Melanie Lea Hedgespeth

environmental monitoring, environmental chemistry, ecotoxicology, aquatic ecology, pharmaceutical, PPCP, antidepressant, wastewater, behavior, fish, nontarget analysis, suspect screening, PFAS, per- and polyfluoroalkyl substances

Works (10)

Updated: July 5th, 2023 15:34

2021 article

A sprinkling of gold dust: Pine pollen as a carbon source in Baltic Sea coastal food webs

Liénart, C., Cirtwill, A. R., Hedgespeth, M. L., & Bradshaw, C. (2021, November 13). Limnology and Oceanography, Vol. 11.

By: C. Liénart *, A. Cirtwill *, M. Hedgespeth*  & C. Bradshaw *

topics (OpenAlex): Isotope Analysis in Ecology; Geology and Paleoclimatology Research; Marine Biology and Ecology Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: ORCID
Added: December 16, 2021

2021 article

Suspect-screening analysis of a coastal watershed before and after Hurricane Florence using high-resolution mass spectrometry

Hedgespeth, M. L., McCord, J. P., Phillips, K. A., Strynar, M. J., Shea, D., & Nichols, E. G. (2021, March 31). The Science of The Total Environment, Vol. 8.

By: M. Hedgespeth n , J. McCord *, K. Phillips *, M. Strynar *, D. Shea n  & E. Nichols n 

author keywords: HRMS; Wastewater; Water reuse; Forest; Emerging contaminant; Suspect screening
topics (OpenAlex): Tropical and Extratropical Cyclones Research; Coastal wetland ecosystem dynamics; Flood Risk Assessment and Management
TL;DR: The data suggest that the land treatment system is functionally and hydrologically robust to extreme storm events and contributed to dilution of upstream chemical reservoirs for downstream receiving waters for months after the storm. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021

2019 journal article

Expanding phytoremediation to the realms of known and unknown organic chemicals of concern

International Journal of Phytoremediation, 21(14), 1385–1396.

By: M. Hedgespeth n  & E. Nichols n 

author keywords: HRMS; organic contaminant; nontarget; phytoremediation; exposome; pollutome
MeSH headings : Biodegradation, Environmental; Environmental Pollutants; Gas Chromatography-Mass Spectrometry; Mass Spectrometry; Organic Chemicals
topics (OpenAlex): Toxic Organic Pollutants Impact; Metabolomics and Mass Spectrometry Studies; Pharmaceutical and Antibiotic Environmental Impacts
TL;DR: This review provides an overview of targeted, suspect screening, and nontarget HRMS approaches, summarizes the expanding knowledge of regulated and unregulated organic chemicals in the environment, addresses requisite HRMS instrumentation, analysis cost, uncertainty, and data processing techniques, and offers potential bridges of HRMS analyses to phytoremediation research and application. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: ORCID, Crossref, NC State University Libraries
Added: July 3, 2019

2019 journal article

Suspect screening and prioritization of chemicals of concern (COCs) in a forest-water reuse system watershed

Science of The Total Environment, 694, 133378.

By: M. Hedgespeth n , N. Gibson  n, J. McCord *, M. Strynar *, D. Shea n  & E. Nichols n 

author keywords: HRMS; Suspect screening; Wastewater; Forest; Exposome
topics (OpenAlex): Pharmaceutical and Antibiotic Environmental Impacts; Effects and risks of endocrine disrupting chemicals; Health, Environment, Cognitive Aging
TL;DR: Assessing chemical features in ground- and surface waters from a watershed where secondary-treated wastewater is irrigated onto 900 ha of temperate forest offers a more holistic view of chemicals that contribute to the exposome, suggesting that though wastewater may be a source of chemicals to ground and surface Waters on-site, dissipation of wastewater-derived features likely occurs with limited off-site surface water export by the forested land treatment system. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: July 30, 2019

2018 article

Behaviour of freshwater snails (Radix balthica) exposed to the pharmaceutical sertraline under simulated predation risk

Hedgespeth, M. L., Karasek, T., Ahlgren, J., Berglund, O., & Brönmark, C. (2018, January 18). Ecotoxicology.

By: M. Hedgespeth* , T. Karasek *, J. Ahlgren *, O. Berglund * & C. Brönmark *

author keywords: Pharmaceuticals; Behavioural toxicology; Freshwater toxicology; Snail; Predation; Boldness
MeSH headings : Animals; Selective Serotonin Reuptake Inhibitors / toxicity; Sertraline / toxicity; Snails / physiology; Toxicity Tests; Water Pollutants, Chemical / toxicity
topics (OpenAlex): Pharmaceutical and Antibiotic Environmental Impacts; Neuroendocrine regulation and behavior; Cephalopods and Marine Biology
TL;DR: There were no effects of sertraline on NCEs, and there were observed effects of chemical cue from predatory fish on snail behaviour independent of sERTraline exposure, which raises questions on the modes of action of various SSRIs in gastropods, as well as the potential for a trophic “mismatch” of effects between fish predators and snail prey in aquatic systems. (via Semantic Scholar)
Source: ORCID
Added: January 27, 2021

2018 journal article

Comparison of emerging contaminants in receiving waters downstream of a conventional wastewater treatment plant and a forest-water reuse system

Environmental Science and Pollution Research, 25(13), 12451–12463.

By: A. McEachran  n, M. Hedgespeth n , S. Newton *, R. McMahen*, M. Strynar *, D. Shea n , E. Nichols n 

Contributors: A. McEachran  n, M. Hedgespeth n , S. Newton *, R. McMahen*, M. Strynar *, D. Shea n , E. Nichols n 

author keywords: Wastewater; Contaminants of emerging concern (CECs); Forest-water reuse; Nontargeted analysis; Surface water; Water reuse
MeSH headings : Agricultural Irrigation; Environmental Monitoring; Forestry / methods; North Carolina; Waste Disposal, Fluid / methods; Wastewater / analysis; Water Pollutants, Chemical / analysis
topics (OpenAlex): Pharmaceutical and Antibiotic Environmental Impacts; Constructed Wetlands for Wastewater Treatment; Wastewater Treatment and Reuse
TL;DR: Data indicate that FWR systems represent a sustainable wastewater treatment alternative and that emerging contaminant release to waterways was lower at a FWR system than a conventional WWTP. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 article

Assessing Potential Vulnerability and Response of Fish to Simulated Avian Predation after Exposure to Psychotropic Pharmaceuticals

Hedgespeth, M., Nilsson, P., & Berglund, O. (2016, April 13). Toxics.

By: M. Hedgespeth* , P. Nilsson * & O. Berglund *

author keywords: sertraline; fluoxetine; propranolol; SSRI; beta-blocker; fish; bird; behavior; predation
topics (OpenAlex): Animal Behavior and Reproduction; Fish Ecology and Management Studies; Pharmaceutical and Antibiotic Environmental Impacts
TL;DR: None of the substances significantly affected swimming activity of the fish, nor did they increase vulnerability by affecting encounter probability or evasive endpoints compared to control treatments, and counter to expectations, fish exposed to 100 μg/L fluoxetine were less likely to enter the open area of the arena. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: ORCID
Added: June 17, 2019

2013 article

Ecological implications of altered fish foraging after exposure to an antidepressant pharmaceutical

Hedgespeth, M. L., Nilsson, P. A., & Berglund, O. (2013, December 17). Aquatic Toxicology, Vol. 151, pp. 84–87.

By: M. Hedgespeth* , P. Nilsson * & O. Berglund *

Contributors: M. Hedgespeth* , P. Nilsson * & O. Berglund *

author keywords: Pharmaceutical; Sertraline; Fish; Functional response; Foraging ecology
MeSH headings : Animals; Daphnia / physiology; Feeding Behavior / drug effects; Perches / physiology; Sertraline / toxicity; Water Pollutants, Chemical / toxicity
topics (OpenAlex): Pharmaceutical and Antibiotic Environmental Impacts; Environmental Toxicology and Ecotoxicology; Effects and risks of endocrine disrupting chemicals
TL;DR: Feed trials using juvenile Eurasian perch exposed to the selective serotonin reuptake inhibitor (SSRI) sertraline are performed to test the hypothesis that sERTraline alters foraging ecology of the fish in terms of their functional response, and found an exposure-dependent decrease in feeding with increasing sertrals. (via Semantic Scholar)
Source: ORCID
Added: June 17, 2019

2012 article

Pharmaceuticals and personal care products (PPCPs) in treated wastewater discharges into Charleston Harbor, South Carolina

Hedgespeth, M. L., Sapozhnikova, Y., Pennington, P., Clum, A., Fairey, A., & Wirth, E. (2012, August 17). The Science of The Total Environment, Vol. 437, pp. 1–9.

By: M. Hedgespeth* , Y. Sapozhnikova, P. Pennington *, A. Clum, A. Fairey & E. Wirth*

Contributors: M. Hedgespeth* , Y. Sapozhnikova, P. Pennington *, A. Clum, A. Fairey & E. Wirth*

author keywords: Pharmaceutical; Hormone; EPA Method 1694; Influent; Effluent; Estuary
MeSH headings : Nonprescription Drugs / analysis; Pharmaceutical Preparations / analysis; Seasons; Seawater / analysis; South Carolina; Wastewater / analysis; Wastewater / chemistry; Water Pollutants, Chemical / analysis; Water Purification; Water Quality
topics (OpenAlex): Pharmaceutical and Antibiotic Environmental Impacts; Water Treatment and Disinfection; Wastewater Treatment and Reuse
TL;DR: Seasonal and regional trends of pharmaceuticals and personal care products detected in monthly samples from two local wastewater treatment plants in Charleston, South Carolina, USA, over the period of one year indicate reduced degradation in colder months in wastewater and surface water. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: June 17, 2019

2011 article

Analysis of selected natural and synthetic hormones by LC-MS-MS using the US EPA method 1694

Sapozhnikova, Y., Hedgespeth, M., Wirth, E., & Fulton, M. (2011, January 1). Analytical Methods, Vol. 3, pp. 1079–1086.

By: Y. Sapozhnikova *, M. Hedgespeth* , E. Wirth* & M. Fulton*

Contributors: Y. Sapozhnikova *, M. Hedgespeth* , E. Wirth* & M. Fulton*

topics (OpenAlex): Pharmaceutical and Antibiotic Environmental Impacts; Effects and risks of endocrine disrupting chemicals; Pharmacological Effects and Assays
Source: ORCID
Added: June 17, 2019

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