Malgorzata Goralska

Works (18)

Updated: July 15th, 2023 21:16
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2017 journal article

Vitreous Humor Changes Expression of Iron-Handling Proteins in Lens Epithelial Cells

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58(2).

By: M. Goralska n, L. Fleisher n & M. McGahan n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: iron; oxidative damage; ferritin; transferrin receptor; vitreous humor
MeSH headings : Animals; Aquaporins / metabolism; Blotting, Western; Cells, Cultured; Disease Models, Animal; Dogs; Epithelial Cells / metabolism; Eye Proteins / metabolism; Ferritins / metabolism; Immunohistochemistry; Lens, Crystalline / metabolism; Receptors, Transferrin / metabolism; Vitreous Body / physiology
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Hypoxia induced changes in expression of proteins involved in iron uptake and storage in cultured lens epithelial cells

EXPERIMENTAL EYE RESEARCH, 125, 135–141.

By: M. Goralska n, L. Fleisher n & M. McGahan n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: lens; iron; iron proteins; hypoxia
MeSH headings : Animals; Cell Hypoxia / physiology; Cells, Cultured; Dogs; Epithelial Cells / metabolism; Ferritins / metabolism; Gene Expression Regulation; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Oxidative Stress / physiology; RNA, Messenger / metabolism; Real-Time Polymerase Chain Reaction; Receptors, Transferrin / metabolism; Transferrin / metabolism
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Source-Dependent Intracellular Distribution of Iron in Lens Epithelial Cells Cultured Under Normoxic and Hypoxic Conditions

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(12), 7666–7673.

By: M. Goralska n, S. Nagar*, L. Fleisher*, P. Mzyk* & M. McGahan

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: iron trafficking; transferrin; NTBI; lens epithelial cells; hypoxia
MeSH headings : Animals; Biological Transport; Cell Nucleus / metabolism; Cell Proliferation; Cell Survival; Cells, Cultured; Chlorides / metabolism; Dogs; Epithelial Cells / metabolism; Ferric Compounds / metabolism; Hypoxia / metabolism; Intracellular Fluid / metabolism; Iron Radioisotopes / metabolism; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Mitochondria / metabolism; Transferrin / metabolism
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Ceruloplasmin alters intracellular iron regulated proteins and pathways: Ferritin, transferrin receptor, glutamate and hypoxia-inducible factor-1Ξ±

Experimental Eye Research, 97(1), 90–97.

By: J. Harned n, J. Ferrell n, S. Nagar n, M. Goralska n, L. Fleisher n & M. McGahan n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: ceruloplasmin; iron; lens epithelial cells; retinal pigmented epithelial cells glutamate; hypoxia-inducible factor; transferrin receptor; ferritin
MeSH headings : Animals; Cells, Cultured; Ceruloplasmin / metabolism; Ceruloplasmin / pharmacology; Dogs; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / metabolism; Fluorescent Antibody Technique, Indirect; Glutamic Acid / metabolism; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Iron Chelating Agents / pharmacology; Lens, Crystalline / cytology; Oxalates / pharmacology; Receptors, Transferrin / metabolism; Retinal Pigment Epithelium / drug effects; Retinal Pigment Epithelium / metabolism
Sources: Web Of Science, Crossref
Added: August 6, 2018

2010 journal article

Altered Ferritin Subunit Composition: Change in Iron Metabolism in Lens Epithelial Cells and Downstream Effects on Glutathione Levels and VEGF Secretion

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 51(9), 4437–4446.

By: J. Harned n, J. Ferrell n, M. Lall n, L. Fleisher n, S. Nagar n, M. Goralska n, M. McGahan n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Apoferritins / genetics; Apoferritins / metabolism; Cell Nucleus / metabolism; Cells, Cultured; Culture Media, Conditioned / pharmacology; Cystine / pharmacokinetics; Dogs; Epithelial Cells / cytology; Epithelial Cells / metabolism; Glutathione / metabolism; Homeostasis / physiology; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Iron / metabolism; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Oxidative Stress / physiology; Protein Subunits / genetics; Protein Subunits / metabolism; RNA, Small Interfering; Transfection; Vascular Endothelial Growth Factor A / metabolism
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Changes in Ferritin H- and L-Chains in Canine Lenses with Age-Related Nuclear Cataract

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 50(1), 305–310.

By: M. Goralska n, S. Nagar n, C. Colitz n, L. Fleisher n & M. McGahan n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Aging; Animals; Apoferritins / metabolism; Cataract / metabolism; Cataract / veterinary; Dog Diseases / metabolism; Dogs; Electrophoresis, Polyacrylamide Gel / veterinary; Enzyme-Linked Immunosorbent Assay / veterinary; Fluorescent Antibody Technique, Indirect / veterinary; Lens, Crystalline / metabolism; Microscopy, Fluorescence / veterinary
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Distribution of ferritin chains in canine lenses with and without age-related nuclear cataracts

Molecular Vision, 15(256-59), 2404–2410.

By: M. Goralska, S. Nagar, L. Fleisher & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Iron metabolism in the eye: A review

Experimental Eye Research, 88(2), 204–215.

By: M. Goralska n, J. Ferrell n, J. Harned n, M. Lall n, S. Nagar n, L. Fleisher n, M. McGahan n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: iron; ferritin; transferrin; lens; retinal pigmented epithelium; retina
MeSH headings : Animals; Eye / metabolism; Eye Diseases / metabolism; Homeostasis; Humans; Iron / metabolism; Oxidative Stress; Signal Transduction / physiology
Sources: Web Of Science, Crossref
Added: August 6, 2018

2007 journal article

Ferritin H- and L-chains in fiber cell canine and human lenses of different ages

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 48(9), 3968–3975.

By: M. Goralska n, L. Fleisher n & M. McGahan n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Adolescent; Adult; Aged; Aging / physiology; Animals; Apoferritins / metabolism; Blotting, Western; Dogs; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Ferritins / metabolism; Humans; Iron Radioisotopes / metabolism; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Middle Aged
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Differential degradation of ferritin H- and L-chains: Accumulation of L-chain-rich ferritin in lens epithelial cells

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 46(10), 3521–3529.

By: M. Goralska n, S. Nagar n, L. Fleisher n & M. McGahan n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Aging / physiology; Animals; Apoferritins; Cells, Cultured; Cysteine Proteinase Inhibitors / pharmacology; Dogs; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / metabolism; Iron / metabolism; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Lysosomes / metabolism; Methionine / metabolism; Plasmids; Transfection
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Iron alters glutamate secretion by regulating cytosolic aconitase activity

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 288(5), C1117–C1124.

By: M. McGahan, J. Harned*, M. Mukunnemkeril, M. Goralska*, L. Fleisher* & J. Ferrell*

author keywords: retinal pigment epithelial cells; lens epithelial cells
MeSH headings : Aconitate Hydratase / antagonists & inhibitors; Aconitate Hydratase / metabolism; Animals; Cells, Cultured; Citric Acid / metabolism; Cytosol / metabolism; Dogs; Enzyme Activation / drug effects; Glutamates / metabolism; Iron / metabolism; Isocitrates / metabolism; Membrane Transport Proteins / metabolism; Oxalates / pharmacology; Pigment Epithelium of Eye / drug effects; Pigment Epithelium of Eye / enzymology; Riluzole / pharmacology; Vesicular Glutamate Transport Protein 1
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Alpha lipoic acid changes iron uptake and storage in lens epithelial cells

EXPERIMENTAL EYE RESEARCH, 76(2), 241–248.

By: M. Goralska n, R. Dackor n, B. Holley n & M. McGahan n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: alpha lipoic acid (LA); Fe; ferritin; oxidative damage; calcein; labile Fe pool
MeSH headings : Animals; Antioxidants / pharmacology; Ascorbic Acid / pharmacology; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / biosynthesis; Ferritins / metabolism; Hydrogen Peroxide / antagonists & inhibitors; Hydrogen Peroxide / pharmacology; Iron / pharmacokinetics; Lens Capsule, Crystalline / cytology; Lens Capsule, Crystalline / drug effects; Lens Capsule, Crystalline / metabolism; Oxidative Stress / drug effects; Thioctic Acid / pharmacology
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Identification of a mechanism by which lens epithelial cells limit accumulation of overexpressed ferritin H-chain

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(44), 42920–42926.

By: M. Goralska n, B. Holley n & M. McGahan n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Apoferritins; Blotting, Western; Cataract / metabolism; Cytosol / metabolism; DNA, Complementary / metabolism; Dogs; Electrophoresis, Polyacrylamide Gel; Epithelial Cells / metabolism; Eye Diseases, Hereditary / metabolism; Ferritins / biosynthesis; Ferritins / chemistry; Ferritins / metabolism; Humans; Iron Metabolism Disorders; Lens, Crystalline / metabolism; Mutation; Peptides / chemistry; Plasmids / metabolism; Precipitin Tests; RNA, Messenger / metabolism; Recombinant Proteins / metabolism; Time Factors; Transfection
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Overexpression of H- and L-ferritin subunits in lens epithelial cells: Fe metabolism and cellular response to UVB irradiation

Investigative Ophthalmology and Visual Science, 42(8), 1721–1727.

By: M. Goralska, B. Holley & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

The effects of Tempol on ferritin synthesis and Fe metabolism in lens epithelial cells

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1497(1), 51–60.

By: M. Goralska n, B. Holley n & M. McGahan n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: ferritin; Fe metabolism; lens; cataract; lens epithelial cell; tempol; oxidative damage; peroxide; free radical
MeSH headings : Animals; Antioxidants / pharmacology; Cyclic N-Oxides / pharmacology; Dogs; Dose-Response Relationship, Drug; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Female; Ferritins / biosynthesis; Ferritins / drug effects; Iron / metabolism; Lens, Crystalline / cytology; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Male; Spin Labels; Time Factors; tert-Butylhydroperoxide / pharmacology
Source: Web Of Science
Added: August 6, 2018

1998 journal article

The effect of ascorbic acid and ferric ammonium citrate on iron uptake and storage in lens epithelial cells

EXPERIMENTAL EYE RESEARCH, 66(6), 687–697.

By: M. Goralska n, J. Harned n, L. Fleisher n & M. McGahan n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: ascorbic acid; ferritin; lens; iron; ferric ammonium citrate; transferrin
MeSH headings : Animals; Apoferritins / biosynthesis; Ascorbic Acid / pharmacology; Cells, Cultured; Chlorides; Dogs; Epithelial Cells / metabolism; Ferric Compounds / metabolism; Ferric Compounds / pharmacology; Homeostasis; Humans; Infant, Newborn; Iron Radioisotopes / metabolism; Lens, Crystalline / metabolism; Quaternary Ammonium Compounds / pharmacology; Transferrin / metabolism
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Mechanisms by which ascorbic acid increases ferritin levels in cultured lens epithelial cells

EXPERIMENTAL EYE RESEARCH, 64(3), 413–421.

By: M. Goralska n, J. Harned n, A. Grimes n, L. Fleisher n & M. McGahan n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: ascorbic acid; ferritin; lens; cataract
MeSH headings : Animals; Ascorbic Acid / metabolism; Ascorbic Acid / pharmacology; Base Sequence; Blotting, Northern; Cells, Cultured; DNA / metabolism; Deferoxamine / pharmacology; Dithiothreitol / pharmacology; Dogs; Epithelium / drug effects; Epithelium / metabolism; Ferric Compounds / metabolism; Ferritins / biosynthesis; Ferritins / drug effects; Ferritins / genetics; Hydrogen Peroxide / pharmacology; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Molecular Sequence Data; Oxidation-Reduction; Protein Biosynthesis; Protein Synthesis Inhibitors / pharmacology; RNA, Messenger / drug effects; RNA, Messenger / metabolism
Source: Web Of Science
Added: August 6, 2018

1995 journal article

TRANSFERRIN SECRETION BY LENS EPITHELIAL-CELLS IN CULTURE

EXPERIMENTAL EYE RESEARCH, 60(6), 667–673.

By: M. Mcgahan n, J. Harned n, M. Goralska n, B. Sherry n & L. Fleisher n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: TRANSFERRIN; LENS; ANTIOXIDANTS; GROWTH FACTORS; AQUEOUS HUMOR
MeSH headings : Animals; Aqueous Humor / chemistry; Blotting, Northern; Cells, Cultured; Ciliary Body / metabolism; Dogs; Epithelium / metabolism; Lens, Crystalline / metabolism; Rabbits; Secretory Rate; Time Factors; Transferrin / metabolism; Vitreous Body / chemistry
Source: Web Of Science
Added: August 6, 2018