Michael Anthony Cowley

Works (32)

Updated: March 2nd, 2026 15:51

2025 article

Cadmium exposure during adolescence and young adulthood induces signatures of metabolic dysfunction-associated steatotic liver disease

Dameris, L., Hartsell, J., Chappel, J., Liu, X., & Cowley, M. (2025, November 4). Scientific Reports.

By: L. Dameris  n, J. Hartsell n, J. Chappel  n, X. Liu  n & M. Cowley n 

MeSH headings : Animals; Cadmium / toxicity; Mice; Mice, Inbred C57BL; Liver / metabolism; Liver / drug effects; Liver / pathology; Fatty Liver / metabolism; Fatty Liver / chemically induced; Fatty Liver / pathology; Male; Lipid Metabolism / drug effects; Female; Disease Models, Animal
topics (OpenAlex): Heavy Metal Exposure and Toxicity; Carcinogens and Genotoxicity Assessment; Heavy metals in environment
Source: ORCID
Added: November 4, 2025

2025 article

Dietary Iron Supplementation Protects Against Growth Restriction and Metabolic Dysfunction‐Associated Steatotic Liver Disease in Perinatal Cadmium‐Exposed Mice

Lichtler, R., Klossner, H., Smith, N., Hoyo, C., & Cowley, M. (2025, June 17). FASEB BioAdvances, Vol. 6.

By: R. Lichtler n, H. Klossner n, N. Smith n, C. Hoyo n  & M. Cowley n 

author keywords: anemia; cadmium; dietary supplements; iron deficiency; liver diseases; maternal exposure; pregnancy
topics (OpenAlex): Heavy Metal Exposure and Toxicity; Trace Elements in Health; Birth, Development, and Health
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2. Zero Hunger (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 17, 2025

2025 article

Environmental Contaminants, Iron Deficiency, and Iron‐Deficiency Anemia: A Review of the Literature

Lichtler, R., & Cowley, M. (2025, January 1). (A. Ulaganathan, Ed.). Scientifica.

By: R. Lichtler  n & M. Cowley n 

Ed(s): A. Ulaganathan

topics (OpenAlex): Heavy Metal Exposure and Toxicity; Air Quality and Health Impacts; Healthcare and Environmental Waste Management
Source: ORCID
Added: September 9, 2025

2025 article

The effects of developmental cadmium exposure on health and disease

Hudson, K. M., Dameris, L., Lichtler, R., & Cowley, M. (2025, June 1). Disease Models & Mechanisms, Vol. 18.

By: K. Hudson n, L. Dameris n, R. Lichtler n & M. Cowley n 

author keywords: Cadmium; Developmental exposure; Exposure models; Fetal growth restriction; Disease programming; Organ systems
MeSH headings : Cadmium / toxicity; Humans; Animals; Pregnancy; Female; Environmental Exposure / adverse effects; Placenta / drug effects; Disease; Health; Prenatal Exposure Delayed Effects
topics (OpenAlex): Heavy Metal Exposure and Toxicity; Trace Elements in Health; Aluminum toxicity and tolerance in plants and animals
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 9, 2025

2024 article

Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7 family of signalling adaptor proteins have overlapping functions in the regulation of fetal growth and post-natal glucose metabolism

Moorwood, K., Smith, F. M., Garfield, A. S., Cowley, M., Holt, L. J., Daly, R. J., & Ward, A. (2024, September 30). BMC Biology, Vol. 22.

By: K. Moorwood *, F. Smith*, A. Garfield *, M. Cowley n , L. Holt *, R. Daly *, A. Ward

author keywords: Cell signalling; Developmental biology; Epistasis; Fetal growth; Genomic imprinting; Insulin; Growth factor receptor; Mouse genetics; mTORC1
MeSH headings : Animals; Female; Male; Mice; Adaptor Proteins, Signal Transducing / metabolism; Adaptor Proteins, Signal Transducing / genetics; Fetal Development / genetics; Glucose / metabolism; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; GRB7 Adaptor Protein / metabolism; GRB7 Adaptor Protein / genetics; Mice, Knockout; Signal Transduction
topics (OpenAlex): Birth, Development, and Health; Pancreatic function and diabetes; FOXO transcription factor regulation
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Sources: Web Of Science, NC State University Libraries
Added: October 8, 2024

2023 article

LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response

Simmers, M. D., Jima, D. D., Tsuji, Y., & Cowley, M. (2023, June 1). Frontiers in Cell and Developmental Biology, Vol. 11.

By: M. Simmers n, D. Jima n, Y. Tsuji n  & M. Cowley n 

author keywords: lncRNA; Tuna; placental insufficiency; fetal growth restriction (FGR); Cadmium; Nrf2; oxidative stress
topics (OpenAlex): Cancer-related molecular mechanisms research; MicroRNA in disease regulation; Circular RNAs in diseases; Heavy Metal Exposure and Toxicity
TL;DR: The lncRNA Tuna is identified as a potential novel player in Cd-induced placental insufficiency and increases NRF2/NRF2 both at the transcript and protein levels, confirming that Tuna activates oxidative stress response genes through this pathway. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 3, 2023

2022 article

Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction

Simmers, M. D., Hudson, K. M., Baptissart, M., & Cowley, M. (2022, June 30). Epigenetics, Vol. 7.

By: M. Simmers n, K. Hudson  n, M. Baptissart n & M. Cowley n 

author keywords: Genomic imprinting; imprinted genes; DNA methylation; placenta; cadmium; foetal growth restriction; CDKN1C; toxic metal
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Prenatal Screening and Diagnostics; Renal and related cancers
TL;DR: It is concluded that the Cd-associated increase in Cdkn1c expression can be fully explained by alterations to placental structure, and it is shown that CdKn1c is expressed primarily in the placental labyrinth which is proportionally increased in size in response to Cd. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 11, 2022

2022 article

Genomic map of candidate human imprint control regions: the imprintome

Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, July 4). Epigenetics, Vol. 6.

By: D. Jima n, D. Skaar n , A. Planchart n , A. Motsinger-Reif n, S. Cevik  n, S. Park n, M. Cowley n , F. Wright n ...

author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Genetics and Neurodevelopmental Disorders
TL;DR: This draft of the human imprintome will allow for the systematic determination of the role of early-acquired imprinting dysregulation in the pathogenesis of human diseases and developmental and behavioural disorders. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 11, 2022

2022 article

The imprinted geneZac1regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease

Riegl, S. D., Starnes, C., Jima, D. D., Baptissart, M., Diehl, A. M., Belcher, S. M., & Cowley, M. (2022, October 6). Toxicological Sciences, Vol. 10.

By: S. Riegl n, C. Starnes n, D. Jima n, M. Baptissart n, A. Diehl *, S. Belcher n , M. Cowley n 

author keywords: nonalcoholic fatty liver disease; developmental toxicology; epigenetics; cadmium; genomic imprinting; developmental programming
MeSH headings : Mice; Animals; Non-alcoholic Fatty Liver Disease / genetics; Non-alcoholic Fatty Liver Disease / metabolism; Cadmium; Cadmium Chloride / toxicity; PPAR gamma; Liver / metabolism; Fibrosis
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Renal and related cancers
TL;DR: It is demonstrated that developmental Cd exposure is sufficient to program NAFLD in later life, and Zac1 and the IGN are established as key regulators of prosteatotic and profibrotic pathways, two of the major pathological hallmarks ofNAFLD. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 29, 2022

2022 article

Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome

Baptissart, M., Bradish, C. M., Jones, B. S., Walsh, E., Tehrani, J., Marrero‐Colon, V., … Cowley, M. (2022, January 27). Hepatology, Vol. 2.

By: M. Baptissart n, C. Bradish n , B. Jones n, E. Walsh n, J. Tehrani  n, V. Marrero‐Colon n , S. Mehta  n, D. Jima n ...

MeSH headings : Animals; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Disease Models, Animal; Gene Regulatory Networks / genetics; Gene Regulatory Networks / physiology; Genes, Tumor Suppressor / physiology; Metabolic Syndrome / complications; Metabolic Syndrome / genetics; Metabolic Syndrome / metabolism; Mice; Non-alcoholic Fatty Liver Disease / complications; Non-alcoholic Fatty Liver Disease / genetics; Non-alcoholic Fatty Liver Disease / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism; Transforming Growth Factor beta1
topics (OpenAlex): Liver Disease Diagnosis and Treatment; Pancreatic function and diabetes; Birth, Development, and Health
TL;DR: It is hypothesized that imprinted genes, defined by expression from a single parental allele, play a key role in maternal MetS‐induced NAFLD, due to their susceptibility to environmental stressors and their functions in liver homeostasis. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 28, 2022

2021 article

Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart

Prickett, A. R., Montibus, B., Barkas, N., Amante, S. M., Franco, M. M., Cowley, M., … Oakey, R. J. (2021, June 22). Frontiers in Cell and Developmental Biology, Vol. 6.

By: A. Prickett*, B. Montibus *, N. Barkas *, S. Amante *, M. Franco *, M. Cowley* , W. Puszyk*, M. Shannon* ...

author keywords: dopa decarboxylase; knock-out; imprinting; heart; mouse; human
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Congenital heart defects research; Genetics and Neurodevelopmental Disorders
TL;DR: Comparative studies in the human developing heart reveal a paternal expression bias with polymorphic imprinting patterns between individual human hearts at DDC_EXON1a, a finding consistent with other imprinted genes in human. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 12, 2021

2021 article

Transcriptomic, proteomic, and metabolomic analyses identify candidate pathways linking maternal cadmium exposure to altered neurodevelopment and behavior

Hudson, K. M., Shiver, E., Yu, J., Mehta, S., Jima, D. D., Kane, M. A., … Cowley, M. (2021, August 11). Scientific Reports, Vol. 8.

By: K. Hudson n, E. Shiver n, J. Yu *, S. Mehta  n, D. Jima n, M. Kane *, H. Patisaul n , M. Cowley n 

MeSH headings : Animals; Body Weight / drug effects; Body Weight / genetics; Cadmium / toxicity; Female; Fetal Development / drug effects; Fetal Development / genetics; Humans; Maternal Exposure; Metabolomics / methods; Mice; Mice, Inbred C57BL; Neurodevelopmental Disorders / chemically induced; Neurodevelopmental Disorders / genetics; Placenta / drug effects; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Proteomics / methods; Transcriptome / genetics
topics (OpenAlex): Heavy Metal Exposure and Toxicity; Birth, Development, and Health; Health, Environment, Cognitive Aging
TL;DR: The identification of multiple pathways perturbed in the developing brain provides a basis for future studies determining the mechanistic links between maternal Cd exposure and altered neurodevelopment and behavior. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 30, 2021

2020 article

Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing

Amante, S. M., Montibus, B., Cowley, M., Barkas, N., Setiadi, J., Saadeh, H., … Oakey, R. J. (2020, July 1). Nucleic Acids Research, Vol. 9, pp. 8349–8359.

By: S. Amante *, B. Montibus *, M. Cowley* , N. Barkas *, J. Setiadi*, H. Saadeh *, J. Giemza*, S. Contreras-Castillo * ...

MeSH headings : Animals; Cell Differentiation / genetics; Chromatin / genetics; CpG Islands / genetics; DNA Methylation / genetics; Epigenesis, Genetic; Genome / genetics; Histone Code / genetics; Humans; Promoter Regions, Genetic; Protein Processing, Post-Translational / genetics; Pseudogenes / genetics; RNA Precursors / genetics; RNA Precursors / metabolism; Transcription, Genetic
topics (OpenAlex): RNA Research and Splicing; RNA modifications and cancer; Cancer-related gene regulation
TL;DR: It is suggested that iCGI transcription, rather than H3K36me3 or DNA methylation, interfere with host gene transcription and pre-mRNA processing genomewide and contributes to the spatiotemporal diversification of both the transcriptome and proteome. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 19, 2020

2019 article

Maternal cadmium exposure in the mouse leads to increased heart weight at birth and programs susceptibility to hypertension in adulthood

Hudson, K. M., Belcher, S. M., & Cowley, M. (2019, September 19). Scientific Reports, Vol. 9.

By: K. Hudson n, S. Belcher n  & M. Cowley n 

Contributors: K. Hudson n, S. Belcher n  & M. Cowley n 

MeSH headings : Animals; Animals, Newborn; Body Weight / drug effects; Cadmium / adverse effects; Disease Models, Animal; Female; Gene Expression Profiling / methods; Gene Expression Regulation / drug effects; Gene Regulatory Networks / drug effects; Heart / anatomy & histology; Heart / drug effects; Hypotension / chemically induced; Hypotension / genetics; Maternal Exposure / adverse effects; Metabolic Networks and Pathways / drug effects; Mice; Organ Size / drug effects; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Sequence Analysis, RNA
topics (OpenAlex): Heavy Metal Exposure and Toxicity; Effects and risks of endocrine disrupting chemicals; Birth, Development, and Health; Mercury impact and mitigation studies
TL;DR: It is proposed that a maternal Cd exposure-induced iron deficiency leads to altered cellular metabolic pathways and hypoxic conditions during fetal development; this stress may contribute to increased heart weight at birth and the programming of susceptibility to hypertension in adulthood. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 7, 2019

2019 article

Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study

Martin, C. L., Jima, D., Sharp, G. C., McCullough, L. E., Park, S. S., Gowdy, K. M., … Hoyo, C. (2019, March 26). Epigenetics, Vol. 14, pp. 325–340.

By: C. Martin *, D. Jima n, G. Sharp *, L. McCullough *, S. Park n, K. Gowdy *, D. Skaar n , M. Cowley n  ...

author keywords: DNA methylation; epigenome-wide association study; maternal obesity; offspring body mass index; offspring blood pressure; cardiometabolic health; ALSPAC; NEST
MeSH headings : Adult; Blood Pressure; Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / genetics; Child; Child, Preschool; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Genome-Wide Association Study; Humans; Infant, Newborn / blood; Infant, Newborn / growth & development; Male; Membrane Transport Proteins / genetics; Metabolic Syndrome / epidemiology; Metabolic Syndrome / genetics; Obesity / epidemiology; Obesity / genetics
topics (OpenAlex): Birth, Development, and Health; Epigenetics and DNA Methylation; Gestational Diabetes Research and Management
TL;DR: Findings suggest sex-specific effects at CpG sites of the TAPBP gene were associated with BMI z-score and systolic BP percentile in female and syStolic and diastolicBP percentile in male offspring, which, if causal, may explain observed sex- specific effects of maternal obesity. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 29, 2019

2018 article

Effects of Cadmium Exposure on DNA Methylation at Imprinting Control Regions and Genome-Wide in Mothers and Newborn Children

Cowley, M., Skaar, D. A., Jima, D. D., Maguire, R. L., Hudson, K. M., Park, S. S., … Hoyo, C. (2018, March 12). Environmental Health Perspectives, Vol. 3.

By: M. Cowley n , D. Skaar  n, D. Jima  n, R. Maguire  n, K. Hudson  n, S. Park  n, P. Sorrow  n, C. Hoyo  n

MeSH headings : Cadmium / toxicity; DNA Methylation / drug effects; DNA Methylation / genetics; Epigenesis, Genetic / drug effects; Epigenesis, Genetic / ethics; Female; Genomic Imprinting / drug effects; Genomic Imprinting / genetics; Humans; Infant, Newborn; Male; Mothers
topics (OpenAlex): Epigenetics and DNA Methylation; Genetic Syndromes and Imprinting; Prenatal Screening and Diagnostics
TL;DR: The findings suggest that ICRs may be hot spots for perturbation by Cadmium, motivating further study of these loci to investigate potential mechanisms of cadmium action and suggest that epigenetic changes may contribute to the etiology of cad mium-associated diseases. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, NC State University Libraries
Added: September 28, 2022

2018 journal article

Effects of cadmium exposure on DNA methylation at imprinting control regions and genome-wide in mothers and newborn children

Environmental Health Perspectives, 126(3).

By: M. Cowley , D. Skaar , D. Jima, R. Maguire, K. Hudson, S. Park, P. Sorrow, C. Hoyo 

Source: NC State University Libraries
Added: August 6, 2018

2018 article

Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam

Baptissart, M., Lamb, H. E., To, K., Bradish, C., Tehrani, J., Reif, D., & Cowley, M. (2018, November 14). Proceedings of the Royal Society B Biological Sciences, Vol. 285, p. 20181237.

By: M. Baptissart n, H. Lamb n, K. To n, C. Bradish n , J. Tehrani  n, D. Reif n , M. Cowley n 

Contributors: M. Baptissart n, H. Lamb n, K. To n, C. Bradish n , J. Tehrani  n, D. Reif n , M. Cowley n 

MeSH headings : Animals; Animals, Newborn / physiology; Diet, High-Fat; Female; Maternal Behavior / physiology; Maternal Exposure; Mice / physiology; Mice, Inbred C57BL; Pregnancy
topics (OpenAlex): Neuroendocrine regulation and behavior; Birth, Development, and Health; Stress Responses and Cortisol
TL;DR: In utero exposure to HF diet programmes physiological changes in the offspring which influence the maternal behaviours of their dam after birth are suggested. (via Semantic Scholar)
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Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: December 10, 2018

2016 review

Regulatory links between imprinted genes: Evolutionary predictions and consequences

By: M. Patten, M. Cowley , R. Oakey & R. Feil

Source: NC State University Libraries
Added: August 6, 2018

2016 article

Regulatory links between imprinted genes: evolutionary predictions and consequences

Patten, M. M., Cowley, M., Oakey, R. J., & Feil, R. (2016, February 3). Proceedings of the Royal Society B Biological Sciences, Vol. 283.

By: M. Patten *, M. Cowley n , R. Oakey * & R. Feil *

author keywords: evolution; genomic imprinting; gene network; trans regulation
MeSH headings : Animals; Biological Evolution; Gene Regulatory Networks; Genomic Imprinting; Mammals / genetics
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Prenatal Screening and Diagnostics
TL;DR: An evolutionary view of these trans-regulatory effects provides a novel interpretation of the logic of gene networks within species and has implications for the origin of reproductive isolation between species. (via Semantic Scholar)
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Source: ORCID
Added: September 28, 2022

2015 article

Coadaptation between Mother and Offspring: Why Not?

Wolf, J. B., Cowley, M., & Ward, A. (2015, March 18). PLoS Biology, Vol. 13, p. 1002085,

By: J. Wolf *, M. Cowley n  & A. Ward *

MeSH headings : Animals; Body Size / genetics; Female; GRB10 Adaptor Protein / genetics
topics (OpenAlex): Genetic Syndromes and Imprinting; Assisted Reproductive Technology and Twin Pregnancy; Prenatal Screening and Diagnostics
TL;DR: A Formal Comment has challenged the interpretation of a study into an imprinted gene, maintaining that conflict, rather than mother-offspring co-adaptation, provides a better mechanistic explanation. (via Semantic Scholar)
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Sources: ORCID, Web Of Science
Added: August 6, 2018

2014 article

Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1genes

Madon-Simon, M., Cowley, M., Garfield, A. S., Moorwood, K., Bauer, S. R., & Ward, A. (2014, December 1). BMC Biology, Vol. 12, p. 771,

By: M. Madon-Simon*, M. Cowley n , A. Garfield *, K. Moorwood *, S. Bauer * & A. Ward *

author keywords: Adiposity; Body proportions; Genomic imprinting; Glucose-regulated metabolism; Growth; Mouse genetics
MeSH headings : Absorptiometry, Photon; Adipose Tissue / metabolism; Animals; Calcium-Binding Proteins; Cell Proliferation; Female; Fetal Development / genetics; Fibroblasts / metabolism; G2 Phase; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; Genomic Imprinting; Glucose Tolerance Test; History, Ancient; Insulin-Like Growth Factor II / genetics; Insulin-Like Growth Factor II / metabolism; Intercellular Signaling Peptides and Proteins / genetics; Intercellular Signaling Peptides and Proteins / metabolism; Liver / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; S Phase; Triglycerides / blood
topics (OpenAlex): Genetic Syndromes and Imprinting; Pancreatic function and diabetes; Epigenetics and DNA Methylation
TL;DR: Genetic and physiological evidence is presented that Dlk1 and Grb10 define a mammalian growth axis that is separate from the IGF pathway, yet also features an antagonistic imprinted gene pair. (via Semantic Scholar)
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Source: ORCID
Added: September 28, 2022

2014 article

Developmental Programming Mediated by Complementary Roles of Imprinted Grb10 in Mother and Pup

Cowley, M., Garfield, A. S., Madon-Simon, M., Charalambous, M., Clarkson, R. W., Smalley, M. J., … Ward, A. (2014, February 25). PLoS Biology, Vol. 12, p. 1001799,

By: M. Cowley* , A. Garfield *, M. Madon-Simon*, M. Charalambous *, R. Clarkson *, M. Smalley *, H. Kendrick *, A. Isles * ...

MeSH headings : Animals; Body Size / genetics; Female; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; Gene Expression Regulation, Developmental; Genomic Imprinting; Karyopherins / physiology; Lactation / genetics; Mice; Mice, Knockout; Receptors, Cytoplasmic and Nuclear / physiology; STAT5 Transcription Factor / physiology
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Birth, Development, and Health
TL;DR: A mouse genetic study reveals that a single gene acting in both mother and offspring has a central role in the uniquely mammalian phenomenon of nutrient provisioning through the placenta and the mammary gland. (via Semantic Scholar)
Source: ORCID
Added: September 28, 2022

2013 article

Transposable Elements Re-Wire and Fine-Tune the Transcriptome

Cowley, M., & Oakey, R. J. (2013, January 24). PLoS Genetics, Vol. 9, p. 1003234.

By: M. Cowley*  & R. Oakey *

MeSH headings : DNA Transposable Elements / genetics; Evolution, Molecular; Gene Expression Regulation; Genetic Variation; Humans; RNA, Messenger / genetics; Transcription, Genetic; Transcriptome / genetics
topics (OpenAlex): Chromosomal and Genetic Variations; RNA modifications and cancer; RNA Research and Splicing
TL;DR: How TEs—particularly retrotransposons—contribute to transcript diversity and consider their potential significance as a source of small RNAs that regulate host gene transcription are explored. (via Semantic Scholar)
Source: ORCID
Added: September 28, 2022

2012 article

Epigenetic control of alternative mRNA processing at the imprinted Herc3/Nap1l5 locus

Cowley, M., Wood, A. J., Böhm, S., Schulz, R., & Oakey, R. J. (2012, July 11). Nucleic Acids Research, Vol. 40, pp. 8917–8926.

By: M. Cowley* , A. Wood *, S. Böhm *, R. Schulz * & R. Oakey *

MeSH headings : Alleles; Animals; DNA Methylation; Genetic Loci; Genomic Imprinting; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Nuclear Proteins; Polyadenylation; Protein Isoforms / genetics; Protein Isoforms / metabolism; RNA, Messenger / metabolism; Transcription, Genetic; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; RNA modifications and cancer
TL;DR: Changes in DNA methylation on the maternal allele at the Nap1l5 promoter increases the use of an internal Herc3 polyadenylation site and alters exon splicing, which demonstrate the influence of epigenetic mechanisms in regulating HerC3 alternative mRNA processing. (via Semantic Scholar)
Source: ORCID
Added: September 28, 2022

2012 journal article

Protection against De Novo Methylation Is Instrumental in Maintaining Parent-of-Origin Methylation Inherited from the Gametes

Molecular Cell, 47(6), 909–920.

By: C. Proudhon *, R. Duffié *, S. Ajjan*, M. Cowley* , J. Iranzo *, G. Carbajosa *, H. Saadeh *, M. Holland * ...

MeSH headings : Animals; Blastocyst / metabolism; Cadherins / genetics; DNA Methylation; Embryo, Mammalian / cytology; Embryo, Mammalian / metabolism; Fertilization; Genetic Testing; Genomic Imprinting; Germ Cells / metabolism; Mice; Oocytes / metabolism; Pseudogenes; Sequence Analysis, DNA
topics (OpenAlex): Epigenetics and DNA Methylation; Genetic Syndromes and Imprinting; Prenatal Screening and Diagnostics
TL;DR: Evidence is provided that protection against de novo methylation acts as an equal major pivot, at implantation and throughout life. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020

2012 journal article

Resetting for the Next Generation

Molecular Cell, 48(6), 819–821.

By: M. Cowley*  & R. Oakey *

topics (OpenAlex): Epigenetics and DNA Methylation; ICT in Developing Communities; Children's Rights and Participation
TL;DR: In this issue of Molecular Cell, Seisenberger et al. (2012) refine DNA methylation mapping to interrogate the epigenetic reprogramming of primordial germ cells, defining the timings of methylation loss, linking to pluripotency, and identifying potential routes to transgenerational epigenetic inheritance. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020

2011 journal article

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

Nature, 469(7331), 534–538.

By: A. Garfield *, M. Cowley* , F. Smith*, K. Moorwood *, J. Stewart-Cox*, K. Gilroy*, S. Baker *, J. Xia * ...

MeSH headings : Alleles; Animals; Behavior, Animal / physiology; Central Nervous System / embryology; Female; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; Gene Expression Regulation, Developmental; Genomic Imprinting / genetics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Social Dominance
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Prenatal Screening and Diagnostics
TL;DR: It is demonstrated that within the brain Grb10 is expressed from the paternal allele from fetal life into adulthood and that ablation of this expression engenders increased social dominance specifically among other aspects of social behaviour, a finding supported by the observed increase in allogrooming by paternal Grb 10-deficient animals. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020

2011 article

Human imprinted retrogenes exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes

Monk, D., Arnaud, P., Frost, J. M., Wood, A. J., Cowley, M., Martin-Trujillo, A., … Oakey, R. J. (2011, February 7). Nucleic Acids Research, Vol. 39, pp. 4577–4586.

By: D. Monk*, P. Arnaud *, J. Frost *, A. Wood *, M. Cowley* , A. Martin-Trujillo *, A. Guillaumet-Adkins *, I. Platas * ...

MeSH headings : Alleles; Animals; Chromatin / metabolism; DNA Methylation; Genomic Imprinting; Histones / metabolism; Humans; Mice; Promoter Regions, Genetic; Retroelements
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Prenatal Screening and Diagnostics
TL;DR: Two human retrogenes showed monoallelic enrichment of active, but not of repressive marks suggesting a partial uncoupling of the relationship between DNA methylation and repressive histone methylation, possibly due to the smaller size and lower CpG density of these DMRs. (via Semantic Scholar)
Source: ORCID
Added: September 28, 2022

2011 article

Short Interspersed Element (SINE) Depletion and Long Interspersed Element (LINE) Abundance Are Not Features Universally Required for Imprinting

Cowley, M., Burca, A., McCole, R. B., Chahal, M., Saadat, G., Oakey, R. J., & Schulz, R. (2011, April 20). PLoS ONE, Vol. 6, p. 18953.

By: M. Cowley* , A. Burca*, R. McCole *, M. Chahal*, G. Saadat*, R. Oakey *, R. Schulz *

MeSH headings : Alleles; Animals; DNA Methylation; Genomic Imprinting; Humans; Long Interspersed Nucleotide Elements / genetics; Mice; Mice, Inbred C57BL; Short Interspersed Nucleotide Elements / genetics
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Genomic variations and chromosomal abnormalities
TL;DR: The repeat element content of imprinted retrogene loci with non-imprinted controls that have a similar locus organisation is compared, suggesting that the paucity of SINEs and relative abundance of LINEs at imprinted loci reported by others is not a sequence feature universally required for imprinting. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: ORCID
Added: September 28, 2022

2010 article

Retrotransposition and genomic imprinting

Cowley, M., & Oakey, R. J. (2010, June 29). Briefings in Functional Genomics, Vol. 9, pp. 340–346.

By: M. Cowley*  & R. Oakey

author keywords: retrotransposition; retrogenes; genomic imprinting; epigenetics
MeSH headings : Animals; DNA Methylation / genetics; Epigenesis, Genetic / genetics; Genomic Imprinting / genetics; Humans; Models, Genetic; Retroelements / genetics
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Chromosomal and Genetic Variations
TL;DR: A distinct class of imprinted genes, which have arisen by retrotransposition, and which have the potential to be used as models for the dissection of the fundamental features and mechanisms required for imprinting are reviewed. (via Semantic Scholar)
Source: ORCID
Added: September 28, 2022

2009 journal article

Maternally-inherited Grb10 reduces placental size and efficiency

Developmental Biology, 337(1), 1–8.

By: M. Charalambous *, M. Cowley* , F. Geoghegan*, F. Smith*, E. Radford *, B. Marlow *, C. Graham*, L. Hurst *, A. Ward *

author keywords: Adapter protein; Cell signalling; Epigenetics; Genomic imprinting; Growth factor receptor-bound protein; Growth regulation; IGF; Insulin-like growth factor; Mouse; Placenta
MeSH headings : Alleles; Animals; Endothelium / metabolism; Female; GRB10 Adaptor Protein / analysis; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / physiology; Genomic Imprinting; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Placenta / pathology; Placenta / physiology; Pregnancy
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Birth, Development, and Health
TL;DR: It is shown that following disruption of the maternal allele in mice, the labyrinthine volume was increased in a manner consistent with a cell-autonomous function of Grb10 and the enlarged placenta was more efficient in supporting foetal growth, becoming the first example of a gene that acts to limit placental size and efficiency. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020

Employment

Updated: April 27th, 2021 20:36

2020 - present

North Carolina State University Raleigh, North Carolina, US
Associate Professor Biological Sciences

2014 - 2020

North Carolina State University Raleigh, NC, US
Assistant Professor Biological Sciences

2012 - 2014

King's College London London, London, GB
London Law Trust Medal Fellow Medical & Molecular Genetics

2009 - 2012

King's College London London, London, GB
Postdoctoral Research Scholar Medical & Molecular Genetics

Education

Updated: March 24th, 2017 15:40

2005 - 2009

University of Bath Bath, Bath and North East Somer, GB
Ph.D., Developmental Genetics Biology & Biochemistry

2002 - 2005

University of Warwick Coventry, Coventry, GB
B.Sc. (Hons), Biological Sciences with Molecular Genetics Biological Sciences

Funding History

Funding history based on the linked ORCID record. Updated: April 27th, 2021 20:37

grant May 19, 2020 - March 31, 2025
The Imprinted Gene Network in the programming of Non-Alcoholic Fatty Liver Disease by early life cadmium exposure
National Institute of Environmental Health Sciences
grant September 15, 2017 - August 31, 2020
Epigenetic mechanisms linking in utero cadmium exposure to hepatic steatosis
National Institute of Environmental Health Sciences

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