Manuel Kleiner

https://orcid.org/0000-0001-6904-0287

Metaproteomics, Microbiome, Symbiosis, Metagenomics, Microbial Physiology, Carbon Fixation Pathways

Works (50)

2020 journal article

Environmental Viscosity Modulates Interbacterial Killing during Habitat Transition

MBIO, 11(1).

By: L. Speare, S. Smith, F. Salvato, M. Kleiner & A. Septer

Sources: Web Of Science, ORCID
Added: April 6, 2020

2020 journal article

High-Quality Draft Genome Sequences of Two Deltaproteobacterial Endosymbionts, Delta1a and Delta1b, from the Uncultured Sva0081 Clade, Assembled from Metagenomes of the Gutless Marine Worm Olavius algarvensis

MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 9(16).

By: Y. Sato, J. Wippler, C. Wentrup, N. Dubilier & M. Kleiner

Sources: Web Of Science, ORCID
Added: May 8, 2020

2020 journal article

Horizontal acquisition of a patchwork Calvin cycle by symbiotic and free-living Campylobacterota (formerly Epsilonproteobacteria)

ISME JOURNAL, 14(1), 104–122.

By: A. Assie, N. Leisch, D. Meier, H. Gruber-Vodicka, H. Tegetmeyer, A. Meyerdierks, M. Kleiner, T. Hinzke ...

Sources: Web Of Science, ORCID
Added: January 6, 2020

2019 journal article

A shared core microbiome in soda lakes separated by large distances

NATURE COMMUNICATIONS, 10.

By: J. Zorz, C. Sharp, M. Kleiner, P. Gordon, R. Pon, X. Dong, M. Strous

Sources: Web Of Science, ORCID
Added: October 7, 2019

2019 journal article

Chemosynthetic symbiont with a drastically reduced genome serves as primary energy storage in the marine flatworm Paracatenula

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(17), 8505–8514.

By: O. Jaeckle, B. Seah, M. Tietjen, N. Leisch, M. Liebeke, M. Kleiner, J. Berg, H. Gruber-Vodicka

Sources: Web Of Science, ORCID
Added: May 6, 2019

2019 journal article

Comparative proteomics of related symbiotic mussel species reveals high variability of host-symbiont interactions.

The ISME Journal.

Source: ORCID
Added: January 30, 2020

2019 journal article

Genetic evidence for two carbon fixation pathways (the Calvin-Benson-Bassham Cycle and the Reverse Tricarboxylic Acid Cycle) in symbiotic and free-living bacteria

MSphere, 4(1), e00394–18.

By: M. Rubin-Blum, N. Dubilier & M. Kleiner

Sources: NC State University Libraries, Web Of Science, ORCID
Added: February 7, 2019

2019 journal article

Host-Microbe Interactions in the Chemosynthetic Riftia pachyptila Symbiosis.

MBio.

Source: ORCID
Added: January 30, 2020

2019 journal article

Metaproteomics: Much More than Measuring Gene Expression in Microbial Communities

MSYSTEMS, 4(3).

By: M. Kleiner

Sources: Web Of Science, ORCID
Added: September 9, 2019

2019 journal article

More Is Not Always Better: Evaluation of 1D and 2D-LC-MS/MS Methods for Metaproteomics

FRONTIERS IN MICROBIOLOGY, 10.

By: T. Hinzke, A. Kouris, R. Hughes, M. Strous & M. Kleiner

Sources: NC State University Libraries, ORCID
Added: March 4, 2019

2019 journal article

Sulfur-Oxidizing Symbionts without Canonical Genes for Autotrophic CO2 Fixation

MBIO, 10(3).

By: B. Seah, C. Antony, B. Huettel, J. Zarzycki, L. Borzyskowski, T. Erb, A. Kouris, M. Kleiner ...

Sources: Web Of Science, ORCID
Added: July 22, 2019

2019 journal article

Two intracellular and cell type-specific bacterial symbionts in the placozoan Trichoplax H2

NATURE MICROBIOLOGY, 4(9), 1465–1474.

By: H. Gruber-Vodicka, N. Leisch, M. Kleiner, T. Hinzke, M. Liebeke, M. McFall-Ngai, M. Hadfield, N. Dubilier

Sources: Web Of Science, ORCID
Added: September 9, 2019

2018 journal article

Author Correction: Chemosynthetic symbionts of marine invertebrate animals are capable of nitrogen fixation

Nature Microbiology, 3(8), 961–961.

By: J. Petersen, A. Kemper, H. Gruber-Vodicka, U. Cardini, M. van der Geest, M. Kleiner, S. Bulgheresi, M. Mußmann ...

Sources: Crossref, ORCID
Added: January 25, 2020

2018 journal article

Centrifugation-based enrichment of bacterial cell populations for metaproteomic studies on bacteria-invertebrate symbioses

Springer, 1841, 319–334.

By: T. Hinzke, M. Kleiner & S. Markert

Ed(s): D. Becher

Sources: NC State University Libraries, ORCID
Added: February 7, 2019

2018 journal article

Comparative Proteomics of Three Species of Ammonia-Oxidizing Bacteria.

Frontiers in Microbiology.

By: J. Zorz, J. Kozlowski, L. Stein, M. Strous & M. Kleiner

Source: ORCID
Added: February 3, 2019

2018 journal article

Metaproteomics method to determine carbon sources and assimilation pathways of species in microbial communities.

Proceedings of the National Academy of Sciences of the United States of America, 6(24), E5576–5584.

By: M. Kleiner, X. Dong, T. Hinzke, J. Wippler, E. Thorson, B. Mayer, M. Strous

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

Murine colitis reveals a disease-associated bacteriophage community

NATURE MICROBIOLOGY, 3(9), 1023–1031.

By: B. Duerkop, M. Kleiner, D. Paez-Espino, W. Zhu, B. Bushnell, B. Hassell, S. Winter, N. Kyrpides, L. Hooper

Sources: NC State University Libraries, ORCID
Added: October 19, 2018

2018 journal article

Synergy of Sodium Nitroprusside and Nitrate in Inhibiting the Activity of Sulfate Reducing Bacteria in Oil-Containing Bioreactors.

Frontiers in Microbiology, 9.

By: T. Fida, J. Voordouw, M. Ataeian, M. Kleiner, G. Okpala, J. Mand, G. Voordouw

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Assessing species biomass contributions in microbial communities via metaproteomics

Nature Communications, 4.

By: M. Kleiner, E. Thorson, C. Sharp, X. Dong, D. Liu, C. Li, M. Strous

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 article

Assessing species biomass contributions in microbial communities via metaproteomics

Kleiner, M., Thorson, E., Sharp, C. E., Dong, X., Liu, D., Li, C., & Strous, M. (2017, April). (Vol. 4). Vol. 4.

By: M. Kleiner, E. Thorson, C. Sharp, X. Dong, D. Liu, C. Li, M. Strous

Source: ORCID
Added: February 3, 2019

2017 journal article

Fast and Simple Analysis of MiSeq Amplicon Sequencing Data with MetaAmp

Frontiers in Microbiology, 8.

By: X. Dong, M. Kleiner, C. Sharp, E. Thorson, C. Li, D. Liu, M. Strous

Source: ORCID
Added: February 3, 2019

2017 article

Fast and simple analysis of MiSeq amplicon sequencing data with MetaAmp

Dong, X., Kleiner, M., Sharp, C. E., Thorson, E., Li, C., Liu, D., & Strous, M. (2017, April). (Vol. 4). Vol. 4.

By: X. Dong, M. Kleiner, C. Sharp, E. Thorson, C. Li, D. Liu, M. Strous

Source: ORCID
Added: February 3, 2019

2017 journal article

Genome sequence of the sulfur-oxidizing Bathymodiolus thermophilus gill endosymbiont.

Standards in Genomic Sciences.

Source: ORCID
Added: February 3, 2019

2017 dataset

Metaproteomics of phototrophic biomats from two soda lakes in the Canadian Rocky Mountains

Source: ORCID
Added: February 3, 2019

2017 journal article

Normalization of metatranscriptomic and metaproteomic data for differential gene expression analyses: The importance of accounting for organism abundance

PeerJ Preprints, 5, e2846v1.

By: M. Kleiner

Sources: NC State University Libraries, ORCID
Added: February 7, 2019

2017 dataset

Quantification of mock microbial communities with metagenomes, 16S rRNA gene amplicons and metaproteomics

Source: ORCID
Added: February 3, 2019

2017 dataset

Re-analysis of an ultra-deep and quantitative saliva proteome

Source: ORCID
Added: February 3, 2019

2017 journal article

Short-chain alkanes fuel mussels and sponge Cycloclasticus symbionts from deep-sea gas and oil seeps

Nature Microbiology, 2, 17093.

By: M. Rubin-Blum, C. Antony, C. Borowski, L. Sayavedra, T. Pape, H. Sahling, G. Bohrmann, M. Kleiner ...

Sources: ORCID, NC State University Libraries
Added: February 3, 2019

2016 dataset

Bathymodiolus azoricus host-symbiont proteomics

Source: ORCID
Added: February 3, 2019

2016 journal article

Chemosynthetic sulphur-oxidizing symbionts of marine invertebrate animals are capable of nitrogen fixation

Nature Microbiology, 2, 16195.

By: J. Petersen, A. Kemper, H. Gruber-Vodicka, U. Cardini, M. Geest, M. Kleiner, S. Bulgheresi, M. Mußmann ...

Sources: ORCID, NC State University Libraries
Added: February 3, 2019

2016 journal article

Closely coupled evolutionary history of ecto- and endosymbionts from two distantly-related animal phyla

Molecular Ecology, 25(13), 3203–3223.

By: J. Zimmermann, C. Wentrup, M. Sadowski, A. Blazejak, H. Gruber-Vodicka, M. Kleiner, J. Ott, B. Cronholm ...

Sources: ORCID, NC State University Libraries
Added: February 3, 2019

2016 dataset

Differential proteomics of Lenisia limosa (Breviatea) and its epibiotic Arcobacter symbiont

Source: ORCID
Added: February 3, 2019

2016 journal article

Environmental Breviatea harbor mutualistic Arcobacter epibionts

Nature, 534(7606), 254–258.

By: E. Hamann, H. Gruber-Vodicka, M. Kleiner, H. Tegetmeyer, D. Riedel, S. Littmann, J. Chen, J. Milucka ...

Sources: ORCID, NC State University Libraries
Added: February 3, 2019

2016 journal article

Metabolic and physiological interdependencies in the Bathymodiolus azoricus symbiosis

The ISME Journal, 11(2), 463–477.

By: R. Ponnudurai, M. Kleiner, L. Sayavedra, J. Petersen, M. Moche, A. Otto, D. Becher, T. Takeuchi ...

Source: ORCID
Added: February 3, 2019

2016 journal article

MiL-FISH: Multi-labelled oligonucleotides for fluorescence in situ hybridisation improve visualization of bacterial cells

Applied and Environmental Microbiology, 82(1), 62–70.

By: M. Schimak, M. Kleiner, S. Wetzel, M. Liebeke, N. Dubilier & B. Fuchs

Sources: ORCID, NC State University Libraries
Added: February 3, 2019

2016 dataset

Proteomics of Candidatus Thiodiazotropha endoloripes, the chemosynthetic symbiont of the lucinid clam Loripes lucinalis from the Bay of Fetovaia

Source: ORCID
Added: February 3, 2019

2016 dataset

Proteomics of Cycloclasticus endosymbiont of deep-sea mussel Bathymodiolus heckerae from Campeche Knolls, southern Gulf of Mexico

Source: ORCID
Added: February 3, 2019

2016 journal article

Spontaneous Reversions of an Evolutionary Trait Loss Reveal Regulators of a Small RNA That Controls Multicellular Development in Myxobacteria

Journal of Bacteriology, 198(23), 3142–3151.

By: Y. Yu, M. Kleiner & G. Velicer

Ed(s): C. Mullineaux

Source: ORCID
Added: February 3, 2019

2016 journal article

Transcriptomic and proteomic insights into innate immunity and adaptations to a symbiotic lifestyle in the gutless marine worm Olavius algarvensis

BMC Genomics, 17(1).

By: J. Wippler, M. Kleiner, C. Lott, A. Gruhl, P. Abraham, R. Giannone, J. Young, R. Hettich, N. Dubilier

Source: ORCID
Added: February 3, 2019

2016 dataset

Transcriptomic and proteomic insights into innate immunity and adaptations to a symbiotic lifestyle in the gutless marine worm Olavius algarvensis

Source: ORCID
Added: February 3, 2019

2015 journal article

Abundant toxin-related genes in the genomes of beneficial symbionts from deep-sea hydrothermal vent mussels

ELife, 4, e07966.

By: L. Sayavedra, M. Kleiner, R. Ponnudurai, S. Wetzel, E. Pelletier, V. Barbe, N. Satoh, E. Shoguchi ...

Sources: ORCID, NC State University Libraries
Added: February 3, 2019

2015 journal article

Evaluation of methods to purify virus-like particles for metagenomic sequencing of intestinal viromes

BMC Genomics, 16(7), 7.

By: M. Kleiner, L. Hooper & B. Duerkop

Sources: ORCID, NC State University Libraries
Added: February 3, 2019

2015 journal article

Use of carbon monoxide and hydrogen by a bacteria-animal symbiosis from seagrass sediments

Environmental Microbiology, 17(12), 5023–5035.

By: M. Kleiner, C. Wentrup, T. Holler, G. Lavik, J. Harder, C. Lott, S. Littmann, M. Kuypers, N. Dubilier

Sources: ORCID, NC State University Libraries
Added: February 3, 2019

2014 journal article

Identification and activity of acetate-assimilating bacteria in diffuse fluids venting from deep-sea hydrothermal systems

FEMS Microbiology Ecology, 90(3), 731–746.

By: M. Winkel, P. Pjevac, M. Kleiner, S. Littmann, A. Meyerdierks, R. Amann, M. Mußmann

Sources: ORCID, NC State University Libraries
Added: February 3, 2019

2013 journal article

Metaproteomics Reveals Abundant Transposase Expression in Mutualistic Endosymbionts

Mbio, 4(3).

By: M. Kleiner, J. Young, M. Shah, N. VerBerkmoes & N. Dubilier

Source: ORCID
Added: February 3, 2019

2012 journal article

Convergent and divergent evolution of metabolism in sulfur-oxidizing symbionts and the role of horizontal gene transfer

Current Opinion in Microbiology, 15(5), 621–631.

By: M. Kleiner, J. Petersen & N. Dubilier

Source: ORCID
Added: February 3, 2019

2012 journal article

Convergent and divergent evolution of metabolism in sulfur-oxidizing symbionts and the role of horizontal gene transfer

Current Opinion in Microbiology, 15(5), 621–631.

By: M. Kleiner, J. Petersen & N. Dubilier

Sources: Crossref, ORCID
Added: September 12, 2020

2012 journal article

Metaproteomics of a gutless marine worm and its symbiotic microbial community reveal unusual pathways for carbon and energy use

Proceedings of the National Academy of Sciences of the United States of America, 109(19), E1173–E1182.

By: M. Kleiner, C. Wentrup, C. Lott, H. Teeling, S. Wetzel, J. Young, Y. Chang, M. Shah ...

Source: ORCID
Added: February 3, 2019

2011 journal article

Status quo in physiological proteomics of the uncultured Riftia pachyptila endosymbiont

Proteomics, 11(15), 3106–3117.

By: S. Markert, A. Gardebrecht, H. Felbeck, S. Sievert, J. Klose, D. Becher, D. Albrecht, A. Thurmer ...

Source: ORCID
Added: February 3, 2019

2011 article

The Olavius algarvensis Metagenome Revisited: Lessons Learned from the Analysis of the Low-Diversity Microbial Consortium of a Gutless Marine Worm

Kleiner, M., Woyke, T., Ruehland, C., & Dubilier, N. (2011, November 10). Handbook of Molecular Microbial Ecology II, pp. 319–333.

By: M. Kleiner, T. Woyke, C. Ruehland & N. Dubilier

Source: ORCID
Added: February 3, 2019

Employment

2017 - present

North Carolina State University Raleigh, NC, US
Plant and Microbial Biology