Manasi Krishnakumar

Works (1)

Updated: June 23rd, 2023 22:05

2021 journal article

Fibrin‐specific <scp>poly(N‐isopropylacrylamide)</scp> nanogels for targeted delivery of tissue‐type plasminogen activator to treat thrombotic complications are well tolerated in vivo

Bioengineering & Translational Medicine, 7(2).

By: E. Mihalko n, K. Nellenbach n, M. Krishnakumar n, N. Moiseiwitsch n, J. Sollinger n, B. Cooley *, A. Brown n 

author keywords: disseminated intravascular coagulation; fibrin; nanogels; pNIPAM; targeted delivery; thrombosis; tissue plasminogen activator
TL;DR: The therapeutic efficacy of targeted fibrin‐specific nanogel (FSN) design for targeted delivery of tPA to treat thrombotic complications is demonstrated and key translational parameters for tPA‐FSN therapeutics are evaluated, including optimal tPA •FSN dosage in a DIC rodent model and safety of intravenous tPA•FSN therapies. (via Semantic Scholar)
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Added: December 20, 2021

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