James W. Mahaffey
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Works (15)
Updated: April 3rd, 2024 20:04
2013 journal article
New Components of Drosophila Leg Development Identified through Genome Wide Association Studies
PLOS ONE, 8(4).
MeSH headings : Animals; Cell Communication; Drosophila Proteins / antagonists & inhibitors; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / embryology; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Embryo, Nonmammalian; Extremities / embryology; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Genome-Wide Association Study; Imaginal Discs / embryology; Imaginal Discs / metabolism; Larva / genetics; Larva / growth & development; Larva / metabolism; Morphogenesis / genetics; Mutation; RNA, Small Interfering / genetics; Signal Transduction
TL;DR:
The utility of the Genome Wide Association Study utilizing the natural genetic variation in leg proportionality found in the Drosophila Genetic Reference Panel fly lines is demonstrated, integrating the tools of quantitative and molecular genetics to study developmental processes, and new insights are provided into the pathways and networks involved in Drosophile leg development.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 review
The evolving role of the orphan nuclear receptor ftz-f1, a pair-rule segmentation gene
[Review of ]. EVOLUTION & DEVELOPMENT, 15(6), 406–417.
MeSH headings : Animals; Drosophila melanogaster / metabolism; Evolution, Molecular; Gene Expression Regulation, Developmental; Insect Proteins / chemistry; Insect Proteins / genetics; Insect Proteins / metabolism; Orphan Nuclear Receptors / chemistry; Orphan Nuclear Receptors / genetics; Orphan Nuclear Receptors / metabolism; Tribolium / embryology; Tribolium / genetics; Tribolium / metabolism
TL;DR:
It is proposed that the dependence of Dm‐Ftz‐F1 on interaction with the homeodomain protein Ftz which is expressed in stripes in Drosophila, loosened constraints on DM‐ftz‐f1 expression, allowing for ubiquitous expression of this pair‐rule gene in Dosophila.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Inference on treatment effects from a randomized clinical trial in the presence of premature treatment discontinuation: the SYNERGY trial
BIOSTATISTICS, 12(2), 258–269.
author keywords: Dynamic treatment regime; Inverse probability weighting; Potential outcomes; Proportional hazards model
MeSH headings : Acute Coronary Syndrome / drug therapy; Algorithms; Computer Simulation; Endpoint Determination; Enoxaparin / administration & dosage; Enoxaparin / adverse effects; Enoxaparin / therapeutic use; Hemorrhage / etiology; Heparin / administration & dosage; Heparin / adverse effects; Heparin / therapeutic use; Humans; Intention to Treat Analysis; Models, Statistical; Monte Carlo Method; Mortality; Multicenter Studies as Topic; Probability; Proportional Hazards Models; Randomized Controlled Trials as Topic / methods; Survival Analysis; Treatment Outcome; Withholding Treatment / statistics & numerical data
TL;DR:
The Superior Yield of the New Strategy of Enoxaparin, Revascularization, and GlYcoprotein IIb/IIIa inhibitors (SYNERGY) was a randomized, open-label, multicenter clinical trial comparing 2 anticoagulant drugs on the basis of time-to-event endpoints.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Genomic Consequences of Background Effects on scalloped Mutant Expressivity in the Wing of Drosophila melanogaster
GENETICS, 181(3), 1065–1076.
MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / cytology; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Epistasis, Genetic; Gene Expression Regulation; Genetic Linkage; Genetic Variation; Genome, Insect / genetics; Genomics; Molecular Sequence Data; Mutation; Nuclear Proteins / genetics; Oligonucleotide Array Sequence Analysis; Transcription Factors / genetics; Transcription, Genetic; Wings, Animal / metabolism
TL;DR:
This study demonstrates that phenotypic expressivity of the scallopedE3 (sdE3) mutation of Drosophila melanogaster is background dependent and is the result of at least one major modifier segregating between two standard lab wild-type strains and demonstrates that the epistatic interaction between sdE3 and an optomotor blind mutation is backgrounddependent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
The drosophila gap gene giant has an anterior segment identity function mediated through disconnected and teashirt
GENETICS, 179(1), 441–453.
MeSH headings : Animals; Body Patterning / genetics; DNA Primers / genetics; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / embryology; Gene Expression Regulation, Developmental / genetics; Microscopy, Confocal; Mutation / genetics; Repressor Proteins / genetics; Repressor Proteins / metabolism; Transcription Factors / metabolism
TL;DR:
The regulatory effects of gap genes on the spatial expression of disco, disco-r, and tsh during Drosophila embryogenesis are reported, shedding new light on how mutations in giant (gt) affect patterning within the anterior gt domain, demonstrating homeotic function in this domain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
The appendage role of insect disco genes and possible implications on the evolution of the maggot larval form
DEVELOPMENTAL BIOLOGY, 309(1), 56–69.
author keywords: drosophila; segment identity; zinc finger; appendage; limb; pattern formation
MeSH headings : Animals; Biological Evolution; Body Patterning; DNA-Binding Proteins / metabolism; Drosophila / embryology; Drosophila / growth & development; Drosophila / metabolism; Drosophila Proteins / metabolism; Head / embryology; Head / growth & development; Larva / growth & development; Larva / metabolism; Transcription Factors / metabolism; Tribolium / embryology; Tribolium / growth & development; Tribolium / metabolism
TL;DR:
It is proposed that the disco genes always function as appendage factors, but their appendage nature is masked during Drosophila embryogenesis due to the reduction of limb fields in the maggot style Drosophile larva.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Imaginal Discs, the Genetic and Cellular Logic of Pattern Formation. Lewis I Held, Jr. Cambridge University Press. 2005. 461 pages. ISBN 0 521 01835 8. Price £38. (paperback). (ISBN 0521 58445 0. Price £120. (hardback) published 2002)
Genetical Research, 87(3), 219–219.
Source: Crossref
Added: November 22, 2020
2005 review
Assisting Hox proteins in controlling body form: are there new lessons from flies (and mammals)?
[Review of ]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 15(4), 422–429.
MeSH headings : Amino Acid Sequence; Animals; Body Patterning / genetics; DNA-Binding Proteins / genetics; Diptera / embryology; Diptera / genetics; Gene Expression Regulation, Developmental; Homeodomain Proteins / genetics; Mice; Models, Genetic; Sequence Homology, Amino Acid; Zinc Fingers / genetics
TL;DR:
There is now evidence that a global network of zinc finger transcription factors contributes to patterning of the Drosophila embryo, and it is possible that these zinc finger proteins are Hox cofactors, providing additional specificity during Hox target-gene selection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
An interactive network of zinc-finger proteins contributes to regionalization of the Drosophila embryo and establishes the domains of HOM-C protein function
DEVELOPMENT, 131(12), 2781–2789.
author keywords: Hex; homeotic; zinc finger; Drosophila; segment identity; pattern formation
MeSH headings : Animals; Body Patterning / physiology; DNA-Binding Proteins / genetics; Drosophila Proteins / genetics; Drosophila melanogaster / embryology; Embryo, Nonmammalian / physiology; Gene Expression Regulation, Developmental / genetics; Homeodomain Proteins / genetics; Morphogenesis / physiology; Repressor Proteins / genetics; Transcription Factors / genetics; Zinc Fingers / physiology
TL;DR:
It is concluded that a combination of regionalizing factors, in concert with the HOM-C proteins, promotes the specification of individual segment identity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Expression of the Drosophila gene disconnected using the UAS/GAL4 system
GENESIS, 34(1-2), 103–106.
MeSH headings : Animals; Animals, Genetically Modified; Armadillo Domain Proteins; DNA Transposable Elements; DNA-Binding Proteins / biosynthesis; DNA-Binding Proteins / genetics; Drosophila Proteins / genetics; Drosophila melanogaster / embryology; Drosophila melanogaster / genetics; Enhancer Elements, Genetic; Eye / embryology; Female; Homeodomain Proteins / genetics; Male; Mutation; Saccharomyces cerevisiae Proteins / genetics; Trans-Activators / genetics; Transcription Factors / biosynthesis; Transcription Factors / genetics
TL;DR:
Three UAS-disco constructs were generated—two encoding wildtype proteins and one producing an altered protein like that encoded by the disco null allele, which causes embryonic lethality and the absence of some larval mouth structures arising from the gnathocephalic segments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
The drosophila genes disconnected and disco-related are redundant with respect to larval head development and accumulation of mRNAs from deformed target genes
Genetics, 157(1), 225–236.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Regulation by homeoproteins: A comparison of deformed- responsive elements
Genetics, 156(2), 677–686.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Using RNAi to investigate orthologous homeotic gene function during development of distantly related insects
Evolution and Development, 1(1), 11–15.
MeSH headings : Animals; Drosophila / embryology; Drosophila / genetics; Drosophila / growth & development; Genes, Homeobox; Mutation; RNA, Double-Stranded / physiology
TL;DR:
It is shown that RNA interference can be used to phenocopy mutations of the Deformed orthologues in Drosophila and Tribolium and the possible use of this technique is discussed for comparisons of developmental mechanisms in organisms with differing ontogenies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
1998 journal article
A family of Drosophila genes encoding quaking-related maxi-KH domains
BIOCHEMICAL GENETICS, 36(1-2), 51–64.
author keywords: Drosophila genetics; K homology domains; STAR proteins; nucleic acid-binding motifs
MeSH headings : Amino Acid Sequence; Animals; Chromosome Mapping; DNA-Binding Proteins / genetics; Drosophila / genetics; Drosophila Proteins; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Genes, Insect; Mice; Molecular Sequence Data; Multigene Family; Nuclear Proteins; Phosphoproteins / genetics; Phylogeny; Polymerase Chain Reaction / methods; RNA-Binding Proteins / genetics; Sequence Homology, Amino Acid
TL;DR:
Nine genes that specify a STAR (signal transduction and RNA activation) proteinexpressed within mesoderm and muscles are recovered, suggesting that maxi-KH domains are employed widely in Drosophila.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
A Drosophila muscle-specific gene related to the mouse quaking locus
GENE, 197(1-2), 315–323.
author keywords: muscle; mesoderm; Drosophila genetics; nucleic acid binding protein; KH domain
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Caenorhabditis elegans Proteins; Cell Differentiation; Chromosome Mapping; Cloning, Molecular; DNA, Complementary / genetics; Drosophila Proteins; Drosophila melanogaster / embryology; Drosophila melanogaster / genetics; Gene Expression Regulation, Developmental; Genes, Insect / genetics; Helminth Proteins / genetics; Mesoderm / chemistry; Mice; Molecular Sequence Data; Multigene Family / genetics; Muscles / chemistry; Muscles / cytology; Nuclear Proteins; RNA, Messenger / analysis; RNA-Binding Proteins / genetics; Sequence Homology, Amino Acid
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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