Works (8)

Updated: April 12th, 2024 05:00

2023 article

Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut

Foley, M. H., Walker, M. E., Stewart, A. K., O'Flaherty, S., Gentry, E. C., Patel, S., … Theriot, C. M. (2023, March 13). NATURE MICROBIOLOGY, Vol. 3.

By: M. Foley n, M. Walker*, A. Stewart n, S. O'Flaherty n, E. Gentry*, S. Patel*, V. Beaty*, G. Allen n ...

MeSH headings : Animals; Mice; Humans; Clostridioides difficile; Clostridioides; Bile Acids and Salts; Amidohydrolases; Clostridium Infections
TL;DR: Insight is provided into the structural basis of BSH mechanisms that shape the BA landscape and promote colonization resistance against C. difficile in vitro and in pre-clinical in vivo models of CDI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023

2023 journal article

Multiple TonB homologs are important for carbohydrate utilization by <i>Bacteroides thetaiotaomicron</i>


By: R. Pollet*, M. Foley*, S. Kumar*, A. Elmore*, N. Jabara*, S. Venkatesh*, G. Pereira*, E. Martens*, N. Koropatkin*

author keywords: TonB; TonB-dependent transporter; Bacteroides thetaiotaomicron; Bacteroidetes; polysaccharide utilization; starch; human gut microbiota
TL;DR: The role of 11 predicted TonB homologs in polysaccharide uptake is examined and two proteins, TonB4 and TonB6, may be functionally redundant, which may allow for the development of drugs targeting Bacteroides species containing only a TonB 4 homolog with limited impact on species encoding the redundant TonB 6. (via Semantic Scholar)
Source: Web Of Science
Added: November 13, 2023

2023 journal article

The microbial-derived bile acid lithocholate and its epimers inhibit <i>Clostridioides difficile</i> growth and pathogenicity while sparing members of the gut microbiota


By: S. Kisthardt n, R. Thanissery n, C. Pike n, M. Foley n & C. Theriot n

author keywords: lithocholate; Clostridioides difficile; epimers; secondary bile acids; gut microbiota
Source: Web Of Science
Added: April 8, 2024

2023 journal article

Using Multidimensional Separations to Distinguish Isomeric Amino Acid-Bile Acid Conjugates and Assess Their Presence and Perturbations in Model Systems

ANALYTICAL CHEMISTRY, 95(41), 15357–15366.

By: A. Stewart n, M. Foley n, M. Dougherty*, S. Mcgill*, A. Gulati*, E. Gentry*, L. Hagey*, P. Dorrestein* ...

TL;DR: This work analyzed 8 core bile acids synthetically conjugated with 22 proteinogenic and nonproteogenic amino acids totaling 176 MCBAs and created an in-house extended bile acid library that was applied to healthy mice dosed with antibiotics and humans having fecal microbiota transplantation (FMT) to assess the MCBA presence and changes in the gut before and after each perturbation. (via Semantic Scholar)
Source: Web Of Science
Added: October 30, 2023

2021 journal article

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota


MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacterial Toxins / genetics; Bacterial Toxins / immunology; Bacterial Toxins / metabolism; Bacteroides / drug effects; Bacteroides / metabolism; Clostridioides difficile / genetics; Clostridioides difficile / immunology; Clostridioides difficile / metabolism; Clostridium Infections / immunology; Clostridium Infections / microbiology; Clostridium Infections / pathology; Disease Models, Animal; Extracellular Matrix / metabolism; Female; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / immunology; Gene Expression Regulation, Bacterial / immunology; Host-Pathogen Interactions / genetics; Host-Pathogen Interactions / immunology; Humans; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Male; Matrix Metalloproteinases / metabolism; Mice; Nutrients / metabolism; Proteolysis; RNA, Bacterial / genetics; RNA, Bacterial / isolation & purification; RNA-Seq; Sigma Factor / genetics; Sigma Factor / immunology; Sigma Factor / metabolism; Transcriptome / immunology
TL;DR: Insight is provided into how toxin-induced inflammation alters C. difficile metabolism, host tissue gene expression and gut microbiota, together influencing a beneficial niche for infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 20, 2021

2021 journal article

Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization


By: M. Foley n, S. O'Flaherty n, G. Allen n, A. Rivera n, A. Stewart n, R. Barrangou n, C. Theriot n

author keywords: Lactobacillus; Acidophilus; gasseri; bile salt hydrolase; bile acid
MeSH headings : Amidohydrolases / genetics; Amidohydrolases / metabolism; Ecosystem; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Genetic Fitness / genetics; Host-Pathogen Interactions / genetics; Humans; Lactobacillus / enzymology; Lactobacillus / genetics; Probiotics / pharmacology; Substrate Specificity / genetics
TL;DR: It is shown that BA type and BSH substrate preferences affect in vitro and in vivo growth of both species and that BSH enzymatic preferences and the intrinsic chemical features of various BAs determine the toxicity of these molecules during Lactobacillus growth. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 2, 2021

2020 journal article

Simple Analysis of Primary and Secondary Bile Salt Hydrolysis in Mouse and Human Gut Microbiome Samples by Using Fluorogenic Substrates

CHEMBIOCHEM, 21(24), 3539–3543.

By: A. Sveistyte*, T. Gibbins*, K. Tyrrell*, C. Miller*, M. Foley n, A. Plymale*, A. Wright*, K. Brandvold*

author keywords: bile; chemical biology; fluorescence; gut microbiome; metabolism
MeSH headings : Animals; Bile Acids and Salts / chemical synthesis; Bile Acids and Salts / chemistry; Bile Acids and Salts / metabolism; Fluorescent Dyes / chemical synthesis; Fluorescent Dyes / chemistry; Fluorescent Dyes / metabolism; Gastrointestinal Microbiome; Humans; Hydrolysis; Mice; Molecular Conformation
TL;DR: The data demonstrate that most gut microbiomes have the highest capacity for hydrolysis of host‐produced primary bile salts, but some microbially modified secondary bile salt also display significant turnover. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 26, 2020

2019 journal article

Bile salt hydrolases: Gatekeepers of bile acid metabolism and host-microbiome crosstalk in the gastrointestinal tract


By: M. Foley n, S. O'Flaherty n, R. Barrangou n & C. Theriot n

Ed(s): L. Knoll

MeSH headings : Amidohydrolases / metabolism; Amidohydrolases / physiology; Bile Acids and Salts / metabolism; Gastrointestinal Microbiome / physiology; Gastrointestinal Tract; Host Microbial Interactions / physiology; Humans
TL;DR: Bile acids serve as substrates for bile acid receptors (BARs) found throughout the body that control critical regulatory and metabolic processes and therefore represent an important class of bioactive molecules, and there remain gaps in knowledge about the bacterial enzymes driving their composition and modification. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 15, 2019

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