Works (26)

Updated: August 13th, 2023 21:17

2023 journal article

LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 11.

By: M. Simmers n, D. Jima n, Y. Tsuji n & M. Cowley n

author keywords: lncRNA; Tuna; placental insufficiency; fetal growth restriction (FGR); Cadmium; Nrf2; oxidative stress
Sources: Web Of Science, ORCID
Added: July 3, 2023

2022 article

Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction

Simmers, M. D., Hudson, K. M., Baptissart, M., & Cowley, M. (2022, July 1). EPIGENETICS, Vol. 7.

By: M. Simmers n, K. Hudson n, M. Baptissart n & M. Cowley n

author keywords: Genomic imprinting; imprinted genes; DNA methylation; placenta; cadmium; foetal growth restriction; CDKN1C; toxic metal
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 article

Genomic map of candidate human imprint control regions: the imprintome

Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.

By: D. Jima n, D. Skaar n, A. Planchart n, A. Motsinger-Reif n, S. Cevik n, S. Park n, M. Cowley n, F. Wright n ...

author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 article

The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease

Riegl, S. D., Starnes, C., Jima, D. D., Baptissart, M., Diehl, A. M., Belcher, S. M., & Cowley, M. (2022, October 6). TOXICOLOGICAL SCIENCES, Vol. 10.

By: S. Riegl n, C. Starnes n, D. Jima n, M. Baptissart n, A. Diehl*, S. Belcher n, M. Cowley n

author keywords: nonalcoholic fatty liver disease; developmental toxicology; epigenetics; cadmium; genomic imprinting; developmental programming
MeSH headings : Mice; Animals; Non-alcoholic Fatty Liver Disease / genetics; Non-alcoholic Fatty Liver Disease / metabolism; Cadmium; Cadmium Chloride / toxicity; PPAR gamma; Liver / metabolism; Fibrosis
Sources: ORCID, Web Of Science
Added: October 29, 2022

2022 article

Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome

Baptissart, M., Bradish, C. M., Jones, B. S., Walsh, E., Tehrani, J., Marrero-Colon, V., … Cowley, M. (2022, February 28). HEPATOLOGY, Vol. 2.

By: M. Baptissart n, C. Bradish n, B. Jones n, E. Walsh n, J. Tehrani n, V. Marrero-Colon n, S. Mehta n, D. Jima n ...

MeSH headings : Animals; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Disease Models, Animal; Gene Regulatory Networks / genetics; Gene Regulatory Networks / physiology; Genes, Tumor Suppressor / physiology; Metabolic Syndrome / complications; Metabolic Syndrome / genetics; Metabolic Syndrome / metabolism; Mice; Non-alcoholic Fatty Liver Disease / complications; Non-alcoholic Fatty Liver Disease / genetics; Non-alcoholic Fatty Liver Disease / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism; Transforming Growth Factor beta1
Sources: Web Of Science, ORCID
Added: March 28, 2022

2021 journal article

Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 9.

By: A. Prickett*, B. Montibus*, N. Barkas*, S. Amante*, M. Franco*, M. Cowley*, W. Puszyk*, M. Shannon* ...

author keywords: dopa decarboxylase; knock-out; imprinting; heart; mouse; human
Sources: Web Of Science, ORCID
Added: July 12, 2021

2021 journal article

Transcriptomic, proteomic, and metabolomic analyses identify candidate pathways linking maternal cadmium exposure to altered neurodevelopment and behavior

SCIENTIFIC REPORTS, 11(1).

By: K. Hudson n, E. Shiver n, J. Yu*, S. Mehta n, D. Jima n, M. Kane*, H. Patisaul n, M. Cowley n

MeSH headings : Animals; Body Weight / drug effects; Body Weight / genetics; Cadmium / toxicity; Female; Fetal Development / drug effects; Fetal Development / genetics; Humans; Maternal Exposure; Metabolomics / methods; Mice; Mice, Inbred C57BL; Neurodevelopmental Disorders / chemically induced; Neurodevelopmental Disorders / genetics; Placenta / drug effects; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Proteomics / methods; Transcriptome / genetics
Sources: Web Of Science, ORCID
Added: August 30, 2021

2020 journal article

Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing

NUCLEIC ACIDS RESEARCH, 48(15), 8349–8359.

By: S. Amante*, B. Montibus*, M. Cowley*, N. Barkas*, J. Setiadi*, H. Saadeh*, J. Giemza*, S. Contreras-Castillo* ...

MeSH headings : Animals; Cell Differentiation / genetics; Chromatin / genetics; CpG Islands / genetics; DNA Methylation / genetics; Epigenesis, Genetic; Genome / genetics; Histone Code / genetics; Humans; Promoter Regions, Genetic; Protein Processing, Post-Translational / genetics; Pseudogenes / genetics; RNA Precursors / genetics; RNA Precursors / metabolism; Transcription, Genetic
Sources: Web Of Science, ORCID
Added: October 19, 2020

2019 journal article

Maternal cadmium exposure in the mouse leads to increased heart weight at birth and programs susceptibility to hypertension in adulthood

SCIENTIFIC REPORTS, 9(1).

By: K. Hudson n, S. Belcher n & M. Cowley n

MeSH headings : Animals; Animals, Newborn; Body Weight / drug effects; Cadmium / adverse effects; Disease Models, Animal; Female; Gene Expression Profiling / methods; Gene Expression Regulation / drug effects; Gene Regulatory Networks / drug effects; Heart / anatomy & histology; Heart / drug effects; Hypotension / chemically induced; Hypotension / genetics; Maternal Exposure / adverse effects; Metabolic Networks and Pathways / drug effects; Mice; Organ Size / drug effects; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Sequence Analysis, RNA
Sources: Web Of Science, ORCID
Added: October 7, 2019

2019 journal article

Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study

EPIGENETICS, 14(4), 325–340.

By: C. Martin*, D. Jima n, G. Sharp*, L. McCullough*, S. Park n, K. Gowdy*, D. Skaar n, M. Cowley n ...

author keywords: DNA methylation; epigenome-wide association study; maternal obesity; offspring body mass index; offspring blood pressure; cardiometabolic health; ALSPAC; NEST
MeSH headings : Adult; Blood Pressure; Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / genetics; Child; Child, Preschool; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Genome-Wide Association Study; Humans; Infant, Newborn / blood; Infant, Newborn / growth & development; Male; Membrane Transport Proteins / genetics; Metabolic Syndrome / epidemiology; Metabolic Syndrome / genetics; Obesity / epidemiology; Obesity / genetics
Sources: Web Of Science, ORCID
Added: April 29, 2019

2018 journal article

Effects of Cadmium Exposure on DNA Methylation at Imprinting Control Regions and Genome-Wide in Mothers and Newborn Children.

Environmental Health Perspectives, 3(3).

By: M. Cowley n, D. Skaar n, D. Jima n, R. Maguire n, K. Hudson n, S. Park n, P. Sorrow n, C. Hoyo n

MeSH headings : Cadmium / toxicity; DNA Methylation / drug effects; DNA Methylation / genetics; Epigenesis, Genetic / drug effects; Epigenesis, Genetic / ethics; Female; Genomic Imprinting / drug effects; Genomic Imprinting / genetics; Humans; Infant, Newborn; Male; Mothers
Sources: ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam

Proceedings of the Royal Society B: Biological Sciences, 285(1891), 20181237.

By: M. Baptissart n, H. Lamb n, K. To n, C. Bradish n, J. Tehrani n, D. Reif n, M. Cowley n

MeSH headings : Animals; Animals, Newborn / physiology; Diet, High-Fat; Female; Maternal Behavior / physiology; Maternal Exposure; Mice / physiology; Mice, Inbred C57BL; Pregnancy
Sources: NC State University Libraries, ORCID
Added: December 10, 2018

2016 review

Regulatory links between imprinted genes: Evolutionary predictions and consequences

By: M. Patten, M. Cowley, R. Oakey & R. Feil

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Regulatory links between imprinted genes: evolutionary predictions and consequences.

By: M. Patten*, M. Cowley n, R. Oakey* & R. Feil*

author keywords: evolution; genomic imprinting; gene network; trans regulation
MeSH headings : Animals; Biological Evolution; Gene Regulatory Networks; Genomic Imprinting; Mammals / genetics
Source: ORCID
Added: September 28, 2022

2015 article

Coadaptation between Mother and Offspring: Why Not?

Wolf, J. B., Cowley, M., & Ward, A. (2015, March). PLOS BIOLOGY, Vol. 13.

By: J. Wolf*, M. Cowley n & A. Ward*

MeSH headings : Animals; Body Size / genetics; Female; GRB10 Adaptor Protein / genetics
Sources: ORCID, Web Of Science
Added: August 6, 2018

2014 journal article

Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1 genes.

BMC Biology, 12, 771,

By: M. Madon-Simon*, M. Cowley n, A. Garfield*, K. Moorwood* & A. Ward*

author keywords: Adiposity; Body proportions; Genomic imprinting; Glucose-regulated metabolism; Growth; Mouse genetics
MeSH headings : Absorptiometry, Photon; Adipose Tissue / metabolism; Animals; Calcium-Binding Proteins; Cell Proliferation; Female; Fetal Development / genetics; Fibroblasts / metabolism; G2 Phase; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; Genomic Imprinting; Glucose Tolerance Test; History, Ancient; Insulin-Like Growth Factor II / genetics; Insulin-Like Growth Factor II / metabolism; Intercellular Signaling Peptides and Proteins / genetics; Intercellular Signaling Peptides and Proteins / metabolism; Liver / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; S Phase; Triglycerides / blood
Source: ORCID
Added: September 28, 2022

2014 journal article

Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup.

PLoS Biology, 12(2), 1001799,

MeSH headings : Animals; Body Size / genetics; Female; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; Gene Expression Regulation, Developmental; Genomic Imprinting; Karyopherins / physiology; Lactation / genetics; Mice; Mice, Knockout; Receptors, Cytoplasmic and Nuclear / physiology; STAT5 Transcription Factor / physiology
Source: ORCID
Added: September 28, 2022

2013 journal article

Transposable elements re-wire and fine-tune the transcriptome.

9(1), 1003234.

By: M. Cowley* & R. Oakey*

MeSH headings : DNA Transposable Elements / genetics; Evolution, Molecular; Gene Expression Regulation; Genetic Variation; Humans; RNA, Messenger / genetics; Transcription, Genetic; Transcriptome / genetics
Source: ORCID
Added: September 28, 2022

2012 journal article

Epigenetic control of alternative mRNA processing at the imprinted Herc3/Nap1l5 locus.

40(18), 8917–8926.

By: S. Böhm*, M. Cowley*, R. Oakey*, R. Schulz* & A. Wood*

MeSH headings : Alleles; Animals; DNA Methylation; Genetic Loci; Genomic Imprinting; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Nuclear Proteins; Polyadenylation; Protein Isoforms / genetics; Protein Isoforms / metabolism; RNA, Messenger / metabolism; Transcription, Genetic; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism
Source: ORCID
Added: September 28, 2022

2012 journal article

Protection against De Novo Methylation Is Instrumental in Maintaining Parent-of-Origin Methylation Inherited from the Gametes

Molecular Cell, 47(6), 909–920.

By: C. Proudhon, R. Duffié, S. Ajjan, M. Cowley*, J. Iranzo, G. Carbajosa, H. Saadeh, M. Holland ...

MeSH headings : Animals; Blastocyst / metabolism; Cadherins / genetics; DNA Methylation; Embryo, Mammalian / cytology; Embryo, Mammalian / metabolism; Fertilization; Genetic Testing; Genomic Imprinting; Germ Cells / metabolism; Mice; Oocytes / metabolism; Pseudogenes; Sequence Analysis, DNA
Sources: Crossref, ORCID
Added: August 28, 2020

2012 journal article

Resetting for the Next Generation

Molecular Cell, 48(6), 819–821.

By: M. Cowley* & R. Oakey*

Sources: Crossref, ORCID
Added: August 28, 2020

2011 journal article

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

Nature, 469(7331), 534–538.

By: A. Garfield*, M. Cowley*, F. Smith*, K. Moorwood*, J. Stewart-Cox*, K. Gilroy*, S. Baker*, J. Xia* ...

MeSH headings : Alleles; Animals; Behavior, Animal / physiology; Central Nervous System / embryology; Female; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; Gene Expression Regulation, Developmental; Genomic Imprinting / genetics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Social Dominance
Sources: Crossref, ORCID
Added: August 28, 2020

2011 journal article

Human imprinted retrogenes exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes.

Nucleic Acids Research, 39(11), 4577–4586.

MeSH headings : Alleles; Animals; Chromatin / metabolism; DNA Methylation; Genomic Imprinting; Histones / metabolism; Humans; Mice; Promoter Regions, Genetic; Retroelements
Source: ORCID
Added: September 28, 2022

2011 journal article

Short interspersed element (SINE) depletion and long interspersed element (LINE) abundance are not features universally required for imprinting.

PloS One, 6(4), 18953.

By: M. Chahal*, M. Cowley*, R. McCole*, R. Oakey*, G. Saadat*, R. Schulz*, B. de*

MeSH headings : Alleles; Animals; DNA Methylation; Genomic Imprinting; Humans; Long Interspersed Nucleotide Elements / genetics; Mice; Mice, Inbred C57BL; Short Interspersed Nucleotide Elements / genetics
Source: ORCID
Added: September 28, 2022

2010 journal article

Maternally-inherited Grb10 reduces placental size and efficiency

Developmental Biology, 337(1), 1–8.

By: M. Charalambous*, M. Cowley*, F. Geoghegan*, F. Smith*, E. Radford*, B. Marlow*, C. Graham*, L. Hurst*, A. Ward*

author keywords: Adapter protein; Cell signalling; Epigenetics; Genomic imprinting; Growth factor receptor-bound protein; Growth regulation; IGF; Insulin-like growth factor; Mouse; Placenta
MeSH headings : Alleles; Animals; Endothelium / metabolism; Female; GRB10 Adaptor Protein / analysis; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / physiology; Genomic Imprinting; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Placenta / pathology; Placenta / physiology; Pregnancy
Sources: Crossref, ORCID
Added: August 28, 2020

2010 journal article

Retrotransposition and genomic imprinting.

9(4), 340–346.

By: M. Cowley* & R. Oakey

author keywords: retrotransposition; retrogenes; genomic imprinting; epigenetics
MeSH headings : Animals; DNA Methylation / genetics; Epigenesis, Genetic / genetics; Genomic Imprinting / genetics; Humans; Models, Genetic; Retroelements / genetics
Source: ORCID
Added: September 28, 2022

Employment

Updated: April 27th, 2021 20:36

2020 - present

North Carolina State University Raleigh, North Carolina, US
Associate Professor Biological Sciences

2014 - 2020

North Carolina State University Raleigh, NC, US
Assistant Professor Biological Sciences

2012 - 2014

King's College London London, London, GB
London Law Trust Medal Fellow Medical & Molecular Genetics

2009 - 2012

King's College London London, London, GB
Postdoctoral Research Scholar Medical & Molecular Genetics

Education

Updated: March 24th, 2017 15:40

2005 - 2009

University of Bath Bath, Bath and North East Somer, GB
Ph.D., Developmental Genetics Biology & Biochemistry

2002 - 2005

University of Warwick Coventry, Coventry, GB
B.Sc. (Hons), Biological Sciences with Molecular Genetics Biological Sciences

Funding History

Funding history based on the linked ORCID record. Updated: April 27th, 2021 20:37

grant May 19, 2020 - March 31, 2025
The Imprinted Gene Network in the programming of Non-Alcoholic Fatty Liver Disease by early life cadmium exposure
National Institute of Environmental Health Sciences
grant September 15, 2017 - August 31, 2020
Epigenetic mechanisms linking in utero cadmium exposure to hepatic steatosis
National Institute of Environmental Health Sciences