Michael Gamcsik

Works (21)

Updated: July 25th, 2023 05:04

2023 article

Assessing MTT and sulforhodamine B cell proliferation assays under multiple oxygen environments

Yao, M., Walker, G., & Gamcsik, M. P. (2023, July 5). CYTOTECHNOLOGY.

By: M. Yao n, G. Walker n & M. Gamcsik n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: MTT assay; SRB; Oxygen partial pressure; Hypoxia; Proliferation; Cancer
Source: Web Of Science
Added: July 24, 2023

2022 journal article

Direct Detection of Glutathione Biosynthesis, Conjugation, Depletion and Recovery in Intact Hepatoma Cells

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(9).

By: R. Jeffries n, S. Gomez n, J. Macdonald n & M. Gamcsik n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: glutathione; antioxidant; nuclear magnetic resonance spectroscopy; noninvasive; alkylating agent; metabolism
MeSH headings : Animals; Bioreactors; Bridged Bicyclo Compounds; Carcinoma, Hepatocellular; Glutathione / metabolism; Humans; Liver Neoplasms; Rats
Source: Web Of Science
Added: June 6, 2022

2022 article

Highlighting Functional Mass Spectrometry Imaging Methods in Bioanalysis

Mellinger, A. L., Muddiman, D. C., & Gamcsik, M. P. (2022, June 27). JOURNAL OF PROTEOME RESEARCH, Vol. 6.

By: A. Mellinger n, D. Muddiman nโ€‰ & M. Gamcsik n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: mass spectrometry imaging; kinetics; rate; isotope; metabolism; dynamics
MeSH headings : Magnetic Resonance Imaging; Mass Spectrometry / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 journal article

Mapping glycine uptake and its metabolic conversion to glutathione in mouse mammary tumors using functional mass spectrometry imaging

FREE RADICAL BIOLOGY AND MEDICINE, 193, 677โ€“684.

By: A. Mellinger n, R. Kibbe n, Z. Rabbani n, D. Meritet n, D. Muddiman nโ€‰ & M. Gamcsik n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Mice; Animals; Glycine; Biological Transport; Glutathione; Mammary Neoplasms, Animal; Mass Spectrometry
Sources: Web Of Science, ORCID
Added: January 23, 2023

2022 journal article

Multiple Infusion Start Time Mass Spectrometry Imaging of Dynamic SIL-Glutathione Biosynthesis Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization

JOURNAL OF PROTEOME RESEARCH, 21(3), 747โ€“757.

By: A. Mellinger n, K. Garrard n, S. Khodjaniyazova n, Z. Rabbani n, M. Gamcsik n & D. Muddiman nโ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: IR-MALDESI; mass spectrometry imaging; stable isotope labeling; glutathione; kinetic metabolism
MeSH headings : Animals; Glutathione; Glycine; Lasers; Mice; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
Sources: Web Of Science, ORCID
Added: May 2, 2022

2021 journal article

A multiwell plate-based system for toxicity screening under multiple static or cycling oxygen environments

SCIENTIFIC REPORTS, 11(1).

By: M. Yaoโ€‰ n, G. Walker* & M. Gamcsik n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Cell Culture Techniques / instrumentation; Cell Culture Techniques / methods; Cell Hypoxia / drug effects; Cell Hypoxia / physiology; Cell Line, Tumor / metabolism; Doxorubicin / pharmacology; High-Throughput Screening Assays / methods; Humans; Neoplasms / metabolism; Oxygen / metabolism; Pancreatic Neoplasms / metabolism; Tirapazamine / pharmacology; Toxicity Tests / methods; Triazines / pharmacology; Tumor Microenvironment / physiology
Source: Web Of Science
Added: March 22, 2021

2019 journal article

Flow-Encoded Oxygen Control to Track the Time-Dependence of Molecular Changes Induced by Static or Cycling Hypoxia

ANALYTICAL CHEMISTRY, 91(23), 15032โ€“15039.

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aldehyde Dehydrogenase / metabolism; Caco-2 Cells; Cell Hypoxia; Cell Line, Tumor; Glucose / pharmacokinetics; Humans; Hypoxia-Inducible Factor 1, alpha Subunit / drug effects; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Oxygen / metabolism; Oxygen / pharmacology; Pancreatic Neoplasms / pathology; Time Factors
Source: Web Of Science
Added: December 30, 2019

2018 journal article

Mixing and delivery of multiple controlled oxygen environments to a single multiwell culture plate

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 315(5), C766โ€“C775.

By: M. Yao n, T. Sattler n, Z. Rabbani n, T. Pulliamโ€‰ n, G. Walker n & M. Gamcsik n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: cell culture; cycling hypoxia; finite element analysis; oxygen diffusion; permeability
MeSH headings : Caco-2 Cells; Cell Culture Techniques / instrumentation; Cell Hypoxia / genetics; Cell Proliferation / genetics; Humans; Hypoxia-Inducible Factor 1, alpha Subunit / chemistry; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; MCF-7 Cells; Oxygen / chemistry; Oxygen / metabolism
Source: Web Of Science
Added: December 10, 2018

2015 journal article

Biocompatibility of Tygonยฎ tubing in microfluidic cell culture

Biomedical Microdevices, 17(1).

By: X. Jiangโ€‰ n, R. Jeffries n, M. Acosta n, A. Tikunov n, J. Macdonald n, G. Walker n, M. Gamcsik n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Biomaterial; Cancer cell; Biocompatibility; Toxicity; Polyvinylchloride; Spectroscopy
MeSH headings : Cell Culture Techniques / instrumentation; Cell Culture Techniques / methods; Cell Line, Tumor; Female; Humans; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods
Source: Crossref
Added: August 28, 2020

2014 journal article

A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia

Biomicrofluidics, 8(5), 054117.

By: M. Acosta n, X. Jiang n, P. Huang*, K. Cutler*, C. Grant nโ€‰, G. Walker n, M. Gamcsik*

co-author countries: Taiwan, Province of China ๐Ÿ‡น๐Ÿ‡ผ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Sources: Crossref, Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Noninvasive In Vivo Magnetic Resonance Measures of Glutathione Synthesis in Human and Rat Liver as an Oxidative Stress Biomarker

HEPATOLOGY, 59(6), 2321โ€“2330.

By: J. Skamarauskas*, F. Oakleyโ€‰*, F. Smith*, C. Bawnโ€‰*, M. Dunn*, D. Vidler*, M. Clemence*, P. Blain* ...

co-author countries: United Kingdom of Great Britain and Northern Ireland ๐Ÿ‡ฌ๐Ÿ‡ง United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Adult; Animals; Biomarkers / metabolism; Carbon Isotopes; Glutathione / biosynthesis; Glycine; Humans; Liver / metabolism; Magnetic Resonance Imaging; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Translational Research, Biomedical
Source: Web Of Science
Added: August 6, 2018

2012 journal article

13C magnetic resonance spectroscopy detection of changes in serine isotopomers reflects changes in mitochondrial redox status

MAGNETIC RESONANCE IN MEDICINE, 68(3), 671โ€“679.

By: C. Johnson*, A. Tikunov*, H. Lee*, J. Wolak*, P. Pediaditakis*, D. Romney*, E. Holmuhamedovโ€‰*, M. Gamcsik n, J. Macdonald*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: serine 13C isotopomers; 13C NMR spectroscopy; mitochondrial redox; 2-13C-glycine; hepatocytes; confocal microscopy
MeSH headings : Animals; Carbon Isotopes; Cells, Cultured; Hepatocytes / metabolism; Hepatocytes / ultrastructure; Male; Mitochondria, Liver / metabolism; NAD / analysis; Oxidation-Reduction; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Serine / analysis
Source: Web Of Science
Added: August 6, 2018

2012 journal article

In vivo MR studies of glycine and glutathione metabolism in a rat mammary tumor

NMR IN BIOMEDICINE, 25(2), 271โ€“278.

By: P. Thelwallโ€‰*, N. Simpson*, Z. Rabbani*, M. Clark*, R. Pourdeyhimi n, J. Macdonald n, S. Blackband*, M. Gamcsik n

co-author countries: United Kingdom of Great Britain and Northern Ireland ๐Ÿ‡ฌ๐Ÿ‡ง United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: glutathione; MR; serine; metabolism; trans-sulfuration
MeSH headings : Animals; Carbon Isotopes; Female; Glutathione / metabolism; Glycine / metabolism; Magnetic Resonance Spectroscopy / methods; Mammary Neoplasms, Animal / metabolism; Mammary Neoplasms, Animal / pathology; Mass Spectrometry; Neoplasm Transplantation; Rats; Rats, Inbred F344; Subcutaneous Tissue / pathology
Source: Web Of Science
Added: August 6, 2018

2011 journal article

In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis

PLoS Pathogens, 7(7).

By: N. Grahl, S. Puttikamonkul, J. Macdonald, M. Gamcsik, L. Ngo, T. Hohl, R. Cramer

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Synthesis of 13C-labeled derivatives of cysteine for magnetic resonance imaging studies of drug uptake and conversion to glutathione in rat brain

Journal of Labelled Compounds and Radiopharmaceuticals, 54(9), 607โ€“612.

By: P. Amoyaw*, J. Springer*, M. Gamcsik n, R. Mutesi*, M. D'Alessandro*, C. Dempsey*, S. Ludeman*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: C-13-labeling; synthesis; N-acetylcysteine; 2-oxothiazolidine-4-carboxylic acid; OTZ; ethyl glutamylcysteinate
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

Non-invasive Monitoring of L-2-Oxothiazolidine-4-Carboxylate Metabolism in the Rat Brain by In vivo 13C Magnetic Resonance Spectroscopy

Neurochemical Research, 36(3), 443โ€“451.

By: M. Gamcsik n, M. Daniel Clark*, S. Ludeman*, J. Springer*, M. Dโ€™Alessandro*, N. Simpson*, R. Pourdeyhimi n, C. Bryce Johnson n ...

co-author countries: United Kingdom of Great Britain and Northern Ireland ๐Ÿ‡ฌ๐Ÿ‡ง United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Magnetic resonance; Metabolism; Cysteine; Glutathione; Taurine
MeSH headings : Animals; Brain / metabolism; Female; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular / methods; Oxidative Stress; Pyrrolidonecarboxylic Acid / metabolism; Rats; Rats, Inbred F344; Thiazolidines / metabolism
Sources: Crossref, ORCID
Added: August 27, 2020

2005 journal article

Intrastrand base-stacking buttresses widening of major groove in interstrand cross-linked B-DNA

Bioorganic & Medicinal Chemistry, 13(14), 4580โ€“4587.

By: M. da Silvaโ€‰*, R. Bierbryer*, C. Wildsโ€‰*, A. Noronha*, O. Colvin*, P. Millerโ€‰*, M. Gamcsik*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: DNA interstrand crosslinks; DNA repair; solution NMR structure
MeSH headings : DNA / chemistry; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation
Source: Crossref
Added: August 28, 2020

2005 journal article

Structure, Flexibility, and Repair of Two Different Orientations of the Same Alkyl Interstrand DNA Cross-Linkโ€ 

Biochemistry, 44(18), 6764โ€“6775.

By: D. Noll*, M. Webba da Silvaโ€‰*, A. Noronha*, C. Wildsโ€‰*, O. Colvin*, M. Gamcsik*, P. Millerโ€‰*

co-author countries: Canada ๐Ÿ‡จ๐Ÿ‡ฆ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Alkylating Agents / chemistry; CpG Islands; Cross-Linking Reagents / chemistry; DNA Repair; DNA, Circular / chemistry; Intercalating Agents / chemistry; Microscopy, Atomic Force; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Nucleic Acid Heteroduplexes / chemical synthesis; Plasmids; Thermodynamics
Source: Crossref
Added: August 28, 2020

2004 journal article

Accommodation of Mispair Aligned N3T-Ethyl-N3T DNA Interstrand Cross Linkโ€ 

Biochemistry, 43(39), 12549โ€“12554.

By: M. Webba da Silvaโ€‰*, C. Wildsโ€‰*, A. Noronha*, O. Colvin*, P. Millerโ€‰* & M. Gamcsik*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Base Pair Mismatch; Base Sequence; Cross-Linking Reagents / chemistry; Crystallography, X-Ray; DNA / chemical synthesis; DNA / genetics; DNA Damage; DNA Repair; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Heteroduplexes / chemistry; Nucleic Acid Heteroduplexes / genetics; Oligonucleotides / chemistry; Oligonucleotides / genetics; Thermodynamics; Thymine / chemistry
Source: Crossref
Added: January 21, 2021

2004 journal article

Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine

Cancer Chemotherapy and Pharmacology, 55(4), 333โ€“342.

By: M. Fishelโ€‰*, M. Gamcsik*, S. Delaney*, E. Zuhowski*, V. Maher*, T. Karrison*, R. Moschel*, M. Egorin*, M. Dolan*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: cisplatin; modulation; chemotherapy
MeSH headings : Antineoplastic Agents / pharmacology; Cell Line; Cell Survival / drug effects; Cisplatin / pharmacology; DNA Damage; DNA Repair / drug effects; Drug Synergism; Glutathione / metabolism; Guanine / analogs & derivatives; Guanine / pharmacology; Humans; Platinum / metabolism; Tumor Cells, Cultured
Source: Crossref
Added: January 21, 2021

1996 journal article

A versatile oxygenator and perfusion system for magnetic resonance studies

Biotechnology and Bioengineering, 49(3), 348โ€“354.

By: M. Gamcsik*, J. Forder, K. Millis & K. McGovern

author keywords: oxygenator; NMR spectroscopy; organ perfusion; mammalian cell culture
Source: Crossref
Added: January 28, 2021

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