Works (112)

Updated: September 8th, 2024 06:46

2024 journal article

Antennal transcriptome analysis reveals sensory receptors potentially associated with host detection in the livestock pest <i>Lucilia cuprina</i>

PARASITES & VECTORS, 17(1).

By: J. Wulff n, P. Hickner*, D. Watson n, S. Denning n, E. Belikoff n & M. Scott n

author keywords: Myiasis; Blowfly livestock pest; Australian sheep blowfly; Host seeking; RNA-Seq; DESeq2; Chemoreceptor; Mechanoreceptor; Antennae
Sources: Web Of Science, NC State University Libraries
Added: July 30, 2024

2024 article

Doxycycline is a viable alternative to tetracycline for use in insect Tet-Off transgenic sexing systems, as assessed in the blowflies Cochliomyia hominivorax and Lucilia cuprina (Diptera: Calliphoridae)

Arp, A. P., Williamson, M. E., Vasquez, M., Quintero, G., Lowman, A. V., Sagel, A., & Scott, M. J. (2024, February 24). (A. Gerry, Ed.). JOURNAL OF ECONOMIC ENTOMOLOGY, Vol. 2.

By: A. Arp, M. Williamson n, M. Vasquez, G. Quintero, A. Lowman*, A. Sagel, M. Scott n

Ed(s): A. Gerry

author keywords: screwworm; transgenic; Tet-Off; tetracycline; sex-lethal
TL;DR: Dox was a suitable antibiotic for mass-rearing Tet-Off female-lethal L. cuprina and C. hominivorax and was functional at much lower dosages than Tc, which could be advantageous in some insect mass-rearing systems. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 1, 2024

2024 journal article

Identification of a gene promoter active in<i> Lucilia</i><i> sericata</i> larval salivary glands using a rapid transient expression assay

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 173.

By: E. Belikoff n, R. Davis n, M. Williamson n, J. Britt n & M. Scott n

author keywords: Salivary gland; Promoter; Maggot therapy; Malpighian tubules; Lucilia sericata
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 1, 2024

2023 journal article

CRISPR/Cas9-based split homing gene drive targeting <i>doublesex for population suppression of the global fruit pest <i>Drosophila suzukii

Proceedings of the National Academy of Sciences, 120(25).

By: A. Yadav n, C. Butler n, A. Yamamoto n, A. Patil n, A. Lloyd n & M. Scott n

author keywords: gene drive; CRISPR; Drosophila suzukii; spotted wing Drosophila; doublesex
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 21, 2023

2023 journal article

Development of transgenic corn planthopper <scp><i>Peregrinus maidis

Insect Molecular Biology, 32(4), 363–375.

By: A. Patil n, W. Klobasa n, D. Espinoza‐Rivera n, O. Baars n, M. Lorenzen n & M. Scott n

TL;DR: The aim of this study was to develop transgenic P. maidis strains that could be used for future genetic biocontrol programs and is the first report of a transgenic Hemiptera. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: March 11, 2023

2023 journal article

Expansion of the genetic toolbox for manipulation of the global crop pest <scp><i>Drosophila suzukii</i></scp>: Isolation and assessment of eye colour mutant strains

Insect Molecular Biology, 10.

By: A. Yadav n, R. Asokan*, A. Yamamoto n, A. Patil n & M. Scott n

author keywords: cinnabar; Drosophila suzukii; sepia; white
TL;DR: The cinnabar, sepia and white mutant strains developed in this study should facilitate future genetic studies in D. suzukii and the development of strains for genetic control of this pest. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: October 30, 2023

2023 journal article

Identification and functional analysis of <i>Cochliomyia hominivorax</i><scp>U6</scp> gene promoters

Insect Molecular Biology, 32(6), 716–724.

author keywords: CRISPR/Cas9; genome editing; pest control; screwworm; U6 promoter
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 10, 2023

2022 journal article

A chromosomal-scale reference genome of the New World Screwworm,<i>Cochliomyia hominivorax

DNA Research, 30(1).

author keywords: Cochliomyia hominivorax; HiC genome; chromosomal assembly; Calliphoridae; ectoparasite
MeSH headings : Animals; Male; Female; Cattle; Calliphoridae; Drosophila melanogaster; Myiasis / veterinary; Screw Worm Infection / veterinary; Chromosomes
TL;DR: A chromosome-scale assembly of C. hominivorax’s genome is presented, organized in 6 chromosome-length and 515 unplaced scaffolds spanning 534 Mb, to provide a basis for future studies aiming at understanding the biology and evolution of this devastating obligate parasite. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: February 13, 2023

2022 chapter book

CRISPR/Cas9 Genome Editing in the New World Screwworm and Australian Sheep Blowfly

By: D. Paulo*, M. Williamson n & M. Scott n

TL;DR: A detailed guide for using the Streptococcus pyogenes Cas9 RNA-guided nuclease to efficiently generate both knockout and knock-in mutations in screwworm and sheep blowfly should accelerate genetic investigations and lead to a better understanding of the roles of selected genes in blowfly development and behavior. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 29, 2024

2022 journal article

Evaluation of Additional Drosophila suzukii Male-Only Strains Generated Through Remobilization of an FL19 Transgene

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 10.

By: A. Yamamoto n, A. Yadav n & M. Scott n

author keywords: Drosophila suzukii; piggyBac transposon; sterile insect technique; spotted wing drosophila; fsRIDL
TL;DR: The aim of this study was to generate additional male-only strains that carried two copies of the FL19 transgene through crossing the original line with a piggyBac jumpstarter strain, and the most promising lines have been selected for future population suppression experiments with strains from different geographical locations. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 6, 2022

2022 journal article

Precision Guided Sterile Males Suppress Populations of an Invasive Crop Pest

GEN Biotechnology, 1(4), 372–385.

By: N. Kandul*, J. Liu*, A. Buchman*, I. Shriner*, R. Corder*, N. Warsinger-Pepe*, T. Yang*, A. Yadav n ...

Contributors: M. Scott n

TL;DR: Precision guided sterile insect technique (pgSIT) utilizes the accuracy of programmable CRISPR gene targeting to generate sterilized males that can be deployed to suppress populations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 29, 2024

2022 chapter book

Transgenic Approaches for Sterile Insect Control of Dipteran Livestock Pests and Lepidopteran Crop Pests

By: M. Scott*, N. Morrison & G. Simmons

Contributors: M. Scott*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 29, 2024

2022 book

Transgenic Insects

In CABI.

Maxwell Scott

Ed(s): M. Benedict & M. Scott

Sources: Crossref, ORCID, NC State University Libraries
Added: November 8, 2023

2021 journal article

A conditional female lethal system for genetic suppression of the global fruit crop pest <scp><i>Drosophila suzukii

Pest Management Science, 77(11), 4915–4922.

By: F. Li n, A. Yamamoto n, E. Belikoff n, A. Berger n, E. Griffith n & M. Scott n

author keywords: Drosophila suzukii; spotted wing Drosophila; sterile insect technique; fsRIDL; tet-OFF; alternate splicing
MeSH headings : Animals; Drosophila / genetics; Fruit; Housing, Animal; Rubus; Suppression, Genetic
TL;DR: It is shown that repeated releases of an excess of transgenic males can suppress D. suzukii populations in laboratory cage trials and suggests that the transgenic strain could provide an effective approach for control of this invasive pest of soft-skinned fruits. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: July 19, 2021

2021 journal article

Conditional knockdown of transformer in sheep blow fly suggests a role in repression of dosage compensation and potential for population suppression

PLOS Genetics, 17(10), e1009792.

By: M. Williamson n, Y. Yan n & M. Scott n

Ed(s): S. Palli

MeSH headings : Animals; Animals, Genetically Modified; Australia; Calliphoridae / genetics; Diptera / genetics; Dosage Compensation, Genetic / genetics; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Female; Genes, Insect / genetics; Genes, X-Linked / genetics; Male; Pupa / genetics; RNA Interference / physiology; RNA Splicing / genetics; RNA-Binding Proteins / genetics; Sheep; Transcription Factors / genetics; X Chromosome / genetics
TL;DR: Results suggest that Lctra promotes somatic sexual differentiation and inhibits X chromosome dosage compensation in female L. cuprina and may be essential for initiation of dosage compensation suppression in female embryos. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: November 15, 2021

2021 journal article

Cover Image, Volume 77, Issue 11

Pest Management Science, 77(11).

By: F. Li, A. Yamamoto, E. Belikoff, A. Berger, E. Griffith & M. Scott*

Source: ORCID
Added: January 29, 2024

2021 journal article

Disruption of the odorant coreceptor Orco impairs foraging and host finding behaviors in the New World screwworm fly

Scientific Reports, 11(1).

By: D. Paulo*, A. Junqueira*, A. Arp*, A. Vieira*, J. Ceballos*, S. Skoda, A. Pérez-de-León*, A. Sagel ...

MeSH headings : Animals; Diptera / metabolism; Diptera / physiology; Feeding Behavior; Host-Seeking Behavior; Insect Proteins / genetics; Insect Proteins / metabolism; Mutation; Phylogeny; Receptors, Odorant / genetics; Receptors, Odorant / metabolism; Smell
TL;DR: It is shown that the screwworm Orco orthologue (ChomOrco) is highly conserved within Diptera, showing signals of strong purifying selection and broadening the understanding of the chemoreception basis of niche occupancy by blowflies. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: June 28, 2021

2021 journal article

Drosophila suzukii</i> (Diptera: Drosophilidae): A Decade of Research Towards a Sustainable Integrated Pest Management Program

Journal of Economic Entomology, 114(5), 1950–1974.

Ed(s): M. Brewer

author keywords: spotted-wing drosophila; integrated pest management; fruit crop; control method
MeSH headings : Animals; Drosophila; Fruit; Insect Control; Insecticides
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: November 23, 2021

2021 journal article

Genetically Encoded CRISPR Components Yield Efficient Gene Editing in the Invasive Pest <i>Drosophila suzukii

The CRISPR Journal, 4(5), 739–751.

Sources: ORCID, Crossref, NC State University Libraries
Added: January 29, 2024

2021 journal article

Genome and transcriptome sequencing of the green bottle fly, Lucilia sericata, reveals underlying factors of sheep flystrike and maggot debridement therapy

Genomics, 113(6), 3978–3988.

By: R. Davis n, E. Belikoff n, A. Dickey n, E. Scholl n, J. Benoit* & M. Scott n

author keywords: Lucilia sericata; Maggot debridement therapy; Whole genome; Salivary gland; Malpighian tubule; Heat shock
MeSH headings : Animals; Calliphoridae; Debridement; Diptera / genetics; Humans; Larva / genetics; Larva / metabolism; Sheep / genetics; Transcriptome
TL;DR: The assembly of a 565.3 Mb genome from long read PacBio DNA sequencing of genomic DNA is reported, which will underpin future genetic studies and in development of engineered strains for genetic control of L. sericata and for biotechnology-enhanced maggot therapy. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: October 26, 2021

2021 journal article

Sex Determination and Dosage Compensation: femaleless Is the Link in Anopheles Mosquitoes

Current Biology, 31(5), R260–R263.

By: M. Scott n

MeSH headings : Animals; Anopheles / genetics; Dosage Compensation, Genetic; Malaria; Mosquito Vectors; X Chromosome / genetics
TL;DR: A new study finds that the femaleless gene is essential for sexual development and repression of X-chromosome dosage compensation in the malaria vector Anopheles gambiae, which could provide the basis for a new genetic approach to control this pest. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: May 3, 2021

2021 journal article

The<i>Aedes aegypti</i>(Diptera: Culicidae)<i>hsp83</i>Gene Promoter Drives Strong Ubiquitous DsRed and ZsGreen Marker Expression in Transgenic Mosquitoes

Journal of Medical Entomology, 58(6), 2533–2537.

By: S. Webster n & M. Scott n

Ed(s): M. Slotman

author keywords: Aedes aegypti; hsp83; fluorescent marker; transgenic mosquito; constitutive promoter
MeSH headings : Aedes / genetics; Aedes / growth & development; Aedes / metabolism; Animals; Animals, Genetically Modified; Genetic Markers; Heat-Shock Proteins / genetics; Heat-Shock Proteins / metabolism; Insect Proteins / genetics; Insect Proteins / metabolism; Larva / growth & development; Larva / metabolism; Luminescent Proteins / metabolism; Promoter Regions, Genetic; Pupa / growth & development; Pupa / metabolism
TL;DR: DsRed and ZsGreen marker genes driven by the constitutive Ae. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: January 18, 2022

2020 journal article

An early female lethal system of the New World screwworm, Cochliomyia hominivorax, for biotechnology-enhanced SIT

BMC Genetics, 21(S2).

By: C. Concha*, Y. Yan*, A. Arp, E. Quilarque, A. Sagel, A. de León*, W. McMillan*, S. Skoda, M. Scott n

author keywords: Transgenic sexing strain; Pest control; Female lethal strain
MeSH headings : Animals; Animals, Genetically Modified; Biotechnology; Diptera / embryology; Diptera / genetics; Embryonic Development; Female; Genes, Lethal; Genetic Fitness; Infertility / genetics; Insect Control; Male; Promoter Regions, Genetic; Tetracycline
TL;DR: The research team demonstrated the utility of biotechnology-enhanced approaches for SIT by developing a male-only strain of the New World Screwworm fly that carried a single component tetracycline repressible female lethal system where females died at late larval/pupal stages. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: January 19, 2021

2020 journal article

Building a transgenic sexing strain for genetic control of the Australian sheep blow fly Lucilia cuprina using two lethal effectors

BMC Genetics, 21(S2).

By: Y. Yan n & M. Scott n

author keywords: Sterile insect technique (SIT); Tetracycline transactivator (tTA); Head involution defective (hid); Genetic pest management
MeSH headings : Animals; Animals, Genetically Modified; Calliphoridae / embryology; Calliphoridae / genetics; Embryonic Development; Female; Genes, Lethal; Genetic Fitness; Insect Control; Sheep / parasitology; Tetracycline / pharmacology
TL;DR: The combination of two tTA-dependent lethal effectors could improve strain stability under mass rearing and could reduce the risk of resistance in the field if fertile males are released. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: January 19, 2021

2020 chapter book

Conditional Expression Systems for Drosophila suzukii Pest Control

By: S. Jaffri*, Y. Yan*, M. Scott n & M. Schetelig*

Sources: Crossref, NC State University Libraries
Added: January 30, 2024

2020 journal article

Core commitments for field trials of gene drive organisms

Science, 370(6523), 1417–1419.

By: K. Long, L. Alphey, G. Annas, C. Bloss, K. Campbell, J. Champer, C. Chen, A. Choudhary ...

Contributors: K. Long, L. Alphey, G. Annas, C. Bloss, K. Campbell, J. Champer, C. Chen, A. Choudhary ...

MeSH headings : Animals; Gene Drive Technology / standards; Guidelines as Topic; Organisms, Genetically Modified; Safety
TL;DR: Significant commitments are outlined that are deemed critical for responsible conduct of a field trial and to ensure that these technologies, if they are introduced, serve the public interest. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: March 22, 2021

2020 journal article

Development and testing of a novel killer–rescue self-limiting gene drive system in <i>Drosophila melanogaster

Proceedings of the Royal Society B: Biological Sciences, 287(1925), 20192994.

By: S. Webster n, M. Vella n & M. Scott n

TL;DR: It is demonstrated that with a single 2:1 engineered to wildtype release, more than 98% of the population carry R after eight generations, and this simple gene drive system could be readily adapted to other species such as mosquito disease vectors for driving anti-viral or anti-parasite genes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 29, 2024

2020 journal article

Genetic Variation and Potential for Resistance Development to the tTA Overexpression Lethal System in Insects

G3 Genes|Genomes|Genetics, 10(4), 1271–1281.

By: K. Knudsen, W. Reid n, T. Barbour, L. Bowes, J. Duncan, E. Philpott, S. Potter, M. Scott n

TL;DR: The data suggest that standing genetic variation in an insect population could provide multiple mechanisms for resistance to the tTA overexpression system, and specifically genes associated with RNA processing and rRNA maturation were significantly upregulated in low lethal lines. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 29, 2024

2020 journal article

Genomic analyses of a livestock pest, the New World screwworm, find potential targets for genetic control programs

Communications Biology, 3(1).

By: M. Scott n, J. Benoit*, R. Davis n, S. Bailey*, V. Varga*, E. Martinson*, P. Hickner*, Z. Syed* ...

MeSH headings : Animals; Calliphoridae / genetics; Calliphoridae / pathogenicity; Evolution, Molecular; Gene Expression Regulation / genetics; Genomics / methods; Host-Parasite Interactions / genetics; Larva / genetics; Larva / growth & development; Livestock / genetics; Livestock / parasitology; Pest Control, Biological; RNA-Seq; Screw Worm Infection / genetics; Screw Worm Infection / parasitology; South America
TL;DR: The genome of the New World screwworm is reported, using transcriptomic analysis of the insect’s developmental stages combined with genomic analyses to identify genes that may be important for its parasitic lifestyle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: September 7, 2020

2020 journal article

Physiological and molecular correlates of the screwworm fly attraction to wound and animal odors

Scientific Reports, 10(1).

By: P. Hickner*, O. Mittapalli*, A. Subramoniam*, A. Sagel, W. Watson n, M. Scott n, A. Arp*, A. de León*, Z. Syed*

MeSH headings : Animals; Behavior, Animal; Diptera / classification; Diptera / drug effects; Diptera / physiology; Female; Gene Expression Regulation; Male; Odorants / analysis; Pheromones / metabolism; Pheromones / pharmacology; RNA-Seq; Wounds and Injuries / metabolism
TL;DR: Insight is provided into the physiological and molecular correlates of the screwworm’s attraction to wounds, and molecular targets that will aid in the development of odorant-based fly management strategies are identified. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: January 4, 2021

2020 journal article

Using Moderate Transgene Expression to Improve the Genetic Sexing System of the Australian Sheep Blow Fly Lucilia cuprina

Insects, 11(11), 797.

By: Y. Yan*, M. Williamson n & M. Scott n

author keywords: livestock pest; Lucilia cuprina; genetic control; pro-apoptotic gene; sterile insect technique; genetic sexing; tetracycline-off system; insect transgenesis
TL;DR: It is shown that effective male-only strains can be made by combining driver/effector lines that have moderate transgene expression/activity, and such a “moderate strategy” could be considered for the TESS development in other pest species. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: December 21, 2020

2019 journal article

Improved transgenic sexing strains for genetic control of the Australian sheep blow fly Lucilia cuprina using embryo-specific gene promoters

Molecular Genetics and Genomics, 295(2), 287–298.

By: Y. Yan n, M. Williamson n, R. Davis n, A. Andere, C. Picard* & M. Scott n

author keywords: Sterile insect technique; Transgenic; Lucilia cuprina; Genetic control; Cellularization gene
MeSH headings : Animals; Animals, Genetically Modified; Australia; Diptera / genetics; Diptera / pathogenicity; Embryonic Development / genetics; Female; Insect Proteins / genetics; Male; Pest Control, Biological; Promoter Regions, Genetic; Sheep / genetics; Sheep / parasitology; Tetracycline / biosynthesis
TL;DR: These new embryonic L. cuprina transgenic sexing strains hold great promise for genetic control programs and the system reported here might also be transferable to other major calliphorid livestock pests such as the New World screwworm, Cochliomyia hominivorax. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: December 2, 2019

2019 journal article

Interplay between Developmental Flexibility and Determinism in the Evolution of Mimetic Heliconius Wing Patterns

Current Biology, 29(23), 3996–4009.e4.

MeSH headings : Animals; Biological Evolution; Biological Mimicry; Butterflies / growth & development; Phenotype; Pigmentation; Selection, Genetic; Wings, Animal / growth & development; Wings, Animal / physiology
TL;DR: The role that the signaling ligand WntA plays in generating mimetic wing patterns in Heliconius butterflies, a group with extraordinary mimicry-related wing pattern diversity, is explored, highlighting a surprising unpredictability in the developmental paths underlying convergence in a recent radiation. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: December 16, 2019

2019 journal article

Specific Gene Disruption in the Major Livestock Pests<i>Cochliomyia hominivorax</i>and<i>Lucilia cuprina</i>Using CRISPR/Cas9

G3 Genes|Genomes|Genetics, 9(9), 3045–3055.

By: D. Paulo*, M. Williamson n, A. Arp*, F. Li n, A. Sagel, S. Skoda, J. Sanchez-Gallego, M. Vasquez ...

author keywords: Functional genomics; reverse genetics; myiasis; New World Screwworm fly; Australian Sheep Blowfly; gene drive; CRISPR; Cas9; brown body; yellow; transformer
MeSH headings : Animals; Animals, Genetically Modified; CRISPR-Cas Systems; Diptera / embryology; Diptera / genetics; Embryo, Nonmammalian; Female; Insect Proteins / genetics; Male; Mutation; Pest Control / methods; RNA, Guide, Kinetoplastida; Sex Determination Processes
TL;DR: The CRISPR protocol described here is a significant improvement on the existing toolkit of molecular methods in calliphorids and suggests that Cas9-based systems targeting Chtra and Lctra could be an effective means for controlling natural populations of these important pests. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: September 23, 2019

2018 journal article

Towards next generation maggot debridement therapy: Transgenic Lucilia sericata larvae that produce and secrete a human growth factor

Wound Repair and Regeneration, 26(1), A27–27.

By: R. Davis, E. Belikoff & M. Scott

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

no blokes Is Essential for Male Viability and X Chromosome Gene Expression in the Australian Sheep Blowfly

Current Biology, 28(12), 1987–1992.e3.

By: R. Davis n, E. Belikoff n, E. Scholl n, F. Li n & M. Scott n

MeSH headings : Animals; Diptera / genetics; Diptera / physiology; Dosage Compensation, Genetic / genetics; Female; Gene Expression; Genes, Insect / genetics; Genes, X-Linked / genetics; Male; X Chromosome / genetics
TL;DR: This study supports the hypothesis on the origin of the Drosophila 4th chromosome and that a POF-like protein was required for normal gene expression on the ancient X chromosome and suggests that NBL could be important for X chromosome dosage compensation in L. cuprina. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2018 journal article

no blokes Is Essential for Male Viability and X Chromosome Gene Expression in the Australian Sheep Blowfly

Current Biology, 28(12), 1987–1992.e3.

By: R. Davis n, E. Belikoff n, E. Scholl n, F. Li n & M. Scott n

Source: ORCID
Added: January 29, 2024

2017 journal article

Agricultural production: assessment of the potential use of Cas9-mediated gene drive systems for agricultural pest control

Journal of Responsible Innovation, 5(sup1), S98–S120.

By: M. Scott n, F. Gould n, M. Lorenzen n, N. Grubbs n, O. Edwards* & D. O’Brochta*

author keywords: Gene drive; Cas9; sterile insect technique; agricultural pest insect
TL;DR: To highlight how gene drives could be useful for control of agricultural insect pests, species that are pests of animals, plants, and animals are selected. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Building early-larval sexing systems for genetic control of the Australian sheep blow fly Lucilia cuprina using two constitutive promoters

Scientific Reports, 7(1).

By: Y. Yan n, R. Linger n & M. Scott n

MeSH headings : Animals; Animals, Genetically Modified; Australia; Diptera / genetics; Diptera / growth & development; Diptera / metabolism; Embryo, Nonmammalian; Female; Genes, Insect; Genes, Lethal; Larva / genetics; Larva / growth & development; Larva / metabolism; Male; Pest Control, Biological / methods; Promoter Regions, Genetic; Sex Differentiation; Sheep / parasitology; Sheep Diseases / prevention & control; Tetracycline / pharmacology; Transcriptional Activation / drug effects
TL;DR: Investigating the idea of isolating and employing the promoters from the Lucilia spitting image and actin 5C genes to drive tTA expression in embryos and later stages found it to be effective for assembling an effective TSS. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Review of research advances in the screwworm eradication program over the past 25 years

Entomologia Experimentalis Et Applicata, 164(3), 226–236.

By: M. Scott n, C. Concha*, J. Welch*, P. Phillips* & S. Skoda*

author keywords: New World screwworm; Cochliomyia hominivorax; Diptera; Calliphoridae; Chrysomyinae; sterile insect technique; SIT; insect mass rearing; obligate myiasis; insect genetics; male-only strains; insect surveillance
TL;DR: The ability to release only sterile males, which has been a goal of the program for over 60 years, has recently been accomplished through the development of transgenic sexing strains that are comparable to the wild‐type strain for several biological parameters that are important for mass production and performance in the field. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

The potential for the use of gene drives for pest control in New Zealand: a perspective

Journal of the Royal Society of New Zealand, 48(4), 225–244.

author keywords: Bioheritage; bioprotection; CRISPR; gene drives; pest control; social licence
TL;DR: The current state of gene drive technologies is described and a series of examples are presented to examine the potential benefits and problems arising from gene drive approaches for pest control in New Zealand. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Crossref, NC State University Libraries
Added: November 22, 2020

2016 journal article

A blow to the fly — Lucilia cuprina draft genome and transcriptome to support advances in biology and biotechnology

Biotechnology Advances, 34(5), 605–620.

author keywords: Lucilia; Blow fly; Genome; Transcriptome; Molecular biology
MeSH headings : Animals; Biotechnology; Diptera / drug effects; Diptera / genetics; Diptera / physiology; Genome, Insect; Insecticide Resistance; Insecticides; Myiasis / prevention & control; Myiasis / transmission; Transcriptome
TL;DR: A perspective on the impact that the L. cuprina genome should have on future research of this and related parasitic flies, and the design of new and improved interventions for myiasis is provided. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

A transgenic male-only strain of the New World screwworm for an improved control program using the sterile insect technique

BMC Biology, 14(1).

By: C. Concha n, A. Palavesam, F. Guerrero*, A. Sagel, F. Li n, J. Osborne n, Y. Hernandez*, T. Pardo ...

TL;DR: It is concluded that the promising characteristics of the selected sexing strains may contribute to reduce production costs for the existing eradication program and provide more efficient population suppression, which should make a genetic control program more economical in regions were C. hominivorax remains endemic. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

A transgenic male-only strain of the New World screwworm for an improved control program using the sterile insect technique

BMC Biology, 14(1), 72.

By: C. Concha, A. Palavesam, F. Guerrero, A. Sagel, F. Li, J. Osborne, Y. Hernandez, T. Pardo ...

Source: ORCID
Added: January 29, 2024

2016 journal article

CRISPR/Cas9-mediated mutagenesis of the white and Sex lethal loci in the invasive pest, Drosophila suzukii

Biochemical and Biophysical Research Communications, 469(4), 911–916.

By: F. Li n & M. Scott n

author keywords: Drosophila suzukii; CRISPR; Cas9; white; Sex-lethal
MeSH headings : ATP-Binding Cassette Transporters / genetics; Animals; CRISPR-Cas Systems / genetics; Clustered Regularly Interspaced Short Palindromic Repeats / genetics; Drosophila / classification; Drosophila / genetics; Drosophila Proteins / genetics; Eye Color / genetics; Eye Proteins / genetics; Female; Male; Mutagenesis, Site-Directed / methods; Quantitative Trait Loci / genetics; RNA-Binding Proteins / genetics; Sex Characteristics
TL;DR: The D. suzukii Sxl gene could be an excellent target for a Cas9-mediated gene drive to suppress populations of this highly destructive pest. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2016 chapter book

Concept and History of Genetic Control

By: M. Scott n & M. Benedict

TL;DR: This chapter provides highlights of the development of genetic control of agricultural pests and describes how the developed methods against mosquitoes reflects those advances, and suggests that much can also be learned from both past successful and failed efforts as doing so will increase the ability to improve future activities. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: January 30, 2024

2016 journal article

Concept and history of genetic control

Genetic Control of Malaria and Dengue, 31–54.

By: M. Scott & M. Benedict

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Long-Term Memory in<i>Drosophila</i>Is Influenced by Histone Deacetylase HDAC4 Interacting with SUMO-Conjugating Enzyme Ubc9

Genetics, 203(3), 1249–1264.

author keywords: histone deacetylase; SUMOylation; plasticity; neuron; memory
MeSH headings : Animals; Brain / growth & development; Brain / metabolism; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Gene Expression Regulation, Developmental / genetics; Histone Deacetylases / genetics; Histone Deacetylases / metabolism; Memory, Long-Term; RNA Interference; Sumoylation / genetics; Ubiquitin-Conjugating Enzymes / genetics; Ubiquitin-Conjugating Enzymes / metabolism
TL;DR: RNA interference-induced reduction of Ubc9 in the adult brain impaired long-term memory in the courtship suppression assay, a Drosophila model of associative memory, and it is demonstrated that HDAC4 and Ubc 9 interact genetically during memory formation, opening new avenues for investigating the mechanisms through whichHDAC4 regulates memory formation and other neurological processes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Towards next generation maggot debridement therapy: transgenic Lucilia sericata larvae that produce and secrete a human growth factor

BMC Biotechnology, 16(1).

author keywords: Maggot debridement therapy (MDT); Platelet-derived growth factor (PDGF); Excretions/secretions (ES); Growth factor treatment; Diabetic foot ulcer; Tetracycline transactivator; Lucilia sericata; Wound healing
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

A transgenic embryonic sexing system for the Australian sheep blow fly Lucilia cuprina

Scientific Reports, 5(1).

By: Y. Yan n & M. Scott n

MeSH headings : Animals; Animals, Genetically Modified / genetics; Australia; Diptera / drug effects; Diptera / genetics; Female; Genes, Insect / drug effects; Genes, Insect / genetics; Genes, Lethal / drug effects; Genes, Lethal / genetics; Male; Pest Control, Biological / methods; Pupa / drug effects; Pupa / genetics; Sexual Behavior / physiology; Sheep / parasitology; Tetracycline / pharmacology; Transgenes / drug effects; Transgenes / genetics
TL;DR: Embryonic sexing strains were made by combining the Lsbnk-tTA and tetO-Lshid components into a single gene construct, which will facilitate transfer of the technology to other major calliphorid livestock pests. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2015 chapter

Concept and history of genetic control

In Genetic control of malaria and dengue (pp. 31–54). Elsevier.

By: M. Scott & M. Benedict

Source: ORCID
Added: January 29, 2024

2015 journal article

Dosage Compensation of X-Linked Muller Element F Genes but Not X-Linked Transgenes in the Australian Sheep Blowfly

PLOS ONE, 10(10), e0141544.

By: R. Linger n, E. Belikoff n & M. Scott n

Ed(s): G. Marais

MeSH headings : Animals; Animals, Genetically Modified; Diptera / genetics; Dosage Compensation, Genetic; Drosophila melanogaster / genetics; Female; Gene Expression Regulation, Developmental; Genes, X-Linked / genetics; Larva; Male; X Chromosome / genetics
TL;DR: It appears that the Lucilia dosage compensation system is specific for genes endogenous to the X chromosome and cannot be co-opted by recently arrived transgenes. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2014 journal article

Control of the sheep blowfly in Australia and New Zealand – are we there yet?

International Journal for Parasitology, 44(12), 879–891.

By: R. Sandeman*, G. Levot*, A. Heath*, P. James*, J. Greeff*, M. Scott n, P. Batterham, V. Bowles*

author keywords: Lucilia cuprina; Drug resistance; Biological control; Vaccines; Sheep resistance; Genetics
MeSH headings : Animals; Australia; Diptera / genetics; Diptera / immunology; Diptera / physiology; Insect Control / methods; Insect Control / trends; Insecticide Resistance; Insecticides; Larva; Myiasis / immunology; Myiasis / prevention & control; Myiasis / veterinary; New Zealand; Pest Control, Biological; Sheep; Sheep Diseases / immunology; Sheep Diseases / prevention & control; Vaccines
TL;DR: The last 50 years of research into infections in Australia and New Zealand caused by larvae of the sheep blowfly, Lucilia cuprina, have significantly advanced the authors' understanding of this blowfly and its primary host, the sheep. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2014 journal article

Control of the sheep blowfly in Australia and New Zealand--are we there yet?

International Journal for Parasitology, 44(12), 879–891.

By: R. Sandeman, G. Levot, A. Heath, P. James, J. Greeff, M. Scott, P. Batterham, V. Bowles

Source: ORCID
Added: January 29, 2024

2014 journal article

Development and evaluation of male-only strains of the Australian sheep blowfly, Lucilia cuprina

BMC Genomic Data, 15(S2).

By: M. Scott n

MeSH headings : Animals; Animals, Genetically Modified; Diptera / genetics; Female; Gene Expression Regulation; Genes, Insect; Genes, Lethal; Germ Cells; Male; Organ Specificity / genetics; Transformation, Genetic
TL;DR: Research on tetracycline-repressible female lethal genetic systems, Lucilia germ-line transformation and sex determination genes that ultimately led to the successful development of transgenic "male-only" strains of L. cuprina are reviewed. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2014 journal article

Functional characterization of calliphorid cell death genes and cellularization gene promoters for controlling gene expression and cell viability in early embryos

Insect Molecular Biology, 24(1), 58–70.

By: R. Edman n, R. Linger n, E. Belikoff n, F. Li n, S. Sze*, A. Tarone*, M. Scott n

author keywords: genetic sexing; transgenic; cellularization gene; sterile insect technique
MeSH headings : Amino Acid Sequence; Animals; Animals, Genetically Modified; Base Sequence; Cell Death / genetics; Cell Survival; Diptera / embryology; Diptera / genetics; Diptera / growth & development; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Embryo, Nonmammalian; Female; Gene Expression Regulation; Genes, Insect; Genes, Lethal; Male; Molecular Sequence Data; Pest Control, Biological / methods; Promoter Regions, Genetic; Sex Ratio
TL;DR: The isolated gene promoters and pro‐apoptotic genes could potentially be used to build transgenic embryonic sexing strains of calliphorid livestock pests. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2014 journal article

Genome Sequence of the Tsetse Fly ( <i>Glossina morsitans ): Vector of African Trypanosomiasis

Science, 344(6182), 380–386.

By: G. Attardo*, P. Abila, J. Auma, A. Baumann, J. Benoit*, C. Brelsfoard, J. Ribeiro*, J. Cotton ...

TL;DR: The sequence and annotation of the 366-megabase Glossina mors Titans morsitans genome are described, providing a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 2, 2024

2014 journal article

Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis

Science, 344(6182), 380–386.

By: J. Watanabe, M. Hattori, M. Berriman, M. Lehane, N. Hall, P. Solano, S. Aksoy, W. Hide ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis

Science, 344(6182), 380–386.

By: G. Attardo, P. Abila, J. Auma, A. Baumann, J. Benoit, C. Brelsfoard, J. Ribeiro, J. Cotton ...

Source: ORCID
Added: January 29, 2024

2014 journal article

Transgenic approaches for sterile insect control of dipteran livestock pests and lepidopteran crop pests

Transgenic Insects: Techniques and Applications, 152–167.

By: M. Scott, N. Morrison & G. Simmons

Source: NC State University Libraries
Added: August 6, 2018

2014 chapter book

Transgenic approaches for sterile insect control of dipteran livestock pests and lepidopteran crop pests.

By: M. Scott*, N. Morrison & G. Simmons

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: January 30, 2024

2014 chapter

Transgenic approaches for sterile insect control of dipteran livestock pests and lepidopteran crop pests.

In Transgenic Insects: Techniques and Applications (p. 152). CABI.

By: M. Scott, N. Morrison, G. Simmons, M. Benedict & others

Source: ORCID
Added: January 29, 2024

2014 journal article

Transgenic sexing system for genetic control of the Australian sheep blow fly Lucilia cuprina

Insect Biochemistry and Molecular Biology, 51, 80–88.

By: F. Li n, H. Wantuch n, R. Linger n, E. Belikoff n & M. Scott n

author keywords: Sterile insect technique; Transgenic; Lucilia cuprina; Flystrike; Genetic sexing
MeSH headings : Animals; Animals, Genetically Modified; Diptera / genetics; Female; Genes, Insect; Genes, Lethal; Male; Pest Control, Biological / methods; Sex Determination Processes
TL;DR: Transgenic strains of L. cuprina that carry a dominant tetracycline repressible female lethal genetic system are developed and should be readily transferrable to other major calliphorid livestock pests including the New and Old World screwworm. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2013 journal article

Conservation and Sex-Specific Splicing of the transformer Gene in the Calliphorids Cochliomyia hominivorax, Cochliomyia macellaria and Lucilia sericata

PLoS ONE, 8(2), e56303.

By: F. Li n, S. Vensko n, E. Belikoff n & M. Scott n

Ed(s): G. Tear

MeSH headings : Animals; Base Sequence; Conserved Sequence / genetics; Diptera / genetics; Diptera / growth & development; Diptera / physiology; Female; Genes, Insect / genetics; Male; Molecular Sequence Data; Nucleotide Motifs / genetics; RNA Splicing / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sex Characteristics
TL;DR: A model for sex specific regulation of tra splicing is proposed that incorporates the conserved features identified in this study and is proposed to facilitate the development of a “male-only” strain for genetic control programs. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2013 journal article

Sex Determination Mechanisms in the Calliphoridae (Blow Flies)

Sexual Development, 8(1-3), 29–37.

By: M. Scott n, M. Pimsler* & A. Tarone*

author keywords: Calliphoridae; Chrysomya rufifacies; Cochliomyia hominivorax; doublesex; Lucilia cuprina; Sex determination; transformer
MeSH headings : Animals; Base Sequence; Diptera / genetics; Diptera / physiology; Genes, Insect; Models, Genetic; Molecular Sequence Data; RNA Splicing / genetics; Sex Determination Processes
TL;DR: A model that has been proposed for how tra transcripts are sex-specifically spliced in calliphorids is discussed, which is very different from D. melanogaster and L. cuprina. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2013 journal article

Sex determination mechanisms in the Calliphoridae (blow flies)

Sexual Development, 8(1-3), 29–37.

By: M. Scott, M. Pimsler & A. Tarone

Source: ORCID
Added: January 29, 2024

2013 journal article

The Histone Deacetylase HDAC4 Regulates Long-Term Memory in Drosophila

PLoS ONE, 8(12), e83903.

By: H. Fitzsimons*, S. Schwartz*, F. Given* & M. Scott n

Ed(s): E. Skoulakis

MeSH headings : Animals; Drosophila Proteins / biosynthesis; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster; Gene Expression Regulation, Enzymologic / physiology; Gene Knockdown Techniques; Histone Deacetylases / biosynthesis; Histone Deacetylases / genetics; Memory, Long-Term / physiology; Mushroom Bodies / cytology; Mushroom Bodies / enzymology; Myogenic Regulatory Factors / genetics; Myogenic Regulatory Factors / metabolism
TL;DR: It is shown that overexpression of HDAC4 in the adult mushroom body resulted in a specific impairment in long-term courtship memory, but had no affect on short-term memory, suggesting that the repressive effects ofHDAC4 on long- term memory may be through interaction with MEF2. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2012 journal article

A <i>de novo</i> transcriptome assembly of <i>Lucilia sericata</i> (Diptera: Calliphoridae) with predicted alternative splices, single nucleotide polymorphisms and transcript expression estimates

Insect Molecular Biology, 21(2), 205–221.

By: S. Sze*, J. Dunham*, B. Carey*, P. Chang*, F. Li n, R. Edman n, C. Fjeldsted*, M. Scott n, S. Nuzhdin*, A. Tarone*

author keywords: Drosophila; Lucilia; transcriptome; de novo assembly; alternative splice; transposable element
MeSH headings : Alternative Splicing; Animals; Culicidae / genetics; DNA Transposable Elements; Diptera / genetics; Diptera / growth & development; Diptera / metabolism; Drosophila melanogaster / genetics; Female; Gene Expression; Genome, Insect; Male; Molecular Conformation; Multigene Family; Polymorphism, Single Nucleotide; Transcriptome
TL;DR: The assembly of the transcriptome was carried out in a manner that enabled identification of putative single nucleotide polymorphisms (SNPs) and alternative splices, and that provided expression estimates for various life history stages and for salivary tissue. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2012 journal article

Developmental plasticity and the evolution of parasitism in an unusual nematode, Parastrongyloides trichosuri

EvoDevo, 3(1).

By: S. Stasiuk*, M. Scott n & W. Grant*

TL;DR: The role of dauer development in the nematode, Parastrongyloides trichosuri, is investigated, and it is shown that the developmental switch between these life histories is sensitive to the same environmental cues as dauer arrest in free-living nematodes, including sensitivity to a chemical cue produced by the free- living stages. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2012 journal article

Organization and expression of the Australian sheep blowfly (<i>Lucilia cuprina</i>) <i>hsp23</i>, <i>hsp24, hsp70</i> and <i>hsp83</i> genes

Insect Molecular Biology, 21(2), 169–180.

By: C. Concha*, R. Edman*, E. Belikoff*, A. Schiemann, B. Carey & M. Scott*

author keywords: heat shock; hsp70; hsp23; hsp83; Lucilia cuprina; HSF
MeSH headings : Amino Acid Sequence; Animals; Binding Sites; Conserved Sequence; Diptera / genetics; Diptera / growth & development; Diptera / metabolism; Female; Gene Expression; Genes, Insect; Heat-Shock Proteins / genetics; Heat-Shock Proteins / metabolism; Hot Temperature; Insect Proteins / genetics; Insect Proteins / metabolism; Male; Molecular Sequence Data; Phylogeny; Promoter Regions, Genetic; Sequence Alignment
TL;DR: The isolation and characterization of a heat shock protein 70 (hsp70) gene, the hsp83 gene and two genes that encode small Hsps from the Australian sheep blowfly, Lucilia cuprina, a major agricultural pest are reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2011 journal article

Abnormal Dosage Compensation of Reporter Genes Driven by the Drosophila Glass Multiple Reporter (GMR) Enhancer-Promoter

PLoS ONE, 6(5), e20455.

By: C. Laverty*, F. Li*, E. Belikoff* & M. Scott*

Ed(s): A. Bergmann

TL;DR: The gene promoter can affect MSL complex-mediated upregulation and dosage compensation and it appears that the nature of the basal promoter and the presence of binding sites for specific factors influence the ability of a gene promoter to respond to the MSLcomplex. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 29, 2024

2011 journal article

Efficient germ-line transformation of the economically important pest species Lucilia cuprina and Lucilia sericata (Diptera, Calliphoridae)

Insect Biochemistry and Molecular Biology, 41(1), 70–75.

By: C. Concha*, E. Belikoff, B. Carey, F. Li, A. Schiemann & M. Scott*

author keywords: Lucilia cuprina; Lucilia sericata; PiggyBac; Transformation; Transgenesis; Maggot therapy; Flystrike
MeSH headings : Animals; Animals, Genetically Modified / metabolism; Australia; Diptera / genetics; Female; Gene Expression Regulation; Gene Transfer Techniques; Genes, Insect; Germ Cells / metabolism; Green Fluorescent Proteins / analysis; Heat-Shock Proteins / genetics; Heat-Shock Proteins / metabolism; Humans; Larva / genetics; Larva / metabolism; New Zealand; Pest Control, Biological / methods; Plasmids / genetics; Plasmids / metabolism; Sheep; Transformation, Genetic; Transposases / genetics; Transposases / metabolism; Wounds and Injuries / therapy
TL;DR: An efficient and reliable method for germ-line transformation of Lucilia cuprina using new piggyBac vector and helper plasmids containing the strong promoter from the L. cuprina hsp83 gene to drive expression of the transposase and fluorescent protein marker gene is described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2011 journal article

Genetic Modulation of Rpd3 Expression Impairs Long-Term Courtship Memory in Drosophila

PLoS ONE, 6(12), e29171.

By: H. Fitzsimons* & M. Scott n

Ed(s): E. Skoulakis

MeSH headings : Animals; Brain / metabolism; Courtship; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / enzymology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Gene Knockdown Techniques; Histone Deacetylase 1 / genetics; Histone Deacetylase 1 / metabolism; Histone Deacetylases / metabolism; Memory, Long-Term / physiology; Phenotype; RNA Interference; Survival Analysis; Tubulin / metabolism
TL;DR: It is found that while modulation of Rpd3 levels predominantly in the adult mushroom body had no observed impact on immediate recall or one-hour memory, 24-hour LTM was severely impaired and surprisingly, both overexpression as well as RNAi-mediated knockdown of RPD3 resulted in impairment of long-term courtship memory. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2010 journal article

Conservation and sex-specific splicing of the doublesex gene in the economically important pest species Lucilia cuprina

Journal of Genetics, 89(3), 279–285.

By: C. Concha*, F. Li* & M. Scott*

author keywords: doublesex; sex determination; alternative splicing; Lucilia cuprina
MeSH headings : 3' Untranslated Regions / genetics; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Conserved Sequence / genetics; Diptera / genetics; Exons / genetics; Female; Genes, Insect / genetics; Insect Proteins / chemistry; Insect Proteins / genetics; Male; Molecular Sequence Data; RNA Splicing / genetics; Sequence Alignment; Sex Characteristics
TL;DR: The dsx gene (Lcdsx) is isolated from the Australian sheep blowfly and it is found that the LcdsX transcripts are sex-specifically spliced in a similar manner as their counterparts in D. melanogaster, housefly and tephritids. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2010 journal article

Organisation and expression of a cluster of yolk protein genes in the Australian sheep blowfly, Lucilia cuprina

Genetica, 139(1), 63–70.

By: M. Scott n, A. Atapattu*, A. Schiemann*, C. Concha*, R. Henry*, B. Carey*, E. Belikoff n, J. Heinrich*, A. Sarkar*

author keywords: Yolk protein; Sterile insect technique; Lucilia cuprina
MeSH headings : Amino Acid Sequence; Animals; Animals, Genetically Modified / genetics; Australia; Diptera / genetics; Egg Proteins / genetics; Female; Gene Expression Regulation; Genes, Insect; Genetic Vectors; Germ Cells; Male; Molecular Sequence Data; Multigene Family; New Zealand; Sheep / parasitology; Transformation, Genetic; Transgenes
TL;DR: The sequence of a 14.2 kb genomic clone from L. cuprina that contains a cluster of three complete yp genes and one partial yp gene is reported, suggesting the LcypA promoter could be used to obtain female-specific expression of tTA in transgenic L.cuprina. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2010 journal article

Sex-biased transcription enhancement by a 5' tethered Gal4-MOF histone acetyltransferase fusion protein in Drosophila

BMC Molecular Biology, 11(1).

By: A. Schiemann*, F. Li*, V. Weake*, E. Belikoff*, K. Klemmer*, S. Moore*, M. Scott*

MeSH headings : Acetylation; Amino Acid Sequence; Animals; DNA-Binding Proteins / analysis; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Drosophila / enzymology; Drosophila / genetics; Drosophila / metabolism; Drosophila Proteins / analysis; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Female; Genes, Reporter; Genes, X-Linked; Histone Acetyltransferases / analysis; Histone Acetyltransferases / genetics; Histone Acetyltransferases / metabolism; Histones / genetics; Histones / metabolism; Male; Models, Molecular; Molecular Sequence Data; Nuclear Proteins / analysis; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Polytene Chromosomes / chemistry; Recombinant Fusion Proteins / analysis; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Saccharomyces cerevisiae Proteins / analysis; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Sequence Alignment; Sex Factors; Transcription Factors / analysis; Transcription Factors / genetics; Transcription Factors / metabolism; Transcriptional Activation
TL;DR: Targeting MOF to reporter genes led to transcription enhancement and acetylation of histone H4 at lysine 16 and how association of Gal4-MOF with the MSL or NSL proteins could explain the results is discussed. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2010 journal article

Structural and biochemical studies on the chromo-barrel domain of male specific lethal 3 (MSL3) reveal a binding preference for mono-or dimethyllysine 20 on histone H4

Journal of Biological Chemistry, 285(52), 40879–40890.

By: S. Moore, Y. Ferhatoglu, Y. Jia, R. Al-Jiab & M. Scott

Source: ORCID
Added: January 29, 2024

2010 journal article

The importance of location and orientation of male specific lethal complex binding sites of differing affinities on reporter gene dosage compensation in Drosophila

Biochemical and Biophysical Research Communications, 402(4), 699–704.

By: A. Schiemann*, V. Weake, F. Li, C. Laverty, E. Belikoff & M. Scott*

author keywords: Dosage compensation; Epigenetics; MSL complex; Transcription
MeSH headings : 3' Untranslated Regions; Animals; Binding Sites; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Dosage Compensation, Genetic; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Genes, Reporter; Male; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Promoter Regions, Genetic; Transcription Factors / genetics; Transcription Factors / metabolism; Transgenes; beta-Galactosidase / genetics
TL;DR: The results suggest that MSL complex binding to weaker sites and transcription enhancement is influenced by gene transcription, binding site orientation and the local chromatin environment, while strong binding sites do not need to be transcribed to recruit sufficient complex to cause transcription elevation of nearby genes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2009 journal article

Sexual Development in <i>Lucilia cuprina</i> (Diptera, Calliphoridae) Is Controlled by the Transformer Gene

Genetics, 182(3), 785–798.

By: C. Concha* & M. Scott*

TL;DR: The results suggest that an autoregulatory loop sustains female development and that expression of M inhibits LctraAutoregulation, switching its splicing to the male form, shows that this sex determination system is not confined to Tephritidae. (via Semantic Scholar)
Source: Crossref
Added: February 2, 2024

2009 journal article

Sexual development in Lucilia cuprina (Diptera, Calliphoridae) is controlled by the transformer gene

Genetics, 182(3), 785–798.

By: C. Concha & M. Scott

Source: ORCID
Added: January 29, 2024

2008 journal article

How do ncRNAs guide chromatin-modifying complexes to specific locations within the nucleus?

RNA Biology, 5(1), 13–16.

By: M. Scott* & F. Li

TL;DR: Evidence is discussed that ncRNAs function by annealing either with nascent transcripts or with homologous DNA sequences, and a third model is reviewed based on the recent work on the role of the noncoding roX RNAs in the localisation of the MSL complex to sites on the X chromosome in Drosophila. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 29, 2024

2008 journal article

Incorporation of the Noncoding <i>roX</i> RNAs Alters the Chromatin-Binding Specificity of the <i>Drosophila</i> MSL1/MSL2 Complex

Molecular and Cellular Biology, 28(8), 2850–2850.

By: F. Li, A. Schiemann & M. Scott

Sources: Crossref, ORCID
Added: January 29, 2024

2007 journal article

The non-dosage compensated Lsp1α gene of Drosophila melanogaster escapes acetylation by MOF in larval fat body nuclei, but is flanked by two dosage compensated genes

BMC Molecular Biology, 8(1), 35.

By: V. Weake* & M. Scott*

TL;DR: The most likely explanation for why Lsp1 α is not dosage compensated is that the gene has not evolved a mechanism to independently recruit theMSL complex, possibly because of its recent evolutionary origin, and because there appears to be a low level of bound MSL complex in a nearby gene that is active in the same tissue. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 29, 2024

2006 journal article

Insulated piggyBac vectors for insect transgenesis

BMC Biotechnology, 6(1), 27.

By: A. Sarkar*, A. Atapattu, E. Belikoff, J. Heinrich, X. Li, C. Horn, E. Wimmer, M. Scott*

UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, ORCID
Added: January 29, 2024

2005 journal article

Organisation and Expression of a Cluster of Female-specific Genes in the Australian Sheep Blowfly, Lucilia cuprina

Area-Wide Control of Insect Pests.

By: M. Scott, A. Sarkar & E. Belikoff

Source: ORCID
Added: January 29, 2024

2005 journal article

The Amino-Terminal Region of <i>Drosophila</i> MSL1 Contains Basic, Glycine-Rich, and Leucine Zipper-Like Motifs That Promote X Chromosome Binding, Self-Association, and MSL2 Binding, Respectively

Molecular and Cellular Biology, 25(20), 8913–8924.

By: F. Li*, D. Parry* & M. Scott*

TL;DR: It is proposed that the basic region may mediate DNA binding and that the glycine-rich region may promote the association of MSL complexes to closely adjacent sites on the X chromosome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Crossref, ORCID
Added: January 29, 2024

2004 journal article

Progress towards the development of a transgenic strain of the Australian sheep blowfly (Lucilia cuprina) suitable for a male-only sterile release program

Insect Biochemistry and Molecular Biology, 34(2), 185–192.

By: M. Scott, J. Heinrich & X. Li

Source: ORCID
Added: January 29, 2024

2002 journal article

Germ‐line transformation of the Australian sheep blowfly <i>Lucilia cuprina

Insect Molecular Biology, 11(1), 1–10.

By: J. Heinrich*, X. Li*, R. Henry*, N. Haack*, L. Stringfellow*, A. Heath*, M. Scott*

TL;DR: This is the first report of germ‐line transformation of L. cuprina and is an important step towards the generation of engineered strains that would be suitable for male‐only release eradication/suppression programmes. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 29, 2024

2001 journal article

Making 1X=2X: Studies on dosage compensation in Drosophila

NZ BioScience, 9(4), 23–24.

By: M. Scott

Source: NC State University Libraries
Added: February 15, 2024

2001 journal article

Progress towards the development of a transgenic strain of the Australian sheep blowfly suitable for a sterile-release program

NZ BioScience, 9(2), 11–13.

By: M. Scott

Source: NC State University Libraries
Added: February 15, 2024

2001 journal article

Recruitment of the Male-specific Lethal (MSL) Dosage Compensation Complex to an Autosomally Integrated roXChromatin Entry Site Correlates with an Increased Expression of an Adjacent Reporter Gene in Male Drosophila

Journal of Biological Chemistry, 276(34), 31953–31958.

By: R. Henry*, B. Tews*, X. Li* & M. Scott*

TL;DR: This study shows that insertion of either roX1 or roX2 DNA sequences, upstream of an insulated lacZ reporter gene controlled with the constitutive armadillo promoter, results in a significant elevation of expression of lacZ in males. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 29, 2024

2001 journal article

piggyBac-mediated transposition in Drosophila melanogaster: an evaluation of the use of constitutive promoters to control transposase gene expression

Insect Molecular Biology, 10(5), 447–455.

By: X. Li, J. Heinrich & M. Scott

Source: ORCID
Added: January 29, 2024

2001 journal article

piggyBac</i>‐mediated transposition in <i>Drosophila melanogaster</i>: an evaluation of the use of constitutive promoters to control transposase gene expression

Insect Molecular Biology, 10(5), 447–455.

By: X. Li*, J. Heinrich* & M. Scott*

TL;DR: It is shown that plasmids with the piggyBac transposase gene regulated by constitutive promoters can be effective ‘helpers’ for mediating transposition in D. melanogaster. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 2, 2024

2000 journal article

A repressible female-specific lethal genetic system for making transgenic insect strains suitable for a sterile-release program

Proceedings of the National Academy of Sciences, 97(15), 8229–8232.

By: J. Heinrich* & M. Scott*

TL;DR: A tetracycline-repressible female-specific lethal genetic system in the vinegar fly Drosophila melanogaster would be ideal for a sterile-insect release program, which is most effective when only males are released in the field. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 29, 2024

2000 journal article

MSL1 plays a central role in assembly of the MSL complex, essential for dosage compensation in Drosophila

The EMBO Journal, 19(1), 144–155.

By: M. Scott*

TL;DR: It is concluded that a main role of MSL1 is to serve as the backbone for assembly of the MSL complex, and shows similarity to a region of mouse CBP, a transcription co‐activator. (via Semantic Scholar)
Source: Crossref
Added: January 30, 2024

2000 journal article

MSL1 plays a central role in assembly of the MSL complex, essential for dosage compensation in Drosophila

The EMBO Journal, 19(1), 144–155.

By: M. Scott, L. Pan, S. Cleland, A. Knox & J. Heinrich

Source: ORCID
Added: January 29, 2024

1999 journal article

Genetica, 105(3), 215–226.

By: H. Fitzsimons*, R. Henry* & M. Scott*

TL;DR: An insulated reporter system was developed and used to test the hypothesis that some genes could be compensated, at least partially, by Sxl repression in females, suggesting these elements may be rarer than previously thought. (via Semantic Scholar)
Source: Crossref
Added: January 30, 2024

1999 journal article

Development of an insulated reporter system to search for cis-acting DNA sequences required for dosage compensation in Drosophila

Genetica, 105(3), 215–226.

By: H. Fitzsimons, R. Henry & M. Scott

Source: ORCID
Added: January 29, 2024

1999 journal article

Isolation and characterisation of the Drosophila Dror2 gene

NZ BioScience, 7, 17–22.

By: K. Frith & M. Scott

Source: NC State University Libraries
Added: February 15, 2024

1995 journal article

A second superoxide dismutase gene in the medfly, Ceratitis capitata.

Genetics, 140(2), 697–702.

By: G. Banks, A. Robinson, J. Kwiatowski, F. Ayala, M. Scott* & D. Kriticou

TL;DR: Phylogenetic analysis by the maximum parsimony method with bootstrap resampling of previously known Cu/Zn SOD reveals two monophyletic groups, vertebrates and insects, which suggests that the duplication detected in Ceratitis is ancient, perhaps as old as the origins of the arthropod phylum in the Cambrian more than 500 million years ago. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 29, 2024

1995 journal article

Male-specific lethal 2, a dosage compensation gene of Drosophila, undergoes sex-specific regulation and encodes a protein with a RING finger and a metallothionein-like cysteine cluster.

The EMBO Journal, 14(12), 2884–2895.

By: S. Zhou*, Y. Yang*, M. Scott*, A. Pannuti*, K. Fehr*, A. Eisen*, E. Koonin*, D. Fouts* ...

TL;DR: The observations suggest that MSL‐2 may be the target of the master regulatory gene Sxl and provide the basic elements of a working hypothesis on the function of MSl‐2 in mediating the 2‐fold increase in transcription that is characteristic of dosage compensation. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 29, 2024

1993 journal article

Isolation of cDNAs encoding 6‐phosphogluconate dehydrogenase and glucose‐6‐phosphate dehydrogenase from the mediterranean fruit fly <i>Ceratitis capitata</i>: correlating genetic and physical maps of chromosome 5

Insect Molecular Biology, 1(4), 213–222.

By: M. Scott*, D. Kriticou* & A. Robinson*

TL;DR: The codon usage of the cDNA clones has little bias with the notable exceptions of arginine, glycine and leucine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, ORCID
Added: January 29, 2024

1991 journal article

Structure and expression of the Drosophila melanogaster gene encoding 6-phosphogluconate dehydrogenase

Gene, 109(2), 177–183.

By: M. Scott* & J. Lucchesi

TL;DR: The results indicate that the large second intron is critical for Pgd+ expression in adults, and only 421 bp of Pgd- 5'-flanking DNA are necessary to direct expression in imaginal discs, gonads and gut of third-instar larvae. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 29, 2024

1990 chapter

Intervening sequences in molecular evolution

In Intervening Sequences in Evolution and Development (pp. 92–111). Oxford University Press.

By: J. Stein, M. Scott & B. O’Malley

Source: ORCID
Added: January 29, 2024

1987 conference paper

DNASE I SENSITIVITY OF THE OVOMUCOID-OVOINHIBITOR GENE-COMPLEX IN OVIDUCT NUCLEI AND RELATIVE LOCATION OF CR-1 REPETITIVE SEQUENCES

JOURNAL OF CELLULAR BIOCHEMISTRY, 91–91.

By: M. Scott, M. Tsai & B. Omalley

Event: WILEY-LISS DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012

Source: ORCID
Added: January 29, 2024

1987 journal article

Deoxyribonuclease I sensitivity of the ovomucoid-ovoinhibitor gene complex in oviduct nuclei and relative location of CR1 repetitive sequences

Biochemistry, 26(21), 6831–6840.

By: M. Scott*, M. Tsai & B. O'Malley

TL;DR: The noncoding strand of sequences within and immediately adjacent to the 5' end of the actively transcribed ovomucoid and ovalbumin genes was less sensitive to DNase I digestion than their respective coding strands. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 29, 2024

1987 journal article

Ovoinhibitor introns specify functional domains as in the related and linked ovomucoid gene.

Journal of Biological Chemistry, 262(12), 5899–5907.

By: M. Scott*, C. Huckaby, I. Kato, W. Kohr, M. Laskowski, M. Tsai, B. O'Malley

TL;DR: The location of the intradomain intron in relation to the known structure of four Kazal inhibitors and suggest a scheme for the evolution of the ovoinhibitor gene are discussed. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 29, 2024

1986 book

Higher order chromatin structure of the ovomucoid-ovoinhibitor gene complex

Baylor College of Medicine.

By: M. Scott

Source: ORCID
Added: January 29, 2024

1985 chapter

Expression of eukaryotic genes: Transcription and analysis

In W. T. Schrader & B. W. O'Malley (Eds.), Laboratory Methods Manual for Hormone Action and Molecular Endocrinology (pp. 13 1–13 4). Houston Biological Assoc. Inc.

By: M. Tsai, S. Tsai, M. Baez, F. Simmen, M. Scott & B. O'Malley

Ed(s): W. Schrader & B. O'Malley

Source: NC State University Libraries
Added: February 15, 2024

1985 chapter

Expression of eukaryotic genes: Transcription and analysis

In W. T. Schrader & B. W. O'Malley (Eds.), Laboratory Methods Manual for Hormone Action and Molecular Endocrinology (pp. 13 1–13 4). Houston Biological Assoc. Inc.

By: M. Tsai, S. Tsai, M. Baez, F. Simmen, M. Scott & B. O'Malley

Ed(s): W. Schrader & B. O'Malley

Source: NC State University Libraries
Added: February 15, 2024

1985 chapter

Nuclear matrix: Relationship to DNase I sensitivity and transcriptional activity

In E. A. Smuckler & G. A. Clawson (Eds.), UCLA Symposia "Nuclear Envelope Structure and RNA Maturation (Vol. 26, pp. 87–97). New York: Alan R. Liss, Inc.

By: C. Huckaby, E. Ciejek, M. Scott, M. Alevy, M. Tsai & B. O'Malley

Ed(s): E. Smuckler & G. Clawson

Source: NC State University Libraries
Added: February 15, 2024

1985 journal article

The structural organization of the chicken calmodulin gene.

Journal of Biological Chemistry, 260(2), 907–912.

Maxwell Scott

Source: ORCID
Added: January 29, 2024

Employment

Updated: October 15th, 2019 15:15

2010 - present

North Carolina State University Raleigh, NC, US
Professor Entomology

1993 - 2009

Massey University Palmerston North, NZ
Associate Professor Molecular BioSciences

Education

Updated: January 11th, 2016 11:03

1981 - 1986

Baylor College of Medicine Houston, TX, US
PhD Cell Biology

1977 - 1980

University of Western Australia Crawley, WA, AU
Bachelor of Science (Hons)

Funding History

Funding history based on the linked ORCID record. Updated: August 15th, 2024 17:44

grant September 1, 2024 - August 31, 2027
Development, evaluation and modeling of homing gene drives for suppression of Drosophila and screwworm populations
National Institute of Food and Agriculture
grant September 1, 2021 - August 31, 2024
Assessing the influence of genetic background on the efficacy of Drosophila suzukii male-only and gene drive strains
National Institute of Food and Agriculture
grant January 1, 2021 - December 31, 2025
Dimensions US Sao Paulo: Evolutionary and genetic origins of diverse trophic specializations in blow flies
Directorate for Biological Sciences
grant September 1, 2020 - August 31, 2025
Development and evaluation of Y-linked gene editors for suppression of populations of spotted wing Drosophila and the New World screwworm
National Institute of Food and Agriculture
grant October 1, 2019 - September 30, 2024
Development of novel systems for enhanced genetic control of the New World screwworm
National Institute of Food and Agriculture
grant March 25, 2019 - December 31, 2022
Potential of gene drives to eliminate incursions of Drosophila suzukii
Australian Research Council
grant September 1, 2016 - August 31, 2021
Development and evaluation of safeguards for conditional suppressive gene drives for spotted wing Drosophila and the New World screwworm
National Institute of Food and Agriculture
grant November 19, 2014 - September 30, 2019
Development and evaluation of transgenic insect strains for genetic control programs
National Institute of Food and Agriculture
grant September 1, 2011 - August 31, 2015
An investigation into the potential risks of release of transgenic New World screwworm fly Cochliomyia hominivorax
National Institute of Food and Agriculture
grant January 1, 2010 - September 30, 2014
Development of transgenic insect strains suitable for genetic control programs
National Institute of Food and Agriculture
grant February 28 - August 31, 1989
MOLECULAR ANALYSIS OF THE DROSOPHILA MALE LETHAL 2 LOCUS
National Institute of General Medical Sciences

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