Structural and hemodynamic properties of murine pulmonary arterial networks under hypoxia-induced pulmonary hypertension
Chambers, M. J., Colebank, M. J., Qureshi, M. U., Clipp, R., & Olufsen, M. S. (2020, July 28). Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine, Vol. 234, pp. 1312–1329.
author keywords: Pulmonary hypertension; fractal networks; image segmentation; center line extraction; one-dimensional fluid dynamics; Navier-Stokes equations
MeSH headings : Animals; Hemodynamics; Humans; Hypertension, Pulmonary / diagnostic imaging; Hypoxia; Mice; Models, Cardiovascular; Pulmonary Artery / diagnostic imaging; X-Ray Microtomography
topics (OpenAlex): Pulmonary Hypertension Research and Treatments; Cardiovascular Function and Risk Factors; Cardiovascular Health and Disease Prevention
TL;DR:
This study demonstrates how to combine imaging data from microcomputed tomography images with hemodynamic pressure and flow waveforms from control and hypertensive mice to generate subject-specific arterial networks in which one-dimensional fluid dynamics modeling is used to predict blood Pressure and flow.
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