Works (90)
Updated: December 10th, 2024 05:02
2024 review
Advances and opportunities in process analytical technologies for viral vector manufacturing
[Review of ]. BIOTECHNOLOGY ADVANCES, 74.
author keywords: Biomanufacturing; Inline; At -line; Online; Viral Vectors; Gene Therapy; Process Analytical Technology; CQA; Viral Vector Characterization; Biosensors
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 8, 2024
2024 journal article
Development of Direct Electron Transfer-Type Extended Gate Field Effect Transistor Enzymatic Sensors for Metabolite Detection
ANALYTICAL CHEMISTRY, 96(10), 4076–4085.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 1, 2024
2024 journal article
Evaluating Bacterial Nanocellulose Interfaces for Recording Surface Biopotentials from Plants
SENSORS, 24(7).
author keywords: nanocellulose; electrophysiology; plant; electrode
open access via www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 15, 2024
2024 article
Hydrogel-Forming Microneedles and Applications in Interstitial Fluid Diagnostic Devices
Aroche, A. F., Nissan, H. E., & Daniele, M. A. (2024, November 19). ADVANCED HEALTHCARE MATERIALS.
author keywords: biosensor; hydrogel; interstitial fluid; microneedles; point-of-care
Source: Web Of Science
Added: December 2, 2024
2024 review
Insertable Biosensors: Combining Implanted Sensing Materials with Wearable Monitors
[Review of ]. ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 26, 197–221.
author keywords: biosensors; wearables; precision medicine; insertable; implantable
Sources: Web Of Science, NC State University Libraries
Added: September 9, 2024
2024 article
Multiangle Light Scattering as a Lentivirus Purification Process Analytical Technology
Sripada, S. A., Barbieri, E., Shastry, S., Wuestenhagen, E., Aldinger, A., Rammo, O., … Menegatti, S. (2024, May 28). ANALYTICAL CHEMISTRY, Vol. 5.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 11, 2024
2024 journal article
Peptide ligands for the affinity purification of adenovirus from HEK293 and vero cell lysates
JOURNAL OF CHROMATOGRAPHY A, 1736.
author keywords: Affinity chromatography; Adenovirus; Viral vectors; Gene therapy; Peptide ligands
Sources: Web Of Science, NC State University Libraries
Added: October 14, 2024
2024 article
Peptide ligands for the universal purification of exosomes by affinity chromatography
Kilgore, R. E., Moore, B. D., Sripada, S. A., Chu, W., Shastry, S., Barbieri, E., … Menegatti, S. (2024, August 4). BIOTECHNOLOGY AND BIOENGINEERING, Vol. 8.
author keywords: affinity chromatography; bioseparations; exosomes; gene delivery; peptide ligands
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 14, 2024
2024 article
Percutaneous Wearable Biosensors: A Brief History and Systems Perspective
Peterson, K. L., Shukla, R. P., & Daniele, M. A. (2024, October 20). ADVANCED SENSOR RESEARCH.
author keywords: biosensor; continuous; microneedle; percutaneous; subcutaneous; wearable
Source: Web Of Science
Added: October 28, 2024
2024 journal article
Quantifying Visual Differences in Drought-Stressed Maize through Reflectance and Data-Driven Analysis
AI, 5(2), 790–802.
author keywords: crop health monitoring; drought-stress detection; remote sensing; near-infrared; pixel extraction; classification
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 8, 2024
2024 journal article
Serotype-agnostic affinity purification of adeno-associated virus (AAV) via peptide-functionalized chromatographic resins
JOURNAL OF CHROMATOGRAPHY A, 1734.
author keywords: Gene therapy; Adeno-associated virus; Peptide ligands; Affinity chromatography; Transduction activity
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 1, 2024
2023 review
Advances in Modeling and Interpretability of Deep Neural Sleep Staging: A Systematic Review
[Review of ]. PHYSIOLOGIA, 4(1), 1–42.
author keywords: sleep stage classification; EEG; ECG; deep learning; contrastive learning; transfer learning; data augmentation; interpretability
TL;DR:
An improvement in performance up to 12% on standard datasets over the last 5 years is identified and the causes for these trends seem to be caused by incorporating new architectural components, such as the use of transformers and contrastive learning.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 1, 2024
2023 journal article
Biodegradable elastomeric circuit boards from citric acid-based polyesters
NPJ FLEXIBLE ELECTRONICS, 7(1).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023
2023 article
Conformal Micropatterned Organic-Metal Electrodes for Physiological Recording
2023 IEEE SENSORS.
author keywords: conformal electrodes; biopotential recording; microfabrication; photolithography; PEDOT:PSS
TL;DR:
CMOM electrodes were characterized then evaluated in vivo against commercial-off-the-shelf electrodes and PEDOT:PSS coating found to reduce the overall impedance in each electrode variant, resulting in a >97% decrease in impedance at low frequencies.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 1, 2024
2023 journal article
Hypoxia Primes Human ISCs for Interleukin-Dependent Rescue of Stem Cell Activity
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 16(5), 823–846.
author keywords: Inflammatory Hypoxia; Microphysiological System; Intestinal Stem Cells; Stem Cell Priming; Oxygen Sensor; Cytokines
TL;DR:
A new microphysiological system (MPS) is presented to investigate how hypoxia affects hISCs from healthy donors and test the hypothesis that prolongedHypoxia modulates how hISC respond to inflammation-associated interleukins (ILs) and has important implications for understanding intestinal epithelial regeneration mechanisms caused by inflammatory hypoxIA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 6, 2023
2023 article
Liquid Metal Coated Textiles with Autonomous Electrical Healing and Antibacterial Properties
Yang, J., Nithyanandam, P., Kanetkar, S., Kwon, K. Y., Ma, J., Im, S., … Dickey, M. D. (2023, April 2). ADVANCED MATERIALS TECHNOLOGIES, Vol. 4.
author keywords: gallium; mechanical sintering; breathable e-textile; healing; wearable electronics; antibacteria
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 24, 2023
2023 journal article
Molecular Engineering of Cyclic Azobenzene‐Peptide Hybrid Ligands for the Purification of Human Blood Factor VIII via Photo‐Affinity Chromatography
Advanced Functional Materials, 33(14).
author keywords: affinity ligands; azobenzene-peptide hybrids; biomolecular recognition; factor VIII; photo-affinity chromatography
TL;DR:
The cyclic azobenzene‐peptide ligands introduced in this report demonstrate a novel route integrating gentle operational conditions in a rapid and efficient bioprocess for the purification of life‐saving biotherapeutics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: February 20, 2023
2023 article
One-Step Quantification of anti-Covid-19 Antibodies via Dual Affinity Ratiometric Quenching Assays
Kilgour, K. M., Turner, B. L., Daniele, M., & Menegatti, S. (2023, June 27). ANALYTICAL CHEMISTRY, Vol. 6.
MeSH headings : Animals; Cricetinae; Humans; COVID-19 / diagnosis; SARS-CoV-2; CHO Cells; Cricetulus; Antibodies, Viral
TL;DR:
Evaluated the performance of the Dual-Affinity Ratiometric Quenching (DARQ) assay for the quantification of anti-SARS-CoV-2 antibodies in bioprocess harvests and intermediate fractions and human fluids indicates that the DARQ assay is a highly reproducible and rapid test, whose sensitivity, limit of detection, and dynamic range are independent of sample complexity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 10, 2023
2023 article
Peptide ligands for the affinity purification of adeno-associated viruses from HEK 293 cell lysates
Chu, W., Shastry, S., Barbieri, E., Prodromou, R., Greback-Clarke, P., Smith, W., … Menegatti, S. (2023, July 12). BIOTECHNOLOGY AND BIOENGINEERING, Vol. 7.
author keywords: adeno-associated virus; affinity chromatography; HEK 293 lysate; peptide ligands; virus purification
MeSH headings : Humans; Dependovirus / genetics; HEK293 Cells; Ligands; Peptides / genetics; Peptides / metabolism; Amino Acid Sequence; Genetic Vectors
TL;DR:
Peptide ligands that selectively capture AAVs and release them under mild conditions are introduced, affording high recovery, high recovery of host cell proteins (HCPs), and high transduction activity of the purified viruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 7, 2023
2023 article
Rational design and experimental evaluation of peptide ligands for the purification of adeno-associated viruses via affinity chromatography
Shastry, S., Chu, W., Barbieri, E., Greback-Clarke, P., Smith, W. K., Cummings, C., … Menegatti, S. (2023, September 28). BIOTECHNOLOGY JOURNAL, Vol. 9.
author keywords: adeno-associated virus; affinity chromatography; gene therapy; peptide ligands; transduction activity
TL;DR:
This study introduces a cohort of peptide ligands that mimic the biorecognition activity of the AAV receptor (AAVR) and anti-AAV antibody A20, enable product elution under near-physiological conditions (pH 6.0) and grant extended reusability by withstanding multiple regenerations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 10, 2023
2023 article
Toward the quantification of adeno-associated virus titer by electrochemical impedance spectroscopy
2023 IEEE BIOSENSORS CONFERENCE, BIOSENSORS.
author keywords: adeno-associated virus; AAV2; immunosensor; electrochemical impedance spectroscopy; viral vector
TL;DR:
The preliminary development of an immunosensor for measuring the titer of adeno-associated virus 2 (AAV2), which may be deployed for rapid quantification of product yield during AAV biomanufacturing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 4, 2023
2023 article
Towards electrochemical control of pH for regeneration of biosensors
2023 IEEE BIOSENSORS CONFERENCE, BIOSENSORS.
author keywords: palladium; regeneration; affinity; pH; immunosensor
TL;DR:
The development of a “solid-state” regeneration method provides significant value for extending the utility of affinity-based biosensors, such as electrochemical immunosensors and aptasensors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 4, 2023
2022 article
A Low-Cost, Open Source Wireless Body Area Network for Clinical Gait Rehabilitation
2022 IEEE SENSORS.
author keywords: wearable; wireless body area network; inertial measurement unit; gait rehabilitation; biomechanics; vertical; ground reaction force
TL;DR:
An inexpensive I MU-based wireless body area network capable of recording 9-axis motion data from 8 sites on the body simultaneously capable of generating data comparable to existing commercial sensor networks is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 27, 2023
2022 journal article
Electrospun Carbon Nanotube-Based Scaffolds Exhibit High Conductivity and Cytocompatibility for Tissue Engineering Applications
ACS OMEGA, 7(23), 20006–20019.
TL;DR:
The increased conductivity and high cytocompatibility of the CNT-incorporated scaffolds make them appropriate candidates for future use in cardiac and neural tissue engineering.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 4, 2022
2022 journal article
Forabot: Automated Planktic Foraminifera Isolation and Imaging
GEOCHEMISTRY GEOPHYSICS GEOSYSTEMS, 23(12).
author keywords: foraminifera; automation; classification
TL;DR:
The presented work describes Forabot, an open‐source system which can physically manipulate individual foraminifera for imaging and isolation with minimal human interaction, and is able to be built by researchers for a low cost, effectively manipulate foram with few mistakes, provide quality images for future research, and classify the species of imaged forams.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 10, 2023
2022 article
Real-Time Monitoring of Plant Stalk Growth Using a Flexible Printed Circuit Board Sensor
2022 IEEE SENSORS.
author keywords: Plant growth; circumferential sensor; mechanical sensing; multiplexer; crop monitoring; maize; electrode array
UN Sustainable Development Goal Categories
1. No Poverty
(Web of Science)
2. Zero Hunger
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 27, 2023
2022 article
Toward an Aptasensor for Monitoring of Tacrolimus
2022 IEEE SENSORS.
author keywords: aptamer; tacrolimus; surface plasmon resonance; square wave voltammetry
TL;DR:
A multi-aptamer system to extend the dynamic range and improve surface functionality to limit non-specific binding is explored and limited specificity for the TAC aptasensors was observed with SWV against cyclosporine, amoxicillin, and tetracycline.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 27, 2023
2022 article
Wireless Wearable Electrochemical Sensing Platform with Zero- Power Osmotic Sweat Extraction for Continuous Lactate Monitoring
Saha, T., Songkakul, T., Knisely, C. T., Yokus, M. A., Daniele, M. A., Dickey, M. D., … Velev, O. D. (2022, July 12). ACS SENSORS, Vol. 7.
author keywords: paper microfluidics; sweat; wearable device; electrochemical sensor; lactate; osmotic pumping; hydrogel
MeSH headings : Humans; Lactic Acid / analysis; Monitoring, Physiologic; Osmosis; Sweat / chemistry; Wearable Electronic Devices
TL;DR:
A wearable system combining a hydrogel for osmotic sweat extraction, with a paper microfluidic channel for facilitating sweat transport and management, a screen-printed electrochemical lactate sensor, and a custom-built wireless wearable potentiostat system holds the potential of providing comprehensive and long-term continuous analysis of sweat lactate trends in the human body during rest and under exercising conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 13, 2022
2021 article
A Wearable Patch for Prolonged Sweat Lactate Harvesting and Sensing
2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC), pp. 6863–6866.
MeSH headings : Humans; Hydrogels; Lactic Acid; Sweat; Sweating; Wearable Electronic Devices
TL;DR:
The on-skin performance of a non-invasive wearable sweat sampling patch that can harvest sweat at rest, during exercise, and post-exercise is reported, which can potentially provide useful information about the human metabolic activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 25, 2022
2021 journal article
Engineering Next Generation Cyclized Peptide Ligands for Light-Controlled Capture and Release of Therapeutic Proteins
ADVANCED FUNCTIONAL MATERIALS, 31(27).
author keywords: azobenzene; cyclized peptide; light‐ controlled biorecognition; microfluidic devices; photochromic switch; photo‐ isomerization kinetics
TL;DR:
A framework for prototyping photo‐affinity adsorbents comprising azobenzene‐cyclized peptides (ACPs) conjugated to translucent porous beads (ChemMatrix) and it is demonstrated that the isomerization at different light intensities is correlated to the cyclization geometry.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 24, 2021
2021 journal article
Fibrin-modulating nanogels for treatment of disseminated intravascular coagulation
Blood Advances, 5(3), 613–627.
MeSH headings : Disseminated Intravascular Coagulation / drug therapy; Fibrin; Humans; Microcirculation; Nanogels; Thrombosis / drug therapy
TL;DR:
In vivo and in vivo, tPA-FSNs decreased the presentation of multiorgan microthrombi, recovered platelet counts, and improved bleeding outcomes in a DIC rodent model, demonstrating that a fibrinolytic agent loaded into fibrin-targeting nanogels could improve DIC outcomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: March 22, 2021
2021 journal article
Integrated non-invasive biochemical and biophysical sensing systems for health and performance monitoring: A systems perspective
BIOSENSORS & BIOELECTRONICS, 184.
author keywords: Wearable; Biosensor; Sweat; Epidermal; Multiplexed systems
MeSH headings : Biosensing Techniques; Electronics; Monitoring, Physiologic; Sweat; Wearable Electronic Devices
TL;DR:
A review of recent developments in wearable biochemical and biophysical systems is provided, which addresses how sweat collection and sample handling platforms may be a rate limiting technology to realizing the clinical translation of wearable health monitoring systems and a snapshot of integrated wireless wearable systems with multimodal sensing capabilities is assessed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 10, 2021
2021 journal article
Microphysiological System for High-Throughput Computer Vision Measurement of Microtissue Contraction
ACS SENSORS, 6(3), 985–994.
author keywords: high throughput; 3D culture; tissue function; tissue contraction; computer vision
MeSH headings : Computers; Fibroblasts; High-Throughput Screening Assays; Humans; Image Processing, Computer-Assisted
TL;DR:
An inexpensive, versatile, high-throughput platform to measure microtissue contraction in a 96-well plate configuration using one-step batch imaging and an algorithm uses pixel-based image analysis and computer vision techniques for the accurate multiwell quantification of positional changes in the optical microprobes caused by the contraction of the microtissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 10, 2021
2021 journal article
Monitoring of random microvessel network formation by in-line sensing of flow rates: A numerical and in vitro investigation
SENSORS AND ACTUATORS A-PHYSICAL, 331.
author keywords: Microphysiological systems; Microfluidics; Equivalent circuit; Fluid mechanics; Vascular mechanics; Microvessels; Fluid networks
TL;DR:
A strategy to monitor the dynamic formation of microscale fluid networks, which can be translated to the monitoring of microvasculature development in engineered tissue constructs and illustrates the potential to precisely and non-destructively monitor microvessel network development and volumetric changes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: October 18, 2021
2021 article
Preliminary Evaluation of a Solar-Powered Wristband for Continuous Multi-Modal Electrochemical Monitoring
2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC), pp. 7316–7319.
MeSH headings : Electric Power Supplies; Humans; Solar Energy; Sweat; Wearable Electronic Devices; Wrist
TL;DR:
The presented solar-powered wearable system enables continuous wireless multi-modal electrochemical monitoring for uninterrupted sensing of metabolic biomarkers in sweat while harvesting energy from indoor lighting or sunlight.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 25, 2022
2021 article
Resorbable elastomers for implantable medical devices: highlights and applications
Turner, B., Ramesh, S., Menegatti, S., & Daniele, M. (2021, December 29). POLYMER INTERNATIONAL, Vol. 12.
author keywords: elastomers; implantable medical devices; resorbable; bioelectronics
Sources: Web Of Science, NC State University Libraries
Added: January 10, 2022
2021 journal article
Synthesis of sonicated fibrin nanoparticles that modulate fibrin clot polymerization and enhance angiogenic responses
Colloids and Surfaces B: Biointerfaces, 204, 111805.
author keywords: Fibrin; Nanoparticles; Wound healing; Regenerative medicine; Fibrin sealant
MeSH headings : Fibrin; Fibrin Tissue Adhesive; Nanoparticles; Polymerization; Wound Healing
TL;DR:
It is shown that SFBNs may be a promising wound healing therapy that can be easily produced and delivered in a flowable formulation and support cell migration in an in vitro angiogenic sprouting assay, relevant for wound healing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: July 19, 2021
2021 journal article
Synthetic Platelet Microgels Containing Fibrin Knob B Mimetic Motifs Enhance Clotting Responses
Advanced Therapeutics, 4(5).
author keywords: bleeding; Clotting; fibrin; hemostasis; microgel
TL;DR:
Soft microgels decorated with the peptide AHRPYAAK are found to significantly increase clot density in vitro and decrease bleeding in a rodent trauma model in vivo, indicating that FAMCYs are capable of recapitulating the platelet‐mimetic properties of previous designs while utilizing a less costly, more translational design.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 5, 2021
2021 journal article
Toward Automated Analysis of Fetal Phonocardiograms: Comparing Heartbeat Detection from Fetal Doppler and Digital Stethoscope Signals
2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 975–979.
Event: 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) at Mexico on November 1-5, 2021
MeSH headings : Female; Fetal Monitoring; Heart Rate; Humans; Neural Networks, Computer; Pregnancy; Signal Processing, Computer-Assisted; Stethoscopes
TL;DR:
This work implemented two neural network architectures for heartbeat detection on a set of fetal phonocardiogram signals captured using fetal Doppler and a digital stethoscope, and shows a Convolutional Neural Network is the most efficient at identifying the S1 waveforms in a heartbeat.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 25, 2022
2021 article
Toward Subcutaneous Electrochemical Aptasensors for Neuropeptide Y
2021 IEEE SENSORS.
author keywords: aptamer; biosensor; neuropeptide Y; flexible electronics; cyclic voltammetry; electrical impedance spectroscopy
TL;DR:
A biosensor for the detection of neuropeptide Y (NPY), a marker of stress, has been designed and tested for operation in a flexible microneedle form factor and shows a response to NPY over 400 pM to 200 nM when tested in KCl and K3[Fe(CN)6]/K4[Fe (CN) 6], and PBS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 28, 2022
2021 article
Towards Continuous Plant Bioimpedance Fitting and Parameter Estimation
2021 IEEE SENSORS.
author keywords: bioimpedance parameter extraction; equivalent circuit modelling; precision agriculture; cyberphysical systems
TL;DR:
This study developed a software pipeline to support impedance sensing applications and applied this to track longitudinal consistent bioimpedance data from the V4 leaf midrib in maize plants, demonstrating that the analysis of an example longitudinal dataset was able to reveal a time series for parameter fitting.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 28, 2022
2021 article
Ultrasound-Powered Implants: A Critical Review of Piezoelectric Material Selection and Applications
Turner, B. L., Senevirathne, S., Kilgour, K., McArt, D., Biggs, M., Menegatti, S., & Daniele, M. A. (2021, July 8). ADVANCED HEALTHCARE MATERIALS, Vol. 7.
author keywords: energy harvesting; implantable medical devices; piezoelectric devices; ultrasound; wireless power transfer
MeSH headings : Electric Power Supplies; Movement; Prostheses and Implants; Ultrasonography
TL;DR:
Among the various forms of WPT, ultrasound powering offers distinct advantages such as low tissue‐mediated attenuation, a higher approved safe dose (720 mW cm−2), and improved efficiency at smaller device sizes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 19, 2021
2020 journal article
Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs
ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(11), 6309–6320.
author keywords: microfluidics; cardiac patch; cardiac stromal cells; myocardial infarction; porcine model
MeSH headings : Animals; Microvessels; Myocardial Infarction / therapy; Myocytes, Cardiac; Neovascularization, Physiologic; Rats; Stromal Cells; Swine
TL;DR:
It is shown that BMV-CSC patch transplantation significantly promoted cardiac function, reduced scar size, increased viable myocardial tissue, promoted neovascularization, and suppressed inflammation in rat and porcine MI models, demonstrating enhanced therapeutic efficacy compared to conventional cardiac stromal cell patches.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 11, 2020
2020 journal article
Chitosan Hydrogels for Synergistic Delivery of Chemotherapeutics to Triple Negative Breast Cancer Cells and Spheroids
PHARMACEUTICAL RESEARCH, 37(7).
MeSH headings : Acetylation; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / chemistry; Antineoplastic Combined Chemotherapy Protocols / pharmacology; Cell Line, Tumor; Cell Survival / drug effects; Chitosan / chemistry; Deoxycytidine / administration & dosage; Deoxycytidine / analogs & derivatives; Deoxycytidine / chemistry; Deoxycytidine / pharmacology; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers; Drug Compounding; Drug Liberation; Drug Synergism; Female; Humans; Hydrogels; Kinetics; Spheroids, Cellular; Triple Negative Breast Neoplasms / drug therapy; Triple Negative Breast Neoplasms / pathology; Gemcitabine
TL;DR:
The ACS hydrogel delivery system accomplishes drug release kinetics and molar ratio that affords strong therapeutically synergism and provides a strong pre-clinical demonstration of the potential of the proposed system for complementing surgical resection of aggressive solid tumors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020
2020 journal article
Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids
ANALYTICAL CHEMISTRY, 92(24), 16274–16283.
MeSH headings : Animals; Antibodies, Monoclonal / analysis; Antibodies, Monoclonal / immunology; Antibodies, Monoclonal / therapeutic use; Antigens / immunology; CHO Cells; Cricetulus; Spectrometry, Fluorescence / methods
TL;DR:
A novel dual-affinity ratiometric quenching (DARQ) assay, which combines selective biorecognition andQuenching of fluorescence signals for rapid and sensitive quantification of therapeutic monoclonal antibodies (mAbs).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 11, 2021
2020 review
Editors' Choice-Critical Review-A Critical Review of Solid State Gas Sensors
[Review of ]. JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 167(3).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 22, 2020
2020 journal article
Microphysiological systems for the modeling of wound healing and evaluation of pro-healing therapies
Journal of Materials Chemistry B, 8(32), 7062–7075.
MeSH headings : Animals; Cell Culture Techniques; Cell Line; Cell Movement; Cellular Microenvironment; Hemostasis / drug effects; Humans; Hydrogels / chemistry; Hydrogels / metabolism; Macrophages / metabolism; Microfluidics; Models, Animal; Skin; Stereolithography; Wound Healing / drug effects
TL;DR:
This review provides a brief overview of the wound healing process and in vivo assays, and critically review the current state of microphysiological systems and supporting technologies for modelling and studying wound healing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: September 7, 2020
2020 journal article
Modified gaphene oxide (GO) particles in peptide hydrogels: a hybrid system enabling scheduled delivery of synergistic combinations of chemotherapeutics
JOURNAL OF MATERIALS CHEMISTRY B, 8(17), 3852–3868.
MeSH headings : Antibiotics, Antineoplastic / chemistry; Antibiotics, Antineoplastic / pharmacology; Cell Proliferation / drug effects; Cell Survival / drug effects; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Delivery Systems; Drug Screening Assays, Antitumor; Graphite / chemistry; Humans; Hydrogels / chemistry; Molecular Dynamics Simulation; Particle Size; Peptides / chemistry; Surface Properties; Tumor Cells, Cultured
TL;DR:
A homogeneous composite comprising modified graphene oxide (GO) nanoparticles embedded in a Max8 peptide hydrogel, which provides controlled kinetics and molar ratios of release of doxorubicin (DOX) and gemcitabine (GEM) and is tested against a triple negative breast cancer cell line.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020
2020 review
Past, Present, and Future of Affinity-based Cell Separation Technologies
[Review of ]. ACTA BIOMATERIALIA, 112, 29–51.
author keywords: Cell purification; Immunoaffinity; MACS; FACS; Microfluidics
MeSH headings : Cell Separation; Chromatography, Affinity; Flow Cytometry; Ligands; Regenerative Medicine
TL;DR:
This review discusses past and current methods for developing cell-targeting affinity ligands and their application in cell purification, along with the benefits and challenges associated with different purification formats, and presents new technologies towards improving the viability and throughput of cell products for tissue engineering and regenerative medicine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
9. Industry, Innovation and Infrastructure
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 3, 2020
2020 journal article
Photoinduced reconfiguration to control the protein-binding affinity of azobenzene-cyclized peptides
JOURNAL OF MATERIALS CHEMISTRY B, 8(33), 7413–7427.
MeSH headings : Amino Acid Sequence; Azo Compounds / chemistry; Hydrogen-Ion Concentration; Isomerism; Osmolar Concentration; Peptides, Cyclic / chemistry; Photochemical Processes
TL;DR:
This study demonstrates a general method to develop azobenzene-cyclized peptide ligands with light-controlled affinity for target proteins by designing photo-switchable peptides targeting vascular cell adhesion marker 1 (VCAM1), a cell marker implicated in stem cell function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 14, 2020
2020 journal article
Rational design of direct electron transfer type L-lactate dehydrogenase for the development of multiplexed biosensor
BIOSENSORS & BIOELECTRONICS, 176.
author keywords: L-lactate oxidase; Direct electron transfer; Fusion protein; Site-directed mutagenesis; Multiplexed biosensor; Biomedical engineering
MeSH headings : Biosensing Techniques; Blood Glucose; Blood Glucose Self-Monitoring; Electrodes; Electrons; Glucose; Glucose Oxidase; L-Lactate Dehydrogenase
TL;DR:
This is the first report of the DET-type enzyme based lactate and glucose dual sensing systems and the impact of the presence of electrochemical interferants was revealed to be negligible.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 8, 2021
2020 journal article
Rheological Properties of Coordinated Physical Gelation and Chemical Crosslinking in Gelatin Methacryloyl (GelMA) Hydrogels
MACROMOLECULAR BIOSCIENCE, 20(12).
author keywords: animal source; gelatin; gelatin methacryloyl; gelation; GelMA; mechanical properties; photopolymerization
MeSH headings : Animals; Biocompatible Materials / chemistry; Bioprinting / methods; Cattle; Gelatin / chemistry; Hydrogels / chemistry; Methacrylates / chemistry; Printing, Three-Dimensional; Rheology; Swine; Tissue Engineering / trends
TL;DR:
The effects of coordinated physical gelation and chemical crosslinking are demonstrated by precise photopatterning of cell-laden microstructures, inducing different cellular behavior depending on the selected mechanical properties of GelMA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 14, 2020
2020 journal article
Wearable multiplexed biosensor system toward continuous monitoring of metabolites
BIOSENSORS & BIOELECTRONICS, 153.
author keywords: Wearable; Multiplex; Potentiostat; Electrochemical sensors; Glucose; Lactate; pH; Sweat sensors
MeSH headings : Biosensing Techniques / instrumentation; Dimethylpolysiloxanes / chemistry; Electrochemical Techniques; Electrodes; Glucose / analysis; Humans; Hydrogen-Ion Concentration; Lactic Acid / analysis; Metabolome / physiology; Monitoring, Physiologic / instrumentation; Skin Temperature; Surface Properties; Sweat / chemistry; Wearable Electronic Devices
TL;DR:
The design and characterization of a wearable system with a flexible sensor array for non-invasive and continuous monitoring of human biochemistry and future evaluation of temporal changes of the sweat biomarkers is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 23, 2020
2019 review
Measuring and regulating oxygen levels in microphysiological systems: design, material, and sensor considerations
[Review of ]. ANALYST, 144(10), 3190–3215.
MeSH headings : Animals; Cell Line; Humans; Lab-On-A-Chip Devices; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods; Models, Biological; Oxygen / analysis; Oxygen / metabolism
TL;DR:
Comparisons of organ-specific MPS that do and do not consider oxygen microenvironments are offered and materials used in microphysiological models are analyzed in terms of their ability to control oxygen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 22, 2019
2019 review
Monitoring of Microphysiological Systems: Integrating Sensors and Real-Time Data Analysis toward Autonomous Decision-Making
[Review of ]. ACS SENSORS, 4(6), 1454–1464.
author keywords: microphysiological system (MPS); organ-on-chip; biosensor; real-time analysis; data; cyber-physical system
MeSH headings : Data Analysis; Humans; Lab-On-A-Chip Devices; Machine Learning; Microchip Analytical Procedures / methods; Monitoring, Physiologic / instrumentation; Monitoring, Physiologic / methods
TL;DR:
In this Perspective, three stages of microphysiological system monitoring, including process, development, and function, are assessed and the unique features and remaining technical challenges for the required sensors are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 22, 2019
2019 journal article
Perylene-diimide-based n-type semiconductors with enhanced air and temperature stable photoconductor and transistor properties
DYES AND PIGMENTS, 174.
author keywords: Perylene; n-type; Photoconductor; Field effect transistor; Air stable
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science; OpenAlex)
Source: Web Of Science
Added: February 17, 2020
2018 journal article
Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction
ACS APPLIED MATERIALS & INTERFACES, 10(39), 33088–33096.
author keywords: microvessels; hydrodynamic focusing; cardiac stem cells; cardiomyocyte proliferation; angiogenesis; myocardial infarction
MeSH headings : Animals; Cells, Cultured; Female; Human Umbilical Vein Endothelial Cells; Humans; Microfluidic Analytical Techniques; Myocardial Infarction / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / physiology; Neovascularization, Physiologic / physiology; Rats; Rats, Nude; Stem Cells / cytology; Stem Cells / physiology
TL;DR:
It is shown that the endothelialized BMVs mimicked the natural architecture and function of capillaries and that the resultant vascularized cardiac patch (BMV-CSC patch) exhibited equivalent release of paracrine factors compared to those of coculture of genuine human CSCs and HUVECs after 7 days of in vitro culture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 29, 2018
2018 journal article
IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 7(1), 1–17.
author keywords: Intestinal Stem Cells; Interleukin-22; Inflammatory Bowel Disease
MeSH headings : Animals; Biomarkers / metabolism; Cell Lineage / drug effects; Cell Proliferation / drug effects; Cell Self Renewal / drug effects; Cellular Microenvironment / drug effects; Computer Simulation; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ileum / cytology; Inflammatory Bowel Diseases / pathology; Interleukins / pharmacology; Mice, Inbred C57BL; Models, Biological; Organoids / cytology; Organoids / drug effects; Organoids / metabolism; Receptors, Interleukin / metabolism; Serum / metabolism; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / metabolism
TL;DR:
Increased IL22 limits ISC expansion in favor of increased TA progenitor cell expansion, and chronically increased IL22 levels, similar to predicted microenvironment levels, showed increases in proliferative cells in the TA zone with no increase in ISCs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 14, 2019
2018 journal article
Integrated phosphorescence-based photonic biosensor (iPOB) for monitoring oxygen levels in 3D cell culture systems
BIOSENSORS & BIOELECTRONICS, 123, 131–140.
author keywords: Oxygen; Microdevice; Organs-on-chips; Oxygen biosensor; Biosensors; Hypoxia
MeSH headings : Biosensing Techniques; Cell Culture Techniques; Cell Hypoxia; Cell Line, Tumor; Humans; Luminescent Measurements / methods; Oxygen / chemistry; Oxygen / metabolism; Photons
TL;DR:
The design and engineering of a system to remotely monitor and control oxygen concentration inside a device for 3D cell culture is reported, integrating a photonic oxygen biosensor into the 3D tissue scaffold and regulate oxygen concentration via the control of purging gas flow.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 3, 2018
2018 journal article
Neuro Interfaces: Neuro-Nano Interfaces: Utilizing Nano-Coatings and Nanoparticles to Enable Next-Generation Electrophysiological Recording, Neural Stimulation, and Biochemical Modulation (Adv. Funct. Mater. 12/2018)
Advanced Functional Materials, 28(12), 1870079.
Source: Crossref
Added: December 11, 2020
2017 journal article
Electrolyte-Sensing Transistor Decals Enabled by Ultrathin Microbial Nanocellulose
Scientific Reports, 7(1).
MeSH headings : Animals; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Cellulose / chemistry; Chickens; Electrochemical Techniques; Electrolytes / analysis; Gluconacetobacter xylinus / metabolism; Nanostructures / chemistry; Porosity; Skin / metabolism; Transistors, Electronic
TL;DR:
An ultra-thin electronic decal that can simultaneously collect, transmit and interrogate a bio-fluid and allows for the physical isolation of the electronics from the human body while enabling efficient bio- fluid delivery to the transistor via vertical wicking.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
2017 journal article
Microfabricated blood vessels undergo neoangiogenesis
BIOMATERIALS, 138, 142–152.
author keywords: Sheath-flow microfluidics; Blood vessel; Angiogenesis; Anastomoses; Perfusion
MeSH headings : Capillaries / chemistry; Coculture Techniques; Endothelial Cells / cytology; Endothelial Cells / metabolism; Extracellular Matrix Proteins / metabolism; Feeder Cells; Fibroblasts / cytology; Fibroblasts / metabolism; Gelatin / chemistry; Humans; Hydrogels / chemistry; Microfluidics / methods; Microtechnology / methods; Microvessels / growth & development; Microvessels / ultrastructure; Neovascularization, Physiologic; Perfusion; Pericytes / cytology; Pericytes / metabolism; Polyhydroxyethyl Methacrylate / chemistry; Primary Cell Culture; Tissue Engineering / methods; Umbilical Veins / cytology
TL;DR:
Ultraviolet (UV) photo-crosslinkable poly(ethylene glycol) and gelatin methacrylate polymers used in combination with sheath-flow microfluidics allow for the fabrication of small diameter blood vessels which undergo neoangiogenesis as well as other developmental processes associated with normal human blood vessel maturation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Neuro-Nano Interfaces: Utilizing Nano-Coatings and Nanoparticles to Enable Next-Generation Electrophysiological Recording, Neural Stimulation, and Biochemical Modulation
Advanced Functional Materials, 28(12), 1700239.
author keywords: blood-brain barrier; brain; nanoparticle; neural interface; neurostimulation
TL;DR:
The use of nanomaterials to improve current electrophysiological interfaces, as well as enable new nano‐interfaces to modulate neural activity via alternative mechanisms, such as remote transduction of electromagnetic fields are explored.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2017 article
Wound Healing and the Host Response in Regenerative Engineering
ENCYCLOPEDIA OF BIOMEDICAL ENGINEERING, VOL 1, pp. 707–718.
TL;DR:
The purpose of this book chapter is to highlight the cellular processes and bioactive agents that encompass the wound healing process and to discuss how these processes change in the presence of a biomaterial.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 14, 2020
2017 journal article
“Data characterizing microfabricated human blood vessels created via hydrodynamic focusing”
“Data characterizing microfabricated human blood vessels created via hydrodynamic focusing.” Data in Brief, 14, 156–162.
author keywords: Microfluidics; Ge1MA; Endothelial cell; Blood vessel; Microvessel; Organ-on-chip
TL;DR:
Data is reported regarding the construction of blood vessels including cellular composition and cell positioning within the engineered vascular construct as well as functional aspects of the tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2016 journal article
Affinity purification of bacterial outer membrane vesicles (OMVs) utilizing a His-tag mutant
Research in Microbiology, 168(2), 139–146.
MeSH headings : Bacterial Outer Membrane Proteins / chemistry; Bacterial Outer Membrane Proteins / isolation & purification; Chromatography, Affinity / methods; Escherichia coli / chemistry; Escherichia coli / genetics; Escherichia coli / growth & development; Escherichia coli / ultrastructure; Extracellular Vesicles / chemistry; Genetic Engineering / methods; Histidine / genetics; Lac Operon; Oligopeptides / genetics; Plasmids / genetics; Recombinant Proteins / isolation & purification
TL;DR:
Two plasmid constructs that utilize a truncated, transmembrane protein to present an exterior histidine repeat sequence are developed that can be utilized to enhance basic research capabilities in the area of elucidating endogenous OMV function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2016 conference paper
Integration of biochemical sensors into wearable biomaterial platforms
Smart biomedical and physiological sensor technology xiii, 9863.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Microvessel manifold for perfusion and media exchange in three-dimensional cell cultures
Biomicrofluidics, 10(5), 054109.
TL;DR:
An inclusive on-chip platform that is capable of maintaining laminar flow through porous biosynthetic microvessels and characterize the diffusion of small molecules from the perfusate, across the microvessel wall, and into the matrix of a 3D cell culture is developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2016 conference paper
Nanocellulose electrodes for interfacing plant electrochemistry
2016 ieee sensors.
Source: NC State University Libraries
Added: August 6, 2018
2016 review
Nanoparticles and direct immunosuppression
[Review of ]. EXPERIMENTAL BIOLOGY AND MEDICINE, 241(10), 1064–1073.
author keywords: Nanoparticles; immunosuppression; bionanoscience; nanotoxicology; immunotoxicity; anti-inflammatory
MeSH headings : Animals; Drug Carriers / metabolism; Humans; Immunosuppression Therapy / methods; Immunosuppressive Agents / pharmacokinetics; Immunosuppressive Agents / pharmacology; Nanoparticles / metabolism
TL;DR:
The state-of-the-art and developments in understanding how nanoparticles induce immunosuppressive responses are summarized, the inherent properties of nanomaterials which induce these immunological reactions are compared, and the potential for using nanommaterials to modulate and control the immune system is commented on.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Platinum Nanoparticle Decorated SiO2 Microfibers as Catalysts for Micro Unmanned Underwater Vehicle Propulsion
ACS APPLIED MATERIALS & INTERFACES, 8(45), 30941–30947.
author keywords: platinum nanoparticles; silicon microfibers; propulsion; hydrogen peroxide; micro unmanned underwater vehicles
TL;DR:
The concomitance of facile fabrication, economic and scalable processing, and high performance-including a reduction in H2O2 decomposition activation energy of 40-50% over conventional material catalysts-paves the way for using these nanostructured microfibers in modern, small-scale underwater vehicle propulsion systems.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Sequestering survivin to functionalized nanoparticles: a strategy to enhance apoptosis in cancer cells
Biomaterials Science, 4(4), 614–626.
MeSH headings : Acrylates / chemistry; Apoptosis / physiology; Azides / chemistry; Azides / pharmacology; Catalysis; Cell Line, Tumor; Copper / chemistry; Cycloaddition Reaction; Humans; Inhibitor of Apoptosis Proteins / chemistry; Inhibitor of Apoptosis Proteins / metabolism; Inhibitor of Apoptosis Proteins / pharmacology; Ligands; Microtubule-Associated Proteins / chemistry; Microtubule-Associated Proteins / metabolism; Nanoparticles / chemistry; Neoplasm Proteins / chemistry; Neoplasm Proteins / metabolism; Polymers / chemistry
TL;DR:
Using affinity pull-down studies, it was determined that the PA/azTM nanoparticles selectively bind survivin and the particles can enhance apoptotic cell death in glioblastoma cell lines and other survivin over-expressing cell lines such as A549 and MCF7 relative to cells incubated with the original Abbott-derived small molecule inhibitor.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2016 journal article
Skin Hydration Sensor for Customizable Electronic Textiles
MRS ADVANCES, 1(38), 2671–2676.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Topically applied manganese-porphyrins BMX-001 and BMX-010 display a significant anti-inflammatory response in a mouse model of allergic dermatitis
ARCHIVES OF DERMATOLOGICAL RESEARCH, 308(10), 711–721.
author keywords: Superoxide dismutase mimics; BMX-010; BMX-001; Allergic dermatitis; Mice
MeSH headings : Administration, Cutaneous; Administration, Oral; Animals; Cell Line; Dendritic Cells / drug effects; Dendritic Cells / metabolism; Dermatitis, Allergic Contact / drug therapy; Disease Models, Animal; Ear; Female; Humans; Infant, Newborn; Inflammation / drug therapy; Inflammation / metabolism; Interleukin-1beta / metabolism; Interleukin-4 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Metalloporphyrins / administration & dosage; Metalloporphyrins / therapeutic use; Mice; Mice, Inbred BALB C; Pruritus / drug therapy; Skin / drug effects; Skin / metabolism; Skin Cream; Superoxide Dismutase / metabolism; Toluene 2,4-Diisocyanate / toxicity; p-Methoxy-N-methylphenethylamine / toxicity
TL;DR:
Topical treatment with BMX cream resulted in a significant decrease in scratching behaviour in the compound 48/80 model, but not in the TDI model, and interestingly, the concentration of the cytokines IL-1β and IL-4 in inflamed skin was reduced by 80–90 % by all treatment options.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 conference paper
Towards a sweat-based wireless and wearable electrochemical sensor
2016 ieee sensors.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Bacterial Nanobioreactors–Directing Enzyme Packaging into Bacterial Outer Membrane Vesicles
ACS Applied Materials & Interfaces, 7(44), 24963–24972.
author keywords: outer membrane vesicle (OMV); phosphotriesterase (PTE); directed packaging enzyme; E. coli; SpyCatcher; SpyTag
MeSH headings : Bacterial Outer Membrane Proteins / chemistry; Bioreactors; Crystallography, X-Ray; Electrophoresis, Polyacrylamide Gel; Enzymes / chemistry; Escherichia coli / metabolism; Freezing; Microscopy, Electron, Scanning; Nanotechnology / methods; Phosphoric Triester Hydrolases / chemistry; Plasmids / metabolism; Protein Structure, Tertiary; Recombinant Fusion Proteins / chemistry
TL;DR:
The coexpression of OmpA-ST with PTE-SC greatly improved the overall PTE production levels by mitigating toxicity through exporting of the Pte-SC and greatly enhanced packaged enzyme stability against iterative cycles of freezing and thawing.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2015 journal article
Microfluidics: Microfluidic Strategies for Design and Assembly of Microfibers and Nanofibers with Tissue Engineering and Regenerative Medicine Applications (Adv. Healthcare Mater. 1/2015)
Advanced Healthcare Materials, 4(1), 2–2.
Source: Crossref
Added: December 31, 2020
2015 journal article
Nanocomposites: Sweet Substrate: A Polysaccharide Nanocomposite for Conformal Electronic Decals (Adv. Mater. 9/2015)
Advanced Materials, 27(9), 1636–1636.
Source: Crossref
Added: February 24, 2020
2014 journal article
3D hydrodynamic focusing microfluidics for emerging sensing technologies
Biosensors and Bioelectronics, 67, 25–34.
author keywords: Microfluidics; Sensors; Hydrodynamic focusing; Flow cytometry; Microfluidic fabrication
MeSH headings : Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Cell Separation; Flow Cytometry; Hydrodynamics; Microfluidics
TL;DR:
The underlying principles for hydrodynamic focusing in three dimensions (3D) using miscible fluids and the application of these principles for creation of bios Sensors, separation of cells and particles for sample manipulation, and fabrication of materials that could be used for biosensors are explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science
Added: August 6, 2018
2014 journal article
Microfluidic Strategies for Design and Assembly of Microfibers and Nanofibers with Tissue Engineering and Regenerative Medicine Applications
Advanced Healthcare Materials, 4(1), 11–28.
MeSH headings : Animals; Humans; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods; Microfluidic Analytical Techniques / trends; Microfluidics / methods; Microfluidics / trends; Portraits as Topic
TL;DR:
This Progress Report summarizes advanced microfluidic methods for the fabrication of both microscale and nanoscale fibers and illustrates how different methods are enabling new biomedical applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2014 journal article
Microfluidic fabrication of multiaxial microvessels via hydrodynamic shaping
RSC Adv., 4(45), 23440–23446.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science
Added: August 6, 2018
2014 journal article
Platinum-Paper Micromotors: An Urchin-like Nanohybrid Catalyst for Green Monopropellant Bubble-Thrusters
ACS Applied Materials & Interfaces, 6(20), 17837–17847.
author keywords: nanowires; platinum; cellulose; propulsion; hydrogen peroxide; autonomous underwater vehicles (AUVs)
TL;DR:
The results demonstrate that these layered nanohybrid sheets are robust and catalytically effective for green, H2O2-based micro-AUV propulsion where the storage and handling of highly explosive, toxic fuels are prohibitive due to size-requirements, cost limitations, and close person-to-machine contact.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
Sweet Substrate: A Polysaccharide Nanocomposite for Conformal Electronic Decals
Advanced Materials, 27(9), 1600–1606.
MeSH headings : Electronics / instrumentation; Equipment Design; Glucans / chemistry; Materials Testing; Nanocomposites / chemistry; Plants; Polysaccharides / chemical synthesis; Polysaccharides / chemistry; Temperature
TL;DR:
A conformal electronic decal based on a polysaccharide circuit board (PCB) is fabricated and characterized, which is a bioactive material system for supporting electronic devices capable of conforming to bio-logical surfaces.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
Interpenetrating networks based on gelatin methacrylamide and PEG formed using concurrent thiol click chemistries for hydrogel tissue engineering scaffolds
Biomaterials, 35(6), 1845–1856.
author keywords: Interpenetrating network (IPN); Extracellular matrix; Thiol-yne; Click chemistry; Gelatin; Poly(ethylene glycol)
MeSH headings : Acrylamides / chemistry; Click Chemistry; Extracellular Matrix / chemistry; Gelatin / chemistry; Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Polyethylene Glycols / chemistry; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
The development of a bio/synthetic interpenetrating network (BioSINx), containing gelatin methacrylamide polymerized within a poly(ethylene glycol) (PEG) framework to form a mechanically robust network capable of supporting both internal cell encapsulation and surface cell adherence, leading to enhanced cytocompatibility for both cell adhesion and encapsulation.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
Microfabrication: Rapid and Continuous Hydrodynamically Controlled Fabrication of Biohybrid Microfibers (Adv. Funct. Mater. 6/2013)
Advanced Functional Materials, 23(6), 697–697.
Source: Crossref
Added: August 28, 2020
2013 journal article
Protein triggered fluorescence switching of near-infrared emitting nanoparticles for contrast-enhanced imaging
Journal of Materials Chemistry B, 1(36), 4542.
TL;DR:
This work presents a general approach for the synthesis of NIR emitting nanoparticles that exhibit a protein triggered activation/deactivation of the emission and offers a path to maximize the signal from the typically weak quantum yield inherent in NIR fluorophores.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Enzyme Recognition: Substrate-Baited Nanoparticles: A Catch and Release Strategy for Enzyme Recognition and Harvesting (Small 13/2012)
Small, 8(13), 1961–1961.
Source: Crossref
Added: August 28, 2020
2012 journal article
Magnetic Nanoclusters Exhibiting Protein-Activated Near-Infrared Fluorescence
ACS Nano, 7(1), 203–213.
author keywords: biomedical imaging; magnetic colloid; click chemistry; biodetection
MeSH headings : Fluorescence; Magnetite Nanoparticles / chemistry; Materials Testing; Proteins / chemistry; Spectroscopy, Near-Infrared / methods
TL;DR:
A route for producing magnetic nanoclusters with alkyne surface functionality that can be utilized as multimodal imaging probes and an effective "turn-on" of NIR emission is reported.
(via Semantic Scholar)
Source: Crossref
Added: December 31, 2020
2012 journal article
Rapid and Continuous Hydrodynamically Controlled Fabrication of Biohybrid Microfibers
Advanced Functional Materials, 23(6), 698–704.
author keywords: cell encapsulation; microfiber extrusion; hydrogel; microfabrication; hydrodynamic focusing
TL;DR:
Production of the fibers containing viable bacteria was continuous in contrast to the more typical methods in which cells infiltrated or were attached to prepared fibers, and the biohybrid fibers showed even distribution of encapsulated cells and >90% cell viability.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Substrate-Baited Nanoparticles: A Catch and Release Strategy for Enzyme Recognition and Harvesting
Small, 8(13), 2083–2090.
author keywords: nanoparticles; biological activity; enzyme-substrates; click chemistry; protein purification
MeSH headings : Click Chemistry / methods; Enzymes / chemistry; Enzymes / isolation & purification; Enzymes / metabolism; Nanoparticles / chemistry; Nanotechnology / methods
TL;DR:
The results establish a universal model applicable to concentrating and extracting known substrate-protein pairs, but it can be an invaluable tool in recognizing unknown protein-ligand affinities.
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Added: August 28, 2020
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