@article{melander_minvielle_melander_2014, title={Controlling bacterial behavior with indole-containing natural products and derivatives}, volume={70}, ISSN={["0040-4020"]}, DOI={10.1016/j.tet.2014.05.089}, abstractNote={Indole has recently been implicated as an important small molecule signal utilized by many bacteria to coordinate various forms of behavior. Indole plays a role in numerous bacterial processes, including: biofilm formation and maintenance, virulence factor production, antibiotic resistance and persister cell formation. Intercepting indole-signaling pathways with appropriately designed small molecules provides a n opportunity to control unwanted bacterial behaviors, and is an attractive anti-virulence therapeutic strategy. In this review, we give an overview of the process controlled by indole signaling, and summarize current efforts to design indole-containing small molecules to intercept these pathways, and detail the synthetic efforts towards accessing indole derived bioactive small molecules.}, number={37}, journal={TETRAHEDRON}, author={Melander, Roberta J. and Minvielle, Marine J. and Melander, Christian}, year={2014}, month={Sep}, pages={6363–6372} }
 @article{minvielle_eguren_melander_2013, title={Highly Active Modulators of Indole Signaling Alter Pathogenic Behaviors in Gram-Negative and Gram-Positive Bacteria}, volume={19}, ISSN={["1521-3765"]}, DOI={10.1002/chem.201303510}, abstractNote={Abstract}, number={51}, journal={CHEMISTRY-A EUROPEAN JOURNAL}, author={Minvielle, Marine J. and Eguren, Kristen and Melander, Christian}, year={2013}, month={Dec}, pages={17595–17602} }
 @article{minvielle_bunders_melander_2013, title={Indole-triazole conjugates are selective inhibitors and inducers of bacterial biofilms}, volume={4}, ISSN={["2040-2511"]}, DOI={10.1039/c3md00064h}, abstractNote={Herein is described a method of accessing indole/triazole and benzothiophene/triazole analogues that selectively promote or inhibit biofilm formation by Gram-positive and Gram-negative bacteria. Structure/function studies revealed that the addition of a bromine atom at the 2-position of the indole/triazole scaffold altered activity against both Gram-negative and Gram-positive bacteria and could transform a biofilm inhibitor into a biofilm inducer. Isosteric replacement of the indole core by a benzothiophene significantly impaired anti-biofilm activity. A competition assay exposing Escherichia coli to the most potent biofilm inducer and an inhibitor of E. coli biofilm formation was performed. The inducer exhibited the ability to mute the effect of the anti-biofilm compound for this targeted bacterial population.}, number={6}, journal={MEDCHEMCOMM}, author={Minvielle, Marine J. and Bunders, Cynthia A. and Melander, Christian}, year={2013}, month={Jun}, pages={916–919} }
 @article{bunders_minvielle_worthington_ortiz_cavanagh_melander_2011, title={Intercepting Bacterial Indole Signaling with Flustramine Derivatives}, volume={133}, ISSN={["1520-5126"]}, DOI={10.1021/ja209836z}, abstractNote={Indole signaling is one of the putative universal signaling networks in bacteria. We have investigated the use of desformylflustrabromine (dFBr) derivatives for the inhibition of biofilm formation through modulation of the indole-signaling network in Escherichia coli and Staphylococcus aureus . We have found dFBr derivatives that are 10-1000 times more active than indole itself, demonstrating that the flustramine family of indolic natural products represent a privileged scaffold for the design of molecules to control pathogenic bacterial behavior.}, number={50}, journal={JOURNAL OF THE AMERICAN CHEMICAL SOCIETY}, author={Bunders, Cynthia A. and Minvielle, Marine J. and Worthington, Roberta J. and Ortiz, Minoshka and Cavanagh, John and Melander, Christian}, year={2011}, month={Dec}, pages={20160–20163} }