Works (8)
Updated: August 16th, 2023 21:16
2022 journal article
A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes
JOURNAL OF CONTROLLED RELEASE, 343, 518–527.
author keywords: PBPK model; Polyethylene glycol; PEGylated liposomes; Accelerated blood clearance; Anti-PEG antibodies
MeSH headings : Animals; Antibodies; Kinetics; Liposomes; Mice; Polyethylene Glycols / pharmacokinetics; Positron Emission Tomography Computed Tomography; Tissue Distribution
topics (OpenAlex): Monoclonal and Polyclonal Antibodies Research; Protein purification and stability; Nanoparticle-Based Drug Delivery
TL;DR:
A physiologically based pharmacokinetic (PBPK) model designed to resolve APA's impact on both early- and late-phase pharmacokinetics and biodistribution of intravenously administered PEGylated drugs is developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 23, 2022
2021 journal article
Experimental Data and PBPK Modeling Quantify Antibody Interference in PEGylated Drug Carrier Delivery
BULLETIN OF MATHEMATICAL BIOLOGY, 83(12).
author keywords: PBPK model; Latin hypercube sampling; Parameter optimization; Anti-PEG antibodies; PEGylated liposomes
MeSH headings : Animals; Drug Carriers; Mathematical Concepts; Mice; Models, Biological; Polyethylene Glycols / pharmacokinetics; Positron Emission Tomography Computed Tomography; Tissue Distribution
topics (OpenAlex): thermodynamics and calorimetric analyses; Protein purification and stability; Drug Transport and Resistance Mechanisms
TL;DR:
Near-continuous experimental measurements of PL concentration during the first hour post-injection from the liver, spleen, kidney, muscle, lung, and blood plasma, are used as truth sets with LHS to infer optimal parameter ranges for the full PBPK model.
(via Semantic Scholar)
open access via link.springer.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 23, 2021
2020 journal article
LPS-binding IgG arrests actively motile Salmonella Typhimurium in gastrointestinal mucus
MUCOSAL IMMUNOLOGY, 13(5), 814–823.
MeSH headings : Animals; Antibodies, Bacterial / immunology; Disease Models, Animal; Immunoglobulin Fab Fragments / immunology; Immunoglobulin Fc Fragments / immunology; Immunoglobulin G / immunology; Intestinal Mucosa; Lipopolysaccharides / immunology; Mice; Mucus / immunology; Mucus / microbiology; Polysaccharides / immunology; Protein Binding / immunology; Salmonella Infections / immunology; Salmonella Infections / microbiology; Salmonella typhimurium / immunology
topics (OpenAlex): Escherichia coli research studies; Glycosylation and Glycoproteins Research; Bacteriophages and microbial interactions
TL;DR:
The addition of anti-lipopolysaccharide IgG to GI mucus markedly reduced the progressive motility of Salmonella by lowering the swim speed and retaining individual bacteria in an undirected motion state, implicate IgG-mucin crosslinking as a broadly conserved function that reduces mucous penetration of both bacterial and viral pathogens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: March 23, 2020
2020 journal article
Modeling the Mechanisms by Which Coexisting Biomolecular RNA-Protein Condensates Form
BULLETIN OF MATHEMATICAL BIOLOGY, 82(12).
author keywords: Liquid– liquid phase separation; Flory– Huggins; RNA– protein dynamics; Phase field model
MeSH headings : Biophysical Phenomena; Kinetics; Mathematical Concepts; Models, Biological; Proteins / metabolism; RNA / metabolism
topics (OpenAlex): RNA Research and Splicing; RNA modifications and cancer; RNA and protein synthesis mechanisms
TL;DR:
This work presents a mathematical model to examine molecular mechanisms that yield phase-separated droplets composed of different RNA–protein complexes using a Cahn–Hilliard diffuse interface model with a Flory–Huggins free energy scheme to explore how multiple protein–RNA complexes can establish a heterogeneous droplet field.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 21, 2020
2020 journal article
Spatial heterogeneity of the cytosol revealed by machine learning-based 3D particle tracking
MOLECULAR BIOLOGY OF THE CELL, 31(14), 1498–1511.
MeSH headings : Cytoplasm / metabolism; Cytoplasm / physiology; Cytosol / metabolism; Cytosol / physiology; Eremothecium / metabolism; Image Processing, Computer-Assisted / methods; Machine Learning; Nanoparticles; Orientation, Spatial / physiology; Single Molecule Imaging / methods
topics (OpenAlex): Heat shock proteins research; RNA Research and Splicing; Genomics and Chromatin Dynamics
TL;DR:
The physical properties of the cytosol vary substantially in time and space and can be a source of heterogeneity within individual cells and across populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 3, 2020
2019 journal article
Modeling Barrier Properties of Intestinal Mucus Reinforced with IgG and Secretory IgA against Motile Bacteria
ACS INFECTIOUS DISEASES, 5(9), 1570–1580.
author keywords: mucin; immunoglobulins; mucosal immunity; pathogen
MeSH headings : Agglutination; Animals; Bacteria / immunology; Bacteria / pathogenicity; Binding Sites; Humans; Immunoglobulin A, Secretory / chemistry; Immunoglobulin A, Secretory / metabolism; Immunoglobulin G / chemistry; Immunoglobulin G / metabolism; Intestinal Mucosa / immunology; Models, Theoretical; Mucins / chemistry; Mucins / immunology; Protein Binding
topics (OpenAlex): Immunodeficiency and Autoimmune Disorders; Probiotics and Fermented Foods; Immune Cell Function and Interaction
TL;DR:
A mathematical model is developed that improves the mechanistic understanding of Ab-enhanced barrier properties of mucus and highlights the ability for muco-trapping Ab to protect against motile pathogens at mucosal surfaces.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 7, 2019
2019 journal article
Partial demixing of RNA-protein complexes leads to intradroplet patterning in phase-separated biological condensates
PHYSICAL REVIEW E, 99(1).
MeSH headings : Kinetics; Models, Biological; RNA / metabolism; RNA-Binding Proteins / metabolism
topics (OpenAlex): RNA Research and Splicing; RNA and protein synthesis mechanisms; Advanced Mathematical Modeling in Engineering
TL;DR:
This study illustrates that spatiotemporal heterogeneity can emerge within phase-separated biological condensates with simple binding reactions and competition and demonstrates that intradroplet patterning may influence droplet composition and, subsequently, cellular organization on a larger scale.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 20, 2020
2014 journal article
Transient Antibody-Mucin Interactions Produce a Dynamic Molecular Shield against Viral Invasion
BIOPHYSICAL JOURNAL, 106(9), 2028–2036.
MeSH headings : Antibodies, Neutralizing / immunology; Antibodies, Neutralizing / metabolism; Antibodies, Viral / metabolism; Antibody Specificity; Cervix Uteri / virology; Female; HIV-1 / physiology; Humans; Immunoglobulin G / immunology; Kinetics; Mucins / metabolism; Mucus / virology; Protein Binding; Vagina / virology
topics (OpenAlex): Reproductive tract infections research; HIV Research and Treatment; Reproductive System and Pregnancy
TL;DR:
The model developed here is adaptable to other pathogens, mucosal barriers, and geometries, as well as kinetic and diffusional effects, providing a tool for hypothesis testing and producing quantitative insights into the dynamics of immune-mediated protection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018