Works (166)

Updated: April 5th, 2024 09:30

2024 article

Genotype and ripening method affect carotenoid content and bio-accessibility in banana

Munoz, B., Hayes, M., Perkins-Veazie, P., Gillitt, N., Munoz, M., Kay, C. D., … Iorizzo, M. (2024, March 4). FOOD & FUNCTION, Vol. 3.

By: B. Munoz n, M. Hayes n, P. Perkins-Veazie n, N. Gillitt, M. Munoz, C. Kay n, M. Lila n, M. Ferruzzi n, M. Iorizzo n

Sources: Web Of Science, ORCID
Added: March 8, 2024

2023 journal article

Compositional analysis of phytochemicals and polysaccharides from Senegalese plant ingredients: Adansonia digitata (baobab), Moringa oleifera (moringa) and Hibsicus sabdariffa (hibiscus)

NFS JOURNAL, 32.

By: H. Debelo n, C. Fiecke*, A. Terekhov*, B. Reuhs*, B. Hamaker* & M. Ferruzzi n

author keywords: Nutrition profile; Phenolic compounds; Monosaccharide composition; Moringa; Hibiscus; Baobab
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 7, 2023

2023 journal article

Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries

ANTIOXIDANTS, 12(5).

By: C. Weaver*, M. Ferruzzi*, M. Maiz*, D. Cladis*, C. Nakatsu*, G. McCabe*, M. Lila n

author keywords: blueberries; polyphenols; anthocyanins; precision nutrition
Sources: Web Of Science, ORCID
Added: May 24, 2023

2023 journal article

Formation of cereal protein disulfide-linked stable matrices by apigeninidin, a 3-deoxyanthocyanidin

FOOD CHEMISTRY, 404.

By: L. Schmidt*, O. Ozturk*, J. Young*, B. Bugusu*, M. Li n, D. Claddis*, Z. Mohamedshah n, M. Ferruzzi n, B. Hamaker*

author keywords: Food matrix; 3-deoxyanthocyanidin; Apigeninidin; Starch digestion
MeSH headings : Edible Grain / chemistry; Disulfides / analysis; Anthocyanins / analysis; Sorghum / chemistry; Starch / metabolism; Zea mays / metabolism; Digestion; Animal Feed / analysis
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: November 28, 2022

2023 journal article

Mechanism of off-color formation in potato chips fried in oil systems containing ascorbic acid as a stabilizer

LWT-FOOD SCIENCE AND TECHNOLOGY, 179.

By: L. Iglesias-Carres n, K. Racine n, S. Chadwick n, C. Nunn n, S. Kalambur*, A. Neilson n, M. Ferruzzi*

author keywords: Amino acid; Maillard reaction; BHT; Rosemary; Carnosic acid; Tocopherol; Moisture; Solubility; Citric acid; Canola oil
Sources: Web Of Science, ORCID
Added: June 12, 2023

2023 journal article

Mixed Berry Juice and Cellulose Fiber Have Differential Effects on Peripheral Blood Mononuclear Cell Respiration in Overweight Adults

NUTRIENTS, 15(7).

By: P. Solverson*, G. Albaugh*, H. Debelo n, M. Ferruzzi n, D. Baer* & J. Novotny*

author keywords: anthocyanins; flavonoids; cellulose; fiber; oxygraph; mitochondria; cellular respiration
MeSH headings : Humans; Adult; Fruit; Overweight; Anthocyanins / pharmacology; Cellulose / pharmacology; Leukocytes, Mononuclear; Gelatin; Obesity; Respiration
TL;DR: Different components of berries, specifically anthocyanins/flavonoids and fiber, appear to have differential effects on cellular respiration, with the greatest differences being between the pressed berry juice and the fiber-enriched gelatin. (via Semantic Scholar)
Source: Web Of Science
Added: May 1, 2023

2023 journal article

Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial

AMERICAN JOURNAL OF CLINICAL NUTRITION, 118(2), 382–390.

By: J. Hodges*, M. Maiz*, S. Cao*, P. Lachcik*, M. Peacock*, G. McCabe*, L. McCabe*, D. Cladis* ...

author keywords: bone; blueberries; calcium; osteoporosis; polyphenols; postmenopausal
TL;DR: Moderate consumption of blueberries may be an effective strategy to attenuate bone loss in healthy postmenopausal women and no significant relationships were found between bone resorption biomarkers, 25-hydroxyvitamin D, and interventions. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: September 5, 2023

2023 journal article

Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson's Disease

ANTIOXIDANTS, 12(7).

By: M. Tambe*, A. Jacquet*, K. Strathearn*, J. Hensel*, B. Colon*, A. Chandran*, G. Yousef n, M. Grace n ...

author keywords: anthocyanin; Nrf2; paraquat; Parkinson's disease; polyphenols; rotenone
TL;DR: It is suggested that extracts enriched with certain combinations of ANC, PAC, stilbenes, and other polyphenols could potentially slow neurodegeneration in the brains of individuals exposed to PQ or rotenone by activating cellular antioxidant mechanisms and/or alleviating mitochondrial dysfunction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: July 25, 2023

2023 article

Trait stacking simultaneously enhances provitamin A carotenoid and mineral bioaccessibility in biofortified Sorghum bicolor

Dzakovich, M. P., Debelo, H., Albertsen, M. C., Che, P., Jones, T. J., Simon, M. K., … Ferruzzi, M. G. (2023, July 14). FOOD & FUNCTION.

By: M. Dzakovich n, H. Debelo n, M. Albertsen*, P. Che*, T. Jones*, M. Simon*, Z. Zhao*, K. Glassman*, M. Ferruzzi n

MeSH headings : Child; Female; Humans; Child, Preschool; Provitamins / metabolism; Sorghum / chemistry; Vitamin A / metabolism; Phytic Acid / metabolism; 6-Phytase / genetics; 6-Phytase / metabolism; Carotenoids / metabolism; Minerals / metabolism; Iron / metabolism; Zinc / metabolism
Source: Web Of Science
Added: July 31, 2023

2022 article

Bioaccessibility and intestinal cell uptake of carotenoids and chlorophylls differ in powdered spinach by the ingredient form as measured using in vitro gastrointestinal digestion and anaerobic fecal fermentation models

Hayes, M., Mohamedshah, Z., Chadwick-Corbin, S., Hoskin, R., Iorizzo, M., Lila, M. A., … Ferruzzi, M. G. (2022, March 8). FOOD & FUNCTION, Vol. 13.

By: M. Hayes n, Z. Mohamedshah n, S. Chadwick-Corbin n, R. Hoskin n, M. Iorizzo n, M. Lila n, A. Neilson n, M. Ferruzzi n

MeSH headings : Anaerobiosis; Caco-2 Cells; Carotenoids / metabolism; Chlorophyll; Digestion; Fermentation; Health Promotion; Humans; Powders; Spinacia oleracea / metabolism
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: March 31, 2022

2022 article

Bioaccessibility, gut microbial metabolism and intestinal transport of phenolics from 100% Concord grape juice and whole grapes are similar in a simulated digestion and fecal fermentation model

Mohamedshah, Z., Hayes, M., Chadwick-Corbin, S., Neilson, A. P., & Ferruzzi, M. G. (2022, March 9). FOOD & FUNCTION, Vol. 3.

By: Z. Mohamedshah n, M. Hayes n, S. Chadwick-Corbin n, A. Neilson n & M. Ferruzzi n

MeSH headings : Caco-2 Cells; Digestion; Fermentation; Fruit / chemistry; Gastrointestinal Microbiome; Humans; Phenols / analysis; Vitis / metabolism
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: April 4, 2022

2022 article

Boosting the Bioaccessibility of Dietary Bioactives by Delivery as Protein-Polyphenol Aggregate Particles

Lila, M. A., Hoskin, R. T., Grace, M. H., Xiong, J., Strauch, R., Ferruzzi, M., … Kay, C. (2022, April 8). JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, Vol. 4.

By: M. Lila n, R. Hoskin n, M. Grace n, J. Xiong n, R. Strauch n, M. Ferruzzi*, M. Iorizzo n, C. Kay n

author keywords: bioavailability; digestion; absorption; circulation; uptake; matrix
MeSH headings : Humans; Polyphenols / analysis; Fruit / chemistry; Protein Aggregates; Dietary Proteins; Biological Availability; Food Ingredients
TL;DR: Evidence to date suggests that complexation of phy toactive polyphenolics effectively enhances their health-relevant impacts, specifically because the phytoactives are protected in the protein matrix during transit in the GIT, allowing intact, non-degraded molecules to reach the colon for catabolism at the gut microbiome level. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: April 14, 2022

2022 journal article

Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: A pilot study

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 626, 205–210.

By: K. Racine*, L. Iglesias-Carres, J. Herring, M. Ferruzzi*, C. Kay*, J. Tessem, A. Neilson*

author keywords: BTBR; Ob/ob; Type-2 diabetes; Flavanol; Insulin; Beta cell
MeSH headings : Animals; Cacao; Diabetes Mellitus, Type 2 / drug therapy; Female; Humans; Hyperglycemia; Hyperinsulinism; Male; Mice; Obesity; Pilot Projects; Plant Extracts / pharmacology; Plant Extracts / therapeutic use
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: October 17, 2022

2022 journal article

Dissecting the genetic basis of bioactive metabolites and fruit quality traits in blueberries (Vaccinium corymbosum L.)

FRONTIERS IN PLANT SCIENCE, 13.

By: M. Mengist n, M. Grace n, T. Mackey*, B. Munoz n, B. Pucker*, N. Bassil*, C. Luby*, M. Ferruzzi n, M. Lila n, M. Iorizzo n

author keywords: blueberry; anthocyanin; acylation; glycosylation; QTL mapping; candidate genes; fruit quality; chlorogenic acid
TL;DR: The study provides the first insights into the genetic basis controlling anthocyanins accumulation and composition, chlorogenic acid and fruit quality traits, and establishes a framework to advance genetic studies and molecular breeding for anthcyanins in blueberry. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: September 26, 2022

2022 article

Estimation of nutritional postharvest losses along food value chains: A case study of three key food security commodities in sub-Saharan Africa

Bechoff, A., Shee, A., Mvumi, B. M., Ngwenyama, P., Debelo, H., Ferruzzi, M. G., … Tomlins, K. I. (2022, February 4). FOOD SECURITY.

author keywords: Postharvest nutrient loss; Postharvest loss; Food system; Human nutritional requirements; Nutrient loss prediction
Source: Web Of Science
Added: February 21, 2022

2022 journal article

Potential of moringa leaf and baobab fruit food-to-food fortification of wholegrain maize porridge to improve iron and zinc bioaccessibility

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 73(1), 15–27.

By: O. Adetola*, J. Kruger*, M. Ferruzzi n, B. Hamaker* & J. Taylor*

author keywords: Adansonia digitata; iron bioavailability; mineral fortification; Moringa oleifera; wholegrain
MeSH headings : Adansonia; Food, Fortified; Fruit; Iron; Moringa; Plant Leaves; Zea mays; Zinc
TL;DR: While moringa FtFF could be inhibitory to iron and zinc bioavailability in cereal-based porridges, baobab fruit FtFFcould improve their bioavailability, especially in combination with conventional iron fortification. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: May 17, 2021

2022 article

Prune supplementation for 12 months alters the gut microbiome in postmenopausal women

Simpson, A. M. R., De Souza, M. J., Damani, J., Rogers, C., Williams, N. I., Weaver, C., … Nakatsu, C. H. (2022, November 7). FOOD & FUNCTION, Vol. 11.

MeSH headings : Humans; Female; Middle Aged; Aged; Gastrointestinal Microbiome; RNA, Ribosomal, 16S / genetics; Postmenopause; Feces / microbiology; Bacteria; Dietary Supplements
TL;DR: Differing gut microbiomes and correlation of some taxa with select phenolic metabolites and inflammatory markers, particularly Lachnospiraceae, after prune consumption suggest a potential mechanism mediating health effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: November 28, 2022

2022 journal article

Spray-dried and freeze-dried protein-spinach particles; effect of drying technique and protein type on the bioaccessibility of carotenoids, chlorophylls, and phenolics

FOOD CHEMISTRY, 388.

By: M. Grace n, R. Hoskin n, M. Hayes n, M. Iorizzo n, C. Kay n, M. Ferruzzi n, M. Lila n

author keywords: Spinach phytochemicals; Whey protein; Soy protein; Drying; In vitro digestion; Dried ingredients
MeSH headings : Carotenoids / metabolism; Chlorophyll / metabolism; Digestion; Excipients / metabolism; Flavonoids / metabolism; Freeze Drying; Phenols / metabolism; Spinacia oleracea / metabolism
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: June 13, 2022

2022 journal article

Structural requirements of flavonoids for the selective inhibition of alpha-amylase versus alpha-glucosidase

FOOD CHEMISTRY, 370.

By: J. Lim*, M. Ferruzzi n & B. Hamaker*

author keywords: Flavonoids structure; Protein structure; Endo-type alpha-amylase; Exo-type alpha-glucosidase; Selective inhibition
MeSH headings : Flavonoids; Humans; Starch; alpha-Amylases; alpha-Glucosidases
TL;DR: In the present study, 14 structurally unique flavonoids were screened to systematically investigate structural requirements for selectively inhibiting human α-amylase versus α-glucosidase to obtain a slow but complete starch digestion for health benefit. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 12, 2021

2021 article

(Poly)phenol toxicity in vivo following oral administration: A targeted narrative review of (poly)phenols from green tea, grape, and anthocyanin-rich extracts

Cladis, D. P., Weaver, C. M., & Ferruzzi, M. G. (2021, November 2). PHYTOTHERAPY RESEARCH.

By: D. Cladis*, C. Weaver* & M. Ferruzzi n

author keywords: (poly)phenol toxicity; dietary supplements; hormesis
MeSH headings : Administration, Oral; Anthocyanins / toxicity; Humans; Phenol; Phenols / toxicity; Plant Extracts / toxicity; Polyphenols; Tea; Vitis
TL;DR: There is limited evidence of overt toxicity from oral ingestion of these (poly)phenol‐rich sources, though more research on the safety of high doses—as well as defining what constitutes a “high” dose of both individual and complex mixtures of ( poly)phenols—is needed before these observations can be used to create dietary guidance for consumers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 15, 2021

2021 journal article

Caryocar brasiliense Camb. fruits from the Brazilian Cerrado as a rich source of carotenoids with pro-vitamin A activity

JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 101.

By: K. Geocze*, L. Barbosa*, C. Lima*, M. Ferruzzi n, P. Fidencio*, H. Sant'ana*, F. Silverio*

author keywords: Pequi; Cerrado fruits; Carotenoids; beta-carotene; Pro-vitamin A carotenoids; Principal Components Analysis
TL;DR: The vitamin A value expressed as μg Retinol Activity Equivalent (RAE) in the fresh fruit and carotenoid profile were determined by high-performance liquid chromatography coupled to a diode array detector (HPLC- DAD), and the mainCarotenoids found were β-cryptoxanthin and β-carotene. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: July 6, 2021

2021 journal article

Chemical, Manufacturing, and Standardization Controls of Grape Polyphenol Dietary Supplements in Support of a Clinical Study: Mass Uniformity, Polyphenol Dosage, and Profiles

FRONTIERS IN NUTRITION, 8.

By: W. Lyu*, D. Rodriguez, M. Ferruzzi n, G. Pasinetti*, J. Murrough*, J. Simon*, Q. Wu*

author keywords: botanicals; quality control; grape seed extract (GSE); resveratrol; grape juice; LC; UV-Vis; MS; product quality; authentication
TL;DR: The results indicate that the total identified polyphenol content in each grape seed extract (GSE) capsule/CGJ is very similar and all GSE/RSV capsules pass the content/weight uniformity test. (via Semantic Scholar)
Source: Web Of Science
Added: February 7, 2022

2021 journal article

Co-extruded wheat/okra composite blends result in soft, cohesive and resilient crumbs rich in health-promoting compounds

FOOD CHEMISTRY, 364.

author keywords: Okra; Phenolics; Dietary fiber; Extrusion; Wheat bread; Flavonols; Baking; Food structuring
MeSH headings : Abelmoschus; Bread; Flour; Hardness; Triticum
TL;DR: This work investigates the partial solubilization of cell wall polysaccharides in okra flours and the changes in the profile of free and bound phenolics through twin-screw extrusion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 30, 2021

2021 journal article

Design and Nutrient Analysis of a Carotenoid-Rich Food Product to Address Vitamin A and Protein Deficiency

FOODS, 10(5).

TL;DR: The results of this project indicate that the three ingredients can be combined into a single 250 g food product to provide >300 kcal energy, complete protein, and micronutrients in a more bioavailable form. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: June 10, 2021

2021 journal article

Dietary starch is weight reducing when distally digested in the small intestine

CARBOHYDRATE POLYMERS, 273.

By: J. Lim*, M. Ferruzzi n & B. Hamaker*

author keywords: Ileal starch digestion; alpha-Amylase; Inhibition; Glucagon-like peptide-1 (GLP-1); Gut-brain axis; Weight management
MeSH headings : Animals; Brain-Gut Axis / drug effects; Glucagon-Like Peptide 1 / metabolism; Glycoside Hydrolase Inhibitors / pharmacology; Ileum / drug effects; Ileum / enzymology; Ileum / metabolism; Luteolin / pharmacology; Male; Mice, Inbred C57BL; Postprandial Period; Quercetin / pharmacology; Starch / metabolism; Weight Loss / drug effects; alpha-Amylases / metabolism
TL;DR: It is shown how digestible starch and flavonoids can be used as a dietary approach to manage food intake and weight gain through elevation of glucagon-like peptide-1 (GLP-1) secretion for gut-brain axis communication. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 18, 2021

2021 journal article

Dissolution Study on Grape Polyphenol Hard Gelatin Capsule Dietary Supplements

FRONTIERS IN NUTRITION, 8.

By: W. Lyu*, T. Omar*, H. Patel*, D. Rodriguez, M. Ferruzzi n, G. Pasinetti*, J. Murrough*, F. Muzzio*, J. Simon*, Q. Wu*

author keywords: grape seed extract; resveratrol; UHPLC-QQQ; MS; polyphenol; bioavailability
TL;DR: Results showed that under a low pH of 1.2 (simulated stomach environment), bioactive compounds were released on time from the GSE capsules and met the USP guidelines; however, under a higher pH of 4.6 (simulating duodenum environment), the same biomarkers failed, suggesting the need to further improve the dissolution of GSE over a wider range of pH environments to enhance bioavailability and efficacy. (via Semantic Scholar)
Source: Web Of Science
Added: December 20, 2021

2021 article

Effects of Concord grape juice flavor intensity and phenolic compound content on glycemia, appetite and cognitive function in adults with excess body weight: a randomized double-blind crossover trial

Coelho, O. G. L., Alfenas, R. de C. G., Debelo, H., Wightman, J. L. D., Ferruzzi, M. G., & Mattes, R. D. (2021, October 18). FOOD & FUNCTION.

By: O. Coelho*, R. Alfenas*, H. Debelo n, J. Wightman*, M. Ferruzzi n & R. Mattes*

MeSH headings : Adult; Appetite / drug effects; Blood Glucose / drug effects; Cognition / drug effects; Cross-Over Studies; Double-Blind Method; Female; Fruit and Vegetable Juices; Humans; Male; Phenols / analysis; Phenols / pharmacology; Vitis
TL;DR: Both natural phenolics and flavor essence of CGJ may help to moderate appetite and glycemia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: November 8, 2021

2021 journal article

High-density linkage map construction and identification of loci regulating fruit quality traits in blueberry

HORTICULTURE RESEARCH, 8(1).

By: M. Mengist n, H. Bostan n, E. Young n, K. Kay*, N. Gillitt*, J. Ballington n, C. Kay n, M. Ferruzzi n ...

TL;DR: The genetic basis of fruit quality traits in blueberry was dissected and an association between these fruit quality trait and metabolites detected by Proton nuclear magnetic resonance analysis was established. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, ORCID
Added: August 1, 2021

2021 article

Influence of simulated food and oral processing on carotenoid and chlorophyll in vitro bioaccessibility among six spinach genotypes

Hayes, M., Corbin, S., Nunn, C., Pottorff, M., Kay, C. D., Lila, M. A., … Ferruzzi, M. G. (2021, May 14). FOOD & FUNCTION, Vol. 5.

By: M. Hayes n, S. Corbin*, C. Nunn*, M. Pottorff*, C. Kay n, M. Lila n, M. Iorrizo n, M. Ferruzzi n

MeSH headings : Biological Availability; Carotenoids / chemistry; Carotenoids / metabolism; Carotenoids / pharmacokinetics; Chlorophyll / chemistry; Chlorophyll / metabolism; Chlorophyll / pharmacokinetics; Digestion; Genotype; Models, Biological; Spinacia oleracea / chemistry; Spinacia oleracea / genetics
TL;DR: It is suggested that the genotype, processing treatment, and genotype × processing (G × P) interaction may affect carotenoid and chlorophyll bioaccessibility in spinach and that food processing remains a dominant factor in modulating the bioavailability of these phytochemicals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID
Added: June 22, 2021

2021 journal article

Measuring consumer acceptance of instant fortified millet products using affective tests and auctions in Dakar, Senegal

INTERNATIONAL FOOD AND AGRIBUSINESS MANAGEMENT REVIEW, 24(3), 499–522.

By: H. De Groote*, B. Munyua*, D. Traore*, J. Taylor*, M. Ferruzzi n, C. Ndiaye*, I. Onyeoziri*, B. Hamaker*

author keywords: extrusion; consumers; instant; food-to-food fortification; willingness-to-pay
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: June 10, 2021

2021 journal article

Skeletal Protection and Promotion of Microbiome Diversity by Dietary Boosting of the Endogenous Antioxidant Response

JOURNAL OF BONE AND MINERAL RESEARCH, 36(4), 768–778.

By: A. Sato*, G. Pellegrini*, M. Cregor*, K. McAndrews*, R. Choi*, M. Maiz*, O. Johnson*, L. McCabe* ...

author keywords: NUTRITION; GENETIC ANIMAL MODELS; SEX STEROIDS; OSTEOPOROSIS; THERAPEUTICS— OTHER
MeSH headings : Animals; Antioxidants; Bone and Bones; Diet; Female; Humans; Male; Mice; Microbiota; Phylogeny
TL;DR: A blueberry cultivar that added to the diet protects female mice from musculoskeletal loss and body weight changes induced by ovariectomy and elicits antioxidant defense responses independently of classical antioxidant/estrogenic signaling, and increases gut microbiome diversity toward a healthier signature. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: January 19, 2021

2021 journal article

Storage of biofortified maize in Purdue Improved Crop Storage (PICS) bags reduces disulfide linkage-driven decrease in porridge viscosity

LWT-FOOD SCIENCE AND TECHNOLOGY, 136.

By: S. Nkhata*, A. Liceaga*, T. Rocheford*, B. Hamaker* & M. Ferruzzi n

author keywords: Biofortified maize; Porridge; Viscosity; Purdue improved crops storage (PICS)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: January 11, 2021

2021 journal article

Targeted Phenolic Characterization and Antioxidant Bioactivity of Extracts from Edible Acheta domesticus

FOODS, 10(10).

By: M. Nino*, L. Reddivari*, M. Ferruzzi n & A. Liceaga*

author keywords: edible insects; phenolic compounds; antioxidant activity; bioactive compounds
TL;DR: The discovery of phenolic compounds in A. domesticus implies the ability of this insect species to sequester and absorb dietary phenolics leading to possible added health benefits when consumed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science; OpenAlex)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: November 15, 2021

2020 journal article

African Adansonia digitata fruit pulp (baobab) modifies provitamin A carotenoid bioaccessibility from composite pearl millet porridges

JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, 57(4), 1382–1392.

By: H. Debelo*, C. Ndiaye*, J. Kruger*, B. Hamaker* & M. Ferruzzi n

author keywords: Provitamin A carotenoids; Bioaccessibility; Baobab; Micronutrients; Fortification
TL;DR: The findings suggest that the inhibitory effects on carotenoid micellarization (bioaccessibility) observed with increased baobab addition may not ultimately limit the bioavailability of carotanoids. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: December 9, 2019

2020 review

Carrot Anthocyanins Genetics and Genomics: Status and Perspectives to Improve Its Application for the Food Colorant Industry

[Review of ]. GENES, 11(8).

By: M. Iorizzo n, J. Curaba n, M. Pottorff n, M. Ferruzzi n, P. Simon* & P. Cavagnaro*

author keywords: anthocyanins; carrots; natural colorant; genetics
MeSH headings : Anthocyanins / chemistry; Anthocyanins / metabolism; Biological Products / chemistry; Biological Products / metabolism; Chemical Phenomena; Daucus carota / classification; Daucus carota / genetics; Daucus carota / metabolism; Food Coloring Agents / chemistry; Food Coloring Agents / metabolism; Food Industry; Gene Expression Regulation, Plant; Genetic Association Studies; Genome, Plant; Genomics / methods; Pigmentation / genetics; Plant Proteins / genetics; Quantitative Trait, Heritable
TL;DR: A view of the current knowledge gaps and advancement needs as regards developing and applying innovative molecular tools to improve the yield, product performance and stability of carrot anthocyanin for use as a natural food colorant is provided. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: November 2, 2020

2020 journal article

Comparative assessment of phenolic bioaccessibility from 100% grape juice and whole grapes

FOOD & FUNCTION, 11(7), 6433–6445.

By: Z. Mohamedshah n, S. Chadwick-Corbin n, J. Wightman* & M. Ferruzzi n

MeSH headings : Anthocyanins / analysis; Anthocyanins / pharmacokinetics; Biological Availability; Flavonoids / analysis; Flavonoids / pharmacokinetics; Flavonols / analysis; Flavonols / pharmacokinetics; Fruit / chemistry; Fruit and Vegetable Juices / analysis; Hydroxybenzoates / analysis; Hydroxybenzoates / pharmacokinetics; Phenols / pharmacokinetics; Seeds / chemistry; Species Specificity; Stilbenes / analysis; Stilbenes / pharmacokinetics; Vitis
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 10, 2020

2020 journal article

Consumer Acceptance and Willingness to Pay for Instant Cereal Products With Food-to-Food Fortification in Eldoret, Kenya

FOOD AND NUTRITION BULLETIN, 41(2), 224–243.

By: H. De Groote*, V. Mugalavai*, M. Ferruzzi n, A. Onkware*, E. Ayua*, K. Duodu*, M. Ndegwa*, B. Hamaker*

author keywords: consumers; maize; sorghum; instant; Africa; fortified flour; cereals
MeSH headings : Adult; Consumer Behavior; Female; Food Handling; Food, Fortified / economics; Humans; Kenya; Male; Socioeconomic Factors; Zea mays
TL;DR: There is a potential market for improved cereal products in Kenya, but more for uji than for ugali, especially with instant, mixed, and whole flour. (via Semantic Scholar)
Source: Web Of Science
Added: April 20, 2020

2020 journal article

Development of a genetic framework to improve the efficiency of bioactive delivery from blueberry

SCIENTIFIC REPORTS, 10(1).

By: M. Mengist n, H. Burtch n, H. Debelo n, M. Pottorff n, H. Bostan n, C. Nunn n, S. Corbin n, C. Kay n ...

MeSH headings : Blueberry Plants / genetics; Blueberry Plants / metabolism; Digestion; Flavonoids / metabolism; Genotype; Hydroxybenzoates / metabolism; In Vitro Techniques
Sources: Web Of Science, ORCID
Added: November 16, 2020

2020 review

Dose-Response Relation between Tea Consumption and Risk of Cardiovascular Disease and All-Cause Mortality: A Systematic Review and Meta-Analysis of Population-Based Studies

[Review of ]. ADVANCES IN NUTRITION, 11(4), 790–814.

author keywords: tea; Camellia sinensis; cardiovascular disease; all cause mortality; systematic review
MeSH headings : Adult; Aged; Cardiovascular Diseases / prevention & control; Cause of Death; Humans; Prospective Studies; Stroke; Tea
TL;DR: Daily tea intake as part of a healthy habitual dietary pattern may be associated with lower risks of CVD and all-cause mortality among adults. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: December 14, 2020

2020 journal article

Effect of edible plant materials on provitamin A stability and bioaccessibility from extruded whole pearl millet (P. typhoides) composite blends

LWT-FOOD SCIENCE AND TECHNOLOGY, 123.

By: C. Ndiaye*, M. Martinez*, B. Hamaker*, O. Campanella* & M. Ferruzzi n

author keywords: Pearl millet; African plants; Extrusion; Provitamin A; Bioaccessibility; Starch digestion
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: April 27, 2020

2020 journal article

Feasibility of Mass-Spectrometry to Lower Cost and Blood Volume Requirements for Assessment of B Vitamins in Patients Undergoing Bariatric Surgery

METABOLITES, 10(6).

By: S. Armah*, M. Ferruzzi n & N. Gletsu-Miller*

author keywords: B vitamin complex; nutrition assessment; analytical chemistry techniques
TL;DR: The feasibility of the HPLC–MS/MS method for use in patients who undergo bariatric surgery is demonstrated by analyzing pooled plasma from patients with a lower cost and blood volume than had they sent the samples to a commercial laboratory. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 10, 2020

2020 journal article

Formulation of Orange Juice with Dietary Fibers Enhances Bioaccessibility of Orange Flavonoids in Juice but Limits Their Ability to Inhibit In Vitro Glucose Transport

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68(35), 9387–9397.

By: S. Moser*, J. Shin*, P. Kasturi*, B. Hamaker*, M. Ferruzzi n & N. Bordenave*

author keywords: citrus; pomace; pectin; dietary fiber; polyphenol; glucose transport; modeling
MeSH headings : Biological Transport; Caco-2 Cells; Citrus sinensis / chemistry; Citrus sinensis / metabolism; Dietary Fiber / analysis; Dietary Fiber / metabolism; Flavonoids / metabolism; Fruit / chemistry; Fruit / metabolism; Fruit and Vegetable Juices / analysis; Glucose / metabolism; Humans
TL;DR: The effect of formulating orange juice with dietary fiber (DF) on in vitro bioaccessibility of flavonoids and their ability to inhibit glucose transport in Caco-2 cells were investigated on Valencia orange fruit, orange juice (OJ) and OJ formulated with 1% and 2.8% DF. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 5, 2020

2020 journal article

Improving natural product research translation: From source to clinical trial

FASEB JOURNAL, 34(1), 41–65.

By: B. Sorkin*, A. Kuszak*, G. Bloss*, N. Fukagawa*, F. Hoffman, M. Jafari*, B. Barrett*, P. Brown* ...

author keywords: clinical predictive validity; dietary supplements; model systems; rigor and replicability; value of information
MeSH headings : Animals; Biological Products / pharmacology; Drug Evaluation, Preclinical; Ethnobotany; Humans; Translational Research, Biomedical / standards
TL;DR: More effective bridging from NP research to CT was the goal of a September, 2018 transdisciplinary workshop, and participants emphasized that replicability and likelihood of successful translation depend on rigor in experimental design, interpretation, and reporting across the continuum of NP research. (via Semantic Scholar)
Source: Web Of Science
Added: February 3, 2020

2020 journal article

In Vitro Bioaccessibility of Carotenoids and Chlorophylls in a Diverse Collection of Spinach Accessions and Commercial Cultivars

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68(11), 3495–3505.

By: M. Hayes n, M. Pottorff n, C. Kay n, A. Van Deynze*, J. Osorio-Marin*, M. Lila n, M. Iorrizo n, M. Ferruzzi n

author keywords: spinach; carotenoids; lutein; beta-carotene; chlorophyll; genotypes; bioaccessibility; in vitro digestion
MeSH headings : Carotenoids; Chlorophyll; Chlorophyll A; Spinacia oleracea / genetics; beta Carotene
TL;DR: The results suggest that carotenoid and chlorophyll bioaccessible contents may vary based on spinach genotypes and may be stable across seasons. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: May 8, 2020

2020 journal article

Increasing Doses of Blueberry Polyphenols Alters Colonic Metabolism and Calcium Absorption in Ovariectomized Rats

MOLECULAR NUTRITION & FOOD RESEARCH, 64(12).

By: D. Cladis*, H. Debelo n, P. Lachcik*, M. Ferruzzi n & C. Weaver*

author keywords: blueberries; calcium absorption; colonic metabolism; pharmacokinetics; polyphenols
MeSH headings : Animals; Blueberry Plants / chemistry; Calcium / pharmacokinetics; Colon / drug effects; Colon / metabolism; Dietary Supplements; Dose-Response Relationship, Drug; Female; Flavonoids / urine; Hippurates / urine; Intestinal Absorption / drug effects; Ovariectomy; Phenols / metabolism; Phenols / urine; Polyphenols / administration & dosage; Polyphenols / analysis; Polyphenols / pharmacology; Rats, Sprague-Dawley
TL;DR: It is indicated that increased doses of blueberry polyphenols induce changes in intestinal phenolic metabolism and increase calcium absorption, and Calcium absorption was significantly increased in the highest dose group. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 8, 2020

2020 review

Insights from in vitro exploration of factors influencing iron, zinc and provitamin A carotenoid bioaccessibility and intestinal absorption from cereals

[Review of ]. JOURNAL OF CEREAL SCIENCE, 96.

author keywords: Cereals; Iron; Zinc; Provitamin A carotenoids; Bioaccessibility; In vitro methods
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: January 19, 2021

2020 journal article

Modulating Phenolic Bioaccessibility and Glycemic Response of Starch-Based Foods in Wistar Rats by Physical Complexation between Starch and Phenolic Acid

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68(46), 13257–13266.

By: M. Li n, L. Griffin n, S. Corbin n, A. Neilson n & M. Ferruzzi n

author keywords: LC-MS; in vitro bioaccessibility; cellular uptake efficiency; postprandial glycemic response; Caco-2 human intestinal cells; starch-phenolic complexes
MeSH headings : Animals; Blood Glucose / metabolism; Caco-2 Cells; Glycemic Index; Humans; Hydroxybenzoates / metabolism; Intestines; Male; Phenols / metabolism; Rats; Rats, Wistar; Solanum tuberosum / metabolism; Starch / analysis; Starch / metabolism; Zea mays / metabolism
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: January 4, 2021

2020 journal article

Phenolic compounds are less degraded in presence of starch than in presence of proteins through processing in model porridges

FOOD CHEMISTRY, 309.

By: M. Ferruzzi n, B. Hamaker* & N. Bordenave

author keywords: Starch; Porridge; Processing; In vitro digestion; Gallic acid; Catechin; Epigallocatechin gallate; V-complex
MeSH headings : Catechin / analogs & derivatives; Catechin / chemistry; Catechin / metabolism; Food Handling / methods; Gallic Acid / chemistry; Gallic Acid / metabolism; Gelatin / chemistry; Gelatin / metabolism; Phenols / chemistry; Phenols / metabolism; Proteins / chemistry; Proteins / metabolism; Starch / chemistry; Starch / metabolism
TL;DR: It was observed that phenolics were less degraded in presence of starch only than in Presence of starch + proteins, and this protection seemed to be linked to the ability of the phenolic compounds to form V-type inclusion complexes with starch, with GA, CAT and EGCG in decreasing order of protection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: December 30, 2019

2020 review

Potential health benefits of (poly)phenols derived from fruit and 100% fruit juice

[Review of ]. NUTRITION REVIEWS, 78(2), 145–174.

By: K. Ho*, M. Ferruzzi n & J. Wightman*

author keywords: cardiovascular; diabetes; exercise; fruit (poly)phenol; 100% juice; neurocognitive; obesity; performance
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Anthocyanins / pharmacology; Biological Availability; Cardiovascular Diseases / diet therapy; Cardiovascular Diseases / prevention & control; Child; Clinical Trials as Topic; Cognition / drug effects; Female; Flavanones / pharmacology; Flavonoids / metabolism; Flavonoids / pharmacokinetics; Flavonoids / pharmacology; Fruit / chemistry; Fruit and Vegetable Juices / analysis; Humans; Male; Middle Aged; Phenols / pharmacology; Polyphenols / metabolism; Polyphenols / pharmacokinetics; Polyphenols / pharmacology; Young Adult
TL;DR: The aim of this narrative review was to provide an overview of fruit (poly)phenols and their potential health benefits and to elucidate protective mechanisms and align with processing and consumer products. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 5, 2020

2020 journal article

Processing influences on food polyphenol profiles and biological activity

CURRENT OPINION IN FOOD SCIENCE, 32, 90–102.

By: H. Debelo n, M. Li n & M. Ferruzzi n

TL;DR: Growing evidence that polyphenol–macronutrient interactions can impactpolyphenol profiles, bioavailability and bioactivities, including interactions with microbiota, suggest that consideration of the broader food matrix is critical in translation of experimental concepts to human foods. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: January 11, 2021

2020 review

Short-Term Tea Consumption Is Not Associated with a Reduction in Blood Lipids or Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

[Review of ]. JOURNAL OF NUTRITION, 150(12), 3269–3279.

By: E. Igho-Osagie*, K. Cara*, D. Wang, Q. Yao*, L. Penkert*, A. Cassidy*, M. Ferruzzi n, P. Jacques* ...

author keywords: Camellia sinensis; tea; blood pressure; lipids; cardiovascular diseases
MeSH headings : Blood Pressure / drug effects; Drug Administration Schedule; Humans; Lipids / blood; Tea
TL;DR: Short-term tea consumption does not appear to significantly affect blood pressure or lipids in healthy or at-risk adults, although the evidence is limited by insufficient power to detect changes in these CVD biomarkers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 4, 2021

2020 journal article

Starch-phenolic complexes are built on physical CH-pi interactions and can persist after hydrothermal treatments altering hydrodynamic radius and digestibility of model starch-based foods

FOOD CHEMISTRY, 308.

By: M. Li n, C. Ndiaye*, S. Corbin n, E. Foegeding n & M. Ferruzzi n

author keywords: Starch; Phenolic acids; Starch digestibility; Hydrodynamic radius; NMR; GC-MS
MeSH headings : Calorimetry, Differential Scanning; Gelatin / chemistry; Hydrodynamics; Phenols / chemistry; Starch / chemistry; Zea mays / chemistry
TL;DR: Starch-phenolic complexes under hydrothermal treatments suggested that phenolics may complex with starch through non-covalent CH-π bonds along α-(1 → 4) glycosidic chains. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: November 25, 2019

2020 article

Tea Flavonoids and Risk of Cardiovascular and All-Cause Mortality: A Systematic Review and Meta-Analysis

PROCEEDINGS OF THE NUTRITION SOCIETY, Vol. 79, pp. E209–E209.

By: D. Wang, A. Cassidy, M. Ferruzzi n, P. Jacques*, E. Johnson*, N. Zhao*, M. Shams-White*, M. Karlsen*, T. Wallace*, M. Chung*

TL;DR: Current evidence indicates that increased tea consumption may reduce cardiovascular and all-cause mortality in a dose-response manner. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 27, 2020

2020 review

Update on the bioavailability and chemopreventative mechanisms of dietary chlorophyll derivatives

[Review of ]. NUTRITION RESEARCH, 81, 19–37.

By: M. Hayes n & M. Ferruzzi n

author keywords: Chlorophyll; Chlorophyllin; Bioavailability; Chemopreventative; Gene expression; Antioxidant
MeSH headings : Animals; Anticarcinogenic Agents / administration & dosage; Anticarcinogenic Agents / metabolism; Anticarcinogenic Agents / pharmacokinetics; Anticarcinogenic Agents / pharmacology; Biological Availability; Carcinogens / metabolism; Carcinogens / pharmacokinetics; Chemoprevention; Chlorophyll / administration & dosage; Chlorophyll / analogs & derivatives; Chlorophyll / metabolism; Chlorophyll / pharmacokinetics; Diet; Digestion; Digestive System / metabolism; Humans; Intestinal Absorption; Mutagens / metabolism; Neoplasms / prevention & control; Oxidative Stress; Signal Transduction; Xenobiotics / metabolism
TL;DR: The goals of this review are to provide an update to the comprehensive review of Ferruzzi and Blakeslee (2007) to include new insights into the behavior of chlorophyll derivatives in the gut as well as evidence of the systemic bioavailability of chloropyll derivatives and their metabolites in support of potential impacts in prevention of cancer throughout the body. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 9, 2020

2020 review

What is food-to-food fortification? A working definition and framework for evaluation of efficiency and implementation of best practices

[Review of ]. COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, 19(6), 3618–3658.

By: J. Kruger*, J. Taylor*, M. Ferruzzi n & H. Debelo n

author keywords: beta-carotene; essential minerals; hidden hunger; iron; micronutrient malnutrition; staple food; vitamin A; zinc
MeSH headings : Biological Availability; Food, Fortified; Iron; Micronutrients / chemistry; Micronutrients / deficiency; Micronutrients / supply & distribution; Provitamins; Starch; Vitamin A; Zinc
TL;DR: Comparing FtFF with other main food-based strategies clearly differentiates FtFF as an emerging strategy with the potential to address multiple micronutrient deficiencies simultaneously, with little dietary change required by consumers. (via Semantic Scholar)
Source: Web Of Science
Added: October 5, 2020

2019 journal article

An Anthocyanin-Rich Mixed-Berry Intervention May Improve Insulin Sensitivity in a Randomized Trial of Overweight and Obese Adults

NUTRIENTS, 11(12).

author keywords: berries; insulin sensitivity; diabetes; T2DM
MeSH headings : Adult; Aged; Anthocyanins / chemistry; Anthocyanins / pharmacology; Cross-Over Studies; Diet; Female; Food Analysis; Fruit / chemistry; Fruit and Vegetable Juices / analysis; Glucose Tolerance Test; Humans; Insulin Resistance; Male; Middle Aged; Overweight; Phenols / chemistry
TL;DR: The potential for mixed berry preparations to improve post-prandial insulin response is suggested, possibly related to flavonoid content, fiber content, or both. (via Semantic Scholar)
Source: Web Of Science
Added: February 3, 2020

2019 journal article

Assessment of oxygen sequestration on effectiveness of Purdue Improved Crop Storage (PICS) bags in reducing carotenoid degradation during post-harvest storage of two biofortified orange maize genotypes

JOURNAL OF CEREAL SCIENCE, 87, 68–77.

By: S. Nkhata*, D. Ortiz*, D. Baributsa*, B. Hamaker*, T. Rocheford* & M. Ferruzzi n

author keywords: Carotenoid; Biofortified orange maize; Provitamin A; Post-harvest storage
TL;DR: This study assessed the utility of the Purdue Improved Crop Storage bags with a specific focus on retention of provitamin A and other carotenoids in two biofortified maize genotypes (OPVI and OPVII). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 1, 2019

2019 journal article

Banana flour phenolics inhibit trans-epithelial glucose transport from wheat cakes in a coupled in vitro digestion/Caco-2 cell intestinal model

FOOD & FUNCTION, 10(10), 6300–6311.

By: J. Pico*, S. Corbin n, M. Ferruzzi n & M. Martinez*

MeSH headings : Caco-2 Cells; Digestion; Flour / analysis; Glucose / metabolism; Humans; Intestinal Mucosa / metabolism; Musa / chemistry; Musa / metabolism; Phenols / metabolism; Triticum / chemistry; Triticum / metabolism
TL;DR: Results suggested that the amounts of quercetin and myricetin, even in traces, were critical determinants of glucose transport inhibition, which may contribute to the ability of flavonoid-rich food to regulate glucose homeostasis of meals rich in available carbohydrates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: November 4, 2019

2019 journal article

Fate of lutein-containing zein nanoparticles following simulated gastric and intestinal digestion

Food Hydrocolloids, 87, 229–236.

By: C. Cheng*, M. Ferruzzi n & O. Jones*

author keywords: Zein; Nanoparticle; Lutein; Encapsulation; Bioaccessibility
TL;DR: The findings indicated that ZNPs provided a degree of physical protection to encapsulated carotenoids in gastric conditions yet might partially interfere with certain pathways forCarotenoid bioaccessibility. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: February 24, 2020

2019 journal article

Improving iron and zinc bioaccessibility through food-to-food fortification of pearl millet with tropical plant foodstuffs (moringa leaf powder, roselle calyces and baobab fruit pulp)

JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, 56(4), 2244–2256.

By: R. Merwe*, J. Kruger*, M. Ferruzzi n, K. Duodu* & J. Taylor*

author keywords: Baobab; Bioaccessibility; Fortification; Iron; Moringa; Roselle; Zinc
TL;DR: Food-to-food fortification of staple cereal foods with moringa leaves, roselle calyces or baobab fruit pulp plus a provitamin A source can potentially sustainably improve iron and zinc bioavailability in the diets of at-risk communities in the Semi-arid Tropics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 15, 2019

2019 journal article

Manufacturing the ultimate green banana flour: Impact of drying and extrusion on phenolic profile and starch bioaccessibility

FOOD CHEMISTRY, 297.

author keywords: Banana starch; Freeze-drying; Oven drying; Extrusion cooking; Resistant starch; Phenolic compounds
MeSH headings : Antioxidants; Chromatography, High Pressure Liquid; Desiccation; Dietary Fiber / analysis; Flavonols / analysis; Flavonols / chemistry; Flour / analysis; Freeze Drying; Hydroxybenzoates / analysis; Hydroxybenzoates / chemistry; Kinetics; Mass Spectrometry; Musa / metabolism; Phenols / analysis; Phenols / chemistry; Starch / metabolism
TL;DR: Banana flours processed by oven-drying and extrusion generally improved the extractability of phenolic acids and flavonols, and Epicatechin, the most abundant phenolic in all flours, was significantly reduced during thermal processing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 22, 2019

2019 journal article

Potato product form impacts in vitro starch digestibility and glucose transport but only modestly impacts 24 h blood glucose response in humans

FOOD & FUNCTION, 10(4), 1846–1855.

MeSH headings : Adult; Biological Transport; Caco-2 Cells; Dietary Carbohydrates / metabolism; Digestion; Fast Foods / analysis; Female; Glucose / metabolism; Glycemic Index; Humans; Intestinal Mucosa / metabolism; Male; Models, Biological; Phenols / metabolism; Solanum tuberosum / chemistry; Solanum tuberosum / metabolism; Starch / chemistry; Starch / metabolism; Young Adult
TL;DR: The results suggest that potato phenolics have only a modest influence on acute glycemic responses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: May 28, 2019

2019 journal article

Starch digested product analysis by HPAEC reveals structural specificity of flavonoids in the inhibition of mammalian alpha-amylase and alpha-glucosidases

FOOD CHEMISTRY, 288, 413–421.

By: J. Lim*, X. Zhang*, M. Ferruzzi n & B. Hamaker*

author keywords: Starch digestive enzymes; Inhibition; Flavonoids; HPAEC; Ring structure
MeSH headings : Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Colorimetry; Enzyme Assays; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / metabolism; Flavonoids / chemistry; Flavonoids / metabolism; Kinetics; Starch / analysis; Starch / metabolism; Substrate Specificity; alpha-Amylases / antagonists & inhibitors; alpha-Amylases / metabolism; alpha-Glucosidases / chemistry; alpha-Glucosidases / metabolism
TL;DR: This study shows that direct measurement of starch digestion products by HPAEC should be used in inhibition studies, and provides insights into structure-function aspects of polyphenols in controlling starch digestion rate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 9, 2019

2019 journal article

Steeping of Biofortified Orange Maize Genotypes for Ogi Production Modifies Pasting Properties and Carotenoid Stability

AGRONOMY-BASEL, 9(11).

By: D. Ortiz*, S. Nkhata*, T. Rocheford* & M. Ferruzzi n

author keywords: biofortified maize; pro-vitamin A; lutein; zeaxanthin; carotenoids; degradation; retention; steeping; fermentation; food processing; nutritional impact
Source: Web Of Science
Added: December 30, 2019

2019 article

The Roles of Food Processing in Translation of Dietary Guidance for Whole Grains, Fruits, and Vegetables

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 10, Vol. 10, pp. 569–596.

By: M. Li n, K. Ho*, M. Hayes n & M. Ferruzzi n

author keywords: food processing; dietary guidance; whole grain; fruit; vegetable
MeSH headings : Food Handling; Fruit; Humans; Nutrition Policy; Vegetables; Whole Grains
TL;DR: In this review, select processing strategies for whole grains, fruits, and vegetables are described to show how DGA principles can guide processing efforts to create healthier products. (via Semantic Scholar)
Source: Web Of Science
Added: April 22, 2019

2018 journal article

A Comprehensive Database and Analysis Framework To Incorporate Multiscale Data Types and Enable Integrated Analysis of Bioactive Polyphenols

MOLECULAR PHARMACEUTICS, 15(3), 840–850.

By: L. Ho*, H. Cheng*, J. Wang*, J. Simon*, Q. Wu*, D. Zhao*, E. Carry, M. Ferruzzi n ...

author keywords: multiple scale data set; integrated analysis; directional networks; dietary botanicals and polyphenol metabolites
MeSH headings : Data Analysis; Databases, Factual; Datasets as Topic; Drug Development / methods; Phytochemicals / pharmacology; Polyphenols / chemistry; Polyphenols / pharmacology
TL;DR: An integrative analysis framework is presented that is based on data-driven characterizations of interactions between BDPP-derived phenolic metabolites and their mechanisms of action, as well as synergism and/or potential cancellation of biological functions. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Carotenoid Stability during Dry Milling, Storage, and Extrusion Processing of Biofortified Maize Genotypes

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66(18), 4683–4691.

By: D. Ortiz*, A. Ponrajan*, J. Pablo Bonnet*, T. Rocheford* & M. Ferruzzi n

author keywords: carotenoids; biofortified maize; provitamin A; extrusion; dry milling; processing
MeSH headings : Breeding; Carotenoids / chemistry; Food Handling / methods; Food Storage; Genotype; Seeds / chemistry; Zea mays / chemistry; Zea mays / genetics
TL;DR: The notion that postharvest losses in maize milled fractions may be dependent, in part, on genotype and that extrusion processing may provide an option for preserving biofortified maize products is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Complexation with phenolic acids affect rheological properties and digestibility of potato starch and maize amylopectin

FOOD HYDROCOLLOIDS, 77, 843–852.

By: M. Li n, C. Pernell n & M. Ferruzzi n

author keywords: Starch-phenolics interactions; Rapid visco analyser; LC-MS/MS; FTIR; Starch hydrolysis; Iodine binding technique
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Effect of adding milk to black tea on vascular function in healthy men and women: a randomised controlled crossover trial

Food & Function, 9(12), 6307–6314.

By: A. Ahmad*, L. Rich*, H. Koch*, K. Croft*, M. Ferruzzi n, C. Kay n, J. Hodgson*, N. Ward*

MeSH headings : Adult; Animals; Blood Pressure; Brachial Artery / physiology; Camellia sinensis / chemistry; Camellia sinensis / metabolism; Cross-Over Studies; Female; Heart Rate; Humans; Male; Milk / metabolism; Tea / metabolism; Vasodilation; Young Adult
TL;DR: The addition of milk to black tea alters the acute/short-term impact of regular tea consumption on vascular function and blood pressure in young healthy men and women. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: December 8, 2019

2018 journal article

High-density linkage mapping of vitamin E content in maize grain

Molecular Breeding, 38(3).

By: M. Fenton*, B. Owens*, A. Lipka*, D. Ortiz*, T. Tiede*, M. Mateos-Hernandez*, M. Ferruzzi*, T. Rocheford*

author keywords: High-density linkage mapping; Vitamin E; Tocochromanol; Homogentisate phytyltransferase
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: February 24, 2020

2018 journal article

Impact of potato processing on nutrients, phytochemicals, and human health

Critical Reviews in Food Science and Nutrition, 58(1), 146–168.

By: A. Furrer*, M. Chegeni* & M. Ferruzzi n

author keywords: Potatoes; nutritional quality; processing; phytochemicals
MeSH headings : Biological Availability; Carotenoids / analysis; Dietary Carbohydrates / analysis; Dietary Carbohydrates / metabolism; Dietary Fiber / administration & dosage; Dietary Proteins / analysis; Dietary Proteins / chemistry; Dietary Proteins / metabolism; Digestion; Food Handling / methods; Health Status; Humans; Micronutrients / administration & dosage; Minerals / pharmacokinetics; Nutritive Value; Phenols / analysis; Phytochemicals / analysis; Phytochemicals / pharmacokinetics; Plant Tubers / chemistry; Solanum tuberosum / growth & development; Starch / analysis; Vitamins / pharmacokinetics
TL;DR: This review summarizes critical information on nutritional profiles of potatoes and their processed products and describes the state of the science relative to the influence of in-home and common commercial processing on nutritional quality and potential impacts on human health. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: December 21, 2020

2018 journal article

Interactions Between Flavonoid-Rich Extracts and Sodium Caseinate Modulate Protein Functionality and Flavonoid Bioaccessibility in Model Food Systems

JOURNAL OF FOOD SCIENCE, 83(5), 1229–1236.

By: J. Elegbede*, M. Li n, O. Jones*, O. Campanella* & M. Ferruzzi n

author keywords: flavonoids; grape seed extract; green tea extract; sodium caseinate
MeSH headings : Biological Availability; Caseins / chemistry; Caseins / pharmacokinetics; Flavonoids / chemistry; Flavonoids / pharmacokinetics; Models, Biological; Plant Extracts / chemistry; Plant Extracts / pharmacokinetics; Tea / chemistry
TL;DR: It is suggested that SCN-flavonoid binding interactions can modulate protein functionality leading to difference in performance and flavonoid bioaccessibility of protein-based products. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Measuring consumers' interest in instant fortified pearl millet products: a field experiment in Touba, Senegal

Journal of the Science of Food and Agriculture, 98(6), 2320–2331.

By: H. De Groote*, S. Kariuki*, D. Traore*, J. Taylor*, M. Ferruzzi* & B. Hamaker*

author keywords: consumers; millet; instant; Africa
MeSH headings : Adult; Consumer Behavior; Female; Flour / analysis; Food, Fortified / analysis; Humans; Male; Middle Aged; Pennisetum / chemistry; Random Allocation; Senegal; Taste; Young Adult
TL;DR: There is a potential market in low-income African countries for instant and fortified cereal food products, but likely in the higher income and education groups, but the increased cost needs to be compared to the premiums consumers are willing to pay. (via Semantic Scholar)
Source: Crossref
Added: December 21, 2020

2018 journal article

Potato phenolics impact starch digestion and glucose transport in model systems but translation to phenolic rich potato chips results in only modest modification of glycemic response in humans

NUTRITION RESEARCH, 52, 57–70.

By: S. Moser*, I. Aragon*, A. Furrer*, J. Van Klinken*, M. Kaczmarczyk*, B. Lee*, J. George*, B. Hamaker*, R. Mattes*, M. Ferruzzi*

author keywords: Potatoes; Chloro genic acid; Anthocyanins; Starch Digestion; Glucose transport; Glycemic; Response
MeSH headings : Adolescent; Adult; Anthocyanins / analysis; Anthocyanins / pharmacology; Biological Transport; Blood Glucose / metabolism; Caco-2 Cells; Chlorogenic Acid / analysis; Chlorogenic Acid / pharmacology; Digestion; Food Handling; Humans; Intestinal Absorption / drug effects; Intestines; Middle Aged; Phenols / analysis; Phenols / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology; Polyphenols / analysis; Polyphenols / pharmacology; Solanum tuberosum / chemistry; Starch / metabolism; Young Adult
TL;DR: The results suggest that potato phenolics may play a modest role in modulation of glycemic response and these effects may result in subtle differences between consumer products. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Pro-vitamin A carotenoids stability and bioaccessibility from elite selection of biofortified cassava roots (Manihot esculenta, Crantz) processed to traditional flours and porridges

Food & Function, 9(9), 4822–4835.

By: I. Aragón*, H. Ceballos*, D. Dufour* & M. Ferruzzi n

MeSH headings : Biofortification; Carotenoids / analysis; Carotenoids / biosynthesis; Carotenoids / metabolism; Child; Child, Preschool; Colombia; Cooking; Crops, Agricultural / chemistry; Crops, Agricultural / growth & development; Crops, Agricultural / metabolism; Crops, Agricultural / microbiology; Crosses, Genetic; Developing Countries; Digestion; Fermented Foods / analysis; Fermented Foods / microbiology; Food Handling; Hot Temperature / adverse effects; Humans; Manihot / chemistry; Manihot / growth & development; Manihot / metabolism; Manihot / microbiology; Nutritive Value; Plant Breeding; Plant Roots / chemistry; Plant Roots / growth & development; Plant Roots / metabolism; Plant Roots / microbiology; Recommended Dietary Allowances; Selection, Genetic; Species Specificity
TL;DR: The results suggest that genotypic and other factors may impact release and availability of carotenoids and that consideration of both genetics and processing may be warranted in the selection of biofortified cassava cultivars to advance into the application. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: December 21, 2020

2017 journal article

Adaptation in Caco-2 Human Intestinal Cell Differentiation and Phenolic Transport with Chronic Exposure to Blackberry (Rubus sp.) Extract

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 65(13), 2694–2701.

By: B. Redan*, G. Albaugh*, C. Charron*, J. Novotny* & M. Ferruzzi*

author keywords: anthocyanins; bioavailability; blackberry; Caco-2; phenolics
MeSH headings : ATP-Binding Cassette Transporters / metabolism; Biological Transport; Caco-2 Cells; Cell Differentiation; Fruit / metabolism; Glucuronosyltransferase / metabolism; Humans; Intestinal Mucosa / metabolism; Intestines / cytology; Intestines / enzymology; Phenols / metabolism; Plant Extracts / metabolism; Rubus / metabolism
TL;DR: Adaptation to blackberry extract exposure may impact intestinal transport and metabolism of phenolics, and alterations in mRNA expression of key phase II metabolizing enzymes and transport proteins were observed with treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Changes in phenolic content of commercial potato varieties through industrial processing and fresh preparation

FOOD CHEMISTRY, 218, 47–55.

By: A. Furrer*, D. Cladis*, A. Kurilich*, R. Manoharan* & M. Ferruzzi*

author keywords: Potato; Potato products; Phenolics; Chlorogenic acid; Anthocyanin; Processing stability
MeSH headings : Anthocyanins / analysis; Chlorogenic Acid / analysis; Food Analysis; Food Handling; Phenols / analysis; Phytochemicals / analysis; Solanum tuberosum / chemistry; Solanum tuberosum / classification
TL;DR: Overall, industrially processed potato products compare favorably to fresh preparation in levels and recovery of phenolics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Differentiated Caco-2 cell monolayers exhibit adaptation in the transport and metabolism of flavan-3-ols with chronic exposure to both isolated flavan-3-ols and enriched extracts

FOOD & FUNCTION, 8(1), 111–121.

By: B. Redan*, M. Chegeni & M. Ferruzzi*

MeSH headings : Biological Transport; Caco-2 Cells; Catechin / analogs & derivatives; Catechin / metabolism; Catechol O-Methyltransferase / genetics; Catechol O-Methyltransferase / metabolism; Cell Differentiation; Flavonoids / metabolism; Humans; Intestinal Mucosa / metabolism; Intestines / cytology; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins / genetics; Multidrug Resistance-Associated Proteins / metabolism
TL;DR: The results suggest that intestinal adaptation to both isolated flavan-3-ols and extracts rich in these compounds alters their intestinal transport and metabolism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 review

Establishing Standards on Colors from Natural Sources

[Review of ]. JOURNAL OF FOOD SCIENCE, 82(11), 2539–2553.

By: J. Simon*, E. Decker*, M. Ferruzzi n, M. Giusti*, C. Mejia*, M. Goldschmidt*, S. Talcott*

author keywords: adulteration; food additives; food safety; natural colors; synthetic colors
MeSH headings : Animals; Coloring Agents / standards; Commerce; Food Additives / standards; Food Coloring Agents / standards; Food Contamination; Humans; Legislation, Drug; Legislation, Food; Pigments, Biological / standards; Quality Control; United States; United States Food and Drug Administration
TL;DR: A significant risk of adulteration of natural colors exists, ranging from simple misbranding or misuse of the term "natural" on a product label to potentially serious cases of physical, chemical, and/or microbial contamination from raw material sources, improper processing methods, or intentional postproduction adulterations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Genetic analysis of provitamin A carotenoid β-cryptoxanthin concentration and relationship with other carotenoids in maize grain (Zea mays L.)

Molecular Breeding, 37(10).

By: R. Venado*, B. Owens*, D. Ortiz*, T. Lawson*, M. Mateos-Hernandez*, M. Ferruzzi*, T. Rocheford*

author keywords: Carotenoids; beta-Cryptoxanthin; Quantitative trait loci (QTL); Provitamin A; Colorimeter; Visual score; Ratios
TL;DR: This study was designed to enhance the understanding of the genetic control of: levels of β-cryptoxanthin, conversion ofβ-carotene into β- cryptoxanth in and zeaxanth in, conversion and flux into and within the β-branch of carotenoid pathway. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: August 28, 2020

2017 journal article

Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat

Molecular Nutrition & Food Research, 61(10), 1700111.

By: T. Chen*, M. Ferruzzi*, Q. Wu*, J. Simon*, S. Talcott*, J. Wang*, L. Ho*, G. Todd* ...

author keywords: Bioavailability; Brain; Diabetes; Grape polyphenols; Pharmacokinetics
MeSH headings : Animals; Anthocyanins / blood; Anthocyanins / pharmacokinetics; Anthocyanins / urine; Biological Availability; Blood Glucose / metabolism; Brain / drug effects; Brain / metabolism; Catechin / blood; Catechin / pharmacokinetics; Catechin / urine; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Type 2 / blood; Flavonoids / blood; Flavonoids / pharmacokinetics; Flavonoids / urine; Grape Seed Extract / blood; Grape Seed Extract / pharmacokinetics; Grape Seed Extract / urine; Male; Polyphenols / blood; Polyphenols / pharmacokinetics; Polyphenols / urine; Quercetin / blood; Quercetin / pharmacokinetics; Quercetin / urine; Rats; Rats, Zucker; Resveratrol; Stilbenes / blood; Stilbenes / pharmacokinetics; Stilbenes / urine; Tandem Mass Spectrometry; Vitis / chemistry
TL;DR: Diabetes may alter the overall bioavailability of some polyphenols in plasma and brain in part due to higher urinary clearance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2017 review

On the demand for agritourism: a cursory review of methodologies and practice

[Review of ]. TOURISM PLANNING & DEVELOPMENT, 14(1), 139–148.

author keywords: Agritourism; demand; stated preference; revealed preference; tourism flow
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Phenolics from Whole Grain Oat Products as Modifiers of Starch Digestion and Intestinal Glucose Transport

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 65(32), 6831–6839.

By: M. Li n, K. Koecher*, L. Hansen* & M. Ferruzzi n

author keywords: oat phenolics; avenanthramides; LC-MS; Caco-2; alpha-amylase
MeSH headings : Avena / metabolism; Biological Transport; Caco-2 Cells; Digestion; Glucose / metabolism; Humans; Intestinal Mucosa / metabolism; Phenols / metabolism; Starch / metabolism; Whole Grains / metabolism
TL;DR: Results suggest phenolics might be a factor modulating glycemic response of oat products and relevance to whole food systems is suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 review

Satisfying America's Fruit Gap: Summary of an Expert Roundtable on the Role of 100% Fruit Juice

[Review of ]. JOURNAL OF FOOD SCIENCE, 82(7), 1523–1534.

By: C. Byrd-Bredbenner*, M. Ferruzzi n, V. Fulgoni, R. Murray*, E. Pivonka & T. Wallace*

author keywords: dietary guidelines; diet quality; 100% fruit juice; nutrient intake; nutrition policy
MeSH headings : Adolescent; Animals; Beverages; Child; Child, Preschool; Dental Caries; Diet; Energy Intake; Feeding Behavior; Female; Fruit; Fruit and Vegetable Juices; Health Promotion; Humans; Infant; Milk; Nutrition Policy; Nutritional Status; Obesity; Sweetening Agents; United States
TL;DR: There is no science-based reason to restrict access to 100% fruit juice in public health nutrition policy and programs such as the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

The effect of obesity and repeated exposure on pharmacokinetic response to grape polyphenols in humans

MOLECULAR NUTRITION & FOOD RESEARCH, 61(11).

By: J. Novotny*, T. Chen*, A. Terekhov*, S. Gebauer*, D. Baer*, L. Ho*, G. Pasinetti*, M. Ferruzzi n

author keywords: Bioavailability; BMI; Catechin; Epicatechin; Polyphenol; Quercetin; Resveratrol
MeSH headings : Aged; Anti-Obesity Agents / administration & dosage; Anti-Obesity Agents / blood; Anti-Obesity Agents / metabolism; Anti-Obesity Agents / therapeutic use; Area Under Curve; Body Mass Index; Dietary Supplements; Female; Fruit / chemistry; Fruit and Vegetable Juices; Humans; Kinetics; Male; Middle Aged; Obesity / blood; Obesity / diet therapy; Obesity / metabolism; Overweight / blood; Overweight / diet therapy; Overweight / metabolism; Pilot Projects; Plant Extracts / administration & dosage; Plant Extracts / metabolism; Plant Extracts / therapeutic use; Polyphenols / administration & dosage; Polyphenols / blood; Polyphenols / metabolism; Polyphenols / therapeutic use; Resveratrol; Seeds / chemistry; Stilbenes / administration & dosage; Stilbenes / blood; Stilbenes / metabolism; Stilbenes / therapeutic use; Vitis / chemistry
TL;DR: Results suggest that that obesity and repeated exposure may modify polyphenol absorption and/or metabolism in humans. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 article

Vitamin A

Debelo, H., Novotny, J. A., & Ferruzzi, M. G. (2017, November). ADVANCES IN NUTRITION, Vol. 8, pp. 992–994.

By: H. Debelo*, J. Novotny* & M. Ferruzzi n

MeSH headings : Humans; Nutritional Requirements; Nutritional Status; Vitamin A / blood; Vitamin A / therapeutic use; Vitamin A Deficiency / blood; Vitamin A Deficiency / complications; Vitamins / blood; Vitamins / therapeutic use
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice

The Journal of Nutritional Biochemistry, 34, 73–82.

By: M. Shahnazari*, R. Turner*, U. Iwaniec*, T. Wronski*, M. Li*, M. Ferruzzi*, R. Nissenson*, B. Halloran*

author keywords: Plum; Bone; Osteoclast; Osteoblast; Nutrition; Peak bone mass
MeSH headings : Animals; Biomarkers / blood; Bone Development; Bone Marrow Cells / cytology; Bone Marrow Cells / immunology; Bone Marrow Cells / metabolism; Bone Marrow Cells / pathology; Bone Remodeling; Bone Resorption / immunology; Bone Resorption / metabolism; Bone Resorption / pathology; Bone Resorption / prevention & control; Bone and Bones / cytology; Bone and Bones / immunology; Bone and Bones / metabolism; Bone and Bones / pathology; Cells, Cultured; Collagen Type I / blood; Cytokines / antagonists & inhibitors; Cytokines / blood; Food, Preserved; Fruit; Functional Food; Gene Expression Regulation, Developmental; Male; Mice, Inbred C57BL; Osteoblasts / cytology; Osteoblasts / immunology; Osteoblasts / metabolism; Osteoblasts / pathology; Osteoclasts / cytology; Osteoclasts / immunology; Osteoclasts / metabolism; Osteoclasts / pathology; Peptide Fragments / blood; Peptides / blood; Prunus domestica
TL;DR: The effects of DP on bone were accompanied by a decline in interleukins, TNF and MCP-1, suggesting that DP is acting in part through the immune system to suppress inflammatory activity and reduce the size of the osteoclast precursor pool. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: February 24, 2020

2016 journal article

Influence of Temperature and Humidity on the Stability of Carotenoids in Biofortified Maize (Zea maysL.) Genotypes during Controlled Postharvest Storage

Journal of Agricultural and Food Chemistry, 64(13), 2727–2736.

By: D. Ortiz*, T. Rocheford* & M. Ferruzzi*

author keywords: biofortified corn; carotenoid degradation; retention; nutritional impact; postharvest storage
MeSH headings : Algorithms; Carotenoids / analysis; Carotenoids / chemistry; Edible Grain / chemistry; Genotype; Humidity; Models, Chemical; Temperature; Zea mays / chemistry; Zea mays / genetics
TL;DR: The results of this study support the notion that effective control of moisture content and temperature of the kernels during storage conditions is essential to reduce the speed of degradative reactions. (via Semantic Scholar)
Source: Crossref
Added: January 24, 2021

2016 journal article

Low bioaccessibility of vitamin D2from yeast-fortified bread compared to crystalline D2bread and D3from fluid milks

Food & Function, 7(11), 4589–4596.

By: T. Lipkie*, M. Ferruzzi* & C. Weaver*

MeSH headings : Animals; Biological Availability; Bread / analysis; Chromatography, High Pressure Liquid; Ergocalciferols / chemistry; Ergocalciferols / pharmacokinetics; Food Analysis; Food, Fortified; Mass Spectrometry; Milk / chemistry; Yeasts
TL;DR: The results indicate that the low bioavailability of yeast D2 in comparison to other vitamin D2 sources is likely due to entrapment within a less digestible yeast matrix and not only to metabolic differences between vitamins D2 and D3. (via Semantic Scholar)
Source: Crossref
Added: January 24, 2021

2016 journal article

Manipulating Sensory and Phytochemical Profiles of Greenhouse Tomatoes Using Environmentally Relevant Doses of Ultraviolet Radiation

Journal of Agricultural and Food Chemistry, 64(36), 6801–6808.

By: M. Dzakovich*, M. Ferruzzi* & C. Mitchell*

MeSH headings : Antioxidants / metabolism; Carotenoids / analysis; Chromatography, High Pressure Liquid; Food Irradiation; Fruit / chemistry; Fruit / radiation effects; Gene Expression; Genes, Plant; Humans; Solanum lycopersicum / chemistry; Solanum lycopersicum / radiation effects; Phytochemicals / analysis; Polyphenols / analysis; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry; Taste; Ultraviolet Rays
TL;DR: These studies represent the first reported use of environmentally relevant doses of UV radiation throughout the reproductive portion of the tomato plant life cycle to positively enhance the sensory and chemical properties of fruits. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2016 journal article

Phenolic recovery and bioaccessibility from milled and finished whole grain oat products

Food & Function, 7(8), 3370–3381.

By: M. Li*, K. Koecher*, L. Hansen* & M. Ferruzzi*

MeSH headings : Avena / chemistry; Biological Availability; Caco-2 Cells; Caffeic Acids / analysis; Coumaric Acids / analysis; Flour / analysis; Food Handling; Gallic Acid / analysis; Humans; Phenols / analysis; Whole Grains / chemistry; ortho-Aminobenzoates / analysis
TL;DR: It is demonstrated that phenolics naturally present in whole grain oats are recovered well through traditional grain processing, milling and food processing and processing of oat cultivars into a RTE cereal may have a positive impact on the digestive release and bioaccessibility of Oat phenolics in the upper GI tract. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: February 24, 2020

2015 journal article

Carbohydrate and Phytochemical Digestibility in Pasta

Food Engineering Reviews, 8(1), 76–89.

By: G. Camelo-Méndez*, M. Ferruzzi*, G. González-Aguilar* & L. Bello-Pérez*

author keywords: Pasta products; Raw materials; Processing technologies; Carbohydrates digestibility; Phytochemicals; Glycemic index
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: January 21, 2021

2015 journal article

Chemical investigation of commercial grape seed derived products to assess quality and detect adulteration

Food Chemistry, 170, 271–280.

By: T. Villani*, W. Reichert*, M. Ferruzzi*, G. Pasinetti*, J. Simon* & Q. Wu*

author keywords: Grape seed extract; LC-MS; Polyphenol; Proanthocyanidins; Adulteration; Quality control
MeSH headings : Antioxidants / analysis; Chromatography, Liquid / methods; Food Contamination; Grape Seed Extract / chemistry; Mass Spectrometry / methods; Plant Extracts / chemistry; Polyphenols / analysis; Quality Control; Seeds / chemistry; Vitis / chemistry
TL;DR: A TLC method was developed to allow for rapid and inexpensive detection of adulteration in GSE by peanut skin, demonstrating the need for development of quality control standards for GSE. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Correction to Survey of Polyphenol Constituents in Grapes and Grape-Derived Products

Journal of Agricultural and Food Chemistry, 63(14), 3804–3804.

By: Y. Xu, J. Simon, C. Welch, J. Wightman, M. Ferruzzi*, L. Ho, G. Pasinetti, Q. Wu

TL;DR: The author states that Giulio M. Pasinetti holds a Career Scientist Award in the Research and Development unit and is the Director of the Basic and Biomedical Research and Training Program, GRECC, James J. Peters Veterans Affairs Medical Center. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Corrigendum to “Enzymatic synthesis of substituted epicatechins for bioactivity studies in neurological disorders” [Biochem. Biophys. Res. Commun. 417 (1) (6 January 2012) 457–461]

Biochemical and Biophysical Research Communications, 460(2), 489.

By: J. Blount*, M. Ferruzzi*, D. Raftery*, G. Pasinetti* & R. Dixon*

Source: Crossref
Added: August 16, 2021

2015 journal article

Dietary Phenolic Compounds Selectively Inhibit the Individual Subunits of Maltase-Glucoamylase and Sucrase-Isomaltase with the Potential of Modulating Glucose Release

Journal of Agricultural and Food Chemistry, 63(15), 3873–3879.

By: M. Simsek*, R. Quezada-Calvillo*, M. Ferruzzi*, B. Nichols* & B. Hamaker*

author keywords: alpha-glucosidases; inhibition; maltase-glucoamylase; phenolics; sucrase-isomaltase
MeSH headings : Animals; Digestion; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / metabolism; Glucan 1,4-alpha-Glucosidase / chemistry; Glucan 1,4-alpha-Glucosidase / metabolism; Glucose / chemistry; Humans; Kinetics; Mice; Oligo-1,6-Glucosidase / chemistry; Oligo-1,6-Glucosidase / metabolism; Phenol / chemistry; Phenol / metabolism; Sucrase / chemistry; Sucrase / metabolism; alpha-Glucosidases / chemistry; alpha-Glucosidases / metabolism
TL;DR: Inhibition of fast-digesting Ct-MGAM and Ct-SI by EGCG and chlorogenic acid could lead to a slow, but complete, digestion of starch for improved glycemic response of starchy foods with potential health benefit. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Influence of molecular weight on intracellular antioxidant activity of invasive silver carp ( Hypophthalmichthys molitrix ) protein hydrolysates

Journal of Functional Foods, 18, 1158–1166.

By: S. Malaypally*, A. Liceaga*, K. Kim*, M. Ferruzzi*, F. Martin* & R. Goforth*

author keywords: Protein hydrolysates; Intracellular antioxidant activity; Molecular weight; Peptide sequence
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Crossref
Added: February 24, 2020

2015 journal article

Microwave-assisted extraction of lycopene in tomato peels: Effect of extraction conditions on all-trans and cis-isomer yields

LWT - Food Science and Technology, 62(1), 160–168.

By: K. Ho*, M. Ferruzzi*, A. Liceaga* & M. San Martín-González*

author keywords: All-trans-lycopene; Cis-isomers; Microwave-assisted extraction; Response surface methodology
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Crossref
Added: February 24, 2020

2015 journal article

Novel application of brain-targeting polyphenol compounds in sleep deprivation-induced cognitive dysfunction

Neurochemistry International, 89, 191–197.

By: W. Zhao*, J. Wang*, W. Bi*, M. Ferruzzi*, S. Yemul*, D. Freire*, P. Mazzola*, L. Ho*, L. Dubner*, G. Pasinetti*

author keywords: Sleep deprivation; Polyphenols; Cognitive dysfunction; Resilience; Memory consolidation
TL;DR: It is found that BDPP significantly improves sleep deprivation-induced contextual memory deficits, possibly through the activation of CREB and mTOR signaling pathways, and the feasibility of using select brain-targeting polyphenol compounds derived from BDPp as potential therapeutic agents in promoting resilience against sleep deprivation -induced cognitive dysfunction is suggested. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2015 journal article

Plasma bioavailability and regional brain distribution of polyphenols from apple/grape seed and bilberry extracts in a young swine model

Molecular Nutrition & Food Research, 59(12), 2432–2447.

By: T. Chen*, J. Kritchevsky*, K. Hargett*, K. Feller*, R. Klobusnik*, B. Song*, B. Cooper*, Z. Jouni*, M. Ferruzzi*, E. Janle*

author keywords: Anthocyanins; Brain distribution; Catechins; Pharmacokinetics; Polyphenols
MeSH headings : Animals; Anthocyanins / metabolism; Anthocyanins / pharmacokinetics; Biological Availability; Body Weight / drug effects; Brain / drug effects; Brain / metabolism; Dose-Response Relationship, Drug; Eating / drug effects; Grape Seed Extract / chemistry; Liver / drug effects; Liver / enzymology; Malus / chemistry; Plant Extracts / chemistry; Polyphenols / blood; Polyphenols / pharmacokinetics; Polyphenols / urine; Sus scrofa; Tissue Distribution; Vaccinium myrtillus / chemistry; Vitis / chemistry; Weaning
TL;DR: Significant plasma dose-dependence was observed in flavan-3-ol metabolites of the AGSE group and in Mal, Del and Cyn galactosides and Pet, Peo, and Cyn glucosides of the bilberry groups. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization

Molecular Nutrition & Food Research, 59(6), 1025–1040.

By: D. Wang*, L. Ho*, J. Faith*, K. Ono*, E. Janle*, P. Lachcik*, B. Cooper*, A. Jannasch* ...

author keywords: -Amyloid; Bioavailability; Grape seed polyphenol extract; Phenolic metabolites; Proanthocyanidins
MeSH headings : Alzheimer Disease / drug therapy; Amyloid beta-Peptides / antagonists & inhibitors; Amyloid beta-Peptides / metabolism; Animals; Anthocyanins / administration & dosage; Anthocyanins / blood; Anthocyanins / pharmacokinetics; Biological Availability; Brain / metabolism; Fermentation; Gastrointestinal Microbiome; Grape Seed Extract / administration & dosage; Grape Seed Extract / blood; Grape Seed Extract / pharmacokinetics; Hydroxybenzoates / blood; Hydroxybenzoates / metabolism; Intestines / drug effects; Intestines / microbiology; Male; Peptide Fragments / antagonists & inhibitors; Peptide Fragments / metabolism; Phenols / metabolism; Polyphenols / administration & dosage; Polyphenols / blood; Polyphenols / pharmacokinetics; Propionates / metabolism; Rats; Rats, Sprague-Dawley
TL;DR: Important contribution of the intestinal microbiota to the protective activities of GSPE (as well as other polyphenol preparations) in AD is suggested. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2015 journal article

Synthesis and Quantitative Analysis of Plasma-Targeted Metabolites of Catechin and Epicatechin

Journal of Agricultural and Food Chemistry, 63(8), 2233–2240.

By: J. Blount*, B. Redan*, M. Ferruzzi*, B. Reuhs*, B. Cooper*, J. Harwood*, V. Shulaev*, G. Pasinetti*, R. Dixon*

author keywords: catechin; glucuronosylation; O-methylation; phase II metabolites; semisynthesis; structure determination; two-site validation
MeSH headings : Animals; Catechin / blood; Catechin / chemical synthesis; Catechin / metabolism; Grape Seed Extract / blood; Grape Seed Extract / chemical synthesis; Grape Seed Extract / metabolism; Rats
TL;DR: These studies provide a basis for improvements in future work on the bioavailability, metabolism, and mechanism of action of metabolites derived from dietary flavan-3-ols in a range of interventions. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Thermal degradation of green tea flavan-3-ols and formation of hetero- and homocatechin dimers in model dairy beverages

Food Chemistry, 173, 305–312.

By: B. Song*, C. Manganais* & M. Ferruzzi*

author keywords: Flavan-3-ols; Thermal stability; Oxidation; Theasinesin; P-2 dimer; Protein-polyphenol interaction
MeSH headings : Animals; Beverages / analysis; Catechin / analogs & derivatives; Catechin / analysis; Dietary Proteins / analysis; Flavonoids / chemistry; Food Handling / methods; Milk / chemistry; Polyphenols / analysis; Tea / chemistry
TL;DR: The results suggest that protein interactions may be useful in stabilising flavan-3-ols through thermal processing, and the presence of galloyl and hydroxy moieties was associated with higher stability of monomeric flavan 3-ols with increasing protein concentrations, suggesting potential for protein affinity to stabilise flavan -3-ol to thermal treatment. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2014 journal article

Caco-2 accumulation of lutein is greater from human milk than from infant formula despite similar bioaccessibility

Molecular Nutrition & Food Research, 58(10), 2014–2022.

By: T. Lipkie*, D. Banavara*, B. Shah*, A. Morrow*, R. McMahon*, Z. Jouni*, M. Ferruzzi*

author keywords: Breast milk; Carotenoids; Infant formula; Lutein; Pediatric nutrition
MeSH headings : Adult; Biological Transport; Caco-2 Cells; Cohort Studies; Digestion; Enterocytes / metabolism; Fast Foods; Female; Food, Preserved; Humans; Hydrophobic and Hydrophilic Interactions; Infant Formula; Infant, Newborn; Intestinal Absorption; Lactation; Longitudinal Studies; Lutein / chemistry; Lutein / metabolism; Milk, Human; Nutritive Value; Ohio
TL;DR: Assessment of characteristics of human milk and lutein-fortified infant formula and in vitro digestion coupled with Caco-2 human intestinal cell culture suggest that the bioavailability of carotenoids is greater from human milk than infant formula primarily due to intestinal absorptive processes. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2014 journal article

Correction to Survey of Polyphenol Constituents in Grapes and Grape-Derived Products

Journal of Agricultural and Food Chemistry, 62(13), 3010–3010.

By: Y. Xu, J. Simon, C. Welch, J. Wightman, M. Ferruzzi*, L. Ho, G. Pasinetti, Q. Wu

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: August 28, 2020

2014 journal article

Effects of Para-Aminobenzoic Acid (PABA) Form and Administration Mode on PABA Recovery in 24-Hour Urine Collections

Journal of the Academy of Nutrition and Dietetics, 114(3), 457–463.

By: R. Sharma, R. Joy, C. Boushey, M. Ferruzzi*, A. Leonov & M. McCrory

author keywords: Biomarker; Para-aminobenzoic acid; Potassium salt p-aminobenzoate; 24-hour urine collections
MeSH headings : 4-Aminobenzoic Acid / administration & dosage; 4-Aminobenzoic Acid / urine; Adult; Biomarkers / urine; Capsules; Female; Food; Humans; Male; Middle Aged; Patient Compliance; Time Factors; Urine Specimen Collection / methods
TL;DR: It is suggested that aminobenzoate potassium may be used as an alternative to PABA for assessing the completeness of 24-hour urine collections and to track compliance with consuming provided diets in community-dwelling studies. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2014 journal article

Nature and consequences of non-covalent interactions between flavonoids and macronutrients in foods

Food Funct., 5(1), 18–34.

By: N. Bordenave*, B. Hamaker* & M. Ferruzzi*

MeSH headings : Carbohydrates / chemistry; Flavonoids / chemistry; Food; Food Analysis; Lipids / chemistry; Plant Extracts / chemistry
TL;DR: The fundamental bases for non-covalent interactions, their occurrence in food and beverage systems and their impact on the physico-chemical, organoleptic and some nutritional properties of food are reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: August 28, 2020

2014 journal article

Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease

Brain Research, 1555, 60–77.

By: K. Strathearn*, G. Yousef n, M. Grace n, S. Roy*, M. Tambe*, M. Ferruzzi*, Q. Wu*, J. Simon* ...

Contributors: K. Strathearn*, G. Yousef n, M. Grace n, S. Roy*, M. Tambe*, M. Ferruzzi*, Q. Wu*, J. Simon*, M. Lila n, J. Rochet*

author keywords: Anthocyanin; Microglial activation; Mitochondria; Parkinson's disease; Proanthocyanidin; Rotenone
MeSH headings : Animals; Anthocyanins / therapeutic use; Cells, Cultured; Dopaminergic Neurons / drug effects; Dopaminergic Neurons / metabolism; Mice; Microglia / drug effects; Mitochondria / drug effects; Mitochondria / metabolism; Neuroprotective Agents / therapeutic use; Parkinson Disease / drug therapy; Parkinson Disease / metabolism; Phytotherapy; Plant Extracts / therapeutic use; Proanthocyanidins / therapeutic use; Rotenone / toxicity; Tyrosine 3-Monooxygenase / metabolism
TL;DR: It is suggested that anthocyanin- and proanthocyanidin-rich botanical extracts may alleviate neurodegeneration in PD via enhancement of mitochondrial function. (via Semantic Scholar)
Sources: Crossref, Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Plum and Soy Aglycon Extracts Superior at Increasing Bone Calcium Retention in Ovariectomized Sprague Dawley Rats

Journal of Agricultural and Food Chemistry, 62(26), 6108–6117.

By: J. Pawlowski*, B. Martin*, G. McCabe*, M. Ferruzzi* & C. Weaver*

author keywords: genistein aglycon; genistein glucoside; bone calcium retention; bone resorption; plant-derived polyphenols
MeSH headings : Animals; Bone Density Conservation Agents / chemistry; Bone Density Conservation Agents / therapeutic use; Dietary Supplements; Female; Fruit / chemistry; Genistein / chemistry; Genistein / therapeutic use; Glucosides / chemistry; Glucosides / therapeutic use; Humans; Hydrolysis; Osteoporosis, Postmenopausal / diet therapy; Plant Extracts / chemistry; Plant Extracts / therapeutic use; Prunus / chemistry; Random Allocation; Rats, Sprague-Dawley; Seeds / chemistry; Soybeans / chemistry
TL;DR: Several polyphenolic-rich diets improved bone calcium retention, and supplementation of two doses each of blueberry, plum, grape, grape seed extract, and resveratrol on bone benefited both bone turnover and bone properties in the estrogen-depleted state. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2014 journal article

Stability–activity of verbascoside, a known antioxidant compound, at different pH conditions

Food Research International, 66, 373–378.

author keywords: OMWW; Human intestinal cell lines; Bioaccessibility; Antioxidant activity; Isobologram; Uptake
TL;DR: The antioxidant activity of VB can be modified by the conditions present in intestinal environment, as reported for other polyphenols. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2014 journal article

The effect of milk proteins on the bioaccessibility of green tea flavan-3-ols

Food Research International, 66, 297–305.

By: S. Moser*, M. Chegeni*, O. Jones*, A. Liceaga* & M. Ferruzzi*

author keywords: Bioaccessibility; Green tea; Flavan-3-ol; Milk Protein; SDS-PAGE; Fluorometry
Source: Crossref
Added: August 28, 2020

2014 journal article

Unsaturated fatty acids promote bioaccessibility and basolateral secretion of carotenoids and α-tocopherol by Caco-2 cells

Food Funct., 5(6), 1101–1112.

By: M. Failla*, C. Chitchumronchokchai*, M. Ferruzzi*, S. Goltz* & W. Campbell*

MeSH headings : Biological Availability; Butter; Caco-2 Cells; Carotenoids / metabolism; Carotenoids / pharmacokinetics; Chylomicrons / metabolism; Dietary Fats / pharmacology; Fatty Acids, Monounsaturated / pharmacology; Fatty Acids, Unsaturated / pharmacology; Humans; Lutein / metabolism; Micelles; Olive Oil; Plant Oils / pharmacology; Rapeseed Oil; Soybean Oil / pharmacology; Triglycerides / metabolism; alpha-Tocopherol / pharmacokinetics
TL;DR: It is suggested that dietary fats/oils rich in unsaturated fatty acids promote carotenoid and α-TC bioavailability by enhancing their micellarization during digestion and intestinal transport. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: August 28, 2020

2013 journal article

Assessment of phytochemical content in human milk during different stages of lactation

Nutrition, 29(1), 195–202.

By: B. Song*, Z. Jouni* & M. Ferruzzi*

author keywords: Flavonoid; Carotenoid; Flavan-3-ols; Flavanones; Flavonols
MeSH headings : Adult; Carotenoids / analysis; Catechin / analogs & derivatives; Catechin / analysis; Cryptoxanthins; Female; Flavanones / analysis; Flavonoids / analysis; Hesperidin / analysis; Humans; Kaempferols / analysis; Lactation / metabolism; Lutein / analysis; Lycopene; Milk, Human / chemistry; Postpartum Period / metabolism; Pregnancy; Quercetin / analysis; Time Factors; Xanthophylls / analysis; Zeaxanthins
TL;DR: The notion that flavonoids, as with carotenoids, are dietary phytochemicals present in human milk and potentially available to breast-fed infants is supported. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2013 journal article

Assessment of probiotic strains ability to reduce the bioaccessibility of aflatoxin M1 in artificially contaminated milk using an in vitro digestive model

Food Control, 31(1), 202–207.

By: J. Serrano-Niño*, A. Cavazos-Garduño*, A. Hernandez-Mendoza*, B. Applegate*, M. Ferruzzi*, M. San Martin-González*, H. García*

author keywords: Aflatoxin M-1; Probiotic bacteria; Binding; Bioaccessibility
TL;DR: The results of this work suggest that the probiotic strains tested could help to reduce harmful effects of AFM 1 to humans exposed to the aflatoxin through consumption of contaminated milk and/or dairy products. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2013 journal article

Assessment of verbascoside absorption in human colonic tissues using the Ussing chamber model

Food Research International, 54(1), 132–138.

author keywords: Bioavailability; Human tissues; Permeability coefficient; Ussing chamber; Verbascoside
TL;DR: The permeability coefficient calculation has contributed in a deeper understanding of VB absorption and transport across the human intestinal barrier and could be utilized for other polyphenols present in food and in dietary supplements. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Crossref
Added: August 28, 2020

2013 journal article

Bioaccessibility of Carotenoids from Transgenic Provitamin A Biofortified Sorghum

Journal of Agricultural and Food Chemistry, 61(24), 5764–5771.

By: T. Lipkie*, F. De Moura*, Z. Zhao*, M. Albertsen*, P. Che*, K. Glassman*, M. Ferruzzi*

author keywords: provitamin A; carotenoids; beta-carotene; biofortification; bioaccessibility; sorghum; in vitro digestion; micellarization
MeSH headings : Carotenoids / analysis; Carotenoids / metabolism; Cooking; Dietary Fats / metabolism; Digestion; Fatty Acids, Monounsaturated / metabolism; Food Handling; Humans; Micelles; Models, Biological; Nutritive Value; Plants, Genetically Modified / chemistry; Rapeseed Oil; Seeds / chemistry; Seeds / genetics; Seeds / metabolism; Sorghum / chemistry; Sorghum / genetics; Sorghum / metabolism; Vitamin A / analysis; Vitamin A / biosynthesis; Vitamin A / metabolism
TL;DR: The notion that biofortification of sorghum can enhance total and bioaccessible provitamin A carotenoid levels is supported, using an in vitro digestion model to screen vectors and independent transgenic events for the bioaccessibility of prov vitamin ACarotenoids. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2013 journal article

Carotenoid bioavailability from raw vegetables and a moderate amount of oil in human subjects is greatest when the majority of daily vegetables are consumed at one meal

Nutrition Research, 33(5), 358–366.

By: S. Goltz*, T. Sapper*, M. Failla*, W. Campbell* & M. Ferruzzi*

author keywords: Carotenoid; Bioavailability; Postprandial absorption; Meal patterns; Clinical trial; Human
MeSH headings : Adult; Antioxidants / administration & dosage; Antioxidants / pharmacokinetics; Area Under Curve; Biological Availability; Carotenoids / blood; Carotenoids / pharmacokinetics; Chromatography, Liquid; Fatty Acids, Monounsaturated; Feeding Behavior; Humans; Male; Meals; Pilot Projects; Postprandial Period / drug effects; Rapeseed Oil; Triglycerides / blood; Vegetables / chemistry; Young Adult
TL;DR: Data suggest that carotenoid absorption may be the greatest when daily recommended vegetables are consumed in one meal compared to smaller doses over multiple meals. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2013 journal article

Color and chemical stability of tea polyphenol (−)-epigallocatechin-3-gallate in solution and solid states

Food Research International, 53(2), 909–921.

By: N. Li*, L. Taylor*, M. Ferruzzi* & L. Mauer*

author keywords: Stability; EGCG; Theasinensin; GCG; Epimerization; Oxidation; Solid state; Color
Source: Crossref
Added: August 28, 2020

2013 journal article

Dietary fat increases quercetin bioavailability in overweight adults

Molecular Nutrition & Food Research, 57(5), 896–905.

By: Y. Guo*, E. Mah*, C. Davis*, T. Jalili*, M. Ferruzzi*, O. Chun*, R. Bruno*

author keywords: Fat; Micellarization efficiency; Obesity; Pharmacokinetics; Quercetin
MeSH headings : Area Under Curve; Biological Availability; Biomarkers / blood; Body Mass Index; Chromatography, High Pressure Liquid; Cross-Over Studies; Dietary Fats / administration & dosage; Disaccharides / blood; Disaccharides / pharmacokinetics; Female; Humans; Inflammation / blood; Inflammation / physiopathology; Linear Models; Male; Middle Aged; Overweight / blood; Overweight / complications; Overweight / physiopathology; Oxidative Stress / drug effects; Quercetin / analogs & derivatives; Quercetin / blood; Quercetin / pharmacokinetics
TL;DR: Dietary fat improves quercetin bioavailability by increasing its absorption, likely by enhancing its micellarization at the small intestine, according to a cross-over study on overweight/obese men and postmenopausal women. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2013 journal article

Microbial metabolites, but not other phenolics derived from grape seed phenolic extract, are transported through differentiated Caco-2 cell monolayers

Food Chemistry, 138(2-3), 1564–1573.

By: D. Wang*, B. Williams*, M. Ferruzzi* & B. D’Arcy*

author keywords: Grape seed extract; In vitro digestion; Caco-2 cell; Microbiota metabolites; LC-MS
MeSH headings : Bacteria / metabolism; Biological Transport; Caco-2 Cells; Cell Differentiation; Digestion; Grape Seed Extract / analysis; Grape Seed Extract / metabolism; Humans; Intestinal Mucosa / metabolism; Intestines / chemistry; Intestines / cytology; Intestines / microbiology; Metagenome; Models, Biological; Phenols / analysis; Phenols / metabolism; Stomach / physiology; Vitis / chemistry; Vitis / metabolism
TL;DR: Qualitatively, there was no change in type/number of GSE compounds following gastric and pancreatic digestion and LC-MS analysis, but the monomers were significantly increased after gastric digestion, along with a significant decrease in polymers. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2013 journal article

Photo- and Thermodegradation of Anthocyanins from Grape and Purple Sweet Potato in Model Beverage Systems

Journal of Agricultural and Food Chemistry, 61(6), 1364–1372.

By: B. Song*, T. Sapper*, C. Burtch*, K. Brimmer*, M. Goldschmidt* & M. Ferruzzi*

author keywords: acylated anthocyanin; light; heat; kinetics; ascorbic acid
MeSH headings : Anthocyanins / chemistry; Beverages / analysis; Beverages / radiation effects; Hot Temperature; Ipomoea batatas / chemistry; Kinetics; Models, Chemical; Vitis / chemistry
TL;DR: Anthocyanin-rich grape and purple sweet potato extracts to photo- and thermostresses in ready-to-drink (RTD) beverage models including hot fill beverages with various concentrations of ascorbic acid, a preserved beverage, and a vitamin-enriched water beverage found PSP was significantly less stable than grape extract in the vitamin- enriched water model beverage through photostress. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Crossref
Added: August 28, 2020

2013 journal article

Quantification of vitamin D and 25-hydroxyvitamin D in soft tissues by liquid chromatography–tandem mass spectrometry

Journal of Chromatography B, 932, 6–11.

By: T. Lipkie, A. Janasch, B. Cooper, E. Hohman*, C. Weaver* & M. Ferruzzi*

author keywords: 25-Hydroxyvitamin D analysis; Vitamin D analysis; Ergocalciferol; Cholecalciferol; Tissue distribution; LC-MS/MS
MeSH headings : Adipose Tissue / chemistry; Animals; Chromatography, Liquid / methods; Epididymis / chemistry; Liquid-Liquid Extraction; Liver / chemistry; Male; Muscles / chemistry; Rats; Rats, Sprague-Dawley; Solid Phase Extraction; Tandem Mass Spectrometry / methods; Vitamin D / analogs & derivatives; Vitamin D / analysis; Vitamin D / blood
TL;DR: Soft tissues of rats feeding crystalline vitamin D3 had higher concentrations of total vitamin D than those of rats fed yeast-derived vitamin D2, while total 25(OH)D concentrations were similar between vitamin D sources. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2013 journal article

Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model

Molecular Nutrition & Food Research, 57(12), 2091–2102.

By: J. Wang*, C. Tang*, M. Ferruzzi*, B. Gong*, B. Song*, E. Janle*, T. Chen*, B. Cooper* ...

author keywords: Metabolic syndrome; Polyphenols; Standardized grape polyphenol preparation; Synaptic plasticity
MeSH headings : Animals; Biological Availability; Brain / drug effects; Brain / physiopathology; Dietary Fats / pharmacology; Disease Models, Animal; Female; Grape Seed Extract / pharmacology; Male; Metabolic Syndrome / diet therapy; Metabolic Syndrome / drug therapy; Mice; Mice, Inbred C57BL; Neuronal Plasticity / drug effects; Polyphenols / pharmacokinetics; Polyphenols / pharmacology; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes / pharmacology; Synapses / drug effects; Vitis / chemistry
TL;DR: This study demonstrated that SGP, comprised of multiple bioavailable and bioactive components targeting a wide range of metabolic syndrome related pathological features, provides greater global protection against peripheral and central nervous system dysfunctions and can be potentially developed as a novel prevention/treatment for improving brain connectivity and synaptic plasticity important for learning and memory. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: January 21, 2021

2012 journal article

Different concentrations of grape seed extract affectin vitrostarch fermentation by porcine small and large intestinal inocula

Journal of the Science of Food and Agriculture, 93(2), 276–283.

By: D. Wang*, B. Williams*, M. Ferruzzi* & B. D'Arcy*

author keywords: Grape seed extract; pig; intestinal microbiota; in vitro fermentation; short-chain fatty acids; cumulative gas production; ammonia
MeSH headings : Ammonia / metabolism; Animals; Dietary Supplements; Fatty Acids, Volatile / metabolism; Feces / microbiology; Fermentation; Gastrointestinal Agents / metabolism; Gram-Negative Bacteria / isolation & purification; Gram-Negative Bacteria / metabolism; Gram-Positive Bacteria / isolation & purification; Gram-Positive Bacteria / metabolism; Grape Seed Extract / metabolism; Ileum / microbiology; Intestine, Large / microbiology; Intestine, Small / microbiology; Kinetics; Queensland; Seeds / chemistry; Starch / metabolism; Sus scrofa / microbiology; Vitis / chemistry
TL;DR: It is shown that GSE phenolics at a concentration over 250 µg ml⁻¹ can have measurable effects on microbial activity in an in vitro fermentation system, as evidenced by the changes in kinetics and end-products from starch fermentation. (via Semantic Scholar)
Source: Crossref
Added: January 24, 2021

2012 journal article

Does flavor impact function? Potential consequences of polyphenol–protein interactions in delivery and bioactivity of flavan-3-ols from foods

Physiology & Behavior, 107(4), 591–597.

By: M. Ferruzzi*, N. Bordenave* & B. Hamaker*

author keywords: Polyphenols; Proteins; Astringency; Binding; Flavan-3-ols; Bioaccessibility; Bioavailability
MeSH headings : Astringents / metabolism; Biological Availability; Digestive System / drug effects; Digestive System / enzymology; Enzyme Inhibitors / pharmacokinetics; Enzyme Inhibitors / pharmacology; Flavonoids / chemistry; Flavonoids / pharmacokinetics; Flavonoids / pharmacology; Humans; Molecular Structure; Polyphenols / chemistry; Polyphenols / pharmacokinetics; Polyphenols / pharmacology; Protein Binding; Proteins / metabolism; Taste
TL;DR: The physiological implications of these interactions in food and through the gut will be discussed in relation to manipulation of flavan-3-ol bioavailability, metabolism and biological activities including inhibition of digestive enzymes in the gut. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: August 28, 2020

2012 journal article

Effect of a flash vacuum expansion process on grape juice yield and quality

LWT - Food Science and Technology, 48(2), 147–155.

By: S. Paranjpe*, M. Ferruzzi* & M. Morgan*

author keywords: Flash vacuum expansion; Pectinase; Grape juice quality; Juice yield; Polyphenols
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Crossref
Added: August 28, 2020

2012 journal article

Enzymatic synthesis of substituted epicatechins for bioactivity studies in neurological disorders

Biochemical and Biophysical Research Communications, 417(1), 457–461.

By: J. Blount*, M. Ferruzzi*, D. Raftery*, G. Pasinetti* & R. Dixon*

author keywords: Alzheimer's disease; Grape seed extract; Polyphenols; Glucuronosyl transferase; Epicatechin glucuronides
MeSH headings : Alzheimer Disease / blood; Alzheimer Disease / metabolism; Animals; Catechin / analogs & derivatives; Catechin / biosynthesis; Catechin / chemistry; Catechin / isolation & purification; Chromatography, High Pressure Liquid; Glucuronates / biosynthesis; Glucuronates / chemistry; Glucuronates / isolation & purification; Glucuronosyltransferase / chemistry; Humans; Mice; Proanthocyanidins / biosynthesis; Proanthocyanidins / blood; Proanthocyanidins / chemistry; Recombinant Proteins / chemistry; UDP-Glucuronosyltransferase 1A9
TL;DR: These studies form a basis for generation of mg quantities of pure epicatechin (methyl) glucuronides of biological significance, and provide clarification of structure of previously identified epicateschin metabolites. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2012 journal article

Kinetic Study of Catechin Stability: Effects of pH, Concentration, and Temperature

Journal of Agricultural and Food Chemistry, 60(51), 12531–12539.

By: N. Li*, L. Taylor*, M. Ferruzzi* & L. Mauer*

author keywords: EGCG; stability; pH; kinetic model; shelf life; tea
MeSH headings : Catechin / analogs & derivatives; Catechin / chemistry; Drug Stability; Food Preservation; Hydrogen-Ion Concentration; Kinetics; Solutions / chemistry; Tea / chemistry; Temperature
TL;DR: An empirical model for catechin content was established as a function of pH and temperature and showed good correlation between green tea concentrated solutions and previous reports of catechine stability in powder systems, providing useful approaches for shelf life calculations and catechchin loss predictions at given temperature and pH conditions in green tea concentrates. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2012 journal article

Meal triacylglycerol profile modulates postprandial absorption of carotenoids in humans

Molecular Nutrition & Food Research, 56(6), 866–877.

By: S. Goltz*, W. Campbell*, C. Chitchumroonchokchai*, M. Failla* & M. Ferruzzi*

author keywords: Bioavailability; Carotenoids; Clinical trial; Dietary triacylglycerol; Postprandial absorption
MeSH headings : Adolescent; Adult; Butter; Carotenoids / administration & dosage; Carotenoids / blood; Carotenoids / metabolism; Cross-Over Studies; Diet, High-Fat; Fatty Acids, Monounsaturated / administration & dosage; Female; Humans; Intestinal Absorption; Lutein / administration & dosage; Lutein / blood; Lutein / metabolism; Male; Middle Aged; Nutritive Value; Postprandial Period; Rapeseed Oil; Soybean Oil / administration & dosage; Triglycerides / administration & dosage; Triglycerides / blood; Vegetables / chemistry; Young Adult
TL;DR: While both amount and source of co-consumed lipid affect carotenoid bioavailability from vegetables, amount appears to exert a stronger effect. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2012 journal article

P3-342: Intranasal delivery of bioactive polyphenol metabolites to prevent and/or treat Alzheimer's disease and other forms of dementia

Alzheimer's & Dementia, 8(4S_Part_16), P577–P577.

By: L. Knable*, P. Vempati*, D. Freire*, M. Ferruzzi* & G. Pasinetti*

Source: Crossref
Added: August 16, 2021

2012 journal article

Quantification of anthocyanidins in the grapes and grape juice products with acid assisted hydrolysis using LC/MS

Journal of Functional Foods, 4(4), 710–717.

By: Y. Xu*, J. Simon*, M. Ferruzzi*, L. Ho*, G. Pasinetti* & Q. Wu*

author keywords: Grape; LC-MS; Polyphenols; Anthocyanins; Anthocyanidins; Acidic hydrolysis
Source: Crossref
Added: August 28, 2020

2011 journal article

Beverage vs. Solid Fruits and Vegetables: Effects on Energy Intake and Body Weight

Obesity, 20(9), 1844–1850.

By: J. Houchins*, J. Burgess*, W. Campbell*, J. Daniel*, M. Ferruzzi*, G. McCabe*, R. Mattes*

MeSH headings : Adolescent; Adult; Analysis of Variance; Beverages; Eating; Energy Intake; Energy Metabolism; Female; Fruit; Humans; Indiana / epidemiology; Male; Nutritive Value; Obesity / epidemiology; Obesity / metabolism; Surveys and Questionnaires; Thinness / epidemiology; Thinness / metabolism; Vegetables; Weight Gain; Young Adult
TL;DR: Energy consumed as beverages may be especially problematic for weight gain and advice to increase fruit and vegetable consumption should emphasize total energy intake because the additional energy contributed may promote weight gain, especially among overweight and obese individuals. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2011 journal article

Carotenoid bioaccessibility from whole grain and decorticated yellow endosperm sorghum porridge

Journal of Cereal Science, 54(3), 450–459.

By: E. Kean*, N. Bordenave*, G. Ejeta*, B. Hamaker* & M. Ferruzzi*

author keywords: Sorghum; Carotenoids; In vitro digestion; Bioaccessibility
TL;DR: The effects of agronomic manipulation on sorghum carotenoid contents at selected stages of kernel development and maturation are explored and bioaccessibility from matured yellow-endosperm Sorghum varieties (P88 and P1222) is assessed, by comparing porridge made from sorghums whole and decorticated milled grains. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2011 journal article

Deliquescence Behavior and Chemical Stability of Vitamin C Forms (Ascorbic Acid, Sodium Ascorbate, and Calcium Ascorbate) and Blends

International Journal of Food Properties, 14(6), 1330–1348.

By: A. Hiatt*, M. Ferruzzi*, L. Taylor* & L. Mauer*

author keywords: Vitamin C; Deliquescence; Solubility; Stability
Source: Crossref
Added: August 28, 2020

2011 journal article

Modification of Curcumin with Polyethylene Glycol Enhances the Delivery of Curcumin in Preadipocytes and Its Antiadipogenic Property

Journal of Agricultural and Food Chemistry, 59(3), 1012–1019.

By: C. Kim*, N. Bordenave*, M. Ferruzzi*, A. Safavy* & K. Kim*

author keywords: Curcumin; polyethylene glycol; solubility; bioavailability; 3T3-L1; adipogenesis
MeSH headings : 3T3-L1 Cells; Adipocytes / metabolism; Adipogenesis / drug effects; Animals; Curcumin / chemistry; Curcumin / metabolism; Curcumin / pharmacology; Mice; Polyethylene Glycols / chemistry; Polyethylene Glycols / metabolism; Solubility; Water
TL;DR: Pgylation-improved water solubility and cellular retention ofCCM may be uniquely useful for improving the delivery of CCM in preadipocytes and its antiadipogenic ability. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Crossref
Added: August 28, 2020

2011 journal article

Neuroprotective and metabolic effects of resveratrol: Therapeutic implications for Huntington's disease and other neurodegenerative disorders

Experimental Neurology, 232(1), 1–6.

By: G. Pasinetti*, J. Wang*, P. Marambaud*, M. Ferruzzi*, P. Gregor*, L. Knable*, L. Ho*

MeSH headings : Animals; Disease Models, Animal; Huntington Disease / drug therapy; Huntington Disease / metabolism; Stilbenes / pharmacology; Stilbenes / therapeutic use
TL;DR: A recent study examined the therapeutic potential of a micronised proprietary resveratrol formulation, SRT501 in the N171-82Q transgenic mouse model of Huntington's disease, finding that SRT 501 treatment did not lead to significant improvement in weight loss, motor performance, survival and striatal atrophy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2011 journal article

Survey of Polyphenol Constituents in Grapes and Grape-Derived Products

Journal of Agricultural and Food Chemistry, 59(19), 10586–10593.

By: Y. Xu*, J. Simon*, C. Welch, J. Wightman*, M. Ferruzzi*, L. Ho*, G. Passinetti, Q. Wu*

author keywords: grape; LC-MS; polyphenols; anthocyanins; flavonoids; proanthocyanidin; phenolic acid
MeSH headings : Anthocyanins / analysis; Beverages / analysis; Chromatography, High Pressure Liquid; Flavonoids / analysis; Fruit / chemistry; Hydroxybenzoates / analysis; Mass Spectrometry; Polyphenols / analysis; Seeds / chemistry; Vitis / chemistry; Wine / analysis
TL;DR: A rapid and comprehensive qualitative method has been developed to characterize the different classes of polyphenols, such as anthocyanins, flavonols, phenolic acids, and flavanols/proanthocyanidins in grape products. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2010 journal article

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

Journal of Biological Chemistry, 285(12), 9100–9113.

By: V. Vingtdeux*, L. Giliberto*, H. Zhao*, P. Chandakkar*, Q. Wu*, J. Simon*, E. Janle*, J. Lobo* ...

MeSH headings : AMP-Activated Protein Kinases / metabolism; Alzheimer Disease / metabolism; Amyloid beta-Peptides / chemistry; Animals; Autophagy; Calcium / metabolism; Cytosol / metabolism; Enzyme Inhibitors / pharmacology; Humans; Lysosomes / metabolism; Male; Mice; Mice, Transgenic; Neurons / metabolism; Resveratrol; Signal Transduction; Stilbenes / pharmacology
TL;DR: It is shown that AMPK signaling controls Aβ metabolism and mediates the anti-amyloidogenic effect of resveratrol in non-neuronal and neuronal cells, including in mouse primary neurons, and that resver atrol and pharmacological activation of AMPK have therapeutic potential against Alzheimer disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2010 journal article

Chocolate Matrix Factors Modulate the Pharmacokinetic Behavior of Cocoa Flavan-3-ol Phase II Metabolites Following Oral Consumption by Sprague−Dawley Rats

Journal of Agricultural and Food Chemistry, 58(11), 6685–6691.

By: A. Neilson, T. Sapper, E. Janle, R. Rudolph, N. Matusheski* & M. Ferruzzi*

author keywords: Bioavailability; chocolate; flavan-3-ols; epicatechin; phase II metabolism; Sprague-Dawley rat
MeSH headings : Administration, Oral; Animals; Cocos / chemistry; Flavonoids / administration & dosage; Flavonoids / metabolism; Flavonoids / pharmacokinetics; Male; Plant Extracts / administration & dosage; Plant Extracts / metabolism; Plant Extracts / pharmacokinetics; Rats; Rats, Sprague-Dawley
TL;DR: Milk and sucrose appear to modulate both metabolism and plasma pharmacokinetics and, to a lesser extent, the overall bioavailability of catechins from chocolate confections. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2010 journal article

Development and optimization of an LC-MS/MS-based method for simultaneous quantification of vitamin D2, vitamin D3, 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3

Journal of Separation Science, 34(1), 11–20.

By: J. Adamec*, A. Jannasch*, J. Huang*, E. Hohman*, J. Fleet*, M. Peacock*, M. Ferruzzi*, B. Martin*, C. Weaver*

author keywords: Cholecalciferol; Ergocalciferol; LC-MS/MS; Vitamin D
MeSH headings : 25-Hydroxyvitamin D 2 / analysis; Calcifediol / analysis; Cholecalciferol / analysis; Chromatography, Liquid / instrumentation; Chromatography, Liquid / methods; Chromatography, Liquid / standards; Ergocalciferols / analysis; Humans; Molecular Structure; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry / instrumentation; Tandem Mass Spectrometry / methods; Tandem Mass Spectrometry / standards
TL;DR: A sensitive and reproducible method is reported for simultaneous quantification of vitamin D (2) , vitamin D(3) , 25-hydroxyvitamin D(2) and 25- Hydroxylated molecules in biological samples. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2010 journal article

Formulation with ascorbic acid and sucrose modulates catechin bioavailability from green tea

Food Research International, 43(1), 95–102.

By: C. Peters*, R. Green*, E. Janle* & M. Ferruzzi*

author keywords: Bioavailability; Caco-2; Catechin; In vitro digestion; Green tea; Sprague Dawley
TL;DR: It is suggested that formulation with sucrose and ascorbic acid may improve catechin bioavailability by enhancing bioaccessibility and intestinal uptake from tea. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2010 journal article

Green and Black Tea Inhibit Cytokine-Induced Il-8 Production and Secretion in AGS Gastric Cancer Cells via Inhibition of NF-κB Activity

Planta Medica, 76(15), 1659–1665.

By: F. Gutierrez-Orozco*, B. Stephens*, A. Neilson*, R. Green*, M. Ferruzzi* & J. Bomser*

author keywords: black tea; inflammation; gastric cancer; epigallocatechin gallate; green tea
MeSH headings : Camellia sinensis / chemistry; Catechin / analogs & derivatives; Catechin / chemistry; Catechin / pharmacology; Cell Line, Tumor; Chromatography, Liquid; Humans; Interleukin-1beta / pharmacology; Interleukin-8 / metabolism; MAP Kinase Signaling System / drug effects; Mass Spectrometry; NF-kappa B / metabolism; Plant Extracts / chemistry; Plant Extracts / pharmacology; Stomach Neoplasms / metabolism; Tea / chemistry
Source: Crossref
Added: August 28, 2020

2010 journal article

P2-317: Resveratrol lowers beta-amyloid accumulation and deposition in vivo by controlling AMPK signaling

Alzheimer's & Dementia, 6, S406–S406.

By: P. Marambaud*, V. Vingtdeux*, L. Giliberto*, H. Zhao*, P. Chandakkar*, Q. Wu*, J. Simon*, E. Janle* ...

Source: Crossref
Added: August 16, 2021

2010 journal article

Tea catechin auto-oxidation dimers are accumulated and retained by Caco-2 human intestinal cells

Nutrition Research, 30(5), 327–340.

By: A. Neilson*, B. Song*, T. Sapper*, J. Bomser* & M. Ferruzzi*

author keywords: Catechins; Epicatechins; Auto-oxidation; Tea; Dimers; Theasinensin; P-2; Caco-2
MeSH headings : Benzopyrans / chemistry; Benzopyrans / metabolism; Caco-2 Cells; Camellia sinensis / chemistry; Catechin / analogs & derivatives; Catechin / chemistry; Catechin / metabolism; Chromatography, Liquid; Dimerization; Epithelial Cells / metabolism; Humans; Intestinal Absorption; Intestinal Mucosa / metabolism; Mass Spectrometry; Oxidation-Reduction; Phenols / chemistry; Phenols / metabolism; Polymers / chemistry; Polymers / metabolism; Tea / chemistry
TL;DR: Data suggest that catechin dimers present in the gut lumen may be readily absorbed by intestinal epithelium, suggesting intracellular oxidative conversion of THSNs to P-2. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2010 journal article

The influence of beverage composition on delivery of phenolic compounds from coffee and tea

Physiology & Behavior, 100(1), 33–41.

By: M. Ferruzzi*

author keywords: Tea; Coffee; Bioaccessibility; Bioavailability; Food matrix; Catechins; Phenolics
MeSH headings : Beverages; Biological Availability; Catechin / pharmacokinetics; Chlorogenic Acid / pharmacokinetics; Coffee / chemistry; Flavonoids / chemistry; Flavonoids / metabolism; Flavonoids / pharmacology; Humans; Models, Biological; Phenols / chemistry; Phenols / metabolism; Phenols / pharmacology; Polyphenols; Tea / chemistry
TL;DR: An overview of the phenolic composition of coffee and tea is discussed in the context of how processing and composition might influence phenolic profiles and bioavailability of individual phenolic components. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 16, 2021

2009 journal article

C1 Régulation des taux cérébraux de peptide Aß par l’AMP kinase

Revue Neurologique, 165(10), 19.

By: V. Vingtdeux*, H. Zhao*, P. Chandakkar*, Q. Wu*, J. Simon*, E. Janle*, J. Lobo*, M. Ferruzzi*, P. Davies*, P. Marambaud*

Source: Crossref
Added: August 28, 2020

2009 journal article

Impact of phytochemical-rich foods on bioaccessibility of mercury from fish

Food Chemistry, 112(1), 46–50.

By: S. Shim*, M. Ferruzzi*, Y. Kim*, E. Janle* & C. Santerre*

author keywords: mercury; bioaccessibility; phytochemical; in vitro digestion
Source: Crossref
Added: August 28, 2020

2009 journal article

Influence of Chocolate Matrix Composition on Cocoa Flavan-3-ol Bioaccessibility In Vitro and Bioavailability in Humans

Journal of Agricultural and Food Chemistry, 57(20), 9418–9426.

By: A. Neilson, J. George, E. Janle, R. Mattes, R. Rudolph, N. Matusheski, M. Ferruzzi*

author keywords: Theobroma cacao; food matrix; chocolate; catechin; epicatechin; bioavailability; in vitro digestion; Caco-2 cells
MeSH headings : Beverages / analysis; Biological Availability; Cacao / chemistry; Caco-2 Cells; Candy / analysis; Cross-Over Studies; Female; Flavonoids / administration & dosage; Flavonoids / blood; Flavonoids / pharmacokinetics; Humans; Male; Milk Proteins / analysis; Plant Extracts / administration & dosage; Plant Extracts / blood; Plant Extracts / pharmacokinetics; Young Adult
TL;DR: The data suggest that bioavailability of cocoa flavan-3-ols is likely similar from typical commercial cocoa based foods and beverages, but that the physical form and sucrose content may influence T(MAX) and C(MAX). (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2009 journal article

Research highlights from the Purdue-UAB Botanicals Research Center for Age Related Diseases

Pharmaceutical Biology, 47(8), 768–773.

By: C. Weaver*, S. Barnes*, J. Wyss*, H. Kim*, D. Morré*, D. Morré*, J. Simon*, M. Lila*, E. Janle*, M. Ferruzzi*

author keywords: Botanicals; isoflavones; catechins; bone resorption; cognitive function; cancer
TL;DR: The Purdue-UAB Botanicals Research Center for Age Related Disease uses multidisciplinary and innovative technologies to investigate the bioavailability of bioactive polyphenolic constituents from botanicals and their relationship to human health. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020

2008 journal article

Carotenoid Bioaccessibility from Whole Grain and Degermed Maize Meal Products

Journal of Agricultural and Food Chemistry, 56(21), 9918–9926.

By: E. Kean*, B. Hamaker* & M. Ferruzzi*

author keywords: Carotenoids; maize; lutein; carotene; bread; porridge; bioaccessibility
MeSH headings : Biological Availability; Carotenoids / analysis; Food-Processing Industry; Lutein / analysis; Xanthophylls / analysis; Zea mays / chemistry; Zeaxanthins
TL;DR: The results suggest that maize-based food products are good dietary sources of bioaccessible carotenoids and that specific food preparation methods may influence the relative bioaccessibility of individual carotanoid species. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2008 journal article

Epigallocatechin-3-gallate (EGCG) inhibits PC-3 prostate cancer cell proliferation via MEK-independent ERK1/2 activation

Chemico-Biological Interactions, 171(1), 89–95.

By: D. Albrecht*, E. Clubbs*, M. Ferruzzi* & J. Bomser*

author keywords: epigallocatechin-3-gallate; extracellular signal-regulated kinase; prostate cancer; green tea
MeSH headings : Anticarcinogenic Agents / pharmacology; Catechin / analogs & derivatives; Catechin / pharmacology; Cell Line; Cell Line, Tumor; Cell Proliferation / drug effects; Chromones / pharmacology; Enzyme Activation / drug effects; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Flavonoids / pharmacology; Humans; Inhibitory Concentration 50; Male; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3 / metabolism; Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinase Kinases / metabolism; Morpholines / pharmacology; Phosphatidylinositol 3-Kinases / metabolism; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation / drug effects; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology; Protein Kinase Inhibitors / pharmacology
TL;DR: Results suggest that ERK1/2 activation via a MEK-independent, PI3-K-dependent signaling pathway is partially responsible for the antiproliferative effects of EGCG in PC-3 cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2008 journal article

Impact of Deliquescence on the Chemical Stability of Vitamins B1, B6, and C in Powder Blends

Journal of Agricultural and Food Chemistry, 56(15), 6471–6479.

By: A. Hiatt*, M. Ferruzzi*, L. Taylor* & L. Mauer*

author keywords: deliquescence; thiamin; pyridoxine; ascorbate; stability; humidity
MeSH headings : Adsorption; Ascorbic Acid / chemistry; Chromatography, High Pressure Liquid; Drug Stability; Humidity; Hydrogen-Ion Concentration; Pharmaceutical Preparations / chemistry; Powders / chemistry; Thiamine / chemistry; Vitamin B 6 / chemistry; Water / analysis
TL;DR: Formulation, storage conditions, and the relation of these to deliquescence points may affect the shelf life, quality, and functionality of vitamin blends and should be considered in product development, processing, storage, and use. (via Semantic Scholar)
Source: Crossref
Added: January 24, 2021

2008 journal article

Impact of the Hard-to-Cook Phenomenon on Phenolic Antioxidants in Dry Beans (Phaseolus vulgaris)

Journal of Agricultural and Food Chemistry, 56(9), 3102–3110.

By: C. Machado*, M. Ferruzzi* & S. Nielsen*

author keywords: common beans; Phaseolus vulgaris; phenolic acids; antioxidant activity; hard-to-cook phenomenon
MeSH headings : Antioxidants / analysis; Food Preservation; Food Technology; Hot Temperature; Hydroxybenzoates / analysis; Phaseolus / chemistry; Phenols / analysis; Seeds / chemistry; Time Factors
TL;DR: This study showed that the HTC phenomenon affected a potential nutritive characteristic of dry beans, and the contents of free and acid hydrolyzable phenolic acids were reduced and the antioxidant activity was reduced. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2008 journal article

Interaction of Environmental Moisture with Powdered Green Tea Formulations: Effect on Catechin Chemical Stability

Journal of Agricultural and Food Chemistry, 56(11), 4068–4077.

By: J. Ortiz*, M. Ferruzzi*, L. Taylor* & L. Mauer*

author keywords: green tea; catechin stability; degradation; powder; humidity
MeSH headings : Adsorption; Ascorbic Acid / chemistry; Catechin / chemistry; Drug Stability; Environment; Food Preservation; Humidity; Sodium Nitrite / pharmacology; Tea / chemistry
TL;DR: Results are the first to demonstrate that addition of other dry components to tea powders may affect catechin stability in finished dry blends and highlight the importance of considering the complex interplay between a multicomponent system and its environment for developing stable products. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2007 journal article

Catechin Degradation with Concurrent Formation of Homo- and Heterocatechin Dimers duringin VitroDigestion

Journal of Agricultural and Food Chemistry, 55(22), 8941–8949.

By: A. Neilson*, A. Hopf*, B. Cooper*, M. Pereira*, J. Bomser* & M. Ferruzzi*

author keywords: catechin; oxidation; digestion; dimer; theasinensin; P-2; gut; pH; HPLC; electrochemical detection; mass spectrometry
MeSH headings : Catechin / analogs & derivatives; Catechin / metabolism; Digestion; Dimerization; In Vitro Techniques; Lipase / metabolism; Oxidation-Reduction; Pancreatin / metabolism; Pepsin A / metabolism
TL;DR: This study provides an expanded profile of catechin dimers of digestive origin that may potentially form following consumption of catechins, and provides a logical basis for initial screening to detect cATEchin digestive products in vivo. (via Semantic Scholar)
Source: Crossref
Added: January 24, 2021

2007 journal article

Characterization of Carotenoid Pigments in Mature and Developing Kernels of Selected Yellow-Endosperm Sorghum Varieties

Journal of Agricultural and Food Chemistry, 55(7), 2619–2626.

By: E. Kean*, G. Ejeta*, B. Hamaker* & M. Ferruzzi*

author keywords: carotenoids; lutein; zeaxanthin; provitamin A; sorghum; maize; HPLC; cereals; development
MeSH headings : Carotenoids / analysis; Chromatography, High Pressure Liquid; Pigments, Biological / analysis; Seeds / chemistry; Sorghum / chemistry
TL;DR: The presence of genetic variation among sorghum cultivars for carotenoid accumulation in developing and mature kernels is suggested, suggesting a potential source of dietary phytochemicals includingcarotenoids including (all-E)-Beta-carotene. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2007 journal article

Common tea formulations modulatein vitro digestive recovery of green tea catechins

Molecular Nutrition & Food Research, 51(9), 1152–1162.

By: R. Green*, A. Murphy*, B. Schulz*, B. Watkins* & M. Ferruzzi*

author keywords: citrus juice; flavonoids; HPLC; milk; tea
MeSH headings : Animals; Beverages / analysis; Bile / metabolism; Catechin / analogs & derivatives; Catechin / analysis; Catechin / metabolism; Catechin / pharmacokinetics; Chromatography, High Pressure Liquid; Citrus / chemistry; Digestion; Drug Stability; Food Additives / pharmacology; Fruit / chemistry; Hydrogen-Ion Concentration; In Vitro Techniques; Lipase / metabolism; Milk / chemistry; Oryza / chemistry; Pancreatin / metabolism; Pepsin A / metabolism; Soy Milk / chemistry; Tea / chemistry
TL;DR: Evidence is provided that tea consumption practices and formulation factors likely impact catechin digestive recovery and may result in diverse physiological profiles. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2007 journal article

Dietary PUFA and flavonoids as deterrents for environmental pollutants

The Journal of Nutritional Biochemistry, 18(3), 196–205.

By: B. Watkins*, K. Hannon*, M. Ferruzzi* & Y. Li*

author keywords: omega-3 polyunsaturated fatty acids; flavonoids; heavy metals; inflammation; oxidative stress; polychlorinated biphenyls
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Coronary Disease / etiology; Dietary Fats, Unsaturated / pharmacology; Environmental Pollutants / antagonists & inhibitors; Fatty Acids, Omega-3 / pharmacology; Fatty Acids, Unsaturated / pharmacology; Flavonoids / pharmacology; Humans; Inflammation / complications; Lipid Metabolism; Metals, Heavy / toxicity; Oxidative Stress / physiology; Polychlorinated Biphenyls / antagonists & inhibitors; Polychlorinated Biphenyls / toxicity
TL;DR: The concept for studying food components that influence inflammation and how LC omega-3 PUFA and flavonoids could be used therapeutically against inflammation that is mediated by environmental pollutants is introduced. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2007 journal article

Digestion, absorption, and cancer preventative activity of dietary chlorophyll derivatives

Nutrition Research, 27(1), 1–12.

By: M. Ferruzzi* & J. Blakeslee*

author keywords: chlorophyll; chlorophyllin; cancer prevention; antimutagenic; antioxidant; xenobiotic metabolism; apoptosis; bioavailability
TL;DR: Investigation of the impact of digestive factors on chlorophyll structure and bioaccessibility is included to better understand the extent to which these pigments may be bioavailable in humans and therefore have more systemic impact in the prevention of cancer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2007 journal article

Effect of a Thermogenic Beverage on 24-Hour Energy Metabolism in Humans*

Obesity, 15(2), 349–355.

By: S. Rudelle*, M. Ferruzzi*, I. Cristiani*, J. Moulin*, K. Macé*, K. Acheson*, L. Tappy*

author keywords: 24-hour energy expenditure; fat oxidation; green tea; caffeine; epigallocatechin gallate
MeSH headings : Adolescent; Adult; Beverages; Catecholamines / urine; Cross-Over Studies; Double-Blind Method; Energy Metabolism / drug effects; Female; Humans; Male; Monitoring, Ambulatory; Placebos; Sympathetic Nervous System / drug effects; Sympathetic Nervous System / metabolism; Thermogenesis / drug effects
TL;DR: Testing whether consumption of a beverage containing active ingredients will increase 24‐hour energy metabolism in healthy, young, lean individuals finds it to be a good idea. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2007 journal article

Impact of Fatty Acyl Composition and Quantity of Triglycerides on Bioaccessibility of Dietary Carotenoids

Journal of Agricultural and Food Chemistry, 55(22), 8950–8957.

By: T. Huo*, M. Ferruzzi*, S. Schwartz