Matthew Foley

Works (9)

Updated: August 2nd, 2025 05:03

2025 article

Differential modulation of post-antibiotic colonization resistance to Clostridioides difficile by two probiotic Lactobacillus strains

Foley, M. H., McMillan, A. S., O'Flaherty, S., Thanissery, R., Vanhoy, M. E., Fuller, M. G., … Theriot, C. M. (2025, July 21). (J. Ravel, Ed.). MBio, Vol. 7.

By: M. Foley n, A. McMillan  n, S. O'Flaherty n, R. Thanissery  n, M. Vanhoy n, M. Fuller n, R. Barrangou n , C. Theriot n

Ed(s): J. Ravel

author keywords: microbiome; <italic>Lactobacillus</italic>; probiotic; <italic>Clostridioides difficile</italic>; colonization resistance; <italic>Muribaculaceae</italic>
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Gut microbiota and health; Probiotics and Fermented Foods
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 28, 2025

2023 article

Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut

Foley, M. H., Walker, M. E., Stewart, A. K., Sarah, O. F., Gentry, E. C., Patel, S., … Theriot, C. M. (2023, March 13). Nature Microbiology, Vol. 3.

By: M. Foley n, M. Walker *, A. Stewart n, O. Sarah n, E. Gentry *, S. Patel *, V. Beaty *, G. Allen n ...

MeSH headings : Animals; Mice; Humans; Clostridioides difficile; Clostridioides; Bile Acids and Salts; Amidohydrolases; Clostridium Infections
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Gut microbiota and health; Helicobacter pylori-related gastroenterology studies
TL;DR: Insight is provided into the structural basis of BSH mechanisms that shape the BA landscape and promote colonization resistance against C. difficile in vitro and in pre-clinical in vivo models of CDI. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023

2023 article

Multiple TonB homologs are important for carbohydrate utilization by Bacteroides thetaiotaomicron

Pollet, R. M., Foley, M. H., Kumar, S. S., Elmore, A., Jabara, N. T., Venkatesh, S., … Koropatkin, N. M. (2023, October 24). Journal of Bacteriology.

By: R. Pollet *, M. Foley*, S. Kumar*, A. Elmore*, N. Jabara*, S. Venkatesh*, G. Pereira *, E. Martens *, N. Koropatkin *

author keywords: TonB; TonB-dependent transporter; Bacteroides thetaiotaomicron; Bacteroidetes; polysaccharide utilization; starch; human gut microbiota
MeSH headings : Humans; Bacteroides thetaiotaomicron / metabolism; Polysaccharides / metabolism; Bacteroides / genetics
topics (OpenAlex): Genomics and Phylogenetic Studies; Bacterial Genetics and Biotechnology; Caveolin-1 and cellular processes
TL;DR: The role of 11 predicted TonB homologs in polysaccharide uptake is examined and two proteins, TonB4 and TonB6, may be functionally redundant, which may allow for the development of drugs targeting Bacteroides species containing only a TonB 4 homolog with limited impact on species encoding the redundant TonB 6. (via Semantic Scholar)
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Source: Web Of Science
Added: November 13, 2023

2023 article

The microbial-derived bile acid lithocholate and its epimers inhibit Clostridioides difficile growth and pathogenicity while sparing members of the gut microbiota

Kisthardt, S. C., Thanissery, R., Pike, C. M., Foley, M. H., & Theriot, C. M. (2023, September 11). Journal of Bacteriology.

By: S. Kisthardt n, R. Thanissery  n, C. Pike n, M. Foley n & C. Theriot n

author keywords: lithocholate; Clostridioides difficile; epimers; secondary bile acids; gut microbiota
MeSH headings : Humans; Virulence; Gastrointestinal Microbiome; Clostridioides difficile; Caco-2 Cells; Bile Acids and Salts / pharmacology; Lithocholic Acid
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Gut microbiota and health; Gastrointestinal motility and disorders
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Source: Web Of Science
Added: April 8, 2024

2023 article

Using Multidimensional Separations to Distinguish Isomeric Amino Acid–Bile Acid Conjugates and Assess Their Presence and Perturbations in Model Systems

Stewart, A. K., Foley, M. H., Dougherty, M. K., McGill, S. K., Gulati, A. S., Gentry, E. C., … Baker, E. S. (2023, October 5). Analytical Chemistry.

By: A. Stewart n, M. Foley n, M. Dougherty *, S. McGill *, A. Gulati *, E. Gentry *, L. Hagey*, P. Dorrestein * ...

MeSH headings : Humans; Mice; Animals; Bile Acids and Salts; Amino Acids; Isomerism; Mass Spectrometry; Steroids
topics (OpenAlex): Drug Transport and Resistance Mechanisms; Gut microbiota and health; Metabolomics and Mass Spectrometry Studies
TL;DR: This work analyzed 8 core bile acids synthetically conjugated with 22 proteinogenic and nonproteogenic amino acids totaling 176 MCBAs and created an in-house extended bile acid library that was applied to healthy mice dosed with antibiotics and humans having fecal microbiota transplantation (FMT) to assess the MCBA presence and changes in the gut before and after each perturbation. (via Semantic Scholar)
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Source: Web Of Science
Added: October 30, 2023

2021 article

Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization

Foley, M. H., Sarah, O. F., Allen, G., Rivera, A. J., Stewart, A. K., Barrangou, R., & Theriot, C. M. (2021, February 1). Proceedings of the National Academy of Sciences, Vol. 118.

By: M. Foley n, O. Sarah n, G. Allen n, A. Rivera n, A. Stewart n, R. Barrangou n , C. Theriot n

author keywords: Lactobacillus; Acidophilus; gasseri; bile salt hydrolase; bile acid
MeSH headings : Amidohydrolases / genetics; Amidohydrolases / metabolism; Ecosystem; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Genetic Fitness / genetics; Host-Pathogen Interactions / genetics; Humans; Lactobacillus / enzymology; Lactobacillus / genetics; Probiotics / pharmacology; Substrate Specificity / genetics
topics (OpenAlex): Gut microbiota and health; Drug Transport and Resistance Mechanisms; Probiotics and Fermented Foods
TL;DR: It is shown that BA type and BSH substrate preferences affect in vitro and in vivo growth of both species and that BSH enzymatic preferences and the intrinsic chemical features of various BAs determine the toxicity of these molecules during Lactobacillus growth. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 2, 2021

2021 article

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

Fletcher, J. R., Pike, C. M., Parsons, R. J., Rivera, A. J., Foley, M. H., McLaren, M. R., … Theriot, C. M. (2021, January 19). Nature Communications, Vol. 12.

By: J. Fletcher n , C. Pike n, R. Parsons  n, A. Rivera n, M. Foley n, M. McLaren n , S. Montgomery *, C. Theriot n

MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacterial Toxins / genetics; Bacterial Toxins / immunology; Bacterial Toxins / metabolism; Bacteroides / drug effects; Bacteroides / metabolism; Clostridioides difficile / genetics; Clostridioides difficile / immunology; Clostridioides difficile / metabolism; Clostridium Infections / immunology; Clostridium Infections / microbiology; Clostridium Infections / pathology; Disease Models, Animal; Extracellular Matrix / metabolism; Female; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / immunology; Gene Expression Regulation, Bacterial / immunology; Host-Pathogen Interactions / genetics; Host-Pathogen Interactions / immunology; Humans; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Male; Matrix Metalloproteinases / metabolism; Mice; Nutrients / metabolism; Proteolysis; RNA, Bacterial / genetics; RNA, Bacterial / isolation & purification; RNA-Seq; Sigma Factor / genetics; Sigma Factor / immunology; Sigma Factor / metabolism; Transcriptome / immunology
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Gut microbiota and health; Gastrointestinal motility and disorders
TL;DR: Insight is provided into how toxin-induced inflammation alters C. difficile metabolism, host tissue gene expression and gut microbiota, together influencing a beneficial niche for infection. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 20, 2021

2020 article

Simple Analysis of Primary and Secondary Bile Salt Hydrolysis in Mouse and Human Gut Microbiome Samples by Using Fluorogenic Substrates

Sveistyte, A., Gibbins, T., Tyrrell, K. J., Miller, C. J., Foley, M. H., Plymale, A. E., … Brandvold, K. R. (2020, August 5). ChemBioChem.

By: A. Sveistyte*, T. Gibbins*, K. Tyrrell*, C. Miller*, M. Foley n, A. Plymale *, A. Wright *, K. Brandvold *

author keywords: bile; chemical biology; fluorescence; gut microbiome; metabolism
MeSH headings : Animals; Bile Acids and Salts / chemical synthesis; Bile Acids and Salts / chemistry; Bile Acids and Salts / metabolism; Fluorescent Dyes / chemical synthesis; Fluorescent Dyes / chemistry; Fluorescent Dyes / metabolism; Gastrointestinal Microbiome; Humans; Hydrolysis; Mice; Molecular Conformation
topics (OpenAlex): Drug Transport and Resistance Mechanisms; Gut microbiota and health; Pharmacological Effects and Toxicity Studies
TL;DR: The data demonstrate that most gut microbiomes have the highest capacity for hydrolysis of host‐produced primary bile salts, but some microbially modified secondary bile salt also display significant turnover. (via Semantic Scholar)
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Source: Web Of Science
Added: October 26, 2020

2019 article

Bile salt hydrolases: Gatekeepers of bile acid metabolism and host-microbiome crosstalk in the gastrointestinal tract

Foley, M. H., Sarah, O. F., Barrangou, R., & Theriot, C. M. (2019, March 7). (L. J. Knoll, Ed.). PLoS Pathogens, Vol. 15.

By: M. Foley n, O. Sarah n, R. Barrangou n  & C. Theriot n

Ed(s): L. Knoll

MeSH headings : Amidohydrolases / metabolism; Amidohydrolases / physiology; Bile Acids and Salts / metabolism; Gastrointestinal Microbiome / physiology; Gastrointestinal Tract; Host Microbial Interactions / physiology; Humans
topics (OpenAlex): Drug Transport and Resistance Mechanisms; Pediatric Hepatobiliary Diseases and Treatments; Antibiotic Resistance in Bacteria
TL;DR: Bile acids serve as substrates for bile acid receptors (BARs) found throughout the body that control critical regulatory and metabolic processes and therefore represent an important class of bioactive molecules, and there remain gaps in knowledge about the bacterial enzymes driving their composition and modification. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 15, 2019

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