Works (13)
Updated: September 3rd, 2024 08:23
2024 review
Guidelines for mechanistic modeling and analysis in cardiovascular research
[Review of ]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 327(2), H473–H503.
author keywords: computational modeling; mathematical model; model calibration; quantitative biology; simulation
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 26, 2024
2022 article
A computational study of aortic reconstruction in single ventricle patients
Taylor-LaPole, A. M., Colebank, M. J., Weigand, J. D., Olufsen, M. S., & Puelz, C. (2022, November 5). BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, Vol. 11.
author keywords: Hypoplastic left heart syndrome; Fontan circulation; Double outlet right ventricle; Perfusion; Fluid mechanics; Simulation; Systemic circulation
MeSH headings : Humans; Adult; Fontan Procedure / methods; Hemodynamics; Magnetic Resonance Imaging; Hypoplastic Left Heart Syndrome; Aorta
TL;DR:
This study combines the MRA, 4D-MRI, and pressure data with 1D fluid dynamics models to predict hemodynamics in the major systemic arteries, including the cerebral and gut vasculature, to study hypoplastic left heart syndrome patients.
(via Semantic Scholar)
open access via arxiv.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 6, 2022
2022 article
An in-silico analysis of experimental designs to study right ventricular function and pulmonary hypertension
Colebank, M. J., & Chesler, N. C. (2022, March 25). (Vol. 3). Vol. 3.
TL;DR:
An identifiability analysis of a multiscale cardiovascular model including sarcomere dynamics, biventricular interactions, and vascular hemodynamics is considered, and whether parameters could be inferred accurately given limited cardiac data is assessed.
(via Semantic Scholar)
Source: ORCID
Added: March 30, 2022
2022 journal article
An in-silico analysis of experimental designs to study ventricular function: A focus on the right ventricle
PLOS Computational Biology.
Ed(s): A. Marsden
MeSH headings : Heart Ventricles; Humans; Hypertension, Pulmonary; Likelihood Functions; Research Design; Ventricular Dysfunction, Right; Ventricular Function
TL;DR:
A practical identifiability analysis of a multiscale cardiovascular model across four simulated experimental designs shows that model calibration to only RV pressure suffers from practical identIfiability issues and suffers from large forecast uncertainty in output space, but is substantially reduced once additional left ventricular pressure and volume data is included.
(via Semantic Scholar)
Source: ORCID
Added: September 21, 2022
2022 article
Numerical predictions of shear stress and cyclic stretch in pulmonary hypertension due to left heart failure
Bartolo, M. A., Qureshi, M. U., Colebank, M. J., Chesler, N. C., & Olufsen, M. S. (2022, January 17). BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, Vol. 1.
author keywords: Pulmonary hypertension; Micro-circulation; Wall shear stress; Cyclic stretch; Left heart disease; Computational modeling; Pulse wave propagation
MeSH headings : Blood Pressure; Heart Failure / complications; Hemodynamics; Humans; Hypertension, Pulmonary; Pulmonary Artery
TL;DR:
Using a computational fluid dynamics model of the human pulmonary arteries, arterioles, venules, and veins, this model predicts pressure, flow, shear stress, and cyclic stretch that providing a way to analyze and investigate hypotheses related to disease progression in the pulmonary circulation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 17, 2022
2021 journal article
A multiscale model of vascular function in chronic thromboembolic pulmonary hypertension
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 321(2), H318–H338.
author keywords: hemodynamics; mathematical modeling; pulmonary circulation; pulmonary hypertension; wave propagation
MeSH headings : Angioplasty, Balloon; Chronic Disease; Hemodynamics; Humans; Hypertension, Pulmonary / diagnostic imaging; Hypertension, Pulmonary / etiology; Hypertension, Pulmonary / physiopathology; Hypertension, Pulmonary / therapy; Models, Cardiovascular; Models, Theoretical; Pulmonary Artery / diagnostic imaging; Pulmonary Artery / physiopathology; Pulmonary Embolism / complications; Pulmonary Embolism / diagnostic imaging; Pulmonary Embolism / physiopathology; Pulmonary Embolism / therapy
TL;DR:
A multiscale, image-to-hemodynamics pipeline for BPA therapy planning for inoperable CTEPH patients is provided, providing an integrative, holistic tool for identifying optimal target lesions for treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 28, 2021
2020 journal article
Assessing model mismatch and model selection in a Bayesian uncertainty quantification analysis of a fluid-dynamics model of pulmonary blood circulation
Journal of The Royal Society Interface, 17(173), 20200886.
author keywords: uncertainty quantification; model mismatch; model selection; MCMC; Gaussian processes; pulmonary circulation
MeSH headings : Animals; Bayes Theorem; Mice; Nonlinear Dynamics; Pulmonary Circulation; Uncertainty; X-Ray Microtomography
TL;DR:
Bayesian inference is used to quantify the uncertainty of model parameters and haemodynamic predictions in a one-dimensional pulmonary circulation model based on an integration of mouse haemodynamics and micro-computed tomography imaging data and shows that the nonlinear pressure–area relationship with stiffness dependent on the unstressed radius predicts best the data measured in a control mouse.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: December 23, 2020
2020 journal article
Structural and hemodynamic properties of murine pulmonary arterial networks under hypoxia-induced pulmonary hypertension
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE, 234(11), 1312–1329.
author keywords: Pulmonary hypertension; fractal networks; image segmentation; center line extraction; one-dimensional fluid dynamics; Navier-Stokes equations
MeSH headings : Animals; Hemodynamics; Humans; Hypertension, Pulmonary / diagnostic imaging; Hypoxia; Mice; Models, Cardiovascular; Pulmonary Artery / diagnostic imaging; X-Ray Microtomography
TL;DR:
This study demonstrates how to combine imaging data from microcomputed tomography images with hemodynamic pressure and flow waveforms from control and hypertensive mice to generate subject-specific arterial networks in which one-dimensional fluid dynamics modeling is used to predict blood Pressure and flow.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 31, 2020
2019 journal article
Influence of image segmentation on one-dimensional fluid dynamics predictions in the mouse pulmonary arteries
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 16(159).
author keywords: haemodynamics; fluid dynamics; pulmonary circulation; uncertainty quantification; image segmentation
MeSH headings : Algorithms; Animals; Computer Simulation; Hemodynamics; Hypertension, Pulmonary / diagnostic imaging; Hypertension, Pulmonary / physiopathology; Male; Mice; Models, Cardiovascular; Pulmonary Artery / diagnostic imaging; Pulmonary Artery / physiopathology; X-Ray Microtomography
TL;DR:
This study quantifies the variability of one-dimensional CFD predictions by propagating the uncertainty of network geometry and connectivity to blood pressure and flow predictions using multiple segmentations of a single, excised mouse lung.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 3, 2020
2019 journal article
Sensitivity analysis and uncertainty quantification of 1-D models of pulmonary hemodynamics in mice under control and hypertensive conditions
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING, 37(11).
author keywords: computational fluid dynamics; network models; pulmonary hypertension; sensitivity analysis; uncertainty quantification
MeSH headings : Animals; Bayes Theorem; Hemodynamics; Mice; Pulmonary Artery; Uncertainty; X-Ray Microtomography
TL;DR:
Results show that MPA pressure predictions are most sensitive to distal vascular resistance and that parameter influence changes with increasing network complexity, and suggest that PH leads to increased vascular stiffness and decreased peripheral compliance, congruent with clinical observations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 30, 2019
2018 journal article
Hemodynamic assessment of pulmonary hypertension in mice: a model-based analysis of the disease mechanism
Biomechanics and Modeling in Mechanobiology, 18(1), 219–243.
author keywords: Pulmonary hypertension; 1D fluid dynamics model; Linear and nonlinear wall model; Parameter estimation; Statistical model selection; Wave intensity analysis; Impedance analysis
MeSH headings : Animals; Electric Impedance; Hemodynamics; Hypertension, Pulmonary / diagnostic imaging; Hypertension, Pulmonary / physiopathology; Male; Mice, Inbred C57BL; Models, Biological; Nonlinear Dynamics; Pressure; X-Ray Microtomography
TL;DR:
Results show that pulmonary hypertension is associated with stiffer and less compliant proximal and distal vasculature with augmented wave reflections, and that elastic nonlinearities are insignificant in the hypertensive animal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: February 25, 2019
2018 journal article
MCMC methods for inference in a mathematical model of pulmonary circulation
Statistica Neerlandica, 72(3), 306–338.
author keywords: constraint non-linear optimization; delayed rejection adaptive metropolis; pulmonary hypertension; parameter inference; partial differential equations; Windkessel model
TL;DR:
This study uses a fluid dynamics network model that takes selected parameter values and mimics the behaviour of the pulmonary haemodynamics under normal physiological and pathological conditions, and introduces an improved parameter scaling technique in the Delayed Rejection Adaptive Metropolis algorithm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: July 1, 2019
2017 journal article
Characteristic impedance: frequency or time domain approach?
Physiological Measurement, 39(1), 014004.
author keywords: characteristic impedance; blood pressure and flow; pulse wave analysis; impedance analysis; time domain analysis; Fourier methods; large arteries
MeSH headings : Animals; Blood Pressure; Dogs; Electric Impedance; Heart / physiology; Hemodynamics; Humans; Mice; Pulse Wave Analysis; Signal-To-Noise Ratio; Time Factors
TL;DR:
It is shown that the frequency and time domain estimates of Zc are not equally sensitive to certain characteristics of hemodynamic signals including phase lag between pressure and flow, signal to noise ratio and the end of systole retrograde flow.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
Employment
Updated: August 6th, 2024 09:17
2024 - present
University of South Carolina Columbia, South Carolina, US
Assistant Professor
Mathematics
2021 - 2024
University of California, Irvine Irvine, California, US
Postdoctoral Researcher
Biomedical Engineering
Education
Updated: April 15th, 2021 15:09
2016 - 2021
North Carolina State University Raleigh, NC, US
PhD
Biomathematics
Funding History
Funding history based on the linked ORCID record. Updated: March 10th, 2023 12:01
grant
January 1, 2019 - December 21, 2020
Quantification of hemodynamic and geometric parameters in pulmonary hypertension
American Heart Association
grant
August 15, 2015 - June 30, 2024
Institutional Career Development Core
National Center for Advancing Translational Sciences
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