Michael Bagley

Works (11)

Updated: July 16th, 2023 21:13

2022 journal article

Normalization techniques for high-throughput screening by infrared matrix-assisted laser desorption electrospray ionization mass spectrometry

JOURNAL OF MASS SPECTROMETRY, 57(6).

By: K. Knizner n, M. Bagley n, F. Pu *, N. Elsen *, J. Williams * & D. Muddiman n 

author keywords: high-throughput screening; IR-MALDESI; normalization; Orbitrap mass spectrometer
MeSH headings : Drug Discovery; High-Throughput Screening Assays; Lasers; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: Optimal solvent compositions for increasing measured analyte abundances with direct analysis by IR‐MALDESI‐MS are reported and normalization strategies, such as adding a normalization standard that is similar or dissimilar in structure to the model target drug, are evaluated. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022

2022 journal article

Optimized C-Trap Timing of an Orbitrap 240 Mass Spectrometer for High-Throughput Screening and Native MS by IR-MALDESI

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 33(2), 328–334.

By: K. Knizner n, M. Bagley n, K. Garrard  n, J. Hauschild*, F. Pu *, N. Elsen *, J. Williams *, D. Muddiman n 

author keywords: high-throughput screening; IR-MALDESI; Orbitrap mass spectrometer; C-trap
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Sources: Web Of Science, NC State University Libraries
Added: March 7, 2022

2021 journal article

Investigations of beta-carotene radical cation formation in infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI)

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 35(16).

By: M. Bagley  n & D. Muddiman n 

MeSH headings : Cations / analysis; Cations / chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Tandem Mass Spectrometry; beta Carotene / analysis; beta Carotene / chemistry
TL;DR: There are several potential mechanisms for β-carotene radical cationization prior to IR-MALDESI analysis with multiphoton-ionization, thermal degradation, and/or reaction with oxygen, but changing certain aspects of sample conditions can result in significant mixed-mode ionization with competing protonation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 26, 2021

2021 article

The development and application of matrix assisted laser desorption electrospray ionization: The teenage years

Bagley, M. C., Garrard, K. P., & Muddiman, D. C. (2021, May 24). MASS SPECTROMETRY REVIEWS, Vol. 5.

By: M. Bagley n, K. Garrard  n & D. Muddiman n 

author keywords: ambient ionization; direct analysis; FTMS; IR lasers; MALDESI; mass spectrometry imaging; MSiReader
MeSH headings : Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Lasers
TL;DR: This review will discuss the developments of MALDESI since its first laboratory demonstration in 2005 to the most recent advances in 2021. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021

2020 journal article

3D Imaging and metabolomic profiling reveal higher neuroactive kavalactone contents in lateral roots and crown root peels of Piper methysticum (kava)

GIGASCIENCE, 9(9).

By: Y. Jaiswal *, A. Yerke *, M. Bagley  n, M. Ekelof n, D. Weber *, D. Haddad *, A. Fodor *, D. Muddiman n , L. Williams*

author keywords: kava; kavalactones; metabolomics; 3D imaging; mass spectrometry imaging
MeSH headings : Imaging, Three-Dimensional; Kava; Lactones; Metabolomics; X-Ray Microtomography
TL;DR: Detailed metabolomic profile and spatio-temporal characteristics of tissues from the roots and stems are characterized using cross-platform metabolomics and a 3D imaging approach to provide mechanistic insights into the social and clinical practice of the use of only peeled roots. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: November 16, 2020

2020 journal article

A Versatile Platform for Mass Spectrometry Imaging of Arbitrary Spatial Patterns

Journal of the American Society for Mass Spectrometry, 31(12), 2547–2552.

By: K. Garrard n, M. Ekelöf n, S. Khodjaniyazova n, M. Bagley  n & D. Muddiman n 

author keywords: Mass Spectrometry Imaging; Arbitrary Region of Interest; MALDESI; Vision-System
TL;DR: A vision-system driven platform, RastirX, has been constructed for mass spectrometry imaging (MSI) of arbitrary two-dimensional patterns that reduces contamination from off-sample material and significantly reduces acquisition time. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: January 19, 2021

2020 journal article

Determination of Optimal Electrospray Parameters for Lipidomics in Infrared-Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry Imaging

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 31(2), 319–325.

By: M. Bagley  n, M. Ekelof n & D. Muddiman n 

author keywords: IR-MALDESI; mass spectrometry imaging: electrospray ionization; metabolites; lipids
MeSH headings : Animals; Lipidomics / methods; Lipids / analysis; Liver / chemistry; Liver / diagnostic imaging; Molecular Imaging / methods; Rats; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: Using these defined parameters, IR-MALDESI positive polarity lipidomics studies can increase lipid abundances 3-fold, with 15% greater coverage, while an abundance increase of 1.5-fold and 10% more coverage can be achieved relative to commonly used parameters in negative polarity. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: March 10, 2020

2020 journal article

Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging analysis of endogenous metabolites in cherry tomatoes

ANALYST, 145(16), 5516–5523.

By: M. Bagley, C. Pace*, M. Ekelof* & D. Muddiman n 

MeSH headings : Lasers; Lipids; Solanum lycopersicum; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
TL;DR: The spatially resolved metabolic profiling of cherry tomatoes using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI), a mass spectrometry imaging technique that operates at ambient conditions and requires no sample derivatization, finds endogenous carotenoid hydrocarbons ionized as radical cations. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 31, 2020

2019 journal article

Development of a relative quantification method for infrared matrix‐assisted laser desorption electrospray ionization mass spectrometry imaging of <i>Arabidopsis</i> seedlings

Rapid Communications in Mass Spectrometry, 34(6).

By: M. Bagley  n, A. Stepanova n , M. Ekelöf n, J. Alonso  n & D. Muddiman n 

MeSH headings : Arabidopsis / chemistry; Arabidopsis / genetics; Arabidopsis Proteins / genetics; Indoleacetic Acids / analysis; Indoles / analysis; Mutation; Oximes / analysis; Oxygenases / genetics; Seedlings / chemistry; Seedlings / genetics; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: IAA doping of agarose was demonstrated as a viable technique for relative quantification of metabolites in live seedlings or tissues with similar biological considerations and was shown to be an appropriate sampling surface for IR-MALDESI mass spectrometry imaging of Arabidopsis seedlings. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: March 10, 2020

2018 journal article

IR-MALDESI mass spectrometry imaging of underivatized neurotransmitters in brain tissue of rats exposed to tetrabromobisphenol A

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410(30), 7979–7986.

By: M. Bagley  n, M. Ekelof n, K. Rock n, H. Patisaul n  & D. Muddiman n 

author keywords: IR-MALDESI; Neurotransmitters; Mass spectrometry imaging; Exposomics; Orbitrap
MeSH headings : Animals; Brain; Female; Infrared Rays; Neurotransmitter Agents / chemistry; Polybrominated Biphenyls / toxicity; Rats; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: This study serves as a demonstration of a new application of IR-MALDESI, namely that neurotransmitter distributions can be confidently and rapidly imaged without derivatization, and is used for the analysis of neurotransmitters in the brains of rats exposed to TBBPA in gestation and lactation through their mothers. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 3, 2018

2017 journal article

Mass spectrometric detection of chlorophyll a and the tetrapyrrole secondary metabolite tolyporphin A in the filamentous cyanobacterium HT-58-2. Approaches to high-throughput screening of intact cyanobacteria

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 21(11), 759–768.

By: Y. Zhang n, R. Zhang n, M. Nazari  n, M. Bagley n, E. Miller n , P. Williams *, D. Muddiman n , J. Lindsey n 

author keywords: IR-MALDESI-FTMS; MS/MS; MALDI-TOF-MS; chlorophyll; bacteriochlorin; high-throughput screening
TL;DR: Examination by MALDI-TOF-MS of lipophilic crude extracts of small-scale HT-58-2 samples without chromatographic fractionation enabled semi-quantitation of tolyporphin A over a 41-day growth period. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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