@article{hobbs_davis_cooper_ueda_burke_sheats_2024, title={Hemadsorption extracorporeal therapy removes cytokines ex vivo in horses}, volume={85}, ISSN={["1943-5681"]}, DOI={10.2460/ajvr.24.01.0022}, abstractNote={Plasma cytokine adsorption has shown benefit as an adjunctive therapy in human sepsis but has yet to be investigated in horses. We hypothesized that ex vivo filtration of equine plasma with a novel cytokine adsorption device would significantly reduce concentrations of lipopolysaccharide-stimulated cytokines. We also hypothesized that the device would adsorb medications commonly used to treat sepsis.8 horses owned by North Carolina State University.Four liters of heparinized whole blood was collected from healthy adult horses (n = 8) and stimulated with lipopolysaccharide (100 ng/mL) for 6 hours (37 °C.) from June 4, 2023, to December 15, 2023. Plasma was filtered through a cytokine adsorption device or sham circuit. Samples were collected at 11 time points for multiplex cytokine analysis. Chemistry analysis was performed before and after filtration. To investigate the impact of the device on medication concentrations, equine plasma containing potassium penicillin, gentamicin, and flunixin meglumine was filtered through the cytokine adsorption device or sham for 6 hours. Drug concentrations before and after filtration were determined by ultra-high-performance liquid chromatography. Prefiltration versus postfiltration sample concentrations were analyzed by Student paired t test using GraphPad Prism 9.0 (P < .05).Filtration of lipopolysaccharide-stimulated equine plasma (n = 8) for 6 hours resulted in significant mean reductions in the cytokines IL-10, IL-5, IL-8, tumor necrosis factor-α (TNF-α), and IL-1β, as well as albumin. Drug concentrations of potassium penicillin, gentamicin, and flunixin meglumine were also significantly reduced by filtration.This work provides proof of concept for further investigation of extracorporeal cytokine adsorption as a potential adjunct treatment for equine sepsis.}, number={6}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Hobbs, Kallie J. and Davis, Jennifer L. and Cooper, Bethanie L. and Ueda, Yu and Burke, Megan J. and Sheats, Katie}, year={2024}, month={Jun} }
 @article{ruff_zetterstrom_boone_hofmeister_smith_epstein_blikslager_fogle_burke_2023, title={Retrospective analysis of postoperative complications following surgical treatment of ileal impaction in horses managed with manual decompression compared to jejunal enterotomy}, volume={10}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2023.1156678}, abstractNote={ObjectiveThe objective of this study was to compare the occurrence of post-operative complications and survival to discharge in horses with ileal impactions resolved by manual decompression compared with jejunal enterotomy.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Ruff, Jennifer and Zetterstrom, Sandra and Boone, Lindsey and Hofmeister, Erik and Smith, Caitlin and Epstein, Kira and Blikslager, Anthony and Fogle, Callie and Burke, Megan}, year={2023}, month={Apr} }
 @article{murillo_ramaker_burke_walker_negrao watanabe_2023, title={Severe unilateral nephrolithiasis and recurrent colic in a horse}, volume={1}, ISSN={["2052-6121"]}, url={http://dx.doi.org/10.1002/vrc2.567}, DOI={10.1002/vrc2.567}, abstractNote={Abstract}, journal={VETERINARY RECORD CASE REPORTS}, publisher={Wiley}, author={Murillo, Daniel Felipe Barrantes and Ramaker, Erica and Burke, Megan and Walker, Ryan and Negrao Watanabe, Tatiane Terumi}, year={2023}, month={Jan} }
 @article{sheats_burke_robertson_fiebrandt_fogle_2021, title={Development and Formative Evaluation of a Low-Fidelity Equine Castration Model for Veterinary Education}, volume={8}, ISSN={["2297-1769"]}, url={https://europepmc.org/articles/PMC8476848}, DOI={10.3389/fvets.2021.689243}, abstractNote={Entrustable Professional Activities (EPAs) are units of activity that early-stage professionals perform in the workplace that necessitate simultaneous integration of multiple competencies. EPA #6 requires students to perform a common surgical procedure on a stable patient, including pre-operative and post-operative management. Castration is one of the most common surgeries performed by equine primary care practitioners and is considered an “entry-level competency” for veterinary graduates entering equine private practice, however, to our knowledge there are no equine castration models available for veterinary student education. Therefore, we developed an inexpensive, low-fidelity model of equine field castration and evaluated it using a mixed-methods approach. Two different groups of students, with or without model experience, completed surveys before and after live horse castration. Students who used the model also completed model specific surveys. Videos of the students completing the model were evaluated by at least two different equine veterinary faculty using a 15-point rubric, and inter-rater reliability of the rubric was determined. After completing the model, students reflected on strengths and weaknesses of their performance. From our student survey results, we determined that student attitudes toward the model were mostly positive. Interestingly, there were several student attitudes toward the model that became significantly more favorable after live horse castration. Prior to live horse castration, there was no significant difference in confidence in model vs. no-model groups. Following live horse castration, students who used the model had higher confidence in procedure preparation and hand-ties than students who did not use the model, but they had lower scores for confidence during patient recovery. When reflecting on model castration, students most commonly cited preparation and surgical description as strengths, and ligature placement and hand-ties as weaknesses. Experts provided several suggestions to improve the model, including incorporation of emasculators and the need for better model stabilization. Our findings suggest that both students and veterinary educators feel that this low-fidelity model has educational value. Rubric performance metrics were favorable, but additional steps are needed to improve grading consistency among educators. Future research will determine whether student performance on the model is predictive of competence score during live-horse castration.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Sheats, M. Katie and Burke, Megan J. and Robertson, James B. and Fiebrandt, Katherine E. and Fogle, Callie A.}, year={2021}, month={Sep} }
 @article{ziegler_fogle_burke_blikslager_2019, title={Letter to the Editor: Bias in statistics or bias in equine veterinary medicine?}, volume={51}, ISSN={0425-1644 2042-3306}, url={http://dx.doi.org/10.1111/evj.13081}, DOI={10.1111/evj.13081}, abstractNote={See Correspondence by Freeman}, number={3}, journal={Equine Veterinary Journal}, publisher={Wiley}, author={Ziegler, A. L. and Fogle, C. A. and Burke, M. and Blikslager, A. T.}, year={2019}, month={Feb}, pages={423–423} }
 @article{burke_blikslager_2018, title={Advances in Diagnostics and Treatments in Horses with Acute Colic and Postoperative Ileus}, volume={34}, ISSN={0749-0739}, url={http://dx.doi.org/10.1016/j.cveq.2017.11.006}, DOI={10.1016/j.cveq.2017.11.006}, abstractNote={Differentiating between medical and surgical causes of colic is one of the primary goals of the colic workup, because early surgical intervention improves prognosis in horses requiring surgery. Despite the increasing availability of advanced diagnostics (hematologic analyses, abdominal ultrasound imaging, etc), the most accurate indicators of the need for surgery remain the presence of moderate to severe signs of abdominal pain, recurrence of pain after appropriate analgesic therapy, and the absence of intestinal borborygmi. Investigation of novel biomarkers, which may help to differentiate surgical lesions from those that can be managed medically, continues to be an active area of research.}, number={1}, journal={Veterinary Clinics of North America: Equine Practice}, publisher={Elsevier BV}, author={Burke, Megan and Blikslager, Anthony}, year={2018}, month={Apr}, pages={81–96} }
 @article{burke_tomlinson_blikslager_johnson_dallap-schaer_2018, title={Evaluation of digital cryotherapy using a commercially available sleeve style ice boot in healthy horses and horses receiving i.v. endotoxin}, volume={50}, ISSN={["2042-3306"]}, url={https://doi.org/10.1111/evj.12842}, DOI={10.1111/evj.12842}, abstractNote={Summary}, number={6}, journal={EQUINE VETERINARY JOURNAL}, author={Burke, M. J. and Tomlinson, J. E. and Blikslager, A. T. and Johnson, A. L. and Dallap-Schaer, B. L.}, year={2018}, month={Nov}, pages={848–853} }
 @article{ziegler_freeman_fogle_burke_davis_cook_southwood_blikslager_2018, title={Multicentre, blinded, randomised clinical trial comparing the use of flunixin meglumine with firocoxib in horses with small intestinal strangulating obstruction}, volume={51}, ISSN={0425-1644 2042-3306}, url={http://dx.doi.org/10.1111/evj.13013}, DOI={10.1111/evj.13013}, abstractNote={Summary}, number={3}, journal={Equine Veterinary Journal}, publisher={Wiley}, author={Ziegler, A. L. and Freeman, C. K. and Fogle, C. A. and Burke, M. J. and Davis, J. L. and Cook, V. L. and Southwood, L. L. and Blikslager, A. T.}, year={2018}, month={Sep}, pages={329–335} }
 @article{burke_soma_boston_rudy_schaer_2017, title={Evaluation of the analgesic and pharmacokinetic properties of transdermally administered fentanyl in goats.}, url={https://doi.org/10.1111/vec.12644}, DOI={10.1111/vec.12644}, abstractNote={Abstract}, journal={Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)}, author={Burke, MJ and Soma, LR and Boston, RC and Rudy, JA and Schaer, Thomas}, year={2017}, month={Sep} }
 @article{burke_parente_2016, title={Prosthetic Mesh for Obliteration of the Nephrosplenic Space in Horses: 26 Clinical Cases}, volume={45}, ISSN={["1532-950X"]}, url={https://doi.org/10.1111/vsu.12434}, DOI={10.1111/vsu.12434}, abstractNote={ObjectiveTo report surgical complications, occurrence of post‐obliteration colic, long term outcome, and return to previous function for horses treated with prosthetic mesh obliteration of the nephrosplenic space.}, number={2}, journal={VETERINARY SURGERY}, author={Burke, Megan J. and Parente, Eric J.}, year={2016}, month={Feb}, pages={201–207} }
 @article{mackinnon_southwood_burke_palmer_2013, title={Colic in equine neonates: 137 cases (2000-2010).}, url={https://doi.org/10.2460/javma.243.11.1586}, DOI={10.2460/javma.243.11.1586}, abstractNote={Abstract}, journal={Journal of the American Veterinary Medical Association}, author={Mackinnon, MC and Southwood, LL and Burke, MJ and Palmer, JE}, year={2013}, month={Dec} }