Works (476)
Updated: April 4th, 2024 11:30
2024 article
The effects of food on the pharmacokinetics of mycophenolate mofetil in healthy horses
Bello, K., Lorch, G., Papich, M. G., Kim, K., Toribio, R. E., Yan, L., … Phelps, M. A. (2024, February 9). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 2.
author keywords: equine; fed vs. fasted; immune-mediated; mycophenolate mofetil; pharmacokinetics
TL;DR:
Evidence of enterohepatic recirculation was seen only in the fasted state; this did not yield clinical differences in horses administered a single-dose MMF administration but may be significant in horses receiving long-term MMF treatment.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 19, 2024
2023 journal article
Antimicrobial agents in small animal dermatology for treating staphylococcal infections
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 261, S130–S139.
TL;DR:
Concerns are discussed that veterinarians may have to rely on antibiotics that were previously used uncommonly for skin infections, such as chloramphenicol, aminoglycosides, tetracyclines, and human-label antibiotics such as rifampin and linezolid.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: September 11, 2023
2023 article
Effects of storage up to 1 year on the in vitro antimicrobial activity of preformulated antibiotic-impregnated calcium sulfate beads
Hartman, E. A., Hernandez, D. P., Hendrix, G. K., Risselada, M., Weng, H.-Y., Papich, M. G., & Kim, S. Y. (2023, August 13). VETERINARY SURGERY, Vol. 8.
TL;DR:
Light protected storage at room temperature for up to 12 months did not impair the in vitro activity of antibiotic-impregnated CaSO4 beads, as demonstrated through ZOIs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 28, 2023
2023 journal article
Pharmacokinetics of a FDA-labeled dose of diclazuril administered orally once weekly to adult horses
JOURNAL OF EQUINE VETERINARY SCIENCE, 120.
author keywords: Sarcocystis neurona; diclazuril; pharmacokinetic; prevention; horses
MeSH headings : Horses; Animals; Coccidiostats / pharmacology; Coccidiostats / therapeutic use; Seroepidemiologic Studies; Sarcocystis; Nitriles / pharmacology; Nitriles / therapeutic use
TL;DR:
The oral administration of an FDA-labeled dose of diclazuril to healthy horses once a week was able to produce steady-state plasma drug concentrations known to inhibit S. neurona in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: January 23, 2023
2023 article
Pharmacokinetics of pimobendan after oral administration to dogs with myxomatous mitral valve disease
McManamey, A. K., DeFrancesco, T. C., Meurs, K. M., & Papich, M. G. (2023, September 30). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 9.
author keywords: canine; heart failure; valvular heart disease; Vetmedin
TL;DR:
The pharmacokinetic parameters were highly variable among this group of dogs with MMVD, and the variability was not associated with the dog's age, body weight or condition score, stage of heart disease, dose, serum creatinine, or alkaline phosphatase.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 1, 2023
2023 article
Population pharmacokinetic analysis of enrofloxacin and its active metabolite ciprofloxacin after intravenous injection to cats with reduced kidney function
Foster, J. D., Abouraya, M., Papich, M. G., & Muma, N. A. (2023, September 20). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 9.
author keywords: drug prescribing; feline; fluroquinolone; renal failure
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 10, 2023
2023 journal article
Population pharmacokinetics of single dose oral pimobendan in the ferret (Mustela putorius furo)
JOURNAL OF EXOTIC PET MEDICINE, 48, 1–5.
author keywords: Ferret; Pimobendan; Pharmacokinetic; Mustela putorius furo; O-desmethylpimobendan; Heart failure
Sources: Web Of Science, ORCID
Added: January 29, 2024
2023 journal article
Revision of fluoroquinolone breakpoints used for interpretation of antimicrobial susceptibility testing of canine bacterial isolates
AMERICAN JOURNAL OF VETERINARY RESEARCH, 84(11).
author keywords: antibiotic; enrofloxacin; marbofloxacin; dogs; susceptibility testing
TL;DR:
The Clinical and Laboratory Standards Institute (CLSI) Veterinary Antimicrobial Susceptibility Testing Subcommittee (VAST) revised its antimicrobial susceptibility testing breakpoints and will likely reduce the unnecessary use of these fluoroquinolones in dogs.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: January 2, 2024
2023 journal article
THE PHARMACOKINETICS AND PHARMACODYNAMICS OF ORAL PONAZURIL IN THE TREATMENT OF SYSTEMIC ISOSPOROSIS IN PASSERINE BIRDS
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 54(3), 561–572.
TL;DR:
Results support that treatment of breeding birds with 100 mg/kg ponazuril could reduce the shedding of active oocysts and decrease risk of clinical infection in susceptible juveniles.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: November 13, 2023
2022 article
Ceftazidime pharmacokinetics in dogs after intravenous injection and delivered with the RxActuator Mini-Infuser infusion pump
Papich, M. G., Madsen, M., Messenger, K., & Enomoto, H. (2022, May 6). JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, Vol. 5.
author keywords: antimicrobial; canine; cephalosporin; half-life; mean inhibitory concentration
MeSH headings : Animals; Ceftazidime / pharmacokinetics; Dogs; Humans; Infusion Pumps / veterinary; Infusions, Intravenous / veterinary; Injections, Intravenous / veterinary
TL;DR:
This study demonstrated the successful application of the RxActuator Mini-Infuser wearable SC constant rate infusion pump for delivering an antimicrobial needed for serious, and sometimes resistant, infections in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: May 7, 2022
2022 journal article
Effects of housing environment on oral absorption of acetaminophen in healthy Beagles
AMERICAN JOURNAL OF VETERINARY RESEARCH, 83(1), 80–85.
MeSH headings : Acetaminophen; Animals; Cross-Over Studies; Dogs; Gastric Emptying; Housing
TL;DR:
It is suggested that in dogs, housing environment (normal environment vs a cage in an unfamiliar environment) did not significantly affect oral absorption and, by extension, gastric emptying of acetaminophen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(OpenAlex)
Sources: Web Of Science, ORCID
Added: February 7, 2022
2022 journal article
Gastrointestinal transit time is faster in Beagle dogs compared to cats
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 260, S8–S14.
MeSH headings : Dogs; Cats; Animals; Gastrointestinal Transit; Cat Diseases; Dog Diseases; Gastrointestinal Tract; Stomach
TL;DR:
GITT is faster in Beagles compared to cats, but gastrointestinal pH are similar when fed the same diet.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: January 17, 2023
2022 article
Impact of gastrointestinal differences in veterinary species on the oral drug solubility, in vivo dissolution, and formulation of veterinary therapeutics
Martinez, M. N., Papich, M. G., & Fahmy, R. (2022, January 1). ADMET AND DMPK, Vol. 1.
author keywords: veterinary; gastrointestinal physiology; formulation considerations; solubility
TL;DR:
These discussions are framed around some of the basic principles associated with drug solubilization, reported species differences in GI fluid composition, types of oral dosage forms typically given for the various animal species, and the effect of prandial state in dogs and cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: January 3, 2022
2022 journal article
PHARMACOKINETICS OF A SINGLE DOSE OF INTRAMUSCULAR AND ORAL MELOXICAM IN YELLOW STINGRAYS (UROBATIS JAMAICENSIS)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 53(1), 153–158.
MeSH headings : Animals; Area Under Curve; Half-Life; Meloxicam; Skates, Fish; Thiazines; Thiazoles
TL;DR:
The recommended meloxicam dosage and frequency for yellow stingrays is 2 mg/kg orally once daily, and due to rapid elimination with the intramuscular administration, maintaining clinically relevant plasma concentrations may be difficult using this route.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: April 8, 2022
2022 journal article
PHARMACOKINETICS OF RECTALLY AND ORALLY ADMINISTERED LEVOFLOXACIN IN ASIAN ELEPHANTS (ELEPHAS MAXIMUS)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 53(4), 670–678.
MeSH headings : Animals; Elephants; Levofloxacin; Area Under Curve; Anti-Bacterial Agents; Anti-Infective Agents
TL;DR:
Based on findings, levofloxacin may be a consideration for administration orally and rectally in Asian elephants and antimicrobial stewardship principles, culture and susceptibility of suspected pathogens, and blood level monitoring should be used to tailor administration of lev ofloxicin in this species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: February 13, 2023
2022 journal article
Update on withdrawal intervals following extralabel use of procaine penicillin G in cattle and swine
Journal of the American Veterinary Medical Association, 260(1), 50–55.
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Cattle; Drug Residues; Penicillin G Procaine / therapeutic use; Swine
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: February 7, 2022
2022 journal article
Veterinary antimicrobial prescribing practices for treatment of presumptive sporadic urinary tract infections in dogs examined at primary care practices in the United States (2010-2019)
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 260, S21–S27.
MeSH headings : Amoxicillin / therapeutic use; Amoxicillin-Potassium Clavulanate Combination / therapeutic use; Animals; Anti-Bacterial Agents / therapeutic use; Dog Diseases / drug therapy; Dogs; Primary Health Care; United States; Urinary Tract Infections / drug therapy; Urinary Tract Infections / epidemiology; Urinary Tract Infections / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: June 13, 2022
2021 journal article
Ampicillin pharmacokinetics in azotemic and healthy dogs
JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(2), 987–992.
author keywords: acute kidney injury; drug concentration; half-life; plasma clearance; volume of distribution
MeSH headings : Administration, Oral; Ampicillin; Animals; Anti-Bacterial Agents; Area Under Curve; Chromatography, High Pressure Liquid / veterinary; Dogs; Half-Life; Prospective Studies
TL;DR:
Increased drug concentrations and slower clearance in azotemic dogs could have clinical importance in contributing to antibiotic associated morbidity requiring indicating the need to adjust ampicillin dosing in dogs with decreased kidney function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: January 21, 2021
2021 journal article
Antimicrobial agent use in small animals what are the prescribing practices, use of PK‐PD principles, and extralabel use in the United States?
Journal of Veterinary Pharmacology and Therapeutics.
author keywords: antibacterial; antibiotics; antiinfective; companion animal; pharmacokinetics
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Anti-Infective Agents / therapeutic use; Cat Diseases / drug therapy; Cats; Dog Diseases / drug therapy; Dogs; Humans; United States; Veterinarians
TL;DR:
There is a need for incentives to approve new agents that will be more appropriate for treating infections in companion animals without increasing the risk of drug-resistant bacteria that could potentially be transferred to humans and the environment and create a public health risk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: October 24, 2020
2021 review
CEFOVECIN PROTEIN BINDING AS A PREDICTOR FOR EXTENDED DURATION OF ACTION: A REVIEW OF CURRENT LITERATURE AND IN VITRO ANALYSIS IN MULTIPLE ZOOLOGICAL SPECIES
[Review of ]. JOURNAL OF ZOO AND WILDLIFE MEDICINE, 52(4), 1185–1194.
MeSH headings : Animals; Anti-Bacterial Agents; Cat Diseases; Cats; Cephalosporins; Dog Diseases; Dogs; Injections, Subcutaneous / veterinary; Protein Binding
TL;DR:
It is suggested that a high percentage of plasma protein binding in vitro may predict in which species cefovecin may exhibit a long half-life and duration of action in vivo, and may aid in selecting species for cef Covecin pharmacokinetic research and for empirical treatment of infections caused by susceptible bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: January 3, 2022
2021 journal article
Cefovecin pharmacokinetics after single-dose intramuscular administration in cheetahs (Acinonyx jubatus)
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 44(5), 829–835.
author keywords: Acinonyx; cefovecin; cephalosporins; pharmacokinetics
MeSH headings : Acinonyx; Animals; Anti-Bacterial Agents; Cephalosporins; Injections, Intramuscular / veterinary
TL;DR:
Results indicate that cefovecin is potentially useful as a long-acting antibiotic in cheetahs, and was highly protein-bound in Cheetah plasma, which is nearly identical to domestic cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: April 19, 2021
2021 journal article
Clinical Outcome of Transcervical Infusion of a Combination of Procaine Penicillin and Gentamicin in Late-term Pregnant Mares
JOURNAL OF EQUINE VETERINARY SCIENCE, 106.
author keywords: Equine; Mare; Pregnant; Penicillin; Gentamicin; Antibiotics
MeSH headings : Animals; Female; Gentamicins; Horses; Penicillin G Procaine; Placenta; Pregnancy; Pregnancy Outcome / veterinary; Uterus
TL;DR:
Two out of nine foals displayed signs of mild neonatal maladjustment syndrome that responded to minimal supportive care and all foals survived to weaning without further complications after transcervical intrauterine infusion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 18, 2021
2021 journal article
Effects of danofloxacin dosing regimen on gastrointestinal pharmacokinetics and fecal microbiome in steers
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Cattle; Enterococcus / drug effects; Escherichia coli / drug effects; Fluoroquinolones / pharmacology; Gastrointestinal Microbiome / drug effects; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / microbiology; Male
TL;DR:
Danofloxacin treatment consistently resulted in the Euryarchaeota phyla decreasing over time, specifically due to a decrease in Methanobrevibacter, and although microbiome differences were minor between dosing groups, the low dose group had a higher number of isolates with MIC values high enough to cause clinically relevant resistance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: July 26, 2021
2021 article
Evaluation of gastrointestinal transit times and pH in healthy cats using a continuous pH monitoring system
Telles, N. J., Simon, B. T., Scallan, E. M., Gould, E. N., Papich, M. G., He, Y., … Tolbert, M. K. (2021, December 8). JOURNAL OF FELINE MEDICINE AND SURGERY, Vol. 12.
author keywords: Motility; residence time; gastric transit; intestinal transit
MeSH headings : Administration, Oral; Animals; Cats; Female; Gastrointestinal Transit; Hydrogen-Ion Concentration; Intestine, Small; Time Factors
TL;DR:
Gastric and intestinal pH differed significantly when the capsule was administered 5’h prior to feeding compared with 1 h after feeding, and transit times for both periods showed high degrees of intra- and inter-individual variability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: December 20, 2021
2021 journal article
Evaluation of urine concentrations of amoxicillin and clavulanate in cats
Journal of Veterinary Internal Medicine.
author keywords: antimicrobial; pharmacokinetic; stewardship; urinary tract infection
MeSH headings : Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents / therapeutic use; Clavulanic Acid; Dogs; Escherichia coli; Microbial Sensitivity Tests / veterinary
TL;DR:
New CLSI uropathogen susceptibility breakpoints for amoxicillin and amoxicillin‐clavulanate in healthy cats are suggested to be increased, increasing the urine breakpoint from ≤0.25 to ≤8 μg/mL.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: December 7, 2020
2021 journal article
Investigation of the Bi-Weekly Administration of Diclazuril on the Antibody Kinetics to Sarcocystis Neurona in Healthy Horses
JOURNAL OF EQUINE VETERINARY SCIENCE, 104.
author keywords: EPM; S; neurona; Diclazuril; Antibody titers; Healthy horses
MeSH headings : Animals; Antibodies; Horse Diseases; Horses; Kinetics; Nitriles; Sarcocystis; Sarcocystosis / veterinary; Seroepidemiologic Studies; Triazines
TL;DR:
The administration of diclazuril pelleted top dress at half the label dose twice weekly was able to maintain low titers to S. neurona in healthy adult horses naturally exposed to the protozoal parasite.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: September 20, 2021
2021 article
Naloxone and nalmefene absorption delivered by hollow microneedles compared to intramuscular injection
Papich, M. G., & Narayan, R. J. (2021, November 24). DRUG DELIVERY AND TRANSLATIONAL RESEARCH, Vol. 11.
author keywords: Microneedle; Opioid; Overdose; Naloxone; Nalmefene
MeSH headings : Analgesics, Opioid; Animals; Cross-Over Studies; Dogs; Humans; Injections, Intramuscular; Naloxone; Naltrexone / analogs & derivatives; Naltrexone / pharmacokinetics; Naltrexone / therapeutic use; Narcotic Antagonists
TL;DR:
These studies were designed to test the feasibility of using the hollow microneedle array as an effective method of naloxone and nalmefene delivery for emergency treatment of opioid-induced respiratory depression (OIRD) in people.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: November 25, 2021
2021 article
Naloxone and nalmefene absorption delivered by hollow microneedles compared to intramuscular injection
Papich, M. G., & Narayan, R. J. (2021, September 30).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: October 1, 2021
2021 journal article
PHARMACOKINETICS OF A SINGLE ORAL DOSE OF PONAZURIL IN THE INDIAN PEAFOWL (PAVO CRISTATUS)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 52(2), 548–554.
MeSH headings : Administration, Oral; Animals; Coccidiostats / blood; Coccidiostats / chemistry; Coccidiostats / pharmacokinetics; Dose-Response Relationship, Drug; Feces / chemistry; Female; Galliformes / metabolism; Male; Triazines / blood; Triazines / chemistry; Triazines / pharmacokinetics
TL;DR:
Ponazuril in peafowl was well absorbed orally, plasma concentrations increased with dose, and elimination was slower than current dosages for birds would suggest.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 12, 2021
2021 journal article
PHARMACOKINETICS OF SUBCUTANEOUS ALPHA LIPOIC ACID, A PROPOSED THERAPEUTIC AID FOR DOMOIC ACID INTOXICATION IN CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 52(3), 872–879.
MeSH headings : Animals; Kainic Acid / analogs & derivatives; Kainic Acid / toxicity; Neurotoxins; Sea Lions; Thioctic Acid
TL;DR:
Therapeutic effects are noted with a CMAX of 4,000 to 5,000 ng/ml in humans; thus in CSLs, 20 mg/kg administered subcutaneously once daily may be sufficient to achieve a therapeutic level in this species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: November 15, 2021
2021 journal article
POPULATION PHARMACOKINETICS OF CEFTAZIDIME AFTER A SINGLE SUBCUTANEOUS INJECTION AND NORMAL ORAL AND CLOACAL BACTERIAL FLORA SURVEY IN EASTERN HELLBENDERS (CRYPTOBRANCHUS ALLEGANIENSIS ALLEGANIENSIS)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 52(1), 90–96.
MeSH headings : Amphibians / blood; Amphibians / metabolism; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Ceftazidime / administration & dosage; Ceftazidime / blood; Ceftazidime / pharmacokinetics; Cloaca / microbiology; Half-Life; Injections, Subcutaneous; Mouth / microbiology; Pilot Projects
TL;DR:
It is indicated that ceftazidime is an appropriate choice of antibiotic in hellbenders and when given at a dosage of 20 mg/kg subcutaneously, maintains concentrations above the MIC of susceptible bacteria for up to 5 days.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: May 24, 2021
2021 journal article
Patterns of antimicrobial drug use in veterinary primary care and specialty practice: A 6-year multi-institution study
JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(3), 1496–1508.
author keywords: antibiotic; antimicrobial drug; antimicrobial prescribing practices; antimicrobial prescription
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Anti-Infective Agents / therapeutic use; Cat Diseases / drug therapy; Cats; Dog Diseases / drug therapy; Dogs; Drug Prescriptions / veterinary; Pharmaceutical Preparations; Primary Health Care; Retrospective Studies
TL;DR:
To quantify companion animal AMD prescribing in primary care and specialty practice across 3 academic veterinary hospitals with particular focus on third‐generation cephalosporins, fluoroquinolones, and carbapenems, a retrospective study is conducted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: May 5, 2021
2021 journal article
Pharmacokinetics of doxycycline in dogs
Journal of Veterinary Pharmacology and Therapeutics.
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents; Dogs; Doxycycline
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: December 25, 2020
2021 journal article
Pharmacokinetics of ketorolac in juvenile loggerhead sea turtles (Caretta caretta) after a single intramuscular injection
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 44(4), 583–589.
author keywords: Caretta caretta; Ketorolac; loggerhead sea turtle; nonlinear mixed effects model; pharmacokinetics
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Injections, Intramuscular / veterinary; Ketorolac; Turtles
TL;DR:
It is concluded that ketorolac may not be an appropriate long-term analgesic for use in loggerhead sea turtles at this dose; however, it may have some benefit as a short- term analgesic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: ORCID, Web Of Science
Added: February 21, 2021
2021 article
Phenylbutazone pharmacokinetics in southern white rhinoceros (Ceratotherium simum simum) after oral administration
Houck, E. L., Papich, M. G., & Delk, K. W. (2021, December 11). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 12.
author keywords: analgesia; Ceratotherium simum; pharmacokinetics; phenylbutazone; rhinoceros
MeSH headings : Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Horses; Perissodactyla; Phenylbutazone
TL;DR:
This study represents the first pharmacokinetic data of phenylbutazone in any rhinoceros species and shows concentrations achieved were similar to what has been reported for horses and were within the half maximal effective concentration for horses for at least 10 h.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: December 12, 2021
2021 journal article
SAFETY OF MULTIPLE-DOSE INTRAMUSCULAR KETOPROFEN TREATMENT IN LOGGERHEAD TURTLES (CARETTA CARETTA)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 52(1), 126–132.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Drug Administration Schedule; Ketoprofen / administration & dosage; Ketoprofen / adverse effects; Ketoprofen / therapeutic use; Thrombelastography; Turtles / blood
TL;DR:
Ketoprofen at 2 mg/kg IM q24hr for up to 5 days in loggerheads appears safe with respect to blood clotting and blood data, although other potential effects were not evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: May 24, 2021
2020 journal article
Capsule endoscopy detects insufficient treatment of gastric bleeding in a dog with chronic hepatitis
VETERINARY RECORD CASE REPORTS, 8(4).
author keywords: omeprazole; canine; rivaroxaban; portal hypertension
TL;DR:
Substantial upper GI bleeding persisted despite excellent gastric acid suppression, bringing into question the value of routinely recommending such therapy in dogs with hepatic failure without additional monitoring for adequacy of treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: November 24, 2020
2020 journal article
Effect of diphenhydramine and cetirizine on immediate and late-phase cutaneous allergic reactions in healthy dogs: a randomized, double-blinded crossover study
VETERINARY DERMATOLOGY, 31(4), 256-+.
MeSH headings : Animals; Cetirizine / therapeutic use; Cross-Over Studies; Diphenhydramine / therapeutic use; Dog Diseases / drug therapy; Dogs; Double-Blind Method; Histamine / administration & dosage; Histamine H1 Antagonists / administration & dosage; Hypersensitivity / drug therapy; Hypersensitivity / veterinary; Male; Skin / drug effects; Skin / pathology; Skin Tests; p-Methoxy-N-methylphenethylamine / administration & dosage
TL;DR:
Oral cetirizine was effective in preventing cutaneous allergic reactions without any obvious adverse effects in dogs and oral DPH failed to show an inhibitory effect despite attaining plasma drug concentrations that are considered effective in people.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: February 27, 2020
2020 journal article
Evaluation of bioabsorbable calcium sulfate hemihydrate beads for local delivery of carboplatin
PLOS ONE, 15(11), e0241718.
Ed(s): S. Clegg
MeSH headings : Absorbable Implants; Animals; Calcium Sulfate / chemistry; Carboplatin / chemistry; Carboplatin / pharmacology; Cats; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Chromatography, High Pressure Liquid; Dogs; Microspheres; Neoplasms / drug therapy; Neoplasms / veterinary; Particle Size; Pilot Projects; Veterinary Medicine
TL;DR:
The novel kit can be used for preparation of carboplatin-impregnated resorbable calcium sulfate beads at variable doses, sizes and formulations and higher peak concentrations, percentages released, and elution rates were observed with the liquid formulation and with highercarboplatin doses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: January 11, 2021
2020 personal communication
Expert Opinion on Verification of Antimicrobial Susceptibility Tests
Patel, J. B., Thomson, R. B., Alby, K., Babady, E., Culbreath, K., Galas, M. F., … Schuetz, A. N. (2020, November).
author keywords: CLIA; antibiotic; antifungal susceptibility testing; antimicrobial; verification
MeSH headings : Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Anti-Infective Agents / pharmacology; Expert Testimony; Humans; Microbial Sensitivity Tests; Pseudomonas Infections / drug therapy
TL;DR:
The Expert Panel on Microbiology would like to respond to the recent commentary by Kirby and colleagues voicing concerns related to verification of commercial antimicrobial susceptibility testing for new drugs that are introduced into the clinical laboratory.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: November 9, 2020
2020 journal article
PHARMACOKINETICS OF A SINGLE DOSE OF FLURALANER ADMINISTERED ORALLY TO AMERICAN BLACK BEARS (URSUS AMERICANUS)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 51(3), 691–695.
MeSH headings : Acaricides / pharmacokinetics; Administration, Oral; Animals; Half-Life; Isoxazoles / pharmacokinetics; Plasma / chemistry; Ursidae / blood
TL;DR:
Administration of a single oral dose of fluralaner may be a viable treatment option for captive and free-ranging black bears affected by mange and it was estimated that the average drug withdrawal time is approximately 64–72 days in this species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: February 8, 2021
2020 journal article
Pharmacokinetics of Ketoprofen in Nile Tilapia (Oreochromis niloticus) and Rainbow Trout (Oncorhynchus mykiss)
FRONTIERS IN VETERINARY SCIENCE, 7.
author keywords: ketoprofen; teleost; tilapia; rainbow trout; pharmacokinctics; non-steroidal anti-inflammatory drugs (NSAIDs); Oncorhynchus mykiss; Oreochromis niloticus
TL;DR:
There were very high plasma concentrations of ketoprofen in trout and tilapia with no adverse effects observed, and future studies on the efficacy, frequency of dosing, analgesia, adverse effects, and route of administration are warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: November 9, 2020
2020 journal article
Plasma concentrations of itraconazole following a single oral dose in juvenile California sea lions (Zalophus californianus)
Journal of Veterinary Pharmacology and Therapeutics.
author keywords: California sea lion; itraconazole; pharmacokinetics; Zalophus californianus
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Female; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics; Male; Sea Lions / blood; Sea Lions / metabolism; Species Specificity
TL;DR:
Data indicate that a single oral dose of itraconazole given as a capsule at 5-10 mg/kg, under the conditions used in this study, does not achieve therapeutic plasma concentrations in California sea lions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: April 15, 2020
2020 journal article
Population pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in clinically diseased or injured Eastern box turtles (Terrapene carolina carolina), yellow‐bellied sliders (Trachemys scripta scripta), and river cooters (Pseudemys concinna)
Journal of Veterinary Pharmacology and Therapeutics.
author keywords: ciprofloxacin; enrofloxacin; population; subcutaneous injection; turtles
MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Ciprofloxacin / blood; Ciprofloxacin / metabolism; Ciprofloxacin / pharmacokinetics; Enrofloxacin / blood; Enrofloxacin / metabolism; Enrofloxacin / pharmacokinetics; Female; Half-Life; Injections, Subcutaneous; Male; Turtles / blood
TL;DR:
Results indicate variable pharmacokinetic parameters for enrofloxacin among turtle species, which will help guide appropriate dosing protocols in injured turtles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: February 13, 2020
2020 journal article
Preliminary Pilot Study of Itraconazole After a Single Oral Dose of a Veterinary Formulation Solution in African Penguins (Spheniscus demersus)
JOURNAL OF AVIAN MEDICINE AND SURGERY, 34(1), 52–56.
author keywords: plasma concentration; itraconazole; avian; African penguin; Spheniscus demersus
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Aspergillosis / drug therapy; Aspergillosis / veterinary; Bird Diseases / drug therapy; Drug Compounding / veterinary; Female; Half-Life; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics; Male; Pilot Projects; Spheniscidae / metabolism
TL;DR:
Encouraging evidence is demonstrated that the FDA-approved formulation of oral itraconazole solution should be considered for future study as a cost-effective treatment for aspergillosis in African penguins and other avian species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: April 20, 2020
2020 journal article
Role of electrolyte concentrations and renin‐angiotensin‐aldosterone activation in the staging of canine heart disease
Journal of Veterinary Internal Medicine.
author keywords: ACVIM; congestive heart failure; diuretic; refractory
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Diuretics / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / metabolism; Dogs; Electrolytes / blood; Heart Diseases / classification; Heart Diseases / drug therapy; Heart Diseases / metabolism; Heart Diseases / veterinary; Kidney Function Tests; Pyridazines / therapeutic use; Renin-Angiotensin System / physiology; Spironolactone / therapeutic use
TL;DR:
Hypochloremia is a useful marker for stage D HD in dogs, and greater RAAS inhibition in stage D versus stage C indicates effectiveness of RAAS‐suppressive treatments in this group of dogs with refractory CHF.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: November 27, 2019
2020 journal article
The effect of combined carprofen and omeprazole administration on gastrointestinal permeability and inflammation in dogs
Journal of Veterinary Internal Medicine.
author keywords: canine; dysbiosis; nonsteroidal anti-inflammatory drug; proton pump inhibitor
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Carbazoles; Dog Diseases / chemically induced; Dog Diseases / drug therapy; Dog Diseases / prevention & control; Dogs; Female; Inflammation / chemically induced; Inflammation / drug therapy; Inflammation / veterinary; Male; Omeprazole / pharmacology; Permeability; Prospective Studies
TL;DR:
Omeprazole prophylaxis induces fecal dysbiosis and increases intestinal inflammatory markers when coadministered with carprofen to otherwise healthy dogs with no other risk factors for GI bleeding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: September 9, 2020
2020 journal article
Use of intravenous lipid therapy in a cat with carprofen overdose
CLINICAL CASE REPORTS, 8(4), 653–657.
author keywords: feline toxicosis; intravenous lipids; NSAID overdose
TL;DR:
It is postulates that ILE can be used for the treatment of carprofen toxicity in cats and supports the lipid sink theory as the main mechanism of action.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID
Added: March 16, 2020
2019 journal article
Antimicrobial Activity of Ceftiofur and Penicillin With Gentamicin Against Escherichia coli and Streptococcus equi Subspecies zooepidemicus in an Ex Vivo Model of Equine Postpartum Uterine Disease
JOURNAL OF EQUINE VETERINARY SCIENCE, 79, 121–126.
author keywords: E. coli; S. zooepidemicus; Postpartum mare; Antibiotic use
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Cephalosporins; Drug Resistance, Bacterial; Escherichia coli; Female; Gentamicins; Horse Diseases / drug therapy; Horses; Humans; Penicillins; Postpartum Period; Streptococcus equi; Uterine Diseases / drug therapy; Uterine Diseases / veterinary
TL;DR:
The intrauterine infusion of procaine penicillin G with gentamicin in cases of postpartum uterine disease caused by E. coli or S. zooepidemicus is supported by the results of this work.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 26, 2019
2019 journal article
Ceftiofur formulation differentially affects the intestinal drug concentration, resistance of fecal Escherichia coli, and the microbiome of steers
PLOS ONE, 14(10).
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacokinetics; Cattle; Cattle Diseases / drug therapy; Cattle Diseases / microbiology; Cephalosporins / administration & dosage; Cephalosporins / chemistry; Cephalosporins / pharmacokinetics; Drug Resistance, Bacterial; Escherichia coli / classification; Escherichia coli / drug effects; Escherichia coli / genetics; Feces / microbiology; Microbial Sensitivity Tests; Microbiota; RNA, Ribosomal, 16S / genetics
TL;DR:
CCFA leads to prolonged, low intestinal drug concentrations, and is associated with decreased E. coli concentration, an increased MIC of ceftiofur in E. Escherichia coli at specific time points, and shifts in the fecal microbiota.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: June 1, 2020
2019 journal article
Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study
VETERINARY DERMATOLOGY, 30(2), 91-+.
MeSH headings : Administration, Intravenous; Administration, Oral; Animals; Cross-Over Studies; Dimenhydrinate / administration & dosage; Dimenhydrinate / blood; Dimenhydrinate / pharmacokinetics; Diphenhydramine / administration & dosage; Diphenhydramine / blood; Diphenhydramine / pharmacokinetics; Dogs; Female; Half-Life; Histamine / adverse effects; Histamine Antagonists / pharmacokinetics; Male; Pilot Projects; Theophylline / blood; Urticaria / chemically induced; Urticaria / drug therapy
TL;DR:
Oral absorption of diphenhydramine was approximately three times greater with a longer half-life when it was administered as the combination product dimenhydrinate, and theophylline reached plasma concentrations considered to be therapeutic for dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: April 2, 2019
2019 journal article
Enrofloxacin Pharmacokinetics and Sampling Techniques in California Sea Hares (Aplysia californica)
Journal of the American Association for Laboratory Animal Science, 58(2), 231–234.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Aplysia / metabolism; Chromatography, High Pressure Liquid; Enrofloxacin / administration & dosage; Enrofloxacin / pharmacokinetics; Laboratory Animal Science
TL;DR:
Hemocoel injection appears to be an effective way to administer enrofloxacin to Aplysia and reach clinically relevant concentrations, and reached therapeutic target concentrations in A. californica when dosed according to the regimen described in the current report.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: April 22, 2019
2019 journal article
Evaluation of Transdermal Administration of Phenobarbital in Healthy Cats
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 55(1), 1–7.
MeSH headings : Administration, Cutaneous; Animals; Cats / blood; Cats / metabolism; Dose-Response Relationship, Drug; Drug Monitoring; Female; Gels; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / adverse effects; Hypnotics and Sedatives / pharmacokinetics; Male; Phenobarbital / administration & dosage; Phenobarbital / adverse effects; Phenobarbital / pharmacokinetics
TL;DR:
Transdermal application of phenobarbital in healthy cats achieves a detectable, but subtherapeutic, serum concentration and appears safe in the short term and the use of therapeutic drug monitoring is recommended to ensure therapeutic serum concentrations are achieved.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: December 31, 2018
2019 journal article
International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats
VETERINARY JOURNAL, 247, 8–25.
author keywords: Antimicrobials; Cystitis; Prostatitis; Pyelonephritis; Antimicrobial stewardship
MeSH headings : Animals; Bacterial Infections / diagnostic imaging; Bacterial Infections / drug therapy; Bacterial Infections / therapy; Bacterial Infections / veterinary; Cat Diseases / diagnosis; Cat Diseases / therapy; Cats; Dog Diseases / diagnosis; Dog Diseases / therapy; Dogs; Pets; Urinary Tract Infections / diagnosis; Urinary Tract Infections / therapy; Urinary Tract Infections / veterinary
TL;DR:
This document is a revision and expansion on the 2011 Antimicrobial Use Guidelines for Treatment of Urinary Tract Disease in Dogs and Cats, providing recommendations for diagnosis and management of sporadic bacterial cystitis, recurrent bacterial cyStitis, pyelonephritis, bacterial prostatitis, and subclinical bacteriuria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: May 20, 2019
2019 journal article
Pharmacokinetics of levofloxacin following oral administration of a generic levofloxacin tablet and intravenous administration to dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 80(10), 957–962.
MeSH headings : Administration, Intravenous; Administration, Oral; Animals; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid / veterinary; Cross-Over Studies; Dogs / metabolism; Female; Half-Life; Levofloxacin / administration & dosage; Levofloxacin / pharmacokinetics; Male; Tablets
TL;DR:
In these dogs, levofloxacin was well absorbed when administered orally, and a dose of approximately 25 mg/kg was sufficient to reach pharmacokinetic-pharmacodynamic targets for treating infections with susceptible Enterobacteriaceae or Pseudomonas aeruginosa.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: April 20, 2020
2019 journal article
Pharmacokinetics of orally administered tramadol in Muscovy ducks (Cairina moschata domestica)
Journal of Veterinary Pharmacology and Therapeutics, 1.
author keywords: analgesia; duck; O-desmethyl-tramadol; tramadol
MeSH headings : Administration, Oral; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Area Under Curve; Ducks / blood; Half-Life; Tramadol / administration & dosage; Tramadol / blood; Tramadol / pharmacokinetics
TL;DR:
This study documents the pharmacokinetics of oral tramadol in Muscovy ducks using a one-compartment model with first-order input to estimate half-life and pharmacokinetic parameters.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: February 27, 2019
2019 journal article
Plasma Bleomycin Concentrations during Electrochemotherapeutic Treatment of Fibropapillomas in Green Turtles Chelonia mydas
JOURNAL OF AQUATIC ANIMAL HEALTH, 31(2), 186–192.
MeSH headings : Animals; Bleomycin / blood; Electrochemotherapy / statistics & numerical data; Electrochemotherapy / veterinary; Papilloma / therapy; Papilloma / veterinary; Plasma / chemistry; Turtles / blood
TL;DR:
This study adds further support that electrochemotherapy with bleomycin has the potential to be used as an effective alternative treatment for this complex disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: July 8, 2019
2019 journal article
Population Pharmacokinetics of Danofloxacin After Single Intramuscular Dose Administration in California Brown Pelicans (Pelecanus occidentalis californicus)
JOURNAL OF AVIAN MEDICINE AND SURGERY, 33(4), 361–368.
author keywords: danofloxacin; pharmacokinetics; avian; brown pelican; Pelecanus occidentalis californicus
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Birds / metabolism; Chromatography, High Pressure Liquid / veterinary; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Half-Life; Injections, Intramuscular / veterinary; Intramuscular Absorption; Microbial Sensitivity Tests / veterinary; Nonlinear Dynamics; Pectoralis Muscles / metabolism
TL;DR:
The intramuscular injection of danofloxacin in pelicans at this dose produced plasma concentrations that meet therapeutic targets for bacteria with a minimum inhibitory concentration of ≤0.25 µg/mL, which can be used for future studies to evaluate the efficacy of dan ofloxicin for treating susceptible bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: December 30, 2019
2019 journal article
Population pharmacokinetics of itraconazole solution after a single oral administration in captive lesser flamingos (Phoeniconaias minor)
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 42(1), 1–6.
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Birds / blood; Birds / metabolism; Female; Half-Life; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics; Male
TL;DR:
It was concluded that plasma drug concentrations of itraconazole were maintained in a population of flamingos above 0.5 ug/ml for at least 24 hr after a single oral dose of 10 mg/kg of it rconazole solution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: January 21, 2019
2019 journal article
Reconciling Human-Canine Differences in Oral Bioavailability: Looking beyond the Biopharmaceutics Classification System
AAPS JOURNAL, 21(5).
author keywords: biopharmaceutics drug disposition classification system; dog oral bioavailability; extended clearance classification system; human oral bioavailability; interspecies extrapolation
MeSH headings : Animals; Biological Availability; Biopharmaceutics / classification; Dogs; Drug Development / methods; Humans; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / metabolism; Solubility; Species Specificity
TL;DR:
It is concluded that although neither the BDDCS nor the ECCS can reliably improve the ability to determine when F will be similar in humans and dogs, the E CCS provides a mechanism to help define possible causes for observed human-canine inconsistencies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 26, 2019
2018 journal article
ACVIM consensus statement: Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats
JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(6), 1803–1822.
author keywords: blood pressure; cardiology; cardiovascular; chronic renal failure; hemodynamics; hypertension; kidney; proteinuria; renal/urinary tract
MeSH headings : Animals; Antihypertensive Agents / therapeutic use; Blood Pressure; Blood Pressure Determination / veterinary; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cat Diseases / etiology; Cats; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / etiology; Dogs; Hypertension / diagnosis; Hypertension / drug therapy; Hypertension / etiology; Hypertension / veterinary; Reference Values
TL;DR:
An update to the 2007 American College of Veterinary Internal Medicine consensus statement on the identification, evaluation, and management of systemic hypertension in dogs and cats was presented at the 2017 ACVIM Forum in National Harbor, MD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: December 31, 2018
2018 journal article
ACVIM consensus statement: Support for rational administration of gastrointestinal protectants to dogs and cats
JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(6), 1823–1840.
author keywords: acid; canine; feline; gastroesophageal reflux; histamine type-2 receptor antagonist; misoprostol; proton pump inhibitor; sucralfate; ulcer
MeSH headings : Animals; Cat Diseases / drug therapy; Cats; Dog Diseases / drug therapy; Dogs; Gastrointestinal Agents / administration & dosage; Gastrointestinal Agents / therapeutic use; Gastrointestinal Diseases / drug therapy; Gastrointestinal Diseases / veterinary; Misoprostol / administration & dosage; Misoprostol / therapeutic use; Proton Pump Inhibitors / administration & dosage; Proton Pump Inhibitors / therapeutic use; Sucralfate / administration & dosage; Sucralfate / therapeutic use
TL;DR:
This report challenges the dogma and clinical practice of administering GI protectants for the routine management of gastritis, pancreatitis, hepatic disease, and renal disease in dogs and cats lacking additional risk factors for ulceration or concerns for GI bleeding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: December 31, 2018
2018 chapter
Anticoagulant, Antiplatelet, and Hemostatic Drugs
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 625–646). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.
Source: NC State University Libraries
Added: April 5, 2019
2018 chapter
Chloramphenicol and Derivatives, Macrolides, Lincosamides, and Miscellaneous Antimicrobials
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed.). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.
Source: NC State University Libraries
Added: April 5, 2019
2018 journal article
Comparison of absorption characteristics of oral reference and compounded itraconazole formulations in healthy cats
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 252(2), 195–200.
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / chemistry; Antifungal Agents / pharmacokinetics; Area Under Curve; Cats / blood; Cross-Over Studies; Dosage Forms; Half-Life; Itraconazole / administration & dosage; Itraconazole / chemistry; Itraconazole / pharmacokinetics; Random Allocation; Therapeutic Equivalency
TL;DR:
Compounded oral formulations of itraconazole should not be used for cats because of poor absorption and the differences in absorption between the 2 reference formulations suggested that doses required to meet human target serum concentrations in cats are markedly different.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2018 journal article
Diclazuril nonlinear mixed-effects pharmacokinetic modelling of plasma concentrations after oral administration to adult horses every 3-4 days
VETERINARY JOURNAL, 242, 74–76.
author keywords: Diclazuril; EPM; Prevention; Sarcocystis neurona
MeSH headings : Administration, Oral; Animals; Coccidiostats / administration & dosage; Coccidiostats / blood; Coccidiostats / pharmacokinetics; Drug Administration Schedule; Female; Horses / blood; Horses / metabolism; Male; Nitriles / administration & dosage; Nitriles / blood; Nitriles / pharmacokinetics; Triazines / administration & dosage; Triazines / blood; Triazines / pharmacokinetics
TL;DR:
Low dose diclazuril pellets produce steady-state plasma drug concentrations known to inhibit S. neurona and N. caninum, according to the mean population-derived peak concentration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: December 31, 2018
2018 journal article
Dosing Regimen of Enrofloxacin Impacts Intestinal Pharmacokinetics and the Fecal Microbiota in Steers
Frontiers in Microbiology, 9.
author keywords: antimicrobial resistance; fluoroquinolone; cattle; microbiome; pharmacokinetics
TL;DR:
Both dosing regimens of enrofloxacin achieve high concentrations in the intestinal lumen, and the rapid elimination mitigates long-term impacts on fecal E. coli resistance and the microbiota.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID, Web Of Science
Added: October 16, 2018
2018 chapter
Drugs for Treating Gastrointestinal Diseases
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 1245–1277). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.
Source: NC State University Libraries
Added: April 5, 2019
2018 chapter
Drugs that Affect the Respiratory System
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 1302–1320). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.
Source: NC State University Libraries
Added: April 5, 2019
2018 journal article
Pharmacodynamic assessment of diuretic efficacy and braking in a furosemide continuous infusion model
JOURNAL OF VETERINARY CARDIOLOGY, 20(2), 92–101.
author keywords: Lasix; Urine; Natriuresis; Aldosterone
MeSH headings : Aldosterone / urine; Animals; Diuretics / administration & dosage; Diuretics / blood; Diuretics / pharmacology; Diuretics / urine; Dogs; Electrolytes / urine; Furosemide / administration & dosage; Furosemide / blood; Furosemide / pharmacology; Furosemide / urine; Infusions, Intravenous; Male; Renin-Angiotensin System / drug effects
TL;DR:
The decrease in uNa:uK over time during the infusion is consistent with mineralocorticoid modification of urinary electrolyte excretion, supporting renin-angiotensin-aldosterone activation as a cause of diuretic braking in this model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2018 journal article
Pharmacokinetics and Pharmacodynamics of an Oral Formulation of Apixaban in Horses After Oral and Intravenous Administration
FRONTIERS IN VETERINARY SCIENCE, 5.
author keywords: factor Xa; direct oral anticoagulant; EHV-1; platelet activation; equine
TL;DR:
It is demonstrated that apixaban has no apparent clinical utility as an anticoagulant for horses due to poor oral availability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: December 17, 2018
2018 journal article
Pharmacokinetics of enrofloxacin and ciprofloxacin in Atlantic horseshoe crabs (Limulus polyphemus) after single injection
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 41(2), 349–353.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / pharmacokinetics; Ciprofloxacin / administration & dosage; Ciprofloxacin / analysis; Ciprofloxacin / pharmacokinetics; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / analysis; Fluoroquinolones / pharmacokinetics; Half-Life; Hemolymph / chemistry; Horseshoe Crabs / metabolism; Injections / veterinary; Male
TL;DR:
Concentrations that were achieved after a single dose of 5 mg/kg horseshoe crabs were sufficient to treat bacteria susceptible to enrofloxacin and ciprofl oxacin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2018 journal article
Pharmacokinetics of furosemide after intravenous, oral and transdermal administration to cats
Journal of Feline Medicine and Surgery, 1098612X1880587.
author keywords: Furosemide; pharmacokinetic; diuretic; transdermal; heart failure
MeSH headings : Administration, Cutaneous; Administration, Oral; Administration, Topical; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacokinetics; Animals; Biological Availability; Cats / metabolism; Female; Furosemide / administration & dosage; Furosemide / pharmacokinetics; Half-Life; Infusions, Intravenous / veterinary; Injections, Intravenous / veterinary; Male
TL;DR:
Furosemide was rapidly eliminated in cats after oral and IV administration and is probably best administered orally at least q12h in cats with heart failure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: February 27, 2019
2018 journal article
Pharmacokinetics of ketorolac in wild Eastern box turtles (Terrapene carolina carolina ) after single intramuscular administration
Journal of Veterinary Pharmacology and Therapeutics, 11.
MeSH headings : Analgesia / methods; Analgesia / veterinary; Analgesics / administration & dosage; Analgesics / blood; Analgesics / pharmacokinetics; Animals; Chromatography, High Pressure Liquid / veterinary; Female; Half-Life; Injections, Intramuscular / veterinary; Ketorolac / administration & dosage; Ketorolac / blood; Ketorolac / pharmacokinetics; Male; Turtles / blood; Turtles / metabolism
TL;DR:
It is concluded that this long T1/2 for a dose of 0.25 mg/kg ketorolac-injected IM provides plasma levels above a previously published target level for 24-hour analgesia to allow for once daily dosing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref
Added: February 11, 2019
2018 journal article
Population pharmacokinetics of ceftazidime after a single intramuscular injection in wild turtles
Journal of Veterinary Pharmacology and Therapeutics, 41(4), 495–501.
author keywords: ceftazidime; nonlinear mixed-effects modeling; pharmacokinetics; turtles
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Ceftazidime / administration & dosage; Ceftazidime / blood; Ceftazidime / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Injections, Intramuscular / veterinary; Turtles / blood; Turtles / metabolism
TL;DR:
This investigation used a population pharmacokinetic approach to study ceftazidime in wild turtles presented for rehabilitation, and concluded that this long T½ will allow for a dose of 20 mg/kg injected IM to maintain concentrations above the MIC of most wild-type bacteria for 5 days.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2018 journal article
Population pharmacokinetics of extended-release levetiracetam in epileptic dogs when administered alone, with phenobarbital or zonisamide
Journal of Veterinary Internal Medicine, 32(5), 1677–1683.
author keywords: antiepileptic drug; canine; drug disposition; drug interactions; seizures
MeSH headings : Animals; Anticonvulsants / administration & dosage; Anticonvulsants / pharmacokinetics; Anticonvulsants / therapeutic use; Delayed-Action Preparations; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Drug Interactions; Epilepsy / drug therapy; Epilepsy / veterinary; Levetiracetam / administration & dosage; Levetiracetam / pharmacokinetics; Levetiracetam / therapeutic use; Phenobarbital / administration & dosage; Phenobarbital / pharmacokinetics; Phenobarbital / therapeutic use; Zonisamide / administration & dosage; Zonisamide / pharmacokinetics; Zonisamide / therapeutic use
TL;DR:
Considerable variation exists in the pharmacokinetics of LEV‐XR in dogs with epilepsy being treated with a common dose regimen, and drug monitoring may be beneficial to determine the most appropriate dose of levetiracetam in individual dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: November 5, 2018
2018 journal article
The pharmacokinetics of cytarabine administered subcutaneously, combined with prednisone, in dogs with meningoencephalomyelitis of unknown etiology
Journal of Veterinary Pharmacology & Therapeutics, 41(5), 638–643.
Contributors: B. Pastina n, P. Early n, R. Bergman*, J. Nettifee n , A. Maller, K. Bray*, R. Waldron*, A. Castel*
author keywords: canine; cytarabine; MUE; Pharmacokinetics; sparse sampling; subcutaneous; canine; cytarabine; MUE; pharmacokinetics; sparse sampling; subcutaneous
MeSH headings : Animals; Antimetabolites, Antineoplastic / administration & dosage; Antimetabolites, Antineoplastic / blood; Antimetabolites, Antineoplastic / pharmacokinetics; Antimetabolites, Antineoplastic / therapeutic use; Cytarabine / administration & dosage; Cytarabine / blood; Cytarabine / pharmacokinetics; Cytarabine / therapeutic use; Dog Diseases / drug therapy; Dogs; Drug Combinations; Encephalomyelitis / drug therapy; Encephalomyelitis / veterinary; Female; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / blood; Immunosuppressive Agents / pharmacokinetics; Immunosuppressive Agents / therapeutic use; Injections, Subcutaneous; Male; Meningoencephalitis / drug therapy; Meningoencephalitis / veterinary; Prednisone / administration & dosage; Prednisone / blood; Prednisone / pharmacokinetics; Prednisone / therapeutic use
TL;DR:
The pharmacokinetics of CA in dogs with MUE after a single 50 mg/m2 SC injection in dogs was similar to what has been previously reported in healthy beagles; there was moderate variability in the population estimates in this clinical population of dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 19, 2018
2018 journal article
The pharmacokinetics of gabapentin in cats
JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(6), 1996–2002.
author keywords: compounded; feline; pain; transdermal
MeSH headings : Analgesics / administration & dosage; Analgesics / blood; Analgesics / pharmacokinetics; Animals; Cats / metabolism; Female; Gabapentin / administration & dosage; Gabapentin / blood; Gabapentin / pharmacokinetics; Half-Life; Injections, Intravenous / veterinary; Male
TL;DR:
Repeated oral dosing of gabapentin did not alter the drug's pharmacokinetics, making dose adjustments unnecessary with long‐term treatment, and the transdermal route is an inappropriate choice for drug administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: December 31, 2018
2018 book
Veterinary Pharmacology and Therapeutics
(10th ed.). Hoboken, New Jersey, USA: Wiley Blackwell. John Wiley & Sons.
Ed(s): R. Je & P. Mg
Source: NC State University Libraries
Added: March 9, 2019
2018 chapter
Veterinary Pharmacology: An Introduction to the Discipline
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 3–7). Hoboken, New Jersey: Wiley Blackwell, John Wiley & Sons.
Source: NC State University Libraries
Added: April 5, 2019
2018 chapter
β-Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 826–857). Hoboken, New Jersey, USA: Wiley Blackwell, John Wiley & Sons.
Source: NC State University Libraries
Added: April 5, 2019
2017 chapter
Antibacterial Drug Therapy
In S. J. Ettinger, E. C. Feldman, & E. Côté (Eds.), Textbook of Veterinary Internal Medicine: Disease of the Dog and the Cat (Eighth, pp. 683–687). St. Louis, Missouri: Elsevier.
Ed(s): S. Ettinger, E. Feldman & E. Côté
Source: NC State University Libraries
Added: April 13, 2019
2017 chapter
Antifungal and antiviral therapy
In S. J. Ettinger, E. C. Feldman, & E. Côté (Eds.), Textbook of Veterinary Internal Medicine: Disease of the Dog and the Cat (Eighth, pp. 688–692). St. Louis, Missouri: Elsevier.
Ed(s): S. Ettinger, E. Feldman & E. Côté
Source: NC State University Libraries
Added: April 5, 2019
2017 journal article
Antimicrobial use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases
Journal of Veterinary Internal Medicine, 31(2), 279–294.
author keywords: Bronchitis; Pneumonia; Pyothorax; Rhinitis
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacterial Infections / drug therapy; Bacterial Infections / veterinary; Cat Diseases / drug therapy; Cats; Dog Diseases / drug therapy; Dogs; Respiratory Tract Diseases / drug therapy; Respiratory Tract Diseases / veterinary
TL;DR:
The International Society for Companion Animal Infectious Diseases convened a Working Group of clinical microbiologists, pharmacologists, and internists to share experiences, examine scientific data, review clinical trials, and develop these guidelines to assist veterinarians in making antimicrobial treatment choices.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2017 journal article
CEFOVECIN PHARMACOKINETICS IN THE RED-EARED SLIDER
JOURNAL OF EXOTIC PET MEDICINE, 26(2), 108–113.
author keywords: chelonian; reptile; antibiotic; cephalosporin; protein binding
TL;DR:
Although well tolerated in red‐eared sliders, the rapid decline in plasma cefovecin concentration negates its use as a long‐acting antibiotic in this species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Cephalexin susceptibility breakpoint for veterinary isolates: Clinical Laboratory Standards Institute revision
Journal of Veterinary Diagnostic Investigation, 30(1), 113–120.
author keywords: Breakpoints; cephalexin; cephalothin; CLSI; Staphylococcus pseudintermedius; susceptibility testing
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Cats / microbiology; Cephalexin / pharmacology; Dogs / microbiology; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Staphylococcus / drug effects
TL;DR:
Cephalothin should not be used for susceptibility testing of cephalexin for veterinary bacterial pathogens, and canine-specific breakpoints should be used by CLSI for testing susceptibility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: February 27, 2019
2017 journal article
Chronic maladaptive pain in cats: A review of current and future drug treatment options
The Veterinary Journal, 230, 52–61.
author keywords: Maladaptive pain; Cats; Analgesia; Central plasticity; Chronic pain
MeSH headings : Analgesics / therapeutic use; Animals; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cats; Chronic Pain / diagnosis; Chronic Pain / drug therapy; Chronic Pain / veterinary; Forecasting; Pain Management / trends; Pain Management / veterinary; Pain Measurement / veterinary
TL;DR:
The current understanding of chronic or maladaptive pain, techniques for the detection and measurement of the condition and the associated central nervous changes, as well as an overview of the data evaluating potential therapeutics in cats are detailed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: February 11, 2019
2017 journal article
Ciprofloxacin Pharmacokinetics in Clinical Canine Patients
Journal of Veterinary Internal Medicine, 31(5), 1508–1513.
author keywords: Antibiotic; Canine; Fluoroquinolone; Nonlinear mixed-effects modeling
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Bacterial Infections / drug therapy; Bacterial Infections / veterinary; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Dog Diseases / drug therapy; Dog Diseases / microbiology; Dogs; Female; Half-Life; Male; Microbial Sensitivity Tests / veterinary; Monte Carlo Method; Prospective Studies
TL;DR:
The size of the dog was an important covariate with larger dogs achieving lower plasma drug concentrations than smaller dogs, despite a similar mg/kg dose, which is much lower than the breakpoint of ≤1 μg/mL in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: February 11, 2019
2017 journal article
Comparison of direct sampling and brochoalveolar lavage for determining active drug concentrations in the pulmonary epithelial lining fluid of calves injected with enrofloxacin or tilmicosin
Journal of Veterinary Pharmacology and Therapeutics, 40(6), e45–e53.
author keywords: antibiotic; bovine; lung
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / pharmacokinetics; Bronchoalveolar Lavage Fluid / chemistry; Cattle / metabolism; Enrofloxacin; Extracellular Fluid / chemistry; Fluoroquinolones / administration & dosage; Fluoroquinolones / analysis; Fluoroquinolones / pharmacokinetics; Injections, Subcutaneous / veterinary; Lung / chemistry; Male; Respiratory Mucosa / chemistry; Tylosin / administration & dosage; Tylosin / analogs & derivatives; Tylosin / analysis; Tylosin / pharmacokinetics
TL;DR:
Concentrations of enrofloxacin/ciprofl oxacin exceeded the MIC values for bovine respiratory disease pathogens but tilmicosin did not reach MIC levels for these pathogens in any fluids.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, Web Of Science
Added: February 27, 2019
2017 journal article
Considerations for using minocycline vs doxycycline for treatment of canine heartworm disease
Parasites & Vectors, 10(S2).
author keywords: Minocycline; Doxycycline; Wolbachia; Heartworm; Pharmacokinetics; Pharmacodynamics; Monte Carlo simulation
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Dirofilaria immitis / microbiology; Dirofilaria immitis / physiology; Dirofilariasis / drug therapy; Dirofilariasis / parasitology; Dog Diseases / drug therapy; Dog Diseases / parasitology; Dogs; Doxycycline / administration & dosage; Doxycycline / pharmacokinetics; Mice; Minocycline / administration & dosage; Minocycline / pharmacokinetics; Wolbachia / drug effects; Wolbachia / physiology
TL;DR:
Minocycline is an attractive option because of the higher cost of doxycycline and new pharmacokinetic information for dogs that provides guidance for appropriate dosage regimens to achieve pharmacokinetics-pharmacodynamic (PK-PD) targets, but more work is needed to document efficacy of minocyCline for treating canine heartworm disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Furosemide continuous rate infusion diluted with 5% dextrose in water or hypertonic saline in normal adult dogs: a pilot study
JOURNAL OF VETERINARY CARDIOLOGY, 19(1), 44–56.
author keywords: Lasix; Diuretic; Sodium; Salt
MeSH headings : Animals; Cross-Over Studies; Diuretics / administration & dosage; Diuretics / adverse effects; Diuretics / pharmacokinetics; Dogs; Furosemide / administration & dosage; Furosemide / adverse effects; Furosemide / pharmacokinetics; Glucose / administration & dosage; Infusions, Intravenous / veterinary; Male; Pilot Projects; Saline Solution, Hypertonic / administration & dosage; Single-Blind Method; Water
TL;DR:
Diuresis was similar for both furosemide CRI methods; however, the H-SAL method induced less renin-angiotensin-aldosterone system activation than the DEX method, suggesting that dilution of a furo Semine CRI with 2.4% hypertonic saline may be well tolerated in heart failure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Ketoprofen pharmacokinetics of R - and S -isomers in juvenile loggerhead sea turtles (Caretta caretta ) after single intravenous and single- and multidose intramuscular administration
Journal of Veterinary Pharmacology and Therapeutics, 41(2), 340–348.
author keywords: Caretta caretta; ketoprofen; loggerhead; nonsteroidal anti-inflammatory; pharmacokinetics
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Drug Administration Schedule / veterinary; Female; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Ketoprofen / administration & dosage; Ketoprofen / pharmacokinetics; Turtles / metabolism
TL;DR:
The S-isomer is the predominant isomer in loggerhead sea turtles, similar to most mammals, despite administration of a 50:50 racemic mixture, and a dose of 2 mg/kg either IM or IV every 24 hr is likely appropriate for loggerhead turtles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2017 journal article
New interpretive criteria for danofloxacin antibacterial susceptibility testing against Mannheimia haemolytica and Pasteurella multocida associated with bovine respiratory disease
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 29(2), 224–227.
author keywords: Clinical and Laboratory Standards Institute; clinical breakpoint; danofloxacin; interpretive criteria; Mannheimia; Pasteurella
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bovine Respiratory Disease Complex / drug therapy; Bovine Respiratory Disease Complex / epidemiology; Bovine Respiratory Disease Complex / microbiology; Cattle; Fluoroquinolones / pharmacology; Mannheimia haemolytica / drug effects; Microbial Sensitivity Tests / veterinary; North America / epidemiology; Pasteurella multocida / drug effects
TL;DR:
These newly established intermediate and resistant clinical breakpoint values have been endorsed by CLSI and can be used for interpreting results from antibacterial susceptibility testing of danofloxacin against M. haemolytica and P. multocida isolated from bovine respiratory disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Pharmacokinetics and Relative Bioavailability of Orally Administered Innovator-Formulated Itraconazole Capsules and Solution in Healthy Dogs
JOURNAL OF VETERINARY INTERNAL MEDICINE, 31(4), 1163–1169.
author keywords: Blastomycosis; Histoplasmosis; Mycology; Sporanox (R)
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / pharmacokinetics; Capsules; Cross-Over Studies; Dogs / metabolism; Female; Itraconazole / administration & dosage; Itraconazole / pharmacokinetics; Male; Solutions
TL;DR:
Overall drug exposures after capsule and solution administration are not substantially different in dogs, and formulation‐specific dosages do not appear to be necessary.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Pharmacokinetics of ampicillin-sulbactam in serum and synovial fluid samples following regional intravenous perfusion in the distal portion of a hind limb of adult cattle
AMERICAN JOURNAL OF VETERINARY RESEARCH, 78(12), 1372–1379.
MeSH headings : Administration, Intravenous / veterinary; Ampicillin / administration & dosage; Ampicillin / pharmacokinetics; Animals; Anti-Bacterial Agents / pharmacokinetics; Cattle; Chromatography, High Pressure Liquid / veterinary; Female; Hindlimb; Perfusion; Sulbactam / administration & dosage; Sulbactam / pharmacokinetics; Synovial Fluid / metabolism
TL;DR:
Potentially therapeutic concentrations of ampicillin were achieved in regional serum and SYN samples; SYN concentrations remained at potentially therapeutic values for > 12 hours following RIVP of 1.5 g of amicillin-sulbactam in the hind limb of healthy cows.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Pharmacokinetics of an extended-release formulation of eprinomectin in healthy adult alpacas and its use in alpacas confirmed with mange
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 40(2), 192–199.
MeSH headings : Animals; Area Under Curve; Camelids, New World / blood; Delayed-Action Preparations; Feces / parasitology; Female; Half-Life; Insecticides / administration & dosage; Insecticides / blood; Insecticides / pharmacology; Insecticides / therapeutic use; Ivermectin / administration & dosage; Ivermectin / analogs & derivatives; Ivermectin / blood; Ivermectin / pharmacokinetics; Ivermectin / therapeutic use; Male; Mite Infestations / drug therapy; Mite Infestations / veterinary; Parasite Egg Count
TL;DR:
Alpacas require a higher eprinomectin dose than cattle, to reach comparable plasma concentrations, and skin biopsies showed reduced hyperkeratosis, but increased fibrosis, with 1 of 4 alpacas remaining positive on skin scraping for mange.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Pharmacokinetics of intravenous clindamycin phosphate in captive Bennett's wallabies (Macropus rufogriseus)
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 40(6), 682–686.
author keywords: antibiotic; Bennett's wallaby; clindamycin; macropod; pharmacokinetics
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Clindamycin / administration & dosage; Clindamycin / analogs & derivatives; Clindamycin / blood; Clindamycin / pharmacokinetics; Female; Half-Life; Infusions, Intravenous / veterinary; Macropodidae / metabolism; Male
TL;DR:
The pharmacokinetic properties of a single intravenous (IV) dose of clindamycin were determined in six wallabies and no adverse effects were noted after IV administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Plasma and serum concentrations of cytarabine administered via continuous intravenous infusion to dogs with meningoencephalomyelitis of unknown etiology
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 40(4), 411–414.
Contributors: P. Early n, K. Crook, L. Williams*, E. Davis *, K. Muñana n , n , K. Messenger n
MeSH headings : Animals; Area Under Curve; Cytarabine / administration & dosage; Cytarabine / pharmacokinetics; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Encephalomyelitis / blood; Encephalomyelitis / drug therapy; Encephalomyelitis / veterinary; Infusions, Intravenous / veterinary
TL;DR:
The steady-state achieved with cytarabine CRI produces a consistent and prolonged exposure in plasma and serum, which is likely to produce equilibrium between blood and the central nervous system in dogs with a clinical diagnosis of MUE.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 chapter
Section Advisor: Therapeutic Considerations in Medicine and Disease
In S. J. Ettinger, E. C. Feldman, & E. Côté (Eds.), Textbook of Veterinary Internal Medicine: Disease of the Dog and the Cat (Eighth). St. Louis, Missouri: Elsevier.
Ed(s): S. Ettinger, E. Feldman & E. Côté
Source: NC State University Libraries
Added: April 13, 2019
2017 journal article
The effects of clopidogrel and omeprazole on platelet function in normal dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 40(2), 130–139.
MeSH headings : Animals; Blood Platelets / drug effects; Blood Platelets / physiology; Clopidogrel; Cross-Over Studies; Dogs / blood; Drug Therapy, Combination; Female; Male; Omeprazole / administration & dosage; Omeprazole / pharmacology; Platelet Aggregation Inhibitors / pharmacology; Platelet Function Tests; Proton Pump Inhibitors / pharmacology; Ticlopidine / administration & dosage; Ticlopidine / analogs & derivatives; Ticlopidine / pharmacology
TL;DR:
The concurrent administration of omeprazole and clopidogrel in healthy dogs was associated with an increase in the plasma concentration of an inactive metabolite of clopIDogrel, but does not significantly alter the antiplatelet effects of clopsinogrel.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Alternate-day dosing of itraconazole in healthy adult cats
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 39(1), 27–31.
MeSH headings : Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Cats / blood; Drug Administration Schedule; Half-Life; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics
TL;DR:
Overall, a 100 mg every other day oral dosage regimen for itraconazole in cats yielded serum concentrations with minimal fluctuation and with careful monitoring may be considered for treatment of cats with systemic fungal disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Antimicrobial susceptibility testing for feline urinary tract isolates
Journal of Feline Medicine and Surgery, 18(2), 183–184.
TL;DR:
The Veterinary Antimicrobial Susceptibility Testing (VAST) subcommittee of the Clinical and Laboratory Standards Institute (CLSI) with regard to the paper by Lund et al,1 ‘Antimicrobial susceptibility in bacterial isolates from Norwegian cats with lower urinary tract disease’ is written.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: March 2, 2019
2016 journal article
Assessment of in vitro release of carboplatin from six carrier media
AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(12), 1381–1386.
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Carboplatin / administration & dosage; Delayed-Action Preparations / administration & dosage; Drug Carriers / administration & dosage; Gelatin; Gels; Hemostatics; Microspheres; Neoplasms / drug therapy; Neoplasms / veterinary; Polymers
TL;DR:
The poloxamer copolymer gel and hemostatic gelatin sponge released carboplatin rapidly in vitro, whereas calcium sulfate beads did not.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Carprofen pharmacokinetics in plasma and in control and inflamed canine tissue fluid using in vivo ultrafiltration
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 39(1), 32–39.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Body Fluids / chemistry; Carbazoles / blood; Carbazoles / metabolism; Carbazoles / pharmacokinetics; Carrageenan / toxicity; Dinoprostone / metabolism; Dog Diseases / blood; Dog Diseases / chemically induced; Dog Diseases / metabolism; Dogs; Half-Life; Inflammation / chemically induced; Inflammation / metabolism; Inflammation / veterinary; Ultrafiltration / veterinary
TL;DR:
In vivo ultrafiltration is a reliable method to determine unbound carprofen in ISF, and that disposition of unbound drug into tissue is much higher than predicted from un bound drug concentration in plasma, however, concentrations and pharmacokinetic parameter estimates are not significantly different in inflamed vs. un-inflamed tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Comparison of active drug concentrations in the pulmonary epithelial lining fluid and interstitial fluid of calves injected with enrofloxacin, florfenicol, ceftiofur, or tulathromycin
PLoS One, 11(2), e0149100.
Ed(s): J. Torrelles
MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Biological Availability; Cattle; Cephalosporins / blood; Cephalosporins / pharmacokinetics; Cross-Over Studies; Disaccharides / blood; Disaccharides / pharmacokinetics; Enrofloxacin; Epithelial Cells / metabolism; Extracellular Fluid / chemistry; Extracellular Fluid / metabolism; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Lung / metabolism; Male; Mannheimia haemolytica / drug effects; Mannheimia haemolytica / growth & development; Microbial Sensitivity Tests; Respiratory Mucosa / metabolism; Thiamphenicol / analogs & derivatives; Thiamphenicol / blood; Thiamphenicol / pharmacokinetics; Veterinary Drugs / blood; Veterinary Drugs / pharmacokinetics
TL;DR:
The bronchial concentrations were higher than the plasma or interstitial concentrations, with over 900% penetration to the airways, and the tulathromycin concentrations achieved were lower than the MIC of susceptible bacteria at most time points.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: June 8, 2019
2016 journal article
Correction: Comparison of Active Drug Concentrations in the Pulmonary Epithelial Lining Fluid and Interstitial Fluid of Calves Injected with Enrofloxacin, Florfenicol, Ceftiofur, or Tulathromycin
PLOS ONE, 11(7), e0159219.
TL;DR:
This research presents a novel probabilistic procedure that allows for direct measurement of the response of the immune system to earthquake-triggered landsliding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: June 8, 2019
2016 chapter
Drug Formulary, Appendix IX
In L. P. Tilley & F. W. K. Smith (Eds.), Blackwells's Five Minute Veterinary Consult: Canine and Feline (6th ed., pp. 1445–1548). Wiley Blackwell.
Ed(s): L. Tilley & F. Smith
Source: NC State University Libraries
Added: April 5, 2019
2016 personal communication
How to (properly) determine the beyond-use date and stability of a compounded formulation for pets
Papich, M. G., Brown, S., & Kirk, L. (2016, April).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
How to (properly) determine the beyond-use date and stability of a compounded formulation for pets
Journal of Feline Medicine & Surgery, 18(4), 364–365.
Source: NC State University Libraries
Added: April 13, 2019
2016 journal article
POPULATION PHARMACOKINETICS OF ENROFLOXACIN AND ITS METABOLITE CIPROFLOXACIN IN THE GREEN SEA URCHIN (STRONGYLOCENTROTUS DROEBACHIENSIS) FOLLOWING INTRACOELOMIC AND IMMERSION ADMINISTRATION
Journal of Zoo and Wildlife Medicine, 47(1), 175–186.
author keywords: Ciprofloxacin; echinoderms; enrofloxacin; green sea urchin; pharmacokinetics; Strongylocentrotus droebachiensis
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Ciprofloxacin / administration & dosage; Ciprofloxacin / pharmacokinetics; Drug Administration Routes; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / pharmacokinetics; Strongylocentrotus / metabolism
TL;DR:
The concentrations of enrofloxacin achieved far exceeded minimum inhibitory concentrations reported for teleost pathogens, indicating minimal production of this metabolite in the green sea urchin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018
2016 journal article
Pharmacokinetics of detomidine following intravenous or oral-transmucosal administration and sedative effects of the oral-transmucosal treatment in dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(4), 413–420.
MeSH headings : Administration, Mucosal; Administration, Oral; Animals; Biological Availability; Chromatography, Liquid; Dexmedetomidine / administration & dosage; Dexmedetomidine / blood; Dexmedetomidine / pharmacokinetics; Dogs / metabolism; Female; Gels; Half-Life; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / blood; Hypnotics and Sedatives / pharmacokinetics; Imidazoles / administration & dosage; Imidazoles / blood; Imidazoles / pharmacokinetics; Infusions, Intravenous / veterinary; Male; Mass Spectrometry
TL;DR:
Detomidine gel administered by the OTM route provided sedation suitable for a short, minimally invasive procedure in healthy dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Pharmacokinetics of minocycline in domestic cats
JOURNAL OF FELINE MEDICINE AND SURGERY, 18(4), 257–263.
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Biological Availability; Cat Diseases / drug therapy; Cats; Chromatography, High Pressure Liquid / veterinary; Half-Life; Infusions, Intravenous; Microbial Sensitivity Tests; Minocycline / administration & dosage; Minocycline / pharmacokinetics
TL;DR:
The pharmacokinetics of minocycline in domestic cats was determined in order to facilitate dosage decisions and it was found that one 50 mg capsule orally q24h would provide appropriate dosing for most cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Pharmacokinetics of voriconazole after intravenous and oral administration to healthy cats
AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(9), 931–939.
MeSH headings : Administration, Intravenous; Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / pharmacokinetics; Biological Availability; Cats; Chemistry, Pharmaceutical; Cross-Over Studies; Half-Life; Suspensions; Tablets; Voriconazole / administration & dosage; Voriconazole / pharmacokinetics
TL;DR:
Voriconazole had excellent oral bioavailability and a long half-life in cats and increased plasma concentrations in the target range but increased, which suggested drug accumulation during long-term administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Population pharmacokinetics of a single dose of meloxicam after oral and intramuscular administration to captive lesser flamingos (Phoeniconaias minor)
American Journal of Veterinary Research, 77(12), 1311–1317.
MeSH headings : Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Biological Availability; Birds / blood; Birds / metabolism; Female; Half-Life; Injections, Intravenous / veterinary; Male; Meloxicam; Thiazines / administration & dosage; Thiazines / pharmacokinetics; Thiazoles / administration & dosage; Thiazoles / pharmacokinetics
TL;DR:
In lesser flamingos, oral administration of meloxicam resulted in higher bioavailability and a longer elimination half-life than did IM administration, but the maximum plasma concentration was low and may be insufficient to provide analgesia in flamingos.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
Population pharmacokinetics of enrofloxacin in purple sea stars (Pisaster ochraceus) following an intracoelomic injection or extended immersion
AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(11), 1266–1275.
MeSH headings : Animals; Chromatography, High Pressure Liquid; Enrofloxacin; Fluoroquinolones / pharmacokinetics; Half-Life; Injections, Intravenous; Microbial Sensitivity Tests; Starfish / metabolism
TL;DR:
Results suggested that the described enrofloxacin administration resulted in water vascular system fluid drug concentrations expected to exceed the minimum inhibitory concentration for many bacterial pathogens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Posaconazole Pharmacokinetics in Healthy Cats after Oral and Intravenous Administration
JOURNAL OF VETERINARY INTERNAL MEDICINE, 30(5), 1703–1707.
author keywords: Bioavailability; Blastomyces; Fungal infection; Histoplasma
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / pharmacokinetics; Area Under Curve; Cats; Female; Half-Life; Injections, Intravenous; Male; Triazoles / administration & dosage; Triazoles / pharmacokinetics
TL;DR:
Despite low PO absorption, these data allow for simulation of PO dosage regimens that could be explored in clinical studies, and two regimens can be considered to maintain targeted trough concentrations of 0.5–0.7 μg/mL as extrapolated from studies in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 book
Saunders Handbook of Veterinary Drugs
(Fourth). St. Louis, Missouri: Elsevier-Saunders.
Source: NC State University Libraries
Added: March 9, 2019
2015 journal article
ACVIM Consensus Statement on Therapeutic Antimicrobial Use in Animals and Antimicrobial Resistance
Journal of Veterinary Internal Medicine, 29(2), 487–498.
author keywords: Antibiotics; Antimicrobial stewardship; Public health; Therapeutics
MeSH headings : Animal Husbandry / methods; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / therapeutic use; Bacteria / drug effects; Bacterial Infections / drug therapy; Bacterial Infections / veterinary; Drug Resistance, Bacterial; Societies, Scientific / organization & administration; United States; Veterinary Drugs; Veterinary Medicine / organization & administration; Veterinary Medicine / standards
TL;DR:
This consensus statement aims to provide guidance on the therapeutic use of antimicrobials in animals, balancing the need for effective therapy with minimizing development of antimicrobial resistance in bacteria from animals and humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: February 27, 2019
2015 journal article
Antimicrobial stewardship in companion animal practice
Journal of the American Veterinary Medical Association, 246(3), 287–288.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Applying Biopharmaceutical Classification System (BCS) Criteria to Predict Oral Absorption of Drugs in Dogs: Challenges and Pitfalls
AAPS JOURNAL, 17(4), 948–964.
author keywords: BCS; dogs; canine; permeability; solubility
MeSH headings : Administration, Oral; Animals; Biological Availability; Biological Transport; Computer Simulation; Dogs; Drug Design; Humans; Models, Biological; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / classification; Solubility; Species Specificity
TL;DR:
The results of this assessment strongly suggest that the human BCS classification system requires substantial modification before it can be reliably applied to dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 journal article
Determination of thermodynamic solubility of active pharmaceutical ingredients for veterinary species: A new USP general chapter
Stimuli to the Revision Process. United States Pharmacopeia Pharmaceutical Forum, 41(3).
Source: NC State University Libraries
Added: April 5, 2019
2015 journal article
Effect of Chronic Administration of Phenobarbital, or Bromide, on Pharmacokinetics of Levetiracetam in Dogs with Epilepsy
JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(2), 614–619.
Contributors: K. Muñana n , J. Nettifee-Osborne n & n
author keywords: Antiepileptic drug; Canine; Drug disposition; Drug interactions; Seizures
MeSH headings : Animals; Anticonvulsants / administration & dosage; Anticonvulsants / pharmacokinetics; Anticonvulsants / therapeutic use; Area Under Curve; Bromides / administration & dosage; Bromides / therapeutic use; Dog Diseases / blood; Dog Diseases / drug therapy; Dog Diseases / metabolism; Dogs; Epilepsy / blood; Epilepsy / drug therapy; Epilepsy / veterinary; Half-Life; Levetiracetam; Phenobarbital / administration & dosage; Phenobarbital / therapeutic use; Piracetam / administration & dosage; Piracetam / analogs & derivatives; Piracetam / pharmacokinetics; Piracetam / therapeutic use
TL;DR:
Significant Dosage increases might be indicated when utilizing LEV as add‐on treatment with phenobarbital in dogs when administered concurrently with conventional AEDs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 journal article
Effect of feeding on the pharmacokinetics of oral minocycline in healthy research dogs
Veterinary Dermatology, 26(6), 399–405.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Evaluation of canine- specific minocycline and doxycycline susceptibility breakpoints for meticillin-resistant Staphylococcus pseudintermedius isolates from dogs
Veterinary Dermatology, 26(5), 334–338.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Evaluation of the Effect of Orally Administered Acid Suppressants on Intragastric pH in Cats
JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(1), 104–112.
author keywords: Bravo monitoring; Famotidine; Feline; Omeprazole
MeSH headings : Animals; Antacids / administration & dosage; Antacids / pharmacokinetics; Antacids / pharmacology; Anti-Ulcer Agents / administration & dosage; Anti-Ulcer Agents / pharmacology; Area Under Curve; Cats / physiology; Cross-Over Studies; Famotidine / pharmacology; Half-Life; Hydrogen-Ion Concentration; Monitoring, Physiologic / instrumentation; Monitoring, Physiologic / veterinary; Ointments; Omeprazole / administration & dosage; Omeprazole / pharmacokinetics; Omeprazole / pharmacology; Stomach / physiology; Tablets
TL;DR:
Fractionated enteric‐coated OT is an effective acid suppressant despite disruption of the enteric coating and both omeprazole formulations provide superior acid suppression in cats compared to famotidine or placebo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 chapter
Nonsteroidal anti-inflammatory drugs
In K. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), Lumb & Jones' Veterinary Anesthesia and Analgesia (5th ed., pp. 227–243). Wiley Blackwell.
Ed(s): K. Grimm, L. Lamont, W. Tranquilli, S. Greene & S. Robertson
Source: NC State University Libraries
Added: April 5, 2019
2015 journal article
Opinions of clinical veterinarians at a US veterinary teaching hospital regarding antimicrobial use and antimicrobial-resistant infections
Journal of the American Veterinary Medical Association, 247(8), 938–944.
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacteria / drug effects; Bacterial Infections / microbiology; Bacterial Infections / veterinary; Cross-Sectional Studies; Data Collection; Drug Resistance, Bacterial; Education, Veterinary; Female; Hospitals, Animal; Humans; Male; Professional Practice; Schools, Veterinary; United States; Veterinarians
TL;DR:
Findings indicated that veterinarians at this teaching hospital were concerned about antimicrobial resistance, thought antimicrobials were overprescribed, and supported restricting use of certain antimicrobial classes in companion animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2015 journal article
PHARMACOKINETICS OF SINGLE-DOSE ORALLY ADMINISTERED CIPROFLOXACIN IN CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 46(2), 266–272.
author keywords: Antibiotic; California sea lion; ciprofloxacin; fluoroquinolone; pharmacokinetic; marine mammal
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Dose-Response Relationship, Drug; Sea Lions / blood
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 journal article
Pharmacokinetics and distribution of voriconazole in body fluids of dogs after repeated oral dosing
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 38(5), 451–456.
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / analysis; Antifungal Agents / blood; Antifungal Agents / cerebrospinal fluid; Antifungal Agents / pharmacokinetics; Aqueous Humor / chemistry; Chromatography, High Pressure Liquid / veterinary; Dogs; Female; Male; Microbial Sensitivity Tests / veterinary; Synovial Fluid / chemistry; Voriconazole / administration & dosage; Voriconazole / analysis; Voriconazole / blood; Voriconazole / cerebrospinal fluid; Voriconazole / pharmacokinetics
TL;DR:
Results of this study suggest that twice daily, administration may be necessary to maintain therapeutic plasma concentrations in dogs but further studies are warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 journal article
Pharmacokinetics of a low dose and FDA-labeled dose of diclazuril administered orally as a pelleted topdressing in adult horses
Journal of Veterinary Pharmacology and Therapeutics, 38(3), 243–248.
MeSH headings : Administration, Oral; Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / blood; Antiprotozoal Agents / cerebrospinal fluid; Antiprotozoal Agents / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Drug Administration Schedule / veterinary; Female; Horses / metabolism; Male; Nitriles / administration & dosage; Nitriles / blood; Nitriles / cerebrospinal fluid; Nitriles / pharmacokinetics; Triazines / administration & dosage; Triazines / blood; Triazines / cerebrospinal fluid; Triazines / pharmacokinetics
TL;DR:
Results of this study show that diclazuril pellets given at the approved label dose and a lower dose both produce similar plasma drug concentrations at steady-state and attain plasma and CSF concentrations known to inhibit Sarcocystis neurona in cell culture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Pharmacokinetics of enrofloxacin and ceftiofur in plasma, interstitial fluid, and gastrointestinal tract of calves after subcutaneous injection, and bactericidal impacts on representative enteric bacteria
Journal of Veterinary Pharmacology and Therapeutics, 39(1), 62–71.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Cattle / blood; Cephalosporins / administration & dosage; Cephalosporins / blood; Cephalosporins / metabolism; Cephalosporins / pharmacokinetics; Drug Resistance, Bacterial; Enrofloxacin; Enterococcus faecalis / drug effects; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / metabolism; Fluoroquinolones / pharmacokinetics; Half-Life; Intestines / microbiology; Microbial Sensitivity Tests; Salmonella enterica / drug effects
TL;DR:
Enrofloxacin and ceftiofur achieved intestinal concentrations capable of reducing intestinal bacteria, yet the short exposure of ceftIOfur in the intestine may select for resistant organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: March 2, 2019
2015 journal article
Plasma Drug Concentrations of Orally Administered Rosuvastatin in Hispaniolan Amazon Parrots (Amazona ventralis)
JOURNAL OF AVIAN MEDICINE AND SURGERY, 29(1), 18–24.
author keywords: atherosclerosis; statins; rosuvastatin; avian; Hispaniolan Amazon parrot; Amazona ventralis
MeSH headings : Administration, Oral; Amazona / blood; Animals; Fluorobenzenes / administration & dosage; Fluorobenzenes / blood; Fluorobenzenes / pharmacokinetics; Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage; Hydroxymethylglutaryl-CoA Reductase Inhibitors / blood; Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacokinetics; Pyrimidines / administration & dosage; Pyrimidines / blood; Pyrimidines / pharmacokinetics; Rosuvastatin Calcium; Sulfonamides / administration & dosage; Sulfonamides / blood; Sulfonamides / pharmacokinetics
TL;DR:
Results indicate that rosuvastatin does not appear suitable in Amazon parrots as compounded and used at the dose in this study, and pharmacodynamic studies investigating lipid-lowering effects of statins rather than pharmacokinetic studies may be more practical and cost effective in future studies to screen for a statin with more ideal properties.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 journal article
Plasma concentrations of lidocaine in dogs following lidocaine patch application over an incision compared to intact skin
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 38(6), 575–580.
MeSH headings : Anesthetics, Local / administration & dosage; Anesthetics, Local / blood; Anesthetics, Local / pharmacokinetics; Animals; Dogs / blood; Dogs / surgery; Female; Lidocaine / administration & dosage; Lidocaine / blood; Lidocaine / pharmacokinetics; Male; Skin / metabolism; Transdermal Patch
TL;DR:
It is demonstrated that the actual body exposure to lidocaine was significantly higher when an incision was present compared to intact skin, and the AUC was significantlyHigher in the Incision Group.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 journal article
Posaconazole pharmacokinetics after administration of an intravenous solution, oral suspension, and delayed-release tablet to dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 76(5), 454–459.
MeSH headings : Administration, Intravenous / veterinary; Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / pharmacokinetics; Biological Availability; Chromatography, High Pressure Liquid / veterinary; Cross-Over Studies; Delayed-Action Preparations / administration & dosage; Delayed-Action Preparations / pharmacokinetics; Dogs / metabolism; Female; Half-Life; Male; Suspensions / administration & dosage; Suspensions / pharmacokinetics; Tablets / administration & dosage; Tablets / pharmacokinetics; Triazoles / administration & dosage; Triazoles / pharmacokinetics
TL;DR:
Absorption of the delayed-release tablets was greater than absorption of the oral suspension, with a longer t1/2 that may favor its clinical use in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 chapter
Strategies for Treating Infections in Critically Ill Patients
In Small Animal Critical Care Medicine (pp. 949–955).
Sources: Crossref, ORCID
Added: February 27, 2019
2015 journal article
The AVMA Task Force for Antimicrobial Stewardship in Companion Animal Practice responds
Journal of the American Veterinary Medical Association, 246(7), 727–728.
Source: NC State University Libraries
Added: April 17, 2019
2015 personal communication
The AVMA task force for antimicrobial stewardship in companion animal practice responds
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Understanding companion animal practitioners' attitudes toward antimicrobial stewardship
Journal of the American Veterinary Medical Association, 247(8), 883–884.
Source: NC State University Libraries
Added: August 6, 2018
2014 chapter
Antibacterial Drugs
In Canine and Feline Infectious Diseases (pp. 66–86).
Sources: Crossref, ORCID
Added: February 27, 2019
2014 chapter
Antifungal Drugs
In Canine and Feline Infectious Diseases (pp. 87–96).
Sources: Crossref, ORCID
Added: February 27, 2019
2014 chapter
Antiprotozoal Drugs
In Canine and Feline Infectious Diseases (pp. 97–104).
Sources: Crossref, ORCID
Added: February 27, 2019
2014 chapter
Antiviral and Immunomodulatory Drugs
In Canine and Feline Infectious Diseases (pp. 54–65).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: February 27, 2019
2014 journal article
Bioequivalence of Orally Administered Generic, Compounded, and Innovator-Formulated Itraconazole in Healthy Dogs
JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(1), 72–77.
author keywords: Bioavailability; Blastomyces; Fungal infection; Histoplasma; Pneumonia
MeSH headings : Animals; Area Under Curve; Cross-Over Studies; Dogs / metabolism; Drug Compounding / veterinary; Drugs, Generic / administration & dosage; Drugs, Generic / analysis; Drugs, Generic / pharmacokinetics; Half-Life; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics; Random Allocation; Therapeutic Equivalency
TL;DR:
Neither generic nor compounded itraconazole is bioequivalent to the reference formulation in dogs, however, pharmacokinetic data for generic formulation were similar enough that therapeutic concentrations could be achieved.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 chapter
Consulting Editor, Appendix I, Table of Common Drugs: Approximate Dosages
In J. D. Bonagura & D. C. Twedt (Eds.), Kirk’s Current Veterinary Therapy XV (pp. 1307–1335). Saunders- Elsevier.
Ed(s): J. Bonagura & D. Twedt
Source: NC State University Libraries
Added: April 5, 2019
2014 journal article
Efficacy of enrofloxacin in a mouse model of sepsis
Journal of the American Association for Laboratory Animal Science, 53(4), 381–386.
Source: NC State University Libraries
Added: August 6, 2018
2014 review
Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases)
[Review of ]. Veterinary Dermatology, 25(3), 163-.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases)
Veterinary Dermatology, 25(3), 163–175.
Source: NC State University Libraries
Added: April 13, 2019
2014 journal article
Implantation of an ultrafiltration device in the ileum and spiral colon of steers to continuously collect intestinal fluid
Research in Veterinary Science, 97(3), 611–615.
author keywords: Bovine; Gastrointestinal fluid; Surgery; Ultrafiltration
MeSH headings : Animals; Body Fluids; Cattle; Colon / surgery; Ileum / surgery; Intestinal Secretions; Specimen Handling / methods; Specimen Handling / veterinary; Ultrafiltration / instrumentation
TL;DR:
Use of ultrafiltration probes is a novel, consistent and humane method to repeatedly sample the gastrointestinal contents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: March 2, 2019
2014 journal article
Meloxicam pharmacokinetics using nonlinear mixed-effects modeling in ferrets after single subcutaneous administration
Journal of Veterinary Pharmacology and Therapeutics, 37(4), 382–387.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Female; Ferrets / blood; Ferrets / metabolism; Half-Life; Injections, Subcutaneous; Male; Meloxicam; Sex Factors; Thiazines / administration & dosage; Thiazines / pharmacokinetics; Thiazoles / administration & dosage; Thiazoles / pharmacokinetics
TL;DR:
Sex differences in the pharmacokinetic behavior of meloxicam should be taken into consideration when treating ferrets, as these animals are considered effective in other species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2014 journal article
Minocycline pharmacokinetics and pharmacodynamics in dogs: dosage recommendations for treatment of meticillin-resistant Staphylococcus pseudintermedius infections
Veterinary Dermatology, 25(3), 182–e47.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / pharmacology; Area Under Curve; Cross-Over Studies; Dog Diseases / drug therapy; Dog Diseases / microbiology; Dogs; Dose-Response Relationship, Drug; Half-Life; Methicillin Resistance; Minocycline / administration & dosage; Minocycline / blood; Minocycline / pharmacokinetics; Minocycline / pharmacology; Staphylococcal Skin Infections / drug therapy; Staphylococcal Skin Infections / veterinary; Staphylococcus / drug effects; Tissue Distribution
TL;DR:
This study provides dosage recommendations for therapy of meticillin-resistant Staphylococcus pseudintermedius infections in dogs and provides PK/PD data necessary to consider species-specific clinical breakpoints for minocycline susceptibility testing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
PHARMACOKINETICS OF SINGLE DOSE ORAL MELOXICAM IN BOTTLENOSE DOLPHINS (TURSIOPS TRUNCATUS)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 45(3), 594–599.
author keywords: Bottlenose dolphin; pharmacokinetics; meloxicam; Tursiops truncatus
MeSH headings : Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Bottle-Nosed Dolphin / blood; Female; Male; Meloxicam; Thiazines / administration & dosage; Thiazines / blood; Thiazines / pharmacokinetics; Thiazoles / administration & dosage; Thiazoles / blood; Thiazoles / pharmacokinetics
TL;DR:
The elimination of meloxicam in cetaceans was slower than in other species, with an elimination half-life of almost 70 hr, and detectable drug concentrations up to 7 days, suggesting that a single oral dose of 0.1 mg/kg appears safe for use in this species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 article
Pharmacokinetic-pharmacodynamic (PK-PD) modeling and the rational selection of dosage regimes for the prudent use of antimicrobial drugs
Papich, M. G. (2014, July 16). VETERINARY MICROBIOLOGY, Vol. 171, pp. 480–486.
author keywords: Antimicrobial; Antibiotic; Pharmacokinetic; Pharmacodynamic; Monte Carlo simulation; Resistance
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Cephalosporins / administration & dosage; Cephalosporins / pharmacokinetics; Drug Dosage Calculations; Drug Resistance, Microbial; Inappropriate Prescribing / prevention & control; Inappropriate Prescribing / veterinary; Microbial Sensitivity Tests; Models, Biological; Monte Carlo Method; Time Factors; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
It is the goal of the CLSI subcommittee that these revised breakpoints will encourage more effective antimicrobial use and avoid unnecessary antimicrobial administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Pharmacokinetic-pharmacodynamic values for amoxicillin in pigs
American Journal of Veterinary Research, 75(4), 316.
MeSH headings : Amoxicillin / pharmacology; Animals; Anti-Bacterial Agents / pharmacology; Bacterial Infections / veterinary; Monte Carlo Method; Swine / blood; Swine Diseases / drug therapy
Sources: NC State University Libraries, ORCID
Added: April 14, 2019
2014 journal article
Pharmacokinetics and preliminary safety data of a single oral dose of bosentan, a dual endothelin receptor antagonist, in cats
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 37(2), 192–195.
MeSH headings : Administration, Oral; Animals; Antihypertensive Agents / administration & dosage; Antihypertensive Agents / adverse effects; Antihypertensive Agents / pharmacokinetics; Bosentan; Cats / blood; Half-Life; Male; Statistics as Topic; Sulfonamides / administration & dosage; Sulfonamides / adverse effects; Sulfonamides / pharmacokinetics
TL;DR:
Further evaluation of repeat dosing, investigation into the in vivo efficacy of decreasing endothelin-1 concentrations in cats, as well as safety in conjunction with other medications is warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Plasma and synovial fluid concentration of doxycycline following low-dose, low-frequency administration, and resultant inhibition of matrix metalloproteinase-13 from interleukin-stimulated equine synoviocytes
EQUINE VETERINARY JOURNAL, 46(2), 198–202.
author keywords: synovial fluid; osteoarthritis; doxycycline; horse; MMP
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Cells, Cultured; Cross-Over Studies; Dose-Response Relationship, Drug; Doxycycline / administration & dosage; Doxycycline / blood; Doxycycline / chemistry; Doxycycline / pharmacokinetics; Drug Administration Schedule; Gene Expression Regulation, Enzymologic / drug effects; Horses; Matrix Metalloproteinase 13 / genetics; Matrix Metalloproteinase 13 / metabolism; Matrix Metalloproteinase Inhibitors / administration & dosage; Matrix Metalloproteinase Inhibitors / blood; Matrix Metalloproteinase Inhibitors / chemistry; Matrix Metalloproteinase Inhibitors / pharmacokinetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Synovial Fluid / chemistry; Synovial Membrane / cytology
TL;DR:
This study supports the use of doxycycline as a disease modifying osteoarthritic drug and achieves SF concentrations in vivo capable of diminishing MMP-13 expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 chapter
Principles of Antiinfective Therapy
In Canine and Feline Infectious Diseases (pp. 46–53).
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, ORCID
Added: February 27, 2019
2014 chapter
Respiratory drug therapy
In J. D. Bonagura & D. C. Twedt (Eds.), Kirk’s Current Veterinary Therapy XV (pp. 622–628). Saunders-Elsevier.
Ed(s): J. Bonagura & D. Twedt
Source: NC State University Libraries
Added: April 5, 2019
2014 journal article
Response to letter from J Mottet “Comments on the ISCAID Guidelines on the use of antimicrobial therapies in canine superficial bacterial folliculitis”
Response to letter from J Mottet “Comments on the ISCAID Guidelines on the use of antimicrobial therapies in canine superficial bacterial folliculitis.” Veterinary Dermatology, 25(6), 567–568.
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Dog Diseases / diagnosis; Folliculitis / veterinary; Skin Diseases, Bacterial / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018
2014 journal article
Workshop report: The 2012 Antimicrobial Agents in Veterinary Medicine: exploring the consequences of antimicrobial drug use: a 3-D approach
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 37(1), E1–E16.
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacterial Infections / drug therapy; Bacterial Infections / microbiology; Bacterial Infections / veterinary; Drug Resistance, Bacterial; Drug Utilization / standards; Humans; Veterinary Medicine / standards
TL;DR:
This report aims to provide a summary of the presentations and discussions occurring during the 2012 AAVM with the goal of stimulating future discussions and enhancing the opportunity to establish creative and sustainable solutions that will guarantee the availability of an effective therapeutic arsenal for veterinary species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Antibiotic Treatment of Resistant Infections in Small Animals
Veterinary Clinics of North America: Small Animal Practice, 43(5), 1091–1107.
author keywords: Antibiotics; Resistance; Infection; Small animals
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Bacterial Infections / drug therapy; Bacterial Infections / microbiology; Bacterial Infections / veterinary; Cat Diseases / drug therapy; Cat Diseases / microbiology; Cats; Dog Diseases / drug therapy; Dog Diseases / microbiology; Dogs; Drug Resistance, Bacterial
TL;DR:
There are few veterinary clinical studies to support a recommended use and dose for treating resistant bacterial infections in small animals and a susceptibility test is needed to identify the appropriate drug for these infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2013 chapter
Antimicrobial drugs
In R. J. Washabau & M. J. Day (Eds.), Canine and Feline Gastroenterology (pp. 471–476). St. Louis, Missouri: Elsevier Saunders.
Ed(s): R. Washabau & M. Day
Source: NC State University Libraries
Added: April 5, 2019
2013 journal article
Antimicrobials, Susceptibility Testing, and Minimum Inhibitory Concentrations (MIC) in Veterinary Infection Treatment
Veterinary Clinics of North America: Small Animal Practice, 43(5), 1079–1089.
author keywords: Antimicrobials; Minimum inhibitory concentration; Susceptibility testing; Veterinary infection treatment
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Bacteria / drug effects; Bacterial Infections / drug therapy; Bacterial Infections / microbiology; Bacterial Infections / veterinary; Bacteriological Techniques; Dogs; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Veterinary Drugs
TL;DR:
There are many reasons why antimicrobial treatment fails and when evaluating a patient that has failed to respond to therapy, one must consider any of the many factors that contribute to antibiotic failure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Assessment of Plasma Concentrations and Potential Adverse Effects of Doxycycline in Cockatiels (Nymphicus hollandicus) Fed a Medicated Pelleted Diet
JOURNAL OF AVIAN MEDICINE AND SURGERY, 27(3), 187–193.
author keywords: Chlamydophila psittaci; spiral bacteria; antimicrobial drug; doxycycline; pharmacology; avian; cockatiel; Nymphicus hollandicus
MeSH headings : Animal Feed / analysis; Animals; Anti-Bacterial Agents / adverse effects; Anti-Bacterial Agents / blood; Cockatoos / blood; Doxycycline / adverse effects; Doxycycline / blood; Food Handling; Time Factors
TL;DR:
This medicated diet may be suitable for treating spiral bacteria and Chlamydophila psittaci infections in cockatiels that will consume a pelleted diet.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Doxycycline concentration over time after storage in a compounded veterinary preparation
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 242(12), 1674–1678.
MeSH headings : Anti-Bacterial Agents / chemistry; Chemistry, Pharmaceutical; Doxycycline / chemistry; Drug Compounding; Drug Stability; Drug Storage; Suspensions; Time Factors; Veterinary Drugs / chemistry
TL;DR:
The concentration of doxycycline compounded from commercial tablets in the vehicles evaluated to yield doses of 33.3 and 166.7 mg/mL cannot be assured beyond 7 days, and the quality of the formulations decreased as well.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 chapter
Drug therapy for diseases of the central nervous system
In S. R. Platt & N. J. Olby (Eds.), BSAVA Manual of Canine and Feline Neurology (4th ed., pp. 452–469). Gloucester: British Small Animal Veterinary Association.
Ed(s): S. Platt & N. Olby
Source: NC State University Libraries
Added: April 13, 2019
2013 journal article
Elution of antimicrobials from a cross-linked dextran gel: In vivo Quantification
EQUINE VETERINARY JOURNAL, 45(2), 148–153.
author keywords: horse; antibiotic delivery device; local antimicrobial; elution; biodegradable
MeSH headings : Amikacin / administration & dosage; Amikacin / blood; Amikacin / pharmacokinetics; Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Clindamycin / administration & dosage; Clindamycin / blood; Clindamycin / pharmacokinetics; Delayed-Action Preparations; Dextrans / chemistry; Drug Implants; Horses / blood; Microbial Sensitivity Tests; Vancomycin / administration & dosage; Vancomycin / blood; Vancomycin / pharmacokinetics
TL;DR:
Cross-linked dextran gel is a safe, effective alternative local antimicrobial delivery method for treatment and wound healing when implanted subcutaneously in horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Identifying antimicrobial resistance
Journal of the American Veterinary Medical Association, 243(11), 1517–1518.
Source: NC State University Libraries
Added: April 13, 2019
2013 journal article
Pharmacodynamics of Doxycycline and Tetracycline against Staphylococcus pseudintermedius: Proposal of Canine-Specific Breakpoints for Doxycycline
JOURNAL OF CLINICAL MICROBIOLOGY, 51(11), 3547–3554.
MeSH headings : Animals; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / pharmacology; Dog Diseases / drug therapy; Dog Diseases / microbiology; Dogs; Doxycycline / pharmacokinetics; Doxycycline / pharmacology; Microbial Sensitivity Tests; Models, Theoretical; Staphylococcal Infections / drug therapy; Staphylococcal Infections / microbiology; Staphylococcal Infections / veterinary; Staphylococcus / drug effects; Tetracycline / pharmacokinetics; Tetracycline / pharmacology
TL;DR:
Doxycycline was more active than tetracycline in non-wild-type strains and the two drugs displayed bacteriostatic activity and bimodal MIC distributions, and canine-specific doxycycline MIC breakpoints were proposed based on the data generated in this study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Ronidazole pharmacokinetics in cats following delivery of a delayed-release guar gum formulation
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(4), 399–407.
MeSH headings : Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / blood; Antiprotozoal Agents / pharmacokinetics; Area Under Curve; Cats / blood; Cats / metabolism; Delayed-Action Preparations; Galactans / chemistry; Half-Life; Male; Mannans / chemistry; Plant Gums / chemistry; Ronidazole / administration & dosage; Ronidazole / blood; Ronidazole / pharmacokinetics; Tablets
TL;DR:
Delayed release of ronidazole from guar gum-coated tablets indicates that release of RDZ may be delayed to deliver the medication to a targeted area of the intestine in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Stability of three commonly compounded extemporaneous enrofloxacin suspensions for oral administration to exotic animals
Journal of the American Veterinary Medical Association, 243(1), 85–90.
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Drug Compounding; Drug Stability; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / chemistry; Pets; Suspensions / chemistry
TL;DR:
Results indicated that, when stored in amber-colored vials at room temperature for 56 days, the enrofloxacin concentration strength in all 3 formulations was retained within acceptance criteria of 90% to 110%.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2013 journal article
The pharmacokinetics of cytarabine in dogs when administered via subcutaneous and continuous intravenous infusion routes
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(4), 408–411.
Contributors: K. Crook n, P. Early n, K. Messenger n, K. Muñana n , R. Gallagher n & n
MeSH headings : Animals; Antimetabolites, Antineoplastic / administration & dosage; Antimetabolites, Antineoplastic / blood; Antimetabolites, Antineoplastic / pharmacokinetics; Area Under Curve; Cross-Over Studies; Cytarabine / administration & dosage; Cytarabine / blood; Cytarabine / pharmacokinetics; Dogs / blood; Dogs / metabolism; Half-Life; Infusions, Intravenous / veterinary; Injections, Subcutaneous / veterinary
TL;DR:
The steady state achieved with the cyTarabine CRI may produce a more prolonged exposure of cytarabine at cytotoxic levels in plasma compared to the concentrations after SC administration, as these are two routes of administration commonly employed in the treatment of meningitis of unknown etiology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
The pharmacokinetics of midazolam after intravenous, intramuscular, and rectal administration in healthy dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(5), 471–477.
Contributors: M. Schwartz n, K. Muñana n , J. Nettifee-Osborne n, K. Messenger n & n
MeSH headings : Administration, Rectal; Animals; Anticonvulsants / administration & dosage; Anticonvulsants / blood; Anticonvulsants / pharmacokinetics; Chromatography, High Pressure Liquid; Dogs; Female; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Male; Midazolam / administration & dosage; Midazolam / blood; Midazolam / pharmacokinetics
TL;DR:
It is suggested that IM midazolam might be useful in treating seizures in dogs when venous access is unavailable, but higher doses may be needed to account for intermediate bioavailability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
The use of oral transmucosal detomidine hydrochloride gel to facilitate handling in dogs
JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH, 8(3), 114–123.
author keywords: detomidine; alpha-2 agonist; sedation; anxiety; dogs; oral transmucosal
TL;DR:
Although further evaluation is warranted for use in client-owned dogs, OTM detomidine gel offers a novel sedative and anxiolytic option to facilitate handling of canine subjects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Tissue distribution of enrofloxacin in African clawed frogs (Xenopus laevis) after intramuscular and subcutaneous administration
Journal of the American Association for Laboratory Animal Science, 52(2), 186–188.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Twice-daily dosing of RDZ no longer recommended for treatment of intestinal Tritrichomonas foetus infection
Journal of Feline Medicine and Surgery, 16(2), 198–198.
MeSH headings : Animals; Cat Diseases / parasitology; Intestinal Diseases, Parasitic / veterinary; Protozoan Infections, Animal / parasitology; Tritrichomonas foetus / isolation & purification
TL;DR:
Based on the recent feline RDZ pharmacokinetic (PK) studies, it is no longer recommend twice-daily dosing of RDZ, and cats are not inadvertently overdosed and risk neurologic sequelae based on outdated recommendations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2012 journal article
Ciprofloxacin pharmacokinetics and oral absorption of generic ciprofloxacin tablets in dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(7), 1085–1091.
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Biological Availability; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Cross-Over Studies; Dogs / metabolism; Drugs, Generic / administration & dosage; Drugs, Generic / analysis; Drugs, Generic / pharmacokinetics; Half-Life; Random Allocation; Tablets
TL;DR:
Inconsistent oral absorption of ciprofloxacin in some dogs may be formulation dependent and affected by tablet dissolution in the small intestine, as well as pharmacokinetic-pharmacodynamic target concentration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 review
Dosing Regimen Matters: the Importance of Early Intervention and Rapid Attainment of the Pharmacokinetic/Pharmacodynamic Target
[Review of ]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56(6), 2795–2805.
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / pharmacology; Dose-Response Relationship, Drug; Drug Administration Schedule; Early Medical Intervention; Humans
TL;DR:
This minireview provides an overview of published evidence supporting the positions that, in most situations, it is the exposure achieved during the first dose that is relevant for determining the therapeutic outcome of an infection and therapeutic intervention should be initiated as soon as possible to minimize the size of the bacterial burden at the infection site.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Drug solubility classification in the dog
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35, 87–91.
MeSH headings : Administration, Oral; Animals; Dogs; Dosage Forms; Gastrointestinal Tract / physiology; Humans; Solubility; Veterinary Drugs / administration & dosage; Veterinary Drugs / chemistry; Veterinary Drugs / pharmacokinetics; Veterinary Drugs / pharmacology
TL;DR:
The impact of body size vs. administered dose and gastric volume on the estimated gastric drug concentration that needs to be considered and the human pH criteria for evaluating drug Solubility can be used when evaluating drug solubility of oral medications in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Florfenicol pharmacokinetics in healthy adult alpacas after subcutaneous and intramuscular injection
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(4), 382–388.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Camelids, New World / blood; Cross-Over Studies; Female; Injections, Intramuscular; Injections, Subcutaneous; Male; Thiamphenicol / administration & dosage; Thiamphenicol / analogs & derivatives; Thiamphenicol / pharmacokinetics
TL;DR:
The lowest effective dose of florfenicol should be used in alpacas and limited to treatment of highly susceptible pathogens, using a randomized, cross-over design, and 28-day washout period.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Pharmacokinetics and distribution of minocycline in mature horses after oral administration of multiple doses and comparison with minimum inhibitory concentrations
EQUINE VETERINARY JOURNAL, 44(4), 453–458.
author keywords: horse; minocycline; pharmacokinetics; synovial fluid; cerebral spinal fluid; aqueous humour; minimum inhibitory concentrations
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Aqueous Humor / chemistry; Area Under Curve; Bacteria / drug effects; Drug Administration Schedule; Female; Half-Life; Horses / blood; Horses / cerebrospinal fluid; Horses / metabolism; Male; Microbial Sensitivity Tests; Minocycline / administration & dosage; Minocycline / chemistry; Minocycline / pharmacokinetics; Pilot Projects; Synovial Fluid / chemistry; Tissue Distribution
TL;DR:
The use of orally administered minocycline at a dose of 4 mg/kg bwt every 12 h for the treatment of nonocular infections caused by susceptible (MIC ≤ 0.25 µg/ml) organisms in horses is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Pharmacokinetics of diminazene diaceturate in healthy cats
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(6), 608–610.
MeSH headings : Animals; Antiprotozoal Agents / blood; Antiprotozoal Agents / pharmacokinetics; Area Under Curve; Cats / blood; Chromatography, High Pressure Liquid; Diminazene / analogs & derivatives; Diminazene / blood; Diminazene / pharmacokinetics; Female; Half-Life; Male
TL;DR:
The pharmacokinetic profile of diminazene diaceturate in cats was characterized and it was found that this drug, if found to be effective for the treatment of C. felis, would offer advantages both in practicality of dosing and in cost.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Selection of antibiotics for meticillin-resistant Staphylococcus pseudintermedius: time to revisit some old drugs?
Veterinary Dermatology, 23(4), 352–360.
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Methicillin Resistance; Staphylococcal Skin Infections / drug therapy; Staphylococcal Skin Infections / microbiology; Staphylococcal Skin Infections / veterinary; Staphylococcus / classification; Staphylococcus / drug effects
TL;DR:
The aim of this review is to consider systemic therapy options for meticillin-resistant Staphylococcus pseudintermedius (MRSP), which is, by definition, resistant to all β-lactam antibiotics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Single-dose pharmacokinetics of ceftazidime and fluconazole during concurrent clinical use in cold-stunned Kemp's ridley turtles (Lepidochelys kempii)
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(1), 82–89.
MeSH headings : Animal Husbandry; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Antifungal Agents / administration & dosage; Antifungal Agents / pharmacokinetics; Ceftazidime / administration & dosage; Ceftazidime / pharmacokinetics; Cold Temperature; Fluconazole / administration & dosage; Fluconazole / pharmacokinetics; Turtles / blood; Turtles / metabolism
TL;DR:
Results indicate that the ceftazidime dose and dosing interval used in this study are likely to be effective in treating susceptible strains of bacteria in Kemp's ridley turtles, but the fluconazole dose andDosing interval are not likely to been effective against filamentous fungal pathogens that are often involved in marine turtle fungal infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 chapter
Solubility criteria for veterinary drugs
In Stimuli Article. http://www.usp.org/sites/default/files/usp_pdf/en/s200600.pdf
Source: NC State University Libraries
Added: April 5, 2019
2011 journal article
Antimicrobial use guidelines for treatment of urinary tract disease in dogs and cats: antimicrobial guidelines working group of the international society for companion animal infectious diseases
Veterinary Medicine International Epub, 2011, 1–9.
Sources: NC State University Libraries, ORCID, Crossref
Added: April 13, 2019
2011 journal article
Diazepam pharmacokinetics after nasal drop and atomized nasal administration in dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 34(1), 17–24.
MeSH headings : Administration, Intranasal; Animals; Anticonvulsants / administration & dosage; Anticonvulsants / blood; Anticonvulsants / pharmacokinetics; Diazepam / administration & dosage; Diazepam / blood; Diazepam / pharmacokinetics; Dogs; Dosage Forms; Drug Administration Routes; Female; Half-Life; Male; Nordazepam / blood; Nordazepam / metabolism; Oxazepam / blood; Oxazepam / metabolism
TL;DR:
This study confirms that i.n. administration of diazepam yields rapid anticonvulsant concentrations of d Xanax in the dog before a hepatic first-pass effect, and exceeds previously published bioavailability data for rectal administration ofdiazepam in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Distribution of enrofloxacin and its active metabolite, using an in vivo ultrafiltration sampling technique after the injection of enrofloxacin to pigs
Journal of Veterinary Pharmacology and Therapeutics, 35(5), 452–459.
Contributors: K. Messenger n, n & A. Blikslager n
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Bacteria / drug effects; Ciprofloxacin / blood; Ciprofloxacin / metabolism; Ciprofloxacin / pharmacokinetics; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / metabolism; Fluoroquinolones / pharmacokinetics; Half-Life; Injections, Subcutaneous; Microbial Sensitivity Tests; Swine / blood
TL;DR:
It is demonstrated that the concentration of biologically active enrofloxacin in tissues exceeds the concentration predicted by the unbound fraction in pig plasma, and is sufficient for the pathogens that cause respiratory infections in pigs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2011 journal article
Distribution of enrofloxacin and its active metabolite, using an in vivo ultrafiltration sampling technique after the injection of enrofloxacin to pigs
Journal of Veterinary Pharmacology & Therapeutics, 9.
Sources: NC State University Libraries, ORCID
Added: April 13, 2019
2011 journal article
Effects of Clopidogrel and Aspirin on Platelet Aggregation, Thromboxane Production, and Serotonin Secretion in Horses
JOURNAL OF VETERINARY INTERNAL MEDICINE, 25(1), 116–122.
author keywords: Antiplatelet agents; Laminitis; SR 26334; Thrombosis
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Area Under Curve; Aspirin / pharmacokinetics; Aspirin / pharmacology; Blood Platelets / drug effects; Blood Platelets / physiology; Clopidogrel; Cross-Over Studies; Female; Horses / blood; Horses / physiology; Male; Platelet Activation / drug effects; Platelet Aggregation Inhibitors / pharmacology; Platelet Count / veterinary; Prospective Studies; Random Allocation; Serotonin / blood; Thrombosis / prevention & control; Thrombosis / veterinary; Thromboxane B2 / biosynthesis; Thromboxane B2 / blood; Ticlopidine / analogs & derivatives; Ticlopidine / pharmacokinetics; Ticlopidine / pharmacology
TL;DR:
Clopidogrel effectively decreases ADP-induced platelet aggregation in horses, and could have therapeutic applications for equine diseases associated with platelet activation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Evaluation of intermittent infusion of bupivacaine into surgical wounds of dogs postoperatively
VETERINARY JOURNAL, 190(2), 287–289.
author keywords: Bupivacaine; Local anesthesia; Wound infusion; Dog; Analgesia; Post-operative pain
MeSH headings : Anesthetics, Local / pharmacokinetics; Anesthetics, Local / therapeutic use; Animals; Bupivacaine / pharmacokinetics; Bupivacaine / therapeutic use; Dogs / surgery; Double-Blind Method; Infusions, Intralesional / veterinary; Pain Measurement / veterinary; Pain, Postoperative / drug therapy; Pain, Postoperative / veterinary; Postoperative Care / veterinary; Prospective Studies; Recovery of Function; Wound Healing
TL;DR:
Bupivacaine infusion into surgical wounds after surgery may improve post-operative recovery, but no effect on wound tenderness was demonstrated in this study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Florfenicol pharmacokinetics in healthy adult alpacas after subcutaneous and intramuscular injection
Journal of Veterinary Pharmacology & Therapeutics, 8.
Sources: NC State University Libraries, ORCID
Added: April 13, 2019
2011 book
Handbook of Antimicrobial Therapy for Small Animals
St. Louis, Missouri: Elsevier-Saunders.
Source: NC State University Libraries
Added: March 9, 2019
2011 journal article
In Vitro Elution of Amikacin and Ticarcillin from a Resorbable, Self-Setting, Fiber Reinforced Calcium Phosphate Cement
VETERINARY SURGERY, 40(5), 563–570.
MeSH headings : Absorbable Implants; Amikacin / administration & dosage; Amikacin / pharmacokinetics; Amikacin / pharmacology; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / pharmacology; Bone Cements; Calcium Phosphates; Disk Diffusion Antimicrobial Tests; Drug Carriers; Drug Combinations; Escherichia coli / drug effects; In Vitro Techniques; Klebsiella pneumoniae / drug effects; Polyglactin 910; Staphylococcus aureus / drug effects; Ticarcillin / administration & dosage; Ticarcillin / pharmacokinetics; Ticarcillin / pharmacology
TL;DR:
FRCP beads with amikacin or ticarcillin/clavulanate, but not the combination, are suitable carriers for wound implantation and underscore the importance of testing drug combinations, despite success of the combination systemically, before their use in local applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 article
Leflunomide pharmacokinetics after single oral administration to dogs
Singer, L. M., Cohn, L. A., Reinero, C. R., & Papich, M. G. (2011, December). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 34, pp. 609–611.
MeSH headings : Administration, Oral; Animals; Chromatography, High Pressure Liquid / veterinary; Crotonates / blood; Crotonates / pharmacokinetics; Dogs / blood; Drug Administration Schedule / veterinary; Female; Half-Life; Hydroxybutyrates; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / blood; Immunosuppressive Agents / pharmacokinetics; Isoxazoles / administration & dosage; Isoxazoles / blood; Isoxazoles / pharmacokinetics; Leflunomide; Linear Models; Nitriles; Toluidines / blood; Toluidines / pharmacokinetics
TL;DR:
Leflunomide has been used as an adjunctive therapy for dogs refractory to traditional immunosuppressive drugs and to prevent anti-allograft immune responses and all procedures were approved by the NIH Guide for the Care and Use of Laboratory Animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Pharmacokinetics and antinociceptive effects of oral tramadol hydrochloride administration in Greyhounds
AMERICAN JOURNAL OF VETERINARY RESEARCH, 72(2), 256–262.
MeSH headings : Administration, Oral; Analgesics, Opioid / blood; Analgesics, Opioid / metabolism; Analgesics, Opioid / pharmacokinetics; Analgesics, Opioid / therapeutic use; Animals; Area Under Curve; Dogs / blood; Female; Half-Life; Male; Pain / drug therapy; Pain / veterinary; Tramadol / blood; Tramadol / metabolism; Tramadol / pharmacokinetics; Tramadol / therapeutic use
TL;DR:
Oral tramadol administration yielded antinociceptive effects in Greyhounds, but plasma concentrations of tramadl and O-desmethyltramadol were lower than expected.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Pharmacokinetics and distribution of minocycline in mature horses after oral administration of multiple doses and comparison with minimum inhibitory concentrations
Equine Veterinary Journal, 9.
Sources: NC State University Libraries, ORCID
Added: April 13, 2019
2011 journal article
Pharmacokinetics of diminazene diaceturate in healthy cats
Journal of Veterinary Pharmacology & Therapeutics, 12.
Sources: NC State University Libraries, ORCID
Added: April 13, 2019
2011 article
Pharmacokinetics of orally administered phenobarbital in African grey parrots (Psittacus erithacus erithacus)
Powers, L. V., & Papich, M. G. (2011, December). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 34, pp. 615–617.
MeSH headings : Administration, Oral; Animals; Anticonvulsants / administration & dosage; Anticonvulsants / blood; Anticonvulsants / pharmacokinetics; Female; Fluorescence Polarization Immunoassay / veterinary; Half-Life; Male; Parrots / blood; Phenobarbital / administration & dosage; Phenobarbital / blood; Phenobarbital / pharmacokinetics
TL;DR:
This investigation was performed to examine the pharmacokinetics of orally administered phenobarbital in African grey parrots and to present this as a preliminary report that can potentially serve as a basis for further study.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Plasma Concentrations of Fluconazole After a Single Oral Dose and Administration in Drinking Water in Cockatiels (Nymphicus hollandicus)
JOURNAL OF AVIAN MEDICINE AND SURGERY, 25(1), 23–31.
author keywords: fluconazole; yeast; Candida; pharmacokinetics; compounding; avian; cockatiel; Nymphicus hollandicus
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Cockatoos / blood; Fluconazole / administration & dosage; Fluconazole / blood; Fluconazole / pharmacokinetics; Water
TL;DR:
Investigation of the disposition of fluconazole in cockatiels (Nymphicus hollandicus) after single oral dose administration and to determine if therapeutic plasma concentrations could be safely achieved by providing medicated water found it to be possible to maintain plasma concentrations in mostcockatiels that exceed the minimum inhibitory concentration of 90% or therapeutic AUC ∶ MIC of most strains of Candida albicans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Ronidazole pharmacokinetics after intravenous and oral immediate-release capsule administration in healthy cats
JOURNAL OF FELINE MEDICINE AND SURGERY, 13(4), 244–250.
MeSH headings : Administration, Oral; Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / pharmacokinetics; Biological Availability; Cat Diseases / drug therapy; Cats / metabolism; Cross-Over Studies; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Metabolic Clearance Rate; Protozoan Infections, Animal / drug therapy; Random Allocation; Ronidazole / administration & dosage; Ronidazole / pharmacokinetics; Tritrichomonas foetus / drug effects
TL;DR:
The high oral bioavailability of RDZ and slow elimination may predispose cats to neurotoxicity with twice-daily administration, and less frequent administration should be considered for further study of effective treatment of T foetus-infected cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 book
Saunders Handbook of Veterinary Drugs
(Third). St. Louis, Missouri: Elsevier-Saunders.
Source: NC State University Libraries
Added: March 29, 2019
2011 journal article
The pharmacokinetics and in vitro cyclooxygenase selectivity of deracoxib in horses
Journal of Veterinary Pharmacology and Therapeutics, 34(1), 12–16.
Contributors: J. Davis*, J. Marshall*, n , A. Blikslager* & N. Campbell n
MeSH headings : Animals; Cyclooxygenase Inhibitors / blood; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / pharmacology; Horses / blood; Horses / metabolism; Sulfonamides / blood; Sulfonamides / pharmacokinetics; Sulfonamides / pharmacology
TL;DR:
It is shown that deracoxib is absorbed in the horse after oral administration, and may offer a useful alternative for anti-inflammatory treatment of various conditions in the dog and horse.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2011 journal article
The pharmacokinetics of levetiracetam in healthy dogs concurrently receiving phenobarbital
Journal of Veterinary Pharmacology and Therapeutics, 34(1), 31–34.
Contributors: S. Moore n, K. Muñana n , n & J. Nettifee-Osborne n
MeSH headings : Absorption; Animals; Anticonvulsants / blood; Anticonvulsants / pharmacokinetics; Area Under Curve; Dogs / blood; Drug Interactions; Half-Life; Levetiracetam; Phenobarbital / pharmacokinetics; Piracetam / analogs & derivatives; Piracetam / blood; Piracetam / pharmacokinetics
TL;DR:
Conurrent PB administration significantly alters the pharmacokinetics of LEV in the dog, indicating that dosage adjustments might be necessary when the drug is administered with PB.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2010 chapter
Antibacterial Drug Therapy
In S. J. Ettinger & E. C. Feldman (Eds.), Textbook of Veterinary Internal Medicine (7th ed., pp. 589–595). St. Louis, Missouri, USA: Saunders Elsevier.
Ed(s): S. Ettinger & E. Feldman
Source: NC State University Libraries
Added: April 13, 2019
2010 personal communication
Clarification on drugs used to treat leishmaniasis
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Clarification on drugs used to treat leishmaniasis
Journal of the American Veterinary Medical Association, 237(5), 493.
Source: NC State University Libraries
Added: April 14, 2019
2010 review
EFFECTS OF COMPOUNDING ON PHARMACOKINETICS OF ITRACONAZOLE IN BLACK-FOOTED PENGUINS (SPHENISCUS DEMERSUS)
[Review of ]. JOURNAL OF ZOO AND WILDLIFE MEDICINE, 41(3), 487–495.
author keywords: Black-footed penguin; Spheniscus demersus; itraconazole; compounding; pharmacokinetics
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / chemistry; Antifungal Agents / pharmacokinetics; Area Under Curve; Drug Compounding; Half-Life; Itraconazole / administration & dosage; Itraconazole / chemistry; Itraconazole / pharmacokinetics; Pilot Projects; Spheniscidae / blood; Spheniscidae / metabolism
TL;DR:
Absorption of itraconazole was significantly higher for the commercial formulation when compared to the compounded formulation, likely as a result of the presence of cyclodextrin, a carrier compound shown to improve oral absorption, in thecommercial formulation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Efficacy of Oral Famotidine and 2 Omeprazole Formulations for the Control of Intragastric pH in Dogs
Journal of Veterinary Internal Medicine, 25(1), 47–54.
author keywords: Acid disorders; Gastroenterology; Gastrointestinal
MeSH headings : Administration, Oral; Animals; Anti-Ulcer Agents / administration & dosage; Anti-Ulcer Agents / pharmacology; Cross-Over Studies; Dogs / metabolism; Famotidine / administration & dosage; Famotidine / pharmacology; Female; Gastric Acidity Determination / veterinary; Gastric Mucosa / metabolism; Hydrogen-Ion Concentration / drug effects; Male; Omeprazole / administration & dosage; Omeprazole / pharmacology; Stomach / drug effects; Telemetry / veterinary
TL;DR:
Oral omeprazole tablet and RP provide superior gastric acid suppression to famotidine, and should therefore be considered more effective for the treatment of acid related disorders in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018
2010 journal article
Evaluation of Pharmacokinetic-Pharmacodynamic Relationships for BioRelease Meloxicam Formulations in Horses
JOURNAL OF EQUINE VETERINARY SCIENCE, 30(10), 539–544.
author keywords: Meloxicam; Nonsteroidal anti-inflammatory drugs; Controlled release formulation
TL;DR:
Results from the present study suggest that potential therapeutic advantages of meloxicam may be enhanced by applying recent advances in biodegradable controlled release drug delivery, allowing single administration products to replace multiple daily treatment protocols.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Exploration of developmental approaches to companion animal antimicrobials: Providing for the unmet therapeutic needs of dogs and cats
Journal of Veterinary Pharmacology and Therapeutics, 33(2), 196–201.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Levetiracetam pharmacokinetics in healthy dogs following oral administration of single and multiple doses
AMERICAN JOURNAL OF VETERINARY RESEARCH, 71(3), 337–341.
Contributors: S. Moore, K. Muñana* , * & J. Nettifee-Osborne
MeSH headings : Administration, Oral; Animals; Anticonvulsants / administration & dosage; Anticonvulsants / blood; Anticonvulsants / pharmacokinetics; Area Under Curve; Chromatography, High Pressure Liquid; Dogs; Half-Life; Kinetics; Levetiracetam; Metabolic Clearance Rate; Piracetam / administration & dosage; Piracetam / analogs & derivatives; Piracetam / blood; Piracetam / pharmacokinetics
TL;DR:
Results indicated that the pharmacokinetics of LEV did not change appreciably after administration of multiple doses over 7 days, within the therapeutic range established for LEV in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Orally administered doxycycline accumulates in synovial fluid compared to plasma
EQUINE VETERINARY JOURNAL, 42(3), 208–212.
author keywords: horse; doxycycline; osteoarthritis; synovial fluid; MMP
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Dose-Response Relationship, Drug; Doxycycline / administration & dosage; Doxycycline / analysis; Doxycycline / blood; Doxycycline / pharmacokinetics; Half-Life; Horses; Synovial Fluid / chemistry
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Pharmacodynamic and pharmacokinetic evaluation of clopidogrel and the carboxylic acid metabolite SR 26334 in healthy dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 71(7), 822–830.
MeSH headings : Adenosine Diphosphate / pharmacology; Animals; Blood Coagulation / drug effects; Blood Platelets / drug effects; Blood Platelets / physiology; Carboxylic Acids / metabolism; Clopidogrel; Cytochrome P-450 Enzyme System / drug effects; Cytochrome P-450 Enzyme System / metabolism; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation / drug effects; Platelet Aggregation Inhibitors / pharmacokinetics; Platelet Aggregation Inhibitors / pharmacology; Reference Values; Ticlopidine / analogs & derivatives; Ticlopidine / pharmacokinetics; Ticlopidine / pharmacology
TL;DR:
Clopidogrel inhibited ADP-induced platelet aggregation in healthy dogs and may be a viable antiplatelet agent for use in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Pharmacokinetics and toxicity of ciprofloxacin in adult horses
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 33(6), 587–594.
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / toxicity; Ciprofloxacin / administration & dosage; Ciprofloxacin / pharmacokinetics; Ciprofloxacin / toxicity; Colitis / chemically induced; Colitis / veterinary; Endotoxemia / chemically induced; Endotoxemia / veterinary; Female; Half-Life; Horse Diseases / chemically induced; Horses / metabolism; Injections, Intravenous / veterinary; Male
TL;DR:
Adverse events included mild transient diarrhea to severe colitis, endotoxemia and laminitis necessitating euthanasia of three horses on humane grounds, and the high incidences of adverse events preclude oral and rapid i.v. push administration of ciprofloxacin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Pharmacokinetics of meloxicam following intravenous and oral administration in green iguanas (Iguana iguana)
American Journal of Veterinary Research, 71(11), 1277–1283.
MeSH headings : Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / toxicity; Area Under Curve; Blood Cells / drug effects; Blood Cells / physiology; Body Weight; Female; Iguanas / physiology; Injections, Intravenous; Kidney / drug effects; Kidney / pathology; Male; Meloxicam; Pain / drug therapy; Pain / veterinary; Stomach / drug effects; Stomach / pathology; Thiazines / administration & dosage; Thiazines / blood; Thiazines / pharmacokinetics; Thiazines / toxicity; Thiazoles / administration & dosage; Thiazoles / blood; Thiazoles / pharmacokinetics; Thiazoles / toxicity
TL;DR:
Results suggested that administration of meloxicam at a dose of 0.2 mg/kg IV or PO in green iguanas would result in plasma concentrations > 0.1 μg/mL for approximately 24 hours.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2010 journal article
Pharmacokinetics of voriconazole after oral administration of single and multiple doses in Hispaniolan Amazon parrots (Amazona ventralis)
AMERICAN JOURNAL OF VETERINARY RESEARCH, 71(4), 460–467.
MeSH headings : Administration, Oral; Amazona / metabolism; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / adverse effects; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Area Under Curve; Drug Administration Schedule; Half-Life; Pyrimidines / administration & dosage; Pyrimidines / adverse effects; Pyrimidines / blood; Pyrimidines / pharmacokinetics; Triazoles / administration & dosage; Triazoles / adverse effects; Triazoles / blood; Triazoles / pharmacokinetics; Voriconazole
TL;DR:
In Hispaniolan Amazon parrots, oral administration of voriconazole was associated with proportional kinetics following administration of single doses and a decrease in plasma concentration after administration of multiple doses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Pharmacokinetics, protein binding, and tissue distribution of orally administered cefpodoxime proxetil and cephalexin in dogs
American Journal of Veterinary Research, 71(12), 1484–1491.
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Bacteria / drug effects; Bacteria / isolation & purification; Ceftizoxime / administration & dosage; Ceftizoxime / analogs & derivatives; Ceftizoxime / pharmacokinetics; Cell Division / drug effects; Cephalexin / administration & dosage; Cephalexin / metabolism; Cephalexin / pharmacokinetics; Chromatography, High Pressure Liquid; Cross-Over Studies; Dogs; Intestinal Absorption; Kinetics; Protein Binding
TL;DR:
The effect of protein binding on the pharmacokinetics and distribution from plasma to interstitial fluid (ISF) of cephalexin and cefpodoxime proxetil in dogs was determined to be similar to that of the protein-unbound plasma concentration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: March 2, 2019
2010 personal communication
Proposed changes to Clinical Laboratory Standards Institute interpretive criteria for methicillin-resistant Staphylococcus pseudintermedius isolated from dogs
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Proposed changes to Clinical Laboratory Standards Institute interpretive criteria for methicillin-resistant Staphylococcus pseudintermedius isolated from dogs
Journal of Veterinary Diagnostic Investigation, 22(1), 160.
Source: NC State University Libraries
Added: April 13, 2019
2010 journal article
The Pharmacokinetics of Enrofloxacin in Adult African Clawed Frogs (Xenopus laevis)
Journal American Association Laboratory Animal Science, 49(6), 800–804.
Source: NC State University Libraries
Added: April 13, 2019
2010 personal communication
Thoughts on testing methods for bacterial isolates
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Thoughts on testing methods for bacterial isolates (On behalf of CLSI VAST subcommittee)
Journal of the American Veterinary Medical Association, 236(2), 162.
Source: NC State University Libraries
Added: April 14, 2019
2009 personal communication
Appreciation for study on bromide administration in dogs
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Appreciation for study on bromide administration in dogs
Journal of the American Veterinary Medical Association, 235(6), 659.
Source: NC State University Libraries
Added: April 14, 2019
2009 journal article
Assessment of clotrimazole gels for in vitro stability and in vivo retention in the frontal sinus of dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 70(5), 640–647.
MeSH headings : Animals; Antifungal Agents / chemistry; Antifungal Agents / metabolism; Antifungal Agents / pharmacokinetics; Clotrimazole / chemistry; Clotrimazole / metabolism; Clotrimazole / pharmacokinetics; Dogs / metabolism; Drug Stability; Frontal Sinus / diagnostic imaging; Frontal Sinus / metabolism; Gels / chemistry; Gels / metabolism; Male; Poloxamer / chemistry; Poloxamer / metabolism; Tomography, X-Ray Computed / veterinary
TL;DR:
Poloxamer gels had the most promise for improving drug contact within the frontal sinus of dogs, while limiting the inflammatory response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 chapter
Beta-Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed.). Ames, Iowa, USA: Wiley-Blackwell Publishing.
Source: NC State University Libraries
Added: April 17, 2019
2009 chapter
Chloramphenicol and Derivatives, Macrolides, Lincosamides, and Miscellaneous Antimicrobials
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed.). Ames, Iowa, USA: Wiley-Blackwell Publishing.
Source: NC State University Libraries
Added: April 17, 2019
2009 journal article
Comparative Activity of Pradofloxacin, Enrofloxacin, and Azithromycin against Bartonella henselae Isolates Collected from Cats and a Human
Journal of Clinical Microbiology, 48(2), 617–618.
MeSH headings : Angiomatosis, Bacillary / microbiology; Angiomatosis, Bacillary / veterinary; Animals; Anti-Bacterial Agents / pharmacology; Azithromycin / pharmacology; Bartonella henselae / drug effects; Bartonella henselae / isolation & purification; Cat Diseases / microbiology; Cat-Scratch Disease / microbiology; Cats; Enrofloxacin; Fluoroquinolones / pharmacology; Humans; Microbial Sensitivity Tests
TL;DR:
It is concluded that pradofloxacin may prove useful for the treatment of B. henselae infections and showed greater antimicrobial activity than did other antibiotics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2009 journal article
Effects of compounding and storage conditions on stability of pergolide mesylate
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 234(3), 385–389.
MeSH headings : Administration, Oral; Animals; Dopamine Agonists / chemistry; Dopamine Agonists / standards; Dopamine Agonists / therapeutic use; Drug Compounding / methods; Drug Compounding / standards; Drug Compounding / veterinary; Drug Stability; Drug Storage / standards; Horse Diseases / drug therapy; Horses; Light; Pergolide / chemistry; Pergolide / standards; Pergolide / therapeutic use; Pharmaceutical Solutions / chemistry; Pharmaceutical Solutions / standards; Pharmaceutical Solutions / therapeutic use; Pituitary ACTH Hypersecretion / drug therapy; Pituitary ACTH Hypersecretion / veterinary; Temperature; Time Factors
TL;DR:
Results indicated that pergolide mesylate was unstable after compounding in an aqueous vehicle and that storage conditions had an effect on stability of the compounded formulation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 review
Factors Influencing the Gastric Residence of Dosage Forms in Dogs
[Review of ]. JOURNAL OF PHARMACEUTICAL SCIENCES, 98(3), 844–860.
author keywords: preclinical pharmacology; gastrointestinal transit; bioavailability; food effects; oral absorption
MeSH headings : Administration, Oral; Animals; Dogs; Dosage Forms; Drug Evaluation, Preclinical / methods; Drug Evaluation, Preclinical / veterinary; Gastric Emptying; Humans
TL;DR:
An appreciation of the variables influencing canine gastric transit time is of interest both because of the push to develop pharmaceutical products that meet the therapeutic needs of the veterinary patient and because of efforts to improve understanding of the strengths and weaknesses associated with the use of the dog as a preclinical model to support human product development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Molecular mechanisms of Bartonella henselae resistance to azithromycin, pradofloxacin and enrofloxacin
Journal of Antimicrobial Chemotherapy, 65(3), 581–582.
author keywords: in vitro resistant mutants; disc diffusion assay; bartonellosis; DNA gyrase A; 23S rRNA
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Azithromycin / pharmacology; Bacteremia / microbiology; Bacterial Proteins / genetics; Bartonella henselae / drug effects; Bartonella henselae / genetics; Bartonella henselae / isolation & purification; Cat Diseases / microbiology; Cats; DNA Gyrase / genetics; DNA Mutational Analysis; DNA, Bacterial / genetics; Drug Resistance, Bacterial; Enrofloxacin; Fluoroquinolones / pharmacology; Mutation; Polymerase Chain Reaction; RNA, Ribosomal, 23S / genetics; Sequence Analysis, DNA
TL;DR:
In vitro results might explain relapses or treatment failures in vivo when using azithromycin as the sole antibiotic for treatment of cats infected with B. henselae, and many independent lines of evidence indicate that adenosine 2058 is the key nucleotide involved in macrolide interaction with the bacterial ribosome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2009 journal article
Pharmacokinetics of 4-aminopyridine derivatives in dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 32(5), 485–491.
MeSH headings : 4-Aminopyridine / analogs & derivatives; 4-Aminopyridine / blood; 4-Aminopyridine / cerebrospinal fluid; 4-Aminopyridine / pharmacokinetics; Administration, Oral; Animals; Dogs; Dose-Response Relationship, Drug; Female; Male; Potassium Channel Blockers / administration & dosage; Potassium Channel Blockers / blood; Potassium Channel Blockers / cerebrospinal fluid; Potassium Channel Blockers / pharmacokinetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Pharmacokinetics of an immediate and extended release oral morphine formulation utilizing the spheroidal oral drug absorption system in dogs
Journal of Veterinary Pharmacology and Therapeutics, 32(2), 129–136.
MeSH headings : Administration, Oral; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Chromatography, High Pressure Liquid / veterinary; Delayed-Action Preparations; Dogs / blood; Dogs / metabolism; Dose-Response Relationship, Drug; Female; Half-Life; Male; Morphine / administration & dosage; Morphine / blood; Morphine / pharmacokinetics; Pain / drug therapy; Pain / veterinary; Time Factors
TL;DR:
The specific oral morphine formulation used in this study produced sustained plasma morphine concentrations over 24 h compared with previous intravenous dosing and immediate-release oral morphine studies, however, the low morphine plasma concentrations and high variability produced from this formulation, suggest that the clinical application of this formulation at the doses evaluated inThis study are limited.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: March 2, 2019
2009 journal article
Pharmacokinetics of butorphanol in horses after intramuscular injection
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 32(1), 62–65.
MeSH headings : Absorption; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacokinetics; Animals; Area Under Curve; Biological Availability; Butorphanol / administration & dosage; Butorphanol / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Cross-Over Studies; Female; Half-Life; Heart Rate / drug effects; Horses / blood; Horses / metabolism; Horses / physiology; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Male; Random Allocation
TL;DR:
No significant differences in any physical parameters were observed after butorphanol administration except for an increase in respiratory rate at 60 and 180 min after IV administration, and administration of 0.08 mg/kg IM every 3 h may be necessary to maintain targeted plasmabutorphanol concentrations above 10 ng/mL.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Plasma and ear tissue concentrations of enrofloxacin and its metabolite ciprofloxacin in dogs with chronic end-stage otitis externa after intravenous administration of enrofloxacin
VETERINARY DERMATOLOGY, 20(1), 51–59.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Chronic Disease; Ciprofloxacin / blood; Ciprofloxacin / metabolism; Dog Diseases / drug therapy; Dogs; Dose-Response Relationship, Drug; Ear Canal; Enrofloxacin; Female; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Injections, Intravenous; Male; Otitis Externa / drug therapy; Otitis Externa / veterinary; Skin; Tissue Distribution
TL;DR:
Treating dogs with chronic end-stage otitis undergoing a total ear canal ablation and lateral bulla osteotomy with enrofloxacin would not be recommended for a bacterial organism intermediate or resistant in susceptibility to enro FLX, since appropriate levels of enroFloxac in this study wouldn't be attained.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Single-dose pharmacokinetics and genotoxicity of metronidazole in cats
JOURNAL OF FELINE MEDICINE AND SURGERY, 11(2), 60–68.
MeSH headings : Administration, Oral; Analysis of Variance; Animals; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / toxicity; Cat Diseases / drug therapy; Cats / blood; Cats / genetics; Cats / metabolism; Cell Line, Tumor; Chromatography, High Pressure Liquid / veterinary; Comet Assay / veterinary; DNA / drug effects; Dose-Response Relationship, Drug; Infusions, Intravenous / veterinary; Leukemia Virus, Feline / drug effects; Leukocytes, Mononuclear / drug effects; Metronidazole / blood; Metronidazole / pharmacokinetics; Metronidazole / toxicity; Mutagenicity Tests / veterinary
TL;DR:
Genotoxicity was detected at all concentrations of metronidazole in feline PBMC and the T-cell lymphoma line in vitro and in vivo and observed in PBMC collected from cats after 7 days of oral metronIDazole but resolved within 6 days of discontinuing metronidsazole.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Soy-Derived Isoflavones Inhibit the Growth of Canine Lymphoid Cell Lines
CLINICAL CANCER RESEARCH, 15(4), 1269–1276.
MeSH headings : Animals; Apoptosis / drug effects; Caspase 3 / physiology; Caspase 9 / physiology; Cell Line, Tumor; Cell Proliferation / drug effects; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Genistein / pharmacology; Lymphoma, B-Cell / drug therapy; Lymphoma, B-Cell / pathology; Lymphoma, B-Cell / veterinary; Male; Polysaccharides / pharmacology; Proto-Oncogene Proteins c-bcl-2 / analysis; bcl-2-Associated X Protein / analysis
TL;DR:
The notion that canine high-grade B-cell lymphoma may represent a relevant large animal model of human non-Hodgkin's lymphoma to investigate the utility of GCP in chemopreventive and/or treatment strategies that may serve as a prelude to human clinical lymphoma trials is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 personal communication
Supports compounding standards response
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
What is your diagnosis? Marked hyperchloremia in a dog
VETERINARY CLINICAL PATHOLOGY, 38(3), 411–414.
Contributors: I. Piperisova*, J. Neel* & n
author keywords: Anion gap; bromide; hyperchloremia; interference
MeSH headings : Animals; Bromides / blood; Bromides / toxicity; Chlorides / blood; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Male; Medication Errors / veterinary; Potassium Compounds / blood; Potassium Compounds / toxicity
TL;DR:
This case of extreme bromide toxicity, which apparently resulted from inadvertent use of bromides instead of citrate at the pharmacy, illustrates the importance of knowing common interferents with analyte methodologies and of pursing logical additional diagnostic tests based on clinical and laboratory evidence, when a patient's history appears to rule out a potential etiology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 journal article
An Update on Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Small Animals
Veterinary Clinics of North America: Small Animal Practice, 38(6), 1243–1266.
author keywords: NSAIDs; Anti-inflammatory drugs; Analgesic drugs; Dogs; Cats; Pain; Arthritis; COX-1
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Aspirin / adverse effects; Aspirin / therapeutic use; Cat Diseases / drug therapy; Cats; Dog Diseases / drug therapy; Dogs; Dose-Response Relationship, Drug; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Phenylbutazone / adverse effects; Phenylbutazone / therapeutic use; Species Specificity
TL;DR:
There are several choices of nonsteroidal anti-inflammatory drugs for treating dogs that have osteoarthritis, and veterinarians have the advantage of several approved NSAIDs for which there are excellent published studies and US Food and Drug Administration or foreign approval to guide clinical use and safe dosages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: February 27, 2019
2008 review
An update on nonsteroidal anti-Inflammatory drugs (NSAIDs) in small animals
[Review of ]. Veterinary Clinics of North America. Small Animal Practice, 38(6), 1243-.
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Comparison of the pharmacokinetic properties of bisoprolol and carvedilol in healthy dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 69(12), 1659–1663.
MeSH headings : Administration, Oral; Adrenergic beta-Antagonists / administration & dosage; Adrenergic beta-Antagonists / blood; Adrenergic beta-Antagonists / pharmacokinetics; Animals; Area Under Curve; Biological Availability; Bisoprolol / administration & dosage; Bisoprolol / blood; Bisoprolol / pharmacokinetics; Carbazoles / administration & dosage; Carbazoles / blood; Carbazoles / pharmacokinetics; Carvedilol; Cross-Over Studies; Dogs / metabolism; Half-Life; Injections, Intravenous; Male; Propanolamines / administration & dosage; Propanolamines / blood; Propanolamines / pharmacokinetics
TL;DR:
Differences suggested that, in dogs, bisoprolol has less interindividual pharmacokinetic variability, compared with carvedilol, a third-generation beta1/beta2 and alpha1-adrenoceptor blocking agent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 journal article
Exposure to phenobarbital in a foal after nursing a mare treated with phenobarbital
JOURNAL OF VETERINARY INTERNAL MEDICINE, 22(1), 227–230.
MeSH headings : Animals; Animals, Newborn / blood; Animals, Suckling; Anticonvulsants / adverse effects; Anticonvulsants / blood; Anticonvulsants / pharmacokinetics; Anticonvulsants / therapeutic use; Female; Horse Diseases / drug therapy; Horses; Milk / chemistry; Phenobarbital / adverse effects; Phenobarbital / blood; Phenobarbital / pharmacokinetics; Phenobarbital / therapeutic use; Pregnancy; Pregnancy Complications / drug therapy; Pregnancy Complications / veterinary; Prenatal Exposure Delayed Effects / veterinary; Seizures / drug therapy; Seizures / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 chapter
Guidelines for antimicrobial use in dogs and cats
In L. Guardabassi, L. B. Jensen, & H. Kruse (Eds.), Guide to Antimicrobial Use in Animals. Blackwell Publishing, LTD.
Ed(s): L. Guardabassi, L. Jensen & H. Kruse
Source: NC State University Libraries
Added: April 13, 2019
2008 journal article
Hydroxyzine and cetirizine pharmacokinetics and pharmacodynamics after oral and intravenous administration of hydroxyzine to healthy dogs
VETERINARY DERMATOLOGY, 19(6), 348–357.
Contributors: P. Bizikova*, n & T. Olivry*
MeSH headings : Administration, Oral; Animals; Cetirizine / blood; Cetirizine / metabolism; Cetirizine / pharmacokinetics; Cross-Over Studies; Dogs; Histamine H1 Antagonists / administration & dosage; Histamine H1 Antagonists / pharmacokinetics; Hydroxyzine / administration & dosage; Hydroxyzine / blood; Hydroxyzine / pharmacokinetics; Immunoglobulin E; Injections, Intravenous
TL;DR:
Pharmacokinetic and pharmacodynamic studies evaluated the suppressive effect on histamine and anticanine IgE-mediated cutaneous wheal formation and predicted that maximal antihistamine effect would occur with twice daily oral administration of hydroxyzine at 2 mg kg(-1).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 journal article
Pharmacokinetics and physiological effects of intravenous hydromorphone in conscious dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 31(4), 334–343.
MeSH headings : Analgesia; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacology; Animals; Area Under Curve; Body Temperature / drug effects; Dogs; Dose-Response Relationship, Drug; Female; Half-Life; Hydromorphone / administration & dosage; Hydromorphone / pharmacokinetics; Hydromorphone / pharmacology; Injections, Intravenous; Metabolic Clearance Rate; Models, Biological; Morphine / administration & dosage; Morphine / pharmacokinetics; Receptors, Opioid, mu / antagonists & inhibitors; Respiration / drug effects
TL;DR:
In dogs, intravenous hydromorphone has a large volume of distribution, and high clearance rate that exceeds hepatic blood flow, and in dogs, it produced mechanical anti-nociception and sedation of a magnitude similar to morphine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 article
Pharmacokinetics of Butorphanol and Evaluation of Physiologic and Behavioral Effects after Intravenous and Intramuscular Administration to Neonatal Foals
JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 22, pp. 1417–1426.
author keywords: Drug disposition; Feeding; Narcotic agonist-antagonist; Pedometer; Sedation
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacokinetics; Animals; Animals, Newborn; Behavior, Animal / drug effects; Butorphanol / administration & dosage; Butorphanol / pharmacokinetics; Female; Horses; Injections, Intramuscular; Injections, Intravenous; Male; Time Factors
TL;DR:
The main behavioral effects after butorphanol administration to neonatal foals were sedation and increased feeding behavior.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 journal article
Pharmacokinetics of butorphanol in cats after intramuscular and buccal transmucosal administration
AMERICAN JOURNAL OF VETERINARY RESEARCH, 69(12), 1548–1554.
MeSH headings : Administration, Buccal; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Butorphanol / administration & dosage; Butorphanol / blood; Butorphanol / pharmacokinetics; Cats / metabolism; Cross-Over Studies; Female; Injections, Intramuscular; Male
TL;DR:
In cats, IM butorphanol administration at 0.4 mg/kg maintained a plasma concentration of >45 ng/mL for 2.7+/-2.2 hours, whereas BTM administration at the same dose was not effective at maintaining plasma concentrations at >45 Ng/mL, and extrapolate a plasma concentrations associated with antinociception on the basis of existing data from pharmacologic studies of butorph ethanol in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 journal article
Pharmacokinetics of cetirizine in healty cats
AMERICAN JOURNAL OF VETERINARY RESEARCH, 69(5), 670–674.
MeSH headings : Administration, Oral; Animals; Anti-Allergic Agents / blood; Anti-Allergic Agents / pharmacokinetics; Area Under Curve; Cats / blood; Cats / metabolism; Cetirizine / blood; Cetirizine / pharmacokinetics; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Female; Half-Life; Male
TL;DR:
The half-life of cetirizine in cats is compatible with once-daily dosing, and the extent of protein binding is high.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 journal article
Pharmacokinetics of florfenicol in serum and synovial fluid after regional intravenous perfusion in the distal portion of the hind limb of adult cows
AMERICAN JOURNAL OF VETERINARY RESEARCH, 69(8), 997–1004.
MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Cattle; Female; Hindlimb / metabolism; Infusions, Intravenous; Perfusion / methods; Synovial Fluid / metabolism; Thiamphenicol / analogs & derivatives; Thiamphenicol / blood; Thiamphenicol / pharmacokinetics
TL;DR:
In cattle, RIVP of florfenicol may be useful in the treatment of infectious processes involving the distal portion of limbs in cows following regional IV perfusion (RIVP) of the distals of the hind limb in cows.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 book
Veterinary pharmacology and therapeutics
Ames, IA: Blackwell Publishing.
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
Antibiotic-resistant Corynebacterium jeikeium urinary tract infection in a cat
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 43(1), 61–64.
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacology; Bacteriuria / microbiology; Cat Diseases / drug therapy; Cat Diseases / microbiology; Cats; Corynebacterium / drug effects; Corynebacterium / genetics; Corynebacterium / isolation & purification; Corynebacterium Infections / drug therapy; Corynebacterium Infections / microbiology; Corynebacterium Infections / veterinary; Drug Resistance, Multiple, Bacterial; Enzyme Inhibitors / administration & dosage; Enzyme Inhibitors / pharmacology; Male; Microbial Sensitivity Tests / veterinary; RNA, Ribosomal, 16S / genetics; Treatment Outcome; Urinary Tract Infections / drug therapy; Urinary Tract Infections / microbiology; Urinary Tract Infections / veterinary
TL;DR:
Urine culture and gene sequencing identified Corynebacterium jeikeium, which was resistant to antibiotics and appeared to be the cause of the urinary tract infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 chapter
Antimicrobial Therapy
In Equine Infectious Diseases (pp. 578–591).
Sources: Crossref, ORCID
Added: February 27, 2019
2007 chapter
Blackwell’s Five-Minute Consult Drug Formulary. Appendix IX.
In L. P. Tilley & F. W. K. Smith Jr. (Eds.), Blackwell’s Five Minute Veterinary Consult (Fourth, pp. 1467–1531). Blackwell Publishing.
Ed(s): L. Tilley & F. Smith
Source: NC State University Libraries
Added: April 17, 2019
2007 journal article
Comparison of plasma histamine levels after intravenous administration of hydromorphone and morphine in dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 30(6), 516–522.
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacology; Animals; Behavior, Animal / drug effects; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate / drug effects; Histamine / blood; Hydromorphone / administration & dosage; Hydromorphone / pharmacology; Infusions, Intravenous / veterinary; Morphine / administration & dosage; Morphine / pharmacology
TL;DR:
In conclusion, intravenous hydromorphone induced minimal histamine release and was well tolerated by these conscious healthy dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 chapter
Drug Interactions
In W. J. Tranquilli, J. C. Thurmon, & K. A. Grimm (Eds.), Lumb & Jones' Veterinary Anesthesia and Analgesia (pp. 439–450). Ames, Iowa: Blackwell Publishing.
Ed(s): W. Tranquilli, J. Thurmon & K. Grimm
Source: NC State University Libraries
Added: April 13, 2019
2007 journal article
Efficacy of tinidazole for treatment of cats experimentally infected with Tritrichomonas foetus
AMERICAN JOURNAL OF VETERINARY RESEARCH, 68(10), 1085–1088.
MeSH headings : Animals; Antitrichomonal Agents / therapeutic use; Cat Diseases / drug therapy; Cat Diseases / parasitology; Cats; Dose-Response Relationship, Drug; Protozoan Infections / drug therapy; Tinidazole / therapeutic use; Tritrichomonas foetus / isolation & purification
TL;DR:
Although tinidazole decreased the detection of T foetus and treated cats were resistant to later efforts to incite the infection, inability of tinidrazole to eradicate infection in many cats poses a serious impediment to the drug's effectiveness in practice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 journal article
Naïve averaged, naïve pooled, and population pharmacokinetics of orally administered marbofloxacin in juvenile harbor seals
Journal of the American Veterinary Medical Association, 230(3), 390–395.
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Enzyme Inhibitors / pharmacokinetics; Female; Fluoroquinolones / pharmacokinetics; Male; Metabolic Clearance Rate; Models, Biological; Phoca / blood; Quinolones / pharmacokinetics
TL;DR:
Values of pharmacokinetic variables were similar regardless of the analytic method used and Naïve averaged and naïve pooled analysis appeared to yield a better fit to the population, but nonlinear mixed-effects modeling yielded a betterfit for individual seals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2007 journal article
Performance of the 808-nm diode laser on equine upper airway tissue is enhanced by intravenous administration of indocyanine green
PHOTOMEDICINE AND LASER SURGERY, 25(5), 443–448.
Contributors: L. Tate Jr., A. Blikslager n & n
MeSH headings : Animals; Coloring Agents / administration & dosage; Coloring Agents / pharmacology; Dose-Response Relationship, Drug; Horses; Indocyanine Green / administration & dosage; Indocyanine Green / pharmacology; Injections, Intravenous; Laser Therapy / instrumentation; Laser Therapy / methods; Lasers, Semiconductor; Nasal Mucosa / drug effects; Nasal Mucosa / radiation effects
TL;DR:
It is demonstrated that the 808-nm diode laser, when augmented with intravenous ICG, will be as effective a surgical tool as the Nd:YAG laser on equine upper airway tissues when applied using a non-contact fiber.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 journal article
Pharmacokinetics and pharmacodynamics of morphine in llamas
AMERICAN JOURNAL OF VETERINARY RESEARCH, 68(1), 25–34.
MeSH headings : Analgesia / methods; Analgesia / veterinary; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Analgesics, Opioid / pharmacology; Animals; Body Temperature / drug effects; Camelids, New World / blood; Camelids, New World / metabolism; Cross-Over Studies; Female; Heart Rate / drug effects; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Male; Morphine / blood; Morphine / pharmacokinetics; Morphine / pharmacology; Morphine Derivatives / blood; Random Allocation; Respiration / drug effects
TL;DR:
Morphine was characterized by a large apparent volume of distribution and high systemic clearance in llamas and a prolonged half-life was observed with IM injection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 journal article
Pharmacokinetics and physiological effects of two intravenous infusion rates of morphine in conscious dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 30(3), 224–233.
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Behavior, Animal; Consciousness; Cross-Over Studies; Dogs / metabolism; Female; Infusions, Intravenous / veterinary; Morphine / administration & dosage; Morphine / blood; Morphine / pharmacokinetics; Pain / prevention & control; Pain / veterinary; Pain Measurement / veterinary
TL;DR:
M morphine pharmacokinetics was not altered by increasing infusion rates, producing stable, long-lasting plasma concentrations, and sedation and mechanical antinociception were both mild during the lower infusion rate, and mild to moderate during the higher infusion rate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 journal article
Pharmacokinetics and tissue distribution of enrofloxacin and its active metabolite ciprofloxacin in calves
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 30(6), 564–571.
MeSH headings : Animals; Animals, Newborn / metabolism; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacology; Area Under Curve; Cattle / metabolism; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacology; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / pharmacology; Injections, Subcutaneous / veterinary; Tissue Distribution
TL;DR:
It is concluded that Cmax/MIC and AUC/MIC ratios for free drug concentrations in plasma and ISF would meet suggested ratios for a targeted MIC of 0.06 microg/mL.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 article
Pharmacokinetics of an extended-release theophylline product in cats
Guenther-Yenke, C. L., McKiernan, B. C., Papich, M. G., & Powell, E. (2007, September 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 231, pp. 900–906.
MeSH headings : Administration, Oral; Animals; Area Under Curve; Biological Availability; Bronchodilator Agents / blood; Bronchodilator Agents / pharmacokinetics; Bronchodilator Agents / urine; Capsules; Cats / blood; Cats / metabolism; Cats / urine; Cross-Over Studies; Delayed-Action Preparations; Injections, Intravenous / veterinary; Tablets; Theophylline / blood; Theophylline / pharmacokinetics; Theophylline / urine
TL;DR:
Daily administration of the brand of theophylline tablets and capsules used in this study maintained plasma concentrations within the desired therapeutic range in healthy cats, and these concentrations were within the human therapeutic concentration of 5 to 20 microg/mL.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 journal article
Pharmacokinetics of etodolac in the horse following oral and intravenous administration
Journal of Veterinary Pharmacology and Therapeutics, 30(1), 43–48.
Contributors: J. Davis*, n , A. Morton*, J. Gayle*, A. Blikslager* & N. Campbell n
MeSH headings : Administration, Oral; Animals; Area Under Curve; Cross-Over Studies; Cyclooxygenase 1 / drug effects; Cyclooxygenase 2 / drug effects; Cyclooxygenase Inhibitors / administration & dosage; Cyclooxygenase Inhibitors / blood; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / pharmacology; Etodolac / administration & dosage; Etodolac / blood; Etodolac / pharmacokinetics; Etodolac / pharmacology; Female; Horses / metabolism; Injections, Intravenous / veterinary; Male
TL;DR:
It was showed that etodolac is well absorbed in the horse after oral administration, and may offer a useful alternative for anti-inflammatory treatment of various conditions in thehorse.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2007 article
Pharmacokinetics of metronidazole in the red-eared slider turtle (Trachemys scripta elegans) after single intracoelomic injection
Innis, C., Papich, M., & Young, D. (2007, April). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 30, pp. 168–171.
MeSH headings : Animal Structures; Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / blood; Antiprotozoal Agents / pharmacokinetics; Injections / veterinary; Metronidazole / administration & dosage; Metronidazole / blood; Metronidazole / pharmacokinetics; Turtles / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 book
Saunders Handbook of Veterinary Drugs
(Second). St. Louis, Missouri: Saunders Elsevier.
Source: NC State University Libraries
Added: March 29, 2019
2007 book
Saunders handbook of veterinary drugs. (2nd ed.)
St. Louis, Mo.: Saunders Elsevier.
Source: NC State University Libraries
Added: August 6, 2018
2007 article
Use of basal serum or plasma cortisol concentrations to rule out a diagnosis of hypoadrenocorticism in dogs: 123 cases (2000-2005)
Lennon, E. M., Boyle, T. E., Hutchins, R. G., Friedenthal, A., Correa, M. T., Bissett, S. A., … Birkenheuer, A. J. (2007, August 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 231, pp. 413–416.
MeSH headings : Adrenal Glands / pathology; Adrenal Insufficiency / blood; Adrenal Insufficiency / diagnosis; Adrenal Insufficiency / genetics; Adrenal Insufficiency / veterinary; Animals; Case-Control Studies; Diagnosis, Differential; Dog Diseases / blood; Dog Diseases / diagnosis; Dog Diseases / genetics; Dogs; Female; Genetic Predisposition to Disease; Hydrocortisone / blood; Male; Nova Scotia / epidemiology; Pedigree; Predictive Value of Tests; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2006 journal article
Bone marrow hypoplasia secondary to florfenicol toxicity in a Thomson's gazelle (Gazella thomsonii)
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 29(4), 317–319.
MeSH headings : Abscess / drug therapy; Abscess / veterinary; Animals; Animals, Zoo; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / adverse effects; Blood Platelet Disorders / chemically induced; Blood Platelet Disorders / veterinary; Diagnosis, Differential; Injections, Subcutaneous / veterinary; Male; Mandibular Diseases / drug therapy; Mandibular Diseases / veterinary; Ruminants; Thiamphenicol / administration & dosage; Thiamphenicol / adverse effects; Thiamphenicol / analogs & derivatives
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2006 chapter
Drug Therapy in Cats: Precautions and Guidelines
In Consultations in Feline Internal Medicine (pp. 279–290).
Sources: Crossref, ORCID
Added: February 27, 2019
2006 article
Efficacy of ronidazole for treatment of feline Tritrichomonas foetus infection
JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 20, pp. 536–543.
author keywords: colitis; diarrhea; metronidazole; nitroimidazole; tinidazole
TL;DR:
Oral administration of RDZ at 30 to 50 mg/kg PO q12h for 14 days resolved diarrhea and eradicated infection in 1 naturally infected cat and 10 experimentally inoculated cats receiving a different isolate of T foetus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2006 journal article
Evaluation of an implanted osmotic pump for delivery of amikacin to corn snakes (Elaphe guttata guttata)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 37(3), 373–380.
author keywords: alzet((R)) osmotic pump; amikacin; renal scintigraphy; hypercalcemia; hyperphosphatemia; pharmacokinetics; Elaphe guttata; snake
MeSH headings : Amikacin / administration & dosage; Amikacin / blood; Amikacin / pharmacokinetics; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Drug Administration Routes / veterinary; Drug Delivery Systems / methods; Drug Delivery Systems / veterinary; Female; Infusion Pumps, Implantable / veterinary; Injections, Intramuscular / veterinary; Kidney / diagnostic imaging; Kidney / metabolism; Kidney / physiology; Male; Predictive Value of Tests; Radionuclide Imaging; Snakes / blood; Snakes / metabolism
TL;DR:
Osmotic pumps loaded with amikacin were surgically placed into the coelomic cavity of five adult corn snakes and were efficacious in achieving a constant plasma concentration of amikACin at the predicted level.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2006 journal article
Mucosal permeability of water-soluble drugs in the equine jejunum: a preliminary investigation
Journal of Veterinary Pharmacology and Therapeutics, 29(5), 379–385.
Contributors: J. Davis*, D. Little n, A. Blikslager n & *
MeSH headings : Animals; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / pharmacology; Biological Availability; Cephalexin / chemistry; Cephalexin / pharmacokinetics; Fluconazole / chemistry; Fluconazole / pharmacokinetics; Fluoroquinolones / chemistry; Fluoroquinolones / pharmacokinetics; Horses; Intestinal Mucosa / drug effects; Jejunum / metabolism; Linear Models; Metronidazole / chemistry; Metronidazole / pharmacokinetics; Permeability / drug effects; Quinolones / chemistry; Quinolones / pharmacokinetics; Solubility
TL;DR:
The Ussing chamber is a promising method for determining mucosal permeability in the horse and the low permeability of cephalexin across the tissue may indicate a lack of active transporters that are found in other species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2006 journal article
Pharmacokinetics and tissue distribution of doxycycline after oral administration of single and multiple doses in horses
AMERICAN JOURNAL OF VETERINARY RESEARCH, 67(2), 310–316.
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Doxycycline / administration & dosage; Doxycycline / blood; Doxycycline / pharmacokinetics; Drug Administration Schedule; Female; Food Deprivation; Half-Life; Horses / metabolism; Male; Tissue Distribution
TL;DR:
Results suggest that doxycycline administered at a dosage of 20 mg/kg, PO, every 24 hours will result in drug concentrations adequate for killing intracellular bacteria and bacteria with minimum inhibitory concentration < or = 0.25 microg/mL.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2006 journal article
Pharmacokinetics of florfenicol after a single intramuscular dose in white-spotted bamboo sharks (Chiloscyllium plagiosum)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 37(2), 165–173.
author keywords: bamboo shark; Chiloscyllium plagiosum; florfenicol; pharmacokinetics; meningitis
MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / cerebrospinal fluid; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Dose-Response Relationship, Drug; Female; Half-Life; Injections, Intramuscular / veterinary; Male; Meningitis, Bacterial / drug therapy; Meningitis, Bacterial / veterinary; Microbial Sensitivity Tests / veterinary; Pilot Projects; Sharks / blood; Sharks / metabolism; Thiamphenicol / analogs & derivatives; Thiamphenicol / blood; Thiamphenicol / cerebrospinal fluid; Thiamphenicol / pharmacokinetics
TL;DR:
The pharmacokinetics of florfenicol in the white-spotted bamboo shark was evaluated and the potential application for treatment of bacterial meningitis was explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2006 journal article
Pharmacokinetics of fluconazole after oral administration of single and multiple doses in African grey parrots
AMERICAN JOURNAL OF VETERINARY RESEARCH, 67(3), 417–422.
MeSH headings : Absorption; Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Area Under Curve; Dose-Response Relationship, Drug; Fluconazole / administration & dosage; Fluconazole / blood; Fluconazole / pharmacokinetics; Half-Life; Parrots / metabolism; Suspensions; Tablets
TL;DR:
Oral administration of fluconazole to parrots at 10 to 20 mg/kg every 24 to 48 hours maintains plasma concentrations above the minimum inhibitory concentration for several common yeast species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2006 journal article
Pharmacokinetics of ketoprofen in the green iguana (Iguana iguana) following single intravenous and intramuscular injections
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 37(4), 567–570.
author keywords: analgesia; green iguana (Iguana iguana); ketoprofen; pharrnacokinetics; NSAID; reptile
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Cyclooxygenase Inhibitors / pharmacokinetics; Female; Half-Life; Iguanas / blood; Iguanas / metabolism; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Ketoprofen / pharmacokinetics; Male; Metabolic Clearance Rate; Random Allocation
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2006 journal article
Pharmacokinetics of voriconazole after oral and intravenous administration to horses
AMERICAN JOURNAL OF VETERINARY RESEARCH, 67(6), 1070–1075.
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Biological Availability; Chemistry, Pharmaceutical; Cross-Over Studies; Drug Stability; Female; Horses / blood; Injections, Intravenous; Male; Pyrimidines / administration & dosage; Pyrimidines / blood; Pyrimidines / pharmacokinetics; Triazoles / administration & dosage; Triazoles / blood; Triazoles / pharmacokinetics; Voriconazole
TL;DR:
It was concluded that administration of voriconazole at a dosage of 4 mg/kg, PO, every 24 hours will attain plasma concentrations adequate for treatment of horses with fungal infections for which the fungi have a minimum inhibitory concentration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2006 journal article
Single-dose intravenous and oral pharmacokinetics of enrofloxacin in goral (Nemorrhaedus goral arnouxianus)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 37(2), 145–150.
author keywords: pharmacokinetics; enrofloxacin; ciprofloxacin; goral; Nemorrhaedus goral; antibiotic
MeSH headings : Administration, Oral; Animals; Animals, Wild; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Cross-Over Studies; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / pharmacokinetics; Half-Life; Injections, Intravenous / veterinary; Male; Ruminants / blood; Ruminants / metabolism
TL;DR:
Oral enrofloxacin may be considered for further study as a treatment option for susceptible infections in goral and an area under the plasma concentration over time curve to minimum inhibitory concentration ratio > 100 for many gram-positive and gram-negative bacterial pathogens common to small ruminants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2006 journal article
The pharmacokinetics of orbifloxacin in the horse following oral and intravenous administration
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 29(3), 191–197.
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Ciprofloxacin / administration & dosage; Ciprofloxacin / analogs & derivatives; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Cross-Over Studies; Drug Administration Schedule; Female; Horses / metabolism; Infusions, Intravenous / veterinary; Male; Protein Binding
TL;DR:
This dose is suggested for further studies on the clinical efficacy of orbifloxacin for treatment of susceptible bacterial infections in the horse, an oral dose of approximately 5 mg/kg once daily will produce plasma concentrations within the suggested range.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 chapter
Antimicrobial Drug Therapy
In S. J. Ettinger & E. C. Feldman (Eds.), Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat (6th ed., pp. 498–502). St. Louis, Missouri: Elsevier Saunders.
Ed(s): S. Ettinger & E. Feldman
Source: NC State University Libraries
Added: April 17, 2019
2005 journal article
Antimicrobial drug use in veterinary medicine
JOURNAL OF VETERINARY INTERNAL MEDICINE, 19(4), 617–629.
author keywords: antibacterial; antibiotic; prudent use; resistance
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 journal article
Assessment of a von Frey device for evaluation of the antinociceptive effects of morphine and its application in pharmacodynamic modeling of morphine in dogs
American Journal of Veterinary Research, 66(9), 1616–1622.
MeSH headings : Analgesics / therapeutic use; Animals; Chromatography, High Pressure Liquid / veterinary; Dogs / metabolism; Drug Design; Evaluation Studies as Topic; Morphine / blood; Morphine / therapeutic use; Pain / drug therapy; Pain Measurement / instrumentation; Pain Measurement / methods; Pain Measurement / veterinary; Statistics, Nonparametric
TL;DR:
Data suggest that, in dogs, evaluation of the antinociceptive effect and pharmacodynamic modeling of a dose of morphine sulfate (1 mg/kg, i.v.) can be successfully achieved by use of a von Frey device.
(via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2005 journal article
Assessment of plasma concentrations and effects of injectable doxycycline in three psittacine species
JOURNAL OF AVIAN MEDICINE AND SURGERY, 19(3), 216–224.
author keywords: Chlamydia; Chlamydophila psittaci; avian chlamydiosis; psittacosis; doxycycline; pharmacist compounded; avian; Psittaciformes
TL;DR:
The results of this study show that both the efficacy and the severity of injection-site reactions seen with use of this particular formulation of pharmacist-compounded doxycycline may vary depending on the species treated and particular drug batch.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 review
Drug compounding for veterinary patients
[Review of ]. AAPS Journal, 7(2).
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Drug compounding for veterinary patients
AAPS Journal (American Association of Pharmaceutical Scientists), 7(2), E281–287.
Source: NC State University Libraries
Added: April 13, 2019
2005 journal article
Enrofloxacin pharmacokinetics in the European cuttlefish, Sepia officinalis, after a single i.v. injection and bath administration
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 28(5), 433–439.
MeSH headings : Administration, Cutaneous; Administration, Oral; Animals; Area Under Curve; Bacteria / drug effects; Decapodiformes / metabolism; Decapodiformes / microbiology; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Fluoroquinolones / pharmacology; Immersion; Injections, Intravenous / veterinary; Microbial Sensitivity Tests
TL;DR:
The hemolymph concentration was still above minimum inhibitory concentration values for shrimp and fish bacterial isolates at 6 h after i.v. administration, so a bath of 2.5 mg/L for 5 h once to twice daily is suggested for additional studies to test efficacy against highly susceptible organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 journal article
Evaluation of a method of intracoelomic catheterization in koi
Journal of the American Veterinary Medical Association, 226(5), 784–788.
MeSH headings : Animals; Carps; Catheterization / adverse effects; Catheterization / methods; Catheterization / veterinary; Catheters, Indwelling / adverse effects; Catheters, Indwelling / veterinary; Drug Administration Routes / veterinary; Enrofloxacin; Fluoroquinolones / pharmacokinetics; Prospective Studies; Quinolones / pharmacokinetics; Safety
TL;DR:
An intracoelomic catheter was effective and safe when maintained in koi for at least 6 days and would be highly beneficial for veterinarians, clients, and fish, especially when intracoELomic administration of a drug would require daily or more frequent dosing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2005 journal article
Evaluation of transdermal application of glipizide in a pluronic lecithin gel to healthy cats
AMERICAN JOURNAL OF VETERINARY RESEARCH, 66(4), 581–588.
MeSH headings : Administration, Cutaneous; Administration, Oral; Animals; Blood Glucose / metabolism; Cats / blood; Excipients / administration & dosage; Excipients / pharmacokinetics; Female; Glipizide / administration & dosage; Glipizide / blood; Glipizide / pharmacokinetics; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / blood; Hypoglycemic Agents / pharmacokinetics; Insulin / blood; Male; Phosphatidylcholines / administration & dosage; Phosphatidylcholines / pharmacokinetics; Poloxamer / administration & dosage; Poloxamer / pharmacokinetics; Random Allocation
TL;DR:
Transdermal absorption of glipizide was low and inconsistent, but analysis of the results indicated that it did affect plasma glucose concentrations, and transdermal administration of gl ipizide cannot be recommended for clinical use at this time.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 journal article
Pharmacokinetics after intravenous, subcutaneous, and oral administration of enrofloxacin to alpacas
American Journal of Veterinary Research, 66(5), 767–771.
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Camelids, New World / metabolism; Enrofloxacin; Female; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Half-Life; Injections, Intravenous / veterinary; Injections, Subcutaneous / veterinary; Quinolones / administration & dosage; Quinolones / blood; Quinolones / pharmacokinetics
TL;DR:
The administration of enrofloxacin (5 mg/kg, s.c. and p.o) may be appropriate for antimicrobial treatment of alpacas and yielded a ratio for AUC to minimum inhibitory concentration > 100 for many grampositive and gram-negative bacterial pathogens common to camelids.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2005 journal article
Pharmacokinetics and Safety of Acyclovir in Tragopans (Tragopan species)
Journal of Avian Medicine and Surgery, 19(4), 271–276.
author keywords: herpesvirus; acyclovir; pharmacokinetics; avian; pheasants; tragopans; Tragopan; species
TL;DR:
Results from this study suggest that a dosage of 120 mg/kg PO q12h in tragopans may achieve effective plasma concentrations (1.0 μg/ml) for potential treatment and prevention of herpesviral infections, however, further studies are needed to determine if this dosage is safe for repeated administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018
2005 article
Pharmacokinetics and tissue distribution of itraconazole after oral and intravenous administration to horses
Davis, J. L., Salmon, J. H., & Papich, M. G. (2005, October). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 66, pp. 1694–1701.
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Horses / metabolism; Injections, Intravenous / veterinary; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics; Protein Binding
TL;DR:
Itraconazole administered orally as a solution had higher, more consistent absorption than orally administered capsules and attained plasma concentrations that are inhibitory against fungi that infect horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 journal article
Pharmacokinetics and tissue fluid distribution of cephalexin in the horse after oral and i.v. administration
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 28(5), 425–431.
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Cephalexin / administration & dosage; Cephalexin / blood; Cephalexin / pharmacokinetics; Cross-Over Studies; Female; Horses / metabolism; Injections, Intravenous / veterinary; Male; Tissue Distribution
TL;DR:
This study showed that cephalexin at a dose of 30 mg/kg administered orally at 8 h dosage intervals in horses can produce plasma and interstitial fluid drug concentrations that are in a range recommended to treat susceptible gram-positive bacteria (MIC < or = 0.5 microg/mL).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 journal article
Pharmacokinetics of a single dose of enrofloxacin administered orally to captive Asian elephants (Elephas maximus)
AMERICAN JOURNAL OF VETERINARY RESEARCH, 66(11), 1948–1953.
MeSH headings : Administration, Oral; Animal Feed; Animals; Animals, Zoo; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Elephants / metabolism; Enrofloxacin; Female; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Half-Life
TL;DR:
Analysis of results suggests that enrofloxacin administered with feed in the manner described in this study could be a potentially useful antimicrobial for use in treatment of captive Asian elephants with infections attributable to organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 journal article
Pharmacokinetics of acyclovir in adult horses
Journal of Veterinary Emergency and Critical Care, 15(3), 174–178.
author keywords: abortion; central nervous system; equine; herpes; respiratory
TL;DR:
IV administration of acyclovir to healthy adult horses achieves concentrations within the sensitivity range described for equine herpes virus-type 1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: March 2, 2019
2005 journal article
Pharmacokinetics of florfenicol in the red pacu (Piaractus brachypomus) after single dose intramuscular administration
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 28(3), 317–319.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Drug Administration Schedule; Fishes / metabolism; Injections, Intramuscular / veterinary; Thiamphenicol / administration & dosage; Thiamphenicol / analogs & derivatives; Thiamphenicol / blood; Thiamphenicol / pharmacokinetics
TL;DR:
The objectives of this study were to determine the maximum serum concentrations, elimination half-life, and relative bioavailability of florfenicol in the red pacu following single-dose intramuscular (i.m.) administration and reversephase high performance liquid chromatography (HPLC).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 journal article
Pharmacokinetics of morphine and plasma concentrations of morphine-6-glucuronide following morphine administration to dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 28(4), 371–376.
MeSH headings : Administration, Oral; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Cross-Over Studies; Delayed-Action Preparations; Dogs / metabolism; Female; Injections, Intravenous / veterinary; Male; Morphine / administration & dosage; Morphine / blood; Morphine / pharmacokinetics; Morphine Derivatives / blood
TL;DR:
Computer simulations concluded morphine sulfate administered 0.5 mg/kg intravenously every 2 h would maintain morphine plasma concentrations consistent with analgesic plasma concentrations in humans and oral morphine is poorly and erratically absorbed in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 journal article
Pharmacokinetics of oral omeprazole in llamas
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 28(6), 539–543.
MeSH headings : Administration, Oral; Animals; Anti-Ulcer Agents / administration & dosage; Anti-Ulcer Agents / blood; Anti-Ulcer Agents / pharmacokinetics; Area Under Curve; Camelids, New World / metabolism; Female; Omeprazole / administration & dosage; Omeprazole / blood; Omeprazole / pharmacokinetics
TL;DR:
Oral omeprazole produced plasma drug concentrations which are not likely to be associated with clinical efficacy in camelids, and due to low absorption the oral dose was increased to 8 and 12 mg/kg and studies were repeated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 journal article
Plasma and interstitial fluid pharmacokinetics of enrofloxacin, its metabolite ciprofloxacin, and marbofloxacin after oral administration and a constant rate intravenous infusion in dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 28(4), 329–341.
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Cross-Over Studies; Dogs / metabolism; Enrofloxacin; Extracellular Fluid / metabolism; Female; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Infusions, Intravenous / veterinary; Quinolones / administration & dosage; Quinolones / blood; Quinolones / pharmacokinetics
TL;DR:
The ISF and plasma-unbound concentrations were similar during the steady-state period despite differences in lipophilicity and pharmacokinetic parameters of the drugs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 journal article
The effects of inhibiting cytochrome P450 3A, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 28(5), 461–466.
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / drug effects; Administration, Oral; Animals; Area Under Curve; Biological Availability; Cross-Over Studies; Cytochrome P-450 CYP3A / drug effects; Cytochrome P-450 CYP3A Inhibitors; Dogs / metabolism; Enzyme Inhibitors / administration & dosage; Enzyme Inhibitors / pharmacology; Female; Gastric Acid / metabolism; Injections, Intravenous / veterinary; Ketoconazole / administration & dosage; Ketoconazole / pharmacology; Male; Methadone / administration & dosage; Methadone / blood; Methadone / pharmacokinetics; Omeprazole / administration & dosage; Omeprazole / pharmacology; Proton Pump Inhibitors
TL;DR:
In contrast to its pharmacokinetics humans, methadone has a short elimination half-life, rapid clearance, and low oral bioavailability in dogs and the extent of absorption is not affected by inhibition of CYP3A, p-gp, and gastric acid secretion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 article
Use of a von Frey device for evaluation of pharmacokinetics and pharmacodynamics of morphine after intravenous administration as an infusion or multiple doses in dogs
KuKanich, B., Lascelles, B. D. X., & Papich, M. G. (2005, November). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 66, pp. 1968–1974.
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Analgesics, Opioid / pharmacology; Animals; Area Under Curve; Cross-Over Studies; Dogs / blood; Female; Half-Life; Hematocrit / veterinary; Infusions, Intravenous / veterinary; Injections, Intravenous / veterinary; Male; Morphine / administration & dosage; Morphine / blood; Morphine / pharmacokinetics; Morphine / pharmacology; Pain Measurement / veterinary; Random Allocation; Statistics, Nonparametric
TL;DR:
Evaluating the pharmacokinetics and pharmacodynamics of morphine after IV administration as an infusion or multiple doses in dogs by use of a von Frey (vF) device maintained significant antinociception in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 journal article
Validation of a high-pressure liquid chromatography and fluorescence polarization immunoassay for the determination of methadone in canine plasma
THERAPEUTIC DRUG MONITORING, 27(3), 389–392.
author keywords: HPLC; FPIA; dog; concentration
MeSH headings : Animals; Chromatography, High Pressure Liquid / methods; Dogs; Female; Fluorescence Polarization Immunoassay / methods; Male; Methadone / blood
TL;DR:
FPIA provides a rapid, sensitive, and specific measurement of methadone in canine plasma following oral and intravenous administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 chapter
Veterinary Pharmaceuticals: Factors Influencing their Development and Use
In Encyclopedia of Pharmaceutical Technology. Taylor & Francis.
Source: NC State University Libraries
Added: April 13, 2019
2004 journal article
Allometric analysis of ciprofloxacin and enrofloxacin pharmacokinetics across species
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 27(3), 139–146.
MeSH headings : Animals; Anti-Infective Agents / pharmacokinetics; Ciprofloxacin / pharmacokinetics; Enrofloxacin; Fluoroquinolones / pharmacokinetics; Humans; Models, Biological; Quinolones / pharmacokinetics; Species Specificity; Veterinary Drugs / pharmacokinetics
TL;DR:
Results of the current analyses indicate it is possible to use allometry to predict pharmacokinetic variables of enrofloxacin or ciprofl oxacin based on body size of species, which could provide information on appropriate doses of ciprafloxACin and enro FLX for all species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 book
Cephalosporins in veterinary medicine
Parsippany-Troy Hills, NJ: Pfizer Animal Health.
Source: NC State University Libraries
Added: February 5, 2022
2004 journal article
Characterization of the Pharmacokinetic and Pharmacodynamic Properties of the Angiotensin-Converting Enzyme Inhibitor, Enalapril, in Horses
Journal of Veterinary Internal Medicine, 18(2), 231–237.
TL;DR:
There was a tendency (P = .0625) toward a decrease in ACE activity 45-120 minutes after enalapril administration, but ACE activity suppression was never > 16%.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Comparison of amikacin pharmacokinetics in a killer whale (Orcinus orca) and a beluga whale (Delphinapterus leucas)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 35(2), 179–184.
author keywords: aminoglycoside; amikacin; Delphinapterus leucas; pharmacokinetics; whale; Orcinus orca
MeSH headings : Amikacin / adverse effects; Amikacin / pharmacokinetics; Animals; Anti-Bacterial Agents / adverse effects; Anti-Bacterial Agents / pharmacokinetics; Dolphins / metabolism; Dose-Response Relationship, Drug; Female; Gram-Negative Bacterial Infections / drug therapy; Gram-Negative Bacterial Infections / veterinary; Half-Life; Injections, Intramuscular / veterinary; Metabolic Clearance Rate; Microbial Sensitivity Tests; Treatment Outcome; Whales / metabolism
TL;DR:
Both whales exhibited a prolonged elimination half-life and decreased clearance when compared with other animal species despite normal renal parameters on biochemistry panels, and allometric principles and therapeutic drug monitoring were used to accurately determine the doses and to avoid toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 chapter
Drug therapy for diseases of the central nervous system
In S. R. Platt & N. J. Olby (Eds.), BSAVA Manual of Canine and Feline Neurology (pp. 368–384). Quedgeley, Gloucester, England: British Small Animal Veterinary Association.
Ed(s): S. Platt & N. Olby
Source: NC State University Libraries
Added: June 8, 2019
2004 article
Effects of continuous rate intravenous infusion of butorphanol on physiologic and outcome variables in horses after celiotomy
JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 18, pp. 555–563.
author keywords: behavior; colic; cortisol; pain management; stress
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Enrofloxacin and ciprofloxacin plasma concentrations in sandhill cranes (Grus canadensis) after enrofloxacin administration in drinking water
JOURNAL OF AVIAN MEDICINE AND SURGERY, 18(3), 144–150.
author keywords: enrofloxacin; ciprofloxacin; water medication; avian; sandhill cranes; Grus canadensis
TL;DR:
Based on the plasma concentrations achieved in this preliminary study and the minimum inhibitory concentration values for bacteria commonly isolated from poultry species, enrofloxacin-medicated water would only be effective for treating infections of highly susceptible bacteria in sandhill cranes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 article
Evaluation of the bioavailability and pharmacokinetics of two extended-release theophylline formulations in dogs
Bach, J. F., Kukanich, B., Papich, M. G., & McKiernan, B. C. (2004, April 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 224, pp. 1113–1119.
MeSH headings : Administration, Oral; Animals; Biological Availability; Bronchodilator Agents / administration & dosage; Bronchodilator Agents / blood; Bronchodilator Agents / pharmacokinetics; Capsules; Computer Simulation; Cross-Over Studies; Delayed-Action Preparations; Dogs / blood; Dogs / metabolism; Drug Administration Schedule / veterinary; Female; Half-Life; Injections, Intravenous / veterinary; Male; Random Allocation; Tablets; Theophylline / administration & dosage; Theophylline / blood; Theophylline / pharmacokinetics
TL;DR:
Results of these single-dose studies indicated that administration of the specific brand of extended-release theophylline tablets or capsules used in this study at a dosage of 10 mg x kg(-1), PO, every 12 hours would maintain plasma concentrations within the desired therapeutic range in healthy dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Moxifloxacin pharmacokinetics in horses and disposition into phagocytes after oral dosing
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 27(1), 57–60.
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Aza Compounds / administration & dosage; Aza Compounds / blood; Aza Compounds / pharmacokinetics; Female; Fluoroquinolones; Horses / metabolism; Moxifloxacin; Phagocytes / metabolism; Quinolines / administration & dosage; Quinolines / blood; Quinolines / pharmacokinetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 article
Pharmackokinetics of enrofloxacin in neonatal kittens
Seguin, M. A., Papich, M. G., Sigle, K. J., Gibson, N. M., & Levy, J. K. (2004, March). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 65, pp. 350–356.
MeSH headings : Administration, Oral; Age Factors; Animals; Cats / metabolism; Ciprofloxacin / blood; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Injections, Subcutaneous / veterinary; Quinolones / administration & dosage; Quinolones / blood; Quinolones / pharmacokinetics; Time Factors
TL;DR:
Doses may need to be increased to achieve therapeutic drug concentrations in 6- to 8-week-old kittens and oral administration of enrofloxacin resulted in poor bioavailability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Pharmacokinetic disposition of a long-acting oxytetracycline formulation after single-dose intravenous and intramuscular administrations in the American alligator (Alligator mississippiensis)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 35(3), 341–346.
author keywords: American alligator; Alligator mississippiensis; pharmacokinetics; long-acting oxytetracycline; parenteral; antibiotic
MeSH headings : Alligators and Crocodiles / blood; Alligators and Crocodiles / metabolism; Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Metabolic Clearance Rate; Oxytetracycline / administration & dosage; Oxytetracycline / blood; Oxytetracycline / pharmacokinetics
TL;DR:
Based on the results of this study, long-acting preparations of oxytetracycline administered parenterally to American alligators at 10 mg/kg q 5 days is expected to maintain plasma concentrations above the minimum inhibitory concentration of 4.0 μg/ml for susceptible organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Pharmacokinetics and pharmacodynamics of furosemide after oral administration to horses
JOURNAL OF VETERINARY INTERNAL MEDICINE, 18(5), 739–743.
author keywords: equine; frusemide; loop diuretic; oral bioavailability
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Pharmacokinetics of enrofloxacin after single-dose oral and intravenous administration in the American alligator (Alligator mississippiensis)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 35(3), 333–340.
author keywords: American alligator; Alligator mississippiensis; pharmacokinetics; enrofloxacin; ciprofloxacin; oral; antibiotic
MeSH headings : Administration, Oral; Alligators and Crocodiles / blood; Alligators and Crocodiles / metabolism; Animals; Animals, Wild / metabolism; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / pharmacokinetics; Injections, Intravenous / veterinary; Microbial Sensitivity Tests / veterinary; Quinolones / administration & dosage; Quinolones / pharmacokinetics; Random Allocation
TL;DR:
Enrofloxacin administered to American alligators at 5 mg/kg p.o.v. is expected to maintain plasma concentrations that approximate the minimum inhibitory concentration for susceptible organisms (0.5 μg/ml).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Pharmacokinetics of oxytetracycline in loggerhead sea turtles (Caretta caretta) after single intravenous and intramuscular injections
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 35(4), 477–488.
author keywords: biologic marker; Caretta caretta; loggerhead sea turtle; oxytetracycline; pharmacokinetics
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Cross-Over Studies; Half-Life; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Metabolic Clearance Rate; Oxytetracycline / administration & dosage; Oxytetracycline / pharmacokinetics; Turtles / blood; Turtles / metabolism
TL;DR:
The pharmacokinetics of oxytetracycline in 2-yr-old loggerhead sea turtles (Caretta caretta) after single i.v. and i.m. injections indicates that an infrequent dosing interval may be effective for sensitive bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Pharmacokinetics of tramadol and the metabolite O-desmethyl tramadol in dogs
Journal of Veterinary Pharmacology and Therapeutics, 27(4), 1–8.
MeSH headings : Administration, Oral; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacokinetics; Animals; Area Under Curve; Cross-Over Studies; Dogs / metabolism; Female; Injections, Intravenous / veterinary; Male; Tramadol / administration & dosage; Tramadol / analogs & derivatives; Tramadol / pharmacokinetics
TL;DR:
Simulated oral dosing regimens predict tramadol and M1 plasma concentrations consistent with analgesia in humans; however, studies are needed to establish the safety and efficacy of these doses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Plasma profile and pharmacokinetics of dextromethorphan after intravenous and oral administration in healthy dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 27(5), 337–341.
MeSH headings : Administration, Oral; Animals; Antitussive Agents / administration & dosage; Antitussive Agents / blood; Antitussive Agents / pharmacokinetics; Antitussive Agents / pharmacology; Area Under Curve; Biological Availability; Cross-Over Studies; Dextromethorphan / administration & dosage; Dextromethorphan / blood; Dextromethorphan / pharmacokinetics; Dextromethorphan / pharmacology; Dextrorphan / blood; Dogs / metabolism; Female; Injections, Intravenous / veterinary; Male; Muscle, Skeletal / drug effects; Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
TL;DR:
The short half-life, rapid clearance, and poor bioavailability of dextromethorphan limit its potential use as a chronic orally administered therapeutic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
The relationship between susceptibility testing and efficacy
NAVC Clinician’s Brief, 45–47.
Source: NC State University Libraries
Added: April 13, 2019
2004 journal article
Veterinary application of in vitro dissolution data and the Biopharmaceutics Classification System
Stimuli to the Revision Process. Pharmacopeial Forum (United States Pharmacopeial Convention), 30(6), 2–10.
Source: NC State University Libraries
Added: August 6, 2018
2003 chapter
Antimicrobial Therapy for Horses
In Current Therapy in Equine Medicine (pp. 6–11).
Sources: Crossref, ORCID
Added: February 27, 2019
2003 journal article
Antimicrobial therapy for gastrointestinal diseases
Veterinary Clinics of North America: Equine Practice, 19(3), 645–663.
MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Anti-Bacterial Agents / therapeutic use; Bacterial Infections / chemically induced; Bacterial Infections / microbiology; Bacterial Infections / veterinary; Colic / chemically induced; Colic / microbiology; Colic / veterinary; Diarrhea / chemically induced; Diarrhea / microbiology; Diarrhea / veterinary; Drug Resistance, Bacterial; Gastrointestinal Diseases / chemically induced; Gastrointestinal Diseases / microbiology; Gastrointestinal Diseases / veterinary; Horse Diseases / chemically induced; Horse Diseases / microbiology; Horses; Intestinal Absorption; Intestines / microbiology; Kinetics
TL;DR:
There is justification for antibiotic therapy for the conditions described in this article and disruption of the endogenous bacterial population, colitis, and diarrhea are the most common complications from antibiotic therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2003 article
Assessment of plasma concentrations of doxycycline in budgerigars fed medicated seed or water
Flammer, K., Trogdon, M. M., & Papich, M. (2003, October 1). JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 223, pp. 993–998.
MeSH headings : Animal Feed; Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Bird Diseases / drug therapy; Chlamydophila Infections / drug therapy; Chlamydophila Infections / veterinary; Dose-Response Relationship, Drug; Doxycycline / blood; Doxycycline / pharmacokinetics; Doxycycline / therapeutic use; Female; Male; Parrots / blood; Prospective Studies
TL;DR:
Results suggest that hulled seed containing 300 mg of doxycycline hyclate/kg can safely establish and maintain plasma doxy cycline concentrations that are considered adequate for treatment of chlamydiosis in adult nonbreeding budgerigars.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2003 journal article
Comparison of Injectable Versus Oral Enrofloxacin Pharmacokinetics in Red-Eared Slider Thirties, Trachemys scripta elegans
Journal of Herpetological Medicine and Surgery, 13(1), 5–10.
TL;DR:
Three male and three female red-eared slider turtles, Trachemys scripta elegans, were given an intramuscular injection of enrofloxacin (5 mg/kg body weight) and after a period of six weeks, the same animals were given oral doses of en rofloxACin (10 mg/ kg body weight).
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: March 2, 2019
2003 journal article
Comparison of plasma and interstitial fluid concentrations of doxycycline and meropenem following constant rate intravenous infusion in dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 64(8), 1040–1046.
MeSH headings : Animals; Area Under Curve; Cross-Over Studies; Dogs / blood; Dogs / metabolism; Doxycycline / administration & dosage; Doxycycline / blood; Doxycycline / pharmacokinetics; Extracellular Space; Female; Half-Life; Injections, Intravenous; Male; Meropenem; Protein Binding; Thienamycins / administration & dosage; Thienamycins / blood; Thienamycins / pharmacokinetics
TL;DR:
The extent of protein binding determines distribution of doxycycline and meropenem into ISF, and as a result of high protein binding, ISF doxycyine concentrations are lower than plasma total doxy cycline concentrations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2003 journal article
Disposition and analgesic cockatoos effects of fentanyl in white (Cacatua alba)
JOURNAL OF AVIAN MEDICINE AND SURGERY, 17(3), 124–130.
author keywords: fentanyl; opioids; analgesia; pharmacokinetics; psittaciformes; cockatoo; Cacatua alba
TL;DR:
Although the 0.2 mg/kg SC dose provided significant analgesia in some birds, fentanyl at this dose is not recommended as a routine analgesic agent because a large volume of drug must be injected and this dose causes hyperactivity in some Birds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2003 journal article
Furosemide continuous rate infusion in the horse: Evaluation of enhanced efficacy and reduced side effects
JOURNAL OF VETERINARY INTERNAL MEDICINE, 17(6), 887–895.
author keywords: electrolyte; equine; fluid balance; frusemide; lasix; loop diuretic
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2003 chapter
Once-daily Aminoglycoside Dosing Regimens
In N. E. Robinson (Ed.), Current Therapy in Equine Medicine (5th ed., pp. 850–853).
Ed(s): N. Robinson
Source: NC State University Libraries
Added: April 13, 2019
2003 journal article
Pharmacokinetics of florfenicol in loggerhead sea turtles (Caretta caretta) after single intravenous and intramuscular injections
Journal of Zoo and Wildlife Medicine, 34(1), 3–8.
TL;DR:
Florfenicol does not appear to be a practical antibiotic in sea turtles when administered at these doses, and plasma florfenicol plasma concentrations were below the minimum inhibitory concentrations for sensitive bacteria within 1 hr.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2003 journal article
Pharmacologic management in veterinary behavioral medicine
Veterinary Clinics of North America: Small Animal Practice, 33(2), 365–404.
MeSH headings : Animals; Anxiety Disorders / drug therapy; Behavior, Animal; Cat Diseases / drug therapy; Cats / metabolism; Dog Diseases / drug therapy; Dogs / metabolism; Psychotropic Drugs / pharmacokinetics; Psychotropic Drugs / therapeutic use; Veterinary Drugs
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2002 article
Pharmacokinetics after intravenous and oral administration of enrofloxacin in sheep
Bermingham, E. C., & Papich, M. G. (2002, July). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 63, pp. 1012–1017.
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Biological Availability; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Cross-Over Studies; Enrofloxacin; Female; Fluoroquinolones; Half-Life; Injections, Intravenous / veterinary; Quinolones / administration & dosage; Quinolones / blood; Quinolones / pharmacokinetics; Sheep / blood; Sheep / metabolism
TL;DR:
Enrofloxacin administered orally to sheep has a prolonged half-life and high oral bioavailability and was sufficient to achieve a plasma concentration of 8 to 10 times the minimum inhibitory concentration of any microorganism with an MIC < or = 0.29 microg/ml.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2002 journal article
Pharmacokinetics and endometrial tissue concentrations of enrofloxacin and the metabolite ciprofloxacin after i.v. administration of enrofloxacin to mares
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 25(5), 343–350.
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Chromatography, High Pressure Liquid / veterinary; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Endometrium / metabolism; Enrofloxacin; Female; Fluoroquinolones; Horses / metabolism; Infusions, Intravenous / veterinary; Quinolones / administration & dosage; Quinolones / blood; Quinolones / pharmacokinetics
TL;DR:
Endometrial tissue concentrations taken from the mares after dosing showed that enrofloxacin and ciprofloxin both penetrate this tissue adequately after systemic administration and would attain concentrations high enough in the tissue fluids to treat infections of the endometrium caused by susceptible bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2002 journal article
Pharmacokinetics of azithromycin in foals after i.v. and oral dose and disposition into phagocytes
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 25(2), 99–104.
MeSH headings : Actinomycetales Infections / drug therapy; Actinomycetales Infections / veterinary; Administration, Oral; Animals; Animals, Newborn; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Area Under Curve; Azithromycin / administration & dosage; Azithromycin / blood; Azithromycin / pharmacokinetics; Azithromycin / therapeutic use; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid / veterinary; Female; Horse Diseases / drug therapy; Horses / metabolism; Infusions, Intravenous / veterinary; Macrophages, Alveolar / metabolism; Male; Phagocytes / metabolism; Rhodococcus equi
TL;DR:
The properties of azithromycin suggest that it may be an alternative to erythromycin for treatment of Rhodococcus equi pneumonia in foals and its disposition in plasma, polymorphonuclear leukocytes (PMN), and alveolar cells was examined to investigate this possibility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2002 journal article
Pharmacokinetics of fluconazole in loggerhead sea turtles (Caretta caretta) after single intravenous and subcutaneous injections, and multiple subcutaneous injections
Journal of Zoo and Wildlife Medicine, 33(1), 29–35.
TL;DR:
It is suggested that fluconazole can be effectively administered to sea turtles at a dosage of 10 mg/kg every 5 days after a loading dose of 21mg/kg, and the terminal half-life after the last dose was calculated at 143 hr.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2002 article
Plasma pharmacokinetics and tissue fluid concentrations of meropenem after intravenous and subcutaneous administration in dogs
Bidgood, T., & Papich, M. G. (2002, December). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 63, pp. 1622–1628.
MeSH headings : Animals; Area Under Curve; Cross-Over Studies; Dogs / blood; Dogs / metabolism; Extracellular Space / chemistry; Female; Half-Life; Injections, Intravenous / veterinary; Injections, Subcutaneous / veterinary; Meropenem; Protein Binding / physiology; Random Allocation; Thienamycins / blood; Thienamycins / pharmacokinetics; Thienamycins / urine; Ultrafiltration / veterinary
TL;DR:
Analysis of the data revealed that tissue fluid and plasma (unbound fraction) concentrations were similar, and because of the kinetic similarity of meropenem in the extravascular and vascular spaces, tissue fluid concentrations can be predicted from plasma concentrations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2002 journal article
Putative drug-related pemphigus foliaceus in four dogs
VETERINARY DERMATOLOGY, 13(4), 195–202.
author keywords: adverse drug reaction; antibiotics; dogs; pemphigus foliaceus; skin lesions
MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Diagnosis, Differential; Dog Diseases / chemically induced; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Drug Eruptions / diagnosis; Drug Eruptions / veterinary; Female; Immunosuppressive Agents / therapeutic use; Male; Pemphigus / diagnosis; Pemphigus / veterinary
TL;DR:
Four dogs developed cutaneous lesions following the administration of various antibiotics, Histopathology of the lesions was compatible with pemphigus foliaceus, although apoptotic cells suggestive of erythema multiforme were seen in two cases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2002 book
Saunders Handbook of Veterinary Drugs
(1st ed.). Philadelphia, PA: Saunders.
Source: NC State University Libraries
Added: March 29, 2019
2001 journal article
Adverse reactions to sulfonamide administration
Compendium for Continuing Education for the Practicing Veterinarian, 3(4), 5–12.
Source: NC State University Libraries
Added: April 13, 2019
2001 chapter
Antifungal and antiviral drugs
In Veterinary Pharmacology: Therapeutics (8th ed.) (pp. 918–946). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
2001 chapter
Chloramphenicol and derivatives, macrolides, lincosamides, and miscellaneous antibiotics
In Veterinary pharmacology and therapeutics (8th ed.) (pp. 868–897). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
Comparison of cefepime pharmacokinetics in neonatal foals and adult dogs
Journal of Veterinary Pharmacology and Therapeutics, 24(3), 187–192.
MeSH headings : Animals; Animals, Newborn; Body Weight; Cefepime; Cephalosporins / administration & dosage; Cephalosporins / blood; Cephalosporins / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Dogs / metabolism; Female; Horses / metabolism; Injections, Intravenous / veterinary; Male
TL;DR:
D doses for cefepime, a potentially useful antibiotic for neonatal foals and dogs, are determined from the pharmacokinetic values.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018
2001 journal article
Experimental infection of cats with Tritrichomonas foetus
American Journal of Veterinary Research, 62(11), 1690–1697.
MeSH headings : Animals; Antigens, Protozoan / analysis; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / therapeutic use; Cat Diseases / drug therapy; Cat Diseases / parasitology; Cats; Cryptosporidiosis / complications; Cryptosporidiosis / drug therapy; Cryptosporidiosis / veterinary; Cryptosporidium / growth & development; Diarrhea / drug therapy; Diarrhea / parasitology; Diarrhea / veterinary; Feces / parasitology; Female; Intestinal Diseases / drug therapy; Intestinal Diseases / parasitology; Intestinal Diseases / veterinary; Intestinal Mucosa / parasitology; Nitro Compounds; Parasite Egg Count / veterinary; Prednisolone / administration & dosage; Prednisolone / therapeutic use; Protozoan Infections / complications; Protozoan Infections / drug therapy; Protozoan Infections, Animal; Specific Pathogen-Free Organisms; Thiazoles / administration & dosage; Thiazoles / therapeutic use; Tritrichomonas foetus
TL;DR:
After experimental inoculation in cats, T. foetus organisms colonize the ileum, cecum, and colon, reside in close contact with the epithelium, and are associated with transient diarrhea that is exacerbated by coexisting cryptosporidiosis but not treatment with prednisolone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2001 chapter
Fluoroquinolones antimicrobial drugs
In Veterinary pharmacology and therapeutics (8th ed.) (Vol. 45, pp. 898–917). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
Pharmacokinetics and adverse effects of butorphanol administered by single intravenous injection or continuous intravenous infusion in horses
AMERICAN JOURNAL OF VETERINARY RESEARCH, 62(2), 183–189.
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / adverse effects; Analgesics, Opioid / pharmacokinetics; Animals; Behavior, Animal / drug effects; Butorphanol / administration & dosage; Butorphanol / adverse effects; Butorphanol / pharmacokinetics; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Gastrointestinal Transit / drug effects; Half-Life; Horses / metabolism; Infusions, Intravenous / veterinary; Injections, Intravenous / veterinary; Male
TL;DR:
Continuous infusion of butorphanol may be a useful treatment to induce analgesia in horses after a single IV injection was associated with adverse behavioral and gastrointestinal tract effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2001 journal article
Pharmacokinetics of fluconazole following intravenous and oral administration and body fluid concentrations of fluconazole following repeated oral dosing in horses
AMERICAN JOURNAL OF VETERINARY RESEARCH, 62(10), 1606–1611.
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Aqueous Humor / chemistry; Area Under Curve; Biological Availability; Cerebrospinal Fluid / chemistry; Chromatography, High Pressure Liquid / veterinary; Cross-Over Studies; Female; Fluconazole / administration & dosage; Fluconazole / blood; Fluconazole / pharmacokinetics; Half-Life; Horses / metabolism; Injections, Intravenous / veterinary; Male; Random Allocation; Synovial Fluid / chemistry; Urine / chemistry
TL;DR:
Fluentazole may be an appropriate agent for treatment of fungal infections in horses and bioavailability of fluconazole was high after oral administration to horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2001 journal article
Plasma concentrations of doxycycline in selected psittacine birds when administered in water for potential treatment of Chlamydophila psittaci infection
JOURNAL OF AVIAN MEDICINE AND SURGERY, 15(4), 276–282.
author keywords: chlamydiosis; psittacosis; Psittaciformes; pharmacology; antibiotics; Chlamydia psittaci; Chlamydophila psittaci
TL;DR:
The results of this study suggest that doxycycline-medicated water can safely maintain plasma concentrations adequate for treating avian Chlamydophila infections in African grey parrots and Goffin's cockatoos housed under standardized conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2001 review
Potential and problems of developing transdermal patches for veterinary applications
[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 50(3), 175–203.
author keywords: veterinary drug delivery; transdermal drug delivery; fentanyl; iontophoresis
MeSH headings : Administration, Cutaneous; Animal Diseases / drug therapy; Animals; Diffusion; Drug Delivery Systems; Fentanyl / pharmacokinetics; Humans; Iontophoresis; Pesticides / pharmacokinetics; Skin / anatomy & histology; Skin / metabolism; Skin Absorption
TL;DR:
The human transdermal fentanyl patch has been successfully used in cats and dogs for post-operative analgesia and a number of insecticides have been developed in liquid "pour-on" formulations that illustrate the efficacy of this route of administration for veterinary species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2001 journal article
Use of adult cat serum to correct failure of passive transfer in kittens
Journal of the American Veterinary Medical Association, 219(10), 1401–1405.
MeSH headings : Age Factors; Animal Feed; Animals; Animals, Newborn / blood; Animals, Newborn / immunology; Animals, Suckling / blood; Animals, Suckling / immunology; Cats / blood; Cats / immunology; Colostrum / immunology; Female; Food, Formulated / standards; Immunity, Maternally-Acquired / immunology; Immunodiffusion / veterinary; Immunoglobulin G / analysis; Immunoglobulin G / blood; Injections, Intraperitoneal / veterinary; Injections, Subcutaneous / veterinary; Male; Specific Pathogen-Free Organisms
TL;DR:
Results suggest that adult cat serum may be used as an immunoglobulin supplement in colostrum-deprived kittens, although the minimum concentration of IgG necessary to protect kittens from infection is unknown.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2000 journal article
Administration of ticarcillin in combination with clavulanic acid intravenously and intrauterinely to clinically normal oestrous mares
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 23(6), 373–378.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Chromatography, High Pressure Liquid; Clavulanic Acid / administration & dosage; Clavulanic Acid / blood; Clavulanic Acid / pharmacokinetics; Cross-Over Studies; Drug Therapy, Combination; Female; Half-Life; Horses; Injections, Intravenous; Microbial Sensitivity Tests; Penicillins / administration & dosage; Penicillins / blood; Penicillins / pharmacokinetics; Ticarcillin / administration & dosage; Ticarcillin / blood; Ticarcillin / pharmacokinetics; Tissue Distribution
TL;DR:
It appears that addition of clavulanate to the formulation for treatment of i.u. infections in mares is of questionable value based on these concentrations, which would necessitate frequent treatment in order to maintain drug concentrations above the minimum inhibitory concentrations (MIC) throughout the treatment period.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2000 journal article
Amoxicillin pharmacokinetics in harbor seals (Phoca vitulina) and northern elephant seals (Mirounga angustirostris) following single dose intravenous administration: implications for interspecific dose sealing
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 23(4), 223–228.
MeSH headings : Amoxicillin / administration & dosage; Amoxicillin / blood; Amoxicillin / pharmacokinetics; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Chromatography, High Pressure Liquid / veterinary; Dose-Response Relationship, Drug; Injections, Intravenous / veterinary; Seals, Earless / classification; Seals, Earless / metabolism
TL;DR:
A true physiologic difference in drug handling, possibly related to renal perfusion or tubal secretory efficiency could affect amoxicillin kinetics in these species, and longer administration intervals may be appropriate for elephant seals as compared to harbor seals when administering multiple dose amoxicalin therapy at 20 mg/kg.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2000 journal article
Antifungal dermatologic agents: Azoles and allylamines
Compendium on Continuing Education for the Practicing Veterinarian, 22(6), 548–559.
Source: NC State University Libraries
Added: August 6, 2018
2000 chapter
Antihistamines: current therapeutic use
In J. D. Bonagura (Ed.), Kirk's Current Veterinary Therapy (13th ed., pp. 48–53). Philadelphia: W.B. Saunders Company.
Ed(s): J. Bonagura
Source: NC State University Libraries
Added: August 6, 2018
2000 chapter
Antimicrobial drugs
In S. J. Ettinger & E. C. Feldman (Eds.), Textbook of Veterinary Internal Medicine (5th ed., pp. 301–307). Philadelphia: W.B. Saunders Company.
Ed(s): S. Ettinger & E. Feldman
Source: NC State University Libraries
Added: April 13, 2019
2000 chapter
Bacterial resistance
In J. D. Bonagura (Ed.), Kirk's Current Veterinary Therapy (13th ed., pp. 262–267). Philadelphia: W.B. Saunders Company.
Ed(s): J. Bonagura
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Comparison of pharmacokinetics of fentanyl after intravenous and transdermal administration in cats
AMERICAN JOURNAL OF VETERINARY RESEARCH, 61(6), 672–677.
MeSH headings : Administration, Topical; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Area Under Curve; Cats / metabolism; Fentanyl / administration & dosage; Fentanyl / blood; Fentanyl / pharmacokinetics; Half-Life; Injections, Intravenous / veterinary; Radioimmunoassay / veterinary; Regression Analysis
TL;DR:
In cats, transdermal administration provides sustained plasma concentrations of fentanyl citrate throughout a 5-day period and has potential for use in cats for long-term control of pain after surgery or chronic pain associated with cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2000 journal article
Evaluation of ciprofloxacin as a representative of veterinary fluoroquinolones in susceptibility testing
Journal of Clinical Microbiology, 38(4), 1636–1637.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Pharmacokinetics of enrofloxacin administered intravenously and orally to foals
AMERICAN JOURNAL OF VETERINARY RESEARCH, 61(6), 706–709.
MeSH headings : Administration, Oral; Animals; Animals, Newborn / metabolism; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / metabolism; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Chromatography, High Pressure Liquid / veterinary; Ciprofloxacin / blood; Computer Simulation; Cross-Over Studies; Enrofloxacin; Fluoroquinolones; Half-Life; Horses / metabolism; Injections, Intravenous / veterinary; Quinolones / administration & dosage; Quinolones / blood; Quinolones / metabolism; Quinolones / pharmacokinetics; Regression Analysis
TL;DR:
Compared with adult horses given 5 mg of enrofloxacin/kg IV, foals have higher AUC0-infinity, longer t1/2beta, and lower clearance, and computer modeling suggests that 2.5 to 10 mg of dextrose/kg administered every 24 hours would be effective in foals, depending on minimum inhibitory concentration of the pathogen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2000 journal article
Pharmacokinetics of gentamicin in mares in late pregnancy and early lactation
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 23(6), 359–363.
MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Female; Fluorescence Polarization Immunoassay; Gentamicins / blood; Gentamicins / pharmacokinetics; Half-Life; Horses; Injections, Intravenous; Lactation; Metabolic Clearance Rate; Pregnancy
TL;DR:
There were no differences in drug distribution and clearance between pregnant and nonpregnant lactating mares and Gentamicin was undetectable in plasma samples from these foals and, therefore, apparently does not cross the placenta of mares at term.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2000 journal article
Pharmacologic Considerations for Opiate Analgesic and Nonsteroidal Anti-Inflammatory Drugs
Veterinary Clinics of North America: Small Animal Practice, 30(4), 815–837.
MeSH headings : Analgesia / adverse effects; Analgesia / veterinary; Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Drug Interactions; Narcotics / adverse effects; Narcotics / pharmacology
TL;DR:
The pharmacologic features of opioid analgesic drugs or nonsteroidal anti-inflammatory drugs are considered and a basis for important interactions, contraindications, and adverse effects is provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: February 27, 2019
2000 review
Pharmacologic considerations for opiate analgesic and nonsteroidal anti-inflammatory drugs
[Review of ]. Veterinary Clinics of North America. Small Animal Practice, 30(4), 815.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Preliminary investigation of doxycycline plasma concentrations in cockatiels (Nymphicus hollandicus) after administration by injection or in water or feed
Journal of Avian Medicine and Surgery, 14(1), 23–30.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Serum oxytetracycline concentrations in African elephant (Loxodonta africana) calves after long-acting formulation injection
Journal of Zoo and Wildlife Medicine, 31(1), 41–46.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Traditional antifungal dermatologic agents
Compendium on Continuing Education for the Practicing Veterinarian, 22(5), 461.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Acute renal failure in four cats treated with paromomycin
Journal of the American Veterinary Medical Association, 215(12), 1821–1823.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Chronic and Acute Compressive Spinal Cord Lesions in Dogs due to Intervertebral Disc Herniation Are Associated With Elevation in Lumbar Cerebrospinal Fluid Glutamate Concentration
Journal of Neurotrauma, 16(12), 1215–1224.
author keywords: cerebrospinal fluid; dog; excitotoxicity; glutamate; spinal-cord compression; spinal cord injury
MeSH headings : Acute Disease; Animals; Chronic Disease; Dogs; Glutamic Acid / cerebrospinal fluid; Intervertebral Disc Displacement / complications; Lumbar Vertebrae; Lumbosacral Region; Osmolar Concentration; Reference Values; Spinal Cord Injuries / cerebrospinal fluid; Spinal Cord Injuries / etiology; Thoracic Vertebrae
TL;DR:
Dogs with chronic compressive thoracolumbar lesions have a two-fold elevation of CSF glutamate concentration, suggesting that excitotoxicity may also be a component of chronic spinal cord compression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
1999 journal article
Drug disposition and dosage determination of once daily administration of gentamicin sulfate in horses after abdominal surgery
Journal of the American Veterinary Medical Association, 215(4), 503–506.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Efficacy of Doxycycline, Azithromycin, or Trovafloxacin for Treatment of Experimental Rocky Mountain Spotted Fever in Dogs
Antimicrobial Agents and Chemotherapy, 43(4), 813–821.
MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / therapeutic use; Anti-Infective Agents / blood; Anti-Infective Agents / therapeutic use; Azithromycin / blood; Azithromycin / therapeutic use; Capillary Permeability / drug effects; DNA, Bacterial / analysis; Dogs; Doxycycline / blood; Doxycycline / therapeutic use; Female; Fluoroquinolones; Guinea Pigs; Male; Naphthyridines / blood; Naphthyridines / therapeutic use; Polymerase Chain Reaction; Rickettsia rickettsii / drug effects; Rickettsia rickettsii / isolation & purification; Rocky Mountain Spotted Fever / drug therapy; Rocky Mountain Spotted Fever / immunology; Treatment Outcome
TL;DR:
Doxycycline and trovafloxacin was as efficacious as doxycycline but azithromycin proved less efficacious, possibly due to the short duration of administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
1999 journal article
Pharmacokinetics of ceftazidime in loggerhead sea turtles (Caretta caretta) after single intravenous and intramuscular injections
Journal of Zoo and Wildlife Medicine, 30(1), 32–35.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Pharmacokinetics of enrofloxacin in reptiles
Compendium on Continuing Education for the Practicing Veterinarian, 21(12M), 110–114.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Pharmacokinetics of ibuprofen after intravenous and oral administration and assessment of safety of administration to healthy foals
American Journal of Veterinary Research, 60(9), 1066–1073.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Regional intravenous perfusion of the distal limb of horses with amikacin sulfate
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 22(1), 68–71.
MeSH headings : Amikacin / administration & dosage; Amikacin / blood; Amikacin / pharmacokinetics; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Chemotherapy, Cancer, Regional Perfusion / veterinary; Horses / metabolism; Synovial Fluid / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
1999 review
The use of fluoroquinolones in veterinary dermatology
[Review of ]. VETERINARY DERMATOLOGY, 10(3), 193–204.
author keywords: dog; fluoroquinolones; otitis externa; Pseudomonas aeruginosa; pyoderma; Staphylococcus intermedius
TL;DR:
Fluoroquinolones should be considered in circumstances where canine pyoderma has been refractory to appropriate 'first line' antibiotics, and are most useful in the management of recurrent Pyoderma and in chronic, deep pyoderMA with extensive scar tissue.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
1998 journal article
Antibacterial choices for skin infections
North American Veterinary Conference. Veterinary Proceedings, 12(1998), 188–190.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Antibacterial drug therapy - Focus on new drugs
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 28(2), 215-+.
MeSH headings : Aminoglycosides; Animals; Anti-Bacterial Agents / adverse effects; Anti-Bacterial Agents / classification; Anti-Bacterial Agents / therapeutic use; Anti-Infective Agents / classification; Anti-Infective Agents / therapeutic use; Bacterial Infections / drug therapy; Bacterial Infections / veterinary; Carbapenems / classification; Carbapenems / therapeutic use; Cephalosporins / classification; Cephalosporins / therapeutic use; Fluoroquinolones; Glycopeptides; Macrolides; Penicillins / classification; Penicillins / therapeutic use
TL;DR:
This article will focus on the drugs for which there has been a recent or renewed interest in veterinary medicine and recent information has provided us with updated dosage guidelines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
1998 journal article
Comparison of transdermal fentanyl and intramuscular oxymorphone on post-operative behaviour after ovariohysterectomy in dogs
RESEARCH IN VETERINARY SCIENCE, 65(3), 245–251.
MeSH headings : Administration, Cutaneous; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacology; Animals; Behavior, Animal / drug effects; Dogs; Female; Fentanyl / administration & dosage; Fentanyl / pharmacology; Hysterectomy / veterinary; Injections, Intramuscular; Ovariectomy / veterinary; Oxymorphone / administration & dosage; Oxymorphone / pharmacology; Postoperative Period
TL;DR:
This study showed that transdermal fentanyl and i.m. oxymorphone produced comparable analgesic effects over a 24 hour recording period, and that I.M. oxyMorphone produced significantly more sedation and lower rectal temperatures than trans dermal fentanyl.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
1998 journal article
Depletion of penicillin G residues in tissues, plasma and injection sites of market pigs injected intramuscularly with procaine penicillin G
Food Additives and Contaminants, 15(4), 421–426.
MeSH headings : Adipose Tissue / chemistry; Animals; Chromatography, Liquid; Drug Residues; Food Contamination / analysis; Injections, Intramuscular; Kidney / chemistry; Liver / chemistry; Meat; Muscle, Skeletal / chemistry; Penicillin G / administration & dosage; Penicillin G / analysis; Penicillin G / blood; Penicillins / administration & dosage; Penicillins / analysis; Penicillins / blood; Skin / chemistry; Swine; Time Factors
TL;DR:
The technique used for neck injections was critical to obtain intramuscular rather than intermuscular injections and penicillin G was found at all times in the kidneys of the groups of pigs that received the high dose.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: March 2, 2019
1998 journal article
Hematologic and serum biochemical variables and plasma corticotropin concentration in healthy aged horses
American Journal of Veterinary Research, 59(10), 1247–1251.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Optimum strategy for antibacterial therapy
North American Veterinary Conference. Veterinary Proceedings, 12(1998), 607–608.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Pharmacokinetics of cisapride in horses after intravenous and rectal administration: Erratum
American Journal of Veterinary Research, 59(4), 396.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Population pharmacokinetics of gentamicin in horses
American Journal of Veterinary Research, 59(12), 1589–1598.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Disposition of enrofloxacin and its metabolite ciprofloxacin after intravascular injection in juvenile burmese pythons (Python molurus bivittatus)
Journal of Zoo and Wildlife Medicine, 28(1), 71–79.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Efficacy of enrofloxacin or doxycycline for treatment of Bartonella henselae or Bartonella clarridgeiae infection in cats.
Antimicrobial Agents and Chemotherapy, 41(11), 2448–2455.
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / therapeutic use; Anti-Infective Agents / blood; Anti-Infective Agents / therapeutic use; Bartonella Infections / drug therapy; Bartonella Infections / veterinary; Bartonella henselae / drug effects; Cat Diseases / drug therapy; Cats; Chromatography, High Pressure Liquid; Doxycycline / blood; Doxycycline / therapeutic use; Drug Evaluation, Preclinical; Enrofloxacin; Fluoroquinolones; Microbial Sensitivity Tests; Quinolones / blood; Quinolones / therapeutic use
TL;DR:
The results suggest that MICs obtained with axenic media do not predict antimicrobial activity against intracellular Bartonella, that a long treatment course is required to eliminate infection, and that duration of therapy correlates with pretreatment bacterial load.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
1997 chapter
Formulary
In L. P. Tilley & F. W. K. Smith (Eds.), The 5 Minute Veterinary Consult (pp. 1180–1240). Baltimore: Williams & Wilkins.
Ed(s): L. Tilley & F. Smith
Source: NC State University Libraries
Added: July 1, 2022
1997 journal article
Pharmacokinetics of cisapride in horses after intravenous and rectal administration
American Journal of Veterinary Research, 58(12), 1427–1430.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Pharmacology and toxicology special issue
Journal of Zoo and Wildlife Medicine, 28(1), 1–2.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Prednisolone at anti-inflammatory or immunosuppressive dosages in conjunction with doxycycline does not potentiate the severity of Rickettsia rickettsii infection in dogs.
Antimicrobial Agents and Chemotherapy, 41(1), 141–147.
MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / therapeutic use; Anti-Inflammatory Agents / blood; Anti-Inflammatory Agents / therapeutic use; Antibodies, Bacterial / analysis; Dogs; Doxycycline / blood; Doxycycline / therapeutic use; Drug Therapy, Combination; Female; Immunosuppressive Agents / blood; Immunosuppressive Agents / therapeutic use; Prednisolone / blood; Prednisolone / therapeutic use; Rickettsia rickettsii / immunology; Rickettsia rickettsii / isolation & purification; Rocky Mountain Spotted Fever / blood; Rocky Mountain Spotted Fever / drug therapy
TL;DR:
It is concluded that the concurrent use of anti-inflammatory or immunosuppressive doses of prednisolone in conjunction with doxycycline, early in the course of experimental R MSF, confers no clinically relevant detrimental effects and that additional studies might be indicated to detect possible beneficial effects in cases of severe or potentially fulminant RMSF.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
1997 review
Principles of analgesic drug therapy
[Review of ]. SEMINARS IN VETERINARY MEDICINE AND SURGERY-SMALL ANIMAL, 12(2), 80–93.
MeSH headings : Analgesics, Opioid / adverse effects; Analgesics, Opioid / therapeutic use; Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Drug Interactions; Humans; Pain / drug therapy; Pain / veterinary; Practice Guidelines as Topic
TL;DR:
The drugs most often used for pain relief in animals are the nonsteroidal antiinflammatory drugs (NSAIDS) and the opioid analgesics and Carprofen is a new drug with a low incidence of side effects and its popularity is increasing at a fast rate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
1996 journal article
Ampicillin and amoxicillin residue detection in milk, using microbial receptor assay (Charm II) and liquid chromatography methods, after extra-label administration of the drugs to lactating cows
American Journal of Veterinary Research, 57, 73–78.
Source: NC State University Libraries
Added: April 13, 2019
1996 journal article
Disposition of transdermally administered fentanyl in dogs
American Journal of Veterinary Research, 57, 715–719.
Source: NC State University Libraries
Added: April 13, 2019
1996 journal article
Drug Residue Considerations for Anesthetics and Adjunctive Drugs in Food-Producing Animals
Veterinary Clinics of North America: Food Animal Practice, 12(3), 693–706.
MeSH headings : Adjuvants, Anesthesia / pharmacokinetics; Anesthetics / pharmacokinetics; Animals; Drug Residues / analysis; Half-Life; Ruminants; Swine
TL;DR:
The risks associated with residues of these drugs in food-producing animals, as well as the veterinarian's responsibility to reduce this risk, are discussed, and suggestions for prevention in each of the major anesthetic drug classes are described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: February 27, 2019
1996 journal article
Laboratory Testing of the Charm Test II Receptor Assays and the Charm Farm Test with Tissues and Fluids from Hogs Fed Sulfamethazine, Chlortetracycline, and Penicillin G
Journal of Food Protection, 59(2), 161–166.
author keywords: Charm Test II; Charm Farm Test; swine; antimicrobial; residue testing
TL;DR:
The potentials of the Charm Test II receptor assays for the detection of residues of sulfonamides, tetracyclines, and β-lactams and the Charm Farm Test for screening for antimicrobial residues were tested.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: March 2, 2019
1996 journal article
Pharmacokinetic model for cefazolin distribution during total hip arthroplasty
American Journal of Veterinary Research, 57, 720–723.
Source: NC State University Libraries
Added: August 6, 2018
1996 journal article
Residue depletion in tissues and fluids from swine fed sulfamethazine, chlortetracycline and penicillin G in combination
Food Additives and Contaminants, 13(3), 287–292.
MeSH headings : Animals; Anti-Bacterial Agents; Anti-Infective Agents; Chlortetracycline / analysis; Chlortetracycline / pharmacokinetics; Drug Residues / analysis; Female; Kidney / chemistry; Liver / chemistry; Male; Muscles / chemistry; Orchiectomy; Penicillin G / analysis; Penicillin G / pharmacokinetics; Penicillins; Sulfamethazine / analysis; Sulfamethazine / pharmacokinetics; Swine
TL;DR:
The results suggest that, if the label withdrawal period of 10 days is observed, an increase in the dosage of up to three times the recommended rate is unlikely to increase significantly the risk that residues would occur in the tissues of treated hogs at concentrations which exceed MRLs.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: March 2, 2019
1995 journal article
Absorption of diazepam after its rectal administration in dogs
American Journal of Veterinary Research, 56(12), 1629.
Source: NC State University Libraries
Added: August 6, 2018
1995 journal article
An American Veterinary Medical Association perspective [Professional flexible labeling. An interactive workshop on first principles, April, 1995]
Journal of the American Veterinary Medical Association, 207(7), 871.
Source: NC State University Libraries
Added: August 6, 2018
1995 chapter
Antimicrobial drugs
In S. J. Ettinger & E. C. Feldman (Eds.), Textbook of Veterinary Internal Medicine (4th ed., pp. 272–283). Philadelphia: W.B. Saunders Company.
Ed(s): S. Ettinger & E. Feldman
Source: NC State University Libraries
Added: April 13, 2019
1995 journal article
Comparison of four commercially available rapid test kits with liquid chromatography for detecting penicillin G residues in bovine plasma
Journal of AOAC International, 78, 1144–1152.
Source: NC State University Libraries
Added: April 13, 2019
1995 chapter
Empiric antibiotic therapy
In J. D. Bonagura (Ed.), Kirk's Current Veterinary Therapy (12th ed., pp. 276–279). Philadelphia: W.B. Saunders Company.
Ed(s): J. Bonagura
Source: NC State University Libraries
Added: April 17, 2019
1995 chapter
Incompatible critical care drug combinations
In J. D. Bonagura (Ed.), Kirk's Current Veterinary Therapy (12th ed., pp. 194–198). Philadelphia: W.B. Saunders Company.
Ed(s): J. Bonagura
Source: NC State University Libraries
Added: April 13, 2019
1995 article
PHARMACOKINETICS OF OXYTETRACYCLINE ADMINISTERED INTRAVENOUSLY TO 4 TO 5 DAY-OLD FOALS
PAPICH, M. G., WRIGHT, A. K., PETRIE, L., & KORSRUD, G. O. (1995, October). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 18, pp. 375–378.
MeSH headings : Animals; Animals, Newborn / metabolism; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Half-Life; Horses / metabolism; Injections, Intravenous / veterinary; Oxytetracycline / administration & dosage; Oxytetracycline / blood; Oxytetracycline / pharmacokinetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
1995 chapter
Pharmacologic principles
In S. J. Ettinger & E. C. Feldman (Eds.), Textbook of Veterinary Internal Medicine (4th ed., pp. 264–271). Philadelphia: W.B. Saunders Company.
Ed(s): S. Ettinger & E. Feldman
Source: NC State University Libraries
Added: April 13, 2019
1995 journal article
Potential for oxytetracycline administration by three routes to cause milk residues in lactating cows, as detected by radioimmunoassay (Charm II) and high-performance liquid chromatography test methods
American Journal of Veterinary Research, 56, 70–77.
Source: NC State University Libraries
Added: April 13, 2019
1995 journal article
Preliminary comparison of plasma concentrations of gentamicin injected into the cranial and caudal limb musculature of the eastern box turtle (Terrapene carolina carolina)
Journal of Zoo and Wildlife Medicine, 26(2), 265–268.
Source: NC State University Libraries
Added: August 6, 2018
1995 journal article
Professional flexible labeling: an American Veterinary Medical Association perspective
Journal of the American Veterinary Medical Association, 207, 871–874.
Source: NC State University Libraries
Added: April 13, 2019
1995 chapter
Unapproved use of drugs in animals
In J. D. Bonagura (Ed.), Kirk's Current Veterinary Therapy (12th ed., pp. 48–52). Philadelphia: W.B. Saunders Company.
Ed(s): J. Bonagura
Source: NC State University Libraries
Added: April 13, 2019
1994 journal article
Depletion of penicillin G residues in tissues and injection sites of yearling beef steers dosed with benzathine penicillin G alone or in combination with procaine penicillin G
Food Additives and Contaminants, 11(1), 1–6.
author keywords: BENZATHINE AND PROCAINE PENICILLIN-G; DEPLETION; STEERS; INJECTION SITES; TISSUES
MeSH headings : Animals; Body Weight / drug effects; Buttocks; Cattle / metabolism; Chromatography, Liquid; Drug Combinations; Drug Residues / pharmacokinetics; Injections, Intramuscular; Injections, Subcutaneous; Kidney / metabolism; Liver / metabolism; Male; Muscles / metabolism; Neck; Penicillin G Benzathine / administration & dosage; Penicillin G Benzathine / pharmacokinetics; Penicillin G Procaine / administration & dosage; Penicillin G Procaine / pharmacokinetics; Tissue Distribution
TL;DR:
The persistence of peniillin G residues at the injection sites in all the treatment groups appears to be attributable primarily to benzathine penicillin G.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: March 2, 2019
1994 journal article
Disposition of penicillin G after administration of benzathine penicillin G, or a combination of benzathine penicillin G and procaine penicillin G in cattle
American Journal of Veterinary Research, 55(6), 825.
Source: NC State University Libraries
Added: August 6, 2018
1994 journal article
Panel Consensus Report: Human Food Safety: Review of the 1993 Veterinary Drug Bioequivalence Workshop
Journal of Veterinary Pharmacology and Therapeutics, 17, 115–116.
Ed(s): M. Martinez & J. Riviere
Source: NC State University Libraries
Added: April 13, 2019
1994 journal article
Pharmacokinetics of enrofloxacin after a single intramuscular injection in indian star tortoises (Geochelone elegans)
Journal of Zoo and Wildlife Medicine, 25, 88–94.
Source: NC State University Libraries
Added: April 13, 2019
1994 journal article
Simultaneous determination of enrofloxacin and its primary metabolite ciprofloxacin in bovine milk and plasma by ion-pairing liquid chromatography
Journal of Chromatography B: Biomedical Sciences and Applications, 658(2), 341–348.
MeSH headings : Animals; Anti-Infective Agents / analysis; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Biotransformation; Cattle; Chromatography, Ion Exchange; Ciprofloxacin / analysis; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Enrofloxacin; Fluoroquinolones; Injections, Intravenous; Milk / chemistry; Quinolones / analysis; Quinolones / blood; Quinolones / pharmacokinetics; Spectrophotometry, Ultraviolet; Ultrafiltration
TL;DR:
A simple and sensitive high-performance liquid chromatographic method has been developed for the simultaneous determination of enrofloxacin and ciprofl oxacin in bovine milk and plasma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018
1994 journal article
Single-dose pharmacokinetics of cefazolin in bovine synovial fluid after intravenous regional injection
Journal of Veterinary Pharmacology and Therapeutics, 17(1), 31–37.
MeSH headings : Animals; Biological Availability; Cattle / metabolism; Cefazolin / administration & dosage; Cefazolin / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Female; Half-Life; Injections, Intravenous / veterinary; Synovial Fluid / metabolism; Tarsal Joints / metabolism
TL;DR:
Therapeutic concentrations of cefazolin in the synovial fluid of normal joints were reached and this injection technique could be used as an alternative to systemic administration of antibiotics to provide adequate concentrations in a localized area.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: March 2, 2019
1993 journal article
A study of the disposition of procaine penicillin G in feedlot steers following intramuscular and subcutaneous injection
Journal of Veterinary Pharmacology and Therapeutics, 16(3), 317–327.
MeSH headings : Animals; Biological Availability; Cattle / metabolism; Chromatography, High Pressure Liquid / veterinary; Drug Residues; Half-Life; Injections, Intramuscular / veterinary; Injections, Subcutaneous / veterinary; Male; Penicillin G / blood; Penicillin G Procaine / administration & dosage; Penicillin G Procaine / pharmacokinetics
TL;DR:
In this study, when procaine penicillin G was injected into the gluteal muscle, doses of 66,000 U/kg were necessary to produce plasma concentrations that were above a minimum inhibitory concentration (MIC) for peniillin G of 1.0 microgram/mL as compared to doses of 24,000U/kg.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: March 2, 2019
1993 journal article
Antiulcer Therapy
Veterinary Clinics of North America: Small Animal Practice, 23(3), 497–512.
MeSH headings : Animals; Antacids / therapeutic use; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Anti-Ulcer Agents / therapeutic use; Cats; Cimetidine / therapeutic use; Dogs; Gastrointestinal Diseases / drug therapy; Gastrointestinal Diseases / etiology; Gastrointestinal Diseases / veterinary; Histamine Agonists / therapeutic use; Horses; Humans; Omeprazole / therapeutic use; Prostaglandins, Synthetic / therapeutic use; Rats; Sucralfate / therapeutic use; Treatment Outcome; Ulcer / drug therapy; Ulcer / etiology; Ulcer / veterinary
TL;DR:
Perhaps older drugs to treat ulcers, such as antacids, are just as effective as the newer drugs, but veterinarians have all but abandoned these drugs in favor of H2-receptor antagonists, sucralfate, and omeprazole.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: February 27, 2019
1993 journal article
Depletion of intramuscularly and subcutaneously injected procaine penicillin G from tissues and plasma of yearling beef steers
Canadian Journal of Veterinary Research, 57, 223–230.
Source: NC State University Libraries
Added: April 13, 2019
1993 journal article
Use of breath hydrogen measurement to evaluate orocecal transit time in cats before and after treatment for hyperthyroidism
Canadian Journal of Veterinary Research, 57, 89–94.
Source: NC State University Libraries
Added: April 13, 2019
1992 journal article
Determination of penicillin G in bovine plasma by high-performance liquid chromatography after pre-column derivatization
Journal of Chromatography B: Biomedical Sciences and Applications, 576(2), 315–320.
MeSH headings : Animals; Cattle / blood; Chromatography, High Pressure Liquid / methods; Indicators and Reagents; Injections, Intramuscular; Male; Penicillin G / administration & dosage; Penicillin G / blood; Penicillin G / pharmacokinetics; Penicillin V / blood
TL;DR:
The method, which has a detection limit of 5 ng/ml (ppb) in bovine plasma, was used to quantitatively measure the concentrations of penicillin G in plasma of steers at a series of intervals after the intramuscular administration of a commercial formulation of procaine penicillins G.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, ORCID
Added: March 2, 2019
1992 journal article
Effect of cold temperature storage on the stability of benzylpenicillin residues in plasma and tissues of food- producing animals
Journal of the Association of Official Analytical Chemists International, 75(6), 974–978.
Source: NC State University Libraries
Added: April 13, 2019
1991 chapter
Drugs Used in the Treatment of Gastrointestinal Disease
In J. R. August (Ed.), Consultations in Feline Internal Medicine (pp. 463–469). Philadelphia: W.B. Saunders Company.
Ed(s): J. August
Source: NC State University Libraries
Added: April 13, 2019
1991 journal article
Keeping current on developments in antimicrobial therapy
Veterinary Medicine, 600–609.
Source: NC State University Libraries
Added: April 13, 2019
1991 journal article
Performance of Five Screening Tests for the Detection of Penicillin G Residues in Experimentally Injected Calves
Journal of Food Protection, 54(1), 37–40.
TL;DR:
The BBRT and Charm Test II appear to offer greater sensitivity for penicillin G residues than such currently used procedures as STOP and CAST but should be confirmed by a suitable laboratory method, such as the HPLC procedure used in this study.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: March 2, 2019
1991 journal article
Therapeutic Drug Monitoring: A Realistic Assessment
Veterinary Medicine Report, 3(2), 165–171.
Source: NC State University Libraries
Added: April 13, 2019
1990 journal article
Medical Therapy for Gastrointestinal Ulceration in Foals
Compendium on Continuing Education for the Practicing Veterinarian, 12(3), 403–413.
Source: NC State University Libraries
Added: April 13, 2019
1990 journal article
Pharmacological Relaxation of the Urethra in Male Cats: A Study of the Effects of Phenoxybenzamine, Diazepam, Nifedipine, and Xylazine
Canadian Journal of Veterinary Research, 55, 28–32.
Source: NC State University Libraries
Added: April 13, 2019
1990 journal article
Tissue Concentrations of Antimicrobials: The Site of Action
Problems in Veterinary Medicine, 2(2), 312–329.
Source: NC State University Libraries
Added: April 13, 2019
1990 journal article
Toxicoses from Over-the-Counter Human Drugs
Veterinary Clinics of North America: Small Animal Practice, 20(2), 431–451.
MeSH headings : Animals; Cat Diseases / chemically induced; Cats; Dog Diseases / chemically induced; Dogs; Humans; Nonprescription Drugs / poisoning
TL;DR:
Drug groups discussed are cough, cold, and allergy medications, laxatives and cathartics, antacids, antidiarrheal agents, topicals, and vitamin and iron supplements.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: March 2, 2019
1989 journal article
Antiulcer Therapy
Veterinary Medicine Report, 1(3), 309–320.
Source: NC State University Libraries
Added: April 13, 2019
1989 journal article
Clinical and Pathological Effects of Flunixin Meglumine Administration to Neonatal Foals
Canadian Journal of Veterinary Research, 53(2), 195–201.
Source: NC State University Libraries
Added: April 13, 2019
1989 chapter
Complications of Cardiopulmonary Drug Therapy
In R. W. Kirk (Ed.), Current Veterinary Therapy (10th ed., pp. 308–315). Philadelphia: W.B. Saunders Company.
Ed(s): R. Kirk
Source: NC State University Libraries
Added: April 13, 2019
1989 chapter
Effects of Drugs on Pregnancy
In R. W. Kirk (Ed.), Current Veterinary Therapy (10th ed., pp. 1291–1298). Philadelphia: W.B. Saunders Company.
Ed(s): R. Kirk
Source: NC State University Libraries
Added: April 13, 2019
1989 chapter
Glucocorticoid Therapy
In R. W. Kirk (Ed.), Current Veterinary Therapy (10th ed., pp. 54–62). Philadelphia: W.B. Saunders Company.
Ed(s): R. Kirk
Source: NC State University Libraries
Added: April 13, 2019
1989 chapter
Medical Therapy of Gastrointestinal Ulcers
In R. W. Kirk (Ed.), Current Veterinary Therapy (10th ed., pp. 911–917). Philadelphia: W.B. Saunders Company.
Ed(s): R. Kirk
Source: NC State University Libraries
Added: April 13, 2019
1989 chapter
Non-steroidal Anti-inflammatory Drugs
In R. W. Kirk (Ed.), Current Veterinary Therapy (10th ed., pp. 47–53). Philadelphia: W.B. Saunders Company.
Ed(s): R. Kirk
Source: NC State University Libraries
Added: April 13, 2019
1989 journal article
The Protective Effects of Sucralfate and Ranitidine in Foals Experimentally Intoxicated with Phenylbutazone
Canadian Journal of Veterinary Research, 53(2), 231–238.
Source: NC State University Libraries
Added: April 13, 2019
1988 journal article
Therapy of Gram-Positive Bacterial Infections
Veterinary Clinics of North America: Small Animal Practice, 18(6), 1267–1285.
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Bacterial Infections / drug therapy; Bacterial Infections / veterinary; Cat Diseases / drug therapy; Cats; Dog Diseases / drug therapy; Dogs; Gram-Positive Bacteria
TL;DR:
This article considers the important features of gram-positive bacteria that relate to chemotherapy and the clinical pharmacology of the drugs of choice for treating these infections.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: February 27, 2019
1987 journal article
Absorption of Salicylate from an Anti-diarrheal Preparation in Dogs and Cats
Journal of American Animal Hospital Association, 23, 221–226.
Source: NC State University Libraries
Added: April 13, 2019
1987 journal article
Acute Renal Failure in Dogs: A case of Gentamicin Toxicity
Compendium for Continuing Education for the Practicing Veterinarian, 9, 510–520.
Source: NC State University Libraries
Added: April 13, 2019
1987 journal article
The Beta-Lactam Antibiotics: Clinical Pharmacology and Recent Developments
Compendium for Continuing Education, 9, 68–76.
Source: NC State University Libraries
Added: April 13, 2019
1986 chapter
Bronchodilator Therapy
In R. W. Kirk (Ed.), Current Veterinary Therapy (9th ed., pp. 278–284). Philadelphia: W.B. Saunders Company.
Ed(s): R. Kirk
Source: NC State University Libraries
Added: April 13, 2019
1986 journal article
Current Concepts in Pulmonary Pharmacology
Seminars in Veterinary Medicine and Surgery: Small Animal, 1, 289–301.
Source: NC State University Libraries
Added: April 13, 2019
1986 journal article
Drug Therapy During Pregnancy and in the Neonate
Veterinary Clinics of North America: Small Animal Practice, 16(3), 525–538.
MeSH headings : Abnormalities, Drug-Induced / veterinary; Animals; Animals, Newborn; Drug-Related Side Effects and Adverse Reactions; Embryo, Mammalian / drug effects; Female; Fetus / drug effects; Humans; Maternal-Fetal Exchange; Placenta / physiology; Pregnancy; Pregnancy Complications / drug therapy; Pregnancy Complications / veterinary; Pregnancy, Animal
TL;DR:
This article presents important clinical pharmacologic aspects of drug therapy during pregnancy and reviews the potential adverse effects on the mother and conceptus caused by drugs and includes specific recommendations for therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: February 27, 2019
1986 journal article
Pharmacokinetics of Procainamide in Dogs
American Journal of Veterinary Research, 47, 2351–2358.
Source: NC State University Libraries
Added: April 13, 2019
1986 journal article
Procainamide in the Dog: Antiarrhythmic Plasma Concentrations after Intravenous Administration
Journal of Veterinary Pharmacology and Therapeutics, 9, 359–369.
MeSH headings : Animals; Arrhythmias, Cardiac / chemically induced; Arrhythmias, Cardiac / drug therapy; Arrhythmias, Cardiac / veterinary; Computer Simulation; Dog Diseases / drug therapy; Dogs; Electrocardiography; Female; Infusions, Intravenous; Injections, Intravenous; Kinetics; Male; Ouabain; Procainamide / administration & dosage; Procainamide / blood; Procainamide / therapeutic use
TL;DR:
Data may suggest that plasma concentrations of procainamide for controlling some cardiac arrhythmias in dogs may be higher than plasma concentrations cited for human patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID
Added: April 13, 2019
1985 journal article
Drugs and the Liver
Veterinary Clinics of North America (Small Animal Practice), 15(1), 63–81.
Source: NC State University Libraries
Added: April 13, 2019
1985 chapter
Pharmacokinetics for Some Antimicrobials Used in Small Animals
In W. Guin (Ed.), Veterinary Values (2nd ed., pp. 203–207). New York: Ag. Resources, Inc.
Ed(s): W. Guin
Source: NC State University Libraries
Added: April 13, 2019
1984 journal article
Clinical Pharmacology of Cephalosporin Antibiotics
Journal of the American Veterinary Medical Association, 184(3), 344–347.
Source: NC State University Libraries
Added: April 13, 2019
Employment
Updated: August 4th, 2014 18:49
1993 - present
North Carolina State University Raleigh, NC, US
Professor
College of Veterinary Medicine
Education
Updated: June 6th, 2017 21:52
North Carolina State University Raleigh, NC, US
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