Works (5)

Updated: July 9th, 2023 21:20

2023 article

Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut

Foley, M. H., Walker, M. E., Stewart, A. K., O'Flaherty, S., Gentry, E. C., Patel, S., … Theriot, C. M. (2023, March 13). NATURE MICROBIOLOGY, Vol. 3.

MeSH headings : Animals; Mice; Humans; Clostridioides difficile; Clostridioides; Bile Acids and Salts; Amidohydrolases; Clostridium Infections
Sources: Web Of Science, ORCID
Added: April 4, 2023

2021 journal article

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota


MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacterial Toxins / genetics; Bacterial Toxins / immunology; Bacterial Toxins / metabolism; Bacteroides / drug effects; Bacteroides / metabolism; Clostridioides difficile / genetics; Clostridioides difficile / immunology; Clostridioides difficile / metabolism; Clostridium Infections / immunology; Clostridium Infections / microbiology; Clostridium Infections / pathology; Disease Models, Animal; Extracellular Matrix / metabolism; Female; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / immunology; Gene Expression Regulation, Bacterial / immunology; Host-Pathogen Interactions / genetics; Host-Pathogen Interactions / immunology; Humans; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Male; Matrix Metalloproteinases / metabolism; Mice; Nutrients / metabolism; Proteolysis; RNA, Bacterial / genetics; RNA, Bacterial / isolation & purification; RNA-Seq; Sigma Factor / genetics; Sigma Factor / immunology; Sigma Factor / metabolism; Transcriptome / immunology
Sources: Web Of Science, ORCID
Added: January 20, 2021

2021 journal article

Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization


By: M. Foley n, S. O'Flaherty n, G. Allen n, A. Rivera n, A. Stewart n, R. Barrangou n, C. Theriot n

author keywords: Lactobacillus; Acidophilus; gasseri; bile salt hydrolase; bile acid
MeSH headings : Amidohydrolases / genetics; Amidohydrolases / metabolism; Ecosystem; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Genetic Fitness / genetics; Host-Pathogen Interactions / genetics; Humans; Lactobacillus / enzymology; Lactobacillus / genetics; Probiotics / pharmacology; Substrate Specificity / genetics
Sources: Web Of Science, ORCID
Added: February 2, 2021

2020 journal article

Simple Analysis of Primary and Secondary Bile Salt Hydrolysis in Mouse and Human Gut Microbiome Samples by Using Fluorogenic Substrates

CHEMBIOCHEM, 21(24), 3539–3543.

By: A. Sveistyte*, T. Gibbins*, K. Tyrrell*, C. Miller*, M. Foley n, A. Plymale*, A. Wright*, K. Brandvold*

author keywords: bile; chemical biology; fluorescence; gut microbiome; metabolism
MeSH headings : Animals; Bile Acids and Salts / chemical synthesis; Bile Acids and Salts / chemistry; Bile Acids and Salts / metabolism; Fluorescent Dyes / chemical synthesis; Fluorescent Dyes / chemistry; Fluorescent Dyes / metabolism; Gastrointestinal Microbiome; Humans; Hydrolysis; Mice; Molecular Conformation
Source: Web Of Science
Added: October 26, 2020

2019 journal article

Bile salt hydrolases: Gatekeepers of bile acid metabolism and host-microbiome crosstalk in the gastrointestinal tract


By: M. Foley*, S. O'Flaherty*, R. Barrangou* & C. Theriot*

Ed(s): L. Knoll

MeSH headings : Amidohydrolases / metabolism; Amidohydrolases / physiology; Bile Acids and Salts / metabolism; Gastrointestinal Microbiome / physiology; Gastrointestinal Tract; Host Microbial Interactions / physiology; Humans
Sources: Web Of Science, ORCID
Added: April 15, 2019