Meghan Elizabeth Rebuli

Works (7)

Updated: July 5th, 2023 15:45

2017 article

Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats

Baldwin, K. R., Phillips, A. L., Horman, B., Arambula, S. E., Rebuli, M. E., Stapleton, H. M., & Patisaul, H. B. (2017, July 27). Scientific Reports, Vol. 7.

By: K. Baldwin n, A. Phillips *, B. Horman n, S. Arambula n, M. Rebuli n, H. Stapleton *, H. Patisaul n 

MeSH headings : Age Factors; Analysis of Variance; Animals; Behavior, Animal / drug effects; Dose-Response Relationship, Drug; Female; Flame Retardants / adverse effects; Flame Retardants / analysis; Male; Molecular Structure; Placenta / drug effects; Placenta / metabolism; Pregnancy; Rats; Rats, Wistar; Sex Factors
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Toxic Organic Pollutants Impact; Air Quality and Health Impacts
TL;DR: It is demonstrated that environmental chemicals may sex-dependently accumulate in the placenta, and that sex-biased exposure might translate to sex-specific adverse outcomes such as behavioral deficits. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 article

Interaction of bisphenol A (BPA) and soy phytoestrogens on sexually dimorphic sociosexual behaviors in male and female rats

Hicks, K. D., Sullivan, A. W., Cao, J., Sluzas, E., Rebuli, M., & Patisaul, H. B. (2016, July 2). Hormones and Behavior, Vol. 84, pp. 121–126.

By: K. Hicks n, A. Sullivan n, J. Cao n, E. Sluzas n, M. Rebuli n & H. Patisaul n 

author keywords: Endocrine disruption; Neuroendocrine disruption; Neuropeptides; Social; Diet; Open field; Affiliation; Activity; Environment
MeSH headings : Animals; Benzhydryl Compounds / pharmacology; Endocrine Disruptors / pharmacology; Exploratory Behavior / drug effects; Female; Isoflavones / pharmacology; Male; Phenols / pharmacology; Phytoestrogens / pharmacology; Rats; Sexual Behavior, Animal / drug effects; Social Behavior
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Early Childhood Education and Development; Estrogen and related hormone effects
TL;DR: Testing the individual and combined effects of low dose oral BPA and soy diet or the individual isoflavone genistein on rat sociosexual behaviors with the hypothesis that soy would obfuscate any BPA-related effects reinforces that environmental factors can shape complex behaviors and even reverse expected sex differences. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 article

Sex differences in microglial colonization and vulnerabilities to endocrine disruption in the social brain

Rebuli, M. E., Gibson, P., Rhodes, C. L., Cushing, B. S., & Patisaul, H. B. (2016, April 22). General and Comparative Endocrinology, Vol. 238, pp. 39–46.

By: M. Rebuli n, P. Gibson  n, C. Rhodes n, B. Cushing * & H. Patisaul n 

author keywords: Vole; Rat; Hypothalamus; EDC; Sexual differentiation; Puberty
MeSH headings : Amygdala / cytology; Amygdala / drug effects; Animals; Animals, Newborn; Arvicolinae; Benzhydryl Compounds / toxicity; Brain / cytology; Brain / drug effects; Brain / growth & development; Dentate Gyrus / cytology; Dentate Gyrus / drug effects; Endocrine Disruptors / toxicity; Female; Male; Microglia / drug effects; Microglia / metabolism; Phenols / toxicity; Rats, Wistar; Sex Characteristics; Social Behavior; Somatosensory Cortex / cytology; Somatosensory Cortex / drug effects
topics (OpenAlex): Neuroinflammation and Neurodegeneration Mechanisms; Neuroendocrine regulation and behavior; Estrogen and related hormone effects
TL;DR: This work is the first to observe that developmental exposure to the synthetic estrogen ethinyl estradiol (EE) or BPA alters the sex-specific colonization of the hippocampus and amygdala by microglia. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 article

Assessment of sex specific endocrine disrupting effects in the prenatal and pre-pubertal rodent brain

Rebuli, M. E., & Patisaul, H. B. (2015, August 22). The Journal of Steroid Biochemistry and Molecular Biology, Vol. 160, pp. 148–159.

By: M. Rebuli n & H. Patisaul n 

author keywords: Endocrine disrupting compounds; Neurodevelopment; Sex differences; Developmental exposure; Rodent; Bisphenol; BPA; Genistein; Xenoestrogen; EDC
MeSH headings : Animals; Brain / drug effects; Brain / embryology; Brain / growth & development; Endocrine Disruptors / pharmacology; Female; Male; Puberty / drug effects; Rodentia / embryology; Rodentia / growth & development; Sex Characteristics
topics (OpenAlex): Birth, Development, and Health; Estrogen and related hormone effects; Maternal Mental Health During Pregnancy and Postpartum
TL;DR: The developmental EDC exposure literature demonstrates evidence of altered neurodevelopment as early as fetal life, with sex specific effects observed throughout the brain even before puberty. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 article

Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study

Rebuli, M. E., Camacho, L., Adonay, M. E., Reif, D. M., Aylor, D. L., & Patisaul, H. B. (2015, July 23). Toxicological Sciences, Vol. 148, pp. 341–354.

By: M. Rebuli n, L. Camacho *, M. Adonay n, D. Reif n , D. Aylor n  & H. Patisaul n 

Contributors: M. Rebuli n, L. Camacho *, M. Adonay n, D. Reif n , D. Aylor n  & H. Patisaul n 

author keywords: bisphenol A; CLARITY; behavior; anxiety; exploratory activity; endocrine disruption; EDC; sexually dimorphic; brain; BPA; plastic
MeSH headings : Age Factors; Animals; Anxiety / chemically induced; Anxiety / psychology; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Exploratory Behavior / drug effects; Female; Gestational Age; Lactation; Male; Maternal Exposure / adverse effects; Motor Activity / drug effects; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / psychology; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Risk Assessment; Sex Factors
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals
TL;DR: No consistent effects of BPA were observed for any endpoint, in either sex, at either age compared to vehicle controls; however, significant differences between BPA-exposed and ethinyl estradiol-exp exposed groups were identified for some endpoints. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 article

Investigation of the Effects of Subchronic Low Dose Oral Exposure to Bisphenol A (BPA) and Ethinyl Estradiol (EE) on Estrogen Receptor Expression in the Juvenile and Adult Female Rat Hypothalamus

Rebuli, M. E., Cao, J., Sluzas, E., Delclos, K. B., Camacho, L., Lewis, S. M., … Patisaul, H. B. (2014, April 20). Toxicological Sciences, Vol. 140, pp. 190–203.

By: M. Rebuli n, J. Cao n, E. Sluzas n, K. Delclos *, L. Camacho *, S. Lewis *, M. Vanlandingham*, H. Patisaul n 

author keywords: brain; endocrine disruptor; endocrine disruption; hypothalamus; development; subchronic exposure; sexually dimorphic; ethinyl estradiol; bisphenol A
MeSH headings : Aging / metabolism; Animals; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Estrogen Receptor alpha / genetics; Estrogen Receptor beta / genetics; Ethinyl Estradiol / toxicity; Female; Gene Expression / drug effects; Hypothalamus / drug effects; Hypothalamus / embryology; Hypothalamus / growth & development; Hypothalamus / metabolism; Male; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / metabolism; Rats, Sprague-Dawley; Receptors, Estrogen / genetics; Sex Characteristics
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Estrogen and related hormone effects
TL;DR: The impact of subchronic exposure from gestation to adulthood to oral doses of BPA below the current no-observed-adverse-effect level (NOAEL) of 5 mg/kg body weight (bw)/day on estrogen receptor (ESR) expression in sexually dimorphic brain regions of prepubertal and adult female rats is examined. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 article

Anxiogenic Effects of Developmental Bisphenol A Exposure Are Associated with Gene Expression Changes in the Juvenile Rat Amygdala and Mitigated by Soy

Patisaul, H. B., Sullivan, A. W., Radford, M. E., Walker, D. M., Adewale, H. B., Winnik, B., … Gore, A. C. (2012, September 5). PLoS ONE, Vol. 7.

By: H. Patisaul n , A. Sullivan n, M. Radford n, D. Walker *, H. Adewale n, B. Winnik*, J. Coughlin*, B. Buckley *, A. Gore *

MeSH headings : Amygdala / drug effects; Animals; Anxiety / chemically induced; Anxiety / etiology; Benzhydryl Compounds / adverse effects; Estrogen Receptor beta / metabolism; Female; Gene Expression Profiling; Genistein / pharmacology; Maternal Exposure; Phenols / adverse effects; Pregnancy; Pregnancy, Animal; Rats; Rats, Wistar; Receptors, Melanocortin / metabolism; Sex Characteristics; Soybeans / drug effects; Water / chemistry
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Early Childhood Education and Development; Nutrition, Genetics, and Disease
TL;DR: Results show that behavioral impacts of BPA can manifest during adolescence, but wane in adulthood, and may be mitigated by diet, and reveal that, because ERβ and melanocortin receptors are crucial to their function, oxytocin/vasopressin signaling pathways, which have been linked to human affective disorders, may underlie these behavioral outcomes. (via Semantic Scholar)
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6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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