@article{tsuruta_sears_rebuli_weitz_durham_clapp_hill_ostrowski_dayton_caughey_2024, title={Development of an inhalable contrast agent targeting the respiratory tract mucus layer for pulmonary ultrasonic imaging}, volume={14}, ISSN={["2045-2322"]}, DOI={10.1038/s41598-024-80933-x}, abstractNote={Impaired mucociliary transport is a distinguishing sign of cystic fibrosis, but current methods of evaluation are invasive or expose young patients to ionizing radiation. Contrast-enhanced ultrasound imaging may provide a feasible alternative. We formulated a cationic microbubble ultrasound contrast agent, to optimize adhesion to the respiratory mucus layer when inhaled. Potential toxicity was evaluated in human bronchial epithelial cell (hBEC) cultures following a 24-hour exposure, compared to positive and negative control conditions. In vivo tolerability and pulmonary image enhancement feasibility were evaluated in mice, comparing oropharyngeal administration of contrast agent to saline control. When induced to flow across mucus plated on microscope slides, cationic microbubbles demonstrated greater affinity for target samples than standard microbubbles. Cationic microbubbles elicited no proinflammatory or cytotoxic response in hBECs, nor were any cross-links to the cilia observed. Unlike standard microbubbles, cationic microbubbles mixed into the mucus layer, without epithelial absorption, and were observed to move with the mucus layer by the action of mucociliary transport. When administered to mice, cationic microbubbles enhanced sonographic visualization of the trachea, and were well-tolerated with no adverse effects. This developmental work supports the safety and feasibility of a mucus-targeting contrast agent that may be useful for pulmonary ultrasound applications.}, number={1}, journal={SCIENTIFIC REPORTS}, author={Tsuruta, James K. and Sears, Patrick R. and Rebuli, Meghan E. and Weitz, Andrew S. and Durham, Phillip G. and Clapp, Phillip W. and Hill, David B. and Ostrowski, Lawrence E. and Dayton, Paul A. and Caughey, Melissa C.}, year={2024}, month={Dec} }
 @article{caughey_francis_karafin_2024, title={New and emerging technologies for pretransfusion blood quality assessment: A state-of-the-art review}, ISSN={["1537-2995"]}, DOI={10.1111/trf.18019}, journal={TRANSFUSION}, author={Caughey, Melissa C. and Francis, Richard O. and Karafin, Matthew S.}, year={2024}, month={Sep} }
 @article{chunawala_bhatt_qamar_vaduganathan_mentz_matsushita_grodin_pandey_caughey_2024, title={Peripheral artery disease, chronic kidney disease, and recurrent admissions for acute decompensated heart failure: The ARIC study}, volume={395}, ISSN={["1879-1484"]}, DOI={10.1016/j.atherosclerosis.2024.118521}, journal={ATHEROSCLEROSIS}, author={Chunawala, Zainali S. and Bhatt, Deepak L. and Qamar, Arman and Vaduganathan, Muthiah and Mentz, Robert J. and Matsushita, Kunihiro and Grodin, Justin L. and Pandey, Ambarish and Caughey, Melissa C.}, year={2024}, month={Aug} }
 @article{zhou_qiao_zhou_wasserman_caughey_2023, title={Detection of Dolichoectasia and Atherosclerosis by Automated MRA Tortuosity Metrics in a Population-Based Study}, ISSN={["1522-2586"]}, DOI={10.1002/jmri.28923}, abstractNote={Intracranial vessel tortuosity is a key component of dolichoectasia and has been associated with atherosclerosis and adverse neurologic outcomes. However, the evaluation of tortuosity is mainly a descriptive assessment.}, journal={JOURNAL OF MAGNETIC RESONANCE IMAGING}, author={Zhou, Shang and Qiao, Ye and Zhou, Xinwei and Wasserman, Bruce A. and Caughey, Melissa C.}, year={2023}, month={Jul} }
 @article{chunawala_caughey_bhatt_hendrickson_arora_bangalore_erwin_levisay_rosenberg_ricciardi_et al._2023, title={Mortality in Patients Hospitalized With Acute Myocardial Infarction Without Standard Modifiable Risk Factors: The ARIC Study Community Surveillance}, volume={12}, ISSN={["2047-9980"]}, DOI={10.1161/JAHA.122.027851}, abstractNote={Background Prevention strategies targeting standard modifiable cardiovascular risk factors (SMuRFs; diabetes, hypertension, smoking, hypercholesterolemia) are critical to improving cardiovascular disease outcomes. However, acute myocardial infarction (AMI) among individuals who lack 1 or more SMuRFs is not uncommon. Moreover, the clinical characteristics and prognosis of SMuRFless individuals are not well characterized. Methods and Results We analyzed AMI hospitalizations from 2000 to 2014 captured by the ARIC (Atherosclerosis Risk in Community) study community surveillance. AMI was classified by physician review using a validated algorithm. Clinical data, medications, and procedures were abstracted from the medical record. Main study outcomes included short- and long-term mortality within 28 days and 1 year of AMI hospitalization. Between 2000 and 2014, a total of 742 (3.6%) of 20 569 patients with AMI were identified with no documented SMuRFs. Patients without SMuRFs were less likely to receive aspirin, nonaspirin antiplatelet therapy, or beta blockers and less often underwent angiography and revascularization. Compared with those with one or more SMuRFs, patients without SMuRFs had significantly higher 28-day (odds ratio, 3.23 [95% CI, 1.78-5.88]) and 1-year (hazard ratio, 2.09 [95% CI, 1.29-3.37]) adjusted mortality. When examined across 5-year intervals from 2000 to 2014, the incidence of 28-day mortality significantly increased for patients without SMuRFs (7% to 15% to 27%), whereas it declined for those with 1 or more SMuRFs (7% to 5% to 5%). Conclusions Individuals without SMuRFs presenting with AMI have an increased risk of all-cause mortality with an overall lower prescription rate for guideline-directed medical therapy. These findings highlight the need for evidence-based pharmacotherapy during hospitalization and the need to discover new markers and mechanisms for early risk identification in this population.}, number={13}, journal={JOURNAL OF THE AMERICAN HEART ASSOCIATION}, author={Chunawala, Zainali S. and Caughey, Melissa C. and Bhatt, Deepak L. and Hendrickson, Michael and Arora, Sameer and Bangalore, Sripal and Erwin, John P. and Levisay, Justin P. and Rosenberg, Jonathan R. and Ricciardi, Mark J. and et al.}, year={2023}, month={Jul} }