Works (118)

Updated: April 20th, 2024 05:00

2024 journal article

The development of non-destructive sampling methods of parchment skins for genetic species identification

PLOS ONE, 19(3).

By: M. Scheible*, T. Stinson*, M. Breen*, B. Callahan*, R. Thomas* & K. Meiklejohn*

Ed(s): A. Shakoori

TL;DR: A workflow for enriching the mitochondrial genome (mtGenome), generating next-generation sequencing reads to permit species identification, and providing interpretation guidance is defined, defining a workflow for enriching the mitochondrial genome, generating next-generation sequencing reads to permit species identification, and providing interpretation guidance. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 22, 2024

2023 article

Defining the relevance of surgical margins. Part two: Strategies to improve prediction of recurrence risk

Bray, J., Eward, W., & Breen, M. (2023, February 15). VETERINARY AND COMPARATIVE ONCOLOGY.

By: J. Bray, W. Eward* & M. Breen n

author keywords: genetics; pathology; small animal; surgical oncology; tumour biology
MeSH headings : Animals; Cats; Dogs; Margins of Excision; Neoplasm, Residual / pathology; Neoplasm, Residual / veterinary; Cat Diseases / surgery; Neoplasm Recurrence, Local / veterinary; Dog Diseases / surgery
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 13, 2023

2023 journal article

Dirofilaria immitis Identified in Galapagos Sea Lions (Zalophus wollebaeki): A Wildlife Health and Conservation Concern

JOURNAL OF WILDLIFE DISEASES, 59(3), 487–494.

By: T. Gregory n, I. Livingston n, E. Hawkins n, A. Loyola*, A. Cave n, S. Vaden n, D. Deresienski n, M. Breen n ...

author keywords: Dirofilaria immitis; Galapagos Islands; heartworm; Zalophus wollebaeki
MeSH headings : Animals; Dogs; Male; Sea Lions; Dirofilaria immitis; Animals, Wild; Caniformia; Animals, Domestic; Endangered Species; Dirofilariasis / epidemiology; Dog Diseases
TL;DR: This is the first report of D. immitis infection in Galapagos sea lions, and widespread adoption of routine heartworm testing, prevention, and treatment in the canine population, and the control of mosquitos, could potentially reduce the disease impact on this endangered pinniped species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 14, 2023

2023 journal article

The dogs of Chernobyl: Demographic insights into populations inhabiting the nuclear exclusion zone

SCIENCE ADVANCES, 9(9).

MeSH headings : Dogs; Animals; Chernobyl Nuclear Accident; Environment; Disasters; Environmental Pollution; Demography
TL;DR: This study presents the first characterization of a domestic species in Chernobyl, establishing their importance for genetic studies into the effects of exposure to long-term, low-dose ionizing radiation. (via Semantic Scholar)
Source: Web Of Science
Added: April 4, 2023

2023 journal article

Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation: Short in-frame deletions in BRAF and MAP2K1 suggest alternative mechanisms for MAPK pathway disruption

PLOS GENETICS, 19(4).

By: R. Thomas n, C. Wiley n, E. Droste n, J. Robertson n, B. Inman* & M. Breen n

Ed(s): T. Leeb

MeSH headings : Dogs; Animals; Humans; Urinary Bladder Neoplasms / genetics; Urinary Bladder Neoplasms / veterinary; Carcinoma, Transitional Cell / genetics; Carcinoma, Transitional Cell / veterinary; Proto-Oncogene Proteins B-raf / genetics; Exome Sequencing; Mutation; MAP Kinase Kinase 1 / genetics
TL;DR: It is suggested that short in-frame deletions within BRAF exon 12 and MAP2K1 exons 2 and 3 in UDV595E cases are alternative MAPK-pathway activating events that may have significant therapeutic implications for selecting first-line treatment for canine UC. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 15, 2023

2022 article

Evaluating the relevance of surgical margins. Part one: The problems with current methodology

Bray, J., Eward, W., & Breen, M. (2022, November 25). VETERINARY AND COMPARATIVE ONCOLOGY.

By: J. Bray, W. Eward* & M. Breen n

author keywords: genetics'; pathology; small animal; surgical oncology; tumour biology
MeSH headings : Animals; Margins of Excision; Neoplasm Recurrence, Local / veterinary; Retrospective Studies
TL;DR: The challenges with defining the true extent of the tumours margin from the perspective of the surgeon, the pathologist and the tumour are described and why current efforts to ensure that all traces of the local tumour have been successfully removed may provide an imperfect assessment of the risk of recurrence. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: December 12, 2022

2022 article

Inter-pathologist agreement on diagnosis, classification and grading of canine glioma

Krane, G. A., Shockley, K. R., Malarkey, D. E., Miller, A. D., Miller, C. R., Tokarz, D. A., … Mariani, C. L. (2022, July 30). VETERINARY AND COMPARATIVE ONCOLOGY, Vol. 7.

By: G. Krane n, K. Shockley*, D. Malarkey*, A. Miller*, C. Miller*, D. Tokarz n, H. Jensen*, K. Janardhan*, M. Breen n, C. Mariani n

author keywords: brain; cancer; dog; histopathology; immunohistochemistry
MeSH headings : Humans; Animals; Dogs; Oligodendroglioma / diagnosis; Oligodendroglioma / veterinary; Oligodendroglioma / pathology; Pathologists; Dog Diseases / diagnosis; Dog Diseases / pathology; Glioma / diagnosis; Glioma / veterinary; Glioma / pathology; Astrocytoma / veterinary; Brain Neoplasms / diagnosis; Brain Neoplasms / veterinary; Brain Neoplasms / pathology
TL;DR: Inter‐pathologist agreement utilising CBTC guidelines for canine glioma was moderate overall but varied from fair to almost perfect between pairs of pathologists, similar for oligodendrogliomas and astrocytomas but lower for undefined gliomas. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 8, 2022

2022 journal article

The AGMK1-9T7 cell model of neoplasia: Evolution of DNA copy-number aberrations and miRNA expression during transition from normal to metastatic cancer cells

PLOS ONE, 17(10).

By: A. Lewis*, R. Thomas*, M. Breen*, K. Peden*, B. Teferedegne*, G. Foseh*, A. Motsinger-Reif n, D. Rotroff n, G. Lewis

MeSH headings : Animals; Humans; Chlorocebus aethiops; MicroRNAs / genetics; MicroRNAs / metabolism; Neoplasms / genetics; Carcinogenesis / genetics; DNA Copy Number Variations / genetics; Chromosome Aberrations; Neoplasms, Second Primary / genetics; DNA; Gene Expression Regulation, Neoplastic; Gene Expression Profiling
TL;DR: The evolution of chromosomal DNA copy-number aberrations and miRNA expression in this cell line from passage 1 to the acquisition of a tumorigenic phenotype at passage 40 is examined and it is proposed that the evolution of AGMK1-9T7 cells represents a detailed model of neoplasia in vitro. (via Semantic Scholar)
Source: Web Of Science
Added: February 27, 2023

2022 article

Transcriptome annotation reveals minimal immunogenetic diversity among Wyoming toads, Anaxyrus baxteri

Carlson, K. B., Wcisel, D. J., Ackerman, H. D., Romanet, J., Christiansen, E. F., Niemuth, J. N., … Yoder, J. A. (2022, April 28). CONSERVATION GENETICS, Vol. 4.

By: K. Carlson n, D. Wcisel n, H. Ackerman n, J. Romanet n, E. Christiansen n, J. Niemuth n, C. Williams n, M. Breen n ...

author keywords: Amphibian; Bufonidae; Immunogenetics; MHC; TLR; Transcriptomics
TL;DR: Comparison transcriptomics is used to examine the diversity of toll-like receptors and major histocompatibility complex sequences across three individual Wyoming toads and finds reduced diversity at MHC genes compared to bufonid species with a similar history of bottleneck events. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 29, 2022

2021 article

Comparative Assessment of Pesticide Exposures in Domestic Dogs and Their Owners Using Silicone Passive Samplers and Biomonitoring

Wise, C. F., Hammel, S. C., Herkert, N. J., Ospina, M., Calafat, A. M., Breen, M., & Stapleton, H. M. (2021, December 29). ENVIRONMENTAL SCIENCE & TECHNOLOGY.

author keywords: exposure; wristband; silicone; biomonitoring; pesticide; dog
MeSH headings : Animals; Biological Monitoring; Chlorpyrifos; Dogs; Environmental Exposure / analysis; Environmental Monitoring; Humans; Pesticides / analysis; Silicones
TL;DR: It is suggested that people and their dogs have similar pesticide exposures in a home environment as well as targeted gas chromatography-mass spectrometry analyses suggest. (via Semantic Scholar)
Source: Web Of Science
Added: January 18, 2022

2021 journal article

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions

MOLECULAR CANCER RESEARCH, 19(5), 847–861.

By: J. Kim*, K. Megquier*, R. Thomas n, A. Sarver*, J. Song*, Y. Kim*, N. Cheng*, A. Schulte* ...

MeSH headings : Animals; Dog Diseases / genetics; Dogs; Gene Expression Profiling / methods; Gene Fusion; Genomics / methods; Hemangiosarcoma / genetics; Humans; Transcription, Genetic; Vascular Neoplasms / genetics
TL;DR: While drive events of malignant vasoformative tumors of humans and dogs include diverse mutations and stochastic rearrangements that create novel fusion genes, convergent transcriptional programs govern the highly conserved morphologic organization and biological behavior of these tumors in both species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 10, 2021

2021 article

Hi-C scaffolded short- and long-read genome assemblies of the California sea lion are broadly consistent for syntenic inference across 45 million years of evolution

Peart, C. R., Williams, C., Pophaly, S. D., Neely, B. A., Gulland, F. M. D., Adams, D. J., … Wolf, J. B. W. (2021, June 27). MOLECULAR ECOLOGY RESOURCES.

author keywords: California sea lion (Zalophus californianus); cancer; Carnivora; chromatin interaction mapping; genome assembly; genome evolution; Hi-C
MeSH headings : Animals; Dogs; Ferrets; Genome; Sea Lions / genetics; Synteny; X Chromosome
TL;DR: This study presents high-quality genomes of an emerging cancer model and highlights that even highly fragmented short-read assemblies scaffolded with Hi-C can yield reliable chromosome level scaffolds suitable for comparative genomic analyses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: July 6, 2021

2021 journal article

Phase I/II Trial of Vemurafenib in Dogs with Naturally Occurring, BRAF-mutated Urothelial Carcinoma

MOLECULAR CANCER THERAPEUTICS, 20(11), 2177–2188.

By: P. Rossman*, T. Zabka, A. Ruple*, D. Tuerck*, J. Ramos-Vara*, L. Liu, R. Mohallem*, M. Merchant ...

MeSH headings : Adolescent; Animals; Carcinoma, Transitional Cell / drug therapy; Carcinoma, Transitional Cell / pathology; Child; Disease Models, Animal; Dogs; Humans; Mutation; Proto-Oncogene Proteins B-raf / drug effects; Vemurafenib / pharmacology; Vemurafenib / therapeutic use
TL;DR: The safety, antitumor activity, and cutaneous pharmacodynamic effects of vemurafenib, and the development of drug resistance in dogs closely mimic those reported in humans, which suggests BRAF-mutated canine InvUC offers an important complementary animal model to improve BRAf-targeted therapies in humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 23, 2021

2021 journal article

Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species

PLOS COMPUTATIONAL BIOLOGY, 17(9).

MeSH headings : Animals; Biomarkers, Tumor / genetics; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Computational Biology; Dog Diseases / classification; Dog Diseases / genetics; Dogs; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Lung Neoplasms / genetics; Lung Neoplasms / veterinary; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / veterinary; Lymphoma, T-Cell / genetics; Lymphoma, T-Cell / veterinary; Melanoma / genetics; Melanoma / veterinary; Molecular Sequence Annotation; Molecular Targeted Therapy; Neoplasms / classification; Neoplasms / genetics; Neoplasms / veterinary; Oncogenes; Osteosarcoma / genetics; Osteosarcoma / veterinary; Species Specificity; Translational Research, Biomedical
TL;DR: An experimental-bioinformatic protocol is developed that analyzes canine transcriptomics data in the context of existing human data to evaluate comparative relevance of canine to human cancer, and demonstrates transferability of classification models from canines to humans. (via Semantic Scholar)
Source: Web Of Science
Added: February 21, 2022

2020 article

A comparative oncology approach to biomarker and drug discovery for cancer diagnosis and treatment in dogs and humans

LeBlanc, A. K., Mazcko, C. N., Breen, M., Thomas, R., & Thamm, D. H. (2020, August). CANCER RESEARCH, Vol. 80.

TL;DR: This work exemplifies the type of approach meant to further establish the comparative relevance of canine to human cancer and provide opportunities to explore hypotheses related to detection and treatment in both species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: March 8, 2021

2020 journal article

Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(12), 7409–7419.

MeSH headings : Animals; Biomarkers; Dogs; Environmental Monitoring; Humans; Organophosphates; Silicones
TL;DR: Exposures among pet dogs and their owners using silicone dog tags and wristbands were evaluated to determine if contaminant levels were correlated with validated biomarkers and the value of using silicone bands with dogs to investigate health impacts on humans from shared exposures is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: July 13, 2020

2020 journal article

Development of a Genome-Wide Oligonucleotide Microarray Platform for Detection of DNA Copy Number Aberrations in Feline Cancers

VETERINARY SCIENCES, 7(3).

By: R. Thomas n, J. Pontius*, L. Borst n & M. Breen n

author keywords: feline; cat; cancer; genomics; chromosome; comparative genomic hybridization (CGH)
TL;DR: A microarray platform that allows rapid and sensitive detection of DNA copy number aberrations in feline tumors using comparative genomic hybridization analysis is developed and shown to have diverse potential to incorporate domestic cat cancers into comparative and translational research efforts in molecular oncology. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020

2020 article

Molecular mechanisms that activate convergent oncogenic pathway in genomically complex angiosarcoma

Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Schulte, A. J., Wang, C., … Modiano, J. F. (2020, August). CANCER RESEARCH, Vol. 80.

By: J. Kim*, K. Megquier*, A. Sarver*, R. Thomas n, A. Schulte*, C. Wang*, I. Elvers*, E. Karlsson* ...

TL;DR: The data suggests that genomic instability induced by TP53 mutations might create a predisposition for fusion events that may contribute to tumor progression by promoting selection and/or enhancing fitness through activation of convergent angiogenic pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: March 8, 2021

2020 journal article

PTPN11mutations in canine and human disseminated histiocytic sarcoma

INTERNATIONAL JOURNAL OF CANCER, 147(6), 1657–1665.

By: B. Hedan*, M. Rault*, J. Abadie*, R. Ulve*, N. Botherel*, P. Devauchelle, C. Copie-Bergman*, E. Cadieu* ...

author keywords: histiocytic sarcoma; dog; spontaneous model; PTPN11
MeSH headings : Adult; Aged; Aged, 80 and over; Animals; Biopsy; Cell Line, Tumor; Cell Proliferation / drug effects; Child; Child, Preschool; DNA Mutational Analysis; Disease Models, Animal; Dog Diseases / blood; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Drug Screening Assays, Antitumor / methods; Female; Histiocytes / pathology; Histiocytic Sarcoma / drug therapy; Histiocytic Sarcoma / genetics; Histiocytic Sarcoma / pathology; Histiocytic Sarcoma / veterinary; Humans; Infant; MAP Kinase Signaling System / drug effects; MAP Kinase Signaling System / genetics; Male; Middle Aged; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / metabolism; Mutation; Protein Kinase Inhibitors / pharmacology; Protein Kinase Inhibitors / therapeutic use; Protein Tyrosine Phosphatase, Non-Receptor Type 11 / antagonists & inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 11 / genetics; Ribonucleases; Tumor Suppressor Proteins; Young Adult
TL;DR: Results illustrate the relevance of naturally affected dogs in deciphering genetic mechanisms and selecting efficient targeted therapies for such rare and aggressive cancers in humans, by testing drugs targeting the MAPK pathway in eight canine HS cell lines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 10, 2020

2020 journal article

Use of standardized bioinformatics for the analysis of fungal DNA signatures applied to sample provenance

FORENSIC SCIENCE INTERNATIONAL, 310.

By: J. Allwood n, N. Fierer*, R. Dunn n, M. Breen n, B. Reich n, E. Laber n, J. Clifton n, N. Grantham n, S. Faith n

author keywords: Forensic microbiology; Bioinformatics; Metabarcoding; Sample provenance
MeSH headings : DNA Barcoding, Taxonomic; DNA, Fungal / chemistry; Demography; Forensic Sciences; Fungi; Humans; Reference Values; Soil
TL;DR: Investigating a small-scale approach as an adaptation of a larger metabarcoding study to develop a model for global sample provenance using fungal DNA signatures collected from dust swabs to facilitate a standardized method for consistent, reproducible sample treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020

2019 journal article

Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma

MOLECULAR CANCER RESEARCH, 17(12), 2410–2421.

By: K. Megquier*, J. Turner-Maier*, R. Swofford*, J. Kim*, A. Sarver*, C. Wang*, S. Sakthikumar*, J. Johnson* ...

MeSH headings : Animals; Blood Vessels / pathology; Breast / metabolism; Breast / pathology; Class I Phosphatidylinositol 3-Kinases / genetics; Class Ia Phosphatidylinositol 3-Kinase / genetics; Cyclin-Dependent Kinase Inhibitor p15 / genetics; Cyclin-Dependent Kinase Inhibitor p16 / genetics; Dogs; Female; Genome / genetics; Genomics; Hemangiosarcoma / genetics; Hemangiosarcoma / pathology; Humans; Mutation / genetics; Tumor Suppressor Protein p53 / genetics; Viscera / metabolism; Viscera / pathology; Exome Sequencing
TL;DR: Canine hemangiosarcoma closely models the genomic landscape of human angiosarComa of the breast and viscera, and is a powerful tool for investigating the pathogenesis of this devastating disease. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: December 30, 2019

2019 journal article

Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex

CHROMOSOME RESEARCH, 27(3), 179–202.

By: K. Kennedy n, R. Thomas n, J. Durrant n, T. Jiang n, A. Motsinger-Reif n & M. Breen n

author keywords: Histiocytic sarcoma; Chromothripsis; MMP9; Aurora kinase; Dendritic cell sarcoma
MeSH headings : Animals; Chromosome Disorders; DNA Copy Number Variations / genetics; Dog Diseases / diagnosis; Dog Diseases / genetics; Dogs; Gene Expression Profiling; Genome / genetics; Histiocytic Disorders, Malignant / diagnosis; Histiocytic Disorders, Malignant / genetics; Histiocytic Disorders, Malignant / veterinary; Humans; Immunohistochemistry / methods; Matrix Metalloproteinase 9 / metabolism; Spindle Apparatus / pathology
TL;DR: Droplet digital PCR evaluation of these regions in numerous cancer specimens effectively discriminated HM from other common round cell tumors, including lymphoma and hemangiosarcoma, resulting in a novel, rapid diagnostic aid for veterinary medicine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: Web Of Science
Added: September 30, 2019

2019 journal article

Lack of influence by endosymbiont Wolbachia on virus titer in the common bed bug, Cimex lectularius

Parasites & Vectors, 12(1).

By: M. Fisher n, J. Levine n, J. Guy n, H. Mochizuki n, M. Breen n, C. Schal n, D. Watson n

author keywords: Cimex lectularius; Wolbachia; Endosymbiont; Cimicidae; Virus suppression; ssRNA
MeSH headings : Animals; Bedbugs / microbiology; Bedbugs / virology; Calicivirus, Feline / growth & development; Calicivirus, Feline / isolation & purification; Microbial Interactions; Viral Load; Wolbachia / growth & development
TL;DR: It is suggested that other mechanisms are involved in virus suppression within bed bugs, independent of the influence of Wolbachia, and the need for future research is underscore. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 30, 2019

2019 journal article

Novel Noninvasive Diagnostics

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 49(5), 781-+.

By: C. Wiley n, C. Wise n & M. Breen n

author keywords: Canine; Cancer; Liquid biopsy; Bladder; Prostate; BRAF; Lymphoma
MeSH headings : Animals; Carcinoma, Transitional Cell / diagnosis; Carcinoma, Transitional Cell / genetics; Carcinoma, Transitional Cell / veterinary; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / genetics; Dogs; Early Detection of Cancer / methods; Early Detection of Cancer / veterinary; Female; Humans; Leukemia / diagnosis; Leukemia / veterinary; Liquid Biopsy / methods; Liquid Biopsy / veterinary; Lymphoma / diagnosis; Lymphoma / drug therapy; Lymphoma / veterinary; Male; Molecular Targeted Therapy / veterinary; Mutation; Neoplasms / diagnosis; Neoplasms / drug therapy; Neoplasms / genetics; Neoplasms / veterinary; Urethral Neoplasms / diagnosis; Urethral Neoplasms / genetics; Urethral Neoplasms / veterinary; Urinary Bladder Neoplasms / veterinary
TL;DR: Noninvasive/minimally invasive techniques have been described in veterinary medicine that could be referred to as liquid biopsy, which offer new opportunities for improving cancer screening, diagnosis, and monitoring the impact of therapy on the patients over time. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: September 16, 2019

2018 journal article

A comprehensive genomic history of extinct and living elephants

Proceedings of the National Academy of Sciences, 115(11), E2566–E2574.

By: E. Palkopoulou*, M. Lipson*, S. Mallick*, S. Nielsen*, N. Rohland*, S. Baleka*, E. Karpinski*, A. Ivancevic* ...

author keywords: paleogenomics; elephantid evolution; mammoth; admixture; species divergence
MeSH headings : Animals; Elephants / classification; Elephants / genetics; Evolution, Molecular; Extinction, Biological; Fossils; Gene Flow; Genome; Genomics / history; History, Ancient; Mammoths / classification; Mammoths / genetics; Mastodons / classification; Mastodons / genetics; Phylogeny
TL;DR: It is shown that interspecies hybridization has been a recurrent feature of elephantid evolution, and the genetic makeup of the straight-tusked elephant, previously placed as a sister group to African forest elephants based on lower coverage data, in fact comprises three major components. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Crossref
Added: February 21, 2020

2018 article

Comparative genomic analyses of osteosarcoma etiology reveal a chromosomal structural rationale for the increased incidence of osteosarcoma in dogs

Sarver, A. L., Mills, L., Temiz, N., Scott, M. I., Sarver, A., Spector, L., … Largaespada, D. (2018, July). CANCER RESEARCH, Vol. 78.

TL;DR: It is hypothesized that increased osteosarcoma incidence in dogs is partly due to a syntenic rearrangement of the peri-PTEN locus in the canine genome, which creates a high risk of loss in the context of cytogenetic instability caused by disruption of TP53, thereby providing a structural genetic rational for the higher incidence of osteosARcoma in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: June 24, 2019

2018 journal article

Growth kinetics of endosymbiont Wolbachia in the common bed bug, Cimex lectularius

Scientific Reports, 8(1).

By: M. Fisher n, D. Watson n, J. Osborne n, H. Mochizuki n, M. Breen n & C. Schal n

MeSH headings : Animals; Bedbugs / microbiology; DNA / genetics; Female; Kinetics; Larva / microbiology; Symbiosis; Wolbachia / growth & development
TL;DR: It is highlighted that wCle is dynamic during bed bug development, changing relative to life stage, intermolt stage, and blood-fed status, and the observed quantitative modulation of wCle during the bed bug life cycle and during periods of starvation may explain the disparities in wCle infections reported in field-collected C. lectularius. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: December 30, 2019

2018 article

Mutational and transcriptomic profiling identify distinct angiogenic and inflammatory subtypes of angiosarcoma

Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Wang, C., Elvers, I., … Modiano, J. F. (2018, July). CANCER RESEARCH, Vol. 78.

Source: Web Of Science
Added: June 24, 2019

2018 journal article

Relationship Between Sequence Homology, Genome Architecture, and Meiotic Behavior of the Sex Chromosomes in North American Voles

GENETICS, 210(1), 83–97.

By: B. Dumont n, C. Williams n, B. Ng*, V. Horncastle*, C. Chambers*, L. McGraw n, D. Adams*, T. Mackay n, M. Breen n

author keywords: pseudoautosomal region; Microtus heterochromatin; telomeric repeats; meiotic synapsis
MeSH headings : Animals; Arvicolinae / genetics; Chromosome Segregation / genetics; Genomics / methods; Meiosis / genetics; North America; Pseudoautosomal Regions / genetics; Sequence Analysis, DNA / methods; Sequence Homology, Nucleic Acid; Sex Chromosomes / genetics; Telomere / genetics; Telomere-Binding Proteins / genetics; X Chromosome / genetics; Y Chromosome / genetics
TL;DR: Key conditions required to sustain the standard program of X/Y synapsis at meiosis are suggested and an intriguing connection between heterochromatic repeat architecture and noncanonical, asynaptic mechanisms of sex chromosome segregation in voles is revealed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis

PLOS GENETICS, 14(9).

By: W. Hendricks*, V. Zismann*, K. Sivaprakasam*, C. Legendre*, K. Poorman n, W. Tembe*, N. Perdigones*, J. Kiefer* ...

TL;DR: The genomic landscape of canine melanoma is mapped through multi-platform analysis of 37 tumors and matching constitutional samples and identifies novel predominantly truncating mutations in the putative tumor suppressor gene PTPRJ, which resembles that seen in BRAF wild-type and sun-shielded human melanoma subtypes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 16, 2018

2017 journal article

Association of breed and histopathological grade in canine mast cell tumours

VETERINARY AND COMPARATIVE ONCOLOGY, 15(3), 829–839.

By: H. Mochizuki n, A. Motsinger-Reif n, C. Bettini, S. Moroff & M. Breen n

author keywords: Boxer; dog; epidemiology; genetics; MCT; Pug
MeSH headings : Age Factors; Animals; Dog Diseases / etiology; Dog Diseases / pathology; Dogs; Female; Male; Mastocytosis, Cutaneous / etiology; Mastocytosis, Cutaneous / pathology; Mastocytosis, Cutaneous / veterinary; Retrospective Studies; Risk Factors; Sex Factors; Skin Neoplasms / etiology; Skin Neoplasms / pathology; Skin Neoplasms / veterinary; Species Specificity
TL;DR: The data indicate that the proportion of high-grade tumours increases with advancing age, and that male and intact dogs have increased odds of developing high- grade tumours, and a genetic association for the development ofhigh-grade MCTs is suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies

LEUKEMIA & LYMPHOMA, 58(7), 1702–1710.

By: D. Seelig*, D. Ito*, C. Forster*, U. Yoon*, M. Breen n, L. Burns*, V. Bachanova*, K. Lindblad-Toh* ...

author keywords: Diffuse large B-cell lymphoma; alternative NF-kappa B pathway; canine model; targeting therapy; comparative pathology
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Cell Line, Tumor; Cell Survival / drug effects; Disease Models, Animal; Dogs; Gene Expression; Genes, Reporter; Humans; Lymphoma, Large B-Cell, Diffuse / drug therapy; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Molecular Targeted Therapy; NF-kappa B / metabolism; Signal Transduction / drug effects
TL;DR: It is demonstrated that dogs with spontaneous DLBCL can provide a useful large animal model to study therapies targeting the ANFκBP and that a small interfering RNA inhibits the activation of the NFκB pathway and induces apoptosis in canineDLBCL cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Evaluation of gene expression and DNA copy number profiles of adipose tissue-derived stromal cells and consecutive neurosphere-like cells generated from dogs with naturally occurring spinal cord injury

American Journal of Veterinary Research, 78(3), 371–380.

By: J. Lim*, S. Koh*, R. Thomas*, M. Breen* & N. Olby*

MeSH headings : Adipose Tissue / cytology; Animals; Cells, Cultured; Comparative Genomic Hybridization; Dogs; Female; Gene Dosage / genetics; Gene Expression Profiling; Gene Expression Regulation; Male; Neural Stem Cells / cytology; Neural Stem Cells / pathology; Neurons / cytology; Neurons / pathology; Proteins / genetics; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / veterinary; Stromal Cells / cytology; Stromal Cells / physiology
TL;DR: ADSCs can potentially be a safe and clinically relevant autologous source for canine neural progenitor cells and DNA copy number stability was suggested by the methods used. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Generation of LIF-independent induced pluripotent stem cells from canine fetal fibroblasts

Theriogenology, 92, 75–82.

By: N. Gonçalves, F. Bressan*, K. Roballo, F. Meirelles*, P. Xavier, H. Fukumasu, C. Williams n, M. Breen n ...

author keywords: iPSC; Canine; Stem cells; Pluripotency; Cellular reprogramming
MeSH headings : Animals; Dogs; Fetus / cytology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / physiology; Gene Expression Regulation / physiology; Leukemia Inhibitory Factor / pharmacology; Mice; Mice, Inbred BALB C; Mice, Nude; Pluripotent Stem Cells / physiology; Polymerase Chain Reaction / veterinary
TL;DR: This report is the first to describe the ability to reprogram canine somatic cells via lentiviral vectors without supplementation and with resistance to enzymatic action, thereby demonstrating the pluripotency of these cell lines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Genomic profiling of canine mast cell tumors identifies DNA copy number aberrations associated with KIT mutations and high histological grade

CHROMOSOME RESEARCH, 25(2), 129–143.

By: H. Mochizuki n, R. Thomas n, S. Moroff & M. Breen n

author keywords: Cancer; Comparative genomic hybridization; Digital PCR; Dog; Mastocytosis; Pug
MeSH headings : Animals; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dogs; Genome / genetics; Mastocytosis, Cutaneous / diagnosis; Mastocytosis, Cutaneous / genetics; Mastocytosis, Cutaneous / pathology; Mutation; Predictive Value of Tests; Proto-Oncogene Proteins c-kit / genetics; Sensitivity and Specificity
TL;DR: Characterization of genomic alterations in canine MCTs may identify genomic regions and/or genes responsible for their development and progression, facilitating the discovery of new therapeutic targets and improved clinical management of this heterogeneous cancer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Integrated immunohistochemical and DNA copy number profiling analysis provides insight into the molecular pathogenesis of canine follicular lymphoma

VETERINARY AND COMPARATIVE ONCOLOGY, 15(3), 852–867.

By: R. Thomas n, Z. Demeter*, K. Kennedy n, L. Borst n, K. Singh*, V. Valli, K. Le Boedec*, M. Breen n

author keywords: BCL2; canine; comparative genomic hybridization; fluorescence in situ hybridization; follicular lymphoma; immunohistochemistry
MeSH headings : Animals; DNA Copy Number Variations / genetics; DNA Fingerprinting / veterinary; Dog Diseases / etiology; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Genome-Wide Association Study / veterinary; Lymphoma, Follicular / etiology; Lymphoma, Follicular / genetics; Lymphoma, Follicular / pathology; Lymphoma, Follicular / veterinary; Male; Risk Factors
TL;DR: Parallel exploration of canine and human cases may reveal alternative tumour-initiating mechanisms other than BCL2 disruption, yielding a more complete definition of the molecular pathogenesis of FL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma

VETERINARY AND COMPARATIVE ONCOLOGY, 15(2), 315–327.

By: K. Im*, A. Graef*, M. Breen n, K. Lindblad-Toh*, J. Modiano* & J. Kim*

author keywords: canine hemangiosarcoma; CXCR4; CXCL12; invasion; migration
MeSH headings : Animals; Cell Line, Tumor; Cell Movement / physiology; Chemokine CXCL12 / physiology; Dog Diseases / pathology; Dogs; Flow Cytometry / veterinary; Gene Expression Profiling / veterinary; Gene Expression Regulation, Neoplastic / physiology; Hemangiosarcoma / pathology; Hemangiosarcoma / veterinary; Neoplasm Invasiveness / pathology; Receptors, CXCR4 / physiology
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy

Journal of Cellular and Molecular Medicine, 21(8), 1503–1512.

By: M. Hensley n, J. Tang n, K. Woodruff n, T. Defrancesco n, S. Tou n, C. Williams n, M. Breen n, K. Meurs n ...

author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy; allogeneic
MeSH headings : Animals; Biomarkers / metabolism; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / immunology; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / therapy; Coronary Vessels / cytology; Coronary Vessels / immunology; Dogs; Echocardiography; Endoglin / genetics; Endoglin / immunology; Female; Gene Expression; Humans; Male; Myocardium / immunology; Myocardium / pathology; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / immunology; Spheroids, Cellular / cytology; Spheroids, Cellular / immunology; Spheroids, Cellular / transplantation; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / immunology; Thy-1 Antigens / genetics; Thy-1 Antigens / immunology; Transplantation, Homologous
TL;DR: The safety and efficacy of allogeneic CDC in a large animal (canine) model of spontaneous DCM and Histology on dog hearts revealed no sign of immune rejection from the transplanted cells. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Malignant canine mammary tumours: Preliminary genomic insights using oligonucleotide array comparative genomic hybridisation analysis

VETERINARY JOURNAL, 222, 68–71.

author keywords: Array comparative genomic hybridisation; Canine mammary tumours; Chromosome; Genetics
MeSH headings : Animals; Comparative Genomic Hybridization / veterinary; DNA Copy Number Variations; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Mammary Neoplasms, Animal / genetics; Mammary Neoplasms, Animal / pathology
TL;DR: High resolution oligonucleotide array comparative genomic hybridisation was performed to assess genome wide DNA copy number changes in 10 malignant canine mammary tumours from seven female dogs, including multiple tumours collected at one time from each of three female dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Sequence analysis of RAS and RAF mutation hot spots in canine carcinoma

VETERINARY AND COMPARATIVE ONCOLOGY, 15(4), 1598–1605.

By: H. Mochizuki n & M. Breen n

author keywords: bladder; cancer; dog; prostate; squamous cell carcinoma; transitional cell carcinoma
MeSH headings : Animals; Dog Diseases / genetics; Dogs; Genes, ras / genetics; Mutation / genetics; Neoplasms / genetics; Neoplasms / veterinary; Proto-Oncogene Proteins B-raf / genetics; Sequence Analysis, DNA / veterinary
TL;DR: Evaluated the mutational status of three RAS genes (HRAS, KRAS and NRAS) in four types of canine carcinoma with and without the BRAF V595E mutation, indicating similar functional consequence of these mutations (e.g. MAPK pathway activation). (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Comprehensive genomic characterization of five canine lymphoid tumor cell lines

BMC Veterinary Research, 12.

By: S. Roode, D. Rotroff, K. Richards, P. Moore, A. Motsinger-Reif, Y. Okamura, T. Mizuno, H. Tsujimoto, S. Suter, M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Detection of Copy Number Imbalance in Canine Urothelial Carcinoma With Droplet Digital Polymerase Chain Reaction

VETERINARY PATHOLOGY, 53(4), 764–772.

By: H. Mochizuki n, S. Shapiro n, M. Breen n & V. pathology

author keywords: comparative genomic hybridization; cytogenetics; dogs; molecular diagnostic; transitional cell carcinoma; polymerase chain reaction; urinary bladder; urothelial carcinoma
MeSH headings : Animals; Carcinoma, Transitional Cell / diagnosis; Carcinoma, Transitional Cell / genetics; Carcinoma, Transitional Cell / pathology; Carcinoma, Transitional Cell / veterinary; Comparative Genomic Hybridization / veterinary; DNA Copy Number Variations; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Polymerase Chain Reaction / veterinary; Urinary Bladder / pathology; Urinary Bladder Neoplasms / diagnosis; Urinary Bladder Neoplasms / genetics; Urinary Bladder Neoplasms / pathology; Urinary Bladder Neoplasms / veterinary; Urologic Neoplasms / diagnosis; Urologic Neoplasms / genetics; Urologic Neoplasms / pathology; Urologic Neoplasms / veterinary
TL;DR: The findings show that ddPCR is a useful molecular technique to detect CNAs and may be used as a noninvasive molecular diagnostic test for canine UC. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

A novel canine kidney cell line model for the evaluation of neoplastic development: karyotype evolution associated with spontaneous immortalization and tumorigenicity

CHROMOSOME RESEARCH, 23(4), 663–680.

By: R. Omeir*, R. Thomas n, B. Teferedegne*, C. Williams n, G. Foseh*, J. Macauley*, L. Brinster*, J. Beren* ...

author keywords: Neoplastic transformation; Tumorigenicity; Canine chromosomes; Comparative genomic hybridization (CGH); Fluorescence in situ hybridization (FISH); Madin-Darby canine kidney (MDCK) cell line; CKB1-3T7 cell line
MeSH headings : Animals; Cell Line; Cell Line, Transformed; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic / genetics; Cells, Cultured; Chromosome Aberrations; DNA Copy Number Variations; Dogs; In Situ Hybridization, Fluorescence; Karyotype; Madin Darby Canine Kidney Cells; Male; Neoplasms / genetics; Neoplasms / pathology
TL;DR: Through integrated cytogenomic and phenotypic characterization of serial passages of CKB1-3T7 from initiation to development of a tumorigenic phenotype, this work presents a robust and readily accessible model of spontaneous neoplastic transformation that overcomes many of the limitations of earlier studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

BRAF Mutations in Canine Cancers

PLOS ONE, 10(6).

By: H. Mochizuki n, K. Kennedy n, S. Shapiro n & M. Breen n

Contributors: H. Mochizuki n, K. Kennedy n, S. Shapiro n & M. Breen n

MeSH headings : Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Dogs; Exons / genetics; Female; Genetic Predisposition to Disease; Humans; Male; Molecular Sequence Data; Mutation / genetics; Neoplasms / genetics; Neoplasms / veterinary; Proto-Oncogene Proteins B-raf / chemistry; Proto-Oncogene Proteins B-raf / genetics; Sequence Analysis, DNA
TL;DR: The evolutional conservation of the BRAF V600E mutation highlights the importance of MAPK pathway activation in neoplasia and may offer opportunity for molecular diagnostics and targeted therapeutics for dogs bearing BRAF-mutated cancers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Canine urothelial carcinoma: genomically aberrant and comparatively relevant

Chromosome Research, 23(2), 311–331.

By: S. Shapiro n, S. Raghunath n, C. Williams n, A. Motsinger-Reif n, J. Cullen n, T. Liu*, D. Albertson*, M. Ruvolo* ...

author keywords: Canine; Urothelial carcinoma; Transitional cell carcinoma; Cytogenetics; Chromosome aberration; Array comparative genomic hybridization; Comparative oncology
MeSH headings : Animals; Biopsy; Carcinoma / veterinary; Chromosome Aberrations; Comparative Genomic Hybridization; Computational Biology / methods; DNA Copy Number Variations; Dogs; Female; Genetic Loci; Genomics / methods; Humans; In Situ Hybridization, Fluorescence; Male; Urologic Neoplasms / veterinary
TL;DR: It is proposed that common aberrations found in primary canine UC biopsies are indicative of an evolutionarily conserved mechanism of pathogenesis and harbor genes key to urothelial neoplasia, warranting investigation for diagnostic, prognostic, and therapeutic applications. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Comparative cytogenetic characterization of primary canine melanocytic lesions using array CGH and fluorescence in situ hybridization

CHROMOSOME RESEARCH, 23(2), 171–186.

By: K. Poorman n, L. Borst n, S. Moroff, S. Roy n, P. Labelle, A. Motsinger-Reif n, M. Breen n

author keywords: Canine; Oral melanoma; Cytogenetics; Array; Comparative genomic hybridization
MeSH headings : Animals; Chromosome Aberrations; Cluster Analysis; Comparative Genomic Hybridization; Computational Biology; DNA Copy Number Variations; Dogs; Female; Humans; In Situ Hybridization, Fluorescence; Male; Melanoma / genetics; Melanoma / metabolism; Melanoma / pathology; Mouth Neoplasms / genetics; Mouth Neoplasms / pathology; Penetrance; Skin Neoplasms
TL;DR: This study suggests that in concordance with what is known for human melanomas, canine melanomas of the oral mucosa and cutaneous epithelium are discrete and initiated by different molecular pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 review

Comparative oncology: what dogs and other species can teach us about humans with cancer

By: J. Schiffman* & M. Breen n

author keywords: comparative oncology; genomics; genetics; cancer; canine; human
MeSH headings : Animals; Breeding; Disease Models, Animal; Dog Diseases / etiology; Dogs; Female; Genome-Wide Association Study / veterinary; Genomics; Germ-Line Mutation; Humans; Male; Neoplasms / etiology; Neoplasms / veterinary; Risk Factors; Species Specificity; Translational Research, Biomedical
TL;DR: This review begins with the genetic origins of canines and their advantage in cancer research, and next focuses on recent findings in comparative oncology related to inherited, or genetic, risk for tumour development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Detection of BRAF Mutation in Urine DNA as a Molecular Diagnostic for Canine Urothelial and Prostatic Carcinoma

PLOS ONE, 10(12).

By: H. Mochizuki n, S. Shapiro n & M. Breen n

Contributors: H. Mochizuki n, S. Shapiro n & M. Breen n

MeSH headings : Animals; Biomarkers, Tumor / urine; DNA / urine; Dogs; Male; Mutation; Polymerase Chain Reaction; Prostatic Neoplasms / diagnosis; Prostatic Neoplasms / urine; Proto-Oncogene Proteins B-raf / genetics; Urinary Bladder Neoplasms / diagnosis; Urinary Bladder Neoplasms / urine
TL;DR: It is shown that ddPCR is a sensitive molecular technique with the potential to facilitate accurate and non-invasive means of canine UC and PC diagnosis. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Genome-wide assessment of recurrent genomic imbalances in canine leukemia identifies evolutionarily conserved regions for subtype differentiation

Chromosome Research, 23(4), 681–708.

By: S. Roode n, D. Rotroff n, A. Avery*, S. Suter n, D. Bienzle*, J. Schiffman*, A. Motsinger-Reif n, M. Breen n

author keywords: Leukemia; Canine; Chromosome; Comparative genomic hybridization; Comparative genomics
MeSH headings : Algorithms; Animals; Cell Transformation, Neoplastic / genetics; Chromosome Aberrations; Chromosome Mapping; Cluster Analysis; Comparative Genomic Hybridization; Conserved Sequence; DNA Copy Number Variations; Disease Models, Animal; Dogs; Evolution, Molecular; Female; Gene Dosage; Genome-Wide Association Study; Genomic Library; Genomics; Humans; In Situ Hybridization, Fluorescence; Leukemia / diagnosis; Leukemia / genetics; Leukemia / metabolism; Male
TL;DR: The use of canine leukemia as a relevant in vivo model for human leukemia is supported and the need to further explore the conserved genomic regions of interest for their clinical impact is justified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 article

Peto's paradox and the promise of comparative oncology

Nunney, L., Maley, C. C., Breen, M., Hochberg, M. E., & Schiffman, J. D. (2015, July 19). PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol. 370.

author keywords: Peto's paradox; comparative oncology; evolution; life-history theory; cancer; modelling
MeSH headings : Animals; Biological Evolution; Body Size; Cocarcinogenesis; Female; Humans; Longevity; Male; Mammals; Models, Biological; Neoplasms / etiology
TL;DR: The history of the field is reviewed and how the contributions use empirical, comparative and theoretical approaches to address the processes and patterns associated with ‘Peto's paradox’, the lack of a statistical relationship of cancer incidence with body size and longevity is outlined. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Canine Prostate Cancer Cell Line (Probasco) Produces Osteoblastic Metastases In Vivo

PROSTATE, 74(13), 1251–1265.

By: J. Simmons*, W. Dirksen*, B. Hildreth*, C. Dorr n, C. Williams n, R. Thomas n, M. Breen n, R. Toribio*, T. Rosol*

author keywords: prostate cancer; osteoblastic metastases; canine; dog
MeSH headings : Animals; Biomarkers, Tumor / genetics; Biomarkers, Tumor / metabolism; Bone Neoplasms / genetics; Bone Neoplasms / metabolism; Bone Neoplasms / secondary; Carcinoma / genetics; Carcinoma / metabolism; Carcinoma / secondary; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dogs; Male; Mice; Mice, Nude; Neoplasm Transplantation; Osteoblasts / metabolism; Osteoblasts / pathology; Prostatic Neoplasms / genetics; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology
TL;DR: This study established and characterized a novel canine prostate cancer cell line that will contribute to the understanding of prostate cancer pathogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Definition of the Cattle Killer Cell Ig-like Receptor Gene Family: Comparison with Aurochs and Human Counterparts

JOURNAL OF IMMUNOLOGY, 193(12), 6016–6030.

By: N. Sanderson*, P. Norman*, L. Guethlein*, S. Ellis*, C. Williams n, M. Breen n, S. Park*, D. Magee* ...

MeSH headings : Animals; Cattle; Chromosome Mapping; Chromosomes, Mammalian; Cloning, Molecular; Evolution, Molecular; Gene Library; Genetic Loci; Genome; Haplotypes; Humans; Immunoglobulins / genetics; Molecular Sequence Data; Multigene Family; Phenotype; Phylogeny; Receptors, IgG / metabolism; Receptors, KIR / classification; Receptors, KIR / genetics; Receptors, KIR / metabolism; Receptors, Natural Killer Cell / metabolism; Sequence Analysis, DNA; Signal Transduction; Telomere
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

CHROMOSOME RESEARCH, 22(3), 305–319.

author keywords: canine; chromosome; hemangiosarcoma; comparative genomic hybridization (CGH)
MeSH headings : Animals; Breeding; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dog Diseases / genetics; Dogs; Gene Amplification; Gene Expression Profiling; Genetic Heterogeneity; Genome; Hemangiosarcoma / genetics; Hemangiosarcoma / veterinary; Penetrance; Vascular Endothelial Growth Factor A / genetics
TL;DR: Analysis of genome-wide microarray-based somatic DNA copy number profiling of 75 primary intra-abdominal hemangiosarcomas from five popular dog breeds supports prior transcriptional studies suggesting that the clinical heterogeneity of this cancer may reflect the existence of multiple, molecularly distinct subtypes of canine hemangiusarcoma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Identification of Three Molecular and Functional Subtypes in Canine Hemangiosarcoma through Gene Expression Profiling and Progenitor Cell Characterization

AMERICAN JOURNAL OF PATHOLOGY, 184(4), 985–995.

By: B. Gorden*, J. Kim*, A. Sarver*, A. Frantz*, M. Breen n, K. Lindblad-Toh*, . Timothy D. O'Brien, L. Sharkey*, J. Modiano*, E. Dickerson*

MeSH headings : Animals; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Gene Expression Profiling; Hemangiosarcoma / genetics; Hemangiosarcoma / pathology; Hemangiosarcoma / veterinary; Immunophenotyping; Neoplastic Stem Cells / pathology; Oligonucleotide Array Sequence Analysis
TL;DR: Improved understanding of the mechanisms that determine the molecular and phenotypic differentiation of tumor cells in vivo could change paradigms regarding the origin and progression of endothelial sarcomas. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Gene selection and cancer type classification of diffuse large-B-cell lymphoma using a bivariate mixture model for two-species data

Human Genomics, 7.

By: Y. Su, D. Nielsen, L. Zhu, K. Richards, S. Suter, M. Breen, A. Motsinger-Reif, J. Osborne

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Growth Requirements and Chromosomal Instability of Induced Pluripotent Stem Cells Generated from Adult Canine Fibroblasts

Stem Cells and Development, 22(6), 951–963.

By: S. Koh n, R. Thomas n, S. Tsai n, S. Bischoff n, J. Lim n, M. Breen n, N. Olby n, J. Piedrahita n

MeSH headings : Alkaline Phosphatase / metabolism; Animals; Antigens, Differentiation / genetics; Antigens, Differentiation / metabolism; Cell Differentiation; Cell Shape; Cells, Cultured; Chromosomal Instability; Coculture Techniques; Comparative Genomic Hybridization; Dogs; Fibroblasts / physiology; Gene Expression; In Situ Hybridization, Fluorescence; Induced Pluripotent Stem Cells / enzymology; Induced Pluripotent Stem Cells / pathology; Induced Pluripotent Stem Cells / transplantation; Kruppel-Like Factor 4; Mice; Mice, SCID; Recombinant Proteins / biosynthesis; Recombinant Proteins / genetics; Teratoma / genetics; Teratoma / pathology; Transcription Factors / biosynthesis; Transcription Factors / genetics
TL;DR: The isolated ciPSCs have similar characteristics to ESCs from other species, but the exact cellular mechanisms behind their unique co-dependency on both FGF2 and LIF are still unknown. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2013 journal article

Molecular characterization of canine BCR-ABL-positive chronic myelomonocytic leukemia before and after chemotherapy

Veterinary Clinical Pathology, 42(3), 314–322.

By: S. Culver n, D. Ito*, L. Borst n, J. Bell, J. Modiano* & M. Breen n

author keywords: Chromosome; cytogenetics; hematopoietic cells; remission; vincristine
MeSH headings : Animals; Chromosomes, Human, Pair 7 / genetics; Comparative Genomic Hybridization / veterinary; Dog Diseases / drug therapy; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Fusion Proteins, bcr-abl / genetics; Humans; In Situ Hybridization, Fluorescence / veterinary; Leukemia, Myelomonocytic, Chronic / drug therapy; Leukemia, Myelomonocytic, Chronic / genetics; Leukemia, Myelomonocytic, Chronic / pathology; Leukemia, Myelomonocytic, Chronic / veterinary; Male; Trisomy / genetics
TL;DR: Cytology and flow cytometric techniques were used to diagnose chronic myelomonocytic leukemia in a dog and the applicability of cytogenetics techniques to evaluate the cytogenetic response of canine leukemia to chemotherapy was demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2013 article

Naturally occuring canine cancers: powerful models for stimulating pharmacogenomic advancement in human medicine

Rotroff, D. M., Thomas, R., Breen, M., & Motsinger-Reif, A. A. (2013, December). PHARMACOGENOMICS, Vol. 14, pp. 1929–1931.

By: D. Rotroff n, R. Thomas n, M. Breen n & A. Motsinger-Reif n

author keywords: cancer; canine model; chemotherapy; clinical trials
MeSH headings : Animals; Disease Models, Animal; Dogs; Humans; Neoplasms / drug therapy; Neoplasms / pathology; Pharmacogenetics / methods
TL;DR: Dogs exhibit a wide variety of spontaneous cancers that share extensive clinicopathologic features with those of human patients, offering a unique opportunity for comparative analysis of cancer etiology and pharmacogenomics. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Partial cytogenetic response with toceranib and prednisone treatment in a young dog with chronic monocytic leukemia

ANTI-CANCER DRUGS, 24(10), 1098–1103.

By: M. Perez, S. Culver*, J. Owen*, M. Dunbar*, K. Kow, M. Breen n, R. Milner*

author keywords: cytogenetic analysis; fluorescence in-situ hybridization; monocytosis; toceranib; tyrosine kinase inhibitor
MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cell Proliferation / drug effects; Dog Diseases / drug therapy; Dog Diseases / genetics; Dogs; Female; Fusion Proteins, bcr-abl / antagonists & inhibitors; Fusion Proteins, bcr-abl / genetics; In Situ Hybridization, Fluorescence; Indoles / administration & dosage; Indoles / therapeutic use; Leukemia, Myeloid / drug therapy; Leukemia, Myeloid / genetics; Leukemia, Myeloid / pathology; Leukemia, Myeloid / veterinary; Prednisone / administration & dosage; Prednisone / therapeutic use; Pyrroles / administration & dosage; Pyrroles / therapeutic use; Translocation, Genetic; Treatment Outcome
TL;DR: A case of CMoL in a young dog that achieved clinical remission with treatment with the tyrosine kinase inhibitor toceranib and prednisone is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations

Cancer Genetics, 205(11), 572–587.

By: A. Angstadt n, V. Thayanithy*, S. Subramanian*, J. Modiano* & M. Breen n

author keywords: Osteosarcoma; oligo-aCGH; canine; comparative oncology
MeSH headings : Adolescent; Adult; Algorithms; Animals; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Child; Chromosome Aberrations; Comparative Genomic Hybridization / methods; DNA Copy Number Variations; Dog Diseases / genetics; Dogs; Female; Genome, Human; Genomics / methods; Humans; Male; Osteosarcoma / genetics; Osteosarcoma / veterinary; Species Specificity
TL;DR: These findings support and build upon the high level of cytogenetic complexity, through the identification of shared regions of microaberration and functional analysis of possible orthologous OS-associated genes to pinpoint the cellular processes most commonly affected by aberration in human and canine OS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: August 14, 2021

2012 journal article

Acute myeloblastic leukemia with associated BCR-ABL translocation in a dog

VETERINARY CLINICAL PATHOLOGY, 41(3), 362–368.

By: J. Figueiredo*, S. Culver n, E. Behling-Kelly*, M. Breen n & K. Friedrichs*

author keywords: Cytogenetics; FISH; immunophenotyping; Raleigh chromosome
MeSH headings : Animals; Bone Marrow / pathology; Cytogenetic Analysis / veterinary; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Fusion Proteins, bcr-abl / genetics; Hematologic Tests / veterinary; Immunophenotyping / veterinary; In Situ Hybridization, Fluorescence / veterinary; Leukemia, Myeloid, Acute / genetics; Leukemia, Myeloid, Acute / immunology; Leukemia, Myeloid, Acute / pathology; Leukemia, Myeloid, Acute / veterinary; Male; Translocation, Genetic / genetics
TL;DR: This is the first report of AML with a BCR-ABL translocation in a domestic animal and large multinucleated cells were observed frequently, supporting megakaryocytic lineage. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas

Cancer, 118(23), 5878–5887.

author keywords: angiosarcoma; p53; phosphoinositide-3-kinase; catalytic; alpha polypeptide; phosphatase and tensin homolog; complex karyotype
MeSH headings : Adult; Aged; Aged, 80 and over; Class I Phosphatidylinositol 3-Kinases; Female; Genes, p53; Genomics; Hemangiosarcoma / etiology; Hemangiosarcoma / genetics; Humans; Male; Middle Aged; Mutation; PTEN Phosphohydrolase / genetics; Phosphatidylinositol 3-Kinases / physiology; Proto-Oncogene Proteins B-raf / genetics; Proto-Oncogene Proteins c-akt / physiology; Proto-Oncogene Proteins c-mdm2 / analysis; Signal Transduction / physiology; TOR Serine-Threonine Kinases / physiology
TL;DR: The p53 and phosphoinositide‐3‐kinase, catalytic, alpha polypeptide/v‐akt murine thymoma viral oncogene homolog/mechanistic target of rapamycin (PIK3CA/AKT/mTOR) pathways frequently are altered in sarcoma with complex genomics, such as leiomyosarcoma (LMS) or undifferentiated pleomorphic sarcomA (UPS). (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: June 6, 2020

2012 journal article

Array-based comparative genomic hybridization-guided identification of reference genes for normalization of real-time quantitative polymerase chain reaction assay data for lymphomas, histiocytic sarcomas, and osteosarcomas of dogs

AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(9), 1335–1343.

By: P. Tsai n & M. Breen*

MeSH headings : Animals; Comparative Genomic Hybridization / methods; Comparative Genomic Hybridization / standards; Comparative Genomic Hybridization / veterinary; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Gene Dosage; Histiocytic Sarcoma / genetics; Histiocytic Sarcoma / pathology; Histiocytic Sarcoma / veterinary; Immunohistochemistry; Lymphoma / genetics; Lymphoma / pathology; Lymphoma / veterinary; Osteosarcoma / genetics; Osteosarcoma / pathology; Osteosarcoma / veterinary; RNA, Neoplasm / chemistry; RNA, Neoplasm / genetics; Real-Time Polymerase Chain Reaction / methods; Real-Time Polymerase Chain Reaction / standards; Real-Time Polymerase Chain Reaction / veterinary; Reference Standards
TL;DR: Results of the present study indicated LOC611555 may be a useful RT-qPCR assay reference gene for multiple tissue types, such as lymphomas, osteosarcomas, or histiocytic sarcomas. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies

LEUKEMIA & LYMPHOMA, 53(7), 1390–1398.

By: D. Ito, A. Frantz, C. Williams*, R. Thomas n, R. Burnett*, A. Avery*, M. Breen n, N. Mason*, . Timothy D. O'Brien, J. Modiano*

author keywords: Diffuse large B-cell lymphoma; CD40L; primary cell culture; canine model; cytotoxicity assay
MeSH headings : Animals; CD40 Ligand / genetics; CD40 Ligand / metabolism; CD40 Ligand / pharmacology; Cell Culture Techniques / methods; Cell Proliferation / drug effects; Cell Survival / drug effects; Coculture Techniques; Dogs; Dose-Response Relationship, Drug; Feeder Cells / metabolism; Gene Expression Profiling; Humans; Lymphoma, Large B-Cell, Diffuse / genetics; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Oligonucleotide Array Sequence Analysis; Recombinant Proteins / pharmacology; Tumor Cells, Cultured
TL;DR: This work used primary canine diffuse large B-cell lymphoma to establish a culture system that reliably supports the growth of these cells in vitro and illustrates the utility of the feeder cell-free culture system for comparable assessment of cytotoxicity using dog and human B- cell malignancies. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 conference paper

Generation and characterization of induced pluripotent stem cells (iPS) from adult canine fibroblasts

Reproduction in Domestic Animals, 47, 418–419.

By: S. Koh, S. Tsai, S. Bischoff, R. Thomas, J. Lim, M. Breen, N. Olby, J. Piedrahita

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma

BONE, 50(1), 171–181.

By: V. Thayanithy*, A. Sarver*, R. Kartha*, L. Li*, A. Angstadt n, M. Breen n, C. Steer*, J. Modiano*, S. Subramanian*

author keywords: Bone neoplasm; cMYC; Osteosarcoma; miR-17-92; 14q32 miRNAs
MeSH headings : Adolescent; Bone Neoplasms / genetics; Bone Neoplasms / pathology; Bone and Bones / anatomy & histology; Bone and Bones / pathology; Bone and Bones / physiology; Cell Line, Tumor; Child; Chromosomes, Human, Pair 14 / genetics; DNA Copy Number Variations; Gene Expression Profiling; Gene Regulatory Networks; Humans; MicroRNAs / genetics; Microarray Analysis; Multigene Family; Osteosarcoma / genetics; Osteosarcoma / pathology; Proto-Oncogene Proteins c-myc / genetics
TL;DR: It is shown that microRNAs (miRNAs) at the chr.14q32 locus are significantly downregulated in osteosarcoma compared to normal bone tissues, supporting a model where the deregulation of a network involving 14q32 miRNAs, cMYC and miR-17-92 mi RNAs could contribute to osteosARcoma pathogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification

GENES CHROMOSOMES & CANCER, 51(6), 569–578.

By: A. Italiano*, R. Thomas n, M. Breen n, L. Zhang*, A. Crago*, S. Singer*, R. Khanin*, R. Maki* ...

MeSH headings : Adult; Aged; Aged, 80 and over; Comparative Genomic Hybridization; DNA-Binding Proteins / biosynthesis; DNA-Binding Proteins / genetics; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, myc; Hemangiosarcoma / chemistry; Hemangiosarcoma / genetics; Hemangiosarcoma / metabolism; Humans; In Situ Hybridization, Fluorescence; Male; MicroRNAs / biosynthesis; MicroRNAs / genetics; Middle Aged; Proto-Oncogene Proteins c-myc / biosynthesis; Proto-Oncogene Proteins c-myc / genetics; RNA, Long Noncoding; Sequence Analysis, RNA; Thrombospondin 1 / biosynthesis; Thrombospondin 1 / genetics; Transcription Factors / biosynthesis; Transcription Factors / genetics; Vascular Neoplasms / chemistry; Vascular Neoplasms / genetics; Vascular Neoplasms / metabolism
TL;DR: MyC amplification may play a crucial role in the angiogenic phenotype of AS through upregulation of the miR‐17‐92 cluster, which subsequently downregulates THBS1, a potent endogenous inhibitor of angiogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes

CHROMOSOME RESEARCH, 19(6), 685–708.

By: S. Becker n, R. Thomas n, V. Trifonov*, R. Wayne*, A. Graphodatsky* & M. Breen n

author keywords: B chromosomes; fragile breakage model; breakpoint reuse theory; fluorescence in situ hybridization; phylogenetic; Canidae
MeSH headings : Animals; Biological Evolution; Canidae / genetics; Chromosome Mapping; Chromosome Painting; Chromosomes, Artificial, Bacterial; Chromosomes, Mammalian / genetics; Cytogenetics; Dogs / genetics; Foxes / genetics; Genome; In Situ Hybridization, Fluorescence; Raccoon Dogs / genetics
TL;DR: This work suggests that the complex karyotype rearrangements associated with speciation of the Canidae reflect unstable chromosome regions described by the fragile breakage model and provides evidence that these breakpoints are also recurrently associated with spontaneous canine cancers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

BCR-ABL translocation in a dog with chronic monocytic leukemia

VETERINARY CLINICAL PATHOLOGY, 40(1), 40–47.

By: J. Cardona, R. Milner*, A. Alleman, C. Williams n, W. Vernau*, M. Breen n, M. Tompkins n

author keywords: FISH; flow cytometry; monocytosis; myeloproliferative disorder
MeSH headings : Animals; Bone Marrow Cells / pathology; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Flow Cytometry / veterinary; Leukemia, Myeloid / diagnosis; Leukemia, Myeloid / genetics; Leukemia, Myeloid / pathology; Leukemia, Myeloid / veterinary; Translocation, Genetic / genetics
TL;DR: Clinical and laboratory findings and the protracted course supported a diagnosis of chronic monocytic leukemia (CMoL), the first case of CMoL with a BCR-ABL chromosomal abnormalitiy described in dogs, and may have clinical implications for treatment of dogs with chronic leukemias associated with particular genetic mutations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Characterization of Canine Osteosarcoma by Array Comparative Genomic Hybridization and RT-qPCR: Signatures of Genomic Imbalance in Canine Osteosarcoma Parallel the Human Counterpart

GENES CHROMOSOMES & CANCER, 50(11), 859–874.

MeSH headings : Animals; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Comparative Genomic Hybridization; Core Binding Factor Alpha 1 Subunit / genetics; DNA Copy Number Variations; Dog Diseases / genetics; Dogs; Female; Gene Dosage; Genomic Instability; Humans; In Situ Hybridization, Fluorescence; Male; Membrane Proteins / genetics; Osteosarcoma / genetics; Osteosarcoma / veterinary; PTEN Phosphohydrolase / genetics; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Tumor Suppressor Proteins / genetics
TL;DR: Large scale screening of genomic imbalance in canine OS further validates the use of the dog as a suitable model for human cancers, supporting the idea that dysregulation discovered in canine cancers will provide an avenue for complementary study in human counterparts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Development of a Brain Metastatic Canine Prostate Cancer Cell Line

PROSTATE, 71(12), 1251–1263.

By: N. Thudi*, S. Shu*, C. Martin*, L. Lanigan*, M. Nadella*, A. Van Bokhoven*, J. Werbeck*, J. Simmons* ...

author keywords: prostate cancer; brain metastasis; spinal cord metastasis; dog; canine; bone metastasis
MeSH headings : Adrenal Gland Neoplasms / epidemiology; Adrenal Gland Neoplasms / secondary; Animals; Antineoplastic Agents / pharmacology; Bone Neoplasms / epidemiology; Bone Neoplasms / secondary; Boronic Acids / pharmacology; Bortezomib; Brain Neoplasms / epidemiology; Brain Neoplasms / metabolism; Brain Neoplasms / pathology; Brain Neoplasms / secondary; Carcinogenicity Tests; Carcinoma / epidemiology; Carcinoma / metabolism; Carcinoma / pathology; Carcinoma / secondary; Cell Division; Cell Line, Tumor / drug effects; Cell Line, Tumor / pathology; Dogs; Immunohistochemistry; Incidence; Injections, Subcutaneous; Keratin-18 / metabolism; Keratin-7 / metabolism; Keratin-8 / metabolism; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Connective Tissue / secondary; Parathyroid Hormone-Related Protein / metabolism; Phenylbutyrates / antagonists & inhibitors; Prostatic Neoplasms / pathology; Pyrazines / pharmacology; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord Neoplasms / epidemiology; Spinal Cord Neoplasms / secondary; Subcutaneous Tissue; Transplantation, Heterologous
TL;DR: The goal of the study was to establish and characterize a new prostate cancer line derived from a dog with spontaneous prostate cancer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

FLT3 mutations in canine acute lymphocytic leukemia

BMC CANCER, 11.

By: S. Suter n, G. Small, E. Seiser n, R. Thomas n, M. Breen n & K. Richards

MeSH headings : Amino Acid Sequence; Animals; Blotting, Western; Carbazoles / pharmacology; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; DNA Mutational Analysis; DNA, Neoplasm / chemistry; DNA, Neoplasm / genetics; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases / metabolism; Furans; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Mutation; Phosphorylation / drug effects; Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism; Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology; Reverse Transcriptase Polymerase Chain Reaction; STAT5 Transcription Factor / metabolism; fms-Like Tyrosine Kinase 3 / antagonists & inhibitors; fms-Like Tyrosine Kinase 3 / genetics; fms-Like Tyrosine Kinase 3 / metabolism
TL;DR: Results show that ALL andFLT3 biology is conserved between canine and human patients, supporting the notion that canine ALL, in conjunction with the GL-1 cell line, will be useful in the development of a relevant large animal model to aid in the study of human FLT3 mutant leukemias. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach

BONE, 49(3), 356–367.

By: M. Scott*, A. Sarver*, K. Gavin*, V. Thayanithy*, D. Getzy*, R. Newman*, G. Cutter*, K. Lindblad-Toh* ...

author keywords: Osteosarcoma; Gene expression profiling; Cell cycle; DNA damage checkpoint; Tumor microenvironment; Canine
MeSH headings : Animals; Bone Neoplasms / classification; Bone Neoplasms / genetics; Bone Neoplasms / pathology; Cluster Analysis; Cohort Studies; Cyclin B2 / genetics; Cyclin B2 / metabolism; Dogs; Female; Gene Expression Profiling; Humans; Kaplan-Meier Estimate; Male; Oligonucleotide Array Sequence Analysis / methods; Osteosarcoma / classification; Osteosarcoma / genetics; Osteosarcoma / pathology; Prognosis; Vimentin / genetics; Vimentin / metabolism
TL;DR: The results indicate that the narrower genetic diversity of dogs can be utilized to group complex human osteosarcoma into biologically and clinically relevant molecular subtypes, which in turn may enhance prognosis and prediction, and identify relevant therapeutic targets. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Reading between the lines: molecular characterization of five widely used canine lymphoid tumour cell lines

Veterinary and Comparative Oncology, 11(1), 30–50.

By: E. Seiser n, R. Thomas n, K. Richards n, M. Kathryn Kelley n, P. Moore*, S. Suter n, M. Breen n

author keywords: canine; cell line; comparative; lymphoid neoplasia; microarray; model
MeSH headings : Animals; Cell Line, Tumor; DNA / genetics; DNA / metabolism; Dog Diseases / metabolism; Dogs; Flow Cytometry; Gene Expression Regulation, Neoplastic / physiology; Karyotype; Lymphoma / metabolism; Neoplasm Proteins / genetics; Neoplasm Proteins / metabolism; RNA / genetics; RNA / metabolism; Real-Time Polymerase Chain Reaction / veterinary; Transcriptome
TL;DR: Gene expression profiling and RT-PCR analyses defined the relationship between genomic imbalance and transcriptional dysregulation in each cell line, clarifying their relevance as models of discrete functional pathways with biological and therapeutic significance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2011 journal article

Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

Leukemia & Lymphoma, 52(7), 1321–1335.

By: R. Thomas*, E. Seiser*, A. Motsinger-Reif*, L. Borst*, V. Valli, K. Kelley, S. Suter*, D. Argyle ...

author keywords: Comparative genomic hybridization (CGH); canine; lymphoma; chromosome; microarray
MeSH headings : Aneuploidy; Animals; Breeding; Comparative Genomic Hybridization; Cyclin-Dependent Kinase Inhibitor p16 / genetics; DNA Copy Number Variations / genetics; Dogs; Gene Expression Regulation, Neoplastic; Genomics; Immunophenotyping; Lymphoma, Non-Hodgkin / genetics; Lymphoma, Non-Hodgkin / pathology
TL;DR: It is hypothesized that the restricted genetic variation of purebred dogs, combined with the contrasting architecture of the human and canine karyotypes, will increase the penetrance of fundamental NHL-associated chromosomal aberrations in both species. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2011 journal article

The genome of the green anole lizard and a comparative analysis with birds and mammals

Nature, 477(7366), 587–591.

By: J. Alföldi*, F. Di Palma*, M. Grabherr*, C. Williams n, L. Kong*, E. Mauceli*, P. Russell*, C. Lowe* ...

MeSH headings : Animals; Birds / genetics; Chickens / genetics; Evolution, Molecular; GC Rich Sequence / genetics; Genome / genetics; Genomics; Humans; Lizards / genetics; Mammals / genetics; Molecular Sequence Data; Phylogeny; Synteny / genetics; X Chromosome / genetics
TL;DR: Comparative gene analysis shows that amniote egg proteins have evolved significantly more rapidly than other proteins, and an anole phylogeny resolves basal branches to illuminate the history of their repeated adaptive radiations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Crossref
Added: August 14, 2021

2010 journal article

Mature Hair Follicles Generated from Dissociated Cells: A Universal Mechanism of Folliculoneogenesis

DEVELOPMENTAL DYNAMICS, 239(10), 2619–2626.

By: Y. Zheng, A. Nace, W. Chen, K. Watkins, L. Sergott, Y. Homan, J. Vandeberg*, M. Breen n, K. Stenn

author keywords: hair follicle; morphogenesis; organogenesis
MeSH headings : Animals; Cell Cycle / genetics; Cell Cycle / physiology; Dogs; Hair Follicle / cytology; Hair Follicle / embryology; Humans; Opossums; Organogenesis / genetics; Organogenesis / physiology; Rats; Skin / cytology; Skin / metabolism
TL;DR: There is essentially one way by which dissociated mammalian skin cells form a new hair follicle in vivo and that this mechanism has been highly conserved, according to Developmental Dynamics 239:2619–2626. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Predicting Residential Air Exchange Rates from Questionnaires and Meteorology: Model Evaluation in Central North Carolina

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 44(24), 9349–9356.

By: M. Breen n, M. Breen n, R. Williams n & B. Schultz n

MeSH headings : Air Movements; Air Pollutants / analysis; Air Pollution, Indoor / analysis; Air Pollution, Indoor / statistics & numerical data; Atmosphere / chemistry; Environmental Monitoring / methods; Forecasting; Meteorological Concepts; Models, Chemical; North Carolina; Particle Size; Seasons; Surveys and Questionnaires
TL;DR: The capability of the LBL, LBLX, and SF models could help reduce the AER uncertainty in air pollution exposure models used to develop exposure metrics for health studies. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by microarray-based CGH analysis

CHROMOSOME RESEARCH, 17(7), 927–934.

author keywords: comparative genomic hybridization (CGH); canine; transmissible venereal tumor; chromosome; microarray
MeSH headings : Animals; Comparative Genomic Hybridization; DNA Copy Number Variations; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / transmission; Dogs; Female; Gene Expression Regulation, Neoplastic; Genome; Male; Oligonucleotide Array Sequence Analysis; Venereal Tumors, Veterinary / genetics; Venereal Tumors, Veterinary / immunology
TL;DR: Characterization of a strategically selected panel of CTVT cases is presented using microarray-based comparative genomic hybridization analysis, showing for the first time that the tumor presents with an extensive range of non-random chromosome copy number aberrations that are distributed widely throughout the dog genome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Generation and characterization of novel canine malignant mast cell line CL1

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 127(1-2), 114–124.

By: T. Lin*, R. Thomas n, P. Tsai n, M. Breen n & C. London*

author keywords: Mast cell tumor; KIT; Cell line
MeSH headings : Animals; Base Sequence; Cell Degranulation; Cell Line, Tumor; DNA Primers / genetics; DNA, Neoplasm / genetics; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Female; Genome-Wide Association Study; Immunophenotyping; Mast Cells / immunology; Mast Cells / pathology; Mast Cells / physiology; Mastocytosis, Systemic / genetics; Mastocytosis, Systemic / immunology; Mastocytosis, Systemic / pathology; Mastocytosis, Systemic / veterinary; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / metabolism
TL;DR: A novel mast cell line is generated from an 11-year-old spayed female Labrador retriever diagnosed with systemic mastocytosis and neoplastic effusion that possesses phenotypic and functional properties similar to those found in canine BMCMCs, and will likely be a useful tool to study mast cell biology, factors regulating transformation of mast cells, cytogenetic abnormalities in mast cell tumors, and novel preclinical therapies. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

IDH1 and IDH2 hotspot mutations are not found in canine glioma

International Journal of Cancer, 127(1), 245–246.

By: Z. Reitman*, N. Olby n, C. Mariani n, R. Thomas n, M. Breen n, D. Bigner*, R. McLendon*, H. Yan*

MeSH headings : Animals; Brain Neoplasms / genetics; Brain Neoplasms / veterinary; Dogs; Glioma / genetics; Glioma / veterinary; Isocitrate Dehydrogenase / genetics; Isoenzymes / genetics; Mutation
TL;DR: Human diffuse and anaplastic astrocytomas, well-differenti-ated and anaPLastic oligodendrogliomas and secondary glio-blastomas frequently contain somatic mutations of the R132 codon of the cytoplasmic NADPþ-dependent iso-citrate dehydrogenase (IDH1) or the corresponding R172codon in its homolog, IDH2. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2009 journal article

Influence of genetic background on tumor karyotypes: Evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma

CHROMOSOME RESEARCH, 17(3), 365–377.

By: R. Thomas n, H. Wang n, P. Tsai n, C. Langford*, S. Fosmire*, C. Jubala*, D. Getzy*, G. Cutter*, J. Modiano*, M. Breen n

author keywords: microarray; comparative genomic hybridization (CGH); canine; osteosarcoma; chromosome
MeSH headings : Animals; Chromosome Aberrations / veterinary; Comparative Genomic Hybridization; Dog Diseases / genetics; Dogs; Genetic Predisposition to Disease / genetics; Karyotyping / veterinary; Osteosarcoma / genetics; Osteosarcoma / veterinary; Species Specificity
TL;DR: Assessment of a cohort of Golden Retrievers and Rottweilers diagnosed with spontaneous appendicular osteosarcoma reveals significant correlations between breed and tumor karyotypes that are independent of gender, age at diagnosis, and histological classification. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas

CHROMOSOME RESEARCH, 17(8), 987–1000.

By: R. Thomas n, V. Valli*, P. Ellis*, J. Bell*, E. Karlsson*, J. Cullen n, K. Lindblad-Toh*, C. Langford*, M. Breen n

author keywords: microarray; comparative genomic hybridization (CGH); feline; sarcoma; chromosome
MeSH headings : Animals; Cat Diseases / diagnosis; Cats; Cytogenetic Analysis; DNA Copy Number Variations; Gene Dosage; Gene Expression Profiling; Injections / adverse effects; Oligonucleotide Array Sequence Analysis; Sarcoma / diagnosis; Sarcoma / genetics; Sarcoma / veterinary
TL;DR: Construction of a genomic microarray platform for detection of recurrent CNAs in feline tumors through cytogenetic assignment of 210 large-insert DNA clones selected at intervals of ∼15 Mb from the feline genome sequence assembly is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

ORIGINS AND EVOLUTION OF A TRANSMISSIBLE CANCER

EVOLUTION, 63(9), 2340–2349.

author keywords: Chromosomal evolution; evolutionary genomics; genetic variation; molecular evolution; population genetics; sex
MeSH headings : Animals; Biological Evolution; Comparative Genomic Hybridization / methods; Dog Diseases / genetics; Dogs / classification; Dogs / genetics; Gene Dosage; Genotype; Microarray Analysis; Microsatellite Repeats / genetics; Neoplasms / genetics; Neoplasms / veterinary; Phylogeny; Venereal Tumors, Veterinary / genetics; Wolves / genetics
TL;DR: The genetic and genomic patterns observed are typical of those expected of asexual pathogens, and the extended time since first origin may explain the many remarkable adaptations that have enabled this mammalian cell lineage to live as a unicellular pathogen. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 review

Update on Genomics in Veterinary Oncology

[Review of ]. TOPICS IN COMPANION ANIMAL MEDICINE, 24(3), 113–121.

By: M. Breen n

author keywords: cancer; genomics; oncology; technology; veterinary
MeSH headings : Animals; Cat Diseases / genetics; Cats; Dog Diseases / genetics; Dogs; Genomics / methods; Neoplasms / genetics; Neoplasms / veterinary; Veterinary Medicine / methods
TL;DR: The release of an annotated human genome sequence assembly and the emergence of genomics technologies have led to significant advances in the authors' understanding of many human diseases including cancers. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

‘Putting our heads together’: insights into genomic conservation between human and canine intracranial tumors

Journal of Neuro-Oncology, 94(3), 333–349.

By: R. Thomas n, S. Duke n, H. Wang n, T. Breen n, R. Higgins*, K. Linder n, P. Ellis*, C. Langford* ...

author keywords: Comparative genomic hybridization; Canine; Brain tumor; Chromosome; Microarray
MeSH headings : Animals; Brain Neoplasms / genetics; Brain Neoplasms / pathology; Chromosome Aberrations; Chromosome Mapping; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 22; Cluster Analysis; Dogs; Female; Gene Expression Regulation, Neoplastic; Genome / genetics; Glioma / genetics; Glioma / pathology; Humans; In Situ Hybridization, Fluorescence; Male; Meningeal Neoplasms / genetics; Meningeal Neoplasms / pathology; Meningioma / genetics; Meningioma / pathology
TL;DR: A microarray-based comparative genomic hybridization analysis of 60 spontaneous canine intracranial tumors was performed to examine the degree to which dog and human patients exhibit aberrations of ancestrally related chromosome regions, consistent with a shared pathogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

A genome assembly-integrated dog 1 Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysis

CYTOGENETIC AND GENOME RESEARCH, 122(2), 110–121.

By: R. Thomas*, S. Duke, E. Karlsson*, A. Evans*, P. Ellis*, K. Lindblad-Toh*, C. Langford*, M. Breen*

MeSH headings : Animals; Chromosomes / genetics; Comparative Genomic Hybridization; Cytogenetics; Databases, Nucleic Acid; Dogs; Genome / genetics; In Situ Hybridization, Fluorescence; Neoplasms / genetics; Oligonucleotide Array Sequence Analysis
TL;DR: The dog genome sequence assembly is used to identify a framework panel of 2,097 bacterial artificial chromosome (BAC) clones, selected at intervals of approximately one megabase, which has enormous potential for aiding gene discovery through a comparative approach to molecular oncology. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 article

Canine cytogenetics - from band to basepair

CYTOGENETIC AND GENOME RESEARCH, Vol. 120, pp. 50–60.

By: M. Breen n

MeSH headings : Animals; Base Pairing; Chromosome Banding / veterinary; Chromosome Mapping / veterinary; Chromosome Painting / veterinary; Cytogenetic Analysis / standards; Cytogenetic Analysis / veterinary; Cytogenetics; Dog Diseases / genetics; Dogs / genetics; Evolution, Molecular; Female; In Situ Hybridization, Fluorescence / veterinary; Karyotyping / veterinary; Male; Neoplasms / genetics; Neoplasms / veterinary; Nucleic Acid Hybridization
TL;DR: The role of canine cytogenetics has moved rapidly from one that served initially to define the gross genomic organization of the canine genome and provide a reliable means to determine the chromosomal location of individual genes, to one that enabled the assembled sequence of the dog genome to be anchored to the karyotype. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Enhancement of extra chromosomal recombination in somatic cells by affecting the ratio of homologous recombination (HR) to non-homologous end joining (NHEJ)

ANIMAL BIOTECHNOLOGY, 19(1), 6–21.

By: G. Zaunbrecher*, B. Mir*, P. Dunne n, M. Breen n & J. Piedrahita n

author keywords: extra chromosomal; homologous recombination; somatic cells
MeSH headings : Acetyltransferases / genetics; Animals; Cell Physiological Phenomena; Chromosomes / genetics; DNA Primers; DNA Repair; Plasmids; Recombination, Genetic; Swine; Tumor Suppressor Protein p53 / genetics
TL;DR: Results show that attempts at reducing NHEJ by use of Mre11 or anti-Ku aptamers were unsuccessful, and cell synchrony via thymidine incorporation does increase the ratio of HR/NHEJ and this indicates that this approach may be of use to facilitate targeting in somatic cells by reducing the numbers of colonies that need to be analyzed before a HR is identified. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans - man and his best friend share more than companionship

CHROMOSOME RESEARCH, 16(1), 145–154.

By: M. Breen n & J. Modiano*

author keywords: chromosome; comparative; dog; evolution; leukemia; lymphoma
MeSH headings : Animals; Chromosome Aberrations; Conserved Sequence; Cytogenetics; Dogs; Evolution, Molecular; Hematologic Neoplasms / genetics; Humans; Male; Synteny / genetics; Translocation, Genetic
TL;DR: It is suggested that humans and dogs share an ancestrally retained pathogenetic basis for cancer and that cytogenetic evaluation of canine tumors may provide greater insight into the biology of tumorigenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Tackling the characterization of canine chromosomal breakpoints with an integrated in-situ/in-silico approach: The canine PAR and PAB

CHROMOSOME RESEARCH, 16(8), 1193–1202.

By: A. Young n, E. Kirkness* & M. Breen n

author keywords: Canis familiaris; chromosomal breakpoints; dog; PAR; PAB
MeSH headings : Animals; Chromosome Breakage; Chromosome Mapping / methods; Chromosomes, Artificial, Bacterial; Chromosomes, Mammalian / genetics; Dogs / genetics; X Chromosome / genetics
TL;DR: This study demonstrates the synergy of using a such a combined in-situ/in-silico approach to define chromosome breakpoints using the naturally occurring breakpoint present on all canine X chromosomes—the pseudoautosomal breakpoint (PAB). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 article

A cytogenetically characterized, genome-anchored 10-Mb BAC set and CGH array for the domestic dog

JOURNAL OF HEREDITY, Vol. 98, pp. 474–484.

By: R. Thomas n, S. Duke n, S. Bloom n, T. Breen n, A. Young n, E. Feiste n, E. Seiser n, P. Tsai n ...

MeSH headings : Animals; Chromosome Mapping; Chromosomes, Artificial, Bacterial / genetics; Dogs / genetics; Genome; In Situ Hybridization, Fluorescence; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Sensitivity and Specificity
TL;DR: The value of a combined aCGH/FISH approach, together with a well-annotated dog genome assembly, in canine and comparative cancer studies is outlined. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

A novel canine lymphoma cell line: A translational and comparative model for lymphoma research

LEUKEMIA RESEARCH, 31(12), 1709–1720.

By: W. Kisseberth*, M. Nadella*, M. Breen n, R. Thomas n, S. Duke n, S. Murahari*, C. Kosarek*, W. Vernau* ...

author keywords: canine lymphoma; cell line; array comparative genomic hybridization; bioluminescent imaging; xenograft
MeSH headings : Animals; Biomedical Research; Cell Line, Tumor; Dogs; Immunophenotyping; Lymphoma / pathology; Mice; Mice, SCID; Neoplasm Transplantation; Transplantation, Heterologous
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 review

Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences

[Review of ]. NATURE, 447(7141), 167–U1.

By: T. Mikkelsen, M. Wakefield, B. Aken, C. Amemiya, J. Chang, S. Duke, M. Garber, A. Gentles ...

MeSH headings : Animals; Base Composition; Conserved Sequence / genetics; DNA Transposable Elements / genetics; Evolution, Molecular; Genome / genetics; Genomics; Humans; Opossums / genetics; Polymorphism, Single Nucleotide / genetics; Protein Biosynthesis; Synteny / genetics; X Chromosome Inactivation / genetics
TL;DR: A high-quality draft of the genome sequence of the grey, short-tailed opossum is reported, indicating a strong influence of biased gene conversion on nucleotide sequence composition, and a relationship between chromosomal characteristics and X chromosome inactivation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-Cell lymphoma

VETERINARY PATHOLOGY, 44(4), 467–478.

By: S. Fosmire*, R. Thomas n, C. Jubala*, J. Wojcieszyn, V. Valli*, D. Getzy*, T. Smith*, L. Gardner* ...

author keywords: canines; cell cycle; non-Hodgkin's lymphoma; tumor suppressor genes
MeSH headings : Animals; Cyclin-Dependent Kinase Inhibitor p16 / genetics; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Dog Diseases / metabolism; Dogs; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Lymphoma, B-Cell / metabolism; Lymphoma, B-Cell / veterinary; Lymphoma, T-Cell / metabolism; Lymphoma, T-Cell / veterinary; Male; Retinoblastoma Protein / genetics; Retinoblastoma Protein / metabolism
TL;DR: The data show that p16 deletion or inactivation occurs almost exclusively in high-grade T-cell NHL; however, alternative pathways can generate functional phenotypes of Rb deficiency in low-grade Hodgkin's lymphoma and inHigh-grade B- cell NHL. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Integrated cytogenetic BAC map of the genome of the gray, short-tailed opossum, Monodelphis domestica

CHROMOSOME RESEARCH, 15(3), 361–370.

By: S. Duke, P. Samollow*, E. Mauceli*, K. Lindblad-Toh* & M. Breen n

author keywords: chromosome; cytogenetic; genome; map; Monodelphis
MeSH headings : Animals; Base Sequence; Chromosome Mapping / methods; Chromosomes, Artificial, Bacterial; Cytogenetics / methods; Genome / genetics; Genomics / methods; In Situ Hybridization, Fluorescence; Monodelphis / genetics
TL;DR: The molecular cytogenetic locations of 415 bacterial artificial chromosome clones that served to anchor sequence scaffolds of the gray, short-tailed opossum to its karyotype were reported, which enabled accurate integration of these regions into the genome assembly. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphoma

Leukemia, 21(1), 184–187.

By: J. Modiano*, M. Breen n, V. Valli*, J. Wojcieszyn & G. Cutter*

MeSH headings : Age of Onset; Animals; Disease Models, Animal; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Gene Silencing; Genes, Retinoblastoma; Genes, p16; Genetic Predisposition to Disease; Lymphoma, Non-Hodgkin / genetics; Lymphoma, Non-Hodgkin / physiopathology; Lymphoma, Non-Hodgkin / veterinary; Predictive Value of Tests; Species Specificity
TL;DR: Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphoma is predicted to be low. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: September 18, 2021

2007 journal article

The search for a marsupial XIC reveals a break with vertebrate synteny

Chromosome Research, 15(2), 137–146.

By: L. Davidow*, M. Breen n, S. Duke n, P. Samollow*, J. McCarrey* & J. Lee*

author keywords: marsupial; Monodelphis domestica; noncoding RNA; TSIX; X-chromosome; XIC; X inactivation center; XIST
MeSH headings : Animals; Chromosome Walking; Computational Biology; Cytogenetic Analysis; DNA-Binding Proteins / genetics; Evolution, Molecular; Female; Genes, X-Linked; Genomics; Humans; Male; Monocarboxylic Acid Transporters / genetics; Monodelphis / genetics; RNA, Long Noncoding; RNA, Untranslated / genetics; Symporters; Synteny; Transcription Factors / genetics; Vertebrates / genetics; X Chromosome; X Chromosome Inactivation
TL;DR: The failure to find XIST/TSIX in M. domestica may suggest that the ancestral XIC is too divergent to allow for detection by current methods, and argues that marsupial XCI does not require XIST and opens the search for alternative mechanisms of dosage compensation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science
Added: August 6, 2018

2006 personal communication

The dog as a cancer model

Khanna, C., Lindblad-Toh, K., Vail, D., London, C., Bergman, P., Barber, L., … Withrow, S. (2006, September).

By: C. Khanna*, K. Lindblad-Toh*, D. Vail*, C. London*, P. Bergman*, L. Barber*, M. Breen n, B. Kitchell* ...

MeSH headings : Animals; Disease Models, Animal; Dogs; Humans; Neoplasms / physiopathology; Neoplasms / veterinary
TL;DR: Rather than arguing for the importance of long-term database funding by granting agencies, BIND’s saga in fact argues for greater caution and more demanding oversight when these agencies elect to fund a database‘s initial development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Nature, 438(7069), 803–819.

By: K. Lindblad-Toh, C. Wade, T. Mikkelsen, E. Karlsson, D. Jaffe, M. Kamal, M. Clamp, J. Chang ...

MeSH headings : Animals; Conserved Sequence / genetics; Dog Diseases / genetics; Dogs / classification; Dogs / genetics; Evolution, Molecular; Female; Genome / genetics; Genomics; Haplotypes / genetics; Humans; Hybridization, Genetic; Male; Mice; Mutagenesis / genetics; Polymorphism, Single Nucleotide / genetics; Rats; Short Interspersed Nucleotide Elements / genetics; Synteny / genetics
TL;DR: A high-quality draft genome sequence of the domestic dog is reported, together with a dense map of single nucleotide polymorphisms (SNPs) across breeds, to shed light on the structure and evolution of genomes and genes. (via Semantic Scholar)
Sources: Crossref, Web Of Science
Added: August 6, 2018

2004 journal article

A high-resolution comparative map of canine Chromosome 5q14.3–q33 constructed utilizing the 1.5× canine genomesequence

Mammalian Genome, 15(7), 544–551.

By: K. Comstock*, F. Lingaas*, E. Kirkness, C. Hitte*, R. Thomas*, M. Breen n, F. Galibert*, E. Ostrander*

MeSH headings : Animals; Chromosome Mapping; Chromosomes / ultrastructure; Chromosomes, Artificial, Bacterial; Crosses, Genetic; DNA / metabolism; DNA Primers / chemistry; Dogs; Gene Library; Genetic Linkage; Genetic Predisposition to Disease; Genome; Genome, Human; Genotype; Humans; Microsatellite Repeats; Models, Genetic; Polymorphism, Single Nucleotide; Species Specificity
TL;DR: This current mapping effort on CFA5 expands the degree to which initial findings of linkage in canine families can be followed by successful positional cloning efforts and increases the value of the human genome sequence for defining candidate genes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
15. Life on Land (Web of Science)
Sources: Crossref, Web Of Science
Added: August 6, 2018

2004 journal article

Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium

Laboratory Investigation, 84(5), 562–572.

By: S. Fosmire*, E. Dickerson*, A. Scott n, S. Bianco*, M. Pettengill n, H. Meylemans*, M. Padilla*, A. Frazer-Abel* ...

author keywords: canine; endothelial cells; angiosarcoma; angiogenesis; CD117; NFAT; nicotine
MeSH headings : Animals; Antigens, CD / metabolism; Cell Adhesion; Cell Division; Cell Line, Tumor; Cell Movement; DNA, Neoplasm / analysis; DNA, Neoplasm / genetics; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Endothelium, Vascular / pathology; Hemangiosarcoma / blood supply; Hemangiosarcoma / pathology; Hemangiosarcoma / physiopathology; Hemangiosarcoma / veterinary; Humans; Models, Biological; Neovascularization, Pathologic; Ploidies; Vascular Endothelial Growth Factor A / metabolism
TL;DR: It is shown that expression of CD117 (c-Kit) can distinguish primitive (malignant) from mature (benign) proliferative endothelial lesions, and eight independent cell lines derived from canine HSA explants are described. (via Semantic Scholar)
Sources: Crossref, Web Of Science
Added: August 6, 2018

journal article

A comprehensive genomic history of extinct and living elephants

Palkopoulou, E., Lipson, M., Mallick, S., Nielsen, S., Rohland, N., Baleka, S., … Meller, H. Proceedings of the National Academy of Sciences of the United States of America, 115(11), E2566–2574.

By: E. Palkopoulou, M. Lipson, S. Mallick, S. Nielsen, N. Rohland, S. Baleka, E. Karpinski, A. Ivancevici ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients

LeBlanc, A. K., Mazcko, C., Brown, D. E., Koehler, J. W., Miller, A. D., Miller, C. R., … Dickinson, P. J. Neuro-Oncology, 18(9), 1209–1218.

By: A. LeBlanc, C. Mazcko, D. Brown, J. Koehler, A. Miller, C. Miller, R. Bentley, R. Packer ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Cytogenetic BAC map of the genome of Monodelphis domestica

Duke, S. E., Samallow, P., Mauceli, E., Lindblad-Toh, K., & Breen, M. Chromosome Research, 15, 3610–3670.

By: S. Duke, P. Samallow, E. Mauceli, K. Lindblad-Toh & M. Breen

Source: NC State University Libraries
Added: August 6, 2018

journal article

Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background

Elvers, I., Turner-Maier, J., Swofford, R., Koltookian, M., Johnson, J., Stewart, C., … Lindblad-Toh, K. Genome Research, 25(11), 1634–1645.

By: I. Elvers, J. Turner-Maier, R. Swofford, M. Koltookian, J. Johnson, C. Stewart, C. Zhang, S. Schumacher ...

Source: NC State University Libraries
Added: August 6, 2018

review

Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences

Mikkelsen, T. S., Wakefield, M. J., Aken, B., Amemiya, C. T., Chang, J. L., Duke, S., … al. [Review of ]. 254, 447(7141), 167–161.

By: T. Mikkelsen, M. Wakefield, B. Aken, C. Amemiya, J. Chang, S. Duke, M. Garber, A. Gentles ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Rivera, P. Genome Biology, 14(12).

By: E. Karlsson, S. Sigurdsson, E. Ivansson, R. Thomas, I. Elvers, J. Wright, C. Howald, N. Tonomura ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers

Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Kim, J. H. PLoS Genetics, 11(2).

By: N. Tonomura, I. Elvers, R. Thomas, K. Megquier, J. Turner-Maier, C. Howald, A. Sarver, R. Swofford ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Molecular profiling reveals prognostically significant subtypes of canine lymphoma

Frantz, A. M., Sarver, A. L., Ito, D., Phang, T. L., Karimpour-Fard, A., Scott, M. C., … O'Brien, T. D. Veterinary Pathology, 50(4), 693–703.

By: A. Frantz, A. Sarver, D. Ito, T. Phang, A. Karimpour-Fard, M. Scott, V. Valli, K. Lindblad-Toh ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Naturally occurring translational models for development of cancer gene therapy

Modiano, J. F., Breen, M., Lana, S. E., Ehrhart, N., Fosmire, S. P., Thomas, R., … Bellgrau, D. Gene Therapy & Molecular Biology, 10A, 31–40.

By: J. Modiano, M. Breen, S. Lana, N. Ehrhart, S. Fosmire, R. Thomas, C. Jubala, A. Lamerato-Kozicki ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology

LeBlanc, A. K., Breen, M., Choyke, P., Dewhirst, M., Fan, T. M., Gustafson, D. L., … Trent, J. M. Science Translational Medicine, 8(324).

By: A. LeBlanc, M. Breen, P. Choyke, M. Dewhirst, T. Fan, D. Gustafson, L. Helman, M. Kastan ...

Source: NC State University Libraries
Added: August 6, 2018

personal communication

Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphoma

Modiano, J. F., Breen, M., O Valli, V. E., Wojcieszyn, J. W., & Cutter, G. R.

By: J. Modiano, M. Breen, V. O Valli, J. Wojcieszyn & G. Cutter

Source: NC State University Libraries
Added: August 6, 2018

journal article

SETD2 is recurrently mutated in whole-exome sequenced canine osteosarcoma

Sakthikumar, S., Elvers, I., Kim, J., Arendt, M. L., Thomas, R., Turner-Maier, J., … Modiano, J. F. Cancer Research, 78(13), 3421–3431.

By: S. Sakthikumar, I. Elvers, J. Kim, M. Arendt, R. Thomas, J. Turner-Maier, R. Swofford, J. Johnson ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Safe and effective sarcoma therapy through bispecific targeting of EGFR and uPAR

Borgatti, A., Koopmeiners, J. S., Sarver, A. L., Winter, A. L., Stuebner, K., Todhunter, D., … Oh, F. Molecular Cancer Therapeutics, 16(5), 956–965.

By: A. Borgatti, J. Koopmeiners, A. Sarver, A. Winter, K. Stuebner, D. Todhunter, A. Rizzardi, J. Henriksen ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer

Shearin, A. L., Hedan, B., Cadieu, E., Erich, S. A., Schmidt, E. V., Faden, D. L., … Andre, C. Cancer Epidemiology Biomarkers, 21(7), 1019–1027.

By: A. Shearin, B. Hedan, E. Cadieu, S. Erich, E. Schmidt, D. Faden, J. Cullen, J. Abadie ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

The genome of the green anole lizard and a comparative analysis with birds and mammals

Alfoldi, J., Di Palma, F., Grabherr, M., Williams, C., Kong, L. S., Mauceli, E., … Moreno, R. G. Nature, 477(7366), 587–591.

By: J. Alfoldi, F. Di Palma, M. Grabherr, C. Williams, L. Kong, E. Mauceli, P. Russell, C. Lowe ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Three crocodilian genomes reveal ancestral patterns of evolution among archosaurs

Green, R. E., Braun, E. L., Armstrong, J., Earl, D., Nguyen, N., Hickey, G., … Hubley, R. M. Science, 346(6215), 1335-.

By: R. Green, E. Braun, J. Armstrong, D. Earl, N. Nguyen, G. Hickey, M. Vandewege, J. St John ...

Source: NC State University Libraries
Added: August 6, 2018

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