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2023 article
Defining the relevance of surgical margins. Part two: Strategies to improve prediction of recurrence risk
Bray, J., Eward, W., & Breen, M. (2023, February 15). VETERINARY AND COMPARATIVE ONCOLOGY.
2023 journal article
Dirofilaria immitis Identified in Galapagos Sea Lions (Zalophus wollebaeki): A Wildlife Health and Conservation Concern
JOURNAL OF WILDLIFE DISEASES, 59(3), 487–494.
2023 journal article
The dogs of Chernobyl: Demographic insights into populations inhabiting the nuclear exclusion zone
SCIENCE ADVANCES, 9(9).
2023 journal article
Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation: Short in-frame deletions in BRAF and MAP2K1 suggest alternative mechanisms for MAPK pathway disruption
PLOS GENETICS, 19(4).
2022 article
Evaluating the relevance of surgical margins. Part one: The problems with current methodology
Bray, J., Eward, W., & Breen, M. (2022, November 25). VETERINARY AND COMPARATIVE ONCOLOGY.
2022 article
Inter-pathologist agreement on diagnosis, classification and grading of canine glioma
Krane, G. A., Shockley, K. R., Malarkey, D. E., Miller, A. D., Miller, C. R., Tokarz, D. A., … Mariani, C. L. (2022, July 30). VETERINARY AND COMPARATIVE ONCOLOGY, Vol. 7.
2022 journal article
The AGMK1-9T7 cell model of neoplasia: Evolution of DNA copy-number aberrations and miRNA expression during transition from normal to metastatic cancer cells
PLOS ONE, 17(10).
2022 article
Transcriptome annotation reveals minimal immunogenetic diversity among Wyoming toads, Anaxyrus baxteri
Carlson, K. B., Wcisel, D. J., Ackerman, H. D., Romanet, J., Christiansen, E. F., Niemuth, J. N., … Yoder, J. A. (2022, April 28). CONSERVATION GENETICS, Vol. 4.
2021 article
Comparative Assessment of Pesticide Exposures in Domestic Dogs and Their Owners Using Silicone Passive Samplers and Biomonitoring
Wise, C. F., Hammel, S. C., Herkert, N. J., Ospina, M., Calafat, A. M., Breen, M., & Stapleton, H. M. (2021, December 29). ENVIRONMENTAL SCIENCE & TECHNOLOGY.
2021 journal article
Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions
MOLECULAR CANCER RESEARCH, 19(5), 847–861.
2021 article
Hi-C scaffolded short- and long-read genome assemblies of the California sea lion are broadly consistent for syntenic inference across 45 million years of evolution
Peart, C. R., Williams, C., Pophaly, S. D., Neely, B. A., Gulland, F. M. D., Adams, D. J., … Wolf, J. B. W. (2021, June 27). MOLECULAR ECOLOGY RESOURCES.
2021 journal article
Phase I/II Trial of Vemurafenib in Dogs with Naturally Occurring, BRAF-mutated Urothelial Carcinoma
MOLECULAR CANCER THERAPEUTICS, 20(11), 2177–2188.
2021 journal article
Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species
PLOS COMPUTATIONAL BIOLOGY, 17(9).
2020 article
A comparative oncology approach to biomarker and drug discovery for cancer diagnosis and treatment in dogs and humans
LeBlanc, A. K., Mazcko, C. N., Breen, M., Thomas, R., & Thamm, D. H. (2020, August). CANCER RESEARCH, Vol. 80.
2020 journal article
Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(12), 7409–7419.
2020 journal article
Development of a Genome-Wide Oligonucleotide Microarray Platform for Detection of DNA Copy Number Aberrations in Feline Cancers
VETERINARY SCIENCES, 7(3).
2020 article
Molecular mechanisms that activate convergent oncogenic pathway in genomically complex angiosarcoma
Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Schulte, A. J., Wang, C., … Modiano, J. F. (2020, August). CANCER RESEARCH, Vol. 80.
2020 journal article
PTPN11mutations in canine and human disseminated histiocytic sarcoma
INTERNATIONAL JOURNAL OF CANCER, 147(6), 1657–1665.
2020 journal article
Use of standardized bioinformatics for the analysis of fungal DNA signatures applied to sample provenance
FORENSIC SCIENCE INTERNATIONAL, 310.
2019 journal article
Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma
MOLECULAR CANCER RESEARCH, 17(12), 2410–2421.
2019 journal article
Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex
CHROMOSOME RESEARCH, 27(3), 179–202.
2019 journal article
Lack of influence by endosymbiont Wolbachia on virus titer in the common bed bug, Cimex lectularius
Parasites & Vectors, 12(1).
2019 journal article
Novel Noninvasive Diagnostics
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 49(5), 781-+.
2018 journal article
A comprehensive genomic history of extinct and living elephants
Proceedings of the National Academy of Sciences, 115(11), E2566–E2574.
2018 article
Comparative genomic analyses of osteosarcoma etiology reveal a chromosomal structural rationale for the increased incidence of osteosarcoma in dogs
Sarver, A. L., Mills, L., Temiz, N., Scott, M. I., Sarver, A., Spector, L., … Largaespada, D. (2018, July). CANCER RESEARCH, Vol. 78.
2018 journal article
Growth kinetics of endosymbiont Wolbachia in the common bed bug, Cimex lectularius
Scientific Reports, 8(1).
2018 article
Mutational and transcriptomic profiling identify distinct angiogenic and inflammatory subtypes of angiosarcoma
Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Wang, C., Elvers, I., … Modiano, J. F. (2018, July). CANCER RESEARCH, Vol. 78.
2018 journal article
Relationship Between Sequence Homology, Genome Architecture, and Meiotic Behavior of the Sex Chromosomes in North American Voles
GENETICS, 210(1), 83–97.
2018 journal article
Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis
PLOS GENETICS, 14(9).
2017 journal article
Association of breed and histopathological grade in canine mast cell tumours
VETERINARY AND COMPARATIVE ONCOLOGY, 15(3), 829–839.
2017 journal article
Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies
LEUKEMIA & LYMPHOMA, 58(7), 1702–1710.
2017 journal article
Evaluation of gene expression and DNA copy number profiles of adipose tissue-derived stromal cells and consecutive neurosphere-like cells generated from dogs with naturally occurring spinal cord injury
American Journal of Veterinary Research, 78(3), 371–380.
2017 journal article
Generation of LIF-independent induced pluripotent stem cells from canine fetal fibroblasts
Theriogenology, 92, 75–82.
2017 journal article
Genomic profiling of canine mast cell tumors identifies DNA copy number aberrations associated with KIT mutations and high histological grade
CHROMOSOME RESEARCH, 25(2), 129–143.
2017 journal article
Integrated immunohistochemical and DNA copy number profiling analysis provides insight into the molecular pathogenesis of canine follicular lymphoma
VETERINARY AND COMPARATIVE ONCOLOGY, 15(3), 852–867.
2017 journal article
Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma
VETERINARY AND COMPARATIVE ONCOLOGY, 15(2), 315–327.
2017 journal article
Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy
Journal of Cellular and Molecular Medicine, 21(8), 1503–1512.
2017 journal article
Malignant canine mammary tumours: Preliminary genomic insights using oligonucleotide array comparative genomic hybridisation analysis
VETERINARY JOURNAL, 222, 68–71.
2017 journal article
Sequence analysis of RAS and RAF mutation hot spots in canine carcinoma
VETERINARY AND COMPARATIVE ONCOLOGY, 15(4), 1598–1605.
2016 journal article
Comprehensive genomic characterization of five canine lymphoid tumor cell lines
BMC Veterinary Research, 12.
2016 journal article
Detection of Copy Number Imbalance in Canine Urothelial Carcinoma With Droplet Digital Polymerase Chain Reaction
VETERINARY PATHOLOGY, 53(4), 764–772.
2015 journal article
A novel canine kidney cell line model for the evaluation of neoplastic development: karyotype evolution associated with spontaneous immortalization and tumorigenicity
CHROMOSOME RESEARCH, 23(4), 663–680.
2015 journal article
BRAF Mutations in Canine Cancers
PLOS ONE, 10(6).
Contributors: H. Mochizuki n , K. Kennedy n, S. Shapiro n & n
2015 journal article
Canine urothelial carcinoma: genomically aberrant and comparatively relevant
Chromosome Research, 23(2), 311–331.
2015 journal article
Comparative cytogenetic characterization of primary canine melanocytic lesions using array CGH and fluorescence in situ hybridization
CHROMOSOME RESEARCH, 23(2), 171–186.
2015 review
Comparative oncology: what dogs and other species can teach us about humans with cancer
2015 journal article
Detection of BRAF Mutation in Urine DNA as a Molecular Diagnostic for Canine Urothelial and Prostatic Carcinoma
PLOS ONE, 10(12).
Contributors: H. Mochizuki n , S. Shapiro n & n
2015 journal article
Genome-wide assessment of recurrent genomic imbalances in canine leukemia identifies evolutionarily conserved regions for subtype differentiation
Chromosome Research, 23(4), 681–708.
2015 article
Peto's paradox and the promise of comparative oncology
Nunney, L., Maley, C. C., Breen, M., Hochberg, M. E., & Schiffman, J. D. (2015, July 19). PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol. 370.
2014 journal article
Canine Prostate Cancer Cell Line (Probasco) Produces Osteoblastic Metastases In Vivo
PROSTATE, 74(13), 1251–1265.
2014 journal article
Definition of the Cattle Killer Cell Ig-like Receptor Gene Family: Comparison with Aurochs and Human Counterparts
JOURNAL OF IMMUNOLOGY, 193(12), 6016–6030.
2014 journal article
Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma
CHROMOSOME RESEARCH, 22(3), 305–319.
2014 journal article
Identification of Three Molecular and Functional Subtypes in Canine Hemangiosarcoma through Gene Expression Profiling and Progenitor Cell Characterization
AMERICAN JOURNAL OF PATHOLOGY, 184(4), 985–995.
2013 journal article
Gene selection and cancer type classification of diffuse large-B-cell lymphoma using a bivariate mixture model for two-species data
Human Genomics, 7.
2013 journal article
Growth Requirements and Chromosomal Instability of Induced Pluripotent Stem Cells Generated from Adult Canine Fibroblasts
Stem Cells and Development, 22(6), 951–963.
2013 journal article
Molecular characterization of canine BCR-ABL-positive chronic myelomonocytic leukemia before and after chemotherapy
Veterinary Clinical Pathology, 42(3), 314–322.
2013 article
Naturally occuring canine cancers: powerful models for stimulating pharmacogenomic advancement in human medicine
Rotroff, D. M., Thomas, R., Breen, M., & Motsinger-Reif, A. A. (2013, December). PHARMACOGENOMICS, Vol. 14, pp. 1929–1931.
2013 journal article
Partial cytogenetic response with toceranib and prednisone treatment in a young dog with chronic monocytic leukemia
ANTI-CANCER DRUGS, 24(10), 1098–1103.
2012 journal article
A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations
Cancer Genetics, 205(11), 572–587.
2012 journal article
Acute myeloblastic leukemia with associated BCR-ABL translocation in a dog
VETERINARY CLINICAL PATHOLOGY, 41(3), 362–368.
2012 journal article
Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas
Cancer, 118(23), 5878–5887.
2012 journal article
Array-based comparative genomic hybridization-guided identification of reference genes for normalization of real-time quantitative polymerase chain reaction assay data for lymphomas, histiocytic sarcomas, and osteosarcomas of dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(9), 1335–1343.
2012 journal article
CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies
LEUKEMIA & LYMPHOMA, 53(7), 1390–1398.
2012 conference paper
Generation and characterization of induced pluripotent stem cells (iPS) from adult canine fibroblasts
Reproduction in Domestic Animals, 47, 418–419.
2012 journal article
Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma
BONE, 50(1), 171–181.
2012 journal article
The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification
GENES CHROMOSOMES & CANCER, 51(6), 569–578.
2011 journal article
Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes
CHROMOSOME RESEARCH, 19(6), 685–708.
2011 journal article
BCR-ABL translocation in a dog with chronic monocytic leukemia
VETERINARY CLINICAL PATHOLOGY, 40(1), 40–47.
2011 journal article
Characterization of Canine Osteosarcoma by Array Comparative Genomic Hybridization and RT-qPCR: Signatures of Genomic Imbalance in Canine Osteosarcoma Parallel the Human Counterpart
GENES CHROMOSOMES & CANCER, 50(11), 859–874.
2011 journal article
Development of a Brain Metastatic Canine Prostate Cancer Cell Line
PROSTATE, 71(12), 1251–1263.
2011 journal article
FLT3 mutations in canine acute lymphocytic leukemia
BMC CANCER, 11.
2011 journal article
Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach
BONE, 49(3), 356–367.
2011 journal article
Reading between the lines: molecular characterization of five widely used canine lymphoid tumour cell lines
Veterinary and Comparative Oncology, 11(1), 30–50.
2011 journal article
Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas
Leukemia & Lymphoma, 52(7), 1321–1335.
2011 journal article
The genome of the green anole lizard and a comparative analysis with birds and mammals
Nature, 477(7366), 587–591.
2010 journal article
Mature Hair Follicles Generated from Dissociated Cells: A Universal Mechanism of Folliculoneogenesis
DEVELOPMENTAL DYNAMICS, 239(10), 2619–2626.
2010 journal article
Predicting Residential Air Exchange Rates from Questionnaires and Meteorology: Model Evaluation in Central North Carolina
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 44(24), 9349–9356.
2009 journal article
Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by microarray-based CGH analysis
CHROMOSOME RESEARCH, 17(7), 927–934.
2009 journal article
Generation and characterization of novel canine malignant mast cell line CL1
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 127(1-2), 114–124.
2009 journal article
IDH1 and IDH2 hotspot mutations are not found in canine glioma
International Journal of Cancer, 127(1), 245–246.
2009 journal article
Influence of genetic background on tumor karyotypes: Evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma
CHROMOSOME RESEARCH, 17(3), 365–377.
2009 journal article
Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas
CHROMOSOME RESEARCH, 17(8), 987–1000.
2009 journal article
ORIGINS AND EVOLUTION OF A TRANSMISSIBLE CANCER
EVOLUTION, 63(9), 2340–2349.
2009 review
Update on Genomics in Veterinary Oncology
[Review of ]. TOPICS IN COMPANION ANIMAL MEDICINE, 24(3), 113–121.
2009 journal article
‘Putting our heads together’: insights into genomic conservation between human and canine intracranial tumors
Journal of Neuro-Oncology, 94(3), 333–349.
2008 journal article
A genome assembly-integrated dog 1 Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysis
CYTOGENETIC AND GENOME RESEARCH, 122(2), 110–121.
2008 article
Canine cytogenetics - from band to basepair
CYTOGENETIC AND GENOME RESEARCH, Vol. 120, pp. 50–60.
2008 journal article
Enhancement of extra chromosomal recombination in somatic cells by affecting the ratio of homologous recombination (HR) to non-homologous end joining (NHEJ)
ANIMAL BIOTECHNOLOGY, 19(1), 6–21.
2008 journal article
Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans - man and his best friend share more than companionship
CHROMOSOME RESEARCH, 16(1), 145–154.
2008 journal article
Tackling the characterization of canine chromosomal breakpoints with an integrated in-situ/in-silico approach: The canine PAR and PAB
CHROMOSOME RESEARCH, 16(8), 1193–1202.
2007 article
A cytogenetically characterized, genome-anchored 10-Mb BAC set and CGH array for the domestic dog
JOURNAL OF HEREDITY, Vol. 98, pp. 474–484.
2007 journal article
A novel canine lymphoma cell line: A translational and comparative model for lymphoma research
LEUKEMIA RESEARCH, 31(12), 1709–1720.
2007 review
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
[Review of ]. NATURE, 447(7141), 167–U1.
2007 journal article
Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-Cell lymphoma
VETERINARY PATHOLOGY, 44(4), 467–478.
2007 journal article
Integrated cytogenetic BAC map of the genome of the gray, short-tailed opossum, Monodelphis domestica
CHROMOSOME RESEARCH, 15(3), 361–370.
2007 journal article
Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphoma
Leukemia, 21(1), 184–187.
2007 journal article
The search for a marsupial XIC reveals a break with vertebrate synteny
Chromosome Research, 15(2), 137–146.
2006 personal communication
The dog as a cancer model
Khanna, C., Lindblad-Toh, K., Vail, D., London, C., Bergman, P., Barber, L., … Withrow, S. (2006, September).
2005 journal article
Genome sequence, comparative analysis and haplotype structure of the domestic dog
Nature, 438(7069), 803–819.
2004 journal article
A high-resolution comparative map of canine Chromosome 5q14.3–q33 constructed utilizing the 1.5× canine genomesequence
Mammalian Genome, 15(7), 544–551.
2004 journal article
Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium
Laboratory Investigation, 84(5), 562–572.
journal article
A comprehensive genomic history of extinct and living elephants
Palkopoulou, E., Lipson, M., Mallick, S., Nielsen, S., Rohland, N., Baleka, S., … Meller, H. Proceedings of the National Academy of Sciences of the United States of America, 115(11), E2566–2574.
journal article
Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients
LeBlanc, A. K., Mazcko, C., Brown, D. E., Koehler, J. W., Miller, A. D., Miller, C. R., … Dickinson, P. J. Neuro-Oncology, 18(9), 1209–1218.
journal article
Cytogenetic BAC map of the genome of Monodelphis domestica
Duke, S. E., Samallow, P., Mauceli, E., Lindblad-Toh, K., & Breen, M. Chromosome Research, 15, 3610–3670.
journal article
Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background
Elvers, I., Turner-Maier, J., Swofford, R., Koltookian, M., Johnson, J., Stewart, C., … Lindblad-Toh, K. Genome Research, 25(11), 1634–1645.
review
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
Mikkelsen, T. S., Wakefield, M. J., Aken, B., Amemiya, C. T., Chang, J. L., Duke, S., … al. [Review of ]. 254, 447(7141), 167–161.
journal article
Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B
Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Rivera, P. Genome Biology, 14(12).
journal article
Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers
Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Kim, J. H. PLoS Genetics, 11(2).
journal article
Molecular profiling reveals prognostically significant subtypes of canine lymphoma
Frantz, A. M., Sarver, A. L., Ito, D., Phang, T. L., Karimpour-Fard, A., Scott, M. C., … O'Brien, T. D. Veterinary Pathology, 50(4), 693–703.
journal article
Naturally occurring translational models for development of cancer gene therapy
Modiano, J. F., Breen, M., Lana, S. E., Ehrhart, N., Fosmire, S. P., Thomas, R., … Bellgrau, D. Gene Therapy & Molecular Biology, 10A, 31–40.
journal article
Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology
LeBlanc, A. K., Breen, M., Choyke, P., Dewhirst, M., Fan, T. M., Gustafson, D. L., … Trent, J. M. Science Translational Medicine, 8(324).
personal communication
Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphoma
Modiano, J. F., Breen, M., O Valli, V. E., Wojcieszyn, J. W., & Cutter, G. R.
journal article
SETD2 is recurrently mutated in whole-exome sequenced canine osteosarcoma
Sakthikumar, S., Elvers, I., Kim, J., Arendt, M. L., Thomas, R., Turner-Maier, J., … Modiano, J. F. Cancer Research, 78(13), 3421–3431.
journal article
Safe and effective sarcoma therapy through bispecific targeting of EGFR and uPAR
Borgatti, A., Koopmeiners, J. S., Sarver, A. L., Winter, A. L., Stuebner, K., Todhunter, D., … Oh, F. Molecular Cancer Therapeutics, 16(5), 956–965.
journal article
The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer
Shearin, A. L., Hedan, B., Cadieu, E., Erich, S. A., Schmidt, E. V., Faden, D. L., … Andre, C. Cancer Epidemiology Biomarkers, 21(7), 1019–1027.
journal article
The genome of the green anole lizard and a comparative analysis with birds and mammals
Alfoldi, J., Di Palma, F., Grabherr, M., Williams, C., Kong, L. S., Mauceli, E., … Moreno, R. G. Nature, 477(7366), 587–591.
journal article
Three crocodilian genomes reveal ancestral patterns of evolution among archosaurs
Green, R. E., Braun, E. L., Armstrong, J., Earl, D., Nguyen, N., Hickey, G., … Hubley, R. M. Science, 346(6215), 1335-.