Works (1)
Updated: July 5th, 2023 15:47
2011 journal article
Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution
MOLECULAR BIOLOGY OF THE CELL, 22(6), 892–905.
MeSH headings : Amino Acid Sequence; Cell Cycle Proteins / chemistry; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Chromosomal Proteins, Non-Histone / chemistry; Chromosomal Proteins, Non-Histone / genetics; Chromosomal Proteins, Non-Histone / metabolism; Directed Molecular Evolution; Endosomes / metabolism; Golgi Apparatus / metabolism; Models, Molecular; Molecular Dynamics Simulation; Molecular Sequence Data; Phenotype; Phosphatidylcholines / chemistry; Phosphatidylcholines / metabolism; Phosphatidylinositols / chemistry; Phosphatidylinositols / metabolism; Phospholipid Transfer Proteins / chemistry; Phospholipid Transfer Proteins / genetics; Phospholipid Transfer Proteins / metabolism; Protein Conformation; Saccharomyces cerevisiae / cytology; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / chemistry; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Sequence Alignment; Signal Transduction; trans-Golgi Network / metabolism
TL;DR:
A directed evolution approach is used as a novel prism through which the functional engineering of a Sec14-like phosphatidylinositol transfer protein can be observed.
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open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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