Works (214)

Updated: April 15th, 2024 06:12

2024 journal article

Anti-Glioblastoma Potential and Phenolic Profile of Berry Juices

PROCESSES, 12(2).

By: M. Kopjar*, D. Raucher*, M. Lila n & J. Simunovic n

author keywords: anthocyanins; antiproliferative potential; dwarf elderberry juice; raspberry juice; wild blackberry juice
TL;DR: Wild blackberry juice demonstrated the highest potency, surpassing temozolomide in inhibiting GBM43 cell proliferation, suggesting its superiority over the conventional treatment of glioblastoma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 26, 2024

2024 article

Genotype and ripening method affect carotenoid content and bio-accessibility in banana

Munoz, B., Hayes, M., Perkins-Veazie, P., Gillitt, N., Munoz, M., Kay, C. D., … Iorizzo, M. (2024, March 4). FOOD & FUNCTION, Vol. 3.

By: B. Munoz n, M. Hayes n, P. Perkins-Veazie n, N. Gillitt, M. Munoz, C. Kay n, M. Lila n, M. Ferruzzi n, M. Iorizzo n

Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 8, 2024

2024 journal article

Influence of 2 Weeks of Mango Ingestion on Inflammation Resolution after Vigorous Exercise

NUTRIENTS, 16(1).

author keywords: mangoes; exercise; inflammation; metabolites; gallotannins; oxylipins; tandem mass spectrometry
TL;DR: The 2.25 h cycling bouts induced significant inflammation, but no countermeasure effect was found after 2 weeks of mango ingestion despite the elevation of mango gut-derived phenolic metabolites. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 26, 2024

2024 journal article

Spray dried insect protein-polyphenol particles deliver health-relevant value-added food ingredients

FUTURE FOODS, 9.

By: E. Silva n, J. Xiong n, F. Medeiros n, M. Grace n, M. Moncada n, M. Lila n, R. Hoskin n

author keywords: Alternative protein; Cricket; Food ingredients; Revalorization
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2023 review

Blueberry Supplementation and Skin Health

[Review of ]. ANTIOXIDANTS, 12(6).

By: J. Ivarsson n, A. Pecorelli*, M. Lila n & G. Valacchi n

author keywords: blueberries; skin; inflammation; polyphenol; antioxidant
TL;DR: The argument for blueberries to possibly be an effective agent for skin health is built and the need for further research to elucidate the mechanisms behind the use of both topical application and dietary supplementation with blueberry to bolster cutaneous systems and defensive mechanisms is highlighted. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 14, 2023

2023 journal article

Blueberry intake elevates post-exercise anti-inflammatory oxylipins: a randomized trial

SCIENTIFIC REPORTS, 13(1).

By: D. Nieman*, C. Sakaguchi*, A. Omar*, K. Davis*, C. Shaffner*, R. Strauch n, M. Lila n, Q. Zhang*

Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023

2023 journal article

Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries

ANTIOXIDANTS, 12(5).

author keywords: blueberries; polyphenols; anthocyanins; precision nutrition
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 24, 2023

2023 journal article

Development of Spray Dried Spirulina Protein-Berry Pomace Polyphenol Particles to Attenuate Pollution-Induced Skin Damage: A Convergent Food-Beauty Approach

ANTIOXIDANTS, 12(7).

By: R. Hoskin n, M. Grace n, A. Guiotto n, A. Pecorelli n, G. Valacchi n & M. Lila n

author keywords: sustainability; value-added; repurposing; skin health; cosmeceuticals
TL;DR: It is demonstrated that protein-polyphenol complexation is a synergistic strategy to stabilize and deliver residual fruit/algae phytoactives into cosmeceutical products for skin health applications. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 17, 2023

2023 journal article

Evaluation of saffron extract bioactivities relevant to skin resilience

JOURNAL OF HERBAL MEDICINE, 37.

By: J. Xiong n, M. Grace n, H. Kobayashi* & M. Lila n

author keywords: Tyrosinase; Collagenase; Collagen; Hyaluronic acid; Antioxidant activity; Crocus sativus
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 14, 2023

2023 article

Influence of 2-Weeks Mango Ingestion on Inflammation Resolution After Vigorous Exercise

Sakaguchi, C. A., Nieman, D. C., Omar, A. M., Strauch, R. C., Williams, J. C., & Lila, M. A. (2023, November 29).

By: C. Sakaguchi, D. Nieman, A. Omar, R. Strauch, J. Williams & M. Lila*

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: January 26, 2024

2023 journal article

Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial

AMERICAN JOURNAL OF CLINICAL NUTRITION, 118(2), 382–390.

By: J. Hodges*, M. Maiz*, S. Cao*, P. Lachcik*, M. Peacock*, G. McCabe*, L. McCabe*, D. Cladis* ...

author keywords: bone; blueberries; calcium; osteoporosis; polyphenols; postmenopausal
TL;DR: Moderate consumption of blueberries may be an effective strategy to attenuate bone loss in healthy postmenopausal women and no significant relationships were found between bone resorption biomarkers, 25-hydroxyvitamin D, and interventions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2023 journal article

Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson's Disease

ANTIOXIDANTS, 12(7).

By: M. Tambe*, A. Jacquet*, K. Strathearn*, J. Hensel*, B. Colon*, A. Chandran*, G. Yousef n, M. Grace n ...

author keywords: anthocyanin; Nrf2; paraquat; Parkinson's disease; polyphenols; rotenone
TL;DR: It is suggested that extracts enriched with certain combinations of ANC, PAC, stilbenes, and other polyphenols could potentially slow neurodegeneration in the brains of individuals exposed to PQ or rotenone by activating cellular antioxidant mechanisms and/or alleviating mitochondrial dysfunction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 25, 2023

2023 journal article

Spray drying to produce novel phytochemical-rich ingredients from juice and pomace of American elderberry

FOOD BIOSCIENCE, 55.

author keywords: Sambucus; Dietary supplement; Repurposing; Powder ingredients; Bioaccessibility; Phytochemicals
Sources: Web Of Science, NC State University Libraries
Added: September 18, 2023

2023 article

Spray-drying microencapsulation of blackcurrant and cocoa polyphenols using underexplored plant-based protein sources

Hoskin, R. T., Grace, M. H. H., Xiong, J., & Lila, M. A. (2023, May 9). JOURNAL OF FOOD SCIENCE, Vol. 5.

By: R. Hoskin n, M. Grace n, J. Xiong n & M. Lila n

author keywords: buckwheat; chia; pea; protein; carriers; revalorization
MeSH headings : Polyphenols / chemistry; Plant Proteins / chemistry; Antioxidants / chemistry; Anthocyanins; Chocolate; Pea Proteins; Plant Extracts / chemistry; Cacao / chemistry; Phytochemicals
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 11, 2023

2022 article

Autopolyploid inheritance and a heterozygous reciprocal translocation shape chromosome genetic behavior in tetraploid blueberry (Vaccinium corymbosum)

Mengist, M. F., Bostan, H., De Paola, D., Teresi, S. J., Platts, A. E., Cremona, G., … Iorizzo, M. (2022, September 3). NEW PHYTOLOGIST, Vol. 9.

By: M. Mengist n, H. Bostan n, D. De Paola*, S. Teresi*, A. Platts*, G. Cremona*, X. Qi*, T. Mackey* ...

author keywords: autopolyploid; blueberry (Vaccinium corymbosum L; ); centromeric repeat; chromosomal translocation; chromosome structure; phased genome; polyploid genetic behavior
MeSH headings : Tetraploidy; Blueberry Plants / genetics; Inheritance Patterns; Polyploidy; Chromosomes
TL;DR: A new high‐quality, phased, chromosome‐scale genome of a diploid blueberry, clone W85 is described, which will facilitate new genetic and comparative genomic studies in Vaccinium and the development of genomic assisted selection strategy for this crop. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 4, 2022

2022 article

Bioaccessibility and intestinal cell uptake of carotenoids and chlorophylls differ in powdered spinach by the ingredient form as measured using in vitro gastrointestinal digestion and anaerobic fecal fermentation models

Hayes, M., Mohamedshah, Z., Chadwick-Corbin, S., Hoskin, R., Iorizzo, M., Lila, M. A., … Ferruzzi, M. G. (2022, March 8). FOOD & FUNCTION, Vol. 13.

MeSH headings : Anaerobiosis; Caco-2 Cells; Carotenoids / metabolism; Chlorophyll; Digestion; Fermentation; Health Promotion; Humans; Powders; Spinacia oleracea / metabolism
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 31, 2022

2022 article

Boosting the Bioaccessibility of Dietary Bioactives by Delivery as Protein-Polyphenol Aggregate Particles

Lila, M. A., Hoskin, R. T., Grace, M. H., Xiong, J., Strauch, R., Ferruzzi, M., … Kay, C. (2022, April 8). JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, Vol. 4.

By: M. Lila n, R. Hoskin n, M. Grace n, J. Xiong n, R. Strauch n, M. Ferruzzi*, M. Iorizzo n, C. Kay n

author keywords: bioavailability; digestion; absorption; circulation; uptake; matrix
MeSH headings : Humans; Polyphenols / analysis; Fruit / chemistry; Protein Aggregates; Dietary Proteins; Biological Availability; Food Ingredients
TL;DR: Evidence to date suggests that complexation of phy toactive polyphenolics effectively enhances their health-relevant impacts, specifically because the phytoactives are protected in the protein matrix during transit in the GIT, allowing intact, non-degraded molecules to reach the colon for catabolism at the gut microbiome level. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 14, 2022

2022 journal article

Continuous flow microwave-assisted aqueous extraction of pomace phytoactives for production of protein-polyphenol particles and a protein-enriched ready-to-drink beverage

Future Foods, 5, 100137.

By: R. Hoskin n, N. Plundrich, A. Vargochik & M. Lila n

Source: ORCID
Added: March 4, 2022

2022 article

Continuous flow microwave-assisted aqueous extraction of pomace phytoactives for production of protein-polyphenol particles and a protein-enriched ready-to-drink beverage(vol 5, artn 100137, year 2021)

Hoskin, R. T., Plundrich, N., Vargochik, A., & Lila, M. A. (2022, December). FUTURE FOODS, Vol. 6.

By: R. Hoskin n, N. Plundrich, A. Vargochik & M. Lila n

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 6, 2023

2022 journal article

Dissecting the genetic basis of bioactive metabolites and fruit quality traits in blueberries (Vaccinium corymbosum L.)

FRONTIERS IN PLANT SCIENCE, 13.

By: M. Mengist n, M. Grace n, T. Mackey*, B. Munoz n, B. Pucker*, N. Bassil*, C. Luby*, M. Ferruzzi n, M. Lila n, M. Iorizzo n

author keywords: blueberry; anthocyanin; acylation; glycosylation; QTL mapping; candidate genes; fruit quality; chlorogenic acid
TL;DR: The study provides the first insights into the genetic basis controlling anthocyanins accumulation and composition, chlorogenic acid and fruit quality traits, and establishes a framework to advance genetic studies and molecular breeding for anthcyanins in blueberry. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022

2022 review

Enhancing the Cognitive Effects of Flavonoids With Physical Activity: Is There a Case for the Gut Microbiome?

[Review of ]. FRONTIERS IN NEUROSCIENCE, 16.

By: C. Cheatham*, D. Nieman*, A. Neilson n & M. Lila n

author keywords: age-related; cognition; neuroprotective; phenolic metabolites; prebiotic flavonoids; exercise; microbiome
TL;DR: There is a potential for combined impacts of flavonoids intake and physical exertion on cognitive function, as modulated by the gut microbiome, and that the combination of a flavonoid-rich diet and routine aerobic exercise may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the Gut microbiome. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 28, 2022

2022 journal article

Foaming and sensory characteristics of protein-polyphenol particles in a food matrix

Food Hydrocolloids.

By: J. Diaz n, E. Foegeding n, L. Stapleton, C. Kay n, M. Iorizzo n, M. Ferruzzi n, M. Lila n

author keywords: Particles; Polyphenols; Proteins; Foaming; Sensory; Structure
UN Sustainable Development Goal Categories
Source: ORCID
Added: August 26, 2021

2022 review

Gains and Losses of Agricultural Food Production: Implications for the Twenty-First Century

[Review of ]. ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, 13, 239–261.

By: S. Komarnytsky n, S. Retchin*, C. Vong n & M. Lila n

author keywords: agricultural food systems; genetic improvement; biofortification; phytochemicals; alternative proteins; sustainable agriculture
MeSH headings : Agriculture; Animals; Biodiversity; Climate Change; Crops, Agricultural; Food Supply
TL;DR: This review introduces the concept of agricultural food systems losses and focuses on improved sources of agricultural diversity, proteins with enhanced resilience, and novel monitoring, processing, and distribution technologies that are poised to improve food security, reduce food loss and waste, and improve health profiles in the near future. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science; OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 23, 2022

2022 article

Protein-binding approaches for improving bioaccessibility and bioavailability of anthocyanins

Wu, H., Oliveira, G., & Lila, M. A. (2022, November 18). COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, Vol. 11.

By: H. Wu*, G. Oliveira* & M. Lila n

author keywords: anthocyanin-protein complexes; bioavailability; digestibility; gastrointestinal; pigments
MeSH headings : Animals; Humans; Anthocyanins / chemistry; Biological Availability; Protein Binding; Food
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 19, 2022

2022 article

Six-month intervention with wild blueberries improved speed of processing in mild cognitive decline: a double-blind, placebo-controlled, randomized clinical trial

Cheatham, C. L., Canipelll, L. G., Millsap, G., Stegall, J. M., Chai, S. C., Sheppard, K. W., & Lila, M. A. (2022, September 8). NUTRITIONAL NEUROSCIENCE, Vol. 9.

By: C. Cheatham*, L. Canipelll, G. Millsap*, J. Stegall*, S. Chai*, K. Sheppard*, M. Lila n

author keywords: aging; CANTAB; event-related potentials; flavonoids; mild cognitive decline; speed of processing; polyphenols; wild blueberries
TL;DR: Consumption of wild blueberries for six months improves cognitive aging sequelae by improving the speed of information processing in older adults by restoring speed of processing to the level of the reference group. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 19, 2022

2022 journal article

Spray-dried and freeze-dried protein-spinach particles; effect of drying technique and protein type on the bioaccessibility of carotenoids, chlorophylls, and phenolics

FOOD CHEMISTRY, 388.

By: M. Grace n, R. Hoskin n, M. Hayes n, M. Iorizzo n, C. Kay n, M. Ferruzzi n, M. Lila n

author keywords: Spinach phytochemicals; Whey protein; Soy protein; Drying; In vitro digestion; Dried ingredients
MeSH headings : Carotenoids / metabolism; Chlorophyll / metabolism; Digestion; Excipients / metabolism; Flavonoids / metabolism; Freeze Drying; Phenols / metabolism; Spinacia oleracea / metabolism
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: June 13, 2022

2022 review

The berry health tool chest - an evidence map and interactive resource

[Review of ]. NUTRITION REVIEWS, 80(1), 68–77.

By: K. Kay n, R. Strauch n, C. Granillo n, M. Bame n, J. Xiong n, A. Mast n, B. Burton-Freeman*, C. Kay n, M. Lila n

author keywords: berry; clinical trial design; dietary intervention; evidence mapping; health criteria
MeSH headings : Eating; Fruit; Humans
TL;DR: The development and utility of the "Berry Health Tool Chest," an evidence map summarizing trial design features of studies characterizing the impact of berry consumption upon human health biomarkers, are described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2022

2022 journal article

There and back again; historical perspective and future directions for Vaccinium breeding and research studies

HORTICULTURE RESEARCH, 9.

Sources: Web Of Science, NC State University Libraries
Added: August 1, 2022

2021 journal article

Alaskan Bog Blueberry (Vaccinium uliginosum) Extract as an Innovative Topical Approach to Prevent UV-Induced Skin Damage

COSMETICS, 8(4).

By: E. Pambianchi n, Z. Hagenberg n, A. Pecorelli n, M. Grace n, J. Therrien n, M. Lila n, G. Valacchi n

author keywords: cosmeceuticals; environmental stressor; oxidation; inflammation; antioxidant; OxInflammation; phytochemicals
TL;DR: It is observed that the topical application of BB extract on human ex vivo skin explants averted the UV-induced cutaneous OxInflammatory phenomenon by quenching the increase in the oxidative and inflammatory marker levels. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 2, 2021

2021 article

Building a Resilient, Sustainable, and Healthier Food Supply Through Innovation and Technology

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 12, 2021, Vol. 12, pp. 1–28.

By: D. McClements*, R. Barrangou n, C. Hill*, J. Kokini*, M. Lila n, A. Meyer*, L. Yu*

author keywords: future foods; food production; food processing; environmental impacts; nanotechnology; gene editing; genetic engineering; artificial intelligence; robotics
MeSH headings : Agriculture; Artificial Intelligence; Biotechnology; COVID-19; Food Quality; Food Safety; Food Supply / standards; Humans; Nanotechnology; Pandemics; Robotics
TL;DR: A perspective article, written by members of the Editorial Committee of the Annual Review of Food Science and Technology, highlights some of the major challenges confronting the modern food supply chain as well as how innovations in policy and technology can be used to address them. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 24, 2021

2021 journal article

Cutaneous antimicrobial peptides: New “actors” in pollution related inflammatory conditions

Redox Biology, 41, 101952.

By: B. Woodby, E. Pambianchi, F. Ferrara*, J. Therrien, A. Pecorelli, N. Messano, M. Lila*, G. Valacchi*

author keywords: Skin; LL37; ROS; Antimicrobial peptides; Pollution
MeSH headings : Humans; Hydrogen Peroxide; Keratinocytes; Pore Forming Cytotoxic Proteins; Skin; Skin Diseases
TL;DR: Exposure to O3 is hypothesized to contribute to various cutaneous inflammatory conditions, such as eczema, psoriasis, rush etc via a redox-inflammatory pathway and altered levels of AMPs are observed, suggesting that targeting AMPs could be a possible defensive strategy to combat pollution-associated skin conditions. (via Semantic Scholar)
Source: ORCID
Added: April 1, 2021

2021 journal article

Efficacy of Pecan Husk and Shell Phenolic Extracts Against Phytophthora Blight in Chile Pepper

PLANT HEALTH PROGRESS, 22(3), 342–347.

By: P. Lujan*, S. Dura*, I. Guzman*, M. Grace n, M. Lila n, R. Steiner*, S. Sanogo*

author keywords: Phytophthora capsici; Capsicum annuum; induced resistance; elicitors; proanthocyanidins; soilborne pathogens
TL;DR: Pecan byproducts may be used as additional options for management of Phytophthora blight and the phenolic content in the extracts was largely made up of proanthocyanidins also known as condensed tannins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 18, 2022

2021 journal article

High-density linkage map construction and identification of loci regulating fruit quality traits in blueberry

HORTICULTURE RESEARCH, 8(1).

By: M. Mengist n, H. Bostan n, E. Young n, K. Kay*, N. Gillitt*, J. Ballington n, C. Kay n, M. Ferruzzi n ...

TL;DR: The genetic basis of fruit quality traits in blueberry was dissected and an association between these fruit quality trait and metabolites detected by Proton nuclear magnetic resonance analysis was established. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 1, 2021

2021 article

Influence of simulated food and oral processing on carotenoid and chlorophyll in vitro bioaccessibility among six spinach genotypes

Hayes, M., Corbin, S., Nunn, C., Pottorff, M., Kay, C. D., Lila, M. A., … Ferruzzi, M. G. (2021, May 14). FOOD & FUNCTION, Vol. 5.

By: M. Hayes n, S. Corbin*, C. Nunn*, M. Pottorff*, C. Kay n, M. Lila n, M. Iorrizo n, M. Ferruzzi n

MeSH headings : Biological Availability; Carotenoids / chemistry; Carotenoids / metabolism; Carotenoids / pharmacokinetics; Chlorophyll / chemistry; Chlorophyll / metabolism; Chlorophyll / pharmacokinetics; Digestion; Genotype; Models, Biological; Spinacia oleracea / chemistry; Spinacia oleracea / genetics
TL;DR: It is suggested that the genotype, processing treatment, and genotype × processing (G × P) interaction may affect carotenoid and chlorophyll bioaccessibility in spinach and that food processing remains a dominant factor in modulating the bioavailability of these phytochemicals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 22, 2021

2021 article

Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models

Jacquet, A. de R., Ambaw, A., Tambe, M. A., Ma, S. Y., Timmers, M., Grace, M. H., … Rochet, J.-C. (2021, July 16). FOOD & FUNCTION, Vol. 7.

By: A. Jacquet*, A. Ambaw*, M. Tambe*, S. Ma n, M. Timmers n, M. Grace, Q. Wu*, J. Simon* ...

MeSH headings : Animals; Astrocytes / drug effects; Cells, Cultured; Dietary Supplements; Dopaminergic Neurons / drug effects; Female; Humans; Isoflavones / pharmacology; Male; Models, Biological; Neuroprotective Agents / pharmacology; Parkinson Disease / metabolism; Phytochemicals / pharmacology; Rats; Rats, Sprague-Dawley; Soybeans / chemistry; Trifolium / chemistry
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 10, 2021

2021 journal article

Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage

MOLECULES, 26(13).

By: R. Hoskin n, E. Pambianchi n, A. Pecorelli n, M. Grace n, J. Therrien*, G. Valacchi n, M. Lila n

author keywords: cosmeceuticals; pollution; phytochemicals; herbs
MeSH headings : Antioxidants / chemistry; Antioxidants / pharmacology; Cells, Cultured; Chlorella / chemistry; Cinnamates / chemistry; Depsides / chemistry; Environmental Exposure / adverse effects; Filaggrin Proteins; Humans; Rosmarinus / chemistry; Skin / injuries; Skin / metabolism; Skin / pathology; Skin Aging / drug effects
TL;DR: The ex-vivo data clearly demonstrated the ability of RSP gel to prevent an oxinflammatory phenomenon in cutaneous tissue by decreasing the levels of 4-hydroxynonenal protein adducts and active matrix metalloproteinase-9 (MMP-9) by limiting the loss of filaggrin induced by DEE exposure. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 23, 2021

2021 article

Pea protein isolate characteristics modulate functional properties of pea protein-cranberry polyphenol particles

Strauch, R. C., & Lila, M. A. (2021, May 24). FOOD SCIENCE & NUTRITION, Vol. 5.

By: R. Strauch n & M. Lila n

author keywords: by-products; cranberry polyphenols; digestion; pea protein isolate; solubility
TL;DR: Plant polyphenols have a natural binding affinity for proteins, and their interaction can be exploited to form diverse aggregate particles to allow consumers to incorporate more health‐benefiting plant bioactives into their diets. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 25, 2021

2021 journal article

Phytoecdysteroids Do Not Have Anabolic Effects in Skeletal Muscle in Sedentary Aging Mice

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18(2).

By: M. Lawrence*, K. Zwetsloot*, S. Arthur*, C. Sherman*, J. Huot*, V. Badmaev*, M. Grace n, M. Lila n, D. Nieman*, R. Shanely*

author keywords: skeletal muscle; hypertrophy; Akt; atrogenes; 20-hydroxyecdysone
MeSH headings : Aging; Anabolic Agents; Animals; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Rats
TL;DR: Data indicate that phytoecdysteroid treatment does not alter muscle mass or fiber type, nor does it activate protein synthesis signaling in the skeletal muscle of sedentary aging mice. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 7, 2021

2021 journal article

Skeletal Protection and Promotion of Microbiome Diversity by Dietary Boosting of the Endogenous Antioxidant Response

JOURNAL OF BONE AND MINERAL RESEARCH, 36(4), 768–778.

By: A. Sato*, G. Pellegrini*, M. Cregor*, K. McAndrews*, R. Choi*, M. Maiz*, O. Johnson*, L. McCabe* ...

author keywords: NUTRITION; GENETIC ANIMAL MODELS; SEX STEROIDS; OSTEOPOROSIS; THERAPEUTICS— OTHER
MeSH headings : Animals; Antioxidants; Bone and Bones; Diet; Female; Humans; Male; Mice; Microbiota; Phylogeny
TL;DR: A blueberry cultivar that added to the diet protects female mice from musculoskeletal loss and body weight changes induced by ovariectomy and elicits antioxidant defense responses independently of classical antioxidant/estrogenic signaling, and increases gut microbiome diversity toward a healthier signature. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 19, 2021

2021 journal article

The same anthocyanins served four different ways: Insights into anthocyanin structure-function relationships from the wintergreen orchid, Tipularia discolor

PLANT SCIENCE, 303.

By: N. Hughes*, M. Connors*, M. Grace n, M. Lila n, B. Willans* & A. Wommack*

author keywords: Abaxial/adaxial anthocyanins; Acylated cyanidin; 3,7,3 '-Triglucoside; Camouflage; Chemotaxonomy; Leaf color evolution; Herbivory defense
MeSH headings : Anthocyanins / chemistry; Anthocyanins / isolation & purification; Anthocyanins / physiology; Chromatography, High Pressure Liquid; Color; Gas Chromatography-Mass Spectrometry; Microscopy; Orchidaceae / metabolism; Orchidaceae / ultrastructure; Plant Leaves / metabolism; Plant Leaves / ultrastructure; Structure-Activity Relationship
TL;DR: The results showed that the same three cyanidin 3,7,3'-triglucosides, in similar concentrations and proportions, accounted for coloration in each of these cases, and served as a reminder that plants may employ the same anthocyanins in different anatomical locations to achieve a broad range of colors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 11, 2020

2021 journal article

Whey and soy proteins as wall materials for spray drying rosemary: Effects on polyphenol composition, antioxidant activity, bioaccessibility after in vitro gastrointestinal digestion and stability during storage

LWT-FOOD SCIENCE AND TECHNOLOGY, 149.

By: M. Grace n, R. Hoskin n, J. Xiong n & M. Lila n

author keywords: Protein-polyphenol; Phenolic diterpenes; Bioaccessibility; Rosemary antioxidants; Spray-drying
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 16, 2021

2021 journal article

Whey protein-polyphenol aggregate particles mitigate bar hardening reactions in high protein bars

LWT-FOOD SCIENCE AND TECHNOLOGY, 138.

By: J. Diaz n, E. Foegeding n & M. Lila n

author keywords: Protein bar; Texture; Polyphenol; Particle; Microstructure
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 15, 2021

2020 journal article

Blueberry Extracts as a Novel Approach to Prevent Ozone-Induced Cutaneous Inflammasome Activation

Oxidative Medicine and Cellular Longevity.

By: E. Pambianchi*, F. Ferrara*, A. Pecorelli*, B. Woodby*, M. Grace, J. Therrien, M. Lila*, G. Valacchi*

MeSH headings : Biopsy; Blueberry Plants / chemistry; Cell Death / drug effects; Cell Movement / drug effects; Cell Proliferation / drug effects; HaCaT Cells; Humans; Hydrogen Peroxide / metabolism; Inflammasomes / metabolism; Keratinocytes / drug effects; Keratinocytes / pathology; Models, Biological; Oxidative Stress / drug effects; Ozone / toxicity; Plant Extracts / pharmacology; Protein Multimerization / drug effects; Skin / drug effects; Skin / pathology
TL;DR: The hypothesis that blueberry (BB) extract can effectively reduce skin inflammation and be a possible new technology against cutaneous pollution-induced damage is supported. (via Semantic Scholar)
Source: ORCID
Added: August 15, 2020

2020 journal article

Blueberry and/or Banana Consumption Mitigate Arachidonic, Cytochrome P450 Oxylipin Generation During Recovery From 75-Km Cycling: A Randomized Trial

FRONTIERS IN NUTRITION, 7.

By: D. Nieman*, N. Gillitt*, G. Chen*, Q. Zhang*, W. Sha*, C. Kay n, P. Chandra n, K. Kay*, M. Lila n

author keywords: exercise; lipid mediators; carbohydrate; polyphenols; metabolites; inflammation; fatty acids
TL;DR: Heavy exertion evoked a transient but robust increase in plasma levels of oxylipins in cyclists, with a strong attenuation effect linked to both chronic blueberry and acute banana intake on pro-inflammatory ARA-CYP oxylIPins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 21, 2020

2020 article

Chemical Composition and Bioactive Properties of Commercial and Non-Commercial Purple and White Açaí Berries

Matta, F. V., Xiong, J., Lila, M. A., Ward, N. I., Felipe-Sotelo, M., & Esposito, D. (2020, September 29). (Vol. 9). Vol. 9.

Source: ORCID
Added: October 1, 2020

2020 journal article

Chemical Composition and Bioactive Properties of Commercial and Non-Commercial Purple and White Açaí Berries

Foods, 9(10), 1481.

By: F. Matta*, J. Xiong n, M. Lila n, N. Ward*, M. Felipe-Sotelo* & D. Esposito n

author keywords: acai; total polyphenol; total anthocyanin; antioxidant; elemental analysis; essential elements; biological activity; wound healing
TL;DR: All the açaí samples demonstrated potential as wound healing agents due to the high levels of migration activity in human fibroblast cells, and presented significant levels of calcium, magnesium, manganese, iron, zinc and copper, essential minor and trace elements, in comparison with other berries. (via Semantic Scholar)
Source: ORCID
Added: October 23, 2020

2020 journal article

Development of a genetic framework to improve the efficiency of bioactive delivery from blueberry

SCIENTIFIC REPORTS, 10(1).

By: M. Mengist n, H. Burtch n, H. Debelo n, M. Pottorff n, H. Bostan n, C. Nunn n, S. Corbin n, C. Kay n ...

MeSH headings : Blueberry Plants / genetics; Blueberry Plants / metabolism; Digestion; Flavonoids / metabolism; Genotype; Hydroxybenzoates / metabolism; In Vitro Techniques
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 16, 2020

2020 journal article

Enhanced stability of berry pomace polyphenols delivered in protein-polyphenol aggregate particles to an in vitro gastrointestinal digestion model

Food Chemistry, 331, 127279.

By: J. Xiong n, Y. Chan n, T. Rathinasabapathy n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: J. Xiong n, Y. Chan n, T. Rathinasabapathy n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: Food matrix; By-product; Stability; Antioxidant; Anti-inflammatory
MeSH headings : Animals; Anthocyanins / analysis; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Antioxidants / analysis; Blueberry Plants / chemistry; Digestion; Food-Processing Industry; Fruit / chemistry; Mice; Plant Extracts / chemistry; Plant Extracts / pharmacokinetics; Plant Proteins, Dietary / chemistry; Polyphenols / pharmacokinetics; Proanthocyanidins / analysis; RAW 264.7 Cells; Vitis / chemistry
TL;DR: Protein-polyphenol particle digests retained 1.5 to 2-fold higher antioxidant capacity and suppressed the expression of pro-inflammatory cytokines, iNOS, IL6, and IL1β, compared to unmodified extract digests, which only suppressed IL6. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: June 19, 2020

2020 journal article

Formulation of protein–polyphenol particles for applications in food systems

Food & Function.

By: J. Diaz n, E. Foegeding n & M. Lila n

MeSH headings : Blueberry Plants / chemistry; Chemical Phenomena; Fruit / chemistry; Fruit and Vegetable Juices; Functional Food; Oryza; Particle Size; Plant Proteins, Dietary / chemistry; Polyphenols / chemistry; Vaccinium macrocarpon / chemistry; Whey Proteins / chemistry
TL;DR: Particles formed with whey protein and blueberry juice significantly improved foam stability and drainage half-life and protein-polyphenol particles can be designed as ingredients to stabilize food structures and to increase delivery of health protective polyphenols and proteins in the diet. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: May 30, 2020

2020 journal article

Hypoglycaemic, insulin releasing, and hepatoprotective effect of the aqueous extract of Aloe perryi Baker resin (Socotran Aloe) in streptozotocin-induced diabetic rats

Journal of Taibah University for Science, 14(1), 1671–1685.

author keywords: Aloe perryi; polyphenols; anti-diabetic; anti-hyperlipidemia; ALT; AST
TL;DR: In conclusion, AP extract exerts hypoglycaemic, insulin-releasing, and hepatic antioxidant potentials in diabetic rats. (via Semantic Scholar)
Source: ORCID
Added: December 13, 2020

2020 journal article

In Vitro Bioaccessibility of Carotenoids and Chlorophylls in a Diverse Collection of Spinach Accessions and Commercial Cultivars

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68(11), 3495–3505.

By: M. Hayes n, M. Pottorff n, C. Kay n, A. Van Deynze*, J. Osorio-Marin*, M. Lila n, M. Iorrizo n, M. Ferruzzi n

author keywords: spinach; carotenoids; lutein; beta-carotene; chlorophyll; genotypes; bioaccessibility; in vitro digestion
MeSH headings : Carotenoids; Chlorophyll; Chlorophyll A; Spinacia oleracea / genetics; beta Carotene
TL;DR: The results suggest that carotenoid and chlorophyll bioaccessible contents may vary based on spinach genotypes and may be stable across seasons. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 8, 2020

2020 journal article

LC-MS characterization of bioactive metabolites from two Yemeni Aloe spp. with antioxidant and antidiabetic properties

ARABIAN JOURNAL OF CHEMISTRY, 13(4), 5040–5049.

By: T. Aldayel*, M. Grace n, M. Lila n, M. Yahya*, U. Omar* & G. Alshammary*

Contributors: T. Aldayel*, M. Grace n, M. Lila n, M. Yahya*, U. Omar* & G. Alshammary*

author keywords: LC-ESI-IT-TOF; Aloe; Phenolics; alpha-Glucosidase inhibition; Antioxidant activity
TL;DR: Findings highlight the phytochemical profile, antioxidant and potential antidiabetic activity of the Yemeni Aloe species and draw attention to their potential application in food, medicine and cosmetic products. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 20, 2020

2020 journal article

Phenolic content, anti-inflammatory properties, and dermal wound repair properties of industrially processed and non-processed acai from the Brazilian Amazon

Food & Function, 11(6), 4903–4914.

By: J. Xiong n, F. Matta*, M. Grace n, M. Lila n, N. Ward*, M. Felipe-Sotelo*, D. Esposito n

Contributors: J. Xiong n, F. Matta*, M. Grace n, M. Lila n, N. Ward*, M. Felipe-Sotelo*, D. Esposito n

MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Arecaceae; Brazil; Food Industry; Fruit; Humans; Mice; Phytotherapy; Plant Extracts / chemistry; Plant Extracts / pharmacology; Polyphenols / chemistry; RAW 264.7 Cells / drug effects; Wound Healing / drug effects
TL;DR: The anti-inflammatory effect was diminished but wound healing effect was retained after pulp processing, suggesting the processing technology needs to be improved to maintain biological properties of acai fruit. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: June 5, 2020

2020 journal article

Redox regulation of cutaneous inflammasome by ozone exposure

FREE RADICAL BIOLOGY AND MEDICINE, 152, 561–570.

By: F. Ferrara*, E. Pambianchi*, A. Pecorelli*, B. Woodby*, N. Messano*, J. Therrien, M. Lila*, G. Valacchi*

MeSH headings : Caspase 1 / metabolism; Humans; Hydrogen Peroxide; Inflammasomes / metabolism; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Oxidation-Reduction; Ozone / toxicity; Reactive Oxygen Species
TL;DR: It is demonstrated that O3 can activate cutaneous inflammasome in a redox dependent manner suggesting a possible role of this new pathway in pollution induced inflammatory skin conditions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 13, 2020

2020 article

Skin Health from the Inside Out

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 11, Vol. 11, pp. 235–254.

By: B. Woodby n, K. Penta n, A. Pecorelli n, M. Lila n & G. Valacchi n

author keywords: pollution; skin; diet; GI tract; inflammation; antioxidant; vitamins
MeSH headings : Antioxidants / metabolism; Humans; Reactive Oxygen Species / metabolism; Skin Physiological Phenomena
TL;DR: This review discusses how topical application of antioxidants, including vitamins C and E, carotenoids, resveratrol, and pycnogenol, can be combined with dietary supplementation of these antioxidant compounds in addition to probiotics and essential minerals to protect against outdoor stressor-induced skin damage, including the damage associated with aging. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020

2020 article

The Colors of Health: Chemistry, Bioactivity, and Market Demand for Colorful Foods and Natural Food Sources of Colorants

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 11, Vol. 11, pp. 145–182.

By: E. Mejia*, Q. Zhang*, K. Penta n, A. Eroglu n & M. Lila n

author keywords: anthocyanins; betalains; bioactivity; carotenoids; natural colors; phycocyanins
MeSH headings : Color; Food; Pigments, Biological / chemistry
TL;DR: The color industry needs new sources of stable, functional, and safe natural food colorants, and new opportunities include sourcing new colors from microbial sources and via the use of genetic biotechnology. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020

2019 journal article

Alaskan Berry Extracts Promote Dermal Wound Repair Through Modulation of Bioenergetics and Integrin Signaling

FRONTIERS IN PHARMACOLOGY, 10(SEP).

By: D. Esposito n, J. Overall n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: D. Esposito n, J. Overall n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: skin regeneration; wound healing; Alaskan berries; integrins; proanthocyanidins; epicatechins
TL;DR: Targeting cellular bioenergetics and integrin-mediated cell–ECM signaling with bioactives from Alaskan wild berries shows considerable therapeutic promise to treat chronic skin wounds and inflammatory skin disorders, as well as more generally to support regenerative healing responses and restore function in a variety of tissue and organ settings after injury or aging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 14, 2019

2019 journal article

Anti-inflammatory and wound healing properties of polyphenolic extracts from strawberry and blackberry fruits

FOOD RESEARCH INTERNATIONAL, 121, 453–462.

By: F. Velde*, D. Esposito n, M. Grace n, M. Pirovani* & M. Lila n

Contributors: F. Velde*, D. Esposito n, M. Grace n, M. Pirovani* & M. Lila n

author keywords: Fragaria ananassa; Rubus fruticosus; Anthocyanins; Proanthocyanidins; Cyclooxygenase-2; Interleukin-6; Skin cell migration
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Anti-Inflammatory Agents / analysis; Anti-Inflammatory Agents / pharmacology; Antioxidants / analysis; Antioxidants / pharmacology; Cell Movement / drug effects; Cell Proliferation / drug effects; Cell Survival / drug effects; Chromatography, High Pressure Liquid; Fragaria / chemistry; Fruit / chemistry; Mice; Phytochemicals / analysis; Phytochemicals / pharmacology; Plant Extracts / analysis; Plant Extracts / pharmacology; Polyphenols / analysis; Polyphenols / pharmacology; Proanthocyanidins / analysis; Proanthocyanidins / pharmacology; RAW 264.7 Cells; Reactive Oxygen Species / metabolism; Rubus / chemistry; Wound Healing / drug effects
TL;DR: Results obtained in this work highlight the anti-inflammatory properties of berry polyphenolics, especially due to proanthocyanidins, and promising results were obtained about the effects of bberry anthocyanins on wound healing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2019

2019 journal article

Binding of peanut allergen Ara h 2 with Vaccinium fruit polyphenols

FOOD CHEMISTRY, 284, 287–295.

By: N. Plundrich n, B. Cook n, S. Maleki*, D. Fourches n & M. Lila n

author keywords: Ara h 2; Molecular docking; Polyphenol; IgE binding; Circular dichroism (CD); Food allergy
MeSH headings : 2S Albumins, Plant / chemistry; 2S Albumins, Plant / immunology; 2S Albumins, Plant / metabolism; Antigens, Plant / chemistry; Antigens, Plant / immunology; Antigens, Plant / metabolism; Arachis / metabolism; Biflavonoids / chemistry; Biflavonoids / metabolism; Binding Sites; Catechin / chemistry; Catechin / metabolism; Chlorogenic Acid / chemistry; Chlorogenic Acid / metabolism; Circular Dichroism; Epitopes / chemistry; Epitopes / metabolism; Fruit / chemistry; Fruit / metabolism; Glycoproteins / chemistry; Glycoproteins / immunology; Glycoproteins / metabolism; Humans; Immunoglobulin E / chemistry; Immunoglobulin E / metabolism; Molecular Docking Simulation; Polyphenols / chemistry; Polyphenols / metabolism; Proanthocyanidins / chemistry; Proanthocyanidins / metabolism; Protein Binding; Protein Structure, Secondary; Spectrophotometry; Vaccinium / chemistry; Vaccinium / metabolism
TL;DR: Results suggest that certain polyphenols can inhibit IgE recognition of Ara h 2 by obstructing linear IgE epitopes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 25, 2019

2019 article

Blueberries Topical Application Prevents Ozone Induced Cutaneous Inflammasome Activation

Pambianchi, E., Francesca, F., Pecorelli, A., Woodby, B., Lila, M., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S148–S148.

By: E. Pambianchi, F. Francesca, A. Pecorelli, B. Woodby, M. Lila & G. Valacchi

Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 journal article

Blueberry polyphenol-protein food ingredients: The impact of spray drying on the in vitro antioxidant activity, anti-inflammatory markers, glucose metabolism and fibroblast migration

Food Chemistry, 280, 187–194.

By: R. Hoskin n, J. Xiong n, D. Esposito n & M. Lila n

Contributors: R. Hoskin n, J. Xiong n, D. Esposito n & M. Lila n

author keywords: Berries; By-products; Drying; Inflammation; Phytochemicals
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Blueberry Plants / chemistry; Blueberry Plants / metabolism; Cell Line; Cell Movement / drug effects; Cell Survival / drug effects; Cyclooxygenase 2 / metabolism; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Freeze Drying; Glucose / metabolism; Interleukin-1beta / metabolism; Macrophages / cytology; Macrophages / drug effects; Macrophages / metabolism; Mice; Plant Proteins / chemistry; Plant Proteins / pharmacology; Polyphenols / chemistry; Polyphenols / pharmacology; Protein Aggregates; RAW 264.7 Cells; Rats; Reactive Oxygen Species / metabolism
TL;DR: The data suggests that spray drying is a convenient and cost-effective technique to produce blueberry-polyphenol food ingredients with preserved phytochemicals with biological activities. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: January 28, 2019

2019 journal article

Changes due to high oxygen and high carbon dioxide atmospheres on the general quality and the polyphenolic profile of strawberries

Postharvest Biology and Technology, 148, 49–57.

By: F. Van de Velde*, M. Méndez-Galarraga*, M. Grace n, C. Fenoglio*, M. Lila n & M. Pirovani*

Contributors: F. Velde*, M. Méndez-Galarraga*, M. Grace n, C. Fenoglio*, M. Lila n & M. Pirovani*

author keywords: Modified atmosphere packaging; Abiotic stress; Anthocyanins; Phenolic acids; Ellagitannins; Vitamin C
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019

2019 journal article

Changes in the bioactive properties of strawberries caused by the storage in oxygen- and carbon dioxide-enriched atmospheres

FOOD SCIENCE & NUTRITION, 7(8), 2527–2536.

By: F. Velde*, D. Esposito n, J. Overall n, M. Mendez-Galarraga*, M. Grace n, M. Piroyani, M. Lila n

Contributors: F. Velde*, D. Esposito n, J. Overall n, M. Méndez-Galarraga*, M. Grace n, M. Élida Pirovani*, M. Lila n

author keywords: 2; 2-diphenyl-1-picrylhydrazil; cyclooxygenase-2; ferric reducing antioxidant power; human dermal fibroblast migration; interleukin-6; modified atmosphere storage
TL;DR: Evidence suggests that strawberry storage in 90% O2 + 10% CO2 can be a promissory alternative to offer fruits with enhanced bioactivity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 5, 2019

2019 journal article

Comparison of berry juice concentrates and pomaces and alternative plant proteins to produce spray dried protein–polyphenol food ingredients

Food & Function, 10(10), 6286–6299.

By: R. Hoskin n, J. Xiong n & M. Lila n

Contributors: R. Hoskin n, J. Xiong n & M. Lila n

MeSH headings : Animals; Blueberry Plants / chemistry; Color; Fagopyrum / chemistry; Flour / analysis; Food Handling; Food Ingredients / analysis; Fruit / chemistry; Fruit and Vegetable Juices / analysis; Peas / chemistry; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Proteins / chemistry; Plant Proteins / isolation & purification; Polyphenols / chemistry; Polyphenols / isolation & purification; Vaccinium macrocarpon / chemistry; Vitis / chemistry; Waste Products / analysis
TL;DR: The results suggest an efficient plant-based approach to produce value-added protein-polyphenol aggregates with broad utility as healthy food ingredients as well as good spray drying yield. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: November 4, 2019

2019 article

Immunometabolism: A Multi-Omics Approach to Interpreting the Influence of Exercise and Diet on the Immune System

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 10, Vol. 10, pp. 341–363.

By: D. Nieman*, M. Lila n & N. Gillitt*

author keywords: exercise; diet; immune function; metabolomics; lipidomics; proteomics
MeSH headings : Diet; Exercise; Humans; Immune System; Metabolism
TL;DR: Emerging evidence using large multi-omics data sets supports the combined intake of fruit sugars and phytochemicals by athletes during heavy exertion as an effective strategy to improve metabolic recovery, augment viral defense, and counter postexercise inflammation and immune dysfunction at the cell level. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 22, 2019

2019 journal article

Peanut protein-polyphenol aggregate complexation suppresses allergic sensitization to peanut by reducing peanut-specific IgE in C3H/HeJ mice

FOOD CHEMISTRY, 299.

By: R. Bansode*, P. Randolph*, N. Plundrich n, M. Lila n & L. Williams*

author keywords: Peanut allergy; IgE; CD63; Polyphenol; Blueberry; Cranberry
MeSH headings : Animals; Arachis / chemistry; Arachis / immunology; Female; Immunoglobulin E / immunology; Mice; Mice, Inbred C3H; Peanut Hypersensitivity / prevention & control; Plant Proteins / chemistry; Plant Proteins / immunology; Polyphenols / chemistry; Species Specificity
TL;DR: It is demonstrated for the first time that complexation of polyphenols to peanut flour can potentially lower plasma IgE of peanut-sensitized C3H/HeJ mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019

2019 journal article

Photosynthetic Profiles of Green, Purple, and Spotted-Leaf Morphotypes of Tipularia discolor (Orchidaceae)

SOUTHEASTERN NATURALIST, 18(4), 641–658.

By: N. Hughes*, G. Gigantino*, M. Grace n, K. Hoffman*, M. Lila n, B. Willans*, A. Wommack*

Contributors: N. Hughes*, G. Gigantino*, M. Grace n, K. Hoffman*, M. Lila n, B. Willans*, A. Wommack*

TL;DR: It is concluded that leaf purpling and spotting in Cranefly Orchid are most likely not related to physiological stress, and are more likely genetic in nature, perhaps representing alternative phenotypic adaptations related to herbivory defense. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 6, 2020

2019 journal article

Simultaneous LC-MS quantification of anthocyanins and non-anthocyanin phenolics from blueberries with widely divergent profiles and biological activities

Food Chemistry, 277, 336–346.

By: M. Grace n, J. Xiong n, D. Esposito n, M. Ehlenfeldt* & M. Lila n

Contributors: M. Grace n, J. Xiong n, D. Esposito n, M. Ehlenfeldt* & M. Lila n

author keywords: Pink-fruited; Blueberries; LC-IT-TOF-MS; Quantification; Antioxidant; Anti-inflammatory; PCA
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Anti-Inflammatory Agents / analysis; Anti-Inflammatory Agents / pharmacology; Antioxidants / analysis; Antioxidants / pharmacology; Biological Assay; Blueberry Plants / chemistry; Cell Survival / drug effects; Chromatography, Liquid; Color; Flavonoids / analysis; Flavonoids / pharmacology; Flavonols / analysis; Flavonols / pharmacology; Fruit / chemistry; Hydroxybenzoates / analysis; Hydroxybenzoates / pharmacology; Limit of Detection; Mass Spectrometry; Mice; Nitric Oxide / metabolism; Phenols / analysis; Phenols / pharmacology; Plant Extracts / analysis; Plant Extracts / pharmacology; RAW 264.7 Cells; Reactive Oxygen Species / metabolism; Reproducibility of Results; Resveratrol / analysis; Resveratrol / pharmacology
TL;DR: A sensitive and straightforward LC-IT-TOF-MS method was validated for the profiling and simultaneous quantification of anthocyanins, flavan-3-ols, flavonols, phenolic acids, and resveratrol in blueberry genotypes with fruit color ranging from deep purple to various shades of pink. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 17, 2018

2019 journal article

Variation in anthocyanin profiles of 27 genotypes of red cabbage over two growing seasons

FOOD CHEMISTRY, 301.

By: R. Strauch n, M. Mengist n, K. Pan n, G. Yousef n, M. Iorizzo n, A. Brown n, M. Lila n

author keywords: Red cabbage; Acylated anthocyanin; Breeding population; HPLC-DAD-MSE
MeSH headings : Acylation; Anthocyanins / analysis; Anthocyanins / chemistry; Brassica / chemistry; Brassica / genetics; Brassica / metabolism; Chromatography, High Pressure Liquid; Genotype; Mass Spectrometry; Plant Breeding; Polymorphism, Genetic; Seasons
TL;DR: PCA analysis identified anthocyanin accumulation traits and genotypes with high diversity which can be utilized in future investigations into the genetic and molecular basis for anthochenin production, acylation, and diversity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 23, 2019

2018 article

AtmO(3)spheric skin damage: The oxInflammation phenomena

Valacchi, G., Pecorelli, A., Pambianchi, E., Ferrara, F., & Lila, M. (2018, September). JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 138, pp. B15–B15.

By: G. Valacchi n, A. Pecorelli*, E. Pambianchi*, F. Ferrara n & M. Lila*

Sources: Web Of Science, NC State University Libraries
Added: October 19, 2018

2018 journal article

Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage

FOOD AND CHEMICAL TOXICOLOGY, 111, 445–453.

By: E. Skates n, J. Overall n, K. DeZego n, M. Wilson n, D. Esposito n, M. Lila n, S. Komarnytsky n

author keywords: Bioactive food components; Polyphenols; Obesity; Diabetes; Bioenergetics; Functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Diet; Diet, High-Fat / adverse effects; Energy Metabolism; Fruit / chemistry; Lipid Metabolism; Male; Metabolic Diseases; Methylation; Mice; Mice, Inbred C57BL; Rubus / chemistry
TL;DR: It is shown that consumption of berries containing anthocyanins with enhanced methylation profiles (malvidin and petunidin) is more effective at reducing high fat diet-induced metabolic damage in the C57BL/6 mouse model of polygenic obesity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

In vitro mineral nutrition of Curcuma longa L. affects production of volatile compounds in rhizomes after transfer to the greenhouse

BMC Plant Biology, 18.

By: R. El-Hawaz, M. Grace, A. Janbey, M. Lila & J. Adelberg

Source: NC State University Libraries
Added: August 6, 2018

2018 article

In vitro mineral nutrition of Curcuma longa L. affects production of volatile compounds in rhizomes after transfer to the greenhouse (vol 18, 122, 2018)

BMC Plant Biology, Vol. 18.

By: R. El-Hawaz, M. Grace, A. Janbey, M. Lila & J. Adelberg

Source: NC State University Libraries
Added: August 6, 2018

2018 article

Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following 2-Weeks Flavonoid Supplementation

Nieman, D. C., Kay, C. D., Rathore, A. S., Grace, M. H., Strauch, R. C., Stephan, E. H., … Lila, M. A. (2018, October 15). (Vol. 10). Vol. 10.

By: D. Nieman*, C. Kay n, A. Rathore n, M. Grace n, R. Strauch n, E. Stephan*, C. Sakaguchi*, M. Lila n

Source: ORCID
Added: November 13, 2019

2018 journal article

Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following Two Weeks of Flavonoid Supplementation

Nutrients, 10(11).

By: D. Nieman*, C. Kay n, A. Rathore n, M. Grace n, R. Strauch n, E. Stephan*, C. Sakaguchi*, M. Lila n

Contributors: D. Nieman*, C. Kay n, A. Rathore n, M. Grace n, R. Strauch n, E. Stephan*, C. Sakaguchi*, M. Lila n

author keywords: exercise; polyphenol; metabolite; hippurate; intestinal tract; colon
TL;DR: Data indicate that acute exercise bouts (brisk walking, intensive running) are linked to an increased translocation of gut-derived phenolics into circulation, an effect that is amplified when combined with a two-week period of increased flavonoid intake or chronic training as a runner. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

2018 journal article

Peanut flour aggregation with polyphenolic extracts derived from peanut skin inhibits IgE binding capacity and attenuates RBL-2H3 cells degranulation via MAPK signaling pathway

FOOD CHEMISTRY, 263, 307–314.

By: R. Bansode*, N. Plundrich n, P. Randolph*, M. Lila n & L. Williams*

author keywords: Peanut skin; Peanut flour; Peanut allergy; Degranulation; Polyphenols; RBL-2H3 cells
MeSH headings : Allergens / immunology; Allergens / metabolism; Animals; Arachis / chemistry; Arachis / metabolism; Basophils / cytology; Basophils / drug effects; Basophils / metabolism; Cell Degranulation / drug effects; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Histamine / metabolism; Immunoglobulin E / analysis; Immunoglobulin E / immunology; MAP Kinase Signaling System / drug effects; Plant Proteins / immunology; Plant Proteins / metabolism; Polyphenols / chemistry; Polyphenols / pharmacology; Rats
TL;DR: Results show that aggregation of PSP to PN proteins reduces allergic response by inhibiting Ca2+-induced MAPK-dependent cell degranulation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 article

Protein-polyphenol particles for delivering structural and health functionality (Reprinted from Food Hydrocolloids, vol 72, pg 163-173, 2017)

Foegeding, E. A., Plundrich, N., Schneider, M., Campbell, C., & Lila, M. A. (2018, May). FOOD HYDROCOLLOIDS, Vol. 78, pp. 15–25.

By: E. Foegeding n, N. Plundrich n, M. Schneider n, C. Campbell n & M. Lila n

author keywords: Protein; Polyphenols; Colloidal aggregates; Health, and Structural Functionality
TL;DR: The overall goal should be a rational design of protein-polyphenol particles to ensure a positive contribution to food quality, protein nutrition, and delivery of a health-relevant dose of polyphenols to the gastrointestinal tract. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

SR-B1 involvement in keratinocytes in vitro wound closure

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 658, 1–6.

By: X. Muresan*, C. Sticozzi*, G. Belmonte*, F. Cervellati*, F. Ferrara*, M. Lila n, G. Valacchi n

author keywords: Wound healing; Skin; Proliferation; Migration
MeSH headings : Cell Line, Transformed; Cell Movement / physiology; Cell Proliferation / physiology; Cyclin D1 / metabolism; Gene Knockout Techniques; Humans; Keratinocytes / cytology; Keratinocytes / physiology; Matrix Metalloproteinase 9 / metabolism; NF-kappa B p50 Subunit / metabolism; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / physiology; Skin / metabolism; Wound Healing / physiology
TL;DR: In vitro data demonstrated that SR-B1 influenced keratinocyte proliferation and migration through a downregulation of nuclear cyclin D1 levels and active MMP9 expression respectively possibly in an NF-kB-dependent mechanism, and suggests a new role of SRB1 as a possible new key player in cutaneous wound healing mechanism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 26, 2018

2018 journal article

Tropospheric ozone affects SRB1 levels via oxidative post-translational modifications in lung cells

FREE RADICAL BIOLOGY AND MEDICINE, 126, 287–295.

By: C. Sticozzi*, A. Pecorelli*, A. Romani*, G. Belmonte*, F. Cervellati*, E. Maioli*, M. Lila*, C. Gervellati, G. Valacchi*

MeSH headings : A549 Cells; Aldehydes / metabolism; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Antioxidants / pharmacology; Biological Transport / drug effects; Catalase / genetics; Catalase / metabolism; Cell Survival / drug effects; Humans; Hydrogen Peroxide / metabolism; Lung / drug effects; Lung / metabolism; Lung / pathology; Oxidation-Reduction / drug effects; Oxidative Stress / drug effects; Ozone / pharmacology; Protein Processing, Post-Translational / drug effects; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / metabolism; Vitamin E / metabolism
TL;DR: To characterize the molecular mechanism involved in the redox modulation of SRB1, its cellular levels were assessed in human alveolar epithelial cells after O3 exposure and it was demonstrated that O3 induced the loss ofSRB1 protein levels, a mechanism that could account for SRB 1 protein loss. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018

2017 journal article

Anthocyanins in metabolic health and disease

Nutrigenomics and Proteomics in Health and Disease: towards a Systems-Level Understanding of Gene-Diet Interactions, 2nd Edition, 92–124.

By: J. Overall, M. Lila & S. Komarnytsky

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Development, and genetic and metabolic characterization of new tomato mutants with enhanced and deficient carotenoid content

JOURNAL OF HORTICULTURAL SCIENCE & BIOTECHNOLOGY, 92(5), 475–483.

By: Y. Dan*, G. Yousef n, F. Campbell*, D. Phelps*, C. Burnett*, A. Kekkonen*, A. Shockley*, M. Lila n

author keywords: Carotenoid; lycopene; -carotene; Solanum lycopersicum; mutagenesis
TL;DR: Genetic and metabolic analyses showed that new mutants with enhanced and deficient carotenoid content in a single genetic background of tomato cv. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Effect of 4 weeks of high-intensity interval training on exercise performance and markers of inflammation and oxidative stress

FASEB Journal, 31.

By: K. Zwetsloot, D. Nieman, A. Knab, C. John, D. Lomiwes, R. Hurst, N. Gillitt, M. Lila

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Health modifying regions in the oat (Avena sativa) genome responsible for beneficial effects on immune and gastrointestinal health

FASEB Journal, 31.

By: W. Bussler, K. Dezego, M. Bowen, A. Buige, D. Esposito, M. Lila, S. Komarnytsky

Source: NC State University Libraries
Added: August 6, 2018

2017 article

In vitro Hypoallergenicity of Peanut Protein-Blueberry Polyphenol Aggregate Particles

Plundrich, N., Bansode, R., Williams, L., & Lila, M. A. (2017, February). JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol. 139, pp. AB139–AB139.

By: N. Plundrich n, R. Bansode*, L. Williams* & M. Lila n

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

In vitro hypoallergenic potential of peanut protein-polyphenol aggregate particles

FASEB Journal, 31.

By: N. Plundrich, R. Bansode, L. Williams & M. Lila

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Influence of Ingesting a Flavonoid-Rich Supplement on the Metabolome and Concentration of Urine Phenolics in Overweight/Obese Women

JOURNAL OF PROTEOME RESEARCH, 16(8), 2924–2935.

By: D. Nieman*, S. Ramamoorthy*, C. Kay n, C. Goodman*, C. Capps*, Z. Shue*, N. Heyl*, M. Grace n, M. Lila n

Contributors: D. Nieman*, S. Ramamoorthy*, C. Kay n, C. Goodman*, C. Capps*, Z. Shue*, N. Heyl*, M. Grace n, M. Lila n

author keywords: dietary supplement; metabolomics; polyphenol; obesity
MeSH headings : Adolescent; Adult; Aged; Dietary Supplements; Female; Flavonoids / administration & dosage; Flavonoids / pharmacology; Humans; Intestinal Mucosa / metabolism; Metabolome / drug effects; Metabolomics / methods; Middle Aged; Obesity / metabolism; Obesity / urine; Overweight / metabolism; Overweight / urine; Phenols / urine; Young Adult
TL;DR: It was shown that 12 weeks ingestion of a mixed flavonoid nutrient supplement was associated with a corresponding increase in urine total phenolics and gut-derived phenolic metabolites. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Inter- and intra-seasonal changes in anthocyanin accumulation and global metabolite profiling of six blueberry genotypes

JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 59, 105–110.

By: M. Timmers n, M. Grace n, G. Yousef n & M. Lila n

Contributors: M. Timmers n, M. Grace n, G. Yousef n & M. Lila n

author keywords: Anthocyanin; HPLC; PCA; Blueberry; Metabolite profile; Genotype and seasonal variations; Food analysis; Food composition
TL;DR: Genotypes were easily distinguished from one another across each harvest season, indicating that each genotype had distinctly different metabolite profile, whereas each of the rabbiteye genotypes overlapped on the scores plot, indicating commonalities in metabolite profiles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms

JOURNAL OF ETHNOPHARMACOLOGY, 206, 408–425.

By: A. Jacquet*, M. Timmers n, S. Ma n, A. Thieme*, G. McCabe*, J. Vest*, M. Lila, J. Rochet*

MeSH headings : Humans; Indians, North American; Medicine, Traditional; Parkinson Disease / drug therapy; Parkinson Disease / physiopathology; Plants, Medicinal / chemistry
TL;DR: Analysis of contemporary herbal medicinal practices used by members of the Lumbee tribe to treat PD-related symptoms highlights potential therapeutic benefits of botanical extracts used in traditional Lumbee medicine, and provides insight into mechanisms by which an elderflower extract could suppress neurotoxicity elicited by environmental and genetic PD- related insults. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Metabolic Effects of Berries with Structurally Diverse Anthocyanins

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(2).

By: J. Overall n, S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n, D. Esposito n, M. Lila n, S. Komarnytsky n

Contributors: J. Overall n, S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n, D. Esposito n, M. Lila n, S. Komarnytsky n

author keywords: berry; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Anthocyanins / metabolism; Body Composition; Body Weight; Chromatography, High Pressure Liquid; Dietary Supplements; Feces / chemistry; Fruit / metabolism; Gastrointestinal Microbiome; Glucose / metabolism; Humans; Insulin Resistance; Mice; Molecular Structure; Oxygen Consumption
TL;DR: Examination of effects of six berries with structurally diverse anthocyanin profiles on development of metabolic risk factors in the C57BL/6 mouse model of polygenic obesity showed a prominent discrepancy between biological activities of delphinidin/malvidin-versus cyanidin-type anthocianins that could be explained by differences in their structure and metabolism in the gut. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

One-step isolation of carnosic acid and carnosol from rosemary by centrifugal partition chromatography

JOURNAL OF SEPARATION SCIENCE, 40(5), 1057–1062.

By: M. Grace n, Y. Qiang n, S. Sang* & M. Lila n

Contributors: M. Grace n, Y. Qiang n, S. Sang* & M. Lila n

author keywords: carnosic acid; carnosol; centrifugal partition chromatography; Rosmarinus officinalis
MeSH headings : Abietanes / isolation & purification; Chromatography; Plant Extracts / chemistry; Rosmarinus / chemistry
TL;DR: Carnosic acid and carnosol are the main bioactive components responsible for the significant antioxidant activity of Rosmarinus officinalis and were identified by mass spectrometry, tandem mass spectromaetry, and comparison with authentic standards. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Polyphenol-enriched berry extracts naturally modulate reactive proteins in model foods

Food & Function, 8(12), 4760–4767.

By: M. Lila n, M. Schneider n, A. Devlin n, N. Plundrich n, S. Laster n & E. Foegeding n

MeSH headings : Animals; Dendritic Cells / immunology; Food Hypersensitivity / prevention & control; Fruit / chemistry; Fruit and Vegetable Juices / analysis; Functional Food / analysis; Humans; Macrophages / immunology; Ovalbumin / chemistry; Ovalbumin / immunology; Plant Extracts / chemistry; Polyphenols / chemistry; Swine; Tumor Necrosis Factor-alpha / immunology; Whey Proteins / chemistry; Whey Proteins / immunology
TL;DR: The reactive allergenic epitopes of certain proteins were effectively blunted by binding with polyphenols, attenuating the allergenicity of the food proteins, allowing for the potential creation of hypoallergenic protein-berry polyphenol enriched foods. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 17, 2020

2017 journal article

Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities

Chinese Journal of Natural Medicines, 15(11), 816–824.

By: J. Xiong n, M. Grace n, D. Esposito n, S. Komarnytsky n, F. Wang* & M. Lila n

Contributors: J. Xiong n, M. Grace n, D. Esposito n, S. Komarnytsky n, F. Wang* & M. Lila n

author keywords: Acacia mearnsii; Proanthocyanidins; Anti-inflammatory; alpha-Amylase; alpha-Glucosidase
MeSH headings : Acacia / chemistry; Animals; Anti-Inflammatory Agents / isolation & purification; Anti-Inflammatory Agents / pharmacology; Carbohydrate Metabolism / drug effects; Glycoside Hydrolase Inhibitors / pharmacology; Inflammation / metabolism; Interleukin-1beta / metabolism; Lipopolysaccharides; Macrophages / drug effects; Mice; Nitric Oxide / metabolism; Nitric Oxide Synthase Type II / metabolism; Plant Bark / chemistry; Plant Extracts / chemistry; Plant Extracts / pharmacology; Polyphenols / isolation & purification; Polyphenols / pharmacology; Proanthocyanidins / pharmacology; RAW 264.7 Cells; alpha-Amylases / antagonists & inhibitors; alpha-Glucosidases / metabolism
TL;DR: Polyphenols isolated from Acacia mearnsii bark crude extract and fractions obtained by high-speed counter-current chromatography and evaluated their anti-inflammatory and carbolytic enzymes (α-glucosidase and α-amylase) inhibitory activities showed significant activities against reactive oxygen species, nitric oxide production, and expression of pro-inflammatory genes interleukin-1β. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Protein-bound Vaccinium fruit polyphenols decrease IgE binding to peanut allergens and RBL-2H3 mast cell degranulation in vitro

FOOD & FUNCTION, 8(4), 1611–1621.

By: N. Plundrich n, R. Bansode*, E. Foegeding n, L. Williams* & M. Lila n

MeSH headings : Allergens / immunology; Arachis / immunology; Cell Degranulation / drug effects; Fruit / chemistry; Humans; Immunoglobulin E / immunology; Mast Cells / drug effects; Mast Cells / immunology; Mast Cells / physiology; Peanut Hypersensitivity / drug therapy; Peanut Hypersensitivity / immunology; Plant Extracts / pharmacology; Plant Proteins / immunology; Polyphenols / pharmacology; Vaccinium / chemistry
TL;DR: The modification of peanut proteins with cranberry or blueberry polyphenols led to the formation of peanut protein-polyphenol complexes with significantly reduced allergenic potential. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Protein-bound polyphenols create “ghost” band artifacts during chemiluminescence-based antigen detection

F1000Research, 6, 254.

By: N. Plundrich n, M. Lila n, E. Foegeding n & S. Laster n

TL;DR: This study suggests that caution should be taken when evaluating polyphenol-bound proteins by enhanced chemiluminescence Western blotting using horseradish peroxidase and demonstrates that protein-bound polyphenols can be a source of “ghost” band artifacts on Western blots. (via Semantic Scholar)
Source: ORCID
Added: February 17, 2020

2017 journal article

Protein-bound polyphenols create “ghost” band artifacts during chemiluminescence-based antigen detection [version 1; referees: awaiting peer review]

F1000Research, 6(254), 254.

By: N. Plundrich n, M. Lila n, E. Foegeding n & S. Laster n

Source: ORCID
Added: February 17, 2020

2017 journal article

Protein-polyphenol particles for delivering structural and health functionality

FOOD HYDROCOLLOIDS, 72, 163–173.

By: E. Foegeding n, N. Plundrich n, M. Schneider n, C. Campbell n & M. Lila n

author keywords: Protein; Polyphenols; Colloidal aggregates; Health, and Structural Functionality
TL;DR: The overall goal should be a rational design of protein-polyphenol particles to ensure a positive contribution to food quality, protein nutrition, and delivery of a health-relevant dose of polyphenols to the gastrointestinal tract. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Wild blueberry polyphenol-protein food ingredients produced by three drying methods: Comparative physico-chemical properties, phytochemical content, and stability during storage

FOOD CHEMISTRY, 235, 76–85.

By: R. Correia n, M. Grace n, D. Esposito n & M. Lila n

Contributors: R. Correia n, M. Grace n, D. Esposito n & M. Lila n

author keywords: Soy protein isolate; By-products; Spray drying; Phenolics; Shelf life
MeSH headings : Anthocyanins / analysis; Antioxidants; Blueberry Plants / chemistry; Desiccation / methods; Food Handling / methods; Freeze Drying; Phytochemicals; Polyphenols
TL;DR: Overall, spray drying the blueberry extracts complexed with protein proved to be an environment-friendly strategy to produce stable functional ingredients with multiple applications for the food industry. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

alpha-Amylase and alpha-Glucosidase inhibitory activities of phenolic extracts from Eucalyptus grandis x E-urophylla Bark

Journal of Chemistry.

By: P. Jiang, J. Xiong, F. Wang, M. Grace, M. Lila & R. Xu

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

α-Amylase and α-Glucosidase Inhibitory Activities of Phenolic Extracts from Eucalyptus grandis × E. urophylla Bark

Journal of Chemistry, 2017, 1–7.

By: P. Jiang*, J. Xiong*, F. Wang*, M. Grace n, M. Lila n & R. Xu*

Contributors: P. Jiang*, J. Xiong*, F. Wang*, M. Grace n, M. Lila n & R. Xu*

Sources: ORCID, Crossref, NC State University Libraries
Added: November 12, 2019

2016 journal article

A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice

The Journal of Nutritional Biochemistry, 31, 150–165.

By: B. Collins*, J. Hoffman*, K. Martinez*, M. Grace*, M. Lila*, C. Cockrell*, A. Nadimpalli*, E. Chang* ...

Contributors: B. Collins*, J. Hoffman*, K. Martinez*, M. Grace*, M. Lila*, C. Cockrell*, A. Nadimpalli*, E. Chang* ...

author keywords: Grapes; Obesity; Steatosis; Inflammation; Intestines; Microbiota
MeSH headings : Adiposity / drug effects; Animals; Biomarkers / metabolism; Diet, High-Fat; Gastrointestinal Microbiome / drug effects; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Polyphenols / pharmacology; Vitis / chemistry
TL;DR: Data demonstrate that the polyphenol-rich, EP fraction from table grapes attenuated many of the adverse health consequences associated with consuming an HF diet. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019

2016 journal article

Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts

Food Chemistry, 210, 85–95.

By: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

Contributors: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

author keywords: Anacardic acids; Triterpene acids; Carotenoids; Tocopherols; Polyphenols; Anti-inflammatory
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / isolation & purification; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / isolation & purification; Antioxidants / pharmacology; Cell Line; Dose-Response Relationship, Drug; Macrophages / drug effects; Macrophages / metabolism; Mice; Pistacia; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Extracts / pharmacology; Reactive Oxygen Species / antagonists & inhibitors; Reactive Oxygen Species / metabolism
TL;DR: The P extract significantly decreased the non-mitochondrial oxidative burst associated with inflammatory response in macrophages and significantly inhibited the release of nitric oxide and reactive oxygen species in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Formation of whey protein–polyphenol meso-structures as a natural means of creating functional particles

Food & Function, 7(3), 1306–1318.

By: M. Schneider n, D. Esposito n, M. Lila n & E. Foegeding n

MeSH headings : Fruit / chemistry; Hydrogen-Ion Concentration; Particle Size; Plant Extracts / chemistry; Polyphenols / chemistry; Ribes / chemistry; Vaccinium macrocarpon / chemistry; Vitis / chemistry; Whey Proteins / chemistry
TL;DR: Particles improved foam stability, and the anti-inflammatory properties of entrapped polyphenols were maintained in the particles, suggesting highly functional protein-polyphenol particles can be designed to stabilize food structures and simultaneously deliver polyphenol associated with health benefits. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2016 article

Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015

Blumberg, J. B., Basu, A., Krueger, C. G., Lila, M. A., Neto, C. C., Novotny, J. A., … Toner, C. D. (2016, July). ADVANCES IN NUTRITION, Vol. 7, pp. 759S–770S.

author keywords: cranberry; proanthocyanidins; microbiome; cardiometabolic; antimicrobial
MeSH headings : Animals; Anti-Infective Agents; Biofilms; Diet; Fruit / chemistry; Gastrointestinal Microbiome / physiology; Health Promotion; Heart Diseases / prevention & control; Humans; Inflammation; Lipids / blood; Metabolic Diseases / prevention & control; Oxidative Stress; Phytochemicals / administration & dosage; Phytochemicals / analysis; Plant Extracts / pharmacology; Proanthocyanidins; Risk Factors; Vaccinium macrocarpon / chemistry
TL;DR: A limited but growing body of evidence from randomized clinical trials reveals favorable effects of cranberry consumption on measures of cardiometabolic health, including serum lipid profiles, blood pressure, endothelial function, glucoregulation, and a variety of biomarkers of inflammation and oxidative stress. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Impact of a new postharvest disinfection method based on peracetic acid fogging on the phenolic profile of strawberries

POSTHARVEST BIOLOGY AND TECHNOLOGY, 117, 197–205.

By: F. Velde*, M. Grace n, M. Elida Pirovani* & M. Lila n

Contributors: F. Velde*, M. Grace n, M. Pirovani* & M. Lila n

author keywords: Nebulization; Anthocyanins; Proanthocyanidins; Hydroxycinnamic acid derivatives; Ellagitannins
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

In vitro lipolytic, antioxidant and anti-inflammatory activities of roasted pistachio kernel and skin constituents

Food & Function, 7(10), 4285–4298.

By: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

Contributors: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

MeSH headings : Animals; Antioxidants; Cell Survival / drug effects; Cooking; Macrophages / drug effects; Macrophages / metabolism; Mice; Phytochemicals; Pistacia / chemistry; RAW 264.7 Cells; Reactive Oxygen Species; Respiratory Burst; Seeds / chemistry
TL;DR: The SNP had the strongest effect in decreasing non-mitochondrial oxidative burst associated with inflammatory response in macrophages, and was the most potent to inhibit the expression of COX2. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Phytochemical characterization and anti-inflammatory properties of Acacia mearnsii leaves

Natural Product Communications, 11(5), 649–653.

By: J. Xiong, M. Grace, D. Esposito, F. Wang & M. Lila

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Quantitative comparison of phytochemical profile, antioxidant, and anti-inflammatory properties of blackberry fruits adapted to Argentina

JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 47, 82–91.

By: F. Velde*, M. Grace n, D. Esposito n, M. Elida Pirovani* & M. Lila n

Contributors: F. Velde*, M. Grace n, D. Esposito n, M. Pirovani* & M. Lila n

author keywords: Bubo fruticosus; Polyphenols content; Vitamin C; Cyanidin-3-O-glucoside; Proanthocyanidins; Reactive oxygen species; Cyclooxygenase-2; Interleukin-6; Food analysis; Food composition
TL;DR: The potential of blackberries cultivars ‘Black Satin’ and ‘Jumbo’ to contribute to a healthy diet, based on their higher polyphenol content, providing higher antioxidant and anti-inflammatory properties is suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 review

Unraveling anthocyanin bioavailability for human health

[Review of ]. Annual review of food science and technology, vol 7, 7, 375–393.

By: M. Lila, B. Burton-Freeman, M. Grace & W. Kalt

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Alaskan seaweeds lower inflammation in RAW 264.7 macrophages and decrease lipid accumulation in 3T3-L1 adipocytes

JOURNAL OF FUNCTIONAL FOODS, 15, 396–407.

By: J. Kellogg n, D. Esposito n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: J. Kellogg n, D. Esposito n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: Seaweed; Phlorotannin; Monoglycosyldiacylglycerol; Inflammation; Insulin resistance; Fucus distichus
TL;DR: Overall, the Alaskan seaweed F. distichus inhibited proinflammatory responses and improved lipid metabolism, suggesting the potential for seaweed phytochemicals to attenuate inflammatory diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Black Currant Anthocyanins Attenuate Weight Gain and Improve Glucose Metabolism in Diet-Induced Obese Mice with Intact, but Not Disrupted, Gut Microbiome

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(27), 6172–6180.

By: D. Esposito n, T. Damsud n, M. Wilson n, M. Grace n, R. Strauch n, X. Li n, M. Lila n, S. Komarnytsky n

Contributors: D. Esposito n, T. Damsud n, M. Wilson n, M. Grace n, R. Strauch n, X. Li n, M. Lila n, S. Komarnytsky n

author keywords: gastrointestinal tract; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animals; Anthocyanins / administration & dosage; Anthocyanins / chemistry; Fruit / chemistry; Gastrointestinal Microbiome / drug effects; Glucose / metabolism; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity / drug therapy; Obesity / metabolism; Obesity / microbiology; Obesity / physiopathology; Plant Extracts / administration & dosage; Plant Extracts / chemistry; Ribes / chemistry; Weight Gain / drug effects
TL;DR: The data clearly demonstrate that gut microbiome and the type of the anthocyanin aglycone moiety can alter the protective effect of Anthocyanins against obesity and associated insulin resistance. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Characterization of Phenolic Compounds and Antioxidant and Antiinflammatory Activities from Mamuyo (Styrax ramirezii Greenm.) Fruit

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(48), 10459–10465.

By: M. Timmers n, J. Guerrero-Medina n, D. Esposito n, M. Grace n, O. Paredes-Lopez*, P. Garcia-Saucedo*, M. Ann Lila n

Contributors: M. Timmers n, J. Guerrero-Medina n, D. Esposito n, M. Grace n, O. Paredes-López*, P. García-Saucedo*, M. Lila n

author keywords: LC-TOF-MS; Styrax ramirezii; antioxidant activity; anti-inflammatory activity; norneolignan
MeSH headings : Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / pharmacology; Cyclooxygenase 2 / immunology; Fruit / chemistry; Humans; Interleukin-1beta / immunology; Nitric Oxide / immunology; Nitric Oxide Synthase Type II / immunology; Nitric Oxide Synthase Type II / metabolism; Phenols / chemistry; Phenols / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology; Reactive Oxygen Species / metabolism; Styrax / chemistry
TL;DR: Egonol potently inhibited the production of NO and also significantly reduced the release of ROS, suggesting the potential of S. ramirezii Greenm. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Community-based research as a mechanism to reduce environmental health disparities in American Indian and Alaska native communities

International Journal of Environmental Research and Public Health, 12(4), 4076–4100.

By: C. McOliver, A. Camper, J. Doyle, M. Eggers, T. Ford, M. Lila, J. Berner, L. Campbell, J. Donatuto

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Compounds leached from quinoa seeds inhibit matrix metalloproteinase activity and intracellular reactive oxygen species

INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, 37(2), 212–221.

By: B. Graf*, D. Cheng*, D. Esposito n, T. Shertel*, A. Poulev*, N. Plundrich n, D. Itenberg*, N. Dayan, M. Lila n, I. Raskin*

author keywords: ageing; cell culture; chemical analysis; oxidative damage; phytochemistry; phytoecdysteroid
MeSH headings : Cells, Cultured; Chenopodium quinoa / embryology; Chromatography, Liquid; Humans; Mass Spectrometry; Matrix Metalloproteinase 1 / drug effects; Matrix Metalloproteinase 1 / genetics; Monophenol Monooxygenase / antagonists & inhibitors; Protease Inhibitors / pharmacology; Reactive Oxygen Species / metabolism; Seeds / chemistry
TL;DR: This work aimed to determine the effect of QL and its chemically distinct fractions on five biochemical endpoints relevant to skin care applications: cell viability, matrix metalloproteinase (MMP) mRNA expression, MMP enzymatic activity, tyrosinase enzymatics activity and intracellular reactive oxygen species (ROS) production. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Method to harness bioactive secondary metabolites from intact Quinoa seeds with implications for chronic disease prevention

Planta Medica, 81(11).

By: B. Graf*, A. Poulev*, P. Kuhn*, D. Esposito n, M. Lila n & I. Raskin*

Sources: Crossref, NC State University Libraries
Added: February 21, 2020

2015 journal article

New functionally-enhanced soy proteins as food ingredients with anti-viral activity

VirusDisease, 26(3), 123–132.

By: A. Turmagambetova*, N. Sokolova*, A. Bogoyavlenskiy*, V. Berezin*, M. Lila n, D. Cheng*, V. Dushenkov*

TL;DR: Anti-viral properties of both cranberry juice-en enriched and cranberry pomace polyphenol-enriched soy protein isolate (CB-SPI and CBP- SPI) were tested against influenza viruses in vitro and in ovo and suggest CB-SPi and CBPs may have preventative and therapeutic potential against viral infections that cause diseases of the respiratory and gastro-intestinal tract. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020

2015 journal article

Novel strategies for capturing health-protective mango phytochemicals in shelf stable food matrices

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 66(2), 175–185.

By: I. Guzman n, M. Grace n, G. Yousef n, I. Raskin* & M. Lila n

Contributors: I. Guzman n, M. Grace n, G. Yousef n, I. Raskin* & M. Lila n

author keywords: Carotenoids; fortified foods; polyphenols; protein-rich flour; vitamin A
MeSH headings : Africa; Arachis; Carbohydrates / analysis; Carotenoids / administration & dosage; Carotenoids / analysis; Diet; Dietary Proteins; Flour / analysis; Food Handling / methods; Food Preservation; Fruit / chemistry; Health; Helianthus; Humans; Malnutrition / prevention & control; Mangifera / chemistry; Phytochemicals / analysis; Plant Oils; Polyphenols / administration & dosage; Polyphenols / analysis; Rural Population; Soybeans; Sunflower Oil
TL;DR: Cost-effective methods for concentration and stabilization of otherwise perishable mango fruit phytoactives into shelf stable high protein ingredients were developed to combat stunting (malnutrition) in rural Africa and capture the benefits of Otherwise perishable seasonal resources by complexing healthful proteins together with phy toactive compounds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Novel value-added uses for sweet potato juice and flour in polyphenol- and protein-enriched functional food ingredients

FOOD SCIENCE & NUTRITION, 3(5), 415–424.

By: M. Grace n, A. Truong n, V. Truong, I. Raskin* & M. Lila n

Contributors: M. Grace n, A. Truong n, V. Truong, I. Raskin* & M. Lila n

author keywords: Anti-inflammatory; antioxidant; berries; polyphenols; stability; sweet potato
TL;DR: Sensory evaluation of the ingredient matrices suggested potential uses for a wide range of functional food products, and anti-inflammatory and antioxidant fruit polyphenols with sweet potato functional constituents correlated well with total phenolic content. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

RNA-Seq analysis and annotation of a draft blueberry genome assembly identifies candidate genes involved in fruit ripening, biosynthesis of bioactive compounds, and stage-specific alternative splicing

Gigascience, 4.

By: V. Gupta, A. Estrada, I. Blakley, R. Reid, K. Patel, M. Meyer, S. Andersen, A. Brown, M. Lila, A. Loraine

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Stability and immunogenicity of hypoallergenic peanut protein-polyphenol complexes during in vitro pepsin digestion

FOOD & FUNCTION, 6(7), 2145–2154.

By: N. Plundrich n, B. White, L. Dean, J. Davis, E. Foegeding n & M. Lila n

MeSH headings : Antigens, Plant / chemistry; Antigens, Plant / immunology; Arachis / chemistry; Arachis / immunology; Digestion; Pepsin A / chemistry; Plant Proteins / chemistry; Plant Proteins / immunology; Polyphenols / chemistry; Polyphenols / immunology
TL;DR: It is suggested that peanut protein-polyphenol complexes may be less immunoreactive passing through the digestive tract in vivo, contributing to their attenuated allergenicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

A need for a transdisciplinary environment: the Plant Pathways Elucidation Project

Reid, R. W., Brouwer, C. R., Jackson, E. W., & Lila, M. A. (2014, August). TRENDS IN PLANT SCIENCE, Vol. 19, pp. 485–487.

By: R. Reid, C. Brouwer, E. Jackson* & M. Lila n

MeSH headings : Humans; Industry; Interdisciplinary Communication; Knowledge Bases; Metabolic Networks and Pathways; Plants / metabolism; Universities
TL;DR: The Plant Pathways Elucidation Project (P2EP) is a multi-institutional project that utilizes cutting-edge genomics research and related disciplines to provide greater understanding of the relation between plant-pathway products and human health. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Ajuga turkestanica increases Notch and Wnt signaling in aged skeletal muscle

European Review for Medical and Pharmacological Sciences, 18(17), 2584–2592.

By: S. Arthur, K. Zwetsloot, M. Lawrence, D. Nieman, M. Lila, M. Grace, R. Howden, I. Cooley ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Anthocyanin profiling of wild maqui berries (Aristotelia chilensis [Mol.] Stuntz) from different geographical regions in Chile

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 94(13), 2639–2648.

By: C. Fredes*, G. Yousef n, P. Robert*, M. Grace n, M. Lila n, M. Gomez*, M. Gebauer*, G. Montenegro*

Contributors: C. Fredes*, G. Yousef n, P. Robert*, M. Grace n, M. Lila n, M. Gómez*, M. Gebauer*, G. Montenegro*

author keywords: delphinidin-3; 5-diglucoside; delphinidin-3-glucoside; genetic diversity; maqui genotypes; ISSR-PCR
MeSH headings : Altitude; Anthocyanins / analysis; Anthocyanins / metabolism; Antioxidants / analysis; Antioxidants / metabolism; Chile; Chromatography, High Pressure Liquid; Climate; Elaeocarpaceae / chemistry; Elaeocarpaceae / genetics; Elaeocarpaceae / growth & development; Elaeocarpaceae / metabolism; Fruit / chemistry; Fruit / genetics; Fruit / growth & development; Fruit / metabolism; Genetic Markers; Genetic Variation; Limit of Detection; Phenols / analysis; Phenols / metabolism; Phylogeny; Spatio-Temporal Analysis; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Wilderness
TL;DR: Three maqui genotypes exhibited significantly higher anthocyanin content than the others, as measured by pH differential method and high-performance liquid chromatography-mass spectrometry and significant genetic diversity was noted within each ecological population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Bioactive Capacity, Sensory Properties, and Nutritional Analysis of a Shelf Stable Protein-rich Functional Ingredient with Concentrated Fruit and Vegetable Phytoactives

PLANT FOODS FOR HUMAN NUTRITION, 69(4), 372–378.

By: M. Grace n, G. Yousef n, D. Esposito n, I. Raskin* & M. Lila n

Contributors: M. Grace n, G. Yousef n, D. Esposito n, I. Raskin* & M. Lila n

author keywords: Muscadine; Kale; Protein isolate; Inflammatory biomarkers
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Anti-Inflammatory Agents / therapeutic use; Brassica / chemistry; Cannabis; Carotenoids / pharmacology; Carotenoids / therapeutic use; Chemokine CCL2 / metabolism; Diet; Dietary Proteins / analysis; Fruit / chemistry; Functional Food / analysis; Glucosinolates / pharmacokinetics; Glucosinolates / pharmacology; Humans; Inflammation / drug therapy; Inflammation / metabolism; Interleukin-6 / metabolism; Mice; Nutritive Value; Plant Preparations / pharmacology; Plant Preparations / therapeutic use; Polyphenols / pharmacology; Polyphenols / therapeutic use; Soybean Proteins; Taste; Vegetables / chemistry; Vitis / chemistry
TL;DR: Proximate analyses determined that fortification of the soy protein isolate with muscadine or kale bioactives resulted in elevated dietary fibers, total carbohydrates, and free sugars, but did not increase calories/100 g dry matrix compared to unfortified SPI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 conference paper

Capitalizing on the health benefits of berryfruit: Science versus the marketplace

Ii international symposium on biotechnology of fruit species, 1048, 123–128.

By: M. Lila n

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2014 journal article

Comparative Analysis of Phenolic Content and Profile, Antioxidant Capacity, and Anti-inflammatory Bioactivity in Wild Alaskan and Commercial Vaccinium Berries

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(18), 4007–4017.

By: M. Grace n, D. Esposito n, K. Dunlap* & M. Lila n

Contributors: M. Grace n, D. Esposito n, K. Dunlap* & M. Lila n

author keywords: Vaccinium vitis-idaea; V. uliginosum; V. macrocarpon; V. angustifolium; phenolics; antioxidant; anti-inflammatory
MeSH headings : Alaska; Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / pharmacology; Chromatography, High Pressure Liquid; Fruit / chemistry; Macrophages / drug effects; Macrophages / immunology; Mass Spectrometry; Mice; Phenols / chemistry; Plant Extracts / chemistry; Plant Extracts / pharmacology; Vaccinium / chemistry
TL;DR: A polyphenol-rich fraction from lowbush cranberry exhibited dose-dependent inhibition of LPS-elicited induction of IL-1β in RAW 2647 cells, indicative of strong anti-inflammatory activity, corroborate the historic use of wild Alaskan berries as medicinally important foods in Alaska Native communities. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Concentrating Immunoprotective Phytoactive Compounds from Fruits and Vegetables into Shelf-stable Protein-rich Ingredients

PLANT FOODS FOR HUMAN NUTRITION, 69(4), 317–324.

By: G. Yousef n, M. Grace n, J. Medina n, S. Neff n, I. Guzman n, A. Brown n, I. Raskin*, M. Lila n

Contributors: G. Yousef n, M. Grace n, J. Medina n, S. Neff n, I. Guzman n, A. Brown n, I. Raskin*, M. Lila n

author keywords: Muscadine; Kale; Polyphenolics; Carotenoids; Glucosinolates; Protein isolate
MeSH headings : Brassica / chemistry; Carotenoids / analysis; Diet; Dietary Proteins; Food Handling; Fruit / chemistry; Functional Food; Glucosinolates / analysis; Humans; Immunologic Factors; Plant Extracts / chemistry; Polyphenols / analysis; Vegetables / chemistry; Vitis / chemistry
TL;DR: Neither total phenolics nor glucosinolates were significantly diminished even after long term storage at 4, 20, or 37 °C, whereas carotenoids degraded over time, particularly at higher temperatures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Cytotoxic Effects of Ellagitannins Isolated from Walnuts in Human Cancer Cells

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 66(8), 1304–1314.

By: V. Le*, D. Esposito n, M. Grace n, D. Ha*, A. Pham*, A. Bortolazzo*, Z. Bevens*, J. Kim* ...

Contributors: V. Le*, D. Esposito n, M. Grace n, D. Ha*, A. Pham*, A. Bortolazzo*, Z. Bevens*, J. Kim* ...

MeSH headings : 3T3 Cells; Animals; Apoptosis / drug effects; Cell Line, Tumor; Cyclin B1 / metabolism; Cytochromes c / metabolism; Diet; HeLa Cells; Humans; Hydrogen-Ion Concentration; Hydrolyzable Tannins / pharmacology; Juglans / chemistry; MCF-7 Cells; Mice; Mice, Nude; Mitochondria / drug effects; Nuts / chemistry; Plant Extracts / pharmacology
TL;DR: The results suggest impairment of mitochondrial function and apoptosis as relevant mechanism of anticancer effects of the walnut extract as well as antimitogenic effects of walnuts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1)

FOOD CHEMISTRY, 142, 349–357.

By: D. Ribnicky*, D. Roopchand*, A. Oren*, M. Grace n, A. Poulev*, M. Lila n, R. Havenaar, I. Raskin*

Contributors: D. Ribnicky*, D. Roopchand*, A. Oren*, M. Grace n, A. Poulev*, M. Lila n, R. Havenaar, I. Raskin*

author keywords: Blueberry; Anthocyanins; Bioavailability; Bioaccessibility; Gastrointestinal model; TIM-1; Soybean flour; Nutrition
MeSH headings : Anthocyanins / metabolism; Anthocyanins / pharmacokinetics; Biological Availability; Blueberry Plants / metabolism; Cell Line; Dietary Fats / analysis; Dietary Fats / metabolism; Digestion; Fruit / metabolism; Gastrointestinal Tract / metabolism; Humans; Intestinal Absorption; Models, Biological; Soybean Proteins / chemistry; Soybean Proteins / metabolism
TL;DR: The TNO intestinal model (TIM-1) of the human upper gastrointestinal tract was used to compare intestinal absorption/bioaccessibility of blueberry anthocyanins under different digestive conditions, suggesting lipid-rich matrices selectively effect Anthocyanin bioaccessibility. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Efficient preparative isolation and identification of walnut bioactive components using high-speed counter-current chromatography and LC-ESI-IT-TOF-MS

FOOD CHEMISTRY, 158, 229–238.

By: M. Grace n, C. Warlick n, S. Neff n & M. Lila n

Contributors: M. Grace n, C. Warlick n, S. Neff n & M. Lila n

author keywords: Walnut; Jug Ions regia; Ellagitannins; High-speed counter-current; chromatography; ESI-MS/MS
MeSH headings : Chromatography, High Pressure Liquid / methods; Countercurrent Distribution / methods; Juglans / chemistry; Tandem Mass Spectrometry / methods
TL;DR: These results provided a foundation for in depth characterisation of walnut compounds and offered an efficient strategy for isolation of potentially health-relevant phytochemicals from walnuts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Inhibitory Effects of Wild Blueberry Anthocyanins and Other Flavonoids on Biomarkers of Acute and Chronic Inflammation in Vitro

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(29), 7022–7028.

By: D. Esposito n, A. Chen n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: D. Esposito n, A. Chen n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: Vaccinium angustifolium; lowbush blueberry; polyphenols; proanthocyanidins; chlorogenic acid
MeSH headings : Acute Disease; Animals; Anthocyanins / pharmacology; Base Sequence; Biomarkers / metabolism; Blueberry Plants / chemistry; Cell Line; Chromatography, High Pressure Liquid; Chronic Disease; DNA Primers; In Vitro Techniques; Inflammation / metabolism; Macrophages / drug effects; Macrophages / metabolism; Mice; Polymerase Chain Reaction
TL;DR: Among major polyphenols found in the wild blueberries, malvidin-3-glucoside was significantly more effective than epicatechin or chlorogenic acid in reducing the expression of pro-inflammatory genes in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Leishmanicidal activity of a daucane sesquiterpene isolated from Eryngium foetidum

PHARMACEUTICAL BIOLOGY, 52(3), 398–401.

By: P. Rojas-Silva*, R. Graziose*, B. Vesely*, A. Poulev*, F. Mbeunkui n, M. Grace n, D. Kyle*, M. Lila n, I. Raskin*

Contributors: P. Rojas-Silva*, R. Graziose*, B. Vesely*, A. Poulev*, F. Mbeunkui n, M. Grace n, D. Kyle*, M. Lila n, I. Raskin*

author keywords: Apiaceae; bioassay guided fractionation; cytotoxicity; leishmaniasis; LC-MS; NMR; sesquiterpenoids
MeSH headings : Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / isolation & purification; Antiprotozoal Agents / pharmacology; Cell Line; Chromatography / methods; Chromatography, High Pressure Liquid / methods; Eryngium / chemistry; Inhibitory Concentration 50; Leishmania / drug effects; Leishmania donovani / drug effects; Magnetic Resonance Spectroscopy / methods; Mass Spectrometry / methods; Myoblasts / drug effects; Myoblasts / metabolism; Myoblasts, Skeletal / drug effects; Myoblasts, Skeletal / metabolism; Plant Components, Aerial; Rats; Sesquiterpenes / administration & dosage; Sesquiterpenes / isolation & purification; Sesquiterpenes / pharmacology; Toxicity Tests
TL;DR: The bioassay-guided fractionation with the leishmanicidal and cytotoxicity activities of two compounds isolated for the first time from an Eryngium species were presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease

Brain Research, 1555, 60–77.

By: K. Strathearn*, G. Yousef n, M. Grace n, S. Roy*, M. Tambe*, M. Ferruzzi*, Q. Wu*, J. Simon* ...

Contributors: K. Strathearn*, G. Yousef n, M. Grace n, S. Roy*, M. Tambe*, M. Ferruzzi*, Q. Wu*, J. Simon*, M. Lila n, J. Rochet*

author keywords: Anthocyanin; Microglial activation; Mitochondria; Parkinson's disease; Proanthocyanidin; Rotenone
MeSH headings : Animals; Anthocyanins / therapeutic use; Cells, Cultured; Dopaminergic Neurons / drug effects; Dopaminergic Neurons / metabolism; Mice; Microglia / drug effects; Mitochondria / drug effects; Mitochondria / metabolism; Neuroprotective Agents / therapeutic use; Parkinson Disease / drug therapy; Parkinson Disease / metabolism; Phytotherapy; Plant Extracts / therapeutic use; Proanthocyanidins / therapeutic use; Rotenone / toxicity; Tyrosine 3-Monooxygenase / metabolism
TL;DR: It is suggested that anthocyanin- and proanthocyanidin-rich botanical extracts may alleviate neurodegeneration in PD via enhancement of mitochondrial function. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2014 journal article

Novel Strategy To Create Hypoallergenic Peanut Protein-Polyphenol Edible Matrices for Oral Immunotherapy

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(29), 7010–7021.

By: N. Plundrich n, M. Kulis*, B. White, M. Grace n, R. Guo*, A. Burks*, J. Davis, M. Lila n

Contributors: N. Plundrich n, M. Kulis*, B. White, M. Grace n, R. Guo*, A. Burks*, J. Davis, M. Lila n

author keywords: basophil; cranberry; mouse model; peanut allergy; polyphenols
MeSH headings : Administration, Oral; Arachis / immunology; Arachis / metabolism; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Humans; Immunotherapy; Peanut Hypersensitivity / prevention & control; Plant Proteins / administration & dosage; Plant Proteins / immunology; Polyphenols / administration & dosage; Polyphenols / immunology; Spectroscopy, Fourier Transform Infrared
TL;DR: Polyphenol fortification of peanut flour resulted in a hypoallergenic matrix with reduced IgE binding and degranulation capacity, likely due to changes in protein secondary structure or masking of epitopes, suggesting potential applications for oral immunotherapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Phlorotannins from Alaskan Seaweed Inhibit Carbolytic Enzyme Activity

MARINE DRUGS, 12(10), 5277–5294.

By: J. Kellogg n, M. Grace n & M. Lila n

Contributors: J. Kellogg n, M. Grace n & M. Lila n

author keywords: Alaska; seaweed; diabetes; glucosidase; hyperglycemia; amylase; type 2 diabetes mellitus; phlorotannin; polyphenol; ethnopharmacology
MeSH headings : Animals; Biological Factors / metabolism; Biological Factors / pharmacology; Carbohydrates; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Fucus / metabolism; Kinetics; Saccharomyces cerevisiae / metabolism; Seaweed / metabolism; Swine / metabolism; Tannins / metabolism; Tannins / pharmacology; alpha-Amylases / antagonists & inhibitors; alpha-Glucosidases / metabolism
TL;DR: It is suggested that coastal Alaskan seaweeds are sources of α-glucosidase and α-amylase inhibitory phlorotannins, and thus have potential to limit the release of sugar from carbohydrates and thus alleviate postprandial hyperglycemia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Phytochemical changes in phenolics, anthocyanins, ascorbic acid, and carotenoids associated with sweetpotato storage and impacts on bioactive properties

FOOD CHEMISTRY, 145, 717–724.

By: M. Grace n, G. Yousef n, S. Gustafson n, V. Truong, G. Yencho n & M. Lila n

Contributors: M. Grace n, G. Yousef n, S. Gustafson n, V. Truong, G. Yencho n & M. Lila n

author keywords: Sweetpotato; Phenolics; Carotenoids; Antioxidant activity; Storage; Postharvest
MeSH headings : Anthocyanins / analysis; Anthocyanins / isolation & purification; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / isolation & purification; Antioxidants / chemistry; Antioxidants / isolation & purification; Ascorbic Acid / analysis; Ascorbic Acid / isolation & purification; Carotenoids / analysis; Carotenoids / isolation & purification; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Food Storage; Genotype; Humans; Ipomoea batatas / chemistry; Ipomoea batatas / genetics; Ipomoea batatas / metabolism; Lipopolysaccharides; Phenols / analysis; Phenols / isolation & purification; Plant Extracts / chemistry; Reactive Oxygen Species / metabolism; Temperature; Time Factors
TL;DR: Gradual changes in sweetpotato phytochemical content and antioxidant and anti-inflammatory capacity were noted during normal long-term storage, but the specific effects were genotype-dependent. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Quinoa seeds leach phytoecdysteroids and other compounds with anti-diabetic properties

FOOD CHEMISTRY, 163, 178–185.

By: B. Graf*, A. Poulev*, P. Kuhn*, M. Grace n, M. Lila n & I. Raskin*

Contributors: B. Graf*, A. Poulev*, P. Kuhn*, M. Grace n, M. Lila n & I. Raskin*

author keywords: Ecdysterone; Flavonoids; Metabolic syndrome; Nutraceutical; Phytoecdysteroids
MeSH headings : Animals; Chenopodium quinoa / chemistry; Chromatography, Liquid; Ecdysterone / isolation & purification; Ecdysterone / pharmacology; Hypoglycemic Agents / isolation & purification; Male; Mice; Mice, Inbred C57BL; Seeds / chemistry
TL;DR: Leaching effectively releases and concentrates bioactive phytochemicals from quinoa seeds, providing an efficient means to produce a food-grade mixture that may be useful for anti-diabetic applications. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro

PHYTOCHEMISTRY, 103, 114–122.

By: C. Waterman*, D. Cheng*, P. Rojas-Silva*, A. Poulev*, J. Dreifus*, M. Lila n, I. Raskin*

author keywords: Moringa oleifera; Moringaceae Chronic inflammation; Isothiocyanates; 4-[(alpha-L-rhamnosyloxy) benzyl]isothiocyanate; 4-[(4'-O-acetyl-alpha-L-rhamnosyloxy) benzyl]isothiocyanate
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Cell Line; Interleukin-1beta / metabolism; Isothiocyanates / chemistry; Isothiocyanates / pharmacology; Macrophages / drug effects; Macrophages / metabolism; Mice; Moringa oleifera; Nitric Oxide / metabolism; Nitric Oxide Synthase Type II / metabolism; Plant Extracts / chemistry; Plant Extracts / pharmacology; Plant Leaves / chemistry; Water / chemistry
TL;DR: A potential for stable and concentrated moringa isothiocyanates, delivered in MC as a food-grade product, to alleviate low-grade inflammation associated with chronic diseases is suggested. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Stressed for Success: How the Berry's Wild Origins Result in Multifaceted Health Protections

X INTERNATIONAL SYMPOSIUM ON VACCINIUM AND OTHER SUPERFRUITS, Vol. 1017, pp. 23–43.

By: M. Lila*, J. Kellogg*, M. Grace*, G. Yousef*, T. Kraft & R. Rogers

author keywords: elicitation; anthocyanins; proanthocyanidins; inflammation; metabolic syndrome