Works (476)

Updated: April 4th, 2024 11:30

2024 article

The effects of food on the pharmacokinetics of mycophenolate mofetil in healthy horses

Bello, K., Lorch, G., Papich, M. G., Kim, K., Toribio, R. E., Yan, L., … Phelps, M. A. (2024, February 9). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 2.

By: K. Bello*, G. Lorch*, M. Papich n, K. Kim*, R. Toribio*, L. Yan*, Z. Xie*, K. Hill*, M. Phelps*

author keywords: equine; fed vs. fasted; immune-mediated; mycophenolate mofetil; pharmacokinetics
TL;DR: Evidence of enterohepatic recirculation was seen only in the fasted state; this did not yield clinical differences in horses administered a single-dose MMF administration but may be significant in horses receiving long-term MMF treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 19, 2024

2023 journal article

Antimicrobial agents in small animal dermatology for treating staphylococcal infections

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 261, S130–S139.

By: M. Papich n

TL;DR: Concerns are discussed that veterinarians may have to rely on antibiotics that were previously used uncommonly for skin infections, such as chloramphenicol, aminoglycosides, tetracyclines, and human-label antibiotics such as rifampin and linezolid. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 11, 2023

2023 article

Effects of storage up to 1 year on the in vitro antimicrobial activity of preformulated antibiotic-impregnated calcium sulfate beads

Hartman, E. A., Hernandez, D. P., Hendrix, G. K., Risselada, M., Weng, H.-Y., Papich, M. G., & Kim, S. Y. (2023, August 13). VETERINARY SURGERY, Vol. 8.

By: E. Hartman*, D. Hernandez*, G. Hendrix*, M. Risselada*, H. Weng*, M. Papich n, S. Kim*

TL;DR: Light protected storage at room temperature for up to 12 months did not impair the in vitro activity of antibiotic-impregnated CaSO4 beads, as demonstrated through ZOIs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 28, 2023

2023 journal article

Pharmacokinetics of a FDA-labeled dose of diclazuril administered orally once weekly to adult horses

JOURNAL OF EQUINE VETERINARY SCIENCE, 120.

By: N. Pusterla*, W. Vaala*, F. Bain*, D. Chappell*, B. Craig*, C. Schneider*, D. Barnett*, E. Gaughan*, M. Papich n

author keywords: Sarcocystis neurona; diclazuril; pharmacokinetic; prevention; horses
MeSH headings : Horses; Animals; Coccidiostats / pharmacology; Coccidiostats / therapeutic use; Seroepidemiologic Studies; Sarcocystis; Nitriles / pharmacology; Nitriles / therapeutic use
TL;DR: The oral administration of an FDA-labeled dose of diclazuril to healthy horses once a week was able to produce steady-state plasma drug concentrations known to inhibit S. neurona in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 23, 2023

2023 article

Pharmacokinetics of pimobendan after oral administration to dogs with myxomatous mitral valve disease

McManamey, A. K., DeFrancesco, T. C., Meurs, K. M., & Papich, M. G. (2023, September 30). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 9.

By: A. McManamey*, T. DeFrancesco n, K. Meurs n & M. Papich n

author keywords: canine; heart failure; valvular heart disease; Vetmedin
TL;DR: The pharmacokinetic parameters were highly variable among this group of dogs with MMVD, and the variability was not associated with the dog's age, body weight or condition score, stage of heart disease, dose, serum creatinine, or alkaline phosphatase. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 1, 2023

2023 article

Population pharmacokinetic analysis of enrofloxacin and its active metabolite ciprofloxacin after intravenous injection to cats with reduced kidney function

Foster, J. D., Abouraya, M., Papich, M. G., & Muma, N. A. (2023, September 20). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 9.

By: J. Foster, M. Abouraya*, M. Papich n & N. Muma*

author keywords: drug prescribing; feline; fluroquinolone; renal failure
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 10, 2023

2023 journal article

Population pharmacokinetics of single dose oral pimobendan in the ferret (Mustela putorius furo)

JOURNAL OF EXOTIC PET MEDICINE, 48, 1–5.

By: M. Cabot n, M. Papich n, T. Harrison n, A. Thomson n, T. Defrancesco n & S. Ozawa n

author keywords: Ferret; Pimobendan; Pharmacokinetic; Mustela putorius furo; O-desmethylpimobendan; Heart failure
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 29, 2024

2023 journal article

Revision of fluoroquinolone breakpoints used for interpretation of antimicrobial susceptibility testing of canine bacterial isolates

AMERICAN JOURNAL OF VETERINARY RESEARCH, 84(11).

By: M. Papich n, L. Gunnett* & B. V. Lubbers*

author keywords: antibiotic; enrofloxacin; marbofloxacin; dogs; susceptibility testing
TL;DR: The Clinical and Laboratory Standards Institute (CLSI) Veterinary Antimicrobial Susceptibility Testing Subcommittee (VAST) revised its antimicrobial susceptibility testing breakpoints and will likely reduce the unnecessary use of these fluoroquinolones in dogs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 2, 2024

2023 journal article

THE PHARMACOKINETICS AND PHARMACODYNAMICS OF ORAL PONAZURIL IN THE TREATMENT OF SYSTEMIC ISOSPOROSIS IN PASSERINE BIRDS

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 54(3), 561–572.

By: M. McEntire*, J. Landolfi*, M. Adkesson*, M. Papich n, S. Sander*, L. Roy*, A. Talley*, L. Vincent*, M. Allender*

TL;DR: Results support that treatment of breeding birds with 100 mg/kg ponazuril could reduce the shedding of active oocysts and decrease risk of clinical infection in susceptible juveniles. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 13, 2023

2022 article

Ceftazidime pharmacokinetics in dogs after intravenous injection and delivered with the RxActuator Mini-Infuser infusion pump

Papich, M. G., Madsen, M., Messenger, K., & Enomoto, H. (2022, May 6). JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, Vol. 5.

By: M. Papich n, M. Madsen n, K. Messenger n & H. Enomoto n

author keywords: antimicrobial; canine; cephalosporin; half-life; mean inhibitory concentration
MeSH headings : Animals; Ceftazidime / pharmacokinetics; Dogs; Humans; Infusion Pumps / veterinary; Infusions, Intravenous / veterinary; Injections, Intravenous / veterinary
TL;DR: This study demonstrated the successful application of the RxActuator Mini-Infuser wearable SC constant rate infusion pump for delivering an antimicrobial needed for serious, and sometimes resistant, infections in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 7, 2022

2022 journal article

Effects of housing environment on oral absorption of acetaminophen in healthy Beagles

AMERICAN JOURNAL OF VETERINARY RESEARCH, 83(1), 80–85.

By: M. Madsen n, H. Enomoto n, K. Messenger n & M. Papich n

MeSH headings : Acetaminophen; Animals; Cross-Over Studies; Dogs; Gastric Emptying; Housing
TL;DR: It is suggested that in dogs, housing environment (normal environment vs a cage in an unfamiliar environment) did not significantly affect oral absorption and, by extension, gastric emptying of acetaminophen. (via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 7, 2022

2022 journal article

Gastrointestinal transit time is faster in Beagle dogs compared to cats

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 260, S8–S14.

By: M. Tolbert*, N. Telles*, B. Simon*, E. Scallan*, J. Price*, E. Gould*, M. Papich n, J. Lidbury*, J. Steiner*, A. Kathrani*

MeSH headings : Dogs; Cats; Animals; Gastrointestinal Transit; Cat Diseases; Dog Diseases; Gastrointestinal Tract; Stomach
TL;DR: GITT is faster in Beagles compared to cats, but gastrointestinal pH are similar when fed the same diet. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 17, 2023

2022 article

Impact of gastrointestinal differences in veterinary species on the oral drug solubility, in vivo dissolution, and formulation of veterinary therapeutics

Martinez, M. N., Papich, M. G., & Fahmy, R. (2022, January 1). ADMET AND DMPK, Vol. 1.

By: M. Martinez*, M. Papich n & R. Fahmy*

author keywords: veterinary; gastrointestinal physiology; formulation considerations; solubility
TL;DR: These discussions are framed around some of the basic principles associated with drug solubilization, reported species differences in GI fluid composition, types of oral dosage forms typically given for the various animal species, and the effect of prandial state in dogs and cats. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 3, 2022

2022 journal article

PHARMACOKINETICS OF A SINGLE DOSE OF INTRAMUSCULAR AND ORAL MELOXICAM IN YELLOW STINGRAYS (UROBATIS JAMAICENSIS)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 53(1), 153–158.

By: L. Kane*, . Matthew R. O'Connor* & M. Papich n

MeSH headings : Animals; Area Under Curve; Half-Life; Meloxicam; Skates, Fish; Thiazines; Thiazoles
TL;DR: The recommended meloxicam dosage and frequency for yellow stingrays is 2 mg/kg orally once daily, and due to rapid elimination with the intramuscular administration, maintaining clinically relevant plasma concentrations may be difficult using this route. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2022

2022 journal article

PHARMACOKINETICS OF RECTALLY AND ORALLY ADMINISTERED LEVOFLOXACIN IN ASIAN ELEPHANTS (ELEPHAS MAXIMUS)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 53(4), 670–678.

By: J. Kilburn*, D. Schmitt, W. Kiso, M. Papich n & K. Backues*

MeSH headings : Animals; Elephants; Levofloxacin; Area Under Curve; Anti-Bacterial Agents; Anti-Infective Agents
TL;DR: Based on findings, levofloxacin may be a consideration for administration orally and rectally in Asian elephants and antimicrobial stewardship principles, culture and susceptibility of suspected pathogens, and blood level monitoring should be used to tailor administration of lev ofloxicin in this species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 13, 2023

2022 journal article

Update on withdrawal intervals following extralabel use of procaine penicillin G in cattle and swine

Journal of the American Veterinary Medical Association, 260(1), 50–55.

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Cattle; Drug Residues; Penicillin G Procaine / therapeutic use; Swine
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 7, 2022

2022 journal article

Veterinary antimicrobial prescribing practices for treatment of presumptive sporadic urinary tract infections in dogs examined at primary care practices in the United States (2010-2019)

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 260, S21–S27.

By: R. Bloch*, M. Papich n & T. Sturmer*

MeSH headings : Amoxicillin / therapeutic use; Amoxicillin-Potassium Clavulanate Combination / therapeutic use; Animals; Anti-Bacterial Agents / therapeutic use; Dog Diseases / drug therapy; Dogs; Primary Health Care; United States; Urinary Tract Infections / drug therapy; Urinary Tract Infections / epidemiology; Urinary Tract Infections / veterinary
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: June 13, 2022

2021 journal article

Ampicillin pharmacokinetics in azotemic and healthy dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(2), 987–992.

By: K. Monaghan*, M. Labato* & M. Papich n

author keywords: acute kidney injury; drug concentration; half-life; plasma clearance; volume of distribution
MeSH headings : Administration, Oral; Ampicillin; Animals; Anti-Bacterial Agents; Area Under Curve; Chromatography, High Pressure Liquid / veterinary; Dogs; Half-Life; Prospective Studies
TL;DR: Increased drug concentrations and slower clearance in azotemic dogs could have clinical importance in contributing to antibiotic associated morbidity requiring indicating the need to adjust ampicillin dosing in dogs with decreased kidney function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 21, 2021

2021 journal article

Antimicrobial agent use in small animals what are the prescribing practices, use of PK‐PD principles, and extralabel use in the United States?

Journal of Veterinary Pharmacology and Therapeutics.

By: M. Papich n

author keywords: antibacterial; antibiotics; antiinfective; companion animal; pharmacokinetics
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Anti-Infective Agents / therapeutic use; Cat Diseases / drug therapy; Cats; Dog Diseases / drug therapy; Dogs; Humans; United States; Veterinarians
TL;DR: There is a need for incentives to approve new agents that will be more appropriate for treating infections in companion animals without increasing the risk of drug-resistant bacteria that could potentially be transferred to humans and the environment and create a public health risk. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: October 24, 2020

2021 review

CEFOVECIN PROTEIN BINDING AS A PREDICTOR FOR EXTENDED DURATION OF ACTION: A REVIEW OF CURRENT LITERATURE AND IN VITRO ANALYSIS IN MULTIPLE ZOOLOGICAL SPECIES

[Review of ]. JOURNAL OF ZOO AND WILDLIFE MEDICINE, 52(4), 1185–1194.

By: M. Valitutto*, J. Yu*, B. Raphael*, P. Calle*, J. Sykes*, J. Pare*, R. Moore*, M. Papich n

MeSH headings : Animals; Anti-Bacterial Agents; Cat Diseases; Cats; Cephalosporins; Dog Diseases; Dogs; Injections, Subcutaneous / veterinary; Protein Binding
TL;DR: It is suggested that a high percentage of plasma protein binding in vitro may predict in which species cefovecin may exhibit a long half-life and duration of action in vivo, and may aid in selecting species for cef Covecin pharmacokinetic research and for empirical treatment of infections caused by susceptible bacteria. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2022

2021 journal article

Cefovecin pharmacokinetics after single-dose intramuscular administration in cheetahs (Acinonyx jubatus)

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 44(5), 829–835.

By: J. Yu*, M. Papich n, R. Torres, J. Emerson*, M. Kinney*, K. Helmick*, A. Crosier*, C. Sanchez*, S. Murray*

author keywords: Acinonyx; cefovecin; cephalosporins; pharmacokinetics
MeSH headings : Acinonyx; Animals; Anti-Bacterial Agents; Cephalosporins; Injections, Intramuscular / veterinary
TL;DR: Results indicate that cefovecin is potentially useful as a long-acting antibiotic in cheetahs, and was highly protein-bound in Cheetah plasma, which is nearly identical to domestic cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 19, 2021

2021 journal article

Clinical Outcome of Transcervical Infusion of a Combination of Procaine Penicillin and Gentamicin in Late-term Pregnant Mares

JOURNAL OF EQUINE VETERINARY SCIENCE, 106.

By: T. Beachler n, M. Papich n, N. Andrews n, K. Dollen n, K. Ellis n, K. Withowski n, C. Bailey n

author keywords: Equine; Mare; Pregnant; Penicillin; Gentamicin; Antibiotics
MeSH headings : Animals; Female; Gentamicins; Horses; Penicillin G Procaine; Placenta; Pregnancy; Pregnancy Outcome / veterinary; Uterus
TL;DR: Two out of nine foals displayed signs of mild neonatal maladjustment syndrome that responded to minimal supportive care and all foals survived to weaning without further complications after transcervical intrauterine infusion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 18, 2021

2021 journal article

Effects of danofloxacin dosing regimen on gastrointestinal pharmacokinetics and fecal microbiome in steers

SCIENTIFIC REPORTS, 11(1).

By: J. Halleran n, B. Callahan n, M. Jacob n, H. Sylvester n, T. Prange n, M. Papich n, D. Foster n

MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Cattle; Enterococcus / drug effects; Escherichia coli / drug effects; Fluoroquinolones / pharmacology; Gastrointestinal Microbiome / drug effects; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / microbiology; Male
TL;DR: Danofloxacin treatment consistently resulted in the Euryarchaeota phyla decreasing over time, specifically due to a decrease in Methanobrevibacter, and although microbiome differences were minor between dosing groups, the low dose group had a higher number of isolates with MIC values high enough to cause clinically relevant resistance. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 26, 2021

2021 article

Evaluation of gastrointestinal transit times and pH in healthy cats using a continuous pH monitoring system

Telles, N. J., Simon, B. T., Scallan, E. M., Gould, E. N., Papich, M. G., He, Y., … Tolbert, M. K. (2021, December 8). JOURNAL OF FELINE MEDICINE AND SURGERY, Vol. 12.

By: N. Telles*, B. Simon*, E. Scallan*, E. Gould*, M. Papich n, Y. He n, M. Lee n, J. Lidbury* ...

author keywords: Motility; residence time; gastric transit; intestinal transit
MeSH headings : Administration, Oral; Animals; Cats; Female; Gastrointestinal Transit; Hydrogen-Ion Concentration; Intestine, Small; Time Factors
TL;DR: Gastric and intestinal pH differed significantly when the capsule was administered 5’h prior to feeding compared with 1 h after feeding, and transit times for both periods showed high degrees of intra- and inter-individual variability. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 20, 2021

2021 journal article

Evaluation of urine concentrations of amoxicillin and clavulanate in cats

Journal of Veterinary Internal Medicine.

By: K. KuKanich*, K. Woodruff*, Z. Bieberly*, M. Papich n & B. KuKanich*

author keywords: antimicrobial; pharmacokinetic; stewardship; urinary tract infection
MeSH headings : Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents / therapeutic use; Clavulanic Acid; Dogs; Escherichia coli; Microbial Sensitivity Tests / veterinary
TL;DR: New CLSI uropathogen susceptibility breakpoints for amoxicillin and amoxicillin‐clavulanate in healthy cats are suggested to be increased, increasing the urine breakpoint from ≤0.25 to ≤8 μg/mL. (via Semantic Scholar)
Source: ORCID
Added: December 7, 2020

2021 journal article

Investigation of the Bi-Weekly Administration of Diclazuril on the Antibody Kinetics to Sarcocystis Neurona in Healthy Horses

JOURNAL OF EQUINE VETERINARY SCIENCE, 104.

By: N. Pusterla*, K. James*, F. Bain, D. Barnett, D. Chappell, E. Gaughan, B. Craig, C. Schneider, W. Vaala, M. Papich n

author keywords: EPM; S; neurona; Diclazuril; Antibody titers; Healthy horses
MeSH headings : Animals; Antibodies; Horse Diseases; Horses; Kinetics; Nitriles; Sarcocystis; Sarcocystosis / veterinary; Seroepidemiologic Studies; Triazines
TL;DR: The administration of diclazuril pelleted top dress at half the label dose twice weekly was able to maintain low titers to S. neurona in healthy adult horses naturally exposed to the protozoal parasite. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 20, 2021

2021 article

Naloxone and nalmefene absorption delivered by hollow microneedles compared to intramuscular injection

Papich, M. G., & Narayan, R. J. (2021, November 24). DRUG DELIVERY AND TRANSLATIONAL RESEARCH, Vol. 11.

By: M. Papich n & R. Narayan n

author keywords: Microneedle; Opioid; Overdose; Naloxone; Nalmefene
MeSH headings : Analgesics, Opioid; Animals; Cross-Over Studies; Dogs; Humans; Injections, Intramuscular; Naloxone; Naltrexone / analogs & derivatives; Naltrexone / pharmacokinetics; Naltrexone / therapeutic use; Narcotic Antagonists
TL;DR: These studies were designed to test the feasibility of using the hollow microneedle array as an effective method of naloxone and nalmefene delivery for emergency treatment of opioid-induced respiratory depression (OIRD) in people. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 25, 2021

2021 article

Naloxone and nalmefene absorption delivered by hollow microneedles compared to intramuscular injection

Papich, M. G., & Narayan, R. J. (2021, September 30).

By: M. Papich n & R. Narayan n

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 1, 2021

2021 journal article

PHARMACOKINETICS OF A SINGLE ORAL DOSE OF PONAZURIL IN THE INDIAN PEAFOWL (PAVO CRISTATUS)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 52(2), 548–554.

By: S. Zec*, M. Papich n, D. Oehler*, K. Hills*, S. Schmid*, K. Huth*, D. Dodge*, J. Pare*

MeSH headings : Administration, Oral; Animals; Coccidiostats / blood; Coccidiostats / chemistry; Coccidiostats / pharmacokinetics; Dose-Response Relationship, Drug; Feces / chemistry; Female; Galliformes / metabolism; Male; Triazines / blood; Triazines / chemistry; Triazines / pharmacokinetics
TL;DR: Ponazuril in peafowl was well absorbed orally, plasma concentrations increased with dose, and elimination was slower than current dosages for birds would suggest. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 12, 2021

2021 journal article

PHARMACOKINETICS OF SUBCUTANEOUS ALPHA LIPOIC ACID, A PROPOSED THERAPEUTIC AID FOR DOMOIC ACID INTOXICATION IN CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 52(3), 872–879.

By: C. Field, S. Whoriskey, X. Zhao & M. Papich*

MeSH headings : Animals; Kainic Acid / analogs & derivatives; Kainic Acid / toxicity; Neurotoxins; Sea Lions; Thioctic Acid
TL;DR: Therapeutic effects are noted with a CMAX of 4,000 to 5,000 ng/ml in humans; thus in CSLs, 20 mg/kg administered subcutaneously once daily may be sufficient to achieve a therapeutic level in this species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 15, 2021

2021 journal article

POPULATION PHARMACOKINETICS OF CEFTAZIDIME AFTER A SINGLE SUBCUTANEOUS INJECTION AND NORMAL ORAL AND CLOACAL BACTERIAL FLORA SURVEY IN EASTERN HELLBENDERS (CRYPTOBRANCHUS ALLEGANIENSIS ALLEGANIENSIS)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 52(1), 90–96.

By: K. Musgrave*, C. Hanley* & M. Papich n

MeSH headings : Amphibians / blood; Amphibians / metabolism; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Ceftazidime / administration & dosage; Ceftazidime / blood; Ceftazidime / pharmacokinetics; Cloaca / microbiology; Half-Life; Injections, Subcutaneous; Mouth / microbiology; Pilot Projects
TL;DR: It is indicated that ceftazidime is an appropriate choice of antibiotic in hellbenders and when given at a dosage of 20 mg/kg subcutaneously, maintains concentrations above the MIC of susceptible bacteria for up to 5 days. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 24, 2021

2021 journal article

Patterns of antimicrobial drug use in veterinary primary care and specialty practice: A 6-year multi-institution study

JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(3), 1496–1508.

By: R. Goggs*, J. Menard*, C. Altier*, K. Cummings*, M. Jacob n, D. Lalonde-Paul*, M. Papich n, K. Norman* ...

author keywords: antibiotic; antimicrobial drug; antimicrobial prescribing practices; antimicrobial prescription
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Anti-Infective Agents / therapeutic use; Cat Diseases / drug therapy; Cats; Dog Diseases / drug therapy; Dogs; Drug Prescriptions / veterinary; Pharmaceutical Preparations; Primary Health Care; Retrospective Studies
TL;DR: To quantify companion animal AMD prescribing in primary care and specialty practice across 3 academic veterinary hospitals with particular focus on third‐generation cephalosporins, fluoroquinolones, and carbapenems, a retrospective study is conducted. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 5, 2021

2021 journal article

Pharmacokinetics of doxycycline in dogs

Journal of Veterinary Pharmacology and Therapeutics.

By: M. Papich n

MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents; Dogs; Doxycycline
UN Sustainable Development Goal Categories
Source: ORCID
Added: December 25, 2020

2021 journal article

Pharmacokinetics of ketorolac in juvenile loggerhead sea turtles (Caretta caretta) after a single intramuscular injection

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 44(4), 583–589.

By: T. Gregory n, C. Harms n, M. Gorges n, G. Lewbart n & M. Papich n

author keywords: Caretta caretta; Ketorolac; loggerhead sea turtle; nonlinear mixed effects model; pharmacokinetics
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Injections, Intramuscular / veterinary; Ketorolac; Turtles
TL;DR: It is concluded that ketorolac may not be an appropriate long-term analgesic for use in loggerhead sea turtles at this dose; however, it may have some benefit as a short- term analgesic. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 21, 2021

2021 article

Phenylbutazone pharmacokinetics in southern white rhinoceros (Ceratotherium simum simum) after oral administration

Houck, E. L., Papich, M. G., & Delk, K. W. (2021, December 11). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 12.

By: E. Houck n, M. Papich n & K. Delk*

author keywords: analgesia; Ceratotherium simum; pharmacokinetics; phenylbutazone; rhinoceros
MeSH headings : Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Horses; Perissodactyla; Phenylbutazone
TL;DR: This study represents the first pharmacokinetic data of phenylbutazone in any rhinoceros species and shows concentrations achieved were similar to what has been reported for horses and were within the half maximal effective concentration for horses for at least 10 h. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 12, 2021

2021 journal article

SAFETY OF MULTIPLE-DOSE INTRAMUSCULAR KETOPROFEN TREATMENT IN LOGGERHEAD TURTLES (CARETTA CARETTA)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 52(1), 126–132.

By: C. Harms n, L. Ruterbories n, N. Stacy*, E. Christiansen n, M. Papich n, A. Lynch n, A. Barratclough*, M. Serrano n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Drug Administration Schedule; Ketoprofen / administration & dosage; Ketoprofen / adverse effects; Ketoprofen / therapeutic use; Thrombelastography; Turtles / blood
TL;DR: Ketoprofen at 2 mg/kg IM q24hr for up to 5 days in loggerheads appears safe with respect to blood clotting and blood data, although other potential effects were not evaluated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 24, 2021

2020 journal article

Capsule endoscopy detects insufficient treatment of gastric bleeding in a dog with chronic hepatitis

VETERINARY RECORD CASE REPORTS, 8(4).

By: M. Tolbert*, A. Spencer n, A. Lynch n, M. Papich n & J. Lidbury*

author keywords: omeprazole; canine; rivaroxaban; portal hypertension
TL;DR: Substantial upper GI bleeding persisted despite excellent gastric acid suppression, bringing into question the value of routinely recommending such therapy in dogs with hepatic failure without additional monitoring for adequacy of treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 24, 2020

2020 journal article

Effect of diphenhydramine and cetirizine on immediate and late-phase cutaneous allergic reactions in healthy dogs: a randomized, double-blinded crossover study

VETERINARY DERMATOLOGY, 31(4), 256-+.

By: F. Banovic*, T. Denley*, A. Blubaugh*, I. Scheibe*, N. Lemo* & M. Papich n

MeSH headings : Animals; Cetirizine / therapeutic use; Cross-Over Studies; Diphenhydramine / therapeutic use; Dog Diseases / drug therapy; Dogs; Double-Blind Method; Histamine / administration & dosage; Histamine H1 Antagonists / administration & dosage; Hypersensitivity / drug therapy; Hypersensitivity / veterinary; Male; Skin / drug effects; Skin / pathology; Skin Tests; p-Methoxy-N-methylphenethylamine / administration & dosage
TL;DR: Oral cetirizine was effective in preventing cutaneous allergic reactions without any obvious adverse effects in dogs and oral DPH failed to show an inhibitory effect despite attaining plasma drug concentrations that are considered effective in people. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 27, 2020

2020 journal article

Evaluation of bioabsorbable calcium sulfate hemihydrate beads for local delivery of carboplatin

PLOS ONE, 15(11), e0241718.

By: M. Traverson n, C. Stewart n & M. Papich n

Ed(s): S. Clegg

MeSH headings : Absorbable Implants; Animals; Calcium Sulfate / chemistry; Carboplatin / chemistry; Carboplatin / pharmacology; Cats; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Chromatography, High Pressure Liquid; Dogs; Microspheres; Neoplasms / drug therapy; Neoplasms / veterinary; Particle Size; Pilot Projects; Veterinary Medicine
TL;DR: The novel kit can be used for preparation of carboplatin-impregnated resorbable calcium sulfate beads at variable doses, sizes and formulations and higher peak concentrations, percentages released, and elution rates were observed with the liquid formulation and with highercarboplatin doses. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: January 11, 2021

2020 personal communication

Expert Opinion on Verification of Antimicrobial Susceptibility Tests

Patel, J. B., Thomson, R. B., Alby, K., Babady, E., Culbreath, K., Galas, M. F., … Schuetz, A. N. (2020, November).

By: J. Patel*, R. Thomson*, K. Alby*, E. Babady*, K. Culbreath*, M. Galas*, S. Lockhart*, B. Lubbers* ...

author keywords: CLIA; antibiotic; antifungal susceptibility testing; antimicrobial; verification
MeSH headings : Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Anti-Infective Agents / pharmacology; Expert Testimony; Humans; Microbial Sensitivity Tests; Pseudomonas Infections / drug therapy
TL;DR: The Expert Panel on Microbiology would like to respond to the recent commentary by Kirby and colleagues voicing concerns related to verification of commercial antimicrobial susceptibility testing for new drugs that are introduced into the clinical laboratory. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020

2020 journal article

PHARMACOKINETICS OF A SINGLE DOSE OF FLURALANER ADMINISTERED ORALLY TO AMERICAN BLACK BEARS (URSUS AMERICANUS)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 51(3), 691–695.

By: P. Van Wick*, M. Papich n, B. Hashem & E. Dominguez-Villegas

MeSH headings : Acaricides / pharmacokinetics; Administration, Oral; Animals; Half-Life; Isoxazoles / pharmacokinetics; Plasma / chemistry; Ursidae / blood
TL;DR: Administration of a single oral dose of fluralaner may be a viable treatment option for captive and free-ranging black bears affected by mange and it was estimated that the average drug withdrawal time is approximately 64–72 days in this species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 8, 2021

2020 journal article

Pharmacokinetics of Ketoprofen in Nile Tilapia (Oreochromis niloticus) and Rainbow Trout (Oncorhynchus mykiss)

FRONTIERS IN VETERINARY SCIENCE, 7.

By: W. Greene*, N. Mylniczenko*, T. Storms*, C. Burns*, G. Lewbart n, L. Byrd*, M. Papich n

author keywords: ketoprofen; teleost; tilapia; rainbow trout; pharmacokinctics; non-steroidal anti-inflammatory drugs (NSAIDs); Oncorhynchus mykiss; Oreochromis niloticus
TL;DR: There were very high plasma concentrations of ketoprofen in trout and tilapia with no adverse effects observed, and future studies on the efficacy, frequency of dosing, analgesia, adverse effects, and route of administration are warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020

2020 journal article

Plasma concentrations of itraconazole following a single oral dose in juvenile California sea lions (Zalophus californianus)

Journal of Veterinary Pharmacology and Therapeutics.

By: G. Scott n, C. Field*, M. Papich n & C. Harms n

author keywords: California sea lion; itraconazole; pharmacokinetics; Zalophus californianus
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Female; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics; Male; Sea Lions / blood; Sea Lions / metabolism; Species Specificity
TL;DR: Data indicate that a single oral dose of itraconazole given as a capsule at 5-10 mg/kg, under the conditions used in this study, does not achieve therapeutic plasma concentrations in California sea lions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: ORCID
Added: April 15, 2020

2020 journal article

Population pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in clinically diseased or injured Eastern box turtles (Terrapene carolina carolina), yellow‐bellied sliders (Trachemys scripta scripta), and river cooters (Pseudemys concinna)

Journal of Veterinary Pharmacology and Therapeutics.

By: J. Griffioen n, G. Lewbart n & M. Papich n

author keywords: ciprofloxacin; enrofloxacin; population; subcutaneous injection; turtles
MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Ciprofloxacin / blood; Ciprofloxacin / metabolism; Ciprofloxacin / pharmacokinetics; Enrofloxacin / blood; Enrofloxacin / metabolism; Enrofloxacin / pharmacokinetics; Female; Half-Life; Injections, Subcutaneous; Male; Turtles / blood
TL;DR: Results indicate variable pharmacokinetic parameters for enrofloxacin among turtle species, which will help guide appropriate dosing protocols in injured turtles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: February 13, 2020

2020 journal article

Preliminary Pilot Study of Itraconazole After a Single Oral Dose of a Veterinary Formulation Solution in African Penguins (Spheniscus demersus)

JOURNAL OF AVIAN MEDICINE AND SURGERY, 34(1), 52–56.

By: S. Zalesak*, C. Sanchez*, A. Pich* & M. Papich n

author keywords: plasma concentration; itraconazole; avian; African penguin; Spheniscus demersus
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Aspergillosis / drug therapy; Aspergillosis / veterinary; Bird Diseases / drug therapy; Drug Compounding / veterinary; Female; Half-Life; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics; Male; Pilot Projects; Spheniscidae / metabolism
TL;DR: Encouraging evidence is demonstrated that the FDA-approved formulation of oral itraconazole solution should be considered for future study as a cost-effective treatment for aspergillosis in African penguins and other avian species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020

2020 journal article

Role of electrolyte concentrations and renin‐angiotensin‐aldosterone activation in the staging of canine heart disease

Journal of Veterinary Internal Medicine.

By: D. Adin*, K. Kurtz n, C. Atkins n, M. Papich n & S. Vaden n

author keywords: ACVIM; congestive heart failure; diuretic; refractory
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Diuretics / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / metabolism; Dogs; Electrolytes / blood; Heart Diseases / classification; Heart Diseases / drug therapy; Heart Diseases / metabolism; Heart Diseases / veterinary; Kidney Function Tests; Pyridazines / therapeutic use; Renin-Angiotensin System / physiology; Spironolactone / therapeutic use
TL;DR: Hypochloremia is a useful marker for stage D HD in dogs, and greater RAAS inhibition in stage D versus stage C indicates effectiveness of RAAS‐suppressive treatments in this group of dogs with refractory CHF. (via Semantic Scholar)
Source: ORCID
Added: November 27, 2019

2020 journal article

The effect of combined carprofen and omeprazole administration on gastrointestinal permeability and inflammation in dogs

Journal of Veterinary Internal Medicine.

By: S. Jones n, A. Gaier n, H. Enomoto n, P. Ishii*, R. Pilla*, J. Price*, J. Suchodolski*, J. Steiner* ...

author keywords: canine; dysbiosis; nonsteroidal anti-inflammatory drug; proton pump inhibitor
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Carbazoles; Dog Diseases / chemically induced; Dog Diseases / drug therapy; Dog Diseases / prevention & control; Dogs; Female; Inflammation / chemically induced; Inflammation / drug therapy; Inflammation / veterinary; Male; Omeprazole / pharmacology; Permeability; Prospective Studies
TL;DR: Omeprazole prophylaxis induces fecal dysbiosis and increases intestinal inflammatory markers when coadministered with carprofen to otherwise healthy dogs with no other risk factors for GI bleeding. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: September 9, 2020

2020 journal article

Use of intravenous lipid therapy in a cat with carprofen overdose

CLINICAL CASE REPORTS, 8(4), 653–657.

By: N. Chumbler*, J. Schildt*, D. Mawby* & M. Papich n

author keywords: feline toxicosis; intravenous lipids; NSAID overdose
TL;DR: It is postulates that ILE can be used for the treatment of carprofen toxicity in cats and supports the lipid sink theory as the main mechanism of action. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 16, 2020

2019 journal article

Antimicrobial Activity of Ceftiofur and Penicillin With Gentamicin Against Escherichia coli and Streptococcus equi Subspecies zooepidemicus in an Ex Vivo Model of Equine Postpartum Uterine Disease

JOURNAL OF EQUINE VETERINARY SCIENCE, 79, 121–126.

By: K. Von Dollen n, M. Jones n, T. Beachler n, T. Harris n, M. Papich n, S. Lyle n, C. Bailey n

author keywords: E. coli; S. zooepidemicus; Postpartum mare; Antibiotic use
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Cephalosporins; Drug Resistance, Bacterial; Escherichia coli; Female; Gentamicins; Horse Diseases / drug therapy; Horses; Humans; Penicillins; Postpartum Period; Streptococcus equi; Uterine Diseases / drug therapy; Uterine Diseases / veterinary
TL;DR: The intrauterine infusion of procaine penicillin G with gentamicin in cases of postpartum uterine disease caused by E. coli or S. zooepidemicus is supported by the results of this work. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2019

2019 journal article

Ceftiofur formulation differentially affects the intestinal drug concentration, resistance of fecal Escherichia coli, and the microbiome of steers

PLOS ONE, 14(10).

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacokinetics; Cattle; Cattle Diseases / drug therapy; Cattle Diseases / microbiology; Cephalosporins / administration & dosage; Cephalosporins / chemistry; Cephalosporins / pharmacokinetics; Drug Resistance, Bacterial; Escherichia coli / classification; Escherichia coli / drug effects; Escherichia coli / genetics; Feces / microbiology; Microbial Sensitivity Tests; Microbiota; RNA, Ribosomal, 16S / genetics
TL;DR: CCFA leads to prolonged, low intestinal drug concentrations, and is associated with decreased E. coli concentration, an increased MIC of ceftiofur in E. Escherichia coli at specific time points, and shifts in the fecal microbiota. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020

2019 journal article

Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study

VETERINARY DERMATOLOGY, 30(2), 91-+.

By: S. Ehling n, W. Baeumer & M. Papich n

MeSH headings : Administration, Intravenous; Administration, Oral; Animals; Cross-Over Studies; Dimenhydrinate / administration & dosage; Dimenhydrinate / blood; Dimenhydrinate / pharmacokinetics; Diphenhydramine / administration & dosage; Diphenhydramine / blood; Diphenhydramine / pharmacokinetics; Dogs; Female; Half-Life; Histamine / adverse effects; Histamine Antagonists / pharmacokinetics; Male; Pilot Projects; Theophylline / blood; Urticaria / chemically induced; Urticaria / drug therapy
TL;DR: Oral absorption of diphenhydramine was approximately three times greater with a longer half-life when it was administered as the combination product dimenhydrinate, and theophylline reached plasma concentrations considered to be therapeutic for dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2019 journal article

Enrofloxacin Pharmacokinetics and Sampling Techniques in California Sea Hares (Aplysia californica)

Journal of the American Association for Laboratory Animal Science, 58(2), 231–234.

By: S. Mason n, M. Papich n, M. Schmale*, C. Harms n & S. Davis*

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Aplysia / metabolism; Chromatography, High Pressure Liquid; Enrofloxacin / administration & dosage; Enrofloxacin / pharmacokinetics; Laboratory Animal Science
TL;DR: Hemocoel injection appears to be an effective way to administer enrofloxacin to Aplysia and reach clinically relevant concentrations, and reached therapeutic target concentrations in A. californica when dosed according to the regimen described in the current report. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 22, 2019

2019 journal article

Evaluation of Transdermal Administration of Phenobarbital in Healthy Cats

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 55(1), 1–7.

By: D. Krull n, S. Thomovsky n, A. Chen n, K. Mealey n & M. Papich n

MeSH headings : Administration, Cutaneous; Animals; Cats / blood; Cats / metabolism; Dose-Response Relationship, Drug; Drug Monitoring; Female; Gels; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / adverse effects; Hypnotics and Sedatives / pharmacokinetics; Male; Phenobarbital / administration & dosage; Phenobarbital / adverse effects; Phenobarbital / pharmacokinetics
TL;DR: Transdermal application of phenobarbital in healthy cats achieves a detectable, but subtherapeutic, serum concentration and appears safe in the short term and the use of therapeutic drug monitoring is recommended to ensure therapeutic serum concentrations are achieved. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 31, 2018

2019 journal article

International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats

VETERINARY JOURNAL, 247, 8–25.

By: J. Weese*, J. Blondeau*, D. Boothe*, L. Guardabassi*, N. Gumley*, M. Papich n, L. Jessen*, M. Lappin* ...

author keywords: Antimicrobials; Cystitis; Prostatitis; Pyelonephritis; Antimicrobial stewardship
MeSH headings : Animals; Bacterial Infections / diagnostic imaging; Bacterial Infections / drug therapy; Bacterial Infections / therapy; Bacterial Infections / veterinary; Cat Diseases / diagnosis; Cat Diseases / therapy; Cats; Dog Diseases / diagnosis; Dog Diseases / therapy; Dogs; Pets; Urinary Tract Infections / diagnosis; Urinary Tract Infections / therapy; Urinary Tract Infections / veterinary
TL;DR: This document is a revision and expansion on the 2011 Antimicrobial Use Guidelines for Treatment of Urinary Tract Disease in Dogs and Cats, providing recommendations for diagnosis and management of sporadic bacterial cystitis, recurrent bacterial cyStitis, pyelonephritis, bacterial prostatitis, and subclinical bacteriuria. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 20, 2019

2019 journal article

Pharmacokinetics of levofloxacin following oral administration of a generic levofloxacin tablet and intravenous administration to dogs

AMERICAN JOURNAL OF VETERINARY RESEARCH, 80(10), 957–962.

By: M. Madsen n, K. Messenger n & M. Papich n

MeSH headings : Administration, Intravenous; Administration, Oral; Animals; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid / veterinary; Cross-Over Studies; Dogs / metabolism; Female; Half-Life; Levofloxacin / administration & dosage; Levofloxacin / pharmacokinetics; Male; Tablets
TL;DR: In these dogs, levofloxacin was well absorbed when administered orally, and a dose of approximately 25 mg/kg was sufficient to reach pharmacokinetic-pharmacodynamic targets for treating infections with susceptible Enterobacteriaceae or Pseudomonas aeruginosa. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020

2019 journal article

Pharmacokinetics of orally administered tramadol in Muscovy ducks (Cairina moschata domestica)

Journal of Veterinary Pharmacology and Therapeutics, 1.

By: R. Bailey*, J. Sheldon*, M. Allender*, M. Papich n & S. Chinnadurai*

author keywords: analgesia; duck; O-desmethyl-tramadol; tramadol
MeSH headings : Administration, Oral; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Area Under Curve; Ducks / blood; Half-Life; Tramadol / administration & dosage; Tramadol / blood; Tramadol / pharmacokinetics
TL;DR: This study documents the pharmacokinetics of oral tramadol in Muscovy ducks using a one-compartment model with first-order input to estimate half-life and pharmacokinetic parameters. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: February 27, 2019

2019 journal article

Plasma Bleomycin Concentrations during Electrochemotherapeutic Treatment of Fibropapillomas in Green Turtles Chelonia mydas

JOURNAL OF AQUATIC ANIMAL HEALTH, 31(2), 186–192.

By: K. Donnelly*, M. Papich n, B. Zirkelbach*, T. Norton*, A. Szivek*, B. Burkhalter*, J. Impellizeri, N. Stacy*

MeSH headings : Animals; Bleomycin / blood; Electrochemotherapy / statistics & numerical data; Electrochemotherapy / veterinary; Papilloma / therapy; Papilloma / veterinary; Plasma / chemistry; Turtles / blood
TL;DR: This study adds further support that electrochemotherapy with bleomycin has the potential to be used as an effective alternative treatment for this complex disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 8, 2019

2019 journal article

Population Pharmacokinetics of Danofloxacin After Single Intramuscular Dose Administration in California Brown Pelicans (Pelecanus occidentalis californicus)

JOURNAL OF AVIAN MEDICINE AND SURGERY, 33(4), 361–368.

author keywords: danofloxacin; pharmacokinetics; avian; brown pelican; Pelecanus occidentalis californicus
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Birds / metabolism; Chromatography, High Pressure Liquid / veterinary; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Half-Life; Injections, Intramuscular / veterinary; Intramuscular Absorption; Microbial Sensitivity Tests / veterinary; Nonlinear Dynamics; Pectoralis Muscles / metabolism
TL;DR: The intramuscular injection of danofloxacin in pelicans at this dose produced plasma concentrations that meet therapeutic targets for bacteria with a minimum inhibitory concentration of ≤0.25 µg/mL, which can be used for future studies to evaluate the efficacy of dan ofloxicin for treating susceptible bacteria. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 30, 2019

2019 journal article

Population pharmacokinetics of itraconazole solution after a single oral administration in captive lesser flamingos (Phoeniconaias minor)

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 42(1), 1–6.

By: C. Sanchez*, S. Zalesak*, A. Pich* & M. Papich n

MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Birds / blood; Birds / metabolism; Female; Half-Life; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics; Male
TL;DR: It was concluded that plasma drug concentrations of itraconazole were maintained in a population of flamingos above 0.5 ug/ml for at least 24 hr after a single oral dose of 10 mg/kg of it rconazole solution. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 21, 2019

2019 journal article

Reconciling Human-Canine Differences in Oral Bioavailability: Looking beyond the Biopharmaceutics Classification System

AAPS JOURNAL, 21(5).

By: M. Martinez*, A. El-Kattan*, E. Awji* & M. Papich n

author keywords: biopharmaceutics drug disposition classification system; dog oral bioavailability; extended clearance classification system; human oral bioavailability; interspecies extrapolation
MeSH headings : Animals; Biological Availability; Biopharmaceutics / classification; Dogs; Drug Development / methods; Humans; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / metabolism; Solubility; Species Specificity
TL;DR: It is concluded that although neither the BDDCS nor the ECCS can reliably improve the ability to determine when F will be similar in humans and dogs, the E CCS provides a mechanism to help define possible causes for observed human-canine inconsistencies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2019

2018 chapter

Immunosuppressive Drugs

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 1226–1244). Hoboken, New Jersey, USA.: Wiley Blackwell, John Wiley & Sons.

By: M. Papich

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: April 5, 2019

2018 journal article

ACVIM consensus statement: Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats

JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(6), 1803–1822.

By: M. Acierno*, S. Brown*, A. Coleman*, R. Jepson*, M. Papich n, R. Stepien*, H. Syme*

author keywords: blood pressure; cardiology; cardiovascular; chronic renal failure; hemodynamics; hypertension; kidney; proteinuria; renal/urinary tract
MeSH headings : Animals; Antihypertensive Agents / therapeutic use; Blood Pressure; Blood Pressure Determination / veterinary; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cat Diseases / etiology; Cats; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / etiology; Dogs; Hypertension / diagnosis; Hypertension / drug therapy; Hypertension / etiology; Hypertension / veterinary; Reference Values
TL;DR: An update to the 2007 American College of Veterinary Internal Medicine consensus statement on the identification, evaluation, and management of systemic hypertension in dogs and cats was presented at the 2017 ACVIM Forum in National Harbor, MD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 31, 2018

2018 journal article

ACVIM consensus statement: Support for rational administration of gastrointestinal protectants to dogs and cats

JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(6), 1823–1840.

By: S. Marks*, P. Kook*, M. Papich n, M. Tolbert* & M. Willard*

author keywords: acid; canine; feline; gastroesophageal reflux; histamine type-2 receptor antagonist; misoprostol; proton pump inhibitor; sucralfate; ulcer
MeSH headings : Animals; Cat Diseases / drug therapy; Cats; Dog Diseases / drug therapy; Dogs; Gastrointestinal Agents / administration & dosage; Gastrointestinal Agents / therapeutic use; Gastrointestinal Diseases / drug therapy; Gastrointestinal Diseases / veterinary; Misoprostol / administration & dosage; Misoprostol / therapeutic use; Proton Pump Inhibitors / administration & dosage; Proton Pump Inhibitors / therapeutic use; Sucralfate / administration & dosage; Sucralfate / therapeutic use
TL;DR: This report challenges the dogma and clinical practice of administering GI protectants for the routine management of gastritis, pancreatitis, hepatic disease, and renal disease in dogs and cats lacking additional risk factors for ulceration or concerns for GI bleeding. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 31, 2018

2018 chapter

Aminoglycoside Antibiotics

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 877–902). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.

By: M. Papich & J. Riviere

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: April 5, 2019

2018 chapter

Anticoagulant, Antiplatelet, and Hemostatic Drugs

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 625–646). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.

By: M. Papich

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: April 5, 2019

2018 chapter

Anticonvulsant Drugs

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 395–415). Hoboken, New Jersey: Wiley Blackwell, John Wiley & Sons.

By: M. Papich

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: April 5, 2019

2018 chapter

Chloramphenicol and Derivatives, Macrolides, Lincosamides, and Miscellaneous Antimicrobials

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed.). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.

By: M. Papich

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: April 5, 2019

2018 journal article

Comparison of absorption characteristics of oral reference and compounded itraconazole formulations in healthy cats

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 252(2), 195–200.

By: D. Mawby, J. Whittemore, L. Fowler & M. Papich*

MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / chemistry; Antifungal Agents / pharmacokinetics; Area Under Curve; Cats / blood; Cross-Over Studies; Dosage Forms; Half-Life; Itraconazole / administration & dosage; Itraconazole / chemistry; Itraconazole / pharmacokinetics; Random Allocation; Therapeutic Equivalency
TL;DR: Compounded oral formulations of itraconazole should not be used for cats because of poor absorption and the differences in absorption between the 2 reference formulations suggested that doses required to meet human target serum concentrations in cats are markedly different. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Diclazuril nonlinear mixed-effects pharmacokinetic modelling of plasma concentrations after oral administration to adult horses every 3-4 days

VETERINARY JOURNAL, 242, 74–76.

By: L. Hunyadi*, M. Papich n & N. Pusterla*

author keywords: Diclazuril; EPM; Prevention; Sarcocystis neurona
MeSH headings : Administration, Oral; Animals; Coccidiostats / administration & dosage; Coccidiostats / blood; Coccidiostats / pharmacokinetics; Drug Administration Schedule; Female; Horses / blood; Horses / metabolism; Male; Nitriles / administration & dosage; Nitriles / blood; Nitriles / pharmacokinetics; Triazines / administration & dosage; Triazines / blood; Triazines / pharmacokinetics
TL;DR: Low dose diclazuril pellets produce steady-state plasma drug concentrations known to inhibit S. neurona and N. caninum, according to the mean population-derived peak concentration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 31, 2018

2018 journal article

Dosing Regimen of Enrofloxacin Impacts Intestinal Pharmacokinetics and the Fecal Microbiota in Steers

Frontiers in Microbiology, 9.

By: K. Ferguson n, M. Jacob n, C. Theriot n, B. Callahan n, T. Prange n, M. Papich n, D. Foster n

author keywords: antimicrobial resistance; fluoroquinolone; cattle; microbiome; pharmacokinetics
TL;DR: Both dosing regimens of enrofloxacin achieve high concentrations in the intestinal lumen, and the rapid elimination mitigates long-term impacts on fecal E. coli resistance and the microbiota. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: October 16, 2018

2018 chapter

Drugs Affecting Animal Behavior

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 416–448). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.

By: M. Gruen, B. Sherman & M. Papich

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: April 5, 2019

2018 chapter

Drugs for Treating Gastrointestinal Diseases

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 1245–1277). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.

By: M. Papich

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: April 5, 2019

2018 chapter

Drugs that Affect the Respiratory System

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 1302–1320). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.

By: M. Papich

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: April 5, 2019

2018 chapter

Fluoroquinolone Antimicrobial Drugs

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 953–987). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.

By: M. Papich

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: April 5, 2019

2018 chapter

Opioid Analgesic Drugs

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 281–323). Hoboken, New Jersey: Wiley Blackwell, John Wiley & Sons.

By: B. KuKanich & M. Papich

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: April 5, 2019

2018 journal article

Pharmacodynamic assessment of diuretic efficacy and braking in a furosemide continuous infusion model

JOURNAL OF VETERINARY CARDIOLOGY, 20(2), 92–101.

By: D. Adin n, C. Atkins n & M. Papich n

author keywords: Lasix; Urine; Natriuresis; Aldosterone
MeSH headings : Aldosterone / urine; Animals; Diuretics / administration & dosage; Diuretics / blood; Diuretics / pharmacology; Diuretics / urine; Dogs; Electrolytes / urine; Furosemide / administration & dosage; Furosemide / blood; Furosemide / pharmacology; Furosemide / urine; Infusions, Intravenous; Male; Renin-Angiotensin System / drug effects
TL;DR: The decrease in uNa:uK over time during the infusion is consistent with mineralocorticoid modification of urinary electrolyte excretion, supporting renin-angiotensin-aldosterone activation as a cause of diuretic braking in this model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

Pharmacokinetics and Pharmacodynamics of an Oral Formulation of Apixaban in Horses After Oral and Intravenous Administration

FRONTIERS IN VETERINARY SCIENCE, 5.

By: P. Serpa*, M. Brooks*, T. Diverse, S. Ness*, I. Birschmann*, M. Papich n, T. Stokol*

author keywords: factor Xa; direct oral anticoagulant; EHV-1; platelet activation; equine
TL;DR: It is demonstrated that apixaban has no apparent clinical utility as an anticoagulant for horses due to poor oral availability. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 17, 2018

2018 journal article

Pharmacokinetics of enrofloxacin and ciprofloxacin in Atlantic horseshoe crabs (Limulus polyphemus) after single injection

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 41(2), 349–353.

By: A. Kirby n, G. Lewbart n, A. Hancock-Ronemus* & M. Papich n

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / pharmacokinetics; Ciprofloxacin / administration & dosage; Ciprofloxacin / analysis; Ciprofloxacin / pharmacokinetics; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / analysis; Fluoroquinolones / pharmacokinetics; Half-Life; Hemolymph / chemistry; Horseshoe Crabs / metabolism; Injections / veterinary; Male
TL;DR: Concentrations that were achieved after a single dose of 5 mg/kg horseshoe crabs were sufficient to treat bacteria susceptible to enrofloxacin and ciprofl oxacin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

Pharmacokinetics of furosemide after intravenous, oral and transdermal administration to cats

Journal of Feline Medicine and Surgery, 1098612X1880587.

By: M. Sleeper*, P. O’Donnell*, C. Fitzgerald* & M. Papich n

author keywords: Furosemide; pharmacokinetic; diuretic; transdermal; heart failure
MeSH headings : Administration, Cutaneous; Administration, Oral; Administration, Topical; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacokinetics; Animals; Biological Availability; Cats / metabolism; Female; Furosemide / administration & dosage; Furosemide / pharmacokinetics; Half-Life; Infusions, Intravenous / veterinary; Injections, Intravenous / veterinary; Male
TL;DR: Furosemide was rapidly eliminated in cats after oral and IV administration and is probably best administered orally at least q12h in cats with heart failure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 27, 2019

2018 journal article

Pharmacokinetics of ketorolac in wild Eastern box turtles (Terrapene carolina carolina ) after single intramuscular administration

Journal of Veterinary Pharmacology and Therapeutics, 11.

By: A. Cerreta n, C. Masterson n, G. Lewbart n, D. Dise n & M. Papich n

MeSH headings : Analgesia / methods; Analgesia / veterinary; Analgesics / administration & dosage; Analgesics / blood; Analgesics / pharmacokinetics; Animals; Chromatography, High Pressure Liquid / veterinary; Female; Half-Life; Injections, Intramuscular / veterinary; Ketorolac / administration & dosage; Ketorolac / blood; Ketorolac / pharmacokinetics; Male; Turtles / blood; Turtles / metabolism
TL;DR: It is concluded that this long T1/2 for a dose of 0.25 mg/kg ketorolac-injected IM provides plasma levels above a previously published target level for 24-hour analgesia to allow for once daily dosing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Crossref, NC State University Libraries
Added: February 11, 2019

2018 journal article

Population pharmacokinetics of ceftazidime after a single intramuscular injection in wild turtles

Journal of Veterinary Pharmacology and Therapeutics, 41(4), 495–501.

By: A. Cerreta n, G. Lewbart n, D. Dise n & M. Papich n

author keywords: ceftazidime; nonlinear mixed-effects modeling; pharmacokinetics; turtles
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Ceftazidime / administration & dosage; Ceftazidime / blood; Ceftazidime / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Injections, Intramuscular / veterinary; Turtles / blood; Turtles / metabolism
TL;DR: This investigation used a population pharmacokinetic approach to study ceftazidime in wild turtles presented for rehabilitation, and concluded that this long T½ will allow for a dose of 20 mg/kg injected IM to maintain concentrations above the MIC of most wild-type bacteria for 5 days. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2018 journal article

Population pharmacokinetics of extended-release levetiracetam in epileptic dogs when administered alone, with phenobarbital or zonisamide

Journal of Veterinary Internal Medicine, 32(5), 1677–1683.

By: K. Muñana n, A. Otamendi n, J. Nettifee n & M. Papich n

author keywords: antiepileptic drug; canine; drug disposition; drug interactions; seizures
MeSH headings : Animals; Anticonvulsants / administration & dosage; Anticonvulsants / pharmacokinetics; Anticonvulsants / therapeutic use; Delayed-Action Preparations; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Drug Interactions; Epilepsy / drug therapy; Epilepsy / veterinary; Levetiracetam / administration & dosage; Levetiracetam / pharmacokinetics; Levetiracetam / therapeutic use; Phenobarbital / administration & dosage; Phenobarbital / pharmacokinetics; Phenobarbital / therapeutic use; Zonisamide / administration & dosage; Zonisamide / pharmacokinetics; Zonisamide / therapeutic use
TL;DR: Considerable variation exists in the pharmacokinetics of LEV‐XR in dogs with epilepsy being treated with a common dose regimen, and drug monitoring may be beneficial to determine the most appropriate dose of levetiracetam in individual dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: November 5, 2018

2018 chapter

Sulfonamides and Potentiated Sulfonamides

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 796–825). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.

By: M. Papich

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: April 5, 2019

2018 chapter

Tetracycline Antibiotics

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed.). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.

By: M. Papich & J. Riviere

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: April 5, 2019

2018 journal article

The pharmacokinetics of cytarabine administered subcutaneously, combined with prednisone, in dogs with meningoencephalomyelitis of unknown etiology

Journal of Veterinary Pharmacology & Therapeutics, 41(5), 638–643.

By: B. Pastina n, P. Early n, R. Bergman*, J. Nettifee n, A. Maller*, K. Bray*, R. Waldron*, A. Castel* ...

Contributors: B. Pastina n, P. Early n, R. Bergman*, J. Nettifee n, A. Maller*, K. Bray*, R. Waldron*, A. Castel* ...

author keywords: canine; cytarabine; MUE; Pharmacokinetics; sparse sampling; subcutaneous; canine; cytarabine; MUE; pharmacokinetics; sparse sampling; subcutaneous
MeSH headings : Animals; Antimetabolites, Antineoplastic / administration & dosage; Antimetabolites, Antineoplastic / blood; Antimetabolites, Antineoplastic / pharmacokinetics; Antimetabolites, Antineoplastic / therapeutic use; Cytarabine / administration & dosage; Cytarabine / blood; Cytarabine / pharmacokinetics; Cytarabine / therapeutic use; Dog Diseases / drug therapy; Dogs; Drug Combinations; Encephalomyelitis / drug therapy; Encephalomyelitis / veterinary; Female; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / blood; Immunosuppressive Agents / pharmacokinetics; Immunosuppressive Agents / therapeutic use; Injections, Subcutaneous; Male; Meningoencephalitis / drug therapy; Meningoencephalitis / veterinary; Prednisone / administration & dosage; Prednisone / blood; Prednisone / pharmacokinetics; Prednisone / therapeutic use
TL;DR: The pharmacokinetics of CA in dogs with MUE after a single 50 mg/m2 SC injection in dogs was similar to what has been previously reported in healthy beagles; there was moderate variability in the population estimates in this clinical population of dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 19, 2018

2018 journal article

The pharmacokinetics of gabapentin in cats

JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(6), 1996–2002.

By: D. Adrian n, M. Papich n, R. Baynes n, E. Stafford n & B. Lascelles n

author keywords: compounded; feline; pain; transdermal
MeSH headings : Analgesics / administration & dosage; Analgesics / blood; Analgesics / pharmacokinetics; Animals; Cats / metabolism; Female; Gabapentin / administration & dosage; Gabapentin / blood; Gabapentin / pharmacokinetics; Half-Life; Injections, Intravenous / veterinary; Male
TL;DR: Repeated oral dosing of gabapentin did not alter the drug's pharmacokinetics, making dose adjustments unnecessary with long‐term treatment, and the transdermal route is an inappropriate choice for drug administration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 31, 2018

2018 book

Veterinary Pharmacology and Therapeutics

(10th ed.). Hoboken, New Jersey, USA: Wiley Blackwell. John Wiley & Sons.

Mark Papich

Ed(s): R. Je & P. Mg

Source: NC State University Libraries
Added: March 9, 2019

2018 chapter

Veterinary Pharmacology: An Introduction to the Discipline

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 3–7). Hoboken, New Jersey: Wiley Blackwell, John Wiley & Sons.

By: J. Riviere & M. Papich

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: April 5, 2019

2018 chapter

Veterinary Pharmacy

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 1427–1438). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.

By: G. Davidson & M. Papich

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: April 5, 2019

2018 chapter

β-Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 826–857). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.

By: M. Papich

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: April 5, 2019

2017 chapter

Antibacterial Drug Therapy

In S. J. Ettinger, E. C. Feldman, & E. Côté (Eds.), Textbook of Veterinary Internal Medicine: Disease of the Dog and the Cat (Eighth, pp. 683–687). St. Louis, Missouri: Elsevier.

By: M. Papich

Ed(s): S. Ettinger, E. Feldman & E. Côté

Source: NC State University Libraries
Added: April 13, 2019

2017 chapter

Antifungal and antiviral therapy

In S. J. Ettinger, E. C. Feldman, & E. Côté (Eds.), Textbook of Veterinary Internal Medicine: Disease of the Dog and the Cat (Eighth, pp. 688–692). St. Louis, Missouri: Elsevier.

By: M. Papich

Ed(s): S. Ettinger, E. Feldman & E. Côté

Source: NC State University Libraries
Added: April 5, 2019

2017 journal article

Antimicrobial use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases

Journal of Veterinary Internal Medicine, 31(2), 279–294.

By: M. Lappin*, J. Blondeau, D. Boothe*, E. Breitschwerdt n, L. Guardabassi*, D. Lloyd*, M. Papich n, S. Rankin* ...

author keywords: Bronchitis; Pneumonia; Pyothorax; Rhinitis
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacterial Infections / drug therapy; Bacterial Infections / veterinary; Cat Diseases / drug therapy; Cats; Dog Diseases / drug therapy; Dogs; Respiratory Tract Diseases / drug therapy; Respiratory Tract Diseases / veterinary
TL;DR: The International Society for Companion Animal Infectious Diseases convened a Working Group of clinical microbiologists, pharmacologists, and internists to share experiences, examine scientific data, review clinical trials, and develop these guidelines to assist veterinarians in making antimicrobial treatment choices. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

CEFOVECIN PHARMACOKINETICS IN THE RED-EARED SLIDER

JOURNAL OF EXOTIC PET MEDICINE, 26(2), 108–113.

By: L. Sypniewski*, L. Maxwell*, J. Murray*, J. Brandao* & M. Papich n

author keywords: chelonian; reptile; antibiotic; cephalosporin; protein binding
TL;DR: Although well tolerated in red‐eared sliders, the rapid decline in plasma cefovecin concentration negates its use as a long‐acting antibiotic in this species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Cephalexin susceptibility breakpoint for veterinary isolates: Clinical Laboratory Standards Institute revision

Journal of Veterinary Diagnostic Investigation, 30(1), 113–120.

By: M. Papich n & C. Lindeman n

author keywords: Breakpoints; cephalexin; cephalothin; CLSI; Staphylococcus pseudintermedius; susceptibility testing
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Cats / microbiology; Cephalexin / pharmacology; Dogs / microbiology; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Staphylococcus / drug effects
TL;DR: Cephalothin should not be used for susceptibility testing of cephalexin for veterinary bacterial pathogens, and canine-specific breakpoints should be used by CLSI for testing susceptibility. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: February 27, 2019

2017 journal article

Chronic maladaptive pain in cats: A review of current and future drug treatment options

The Veterinary Journal, 230, 52–61.

By: D. Adrian n, M. Papich n, R. Baynes n, J. Murrell* & B. Lascelles n

author keywords: Maladaptive pain; Cats; Analgesia; Central plasticity; Chronic pain
MeSH headings : Analgesics / therapeutic use; Animals; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cats; Chronic Pain / diagnosis; Chronic Pain / drug therapy; Chronic Pain / veterinary; Forecasting; Pain Management / trends; Pain Management / veterinary; Pain Measurement / veterinary
TL;DR: The current understanding of chronic or maladaptive pain, techniques for the detection and measurement of the condition and the associated central nervous changes, as well as an overview of the data evaluating potential therapeutics in cats are detailed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 11, 2019

2017 journal article

Ciprofloxacin Pharmacokinetics in Clinical Canine Patients

Journal of Veterinary Internal Medicine, 31(5), 1508–1513.

By: M. Papich n

author keywords: Antibiotic; Canine; Fluoroquinolone; Nonlinear mixed-effects modeling
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Bacterial Infections / drug therapy; Bacterial Infections / veterinary; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Dog Diseases / drug therapy; Dog Diseases / microbiology; Dogs; Female; Half-Life; Male; Microbial Sensitivity Tests / veterinary; Monte Carlo Method; Prospective Studies
TL;DR: The size of the dog was an important covariate with larger dogs achieving lower plasma drug concentrations than smaller dogs, despite a similar mg/kg dose, which is much lower than the breakpoint of ≤1 μg/mL in humans. (via Semantic Scholar)
Source: ORCID
Added: February 11, 2019

2017 journal article

Comparison of direct sampling and brochoalveolar lavage for determining active drug concentrations in the pulmonary epithelial lining fluid of calves injected with enrofloxacin or tilmicosin

Journal of Veterinary Pharmacology and Therapeutics, 40(6), e45–e53.

By: D. Foster n, H. Sylvester n & M. Papich n

author keywords: antibiotic; bovine; lung
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / pharmacokinetics; Bronchoalveolar Lavage Fluid / chemistry; Cattle / metabolism; Enrofloxacin; Extracellular Fluid / chemistry; Fluoroquinolones / administration & dosage; Fluoroquinolones / analysis; Fluoroquinolones / pharmacokinetics; Injections, Subcutaneous / veterinary; Lung / chemistry; Male; Respiratory Mucosa / chemistry; Tylosin / administration & dosage; Tylosin / analogs & derivatives; Tylosin / analysis; Tylosin / pharmacokinetics
TL;DR: Concentrations of enrofloxacin/ciprofl oxacin exceeded the MIC values for bovine respiratory disease pathogens but tilmicosin did not reach MIC levels for these pathogens in any fluids. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, ORCID, Web Of Science
Added: February 27, 2019

2017 journal article

Considerations for using minocycline vs doxycycline for treatment of canine heartworm disease

Parasites & Vectors, 10(S2).

By: M. Papich n

author keywords: Minocycline; Doxycycline; Wolbachia; Heartworm; Pharmacokinetics; Pharmacodynamics; Monte Carlo simulation
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Dirofilaria immitis / microbiology; Dirofilaria immitis / physiology; Dirofilariasis / drug therapy; Dirofilariasis / parasitology; Dog Diseases / drug therapy; Dog Diseases / parasitology; Dogs; Doxycycline / administration & dosage; Doxycycline / pharmacokinetics; Mice; Minocycline / administration & dosage; Minocycline / pharmacokinetics; Wolbachia / drug effects; Wolbachia / physiology
TL;DR: Minocycline is an attractive option because of the higher cost of doxycycline and new pharmacokinetic information for dogs that provides guidance for appropriate dosage regimens to achieve pharmacokinetics-pharmacodynamic (PK-PD) targets, but more work is needed to document efficacy of minocyCline for treating canine heartworm disease. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2017 journal article

Furosemide continuous rate infusion diluted with 5% dextrose in water or hypertonic saline in normal adult dogs: a pilot study

JOURNAL OF VETERINARY CARDIOLOGY, 19(1), 44–56.

By: D. Adin n, C. Atkins n, M. Papich n, T. DeFrancesco n, E. Griffiths n, M. Penteado*, K. Kurtz n, A. Klein n

author keywords: Lasix; Diuretic; Sodium; Salt
MeSH headings : Animals; Cross-Over Studies; Diuretics / administration & dosage; Diuretics / adverse effects; Diuretics / pharmacokinetics; Dogs; Furosemide / administration & dosage; Furosemide / adverse effects; Furosemide / pharmacokinetics; Glucose / administration & dosage; Infusions, Intravenous / veterinary; Male; Pilot Projects; Saline Solution, Hypertonic / administration & dosage; Single-Blind Method; Water
TL;DR: Diuresis was similar for both furosemide CRI methods; however, the H-SAL method induced less renin-angiotensin-aldosterone system activation than the DEX method, suggesting that dilution of a furo Semine CRI with 2.4% hypertonic saline may be well tolerated in heart failure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Ketoprofen pharmacokinetics of R - and S -isomers in juvenile loggerhead sea turtles (Caretta caretta ) after single intravenous and single- and multidose intramuscular administration

Journal of Veterinary Pharmacology and Therapeutics, 41(2), 340–348.

By: K. Thompson*, M. Papich n, B. Higgins*, J. Flanagan, E. Christiansen* & C. Harms n

author keywords: Caretta caretta; ketoprofen; loggerhead; nonsteroidal anti-inflammatory; pharmacokinetics
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Drug Administration Schedule / veterinary; Female; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Ketoprofen / administration & dosage; Ketoprofen / pharmacokinetics; Turtles / metabolism
TL;DR: The S-isomer is the predominant isomer in loggerhead sea turtles, similar to most mammals, despite administration of a 50:50 racemic mixture, and a dose of 2 mg/kg either IM or IV every 24 hr is likely appropriate for loggerhead turtles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

New interpretive criteria for danofloxacin antibacterial susceptibility testing against Mannheimia haemolytica and Pasteurella multocida associated with bovine respiratory disease

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 29(2), 224–227.

By: M. Sweeney n, M. Papich n & J. Watts n

author keywords: Clinical and Laboratory Standards Institute; clinical breakpoint; danofloxacin; interpretive criteria; Mannheimia; Pasteurella
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bovine Respiratory Disease Complex / drug therapy; Bovine Respiratory Disease Complex / epidemiology; Bovine Respiratory Disease Complex / microbiology; Cattle; Fluoroquinolones / pharmacology; Mannheimia haemolytica / drug effects; Microbial Sensitivity Tests / veterinary; North America / epidemiology; Pasteurella multocida / drug effects
TL;DR: These newly established intermediate and resistant clinical breakpoint values have been endorsed by CLSI and can be used for interpreting results from antibacterial susceptibility testing of danofloxacin against M. haemolytica and P. multocida isolated from bovine respiratory disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Pharmacokinetics and Relative Bioavailability of Orally Administered Innovator-Formulated Itraconazole Capsules and Solution in Healthy Dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 31(4), 1163–1169.

By: A. Hasbach*, D. Langlois*, E. Rosser* & M. Papich n

author keywords: Blastomycosis; Histoplasmosis; Mycology; Sporanox (R)
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / pharmacokinetics; Capsules; Cross-Over Studies; Dogs / metabolism; Female; Itraconazole / administration & dosage; Itraconazole / pharmacokinetics; Male; Solutions
TL;DR: Overall drug exposures after capsule and solution administration are not substantially different in dogs, and formulation‐specific dosages do not appear to be necessary. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Pharmacokinetics of ampicillin-sulbactam in serum and synovial fluid samples following regional intravenous perfusion in the distal portion of a hind limb of adult cattle

AMERICAN JOURNAL OF VETERINARY RESEARCH, 78(12), 1372–1379.

By: S. Depenbrock, K. Simpson, A. Niehaus, J. Lakritz & M. Papich*

MeSH headings : Administration, Intravenous / veterinary; Ampicillin / administration & dosage; Ampicillin / pharmacokinetics; Animals; Anti-Bacterial Agents / pharmacokinetics; Cattle; Chromatography, High Pressure Liquid / veterinary; Female; Hindlimb; Perfusion; Sulbactam / administration & dosage; Sulbactam / pharmacokinetics; Synovial Fluid / metabolism
TL;DR: Potentially therapeutic concentrations of ampicillin were achieved in regional serum and SYN samples; SYN concentrations remained at potentially therapeutic values for > 12 hours following RIVP of 1.5 g of amicillin-sulbactam in the hind limb of healthy cows. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Pharmacokinetics of an extended-release formulation of eprinomectin in healthy adult alpacas and its use in alpacas confirmed with mange

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 40(2), 192–199.

By: J. Pollock*, D. Bedenice*, S. Jennings* & M. Papich n

MeSH headings : Animals; Area Under Curve; Camelids, New World / blood; Delayed-Action Preparations; Feces / parasitology; Female; Half-Life; Insecticides / administration & dosage; Insecticides / blood; Insecticides / pharmacology; Insecticides / therapeutic use; Ivermectin / administration & dosage; Ivermectin / analogs & derivatives; Ivermectin / blood; Ivermectin / pharmacokinetics; Ivermectin / therapeutic use; Male; Mite Infestations / drug therapy; Mite Infestations / veterinary; Parasite Egg Count
TL;DR: Alpacas require a higher eprinomectin dose than cattle, to reach comparable plasma concentrations, and skin biopsies showed reduced hyperkeratosis, but increased fibrosis, with 1 of 4 alpacas remaining positive on skin scraping for mange. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Pharmacokinetics of intravenous clindamycin phosphate in captive Bennett's wallabies (Macropus rufogriseus)

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 40(6), 682–686.

By: M. Watson*, M. Papich n & S. Chinnadurai*

author keywords: antibiotic; Bennett's wallaby; clindamycin; macropod; pharmacokinetics
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Clindamycin / administration & dosage; Clindamycin / analogs & derivatives; Clindamycin / blood; Clindamycin / pharmacokinetics; Female; Half-Life; Infusions, Intravenous / veterinary; Macropodidae / metabolism; Male
TL;DR: The pharmacokinetic properties of a single intravenous (IV) dose of clindamycin were determined in six wallabies and no adverse effects were noted after IV administration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Plasma and serum concentrations of cytarabine administered via continuous intravenous infusion to dogs with meningoencephalomyelitis of unknown etiology

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 40(4), 411–414.

By: P. Early n, K. Crook, L. Williams*, E. Davis*, K. Munana n, M. Papich n, K. Messenger n

Contributors: P. Early n, K. Crook, L. Williams*, E. Davis*, K. Muñana n, M. Papich n, K. Messenger n

MeSH headings : Animals; Area Under Curve; Cytarabine / administration & dosage; Cytarabine / pharmacokinetics; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Encephalomyelitis / blood; Encephalomyelitis / drug therapy; Encephalomyelitis / veterinary; Infusions, Intravenous / veterinary
TL;DR: The steady-state achieved with cytarabine CRI produces a consistent and prolonged exposure in plasma and serum, which is likely to produce equilibrium between blood and the central nervous system in dogs with a clinical diagnosis of MUE. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 chapter

Section Advisor: Therapeutic Considerations in Medicine and Disease

In S. J. Ettinger, E. C. Feldman, & E. Côté (Eds.), Textbook of Veterinary Internal Medicine: Disease of the Dog and the Cat (Eighth). St. Louis, Missouri: Elsevier.

By: M. Papich

Ed(s): S. Ettinger, E. Feldman & E. Côté

Source: NC State University Libraries
Added: April 13, 2019

2017 journal article

The effects of clopidogrel and omeprazole on platelet function in normal dogs

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 40(2), 130–139.

By: B. Thames*, J. Lovvorn*, M. Papich n, R. Wills*, T. Archer*, A. Mackin*, J. Thomason*

MeSH headings : Animals; Blood Platelets / drug effects; Blood Platelets / physiology; Clopidogrel; Cross-Over Studies; Dogs / blood; Drug Therapy, Combination; Female; Male; Omeprazole / administration & dosage; Omeprazole / pharmacology; Platelet Aggregation Inhibitors / pharmacology; Platelet Function Tests; Proton Pump Inhibitors / pharmacology; Ticlopidine / administration & dosage; Ticlopidine / analogs & derivatives; Ticlopidine / pharmacology
TL;DR: The concurrent administration of omeprazole and clopidogrel in healthy dogs was associated with an increase in the plasma concentration of an inactive metabolite of clopIDogrel, but does not significantly alter the antiplatelet effects of clopsinogrel. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Alternate-day dosing of itraconazole in healthy adult cats

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 39(1), 27–31.

By: S. Middleton*, A. Kubier, L. Dirikolu*, M. Papich n, M. Mitchell* & S. Rubin*

MeSH headings : Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Cats / blood; Drug Administration Schedule; Half-Life; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics
TL;DR: Overall, a 100 mg every other day oral dosage regimen for itraconazole in cats yielded serum concentrations with minimal fluctuation and with careful monitoring may be considered for treatment of cats with systemic fungal disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Antimicrobial susceptibility testing for feline urinary tract isolates

Journal of Feline Medicine and Surgery, 18(2), 183–184.

By: M. Papich*

TL;DR: The Veterinary Antimicrobial Susceptibility Testing (VAST) subcommittee of the Clinical and Laboratory Standards Institute (CLSI) with regard to the paper by Lund et al,1 ‘Antimicrobial susceptibility in bacterial isolates from Norwegian cats with lower urinary tract disease’ is written. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: March 2, 2019

2016 journal article

Assessment of in vitro release of carboplatin from six carrier media

AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(12), 1381–1386.

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Carboplatin / administration & dosage; Delayed-Action Preparations / administration & dosage; Drug Carriers / administration & dosage; Gelatin; Gels; Hemostatics; Microspheres; Neoplasms / drug therapy; Neoplasms / veterinary; Polymers
TL;DR: The poloxamer copolymer gel and hemostatic gelatin sponge released carboplatin rapidly in vitro, whereas calcium sulfate beads did not. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Carprofen pharmacokinetics in plasma and in control and inflamed canine tissue fluid using in vivo ultrafiltration

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 39(1), 32–39.

By: K. Messenger n, J. Wofford n & M. Papich n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Body Fluids / chemistry; Carbazoles / blood; Carbazoles / metabolism; Carbazoles / pharmacokinetics; Carrageenan / toxicity; Dinoprostone / metabolism; Dog Diseases / blood; Dog Diseases / chemically induced; Dog Diseases / metabolism; Dogs; Half-Life; Inflammation / chemically induced; Inflammation / metabolism; Inflammation / veterinary; Ultrafiltration / veterinary
TL;DR: In vivo ultrafiltration is a reliable method to determine unbound carprofen in ISF, and that disposition of unbound drug into tissue is much higher than predicted from un bound drug concentration in plasma, however, concentrations and pharmacokinetic parameter estimates are not significantly different in inflamed vs. un-inflamed tissues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Comparison of active drug concentrations in the pulmonary epithelial lining fluid and interstitial fluid of calves injected with enrofloxacin, florfenicol, ceftiofur, or tulathromycin

PLoS One, 11(2), e0149100.

By: D. Foster n, L. Martin n & M. Papich n

Ed(s): J. Torrelles

MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Biological Availability; Cattle; Cephalosporins / blood; Cephalosporins / pharmacokinetics; Cross-Over Studies; Disaccharides / blood; Disaccharides / pharmacokinetics; Enrofloxacin; Epithelial Cells / metabolism; Extracellular Fluid / chemistry; Extracellular Fluid / metabolism; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Lung / metabolism; Male; Mannheimia haemolytica / drug effects; Mannheimia haemolytica / growth & development; Microbial Sensitivity Tests; Respiratory Mucosa / metabolism; Thiamphenicol / analogs & derivatives; Thiamphenicol / blood; Thiamphenicol / pharmacokinetics; Veterinary Drugs / blood; Veterinary Drugs / pharmacokinetics
TL;DR: The bronchial concentrations were higher than the plasma or interstitial concentrations, with over 900% penetration to the airways, and the tulathromycin concentrations achieved were lower than the MIC of susceptible bacteria at most time points. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: June 8, 2019

2016 journal article

Correction: Comparison of Active Drug Concentrations in the Pulmonary Epithelial Lining Fluid and Interstitial Fluid of Calves Injected with Enrofloxacin, Florfenicol, Ceftiofur, or Tulathromycin

PLOS ONE, 11(7), e0159219.

By: D. Foster*, L. Martin & M. Papich*

TL;DR: This research presents a novel probabilistic procedure that allows for direct measurement of the response of the immune system to earthquake-triggered landsliding. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: June 8, 2019

2016 chapter

Drug Formulary, Appendix IX

In L. P. Tilley & F. W. K. Smith (Eds.), Blackwells's Five Minute Veterinary Consult: Canine and Feline (6th ed., pp. 1445–1548). Wiley Blackwell.

By: M. Papich

Ed(s): L. Tilley & F. Smith

Source: NC State University Libraries
Added: April 5, 2019

2016 personal communication

How to (properly) determine the beyond-use date and stability of a compounded formulation for pets

Papich, M. G., Brown, S., & Kirk, L. (2016, April).

By: M. Papich n, S. Brown & L. Kirk

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

How to (properly) determine the beyond-use date and stability of a compounded formulation for pets

Journal of Feline Medicine & Surgery, 18(4), 364–365.

By: M. Papich, S. Brown & L. Kirk

Source: NC State University Libraries
Added: April 13, 2019

2016 journal article

POPULATION PHARMACOKINETICS OF ENROFLOXACIN AND ITS METABOLITE CIPROFLOXACIN IN THE GREEN SEA URCHIN (STRONGYLOCENTROTUS DROEBACHIENSIS) FOLLOWING INTRACOELOMIC AND IMMERSION ADMINISTRATION

Journal of Zoo and Wildlife Medicine, 47(1), 175–186.

By: B. Phillips, C. Harms*, G. Lewbart*, L. Lahner, M. Haulena, J. Rosenberg, M. Papich*

author keywords: Ciprofloxacin; echinoderms; enrofloxacin; green sea urchin; pharmacokinetics; Strongylocentrotus droebachiensis
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Ciprofloxacin / administration & dosage; Ciprofloxacin / pharmacokinetics; Drug Administration Routes; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / pharmacokinetics; Strongylocentrotus / metabolism
TL;DR: The concentrations of enrofloxacin achieved far exceeded minimum inhibitory concentrations reported for teleost pathogens, indicating minimal production of this metabolite in the green sea urchin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Pharmacokinetics of detomidine following intravenous or oral-transmucosal administration and sedative effects of the oral-transmucosal treatment in dogs

AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(4), 413–420.

By: K. Messenger*, M. Hopfensperger, H. Knych & M. Papich*

MeSH headings : Administration, Mucosal; Administration, Oral; Animals; Biological Availability; Chromatography, Liquid; Dexmedetomidine / administration & dosage; Dexmedetomidine / blood; Dexmedetomidine / pharmacokinetics; Dogs / metabolism; Female; Gels; Half-Life; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / blood; Hypnotics and Sedatives / pharmacokinetics; Imidazoles / administration & dosage; Imidazoles / blood; Imidazoles / pharmacokinetics; Infusions, Intravenous / veterinary; Male; Mass Spectrometry
TL;DR: Detomidine gel administered by the OTM route provided sedation suitable for a short, minimally invasive procedure in healthy dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Pharmacokinetics of minocycline in domestic cats

JOURNAL OF FELINE MEDICINE AND SURGERY, 18(4), 257–263.

By: B. Tynan*, M. Papich n, M. Kerl* & L. Cohn*

MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Biological Availability; Cat Diseases / drug therapy; Cats; Chromatography, High Pressure Liquid / veterinary; Half-Life; Infusions, Intravenous; Microbial Sensitivity Tests; Minocycline / administration & dosage; Minocycline / pharmacokinetics
TL;DR: The pharmacokinetics of minocycline in domestic cats was determined in order to facilitate dosage decisions and it was found that one 50 mg capsule orally q24h would provide appropriate dosing for most cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Pharmacokinetics of voriconazole after intravenous and oral administration to healthy cats

AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(9), 931–939.

By: P. Vishkautsan, M. Papich*, G. Thompson & J. Sykes

MeSH headings : Administration, Intravenous; Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / pharmacokinetics; Biological Availability; Cats; Chemistry, Pharmaceutical; Cross-Over Studies; Half-Life; Suspensions; Tablets; Voriconazole / administration & dosage; Voriconazole / pharmacokinetics
TL;DR: Voriconazole had excellent oral bioavailability and a long half-life in cats and increased plasma concentrations in the target range but increased, which suggested drug accumulation during long-term administration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Population pharmacokinetics of a single dose of meloxicam after oral and intramuscular administration to captive lesser flamingos (Phoeniconaias minor)

American Journal of Veterinary Research, 77(12), 1311–1317.

By: M. Zordan, M. Papich*, A. Pich, K. Unger & C. Sanchez

MeSH headings : Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Biological Availability; Birds / blood; Birds / metabolism; Female; Half-Life; Injections, Intravenous / veterinary; Male; Meloxicam; Thiazines / administration & dosage; Thiazines / pharmacokinetics; Thiazoles / administration & dosage; Thiazoles / pharmacokinetics
TL;DR: In lesser flamingos, oral administration of meloxicam resulted in higher bioavailability and a longer elimination half-life than did IM administration, but the maximum plasma concentration was low and may be insufficient to provide analgesia in flamingos. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2016 journal article

Population pharmacokinetics of enrofloxacin in purple sea stars (Pisaster ochraceus) following an intracoelomic injection or extended immersion

AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(11), 1266–1275.

By: J. Rosenberg, M. Haulena, B. Phillips, C. Harms*, G. Lewbart*, L. Lahner, M. Papich*

MeSH headings : Animals; Chromatography, High Pressure Liquid; Enrofloxacin; Fluoroquinolones / pharmacokinetics; Half-Life; Injections, Intravenous; Microbial Sensitivity Tests; Starfish / metabolism
TL;DR: Results suggested that the described enrofloxacin administration resulted in water vascular system fluid drug concentrations expected to exceed the minimum inhibitory concentration for many bacterial pathogens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Posaconazole Pharmacokinetics in Healthy Cats after Oral and Intravenous Administration

JOURNAL OF VETERINARY INTERNAL MEDICINE, 30(5), 1703–1707.

By: D. Mawby*, J. Whittemore*, L. Fowler* & M. Papich n

author keywords: Bioavailability; Blastomyces; Fungal infection; Histoplasma
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / pharmacokinetics; Area Under Curve; Cats; Female; Half-Life; Injections, Intravenous; Male; Triazoles / administration & dosage; Triazoles / pharmacokinetics
TL;DR: Despite low PO absorption, these data allow for simulation of PO dosage regimens that could be explored in clinical studies, and two regimens can be considered to maintain targeted trough concentrations of 0.5–0.7 μg/mL as extrapolated from studies in humans. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 book

Saunders Handbook of Veterinary Drugs

(Fourth). St. Louis, Missouri: Elsevier-Saunders.

By: M. Papich

Source: NC State University Libraries
Added: March 9, 2019

2015 journal article

ACVIM Consensus Statement on Therapeutic Antimicrobial Use in Animals and Antimicrobial Resistance

Journal of Veterinary Internal Medicine, 29(2), 487–498.

By: J. Weese*, S. Giguère*, L. Guardabassi*, P. Morley*, M. Papich n, D. Ricciuto*, J. Sykes*

author keywords: Antibiotics; Antimicrobial stewardship; Public health; Therapeutics
MeSH headings : Animal Husbandry / methods; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / therapeutic use; Bacteria / drug effects; Bacterial Infections / drug therapy; Bacterial Infections / veterinary; Drug Resistance, Bacterial; Societies, Scientific / organization & administration; United States; Veterinary Drugs; Veterinary Medicine / organization & administration; Veterinary Medicine / standards
TL;DR: This consensus statement aims to provide guidance on the therapeutic use of antimicrobials in animals, balancing the need for effective therapy with minimizing development of antimicrobial resistance in bacteria from animals and humans. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 27, 2019

2015 journal article

Antimicrobial stewardship in companion animal practice

Journal of the American Veterinary Medical Association, 246(3), 287–288.

By: J. Bender, T. Barlam, R. Glore, N. Gumley, S. Grayzel, C. Hoang, M. Murphy, M. Papich ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Applying Biopharmaceutical Classification System (BCS) Criteria to Predict Oral Absorption of Drugs in Dogs: Challenges and Pitfalls

AAPS JOURNAL, 17(4), 948–964.

By: M. Papich n & M. Martinez*

author keywords: BCS; dogs; canine; permeability; solubility
MeSH headings : Administration, Oral; Animals; Biological Availability; Biological Transport; Computer Simulation; Dogs; Drug Design; Humans; Models, Biological; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / classification; Solubility; Species Specificity
TL;DR: The results of this assessment strongly suggest that the human BCS classification system requires substantial modification before it can be reliably applied to dogs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Determination of thermodynamic solubility of active pharmaceutical ingredients for veterinary species: A new USP general chapter

Stimuli to the Revision Process. United States Pharmacopeia Pharmaceutical Forum, 41(3).

By: M. Apley, G. Crist, V. Fellner, M. Gonzalez, R. Hunter, M. Martinez, J. Messenheimer, S. Modric ...

Source: NC State University Libraries
Added: April 5, 2019

2015 journal article

Effect of Chronic Administration of Phenobarbital, or Bromide, on Pharmacokinetics of Levetiracetam in Dogs with Epilepsy

JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(2), 614–619.

By: K. Munana n, J. Nettifee-Osborne n & M. Papich n

Contributors: K. Muñana n, J. Nettifee-Osborne n & M. Papich n

author keywords: Antiepileptic drug; Canine; Drug disposition; Drug interactions; Seizures
MeSH headings : Animals; Anticonvulsants / administration & dosage; Anticonvulsants / pharmacokinetics; Anticonvulsants / therapeutic use; Area Under Curve; Bromides / administration & dosage; Bromides / therapeutic use; Dog Diseases / blood; Dog Diseases / drug therapy; Dog Diseases / metabolism; Dogs; Epilepsy / blood; Epilepsy / drug therapy; Epilepsy / veterinary; Half-Life; Levetiracetam; Phenobarbital / administration & dosage; Phenobarbital / therapeutic use; Piracetam / administration & dosage; Piracetam / analogs & derivatives; Piracetam / pharmacokinetics; Piracetam / therapeutic use
TL;DR: Significant Dosage increases might be indicated when utilizing LEV as add‐on treatment with phenobarbital in dogs when administered concurrently with conventional AEDs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Effect of feeding on the pharmacokinetics of oral minocycline in healthy research dogs

Veterinary Dermatology, 26(6), 399–405.

By: M. Hnot, L. Cole, G. Lorch, P. Rajala-Schultz & M. Papich

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Evaluation of canine- specific minocycline and doxycycline susceptibility breakpoints for meticillin-resistant Staphylococcus pseudintermedius isolates from dogs

Veterinary Dermatology, 26(5), 334–338.

By: M. Hnot, L. Cole, G. Lorch, M. Papich, P. Rajala-Schultz & J. Daniels

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Evaluation of the Effect of Orally Administered Acid Suppressants on Intragastric pH in Cats

JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(1), 104–112.

By: S. Parkinson*, K. Tolbert*, K. Messenger n, A. Odunayo*, M. Brand*, G. Davidson n, E. Peters*, A. Reed*, M. Papich n

author keywords: Bravo monitoring; Famotidine; Feline; Omeprazole
MeSH headings : Animals; Antacids / administration & dosage; Antacids / pharmacokinetics; Antacids / pharmacology; Anti-Ulcer Agents / administration & dosage; Anti-Ulcer Agents / pharmacology; Area Under Curve; Cats / physiology; Cross-Over Studies; Famotidine / pharmacology; Half-Life; Hydrogen-Ion Concentration; Monitoring, Physiologic / instrumentation; Monitoring, Physiologic / veterinary; Ointments; Omeprazole / administration & dosage; Omeprazole / pharmacokinetics; Omeprazole / pharmacology; Stomach / physiology; Tablets
TL;DR: Fractionated enteric‐coated OT is an effective acid suppressant despite disruption of the enteric coating and both omeprazole formulations provide superior acid suppression in cats compared to famotidine or placebo. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 chapter

Nonsteroidal anti-inflammatory drugs

In K. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), Lumb & Jones' Veterinary Anesthesia and Analgesia (5th ed., pp. 227–243). Wiley Blackwell.

By: M. Papich & K. Messenger

Ed(s): K. Grimm, L. Lamont, W. Tranquilli, S. Greene & S. Robertson

Source: NC State University Libraries
Added: April 5, 2019

2015 journal article

Opinions of clinical veterinarians at a US veterinary teaching hospital regarding antimicrobial use and antimicrobial-resistant infections

Journal of the American Veterinary Medical Association, 247(8), 938–944.

By: M. Jacob*, J. Hoppin*, N. Steers*, J. Davis*, G. Davidson*, B. Hansen, K. Lunn*, K. Murphy, M. Papich*

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacteria / drug effects; Bacterial Infections / microbiology; Bacterial Infections / veterinary; Cross-Sectional Studies; Data Collection; Drug Resistance, Bacterial; Education, Veterinary; Female; Hospitals, Animal; Humans; Male; Professional Practice; Schools, Veterinary; United States; Veterinarians
TL;DR: Findings indicated that veterinarians at this teaching hospital were concerned about antimicrobial resistance, thought antimicrobials were overprescribed, and supported restricting use of certain antimicrobial classes in companion animals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

PHARMACOKINETICS OF SINGLE-DOSE ORALLY ADMINISTERED CIPROFLOXACIN IN CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 46(2), 266–272.

By: L. Barbosa, S. Johnson, M. Papich* & F. Gulland

author keywords: Antibiotic; California sea lion; ciprofloxacin; fluoroquinolone; pharmacokinetic; marine mammal
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Dose-Response Relationship, Drug; Sea Lions / blood
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Pharmacokinetics and distribution of voriconazole in body fluids of dogs after repeated oral dosing

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 38(5), 451–456.

By: J. Lemetayer*, P. Dowling*, S. Taylor* & M. Papich n

MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / analysis; Antifungal Agents / blood; Antifungal Agents / cerebrospinal fluid; Antifungal Agents / pharmacokinetics; Aqueous Humor / chemistry; Chromatography, High Pressure Liquid / veterinary; Dogs; Female; Male; Microbial Sensitivity Tests / veterinary; Synovial Fluid / chemistry; Voriconazole / administration & dosage; Voriconazole / analysis; Voriconazole / blood; Voriconazole / cerebrospinal fluid; Voriconazole / pharmacokinetics
TL;DR: Results of this study suggest that twice daily, administration may be necessary to maintain therapeutic plasma concentrations in dogs but further studies are warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Pharmacokinetics of a low dose and FDA-labeled dose of diclazuril administered orally as a pelleted topdressing in adult horses

Journal of Veterinary Pharmacology and Therapeutics, 38(3), 243–248.

By: L. Hunyadi*, M. Papich n & N. Pusterla*

MeSH headings : Administration, Oral; Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / blood; Antiprotozoal Agents / cerebrospinal fluid; Antiprotozoal Agents / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Drug Administration Schedule / veterinary; Female; Horses / metabolism; Male; Nitriles / administration & dosage; Nitriles / blood; Nitriles / cerebrospinal fluid; Nitriles / pharmacokinetics; Triazines / administration & dosage; Triazines / blood; Triazines / cerebrospinal fluid; Triazines / pharmacokinetics
TL;DR: Results of this study show that diclazuril pellets given at the approved label dose and a lower dose both produce similar plasma drug concentrations at steady-state and attain plasma and CSF concentrations known to inhibit Sarcocystis neurona in cell culture. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2015 journal article

Pharmacokinetics of enrofloxacin and ceftiofur in plasma, interstitial fluid, and gastrointestinal tract of calves after subcutaneous injection, and bactericidal impacts on representative enteric bacteria

Journal of Veterinary Pharmacology and Therapeutics, 39(1), 62–71.

By: D. Foster n, M. Jacob n, C. Warren n & M. Papich n

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Cattle / blood; Cephalosporins / administration & dosage; Cephalosporins / blood; Cephalosporins / metabolism; Cephalosporins / pharmacokinetics; Drug Resistance, Bacterial; Enrofloxacin; Enterococcus faecalis / drug effects; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / metabolism; Fluoroquinolones / pharmacokinetics; Half-Life; Intestines / microbiology; Microbial Sensitivity Tests; Salmonella enterica / drug effects
TL;DR: Enrofloxacin and ceftiofur achieved intestinal concentrations capable of reducing intestinal bacteria, yet the short exposure of ceftIOfur in the intestine may select for resistant organisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: March 2, 2019

2015 journal article

Plasma Drug Concentrations of Orally Administered Rosuvastatin in Hispaniolan Amazon Parrots (Amazona ventralis)

JOURNAL OF AVIAN MEDICINE AND SURGERY, 29(1), 18–24.

By: H. Beaufrere, M. Papich*, J. Brandao, J. Nevarez & T. Tully

author keywords: atherosclerosis; statins; rosuvastatin; avian; Hispaniolan Amazon parrot; Amazona ventralis
MeSH headings : Administration, Oral; Amazona / blood; Animals; Fluorobenzenes / administration & dosage; Fluorobenzenes / blood; Fluorobenzenes / pharmacokinetics; Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage; Hydroxymethylglutaryl-CoA Reductase Inhibitors / blood; Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacokinetics; Pyrimidines / administration & dosage; Pyrimidines / blood; Pyrimidines / pharmacokinetics; Rosuvastatin Calcium; Sulfonamides / administration & dosage; Sulfonamides / blood; Sulfonamides / pharmacokinetics
TL;DR: Results indicate that rosuvastatin does not appear suitable in Amazon parrots as compounded and used at the dose in this study, and pharmacodynamic studies investigating lipid-lowering effects of statins rather than pharmacokinetic studies may be more practical and cost effective in future studies to screen for a statin with more ideal properties. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Plasma concentrations of lidocaine in dogs following lidocaine patch application over an incision compared to intact skin

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 38(6), 575–580.

By: S. Joudrey*, D. Robinson*, M. Kearney*, M. Papich n & A. Da Cunha*

MeSH headings : Anesthetics, Local / administration & dosage; Anesthetics, Local / blood; Anesthetics, Local / pharmacokinetics; Animals; Dogs / blood; Dogs / surgery; Female; Lidocaine / administration & dosage; Lidocaine / blood; Lidocaine / pharmacokinetics; Male; Skin / metabolism; Transdermal Patch
TL;DR: It is demonstrated that the actual body exposure to lidocaine was significantly higher when an incision was present compared to intact skin, and the AUC was significantlyHigher in the Incision Group. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Posaconazole pharmacokinetics after administration of an intravenous solution, oral suspension, and delayed-release tablet to dogs

AMERICAN JOURNAL OF VETERINARY RESEARCH, 76(5), 454–459.

By: J. Kendall n & M. Papich*

MeSH headings : Administration, Intravenous / veterinary; Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / pharmacokinetics; Biological Availability; Chromatography, High Pressure Liquid / veterinary; Cross-Over Studies; Delayed-Action Preparations / administration & dosage; Delayed-Action Preparations / pharmacokinetics; Dogs / metabolism; Female; Half-Life; Male; Suspensions / administration & dosage; Suspensions / pharmacokinetics; Tablets / administration & dosage; Tablets / pharmacokinetics; Triazoles / administration & dosage; Triazoles / pharmacokinetics
TL;DR: Absorption of the delayed-release tablets was greater than absorption of the oral suspension, with a longer t1/2 that may favor its clinical use in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 chapter

Strategies for Treating Infections in Critically Ill Patients

In Small Animal Critical Care Medicine (pp. 949–955).

By: M. Papich*

Sources: Crossref, NC State University Libraries
Added: February 27, 2019

2015 journal article

The AVMA Task Force for Antimicrobial Stewardship in Companion Animal Practice responds

Journal of the American Veterinary Medical Association, 246(7), 727–728.

By: J. Bender, T. Barlam, R. Glore, N. Gumley, S. Grayzel, C. Hoang, M. Murphy, M. Papich ...

Source: NC State University Libraries
Added: April 17, 2019

2015 personal communication

The AVMA task force for antimicrobial stewardship in companion animal practice responds

By: J. Bender, T. Barlam, R. Glore, N. Gumley, S. Grayzel, C. Hoang, M. Murphy, M. Papich ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Understanding companion animal practitioners' attitudes toward antimicrobial stewardship

Journal of the American Veterinary Medical Association, 247(8), 883–884.

By: S. Grayzel, J. Bender, R. Glore, N. Gumley, J. Sykes, J. Whichard, M. Papich, J. Watts ...

Source: NC State University Libraries
Added: August 6, 2018

2014 chapter

Antibacterial Drugs

In Canine and Feline Infectious Diseases (pp. 66–86).

By: J. Sykes & M. Papich*

Sources: Crossref, NC State University Libraries
Added: February 27, 2019

2014 chapter

Antifungal Drugs

In Canine and Feline Infectious Diseases (pp. 87–96).

By: J. Sykes & M. Papich*

Sources: Crossref, NC State University Libraries
Added: February 27, 2019

2014 chapter

Antiprotozoal Drugs

In Canine and Feline Infectious Diseases (pp. 97–104).

By: J. Sykes & M. Papich*

Sources: Crossref, NC State University Libraries
Added: February 27, 2019

2014 chapter

Antiviral and Immunomodulatory Drugs

In Canine and Feline Infectious Diseases (pp. 54–65).

By: J. Sykes & M. Papich*

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 27, 2019

2014 journal article

Bioequivalence of Orally Administered Generic, Compounded, and Innovator-Formulated Itraconazole in Healthy Dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(1), 72–77.

By: D. Mawby*, J. Whittemore*, S. Genger* & M. Papich n

author keywords: Bioavailability; Blastomyces; Fungal infection; Histoplasma; Pneumonia
MeSH headings : Animals; Area Under Curve; Cross-Over Studies; Dogs / metabolism; Drug Compounding / veterinary; Drugs, Generic / administration & dosage; Drugs, Generic / analysis; Drugs, Generic / pharmacokinetics; Half-Life; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics; Random Allocation; Therapeutic Equivalency
TL;DR: Neither generic nor compounded itraconazole is bioequivalent to the reference formulation in dogs, however, pharmacokinetic data for generic formulation were similar enough that therapeutic concentrations could be achieved. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 chapter

Consulting Editor, Appendix I, Table of Common Drugs: Approximate Dosages

In J. D. Bonagura & D. C. Twedt (Eds.), Kirk’s Current Veterinary Therapy XV (pp. 1307–1335). Saunders- Elsevier.

By: M. Papich

Ed(s): J. Bonagura & D. Twedt

Source: NC State University Libraries
Added: April 5, 2019

2014 journal article

Efficacy of enrofloxacin in a mouse model of sepsis

Journal of the American Association for Laboratory Animal Science, 53(4), 381–386.

By: A. Slate, S. Bandyopadhyay, K. Francis, M. Papich, B. Karolewski, E. Hod, K. Prestia

Source: NC State University Libraries
Added: August 6, 2018

2014 review

Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases)

[Review of ]. Veterinary Dermatology, 25(3), 163-.

By: A. Hillier, D. Lloyd, J. Weese, J. Blondeau, D. Boothe, E. Breitschwerdt, L. Guardabassi, M. Papich ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases)

Veterinary Dermatology, 25(3), 163–175.

By: A. Hillier, D. Lloyd, J. Weese, J. Blondeau, D. Boothe, E. Breitschwerdt, L. Guardabassi, M. Papich ...

Source: NC State University Libraries
Added: April 13, 2019

2014 journal article

Implantation of an ultrafiltration device in the ileum and spiral colon of steers to continuously collect intestinal fluid

Research in Veterinary Science, 97(3), 611–615.

By: C. Warren, T. Prange, N. Campbell, M. Gerard, L. Martin, M. Jacob*, G. Smith*, M. Papich*, D. Foster*

author keywords: Bovine; Gastrointestinal fluid; Surgery; Ultrafiltration
MeSH headings : Animals; Body Fluids; Cattle; Colon / surgery; Ileum / surgery; Intestinal Secretions; Specimen Handling / methods; Specimen Handling / veterinary; Ultrafiltration / instrumentation
TL;DR: Use of ultrafiltration probes is a novel, consistent and humane method to repeatedly sample the gastrointestinal contents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, ORCID
Added: March 2, 2019

2014 journal article

Meloxicam pharmacokinetics using nonlinear mixed-effects modeling in ferrets after single subcutaneous administration

Journal of Veterinary Pharmacology and Therapeutics, 37(4), 382–387.

By: S. Chinnadurai n, K. Messenger n, M. Papich n & C. Harms n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Female; Ferrets / blood; Ferrets / metabolism; Half-Life; Injections, Subcutaneous; Male; Meloxicam; Sex Factors; Thiazines / administration & dosage; Thiazines / pharmacokinetics; Thiazoles / administration & dosage; Thiazoles / pharmacokinetics
TL;DR: Sex differences in the pharmacokinetic behavior of meloxicam should be taken into consideration when treating ferrets, as these animals are considered effective in other species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Minocycline pharmacokinetics and pharmacodynamics in dogs: dosage recommendations for treatment of meticillin-resistant Staphylococcus pseudintermedius infections

Veterinary Dermatology, 25(3), 182–e47.

By: M. Maaland*, L. Guardabassi* & M. Papich n

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / pharmacology; Area Under Curve; Cross-Over Studies; Dog Diseases / drug therapy; Dog Diseases / microbiology; Dogs; Dose-Response Relationship, Drug; Half-Life; Methicillin Resistance; Minocycline / administration & dosage; Minocycline / blood; Minocycline / pharmacokinetics; Minocycline / pharmacology; Staphylococcal Skin Infections / drug therapy; Staphylococcal Skin Infections / veterinary; Staphylococcus / drug effects; Tissue Distribution
TL;DR: This study provides dosage recommendations for therapy of meticillin-resistant Staphylococcus pseudintermedius infections in dogs and provides PK/PD data necessary to consider species-specific clinical breakpoints for minocycline susceptibility testing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2014 journal article

PHARMACOKINETICS OF SINGLE DOSE ORAL MELOXICAM IN BOTTLENOSE DOLPHINS (TURSIOPS TRUNCATUS)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 45(3), 594–599.

By: C. Simeone, H. Nollens, J. Meegan, T. Schmitt, E. Jensen, M. Papich*, C. Smith

author keywords: Bottlenose dolphin; pharmacokinetics; meloxicam; Tursiops truncatus
MeSH headings : Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Bottle-Nosed Dolphin / blood; Female; Male; Meloxicam; Thiazines / administration & dosage; Thiazines / blood; Thiazines / pharmacokinetics; Thiazoles / administration & dosage; Thiazoles / blood; Thiazoles / pharmacokinetics
TL;DR: The elimination of meloxicam in cetaceans was slower than in other species, with an elimination half-life of almost 70 hr, and detectable drug concentrations up to 7 days, suggesting that a single oral dose of 0.1 mg/kg appears safe for use in this species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Pharmacokinetic-pharmacodynamic (PK-PD) modeling and the rational selection of dosage regimes for the prudent use of antimicrobial drugs

Papich, M. G. (2014, July 16). VETERINARY MICROBIOLOGY, Vol. 171, pp. 480–486.

By: M. Papich n

author keywords: Antimicrobial; Antibiotic; Pharmacokinetic; Pharmacodynamic; Monte Carlo simulation; Resistance
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Cephalosporins / administration & dosage; Cephalosporins / pharmacokinetics; Drug Dosage Calculations; Drug Resistance, Microbial; Inappropriate Prescribing / prevention & control; Inappropriate Prescribing / veterinary; Microbial Sensitivity Tests; Models, Biological; Monte Carlo Method; Time Factors; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: It is the goal of the CLSI subcommittee that these revised breakpoints will encourage more effective antimicrobial use and avoid unnecessary antimicrobial administration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Pharmacokinetic-pharmacodynamic values for amoxicillin in pigs

American Journal of Veterinary Research, 75(4), 316.

By: M. Papich

MeSH headings : Amoxicillin / pharmacology; Animals; Anti-Bacterial Agents / pharmacology; Bacterial Infections / veterinary; Monte Carlo Method; Swine / blood; Swine Diseases / drug therapy
Sources: NC State University Libraries, NC State University Libraries
Added: April 14, 2019

2014 journal article

Pharmacokinetics and preliminary safety data of a single oral dose of bosentan, a dual endothelin receptor antagonist, in cats

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 37(2), 192–195.

By: N. Puza*, M. Papich n, C. Reinero*, C. Chang*, D. Yu*, C. Sharp*, A. DeClue*

MeSH headings : Administration, Oral; Animals; Antihypertensive Agents / administration & dosage; Antihypertensive Agents / adverse effects; Antihypertensive Agents / pharmacokinetics; Bosentan; Cats / blood; Half-Life; Male; Statistics as Topic; Sulfonamides / administration & dosage; Sulfonamides / adverse effects; Sulfonamides / pharmacokinetics
TL;DR: Further evaluation of repeat dosing, investigation into the in vivo efficacy of decreasing endothelin-1 concentrations in cats, as well as safety in conjunction with other medications is warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Plasma and synovial fluid concentration of doxycycline following low-dose, low-frequency administration, and resultant inhibition of matrix metalloproteinase-13 from interleukin-stimulated equine synoviocytes

EQUINE VETERINARY JOURNAL, 46(2), 198–202.

By: M. Maher*, L. Schnabel*, J. Cross*, M. Papich n, T. Divers* & L. Fortier*

author keywords: synovial fluid; osteoarthritis; doxycycline; horse; MMP
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Cells, Cultured; Cross-Over Studies; Dose-Response Relationship, Drug; Doxycycline / administration & dosage; Doxycycline / blood; Doxycycline / chemistry; Doxycycline / pharmacokinetics; Drug Administration Schedule; Gene Expression Regulation, Enzymologic / drug effects; Horses; Matrix Metalloproteinase 13 / genetics; Matrix Metalloproteinase 13 / metabolism; Matrix Metalloproteinase Inhibitors / administration & dosage; Matrix Metalloproteinase Inhibitors / blood; Matrix Metalloproteinase Inhibitors / chemistry; Matrix Metalloproteinase Inhibitors / pharmacokinetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Synovial Fluid / chemistry; Synovial Membrane / cytology
TL;DR: This study supports the use of doxycycline as a disease modifying osteoarthritic drug and achieves SF concentrations in vivo capable of diminishing MMP-13 expression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 chapter

Principles of Antiinfective Therapy

In Canine and Feline Infectious Diseases (pp. 46–53).

By: J. Sykes & M. Papich n

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 27, 2019

2014 chapter

Respiratory drug therapy

In J. D. Bonagura & D. C. Twedt (Eds.), Kirk’s Current Veterinary Therapy XV (pp. 622–628). Saunders-Elsevier.

By: E. Hawkins & M. Papich

Ed(s): J. Bonagura & D. Twedt

Source: NC State University Libraries
Added: April 5, 2019

2014 journal article

Response to letter from J Mottet “Comments on the ISCAID Guidelines on the use of antimicrobial therapies in canine superficial bacterial folliculitis”

Response to letter from J Mottet “Comments on the ISCAID Guidelines on the use of antimicrobial therapies in canine superficial bacterial folliculitis.” Veterinary Dermatology, 25(6), 567–568.

By: D. Lloyd*, J. Weese*, J. Blondeau*, D. Boothe*, E. Breitschwerdt n, L. Guardabassi*, M. Papich n, S. Rankin* ...

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Dog Diseases / diagnosis; Folliculitis / veterinary; Skin Diseases, Bacterial / veterinary
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2014 journal article

Workshop report: The 2012 Antimicrobial Agents in Veterinary Medicine: exploring the consequences of antimicrobial drug use: a 3-D approach

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 37(1), E1–E16.

By: M. Martinez*, J. Blondeau*, C. Cerniglia*, J. Fink-Gremmels*, S. Guenther*, R. Hunter*, X. Li*, M. Papich n ...

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacterial Infections / drug therapy; Bacterial Infections / microbiology; Bacterial Infections / veterinary; Drug Resistance, Bacterial; Drug Utilization / standards; Humans; Veterinary Medicine / standards
TL;DR: This report aims to provide a summary of the presentations and discussions occurring during the 2012 AAVM with the goal of stimulating future discussions and enhancing the opportunity to establish creative and sustainable solutions that will guarantee the availability of an effective therapeutic arsenal for veterinary species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Antibiotic Treatment of Resistant Infections in Small Animals

Veterinary Clinics of North America: Small Animal Practice, 43(5), 1091–1107.

By: M. Papich n

author keywords: Antibiotics; Resistance; Infection; Small animals
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Bacterial Infections / drug therapy; Bacterial Infections / microbiology; Bacterial Infections / veterinary; Cat Diseases / drug therapy; Cat Diseases / microbiology; Cats; Dog Diseases / drug therapy; Dog Diseases / microbiology; Dogs; Drug Resistance, Bacterial
TL;DR: There are few veterinary clinical studies to support a recommended use and dose for treating resistant bacterial infections in small animals and a susceptibility test is needed to identify the appropriate drug for these infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2013 chapter

Antimicrobial drugs

In R. J. Washabau & M. J. Day (Eds.), Canine and Feline Gastroenterology (pp. 471–476). St. Louis, Missouri: Elsevier Saunders.

By: M. Papich

Ed(s): R. Washabau & M. Day

Source: NC State University Libraries
Added: April 5, 2019

2013 journal article

Antimicrobials, Susceptibility Testing, and Minimum Inhibitory Concentrations (MIC) in Veterinary Infection Treatment

Veterinary Clinics of North America: Small Animal Practice, 43(5), 1079–1089.

By: M. Papich n

author keywords: Antimicrobials; Minimum inhibitory concentration; Susceptibility testing; Veterinary infection treatment
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Bacteria / drug effects; Bacterial Infections / drug therapy; Bacterial Infections / microbiology; Bacterial Infections / veterinary; Bacteriological Techniques; Dogs; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Veterinary Drugs
TL;DR: There are many reasons why antimicrobial treatment fails and when evaluating a patient that has failed to respond to therapy, one must consider any of the many factors that contribute to antibiotic failure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2013 journal article

Assessment of Plasma Concentrations and Potential Adverse Effects of Doxycycline in Cockatiels (Nymphicus hollandicus) Fed a Medicated Pelleted Diet

JOURNAL OF AVIAN MEDICINE AND SURGERY, 27(3), 187–193.

By: K. Flammer n, J. Massey n, T. Roudybush, C. Meek n & M. Papich n

author keywords: Chlamydophila psittaci; spiral bacteria; antimicrobial drug; doxycycline; pharmacology; avian; cockatiel; Nymphicus hollandicus
MeSH headings : Animal Feed / analysis; Animals; Anti-Bacterial Agents / adverse effects; Anti-Bacterial Agents / blood; Cockatoos / blood; Doxycycline / adverse effects; Doxycycline / blood; Food Handling; Time Factors
TL;DR: This medicated diet may be suitable for treating spiral bacteria and Chlamydophila psittaci infections in cockatiels that will consume a pelleted diet. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Doxycycline concentration over time after storage in a compounded veterinary preparation

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 242(12), 1674–1678.

By: M. Papich n, G. Davidson & L. Fortier

MeSH headings : Anti-Bacterial Agents / chemistry; Chemistry, Pharmaceutical; Doxycycline / chemistry; Drug Compounding; Drug Stability; Drug Storage; Suspensions; Time Factors; Veterinary Drugs / chemistry
TL;DR: The concentration of doxycycline compounded from commercial tablets in the vehicles evaluated to yield doses of 33.3 and 166.7 mg/mL cannot be assured beyond 7 days, and the quality of the formulations decreased as well. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 chapter

Drug therapy for diseases of the central nervous system

In S. R. Platt & N. J. Olby (Eds.), BSAVA Manual of Canine and Feline Neurology (4th ed., pp. 452–469). Gloucester: British Small Animal Veterinary Association.

By: M. Papich

Ed(s): S. Platt & N. Olby

Source: NC State University Libraries
Added: April 13, 2019

2013 journal article

Elution of antimicrobials from a cross-linked dextran gel: In vivo Quantification

EQUINE VETERINARY JOURNAL, 45(2), 148–153.

By: S. Hart, J. Barrett*, J. Brown*, M. Papich n, B. Powers* & K. Sullins*

author keywords: horse; antibiotic delivery device; local antimicrobial; elution; biodegradable
MeSH headings : Amikacin / administration & dosage; Amikacin / blood; Amikacin / pharmacokinetics; Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Clindamycin / administration & dosage; Clindamycin / blood; Clindamycin / pharmacokinetics; Delayed-Action Preparations; Dextrans / chemistry; Drug Implants; Horses / blood; Microbial Sensitivity Tests; Vancomycin / administration & dosage; Vancomycin / blood; Vancomycin / pharmacokinetics
TL;DR: Cross-linked dextran gel is a safe, effective alternative local antimicrobial delivery method for treatment and wound healing when implanted subcutaneously in horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Identifying antimicrobial resistance

Journal of the American Veterinary Medical Association, 243(11), 1517–1518.

By: M. Papich

Source: NC State University Libraries
Added: April 13, 2019

2013 journal article

Pharmacodynamics of Doxycycline and Tetracycline against Staphylococcus pseudintermedius: Proposal of Canine-Specific Breakpoints for Doxycycline

JOURNAL OF CLINICAL MICROBIOLOGY, 51(11), 3547–3554.

By: M. Maaland*, M. Papich n, J. Turnidge* & L. Guardabassi*

MeSH headings : Animals; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / pharmacology; Dog Diseases / drug therapy; Dog Diseases / microbiology; Dogs; Doxycycline / pharmacokinetics; Doxycycline / pharmacology; Microbial Sensitivity Tests; Models, Theoretical; Staphylococcal Infections / drug therapy; Staphylococcal Infections / microbiology; Staphylococcal Infections / veterinary; Staphylococcus / drug effects; Tetracycline / pharmacokinetics; Tetracycline / pharmacology
TL;DR: Doxycycline was more active than tetracycline in non-wild-type strains and the two drugs displayed bacteriostatic activity and bimodal MIC distributions, and canine-specific doxycycline MIC breakpoints were proposed based on the data generated in this study. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Ronidazole pharmacokinetics in cats following delivery of a delayed-release guar gum formulation

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(4), 399–407.

By: M. Papich n, D. LeVine n, J. Gookin n, G. Davidson n, W. Stagner* & R. Hayes n

MeSH headings : Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / blood; Antiprotozoal Agents / pharmacokinetics; Area Under Curve; Cats / blood; Cats / metabolism; Delayed-Action Preparations; Galactans / chemistry; Half-Life; Male; Mannans / chemistry; Plant Gums / chemistry; Ronidazole / administration & dosage; Ronidazole / blood; Ronidazole / pharmacokinetics; Tablets
TL;DR: Delayed release of ronidazole from guar gum-coated tablets indicates that release of RDZ may be delayed to deliver the medication to a targeted area of the intestine in cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Stability of three commonly compounded extemporaneous enrofloxacin suspensions for oral administration to exotic animals

Journal of the American Veterinary Medical Association, 243(1), 85–90.

By: O. Petritz n, D. Guzman n, V. Wiebe n & M. Papich n

MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Drug Compounding; Drug Stability; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / chemistry; Pets; Suspensions / chemistry
TL;DR: Results indicated that, when stored in amber-colored vials at room temperature for 56 days, the enrofloxacin concentration strength in all 3 formulations was retained within acceptance criteria of 90% to 110%. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

The pharmacokinetics of cytarabine in dogs when administered via subcutaneous and continuous intravenous infusion routes

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(4), 408–411.

By: K. Crook n, P. Early n, K. Messenger n, K. Munana n, R. Gallagher n & M. Papich n

Contributors: K. Crook n, P. Early n, K. Messenger n, K. Muñana n, R. Gallagher n & M. Papich n

MeSH headings : Animals; Antimetabolites, Antineoplastic / administration & dosage; Antimetabolites, Antineoplastic / blood; Antimetabolites, Antineoplastic / pharmacokinetics; Area Under Curve; Cross-Over Studies; Cytarabine / administration & dosage; Cytarabine / blood; Cytarabine / pharmacokinetics; Dogs / blood; Dogs / metabolism; Half-Life; Infusions, Intravenous / veterinary; Injections, Subcutaneous / veterinary
TL;DR: The steady state achieved with the cyTarabine CRI may produce a more prolonged exposure of cytarabine at cytotoxic levels in plasma compared to the concentrations after SC administration, as these are two routes of administration commonly employed in the treatment of meningitis of unknown etiology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

The pharmacokinetics of midazolam after intravenous, intramuscular, and rectal administration in healthy dogs

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(5), 471–477.

By: M. Schwartz n, K. Munana n, J. Nettifee-Osborne n, K. Messenger n & M. Papich n

Contributors: M. Schwartz n, K. Muñana n, J. Nettifee-Osborne n, K. Messenger n & M. Papich n

MeSH headings : Administration, Rectal; Animals; Anticonvulsants / administration & dosage; Anticonvulsants / blood; Anticonvulsants / pharmacokinetics; Chromatography, High Pressure Liquid; Dogs; Female; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Male; Midazolam / administration & dosage; Midazolam / blood; Midazolam / pharmacokinetics
TL;DR: It is suggested that IM midazolam might be useful in treating seizures in dogs when venous access is unavailable, but higher doses may be needed to account for intermediate bioavailability. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

The use of oral transmucosal detomidine hydrochloride gel to facilitate handling in dogs

JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH, 8(3), 114–123.