3), 167–174.

By: C. Desroches, M. Busto, C. Riedl, T. Mackay & M. Sokolowski

Source: NC State University Libraries
Added: August 6, 2018

journal article

Regulation of Drosophila lifespan by bellwether promoter alleles

Garcia, J. F., Carbone, M. A., Mackay, T. F. C., & Anholt, R. R. H. Scientific Reports, 7.

By: J. Garcia, M. Carbone, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Scribble is essential for olfactory behavior in Drosophila melanogaster

Ganguly, I., MacKay, T. F. C., & Anholt, R. R. H. Genetics, 164(4), 1447–1457.

By: I. Ganguly, T. MacKay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Spontaneous mutations and the origin and maintenance of quantitative genetic variation

Huang, W., Lyman, R. F., Lyman, R. A., Carbone, M. A., Harbison, S. T., Magwire, M. M., & Mackay, T. F. C. Elife, 5.

By: W. Huang, R. Lyman, R. Lyman, M. Carbone, S. Harbison, M. Magwire, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster

Jumbo-Lucioni, P., Ayroles, J. F., Chambers, M. M., Jordan, K. W., Leips, J., Mackay, T. F. C., … Luca, M. BMC Genomics, 11.

By: P. Jumbo-Lucioni, J. Ayroles, M. Chambers, K. Jordan, J. Leips, T. Mackay, De, M. Luca

Source: NC State University Libraries
Added: August 6, 2018

journal article

The Drosophila melanogaster genetic reference panel

Mackay, T. F. C., Richards, S., Stone, E. A., Barbadilla, A., Ayroles, J. F., Zhu, D. H., … Carbone, M. A. Nature, 482(7384), 173–178.

By: T. Mackay, S. Richards, E. Stone, A. Barbadilla, J. Ayroles, D. Zhu, S. Casillas, Y. Han ...

Source: NC State University Libraries
Added: August 6, 2018

conference paper

The Persuasive phish: examining the social psychological principles hidden in phishing emails

Zielinska, O., Welk, A., Mayhorn, C. B., & Murphy-Hill, E. Symposium and Bootcamp on the Science of Security, 126–126.

By: O. Zielinska, A. Welk, C. Mayhorn & E. Murphy-Hill

Source: NC State University Libraries
Added: August 6, 2018

journal article

The effects of royal jelly on fitness traits and gene expression in Drosophila melanogaster

Shorter, J. R., Geisz, M., Ozsoy, E., Magwire, M. M., Carbone, M. A., & Mackay, T. F. C. PLoS One, 10(7).

By: J. Shorter, M. Geisz, E. Ozsoy, M. Magwire, M. Carbone & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

review

The future of model organisms in human disease research

Aitman, T. J., Boone, C., Churchill, G. A., Hengartner, M. O., Mackay, T. F. C., & Stemple, D. L. [Review of ]. Nature Reviews. Genetics, 12(8), 575–582.

By: T. Aitman, C. Boone, G. Churchill, M. Hengartner, T. Mackay & D. Stemple

Source: NC State University Libraries
Added: August 6, 2018

conference paper

The genetic architecture of complex behaviors: Lessons from Drosophila

Mackay, T. F. C. Genetica, 136(2), 295–302.

By: T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

The genetic architecture of natural variation in recombination rate in Drosophila melanogaster

Hunter, C. M., Huang, W., Mackay, T. F. C., & Singh, N. D. PLoS Genetics, 12(4).

By: C. Hunter, W. Huang, T. Mackay & N. Singh

Source: NC State University Libraries
Added: August 6, 2018

journal article

The genetic basis for variation in olfactory behavior in Drosophila melanogaster

Arya, G. H., Magwire, M. M., Huang, W., Serrano-Negron, Y. L., Mackay, T. F. C., & Anholt, R. R. H. Chemical Senses, 40(4), 233–243.

By: G. Arya, M. Magwire, W. Huang, Y. Serrano-Negron, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

The genetic basis for variation in sensitivity to lead toxicity in Drosophila melanogaster

Zhou, S. S., Morozova, T. V., Hussain, Y. N., Luoma, S. E., McCoy, L., Yamamoto, A., … Anholt, R. R. H. Environmental Health Perspectives, 124(7), 1062–1070.

By: S. Zhou, T. Morozova, Y. Hussain, S. Luoma, L. McCoy, A. Yamamoto, T. Mackay, R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

review

The genetic basis of alcoholism: Multiple phenotypes, many genes, complex networks

Morozova, T. V., Goldman, D., Mackay, T. F. C., & Anholt, R. R. H. [Review of ]. Genome Biology, 13(2).

By: T. Morozova, D. Goldman, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

The genetic basis of natural variation in mushroom body size in Drosophila melanogaster

Zwarts, L., Vanden Broeck, L., Cappuyns, E., Ayroles, J. F., Magwire, M. M., Vulsteke, V., … Callaerts, P. Nature Communications, 6.

By: L. Zwarts, L. Vanden Broeck, E. Cappuyns, J. Ayroles, M. Magwire, V. Vulsteke, J. Clements, T. Mackay, P. Callaerts

Source: NC State University Libraries
Added: August 6, 2018

review

The genetics of quantitative traits: Challenges and prospects

Mackay, T. F. C., Stone, E. A., & Ayroles, J. F. [Review of ]. Nature Reviews. Genetics, 10(8), 565–577.

By: T. Mackay, E. Stone & J. Ayroles

Source: NC State University Libraries
Added: August 6, 2018

journal article

The genomic basis of postponed senescence in Drosophila melanogaster

Carnes, M. U., Campbell, T., Huang, W., Butler, D. G., Carbone, M. A., Duncan, L. H., … Mackay, T. F. C. PLoS One, 10(9).

By: M. Carnes, T. Campbell, W. Huang, D. Butler, M. Carbone, L. Duncan, S. Harbajan, E. King ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

The road less traveled: from genotype to phenotype in flies and humans

Anholt, R. R. H., & Mackay, T. F. C. Mammalian Genome, 29(1-2), 5–23.

By: R. Anholt & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Transcriptional networks for alcohol sensitivity in drosophila melanogaster

Morozova, T. V., Mackay, T. F. C., & Anholt, R. R. H. Genetics, 187(4), 1193–1345.

By: T. Morozova, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Transcriptional response to alcohol exposure in Drosophila melanogaster

Morozova, T. V., Anholt, R. R. H., & MacKay, T. F. C. Genome Biology, 7(10).

By: T. Morozova, R. Anholt & T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Tuning the chemosensory window A fly's perspective

Zhou, S. S., Mackay, T. F. C., & Anholt, R. R. H. Fly, 4(3), 230–235.

By: S. Zhou, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

review

Understanding the neurogenetics of sleep: Progress from Drosophila

Harbison, S. T., Mackay, T. F. C., & Anholt, R. R. H. [Review of ]. Trends in Genetics, 25(6), 262–269.

By: S. Harbison, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Using whole-genome sequence data to predict quantitative trait phenotypes in Drosophila melanogaster

Ober, U., Ayroles, J. F., Stone, E. A., Richards, S., Zhu, D. H., Gibbs, R. A., … Simianer, H. PLoS Genetics, 8(5).

By: U. Ober, J. Ayroles, E. Stone, S. Richards, D. Zhu, R. Gibbs, C. Stricker, D. Gianola ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Why epistasis is important for tackling complex human disease genetics

Mackay, T. F. C., & Moore, J. H. Genome Medicine, 6.

By: T. Mackay & J. Moore

Source: NC State University Libraries
Added: August 6, 2018

article

Why epistasis is important for tackling complex human disease genetics (vol 6, 124, 2014)

Mackay, T. F. C., & Moore, J. H. Genome Medicine, Vol. 7.

By: T. Mackay & J. Moore

Source: NC State University Libraries
Added: August 6, 2018

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