Matthew Breen

comprative genomics, cancer research, cytogenetics, canine cancer, genomics, genome mapping, comparative oncology

Works (220)

Updated: January 24th, 2025 05:10

2025 article

Environmental Exposures and Canine Bladder Cancer: A Case Control Study Using Silicone Passive Samplers

Wise, C. F., Herkert, N. J., Hoffman, K., Vaden, S., Breen, M., & Stapleton, H. M. (2025, January 9). ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol. 1.

By: C. Wise *, N. Herkert *, K. Hoffman *, S. Vaden n , M. Breen n  & H. Stapleton *

author keywords: dog; exposure assessment; silicone wristband; passive sampling; bladder cancer; environmentalmixtures
Sources: Web Of Science, NC State University Libraries
Added: January 21, 2025

2024 journal article

Contrasting pathogen prevalence between tick and dog populations at Chornobyl

PARASITES & VECTORS, 17(1).

By: M. Dillon n, B. Qurollo n , R. Thomas n, M. Warren n, T. Mousseau *, J. Betz *, N. Kleiman *, M. Breen n 

author keywords: Chernobyl; Chornobyl; <italic>Ixodes ricinus</italic>; Ticks; Tick-borne pathogens; Zoonotic pathogens; Free-breeding dogs; Quantitative PCR; Droplet digital PCR
Sources: Web Of Science, NC State University Libraries
Added: November 25, 2024

2024 journal article

Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion

CANCER RESEARCH COMMUNICATIONS, 4(6), 1467–1480.

By: J. Kim *, A. Schulte *, A. Sarver *, D. Lee *, M. Angelos *, A. Frantz *, C. Forster *, . Timothy D. O'Brien * ...

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Sources: Web Of Science, NC State University Libraries
Added: July 17, 2024

2024 journal article

Is increased mutation driving genetic diversity in dogs within the Chornobyl exclusion zone?

PLOS ONE, 19(12).

By: M. Dillon n, A. Dickey n, R. Roberts n , J. Betz *, T. Mousseau *, N. Kleiman *, M. Breen n 

Sources: Web Of Science, NC State University Libraries
Added: January 13, 2025

2024 journal article

Molecular Discovery of Filarial Nematode <scp>DNA</scp> in an Endangered Wild Pinniped (Galapagos Sea Lion, <i>Zalophus wollebaeki</i>)

Ecology and Evolution, 14(11).

By: I. Livingston n, T. Gregory n, E. Hawkins n , A. Cave n, A. Loyola*, S. Vaden n , D. Deresienski n, M. Riofrío‐Lazo * ...

author keywords: endangered species; Galapagos; heartworm; introduced species; pathogen detection; sea lion
Sources: Web Of Science, NC State University Libraries, Crossref
Added: December 16, 2024

2024 journal article

The development of non-destructive sampling methods of parchment skins for genetic species identification

PLOS ONE, 19(3).

By: M. Scheible n, T. Stinson n , M. Breen n , B. Callahan n , R. Thomas n & K. Meiklejohn n 

Ed(s): A. Shakoori

TL;DR: A workflow for enriching the mitochondrial genome (mtGenome), generating next-generation sequencing reads to permit species identification, and providing interpretation guidance is defined, defining a workflow for enriching the mitochondrial genome, generating next-generation sequencing reads to permit species identification, and providing interpretation guidance. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 22, 2024

2023 article

Defining the relevance of surgical margins. Part two: Strategies to improve prediction of recurrence risk

Bray, J., Eward, W., & Breen, M. (2023, February 15). VETERINARY AND COMPARATIVE ONCOLOGY, Vol. 2.

By: J. Bray, W. Eward* & M. Breen n 

author keywords: genetics; pathology; small animal; surgical oncology; tumour biology
MeSH headings : Animals; Cats; Dogs; Margins of Excision; Neoplasm, Residual / pathology; Neoplasm, Residual / veterinary; Cat Diseases / surgery; Neoplasm Recurrence, Local / veterinary; Dog Diseases / surgery
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Sources: Web Of Science, NC State University Libraries
Added: March 13, 2023

2023 journal article

Dirofilaria immitis Identified in Galapagos Sea Lions (Zalophus wollebaeki): A Wildlife Health and Conservation Concern

Journal of Wildlife Diseases, 59(3), 487–494.

By: T. Gregory n, I. Livingston n, E. Hawkins n , A. Loyola*, A. Cave n, S. Vaden n , D. Deresienski n, M. Breen n  ...

author keywords: Dirofilaria immitis; Galapagos Islands; heartworm; Zalophus wollebaeki
MeSH headings : Animals; Dogs; Male; Sea Lions; Dirofilaria immitis; Animals, Wild; Caniformia; Animals, Domestic; Endangered Species; Dirofilariasis / epidemiology; Dog Diseases
TL;DR: This is the first report of D. immitis infection in Galapagos sea lions, and widespread adoption of routine heartworm testing, prevention, and treatment in the canine population, and the control of mosquitos, could potentially reduce the disease impact on this endangered pinniped species. (via Semantic Scholar)
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14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 14, 2023

2023 journal article

The dogs of Chernobyl: Demographic insights into populations inhabiting the nuclear exclusion zone

SCIENCE ADVANCES, 9(9).

By: G. Spatola *, R. Buckley *, M. Dillon n, E. V. Dutrow *, J. Betz *, M. Pilot *, H. Parker *, W. Bogdanowicz * ...

MeSH headings : Dogs; Animals; Chernobyl Nuclear Accident; Environment; Disasters; Environmental Pollution; Demography
TL;DR: This study presents the first characterization of a domestic species in Chernobyl, establishing their importance for genetic studies into the effects of exposure to long-term, low-dose ionizing radiation. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023

2023 journal article

Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation: Short in-frame deletions in BRAF and MAP2K1 suggest alternative mechanisms for MAPK pathway disruption

PLOS GENETICS, 19(4).

By: R. Thomas n, C. Wiley n, E. Droste n, J. Robertson n , B. Inman * & M. Breen n 

Ed(s): T. Leeb

MeSH headings : Dogs; Animals; Humans; Urinary Bladder Neoplasms / genetics; Urinary Bladder Neoplasms / veterinary; Carcinoma, Transitional Cell / genetics; Carcinoma, Transitional Cell / veterinary; Proto-Oncogene Proteins B-raf / genetics; Exome Sequencing; Mutation; MAP Kinase Kinase 1 / genetics
TL;DR: It is suggested that short in-frame deletions within BRAF exon 12 and MAP2K1 exons 2 and 3 in UDV595E cases are alternative MAPK-pathway activating events that may have significant therapeutic implications for selecting first-line treatment for canine UC. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 15, 2023

2022 article

Evaluating the relevance of surgical margins. Part one: The problems with current methodology

Bray, J., Eward, W., & Breen, M. (2022, November 25). VETERINARY AND COMPARATIVE ONCOLOGY, Vol. 11.

By: J. Bray, W. Eward* & M. Breen n 

author keywords: genetics'; pathology; small animal; surgical oncology; tumour biology
MeSH headings : Animals; Margins of Excision; Neoplasm Recurrence, Local / veterinary; Retrospective Studies
TL;DR: The challenges with defining the true extent of the tumours margin from the perspective of the surgeon, the pathologist and the tumour are described and why current efforts to ensure that all traces of the local tumour have been successfully removed may provide an imperfect assessment of the risk of recurrence. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: December 12, 2022

2022 article

Inter-pathologist agreement on diagnosis, classification and grading of canine glioma

Krane, G. A., Shockley, K. R., Malarkey, D. E., Miller, A. D., Miller, C. R., Tokarz, D. A., … Mariani, C. L. (2022, July 30). VETERINARY AND COMPARATIVE ONCOLOGY, Vol. 7.

By: G. Krane  n, K. Shockley *, D. Malarkey*, A. Miller *, C. Miller *, D. Tokarz n, H. Jensen *, K. Janardhan *, M. Breen n , C. Mariani n 

author keywords: brain; cancer; dog; histopathology; immunohistochemistry
MeSH headings : Humans; Animals; Dogs; Oligodendroglioma / diagnosis; Oligodendroglioma / veterinary; Oligodendroglioma / pathology; Pathologists; Dog Diseases / diagnosis; Dog Diseases / pathology; Glioma / diagnosis; Glioma / veterinary; Glioma / pathology; Astrocytoma / veterinary; Brain Neoplasms / diagnosis; Brain Neoplasms / veterinary; Brain Neoplasms / pathology
TL;DR: Inter‐pathologist agreement utilising CBTC guidelines for canine glioma was moderate overall but varied from fair to almost perfect between pairs of pathologists, similar for oligodendrogliomas and astrocytomas but lower for undefined gliomas. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 8, 2022

2022 journal article

The AGMK1-9T7 cell model of neoplasia: Evolution of DNA copy-number aberrations and miRNA expression during transition from normal to metastatic cancer cells

PLOS ONE, 17(10).

By: A. Lewis *, R. Thomas*, M. Breen* , K. Peden*, B. Teferedegne*, G. Foseh*, A. Motsinger-Reif n, D. Rotroff n, G. Lewis

MeSH headings : Animals; Humans; Chlorocebus aethiops; MicroRNAs / genetics; MicroRNAs / metabolism; Neoplasms / genetics; Carcinogenesis / genetics; DNA Copy Number Variations / genetics; Chromosome Aberrations; Neoplasms, Second Primary / genetics; DNA; Gene Expression Regulation, Neoplastic; Gene Expression Profiling
TL;DR: The evolution of chromosomal DNA copy-number aberrations and miRNA expression in this cell line from passage 1 to the acquisition of a tumorigenic phenotype at passage 40 is examined and it is proposed that the evolution of AGMK1-9T7 cells represents a detailed model of neoplasia in vitro. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 27, 2023

2022 article

Transcriptome annotation reveals minimal immunogenetic diversity among Wyoming toads, Anaxyrus baxteri

Carlson, K. B., Wcisel, D. J., Ackerman, H. D., Romanet, J., Christiansen, E. F., Niemuth, J. N., … Yoder, J. A. (2022, April 28). CONSERVATION GENETICS, Vol. 4.

By: K. Carlson n, D. Wcisel n, H. Ackerman  n, J. Romanet n, E. Christiansen n, J. Niemuth n , C. Williams n, M. Breen n  ...

author keywords: Amphibian; Bufonidae; Immunogenetics; MHC; TLR; Transcriptomics
TL;DR: Comparison transcriptomics is used to examine the diversity of toll-like receptors and major histocompatibility complex sequences across three individual Wyoming toads and finds reduced diversity at MHC genes compared to bufonid species with a similar history of bottleneck events. (via Semantic Scholar)
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15. Life on Land (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 29, 2022

2021 article

Comparative Assessment of Pesticide Exposures in Domestic Dogs and Their Owners Using Silicone Passive Samplers and Biomonitoring

Wise, C. F., Hammel, S. C., Herkert, N. J., Ospina, M., Calafat, A. M., Breen, M., & Stapleton, H. M. (2021, December 29). ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol. 12.

By: C. Wise *, S. Hammel *, N. Herkert *, M. Ospina *, A. Calafat *, M. Breen n , H. Stapleton *

author keywords: exposure; wristband; silicone; biomonitoring; pesticide; dog
MeSH headings : Animals; Biological Monitoring; Chlorpyrifos; Dogs; Environmental Exposure / analysis; Environmental Monitoring; Humans; Pesticides / analysis; Silicones
TL;DR: It is suggested that people and their dogs have similar pesticide exposures in a home environment as well as targeted gas chromatography-mass spectrometry analyses suggest. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 18, 2022

2021 journal article

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions

MOLECULAR CANCER RESEARCH, 19(5), 847–861.

By: J. Kim *, K. Megquier *, R. Thomas n, A. Sarver *, J. Song*, Y. Kim*, N. Cheng *, A. Schulte * ...

MeSH headings : Animals; Dog Diseases / genetics; Dogs; Gene Expression Profiling / methods; Gene Fusion; Genomics / methods; Hemangiosarcoma / genetics; Humans; Transcription, Genetic; Vascular Neoplasms / genetics
TL;DR: While drive events of malignant vasoformative tumors of humans and dogs include diverse mutations and stochastic rearrangements that create novel fusion genes, convergent transcriptional programs govern the highly conserved morphologic organization and biological behavior of these tumors in both species. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021

2021 article

Hi-C scaffolded short- and long-read genome assemblies of the California sea lion are broadly consistent for syntenic inference across 45 million years of evolution

Peart, C. R., Williams, C., Pophaly, S. D., Neely, B. A., Gulland, F. M. D., Adams, D. J., … Wolf, J. B. W. (2021, June 27). MOLECULAR ECOLOGY RESOURCES, Vol. 6.

By: C. Peart *, C. Williams n, S. Pophaly*, B. Neely *, F. Gulland *, D. Adams *, B. Ng *, W. Cheng * ...

author keywords: California sea lion (Zalophus californianus); cancer; Carnivora; chromatin interaction mapping; genome assembly; genome evolution; Hi-C
MeSH headings : Animals; Dogs; Ferrets; Genome; Sea Lions / genetics; Synteny; X Chromosome
TL;DR: This study presents high-quality genomes of an emerging cancer model and highlights that even highly fragmented short-read assemblies scaffolded with Hi-C can yield reliable chromosome level scaffolds suitable for comparative genomic analyses. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021

2021 journal article

Phase I/II Trial of Vemurafenib in Dogs with Naturally Occurring, BRAF-mutated Urothelial Carcinoma

MOLECULAR CANCER THERAPEUTICS, 20(11), 2177–2188.

By: P. Rossman*, T. Zabka, A. Ruple *, D. Tuerck *, J. Ramos-Vara*, L. Liu, R. Mohallem *, M. Merchant ...

MeSH headings : Adolescent; Animals; Carcinoma, Transitional Cell / drug therapy; Carcinoma, Transitional Cell / pathology; Child; Disease Models, Animal; Dogs; Humans; Mutation; Proto-Oncogene Proteins B-raf / drug effects; Vemurafenib / pharmacology; Vemurafenib / therapeutic use
TL;DR: The safety, antitumor activity, and cutaneous pharmacodynamic effects of vemurafenib, and the development of drug resistance in dogs closely mimic those reported in humans, which suggests BRAF-mutated canine InvUC offers an important complementary animal model to improve BRAf-targeted therapies in humans. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 23, 2021

2021 journal article

Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species

PLOS COMPUTATIONAL BIOLOGY, 17(9).

By: G. Tawa *, J. Braisted *, D. Gerhold *, G. Grewal*, C. Mazcko*, M. Breen n , G. Sittampalam *, A. LeBlanc *

MeSH headings : Animals; Biomarkers, Tumor / genetics; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Computational Biology; Dog Diseases / classification; Dog Diseases / genetics; Dogs; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Lung Neoplasms / genetics; Lung Neoplasms / veterinary; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / veterinary; Lymphoma, T-Cell / genetics; Lymphoma, T-Cell / veterinary; Melanoma / genetics; Melanoma / veterinary; Molecular Sequence Annotation; Molecular Targeted Therapy; Neoplasms / classification; Neoplasms / genetics; Neoplasms / veterinary; Oncogenes; Osteosarcoma / genetics; Osteosarcoma / veterinary; Species Specificity; Translational Research, Biomedical
TL;DR: An experimental-bioinformatic protocol is developed that analyzes canine transcriptomics data in the context of existing human data to evaluate comparative relevance of canine to human cancer, and demonstrates transferability of classification models from canines to humans. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022

2020 article

A comparative oncology approach to biomarker and drug discovery for cancer diagnosis and treatment in dogs and humans

LeBlanc, A. K., Mazcko, C. N., Breen, M., Thomas, R., & Thamm, D. H. (2020, August). CANCER RESEARCH, Vol. 80.

By: A. LeBlanc *, C. Mazcko*, M. Breen n , R. Thomas n & D. Thamm *

TL;DR: This work exemplifies the type of approach meant to further establish the comparative relevance of canine to human cancer and provide opportunities to explore hypotheses related to detection and treatment in both species. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 8, 2021

2020 journal article

Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(12), 7409–7419.

By: C. Wise n, S. Hammel *, N. Herkert *, J. Ma n, A. Motsinger-Reif*, H. Stapleton *, M. Breen n 

MeSH headings : Animals; Biomarkers; Dogs; Environmental Monitoring; Humans; Organophosphates; Silicones
TL;DR: Exposures among pet dogs and their owners using silicone dog tags and wristbands were evaluated to determine if contaminant levels were correlated with validated biomarkers and the value of using silicone bands with dogs to investigate health impacts on humans from shared exposures is supported. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 13, 2020

2020 journal article

Development of a Genome-Wide Oligonucleotide Microarray Platform for Detection of DNA Copy Number Aberrations in Feline Cancers

VETERINARY SCIENCES, 7(3).

By: R. Thomas n, J. Pontius*, L. Borst n  & M. Breen n 

author keywords: feline; cat; cancer; genomics; chromosome; comparative genomic hybridization (CGH)
TL;DR: A microarray platform that allows rapid and sensitive detection of DNA copy number aberrations in feline tumors using comparative genomic hybridization analysis is developed and shown to have diverse potential to incorporate domestic cat cancers into comparative and translational research efforts in molecular oncology. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020

2020 article

Molecular mechanisms that activate convergent oncogenic pathway in genomically complex angiosarcoma

Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Schulte, A. J., Wang, C., … Modiano, J. F. (2020, August). CANCER RESEARCH, Vol. 80.

By: J. Kim *, K. Megquier *, A. Sarver *, R. Thomas n, A. Schulte *, C. Wang *, I. Elvers *, E. Karlsson * ...

TL;DR: The data suggests that genomic instability induced by TP53 mutations might create a predisposition for fusion events that may contribute to tumor progression by promoting selection and/or enhancing fitness through activation of convergent angiogenic pathways. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 8, 2021

2020 journal article

PTPN11mutations in canine and human disseminated histiocytic sarcoma

INTERNATIONAL JOURNAL OF CANCER, 147(6), 1657–1665.

By: B. Hedan *, M. Rault*, J. Abadie *, R. Ulve*, N. Botherel*, P. Devauchelle, C. Copie-Bergman *, E. Cadieu* ...

author keywords: histiocytic sarcoma; dog; spontaneous model; PTPN11
MeSH headings : Adult; Aged; Aged, 80 and over; Animals; Biopsy; Cell Line, Tumor; Cell Proliferation / drug effects; Child; Child, Preschool; DNA Mutational Analysis; Disease Models, Animal; Dog Diseases / blood; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Drug Screening Assays, Antitumor / methods; Female; Histiocytes / pathology; Histiocytic Sarcoma / drug therapy; Histiocytic Sarcoma / genetics; Histiocytic Sarcoma / pathology; Histiocytic Sarcoma / veterinary; Humans; Infant; MAP Kinase Signaling System / drug effects; MAP Kinase Signaling System / genetics; Male; Middle Aged; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / metabolism; Mutation; Protein Kinase Inhibitors / pharmacology; Protein Kinase Inhibitors / therapeutic use; Protein Tyrosine Phosphatase, Non-Receptor Type 11 / antagonists & inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 11 / genetics; Ribonucleases; Tumor Suppressor Proteins; Young Adult
TL;DR: Results illustrate the relevance of naturally affected dogs in deciphering genetic mechanisms and selecting efficient targeted therapies for such rare and aggressive cancers in humans, by testing drugs targeting the MAPK pathway in eight canine HS cell lines. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020

2020 journal article

Use of standardized bioinformatics for the analysis of fungal DNA signatures applied to sample provenance

FORENSIC SCIENCE INTERNATIONAL, 310.

By: J. Allwood n, N. Fierer *, R. Dunn n , M. Breen n , B. Reich n , E. Laber n, J. Clifton n, N. Grantham n, S. Faith n

author keywords: Forensic microbiology; Bioinformatics; Metabarcoding; Sample provenance
MeSH headings : DNA Barcoding, Taxonomic; DNA, Fungal / chemistry; Demography; Forensic Sciences; Fungi; Humans; Reference Values; Soil
TL;DR: Investigating a small-scale approach as an adaptation of a larger metabarcoding study to develop a model for global sample provenance using fungal DNA signatures collected from dust swabs to facilitate a standardized method for consistent, reproducible sample treatment. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020

2019 journal article

Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma

MOLECULAR CANCER RESEARCH, 17(12), 2410–2421.

By: K. Megquier *, J. Turner-Maier *, R. Swofford *, J. Kim *, A. Sarver *, C. Wang *, S. Sakthikumar *, J. Johnson * ...

MeSH headings : Animals; Blood Vessels / pathology; Breast / metabolism; Breast / pathology; Class I Phosphatidylinositol 3-Kinases / genetics; Class Ia Phosphatidylinositol 3-Kinase / genetics; Cyclin-Dependent Kinase Inhibitor p15 / genetics; Cyclin-Dependent Kinase Inhibitor p16 / genetics; Dogs; Female; Genome / genetics; Genomics; Hemangiosarcoma / genetics; Hemangiosarcoma / pathology; Humans; Mutation / genetics; Tumor Suppressor Protein p53 / genetics; Viscera / metabolism; Viscera / pathology; Exome Sequencing
TL;DR: Canine hemangiosarcoma closely models the genomic landscape of human angiosarComa of the breast and viscera, and is a powerful tool for investigating the pathogenesis of this devastating disease. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 30, 2019

2019 journal article

Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex

CHROMOSOME RESEARCH, 27(3), 179–202.

By: K. Kennedy n, R. Thomas n, J. Durrant n, T. Jiang n, A. Motsinger-Reif n & M. Breen n 

author keywords: Histiocytic sarcoma; Chromothripsis; MMP9; Aurora kinase; Dendritic cell sarcoma
MeSH headings : Animals; Chromosome Disorders; DNA Copy Number Variations / genetics; Dog Diseases / diagnosis; Dog Diseases / genetics; Dogs; Gene Expression Profiling; Genome / genetics; Histiocytic Disorders, Malignant / diagnosis; Histiocytic Disorders, Malignant / genetics; Histiocytic Disorders, Malignant / veterinary; Humans; Immunohistochemistry / methods; Matrix Metalloproteinase 9 / metabolism; Spindle Apparatus / pathology
TL;DR: Droplet digital PCR evaluation of these regions in numerous cancer specimens effectively discriminated HM from other common round cell tumors, including lymphoma and hemangiosarcoma, resulting in a novel, rapid diagnostic aid for veterinary medicine. (via Semantic Scholar)
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10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 30, 2019

2019 journal article

Lack of influence by endosymbiont Wolbachia on virus titer in the common bed bug, Cimex lectularius

Parasites & Vectors, 12(1).

By: M. Fisher n, J. Levine n , J. Guy n , H. Mochizuki n , M. Breen n , C. Schal n , D. Watson  n

author keywords: Cimex lectularius; Wolbachia; Endosymbiont; Cimicidae; Virus suppression; ssRNA
MeSH headings : Animals; Bedbugs / microbiology; Bedbugs / virology; Calicivirus, Feline / growth & development; Calicivirus, Feline / isolation & purification; Microbial Interactions; Viral Load; Wolbachia / growth & development
TL;DR: It is suggested that other mechanisms are involved in virus suppression within bed bugs, independent of the influence of Wolbachia, and the need for future research is underscore. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 30, 2019

2019 journal article

Novel Noninvasive Diagnostics

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 49(5), 781-+.

By: C. Wiley n, C. Wise n & M. Breen n 

author keywords: Canine; Cancer; Liquid biopsy; Bladder; Prostate; BRAF; Lymphoma
MeSH headings : Animals; Carcinoma, Transitional Cell / diagnosis; Carcinoma, Transitional Cell / genetics; Carcinoma, Transitional Cell / veterinary; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / genetics; Dogs; Early Detection of Cancer / methods; Early Detection of Cancer / veterinary; Female; Humans; Leukemia / diagnosis; Leukemia / veterinary; Liquid Biopsy / methods; Liquid Biopsy / veterinary; Lymphoma / diagnosis; Lymphoma / drug therapy; Lymphoma / veterinary; Male; Molecular Targeted Therapy / veterinary; Mutation; Neoplasms / diagnosis; Neoplasms / drug therapy; Neoplasms / genetics; Neoplasms / veterinary; Urethral Neoplasms / diagnosis; Urethral Neoplasms / genetics; Urethral Neoplasms / veterinary; Urinary Bladder Neoplasms / veterinary
TL;DR: Noninvasive/minimally invasive techniques have been described in veterinary medicine that could be referred to as liquid biopsy, which offer new opportunities for improving cancer screening, diagnosis, and monitoring the impact of therapy on the patients over time. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 16, 2019

2018 journal article

A comprehensive genomic history of extinct and living elephants

Proceedings of the National Academy of Sciences, 115(11), E2566–E2574.

By: E. Palkopoulou *, M. Lipson *, S. Mallick *, S. Nielsen*, N. Rohland *, S. Baleka *, E. Karpinski *, A. Ivancevic * ...

Contributors: E. Palkopoulou *, M. Lipson *, S. Mallick *, S. Nielsen*, N. Rohland *, S. Baleka *, E. Karpinski *, A. Ivancevic * ...

author keywords: paleogenomics; elephantid evolution; mammoth; admixture; species divergence
MeSH headings : Animals; Elephants / classification; Elephants / genetics; Evolution, Molecular; Extinction, Biological; Fossils; Gene Flow; Genome; Genomics / history; History, Ancient; Mammoths / classification; Mammoths / genetics; Mastodons / classification; Mastodons / genetics; Phylogeny
TL;DR: It is shown that interspecies hybridization has been a recurrent feature of elephantid evolution, and the genetic makeup of the straight-tusked elephant, previously placed as a sister group to African forest elephants based on lower coverage data, in fact comprises three major components. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 21, 2020

2018 journal article

Blood Lead Toxicity Analysis of Multipurpose Canines and Military Working Dogs

Journal of Special Operations Medicine : a Peer Reviewed Journal for SOF Medical Professionals, 18(1), 74–76. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046511406&partnerID=MN8TOARS

By: P. Reid, C. George, C. Byrd, L. Miller, S. Lee, A. Motsinger-Reif, M. Breen , D. Hayduk

Contributors: P. Reid, C. George, C. Byrd, L. Miller, S. Lee, A. Motsinger-Reif, M. Breen , D. Hayduk

www.scopus.com
Source: ORCID
Added: September 22, 2024

2018 article

Comparative genomic analyses of osteosarcoma etiology reveal a chromosomal structural rationale for the increased incidence of osteosarcoma in dogs

Sarver, A. L., Mills, L., Temiz, N., Scott, M. I., Sarver, A., Spector, L., … Largaespada, D. (2018, July). CANCER RESEARCH, Vol. 78.

By: A. Sarver *, L. Mills *, N. Temiz *, M. Scott *, A. Sarver*, L. Spector *, J. Wang*, M. Breen  n ...

TL;DR: It is hypothesized that increased osteosarcoma incidence in dogs is partly due to a syntenic rearrangement of the peri-PTEN locus in the canine genome, which creates a high risk of loss in the context of cytogenetic instability caused by disruption of TP53, thereby providing a structural genetic rational for the higher incidence of osteosARcoma in dogs. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 24, 2019

2018 journal article

Growth kinetics of endosymbiont Wolbachia in the common bed bug, Cimex lectularius

Scientific Reports, 8(1).

By: M. Fisher  n, D. Watson n, J. Osborne n, H. Mochizuki  n, M. Breen n  & C. Schal n 

Contributors: M. Fisher  n, D. Watson n, J. Osborne n, H. Mochizuki  n, M. Breen n  & C. Schal n 

MeSH headings : Animals; Bedbugs / microbiology; DNA / genetics; Female; Kinetics; Larva / microbiology; Symbiosis; Wolbachia / growth & development
TL;DR: It is highlighted that wCle is dynamic during bed bug development, changing relative to life stage, intermolt stage, and blood-fed status, and the observed quantitative modulation of wCle during the bed bug life cycle and during periods of starvation may explain the disparities in wCle infections reported in field-collected C. lectularius. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: December 30, 2019

2018 article

Mutational and transcriptomic profiling identify distinct angiogenic and inflammatory subtypes of angiosarcoma

Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Wang, C., Elvers, I., … Modiano, J. F. (2018, July). CANCER RESEARCH, Vol. 78.

By: J. Kim *, K. Megquier *, A. Sarver *, R. Thomas n, C. Wang *, I. Elvers *, E. Karlsson *, M. Breen n , K. Lindblad-Toh *, J. Modiano *

Sources: Web Of Science, NC State University Libraries
Added: June 24, 2019

2018 journal article

Relationship Between Sequence Homology, Genome Architecture, and Meiotic Behavior of the Sex Chromosomes in North American Voles

GENETICS, 210(1), 83–97.

By: B. Dumont  n, C. Williams n, B. Ng *, V. Horncastle*, C. Chambers *, L. McGraw n, D. Adams *, T. Mackay n, M. Breen n 

Contributors: B. Dumont  n, C. Williams n, B. Ng *, V. Horncastle*, C. Chambers *, L. McGraw n, D. Adams *, T. Mackay n, M. Breen n 

author keywords: pseudoautosomal region; Microtus heterochromatin; telomeric repeats; meiotic synapsis
MeSH headings : Animals; Arvicolinae / genetics; Chromosome Segregation / genetics; Genomics / methods; Meiosis / genetics; North America; Pseudoautosomal Regions / genetics; Sequence Analysis, DNA / methods; Sequence Homology, Nucleic Acid; Sex Chromosomes / genetics; Telomere / genetics; Telomere-Binding Proteins / genetics; X Chromosome / genetics; Y Chromosome / genetics
TL;DR: Key conditions required to sustain the standard program of X/Y synapsis at meiosis are suggested and an intriguing connection between heterochromatic repeat architecture and noncanonical, asynaptic mechanisms of sex chromosome segregation in voles is revealed. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 19, 2018

2018 journal article

SETD2 is recurrently mutated in whole-exome sequenced canine osteosarcoma

Cancer Research, 78(13), 3421–3431.

By: S. Sakthikumar *, I. Elvers *, J. Kim *, M. Arendt *, R. Thomas  n, J. Turner-Maier *, R. Swofford *, J. Johnson * ...

Contributors: S. Sakthikumar *, I. Elvers *, J. Kim *, M. Arendt *, R. Thomas  n, J. Turner-Maier *, R. Swofford *, J. Johnson * ...

Source: ORCID
Added: September 22, 2024

2018 journal article

Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis

PLOS GENETICS, 14(9).

By: W. Hendricks*, V. Zismann *, K. Sivaprakasam *, C. Legendre*, K. Poorman n, W. Tembe*, N. Perdigones*, J. Kiefer * ...

Contributors: W. Hendricks*, V. Zismann *, K. Sivaprakasam *, C. Legendre*, K. Poorman n, W. Tembe*, N. Perdigones*, J. Kiefer * ...

TL;DR: The genomic landscape of canine melanoma is mapped through multi-platform analysis of 37 tumors and matching constitutional samples and identifies novel predominantly truncating mutations in the putative tumor suppressor gene PTPRJ, which resembles that seen in BRAF wild-type and sun-shielded human melanoma subtypes. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 16, 2018

2017 journal article

Evaluation of gene expression and DNA copy number profiles of adipose tissue-derived stromal cells and consecutive neurosphere-like cells generated from dogs with naturally occurring spinal cord injury

American Journal of Veterinary Research, 78(3), 371–380.

By: J. Lim*, S. Koh*, R. Thomas*, M. Breen*  & N. Olby* 

Contributors: J. Lim*, S. Koh*, R. Thomas*, M. Breen*  & N. Olby Vet

MeSH headings : Adipose Tissue / cytology; Animals; Cells, Cultured; Comparative Genomic Hybridization; Dogs; Female; Gene Dosage / genetics; Gene Expression Profiling; Gene Expression Regulation; Male; Neural Stem Cells / cytology; Neural Stem Cells / pathology; Neurons / cytology; Neurons / pathology; Proteins / genetics; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / veterinary; Stromal Cells / cytology; Stromal Cells / physiology
TL;DR: ADSCs can potentially be a safe and clinically relevant autologous source for canine neural progenitor cells and DNA copy number stability was suggested by the methods used. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Generation of LIF-independent induced pluripotent stem cells from canine fetal fibroblasts

Theriogenology, 92, 75–82.

By: N. Gonçalves, F. Bressan *, K. Roballo, F. Meirelles *, P. Xavier, H. Fukumasu, C. Williams n, M. Breen n  ...

Contributors: N. Gonçalves, F. Bressan *, K. Roballo, F. Meirelles *, P. Xavier, H. Fukumasu, C. Williams n, M. Breen n  ...

author keywords: iPSC; Canine; Stem cells; Pluripotency; Cellular reprogramming
MeSH headings : Animals; Dogs; Fetus / cytology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / physiology; Gene Expression Regulation / physiology; Leukemia Inhibitory Factor / pharmacology; Mice; Mice, Inbred BALB C; Mice, Nude; Pluripotent Stem Cells / physiology; Polymerase Chain Reaction / veterinary
TL;DR: This report is the first to describe the ability to reprogram canine somatic cells via lentiviral vectors without supplementation and with resistance to enzymatic action, thereby demonstrating the pluripotency of these cell lines. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Genomic profiling of canine mast cell tumors identifies DNA copy number aberrations associated with KIT mutations and high histological grade

CHROMOSOME RESEARCH, 25(2), 129–143.

By: H. Mochizuki n , R. Thomas n, S. Moroff* & M. Breen n 

Contributors: H. Mochizuki n , R. Thomas n, S. Moroff* & M. Breen n 

author keywords: Cancer; Comparative genomic hybridization; Digital PCR; Dog; Mastocytosis; Pug
MeSH headings : Animals; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dogs; Genome / genetics; Mastocytosis, Cutaneous / diagnosis; Mastocytosis, Cutaneous / genetics; Mastocytosis, Cutaneous / pathology; Mutation; Predictive Value of Tests; Proto-Oncogene Proteins c-kit / genetics; Sensitivity and Specificity
TL;DR: Characterization of genomic alterations in canine MCTs may identify genomic regions and/or genes responsible for their development and progression, facilitating the discovery of new therapeutic targets and improved clinical management of this heterogeneous cancer. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy

Journal of Cellular and Molecular Medicine, 21(8), 1503–1512.

By: M. Hensley n, J. Tang n, K. Woodruff n, T. Defrancesco n , S. Tou n, C. Williams n, M. Breen  n, K. Meurs n  ...

Contributors: M. Hensley n, J. Tang n, K. Woodruff n, T. Defrancesco n , S. Tou n, C. Williams n, M. Breen n , K. Meurs n , B. Keene  n, K. Cheng n

author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy; allogeneic
MeSH headings : Animals; Biomarkers / metabolism; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / immunology; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / therapy; Coronary Vessels / cytology; Coronary Vessels / immunology; Dogs; Echocardiography; Endoglin / genetics; Endoglin / immunology; Female; Gene Expression; Humans; Male; Myocardium / immunology; Myocardium / pathology; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / immunology; Spheroids, Cellular / cytology; Spheroids, Cellular / immunology; Spheroids, Cellular / transplantation; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / immunology; Thy-1 Antigens / genetics; Thy-1 Antigens / immunology; Transplantation, Homologous
TL;DR: The safety and efficacy of allogeneic CDC in a large animal (canine) model of spontaneous DCM and Histology on dog hearts revealed no sign of immune rejection from the transplanted cells. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Malignant canine mammary tumours: Preliminary genomic insights using oligonucleotide array comparative genomic hybridisation analysis

VETERINARY JOURNAL, 222, 68–71.

By: M. Santos *, P. Dias-Pereira *, C. Williams n, C. Lopes * & M. Breen n 

Contributors: M. Santos *, P. Dias-Pereira *, C. Williams n, C. Lopes * & M. Breen n 

author keywords: Array comparative genomic hybridisation; Canine mammary tumours; Chromosome; Genetics
MeSH headings : Animals; Comparative Genomic Hybridization / veterinary; DNA Copy Number Variations; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Mammary Neoplasms, Animal / genetics; Mammary Neoplasms, Animal / pathology
TL;DR: High resolution oligonucleotide array comparative genomic hybridisation was performed to assess genome wide DNA copy number changes in 10 malignant canine mammary tumours from seven female dogs, including multiple tumours collected at one time from each of three female dogs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Safe and effective sarcoma therapy through bispecific targeting of EGFR and uPAR

Molecular Cancer Therapeutics, 16(5), 956–965.

By: A. Borgatti *, J. Koopmeiners *, A. Sarver *, A. Winter, K. Stuebner, D. Todhunter*, A. Rizzardi*, J. Henriksen* ...

Contributors: A. Borgatti *, J. Koopmeiners *, A. Sarver *, A. Winter, K. Stuebner, D. Todhunter*, A. Rizzardi*, J. Henriksen* ...

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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 22, 2024

2016 journal article

Association of breed and histopathological grade in canine mast cell tumours

VETERINARY AND COMPARATIVE ONCOLOGY, 15(3), 829–839.

By: H. Mochizuki n , A. Motsinger-Reif n, C. Bettini, S. Moroff & M. Breen n 

Contributors: H. Mochizuki n , A. Motsinger-Reif n, C. Bettini, S. Moroff & M. Breen n 

author keywords: Boxer; dog; epidemiology; genetics; MCT; Pug
MeSH headings : Age Factors; Animals; Dog Diseases / etiology; Dog Diseases / pathology; Dogs; Female; Male; Mastocytosis, Cutaneous / etiology; Mastocytosis, Cutaneous / pathology; Mastocytosis, Cutaneous / veterinary; Retrospective Studies; Risk Factors; Sex Factors; Skin Neoplasms / etiology; Skin Neoplasms / pathology; Skin Neoplasms / veterinary; Species Specificity
TL;DR: The data indicate that the proportion of high-grade tumours increases with advancing age, and that male and intact dogs have increased odds of developing high- grade tumours, and a genetic association for the development ofhigh-grade MCTs is suggested. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Canine histiocytic malignancies-Challenges and opportunities

Veterinary Sciences, 3(1).

By: K. Kennedy n, R. Thomas  n & M. Breen n 

Contributors: K. Kennedy n, R. Thomas  n & M. Breen n 

Source: ORCID
Added: September 22, 2024

2016 journal article

Comprehensive genomic characterization of five canine lymphoid tumor cell lines

BMC Veterinary Research, 12(1).

By: S. Roode n, D. Rotroff n, K. Richards *, P. Moore*, A. Motsinger-Reif n, Y. Okamura*, T. Mizuno *, H. Tsujimoto *, S. Suter n, M. Breen n 

Contributors: S. Roode n, D. Rotroff n, K. Richards *, P. Moore*, A. Motsinger-Reif n, Y. Okamura*, T. Mizuno *, H. Tsujimoto *, S. Suter n, M. Breen n 

UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2016 journal article

Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies

LEUKEMIA & LYMPHOMA, 58(7), 1702–1710.

By: D. Seelig *, D. Ito *, C. Forster *, U. Yoon *, M. Breen n , L. Burns *, V. Bachanova *, K. Lindblad-Toh * ...

Contributors: D. Seelig *, D. Ito *, C. Forster *, U. Yoon *, M. Breen n , L. Burns *, V. Bachanova *, K. Lindblad-Toh * ...

author keywords: Diffuse large B-cell lymphoma; alternative NF-kappa B pathway; canine model; targeting therapy; comparative pathology
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Cell Line, Tumor; Cell Survival / drug effects; Disease Models, Animal; Dogs; Gene Expression; Genes, Reporter; Humans; Lymphoma, Large B-Cell, Diffuse / drug therapy; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Molecular Targeted Therapy; NF-kappa B / metabolism; Signal Transduction / drug effects
TL;DR: It is demonstrated that dogs with spontaneous DLBCL can provide a useful large animal model to study therapies targeting the ANFκBP and that a small interfering RNA inhibits the activation of the NFκB pathway and induces apoptosis in canineDLBCL cells. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Creation of an NCI comparative brain tumor consortium: Informing the translation of new knowledge from canine to human brain tumor patients

Neuro-Oncology, 18(9), 1209–1218.

By: A. Leblanc *, C. Mazcko*, D. Brown*, J. Koehler *, A. Miller *, C. Miller *, R. Bentley *, R. Packer * ...

Contributors: A. Leblanc *, C. Mazcko*, D. Brown*, J. Koehler *, A. Miller *, C. Miller *, R. Bentley *, R. Packer * ...

Source: ORCID
Added: September 22, 2024

2016 journal article

Integrated immunohistochemical and DNA copy number profiling analysis provides insight into the molecular pathogenesis of canine follicular lymphoma

VETERINARY AND COMPARATIVE ONCOLOGY, 15(3), 852–867.

By: R. Thomas n, Z. Demeter*, K. Kennedy n, L. Borst n , K. Singh *, V. Valli, K. Le Boedec *, M. Breen n 

Contributors: R. Thomas n, Z. Demeter*, K. Kennedy n, L. Borst n , K. Singh *, V. Valli, K. Le Boedec *, M. Breen n 

author keywords: BCL2; canine; comparative genomic hybridization; fluorescence in situ hybridization; follicular lymphoma; immunohistochemistry
MeSH headings : Animals; DNA Copy Number Variations / genetics; DNA Fingerprinting / veterinary; Dog Diseases / etiology; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Genome-Wide Association Study / veterinary; Lymphoma, Follicular / etiology; Lymphoma, Follicular / genetics; Lymphoma, Follicular / pathology; Lymphoma, Follicular / veterinary; Male; Risk Factors
TL;DR: Parallel exploration of canine and human cases may reveal alternative tumour-initiating mechanisms other than BCL2 disruption, yielding a more complete definition of the molecular pathogenesis of FL. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Perspectives from man's best friend: National academy of medicine's workshop on comparative oncology

Science Translational Medicine, 8(324).

By: A. Leblanc *, M. Breen n , P. Choyke *, M. Dewhirst *, T. Fan *, D. Gustafson *, L. Helman *, M. Kastan * ...

Contributors: A. Leblanc *, M. Breen n , P. Choyke *, M. Dewhirst *, T. Fan *, D. Gustafson *, L. Helman *, M. Kastan * ...

Source: ORCID
Added: September 22, 2024

2016 journal article

Sequence analysis of RAS and RAF mutation hot spots in canine carcinoma

VETERINARY AND COMPARATIVE ONCOLOGY, 15(4), 1598–1605.

By: H. Mochizuki n  & M. Breen n 

Contributors: H. Mochizuki n  & M. Breen n 

author keywords: bladder; cancer; dog; prostate; squamous cell carcinoma; transitional cell carcinoma
MeSH headings : Animals; Dog Diseases / genetics; Dogs; Genes, ras / genetics; Mutation / genetics; Neoplasms / genetics; Neoplasms / veterinary; Proto-Oncogene Proteins B-raf / genetics; Sequence Analysis, DNA / veterinary
TL;DR: Evaluated the mutational status of three RAS genes (HRAS, KRAS and NRAS) in four types of canine carcinoma with and without the BRAF V595E mutation, indicating similar functional consequence of these mutations (e.g. MAPK pathway activation). (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

A novel canine kidney cell line model for the evaluation of neoplastic development: karyotype evolution associated with spontaneous immortalization and tumorigenicity

CHROMOSOME RESEARCH, 23(4), 663–680.

By: R. Omeir*, R. Thomas n, B. Teferedegne*, C. Williams n, G. Foseh*, J. Macauley*, L. Brinster*, J. Beren* ...

Contributors: R. Omeir*, R. Thomas n, B. Teferedegne*, C. Williams n, G. Foseh*, J. Macauley*, L. Brinster*, J. Beren* ...

author keywords: Neoplastic transformation; Tumorigenicity; Canine chromosomes; Comparative genomic hybridization (CGH); Fluorescence in situ hybridization (FISH); Madin-Darby canine kidney (MDCK) cell line; CKB1-3T7 cell line
MeSH headings : Animals; Cell Line; Cell Line, Transformed; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic / genetics; Cells, Cultured; Chromosome Aberrations; DNA Copy Number Variations; Dogs; In Situ Hybridization, Fluorescence; Karyotype; Madin Darby Canine Kidney Cells; Male; Neoplasms / genetics; Neoplasms / pathology
TL;DR: Through integrated cytogenomic and phenotypic characterization of serial passages of CKB1-3T7 from initiation to development of a tumorigenic phenotype, this work presents a robust and readily accessible model of spontaneous neoplastic transformation that overcomes many of the limitations of earlier studies. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

BRAF Mutations in Canine Cancers

PLOS ONE, 10(6).

By: H. Mochizuki n , K. Kennedy n, S. Shapiro n & M. Breen n 

Contributors: H. Mochizuki n , K. Kennedy n, S. Shapiro n & M. Breen n 

MeSH headings : Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Dogs; Exons / genetics; Female; Genetic Predisposition to Disease; Humans; Male; Molecular Sequence Data; Mutation / genetics; Neoplasms / genetics; Neoplasms / veterinary; Proto-Oncogene Proteins B-raf / chemistry; Proto-Oncogene Proteins B-raf / genetics; Sequence Analysis, DNA
TL;DR: The evolutional conservation of the BRAF V600E mutation highlights the importance of MAPK pathway activation in neoplasia and may offer opportunity for molecular diagnostics and targeted therapeutics for dogs bearing BRAF-mutated cancers. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Canine urothelial carcinoma: genomically aberrant and comparatively relevant

Chromosome Research, 23(2), 311–331.

By: S. Shapiro n, S. Raghunath n, C. Williams n, A. Motsinger-Reif n, J. Cullen n, T. Liu*, D. Albertson*, M. Ruvolo* ...

Contributors: S. Shapiro n, S. Raghunath n, C. Williams n, A. Motsinger-Reif n, J. Cullen n, T. Liu*, D. Albertson*, M. Ruvolo* ...

author keywords: Canine; Urothelial carcinoma; Transitional cell carcinoma; Cytogenetics; Chromosome aberration; Array comparative genomic hybridization; Comparative oncology
MeSH headings : Animals; Biopsy; Carcinoma / veterinary; Chromosome Aberrations; Comparative Genomic Hybridization; Computational Biology / methods; DNA Copy Number Variations; Dogs; Female; Genetic Loci; Genomics / methods; Humans; In Situ Hybridization, Fluorescence; Male; Urologic Neoplasms / veterinary
TL;DR: It is proposed that common aberrations found in primary canine UC biopsies are indicative of an evolutionarily conserved mechanism of pathogenesis and harbor genes key to urothelial neoplasia, warranting investigation for diagnostic, prognostic, and therapeutic applications. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2015 journal article

Comparative aspects of BRAF mutations in canine cancers

Veterinary Sciences, 2(3), 231–245.

By: H. Mochizuki  n & M. Breen n 

Contributors: H. Mochizuki  n & M. Breen n 

Source: ORCID
Added: September 22, 2024

2015 review

Comparative oncology: what dogs and other species can teach us about humans with cancer

By: J. Schiffman * & M. Breen n 

Contributors: J. Schiffman * & M. Breen n 

author keywords: comparative oncology; genomics; genetics; cancer; canine; human
MeSH headings : Animals; Breeding; Disease Models, Animal; Dog Diseases / etiology; Dogs; Female; Genome-Wide Association Study / veterinary; Genomics; Germ-Line Mutation; Humans; Male; Neoplasms / etiology; Neoplasms / veterinary; Risk Factors; Species Specificity; Translational Research, Biomedical
TL;DR: This review begins with the genetic origins of canines and their advantage in cancer research, and next focuses on recent findings in comparative oncology related to inherited, or genetic, risk for tumour development. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Detection of BRAF Mutation in Urine DNA as a Molecular Diagnostic for Canine Urothelial and Prostatic Carcinoma

PLOS ONE, 10(12).

By: H. Mochizuki n , S. Shapiro n & M. Breen n 

Contributors: H. Mochizuki n , S. Shapiro n & M. Breen n 

MeSH headings : Animals; Biomarkers, Tumor / urine; DNA / urine; Dogs; Male; Mutation; Polymerase Chain Reaction; Prostatic Neoplasms / diagnosis; Prostatic Neoplasms / urine; Proto-Oncogene Proteins B-raf / genetics; Urinary Bladder Neoplasms / diagnosis; Urinary Bladder Neoplasms / urine
TL;DR: It is shown that ddPCR is a sensitive molecular technique with the potential to facilitate accurate and non-invasive means of canine UC and PC diagnosis. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Detection of Copy Number Imbalance in Canine Urothelial Carcinoma With Droplet Digital Polymerase Chain Reaction

VETERINARY PATHOLOGY, 53(4), 764–772.

By: H. Mochizuki n , S. Shapiro n, M. Breen n  & V. pathology

Contributors: H. Mochizuki n , S. Shapiro n & M. Breen n 

author keywords: comparative genomic hybridization; cytogenetics; dogs; molecular diagnostic; transitional cell carcinoma; polymerase chain reaction; urinary bladder; urothelial carcinoma
MeSH headings : Animals; Carcinoma, Transitional Cell / diagnosis; Carcinoma, Transitional Cell / genetics; Carcinoma, Transitional Cell / pathology; Carcinoma, Transitional Cell / veterinary; Comparative Genomic Hybridization / veterinary; DNA Copy Number Variations; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Polymerase Chain Reaction / veterinary; Urinary Bladder / pathology; Urinary Bladder Neoplasms / diagnosis; Urinary Bladder Neoplasms / genetics; Urinary Bladder Neoplasms / pathology; Urinary Bladder Neoplasms / veterinary; Urologic Neoplasms / diagnosis; Urologic Neoplasms / genetics; Urologic Neoplasms / pathology; Urologic Neoplasms / veterinary
TL;DR: The findings show that ddPCR is a useful molecular technique to detect CNAs and may be used as a noninvasive molecular diagnostic test for canine UC. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background

Genome Research, 25(11), 1634–1645.

By: I. Elvers *, J. Turner-Maier *, R. Swofford *, M. Koltookian*, J. Johnson *, C. Stewart *, C. Zhang *, S. Schumacher * ...

Contributors: I. Elvers *, J. Turner-Maier *, R. Swofford *, M. Koltookian*, J. Johnson *, C. Stewart *, C. Zhang *, S. Schumacher * ...

Source: ORCID
Added: September 22, 2024

2015 journal article

Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers

PLoS Genetics, 11(2), 1–24.

By: N. Tonomura*, I. Elvers *, R. Thomas  n, K. Megquier *, J. Turner-Maier *, C. Howald*, A. Sarver *, R. Swofford * ...

Contributors: N. Tonomura*, I. Elvers *, R. Thomas  n, K. Megquier *, J. Turner-Maier *, C. Howald*, A. Sarver *, R. Swofford * ...

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3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 22, 2024

2015 journal article

Genome-wide assessment of recurrent genomic imbalances in canine leukemia identifies evolutionarily conserved regions for subtype differentiation

Chromosome Research, 23(4), 681–708.

By: S. Roode n, D. Rotroff n, A. Avery *, S. Suter n, D. Bienzle *, J. Schiffman *, A. Motsinger-Reif n, M. Breen n 

Contributors: S. Roode n, D. Rotroff n, A. Avery *, S. Suter n, D. Bienzle *, J. Schiffman *, A. Motsinger-Reif n, M. Breen n 

author keywords: Leukemia; Canine; Chromosome; Comparative genomic hybridization; Comparative genomics
MeSH headings : Algorithms; Animals; Cell Transformation, Neoplastic / genetics; Chromosome Aberrations; Chromosome Mapping; Cluster Analysis; Comparative Genomic Hybridization; Conserved Sequence; DNA Copy Number Variations; Disease Models, Animal; Dogs; Evolution, Molecular; Female; Gene Dosage; Genome-Wide Association Study; Genomic Library; Genomics; Humans; In Situ Hybridization, Fluorescence; Leukemia / diagnosis; Leukemia / genetics; Leukemia / metabolism; Male
TL;DR: The use of canine leukemia as a relevant in vivo model for human leukemia is supported and the need to further explore the conserved genomic regions of interest for their clinical impact is justified. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2015 journal article

Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma

VETERINARY AND COMPARATIVE ONCOLOGY, 15(2), 315–327.

By: K. Im*, A. Graef*, M. Breen n , K. Lindblad-Toh *, J. Modiano * & J. Kim *

Contributors: K. Im*, A. Graef*, M. Breen n , K. Lindblad-Toh *, J. Modiano * & J. Kim *

author keywords: canine hemangiosarcoma; CXCR4; CXCL12; invasion; migration
MeSH headings : Animals; Cell Line, Tumor; Cell Movement / physiology; Chemokine CXCL12 / physiology; Dog Diseases / pathology; Dogs; Flow Cytometry / veterinary; Gene Expression Profiling / veterinary; Gene Expression Regulation, Neoplastic / physiology; Hemangiosarcoma / pathology; Hemangiosarcoma / veterinary; Neoplasm Invasiveness / pathology; Receptors, CXCR4 / physiology
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 article

Peto's paradox and the promise of comparative oncology

Nunney, L., Maley, C. C., Breen, M., Hochberg, M. E., & Schiffman, J. D. (2015, July 19). PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol. 370.

By: L. Nunney *, C. Maley*, M. Breen n , M. Hochberg * & J. Schiffman *

Contributors: L. Nunney *, C. Maley*, M. Breen n , M. Hochberg * & J. Schiffman *

author keywords: Peto's paradox; comparative oncology; evolution; life-history theory; cancer; modelling
MeSH headings : Animals; Biological Evolution; Body Size; Cocarcinogenesis; Female; Humans; Longevity; Male; Mammals; Models, Biological; Neoplasms / etiology
TL;DR: The history of the field is reviewed and how the contributions use empirical, comparative and theoretical approaches to address the processes and patterns associated with ‘Peto's paradox’, the lack of a statistical relationship of cancer incidence with body size and longevity is outlined. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Canine Prostate Cancer Cell Line (Probasco) Produces Osteoblastic Metastases In Vivo

PROSTATE, 74(13), 1251–1265.

By: J. Simmons*, W. Dirksen *, B. Hildreth *, C. Dorr n, C. Williams n, R. Thomas n, M. Breen n , R. Toribio *, T. Rosol *

Contributors: J. Simmons*, W. Dirksen *, B. Hildreth *, C. Dorr n, C. Williams n, R. Thomas n, M. Breen n , R. Toribio *, T. Rosol *

author keywords: prostate cancer; osteoblastic metastases; canine; dog
MeSH headings : Animals; Biomarkers, Tumor / genetics; Biomarkers, Tumor / metabolism; Bone Neoplasms / genetics; Bone Neoplasms / metabolism; Bone Neoplasms / secondary; Carcinoma / genetics; Carcinoma / metabolism; Carcinoma / secondary; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dogs; Male; Mice; Mice, Nude; Neoplasm Transplantation; Osteoblasts / metabolism; Osteoblasts / pathology; Prostatic Neoplasms / genetics; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology
TL;DR: This study established and characterized a novel canine prostate cancer cell line that will contribute to the understanding of prostate cancer pathogenesis. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Comparative cytogenetic characterization of primary canine melanocytic lesions using array CGH and fluorescence in situ hybridization

CHROMOSOME RESEARCH, 23(2), 171–186.

By: K. Poorman n, L. Borst n , S. Moroff*, S. Roy n, P. Labelle*, A. Motsinger-Reif n, M. Breen n 

Contributors: K. Poorman n, L. Borst n , S. Moroff*, S. Roy n, P. Labelle*, A. Motsinger-Reif n, M. Breen n 

author keywords: Canine; Oral melanoma; Cytogenetics; Array; Comparative genomic hybridization
MeSH headings : Animals; Chromosome Aberrations; Cluster Analysis; Comparative Genomic Hybridization; Computational Biology; DNA Copy Number Variations; Dogs; Female; Humans; In Situ Hybridization, Fluorescence; Male; Melanoma / genetics; Melanoma / metabolism; Melanoma / pathology; Mouth Neoplasms / genetics; Mouth Neoplasms / pathology; Penetrance; Skin Neoplasms
TL;DR: This study suggests that in concordance with what is known for human melanomas, canine melanomas of the oral mucosa and cutaneous epithelium are discrete and initiated by different molecular pathways. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Definition of the Cattle Killer Cell Ig-like Receptor Gene Family: Comparison with Aurochs and Human Counterparts

JOURNAL OF IMMUNOLOGY, 193(12), 6016–6030.

By: N. Sanderson *, P. Norman *, L. Guethlein *, S. Ellis*, C. Williams n, M. Breen n , S. Park*, D. Magee* ...

Contributors: N. Sanderson *, P. Norman *, L. Guethlein *, S. Ellis*, C. Williams n, M. Breen n , S. Park*, D. Magee* ...

MeSH headings : Animals; Cattle; Chromosome Mapping; Chromosomes, Mammalian; Cloning, Molecular; Evolution, Molecular; Gene Library; Genetic Loci; Genome; Haplotypes; Humans; Immunoglobulins / genetics; Molecular Sequence Data; Multigene Family; Phenotype; Phylogeny; Receptors, IgG / metabolism; Receptors, KIR / classification; Receptors, KIR / genetics; Receptors, KIR / metabolism; Receptors, Natural Killer Cell / metabolism; Sequence Analysis, DNA; Signal Transduction; Telomere
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

CHROMOSOME RESEARCH, 22(3), 305–319.

By: R. Thomas n, L. Borst n , D. Rotroff n, A. Motsinger-Reif n, K. Lindblad-Toh *, J. Modiano *, M. Breen n 

Contributors: R. Thomas n, L. Borst n , D. Rotroff n, A. Motsinger-Reif n, K. Lindblad-Toh *, J. Modiano *, M. Breen n 

author keywords: canine; chromosome; hemangiosarcoma; comparative genomic hybridization (CGH)
MeSH headings : Animals; Breeding; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dog Diseases / genetics; Dogs; Gene Amplification; Gene Expression Profiling; Genetic Heterogeneity; Genome; Hemangiosarcoma / genetics; Hemangiosarcoma / veterinary; Penetrance; Vascular Endothelial Growth Factor A / genetics
TL;DR: Analysis of genome-wide microarray-based somatic DNA copy number profiling of 75 primary intra-abdominal hemangiosarcomas from five popular dog breeds supports prior transcriptional studies suggesting that the clinical heterogeneity of this cancer may reflect the existence of multiple, molecularly distinct subtypes of canine hemangiusarcoma. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Identification of Three Molecular and Functional Subtypes in Canine Hemangiosarcoma through Gene Expression Profiling and Progenitor Cell Characterization

AMERICAN JOURNAL OF PATHOLOGY, 184(4), 985–995.

By: B. Gorden*, J. Kim *, A. Sarver *, A. Frantz *, M. Breen n , K. Lindblad-Toh *, . Timothy D. O'Brien *, L. Sharkey *, J. Modiano *, E. Dickerson *

Contributors: B. Gorden*, J. Kim *, A. Sarver *, A. Frantz *, M. Breen n , K. Lindblad-Toh *, . T.D. O'Brien, L. Sharkey *, J. Modiano *, E. Dickerson *

MeSH headings : Animals; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Gene Expression Profiling; Hemangiosarcoma / genetics; Hemangiosarcoma / pathology; Hemangiosarcoma / veterinary; Immunophenotyping; Neoplastic Stem Cells / pathology; Oligonucleotide Array Sequence Analysis
TL;DR: Improved understanding of the mechanisms that determine the molecular and phenotypic differentiation of tumor cells in vivo could change paradigms regarding the origin and progression of endothelial sarcomas. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Three crocodilian genomes reveal ancestral patterns of evolution among archosaurs

By: R. Green *, E. Braun *, J. Armstrong *, D. Earl*, N. Nguyen*, G. Hickey *, M. Vandewege *, J. St John* ...

Contributors: R. Green *, E. Braun *, J. Armstrong *, D. Earl*, N. Nguyen*, G. Hickey *, M. Vandewege *, J. St John* ...

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UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: ORCID
Added: September 22, 2024

2013 journal article

Gene Profiling of Canine B-Cell Lymphoma Reveals Germinal Center and Postgerminal Center Subtypes with Different Survival Times, Modeling Human DLBCL

Cancer Research, 73(16), 5029–5039.

By: K. Richards  n, A. Motsinger-Reif n, H. Chen  n, Y. Fedoriw  n, C. Fan  n, D. Nielsen n , G. Small n, R. Thomas  n ...

Contributors: K. Richards  n, A. Motsinger-Reif n, H. Chen  n, Y. Fedoriw  n, C. Fan  n, D. Nielsen n , G. Small n, R. Thomas  n ...

MeSH headings : Adolescent; Animals; Child; Child, Preschool; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Disease Models, Animal; Dogs; Female; Gene Expression Profiling / methods; Germinal Center / metabolism; Germinal Center / pathology; Humans; Immunoglobulin Heavy Chains / genetics; Immunoglobulin Heavy Chains / metabolism; Interferon Regulatory Factors / genetics; Interferon Regulatory Factors / metabolism; Lymph Nodes / metabolism; Lymph Nodes / pathology; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / metabolism; Lymphoma, B-Cell / pathology; Lymphoma, Large B-Cell, Diffuse / genetics; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Male; Mutation; NF-kappa B / genetics; NF-kappa B / metabolism; Proto-Oncogene Proteins c-bcl-6; Transcriptome
TL;DR: These studies identify molecular similarities to h DLBCL that introduce pet dogs as a representative model of hDLBCL for future studies, including therapeutic clinical trials. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2013 journal article

Gene selection and cancer type classification of diffuse large-B-cell lymphoma using a bivariate mixture model for two-species data

Human Genomics, 7(1).

By: Y. Su*, D. Nielsen n , L. Zhu *, K. Richards *, S. Suter n, M. Breen n , A. Motsinger-Reif n, J. Osborne n

Contributors: Y. Su*, D. Nielsen n , L. Zhu *, K. Richards *, S. Suter n, M. Breen n , A. Motsinger-Reif n, J. Osborne n

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UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2013 journal article

Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

Genome Biology, 14(12).

By: E. Karlsson *, S. Sigurdsson *, E. Ivansson *, R. Thomas  n, I. Elvers *, J. Wright *, C. Howald*, N. Tonomura* ...

Contributors: E. Karlsson *, S. Sigurdsson *, E. Ivansson *, R. Thomas  n, I. Elvers *, J. Wright *, C. Howald*, N. Tonomura* ...

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3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 22, 2024

2013 journal article

Molecular characterization of canine BCR-ABL-positive chronic myelomonocytic leukemia before and after chemotherapy

Veterinary Clinical Pathology, 42(3), 314–322.

By: S. Culver n, D. Ito *, L. Borst n , J. Bell*, J. Modiano * & M. Breen n 

Contributors: S. Culver n, D. Ito *, L. Borst n , J. Bell*, J. Modiano * & M. Breen n 

author keywords: Chromosome; cytogenetics; hematopoietic cells; remission; vincristine
MeSH headings : Animals; Chromosomes, Human, Pair 7 / genetics; Comparative Genomic Hybridization / veterinary; Dog Diseases / drug therapy; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Fusion Proteins, bcr-abl / genetics; Humans; In Situ Hybridization, Fluorescence / veterinary; Leukemia, Myelomonocytic, Chronic / drug therapy; Leukemia, Myelomonocytic, Chronic / genetics; Leukemia, Myelomonocytic, Chronic / pathology; Leukemia, Myelomonocytic, Chronic / veterinary; Male; Trisomy / genetics
TL;DR: Cytology and flow cytometric techniques were used to diagnose chronic myelomonocytic leukemia in a dog and the applicability of cytogenetics techniques to evaluate the cytogenetic response of canine leukemia to chemotherapy was demonstrated. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2013 article

Naturally occuring canine cancers: powerful models for stimulating pharmacogenomic advancement in human medicine

Rotroff, D. M., Thomas, R., Breen, M., & Motsinger-Reif, A. A. (2013, December). PHARMACOGENOMICS, Vol. 14, pp. 1929–1931.

By: D. Rotroff n, R. Thomas n, M. Breen n  & A. Motsinger-Reif n

Contributors: D. Rotroff n, R. Thomas n, M. Breen n  & A. Motsinger-Reif n

author keywords: cancer; canine model; chemotherapy; clinical trials
MeSH headings : Animals; Disease Models, Animal; Dogs; Humans; Neoplasms / drug therapy; Neoplasms / pathology; Pharmacogenetics / methods
TL;DR: Dogs exhibit a wide variety of spontaneous cancers that share extensive clinicopathologic features with those of human patients, offering a unique opportunity for comparative analysis of cancer etiology and pharmacogenomics. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Partial cytogenetic response with toceranib and prednisone treatment in a young dog with chronic monocytic leukemia

ANTI-CANCER DRUGS, 24(10), 1098–1103.

By: M. Perez, S. Culver*, J. Owen*, M. Dunbar*, K. Kow, M. Breen n , R. Milner

Contributors: M. Pérez, S. Culver*, J. Owen*, M. Dunbar*, K. Kow, M. Breen n , R. Milner

author keywords: cytogenetic analysis; fluorescence in-situ hybridization; monocytosis; toceranib; tyrosine kinase inhibitor
MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cell Proliferation / drug effects; Dog Diseases / drug therapy; Dog Diseases / genetics; Dogs; Female; Fusion Proteins, bcr-abl / antagonists & inhibitors; Fusion Proteins, bcr-abl / genetics; In Situ Hybridization, Fluorescence; Indoles / administration & dosage; Indoles / therapeutic use; Leukemia, Myeloid / drug therapy; Leukemia, Myeloid / genetics; Leukemia, Myeloid / pathology; Leukemia, Myeloid / veterinary; Prednisone / administration & dosage; Prednisone / therapeutic use; Pyrroles / administration & dosage; Pyrroles / therapeutic use; Translocation, Genetic; Treatment Outcome
TL;DR: A case of CMoL in a young dog that achieved clinical remission with treatment with the tyrosine kinase inhibitor toceranib and prednisone is reported. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations

Cancer Genetics, 205(11), 572–587.

By: A. Angstadt n, V. Thayanithy*, S. Subramanian *, J. Modiano * & M. Breen n 

Contributors: A. Angstadt n, V. Thayanithy*, S. Subramanian *, J. Modiano * & M. Breen n 

author keywords: Osteosarcoma; oligo-aCGH; canine; comparative oncology
MeSH headings : Adolescent; Adult; Algorithms; Animals; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Child; Chromosome Aberrations; Comparative Genomic Hybridization / methods; DNA Copy Number Variations; Dog Diseases / genetics; Dogs; Female; Genome, Human; Genomics / methods; Humans; Male; Osteosarcoma / genetics; Osteosarcoma / veterinary; Species Specificity
TL;DR: These findings support and build upon the high level of cytogenetic complexity, through the identification of shared regions of microaberration and functional analysis of possible orthologous OS-associated genes to pinpoint the cellular processes most commonly affected by aberration in human and canine OS. (via Semantic Scholar)
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Sources: Crossref, NC State University Libraries, ORCID
Added: August 14, 2021

2012 journal article

Acute myeloblastic leukemia with associated BCR-ABL translocation in a dog

VETERINARY CLINICAL PATHOLOGY, 41(3), 362–368.

By: J. Figueiredo*, S. Culver n, E. Behling-Kelly *, M. Breen n  & K. Friedrichs*

Contributors: J. Figueiredo*, S. Culver n, E. Behling-Kelly *, M. Breen n  & K. Friedrichs*

author keywords: Cytogenetics; FISH; immunophenotyping; Raleigh chromosome
MeSH headings : Animals; Bone Marrow / pathology; Cytogenetic Analysis / veterinary; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Fusion Proteins, bcr-abl / genetics; Hematologic Tests / veterinary; Immunophenotyping / veterinary; In Situ Hybridization, Fluorescence / veterinary; Leukemia, Myeloid, Acute / genetics; Leukemia, Myeloid, Acute / immunology; Leukemia, Myeloid, Acute / pathology; Leukemia, Myeloid, Acute / veterinary; Male; Translocation, Genetic / genetics
TL;DR: This is the first report of AML with a BCR-ABL translocation in a domestic animal and large multinucleated cells were observed frequently, supporting megakaryocytic lineage. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas

Cancer, 118(23), 5878–5887.

By: A. Italiano *, C. Chen *, R. Thomas n, M. Breen n , F. Bonnet*, N. Sevenet *, M. Longy *, R. Maki *, J. Coindre*, C. Antonescu *

Contributors: A. Italiano *, C. Chen *, R. Thomas n, M. Breen n , F. Bonnet*, N. Sevenet *, M. Longy *, R. Maki *, J. Coindre*, C. Antonescu *

author keywords: angiosarcoma; p53; phosphoinositide-3-kinase; catalytic; alpha polypeptide; phosphatase and tensin homolog; complex karyotype
MeSH headings : Adult; Aged; Aged, 80 and over; Class I Phosphatidylinositol 3-Kinases; Female; Genes, p53; Genomics; Hemangiosarcoma / etiology; Hemangiosarcoma / genetics; Humans; Male; Middle Aged; Mutation; PTEN Phosphohydrolase / genetics; Phosphatidylinositol 3-Kinases / physiology; Proto-Oncogene Proteins B-raf / genetics; Proto-Oncogene Proteins c-akt / physiology; Proto-Oncogene Proteins c-mdm2 / analysis; Signal Transduction / physiology; TOR Serine-Threonine Kinases / physiology
TL;DR: The p53 and phosphoinositide‐3‐kinase, catalytic, alpha polypeptide/v‐akt murine thymoma viral oncogene homolog/mechanistic target of rapamycin (PIK3CA/AKT/mTOR) pathways frequently are altered in sarcoma with complex genomics, such as leiomyosarcoma (LMS) or undifferentiated pleomorphic sarcomA (UPS). (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: June 6, 2020

2012 journal article

Array-based comparative genomic hybridization-guided identification of reference genes for normalization of real-time quantitative polymerase chain reaction assay data for lymphomas, histiocytic sarcomas, and osteosarcomas of dogs

AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(9), 1335–1343.

By: P. Tsai n & M. Breen* 

Contributors: P. Tsai n & M. Breen* 

MeSH headings : Animals; Comparative Genomic Hybridization / methods; Comparative Genomic Hybridization / standards; Comparative Genomic Hybridization / veterinary; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Gene Dosage; Histiocytic Sarcoma / genetics; Histiocytic Sarcoma / pathology; Histiocytic Sarcoma / veterinary; Immunohistochemistry; Lymphoma / genetics; Lymphoma / pathology; Lymphoma / veterinary; Osteosarcoma / genetics; Osteosarcoma / pathology; Osteosarcoma / veterinary; RNA, Neoplasm / chemistry; RNA, Neoplasm / genetics; Real-Time Polymerase Chain Reaction / methods; Real-Time Polymerase Chain Reaction / standards; Real-Time Polymerase Chain Reaction / veterinary; Reference Standards
TL;DR: Results of the present study indicated LOC611555 may be a useful RT-qPCR assay reference gene for multiple tissue types, such as lymphomas, osteosarcomas, or histiocytic sarcomas. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies

LEUKEMIA & LYMPHOMA, 53(7), 1390–1398.

By: D. Ito *, A. Frantz *, C. Williams*, R. Thomas n, R. Burnett*, A. Avery *, M. Breen n , N. Mason *, . Timothy D. O'Brien *, J. Modiano *

Contributors: D. Ito *, A. Frantz *, C. Williams*, R. Thomas n, R. Burnett*, A. Avery *, M. Breen n , N. Mason *, . T.D. O'Brien, J. Modiano *

author keywords: Diffuse large B-cell lymphoma; CD40L; primary cell culture; canine model; cytotoxicity assay
MeSH headings : Animals; CD40 Ligand / genetics; CD40 Ligand / metabolism; CD40 Ligand / pharmacology; Cell Culture Techniques / methods; Cell Proliferation / drug effects; Cell Survival / drug effects; Coculture Techniques; Dogs; Dose-Response Relationship, Drug; Feeder Cells / metabolism; Gene Expression Profiling; Humans; Lymphoma, Large B-Cell, Diffuse / genetics; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Oligonucleotide Array Sequence Analysis; Recombinant Proteins / pharmacology; Tumor Cells, Cultured
TL;DR: This work used primary canine diffuse large B-cell lymphoma to establish a culture system that reliably supports the growth of these cells in vitro and illustrates the utility of the feeder cell-free culture system for comparable assessment of cytotoxicity using dog and human B- cell malignancies. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 book

Canine cytogenetics and chromosome maps

In Genetics of the Dog: 2nd Edition (pp. 241–254). http://www.scopus.com/inward/record.url?eid=2-s2.0-84871573360&partnerID=MN8TOARS

By: M. Breen  & R. Thomas

Contributors: M. Breen  & R. Thomas

www.scopus.com
Source: ORCID
Added: September 22, 2024

2012 conference paper

Generation and characterization of induced pluripotent stem cells (iPS) from adult canine fibroblasts

Reproduction in Domestic Animals, 47, 418–419.

By: S. Koh, S. Tsai, S. Bischoff, R. Thomas, J. Lim, M. Breen , N. Olby , J. Piedrahita 

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Growth Requirements and Chromosomal Instability of Induced Pluripotent Stem Cells Generated from Adult Canine Fibroblasts

Stem Cells and Development, 22(6), 951–963.

By: S. Koh n, R. Thomas n, S. Tsai n, S. Bischoff n, J. Lim n, M. Breen n , N. Olby n , J. Piedrahita n 

Contributors: S. Koh n, R. Thomas n, S. Tsai n, S. Bischoff n, J. Lim n, M. Breen n , N. Olby n , J. Piedrahita n 

MeSH headings : Alkaline Phosphatase / metabolism; Animals; Antigens, Differentiation / genetics; Antigens, Differentiation / metabolism; Cell Differentiation; Cell Shape; Cells, Cultured; Chromosomal Instability; Coculture Techniques; Comparative Genomic Hybridization; Dogs; Fibroblasts / physiology; Gene Expression; In Situ Hybridization, Fluorescence; Induced Pluripotent Stem Cells / enzymology; Induced Pluripotent Stem Cells / pathology; Induced Pluripotent Stem Cells / transplantation; Kruppel-Like Factor 4; Mice; Mice, SCID; Recombinant Proteins / biosynthesis; Recombinant Proteins / genetics; Teratoma / genetics; Teratoma / pathology; Transcription Factors / biosynthesis; Transcription Factors / genetics
TL;DR: The isolated ciPSCs have similar characteristics to ESCs from other species, but the exact cellular mechanisms behind their unique co-dependency on both FGF2 and LIF are still unknown. (via Semantic Scholar)
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Added: August 6, 2018

2012 journal article

Molecular profiling reveals prognostically signific