Michaela Copp

College of Engineering

Works (3)

Updated: August 7th, 2023 21:16

2022 article

Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes with aging and osteoarthritis

Copp, M. E., Chubinskaya, S., Bracey, D. N., Shine, J., Sessions, G., Loeser, R. F., & Diekman, B. O. (2022, August 22). AGING CELL.

By: M. Copp n, S. Chubinskaya *, D. Bracey *, J. Shine *, G. Sessions *, R. Loeser *, B. Diekman n

author keywords: arthritis; cartilage; single-cell gel electrophoresis
MeSH headings : Adult; Aged; Aging / genetics; Cadaver; Cartilage, Articular / metabolism; Cells, Cultured; Chondrocytes / metabolism; Comet Assay; DNA Damage / genetics; Humans; Middle Aged; Osteoarthritis / genetics; Osteoarthritis / metabolism
TL;DR: This study supports the investigation of mechanisms by which hypo‐replicative cell types accumulate high levels of damage in chondrocytes obtained from cadaveric donors of a wide age range and shows that most of the accumulated damage is in the form of strand breaks as opposed to alkali‐labile base damage. (via Semantic Scholar)
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Source: Web Of Science
Added: September 6, 2022

2021 journal article

The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence

OSTEOARTHRITIS AND CARTILAGE, 29(3), 402–412.

By: M. Copp n, M. Flanders  n, R. Gagliardi n, J. Gilbertie n, G. Sessions *, S. Chubinskaya*, R. Loeser *, L. Schnabel n , B. Diekman n

author keywords: SA-beta-gal; DNA damage; Osteoarthritis; Aging; TGF- beta 1; bFGF
MeSH headings : Animals; Ankle Joint; Cartilage, Articular / cytology; Cartilage, Articular / drug effects; Cartilage, Articular / metabolism; Cellular Senescence / drug effects; Cellular Senescence / genetics; Chemokine CCL2 / drug effects; Chemokine CCL2 / genetics; Chondrocytes / drug effects; Chondrocytes / metabolism; Cyclin-Dependent Kinase Inhibitor p16 / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; DNA Damage / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Histones / drug effects; Histones / metabolism; Horses; Humans; In Vitro Techniques; Inflammation / genetics; Insulin-Like Growth Factor Binding Protein 3 / drug effects; Insulin-Like Growth Factor Binding Protein 3 / genetics; Interleukin-6 / genetics; Matrix Metalloproteinase 13 / drug effects; Matrix Metalloproteinase 13 / genetics; Mitogens / pharmacology; Stifle; Transforming Growth Factor beta1 / pharmacology; beta-Galactosidase / drug effects; beta-Galactosidase / metabolism
TL;DR: Treatment of cartilage explants with mitogenic stimuli in the context of cellular damage reliably induces high levels of SA-β-gal activity and other senescence markers, which provides a physiologically relevant model system to investigate the mechanisms of senescences induction. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 29, 2021

2019 article

CONTROLLED INDUCTION AND TARGETED ELIMINATION OF P16(INK4A)-HIGH CHONDROCYTES TO INVESTIGATE SENESCENCE-MEDIATED CARTILAGE DYSFUNCTION

Sessions, G. A., Sinkler, M. A., Copp, M. E., & Diekman, B. O. (2019, April). OSTEOARTHRITIS AND CARTILAGE, Vol. 27, pp. S97–S97.

By: G. Sessions *, M. Sinkler *, M. Copp n & B. Diekman  n

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Source: Web Of Science
Added: April 20, 2020

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