Works (220)
Updated: November 7th, 2024 05:01
2024 journal article
Anti-Glioblastoma Potential and Phenolic Profile of Berry Juices
PROCESSES, 12(2).
author keywords: anthocyanins; antiproliferative potential; dwarf elderberry juice; raspberry juice; wild blackberry juice
TL;DR:
Wild blackberry juice demonstrated the highest potency, surpassing temozolomide in inhibiting GBM43 cell proliferation, suggesting its superiority over the conventional treatment of glioblastoma.
(via Semantic Scholar)
open access via www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 26, 2024
2024 journal article
Assessing predictability of post-storage texture and appearance characteristics in blueberry at breeding population level
POSTHARVEST BIOLOGY AND TECHNOLOGY, 214.
author keywords: Blueberry; Fruit characteristics; Shelf -life; Predictability; Breeding
Sources: Web Of Science, NC State University Libraries
Added: June 11, 2024
2024 journal article
Bioactive Compounds, Antioxidant Activity, and Antiproliferative Potential on Glioblastoma Cells of Selected Stone Fruit Juices
PROCESSES, 12(7).
author keywords: iridoids; anthocyanins; antiproliferative potential; tart cherry juice; cornelian cherry juice; blackthorn juice
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 1, 2024
2024 review
Feeding the Body Through the Skin: Ethosomes and Transethosomes as a New Topical Delivery System for Bioactive Compounds
[Review of ]. ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, 15, 53–78.
author keywords: skin; ethosome; transethosome; topical administration; transdermal delivery; inflammation
Sources: Web Of Science, NC State University Libraries
Added: September 3, 2024
2024 article
Genotype and ripening method affect carotenoid content and bio-accessibility in banana
Munoz, B., Hayes, M., Perkins-Veazie, P., Gillitt, N., Munoz, M., Kay, C. D., … Iorizzo, M. (2024, March 4). FOOD & FUNCTION, Vol. 3.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 8, 2024
2024 article
Gut-derived wild blueberry phenolic acid metabolites modulate extrinsic cutaneous damage
Ivarsson, J., Bennett, A., Ferrara, F., Strauch, R., Vallase, A., Iorizzo, M., … Valacchi, G. (2024, June 6). FOOD & FUNCTION, Vol. 6.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 8, 2024
2024 article
Gut-derived wild blueberry phenolic acid metabolites modulate extrinsic cutaneous damage (vol 15, pg 7849, 2024)
Ivarsson, J., Bennett, A., Ferrara, F., Strauch, R., Vallese, A., Iorizzo, M., … Valacchi, G. (2024, October 1). FOOD & FUNCTION, Vol. 10.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 14, 2024
2024 journal article
Inference of the genetic basis of fruit texture in highbush blueberries using genome-wide association analyses
HORTICULTURE RESEARCH, 11(10).
Sources: Web Of Science, NC State University Libraries
Added: November 4, 2024
2024 journal article
Spray dried insect protein-polyphenol particles deliver health-relevant value-added food ingredients
FUTURE FOODS, 9.
author keywords: Alternative protein; Cricket; Food ingredients; Revalorization
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024
2023 review
Blueberry Supplementation and Skin Health
[Review of ]. ANTIOXIDANTS, 12(6).
author keywords: blueberries; skin; inflammation; polyphenol; antioxidant
TL;DR:
The argument for blueberries to possibly be an effective agent for skin health is built and the need for further research to elucidate the mechanisms behind the use of both topical application and dietary supplementation with blueberry to bolster cutaneous systems and defensive mechanisms is highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 14, 2023
2023 journal article
Blueberry intake elevates post-exercise anti-inflammatory oxylipins: a randomized trial
SCIENTIFIC REPORTS, 13(1).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023
2023 journal article
Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries
ANTIOXIDANTS, 12(5).
author keywords: blueberries; polyphenols; anthocyanins; precision nutrition
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 24, 2023
2023 journal article
Development of Spray Dried Spirulina Protein-Berry Pomace Polyphenol Particles to Attenuate Pollution-Induced Skin Damage: A Convergent Food-Beauty Approach
ANTIOXIDANTS, 12(7).
author keywords: sustainability; value-added; repurposing; skin health; cosmeceuticals
TL;DR:
It is demonstrated that protein-polyphenol complexation is a synergistic strategy to stabilize and deliver residual fruit/algae phytoactives into cosmeceutical products for skin health applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 17, 2023
2023 journal article
Evaluation of saffron extract bioactivities relevant to skin resilience
JOURNAL OF HERBAL MEDICINE, 37.
author keywords: Tyrosinase; Collagenase; Collagen; Hyaluronic acid; Antioxidant activity; Crocus sativus
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 14, 2023
2023 journal article
Influence of 2 Weeks of Mango Ingestion on Inflammation Resolution after Vigorous Exercise
NUTRIENTS, 16(1).
author keywords: mangoes; exercise; inflammation; metabolites; gallotannins; oxylipins; tandem mass spectrometry
TL;DR:
The 2.25 h cycling bouts induced significant inflammation, but no countermeasure effect was found after 2 weeks of mango ingestion despite the elevation of mango gut-derived phenolic metabolites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 26, 2024
2023 article
Influence of 2-Weeks Mango Ingestion on Inflammation Resolution After Vigorous Exercise
Sakaguchi, C. A., Nieman, D. C., Omar, A. M., Strauch, R. C., Williams, J. C., & Lila, M. A. (2023, November 29).
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: January 26, 2024
2023 journal article
Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial
AMERICAN JOURNAL OF CLINICAL NUTRITION, 118(2), 382–390.
author keywords: bone; blueberries; calcium; osteoporosis; polyphenols; postmenopausal
TL;DR:
Moderate consumption of blueberries may be an effective strategy to attenuate bone loss in healthy postmenopausal women and no significant relationships were found between bone resorption biomarkers, 25-hydroxyvitamin D, and interventions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023
2023 journal article
Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson's Disease
ANTIOXIDANTS, 12(7).
author keywords: anthocyanin; Nrf2; paraquat; Parkinson's disease; polyphenols; rotenone
TL;DR:
It is suggested that extracts enriched with certain combinations of ANC, PAC, stilbenes, and other polyphenols could potentially slow neurodegeneration in the brains of individuals exposed to PQ or rotenone by activating cellular antioxidant mechanisms and/or alleviating mitochondrial dysfunction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 25, 2023
2023 journal article
Spray drying to produce novel phytochemical-rich ingredients from juice and pomace of American elderberry
FOOD BIOSCIENCE, 55.
author keywords: Sambucus; Dietary supplement; Repurposing; Powder ingredients; Bioaccessibility; Phytochemicals
Sources: Web Of Science, NC State University Libraries
Added: September 18, 2023
2023 article
Spray-drying microencapsulation of blackcurrant and cocoa polyphenols using underexplored plant-based protein sources
Hoskin, R. T., Grace, M. H. H., Xiong, J., & Lila, M. A. (2023, May 9). JOURNAL OF FOOD SCIENCE, Vol. 5.
author keywords: buckwheat; chia; pea; protein; carriers; revalorization
MeSH headings : Polyphenols / chemistry; Plant Proteins / chemistry; Antioxidants / chemistry; Anthocyanins; Chocolate; Pea Proteins; Plant Extracts / chemistry; Cacao / chemistry; Phytochemicals
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 11, 2023
2022 article
Autopolyploid inheritance and a heterozygous reciprocal translocation shape chromosome genetic behavior in tetraploid blueberry (Vaccinium corymbosum)
Mengist, M. F., Bostan, H., De Paola, D., Teresi, S. J., Platts, A. E., Cremona, G., … Iorizzo, M. (2022, September 3). NEW PHYTOLOGIST, Vol. 9.
author keywords: autopolyploid; blueberry (Vaccinium corymbosum L; ); centromeric repeat; chromosomal translocation; chromosome structure; phased genome; polyploid genetic behavior
MeSH headings : Tetraploidy; Blueberry Plants / genetics; Inheritance Patterns; Polyploidy; Chromosomes
TL;DR:
A new high‐quality, phased, chromosome‐scale genome of a diploid blueberry, clone W85 is described, which will facilitate new genetic and comparative genomic studies in Vaccinium and the development of genomic assisted selection strategy for this crop.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 4, 2022
2022 article
Bioaccessibility and intestinal cell uptake of carotenoids and chlorophylls differ in powdered spinach by the ingredient form as measured using in vitro gastrointestinal digestion and anaerobic fecal fermentation models
Hayes, M., Mohamedshah, Z., Chadwick-Corbin, S., Hoskin, R., Iorizzo, M., Lila, M. A., … Ferruzzi, M. G. (2022, March 8). FOOD & FUNCTION, Vol. 13.
MeSH headings : Anaerobiosis; Caco-2 Cells; Carotenoids / metabolism; Chlorophyll; Digestion; Fermentation; Health Promotion; Humans; Powders; Spinacia oleracea / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 31, 2022
2022 article
Boosting the Bioaccessibility of Dietary Bioactives by Delivery as Protein-Polyphenol Aggregate Particles
Lila, M. A., Hoskin, R. T., Grace, M. H., Xiong, J., Strauch, R., Ferruzzi, M., … Kay, C. (2022, April 8). JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, Vol. 4.
author keywords: bioavailability; digestion; absorption; circulation; uptake; matrix
MeSH headings : Humans; Polyphenols / analysis; Fruit / chemistry; Protein Aggregates; Dietary Proteins; Biological Availability; Food Ingredients
TL;DR:
Evidence to date suggests that complexation of phy toactive polyphenolics effectively enhances their health-relevant impacts, specifically because the phytoactives are protected in the protein matrix during transit in the GIT, allowing intact, non-degraded molecules to reach the colon for catabolism at the gut microbiome level.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 14, 2022
2022 journal article
Continuous flow microwave-assisted aqueous extraction of pomace phytoactives for production of protein-polyphenol particles and a protein-enriched ready-to-drink beverage
Future Foods, 5, 100137.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: March 4, 2022
2022 article
Continuous flow microwave-assisted aqueous extraction of pomace phytoactives for production of protein-polyphenol particles and a protein-enriched ready-to-drink beverage(vol 5, artn 100137, year 2021)
Hoskin, R. T., Plundrich, N., Vargochik, A., & Lila, M. A. (2022, December). FUTURE FOODS, Vol. 6.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 6, 2023
2022 journal article
Dissecting the genetic basis of bioactive metabolites and fruit quality traits in blueberries (Vaccinium corymbosum L.)
FRONTIERS IN PLANT SCIENCE, 13.
author keywords: blueberry; anthocyanin; acylation; glycosylation; QTL mapping; candidate genes; fruit quality; chlorogenic acid
TL;DR:
The study provides the first insights into the genetic basis controlling anthocyanins accumulation and composition, chlorogenic acid and fruit quality traits, and establishes a framework to advance genetic studies and molecular breeding for anthcyanins in blueberry.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022
2022 review
Enhancing the Cognitive Effects of Flavonoids With Physical Activity: Is There a Case for the Gut Microbiome?
[Review of ]. FRONTIERS IN NEUROSCIENCE, 16.
author keywords: age-related; cognition; neuroprotective; phenolic metabolites; prebiotic flavonoids; exercise; microbiome
TL;DR:
There is a potential for combined impacts of flavonoids intake and physical exertion on cognitive function, as modulated by the gut microbiome, and that the combination of a flavonoid-rich diet and routine aerobic exercise may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the Gut microbiome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 28, 2022
2022 article
Protein-binding approaches for improving bioaccessibility and bioavailability of anthocyanins
Wu, H., Oliveira, G., & Lila, M. A. (2022, November 18). COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, Vol. 11.
author keywords: anthocyanin-protein complexes; bioavailability; digestibility; gastrointestinal; pigments
MeSH headings : Animals; Humans; Anthocyanins / chemistry; Biological Availability; Protein Binding; Food
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 19, 2022
2022 article
Six-month intervention with wild blueberries improved speed of processing in mild cognitive decline: a double-blind, placebo-controlled, randomized clinical trial
Cheatham, C. L., Canipelll, L. G., Millsap, G., Stegall, J. M., Chai, S. C., Sheppard, K. W., & Lila, M. A. (2022, September 8). NUTRITIONAL NEUROSCIENCE, Vol. 9.
author keywords: aging; CANTAB; event-related potentials; flavonoids; mild cognitive decline; speed of processing; polyphenols; wild blueberries
TL;DR:
Consumption of wild blueberries for six months improves cognitive aging sequelae by improving the speed of information processing in older adults by restoring speed of processing to the level of the reference group.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 19, 2022
2022 journal article
Spray-dried and freeze-dried protein-spinach particles; effect of drying technique and protein type on the bioaccessibility of carotenoids, chlorophylls, and phenolics
FOOD CHEMISTRY, 388.
author keywords: Spinach phytochemicals; Whey protein; Soy protein; Drying; In vitro digestion; Dried ingredients
MeSH headings : Carotenoids / metabolism; Chlorophyll / metabolism; Digestion; Excipients / metabolism; Flavonoids / metabolism; Freeze Drying; Phenols / metabolism; Spinacia oleracea / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 13, 2022
2022 journal article
There and back again; historical perspective and future directions for Vaccinium breeding and research studies
HORTICULTURE RESEARCH, 9.
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 1, 2022
2021 journal article
Alaskan Bog Blueberry (Vaccinium uliginosum) Extract as an Innovative Topical Approach to Prevent UV-Induced Skin Damage
COSMETICS, 8(4).
author keywords: cosmeceuticals; environmental stressor; oxidation; inflammation; antioxidant; OxInflammation; phytochemicals
TL;DR:
It is observed that the topical application of BB extract on human ex vivo skin explants averted the UV-induced cutaneous OxInflammatory phenomenon by quenching the increase in the oxidative and inflammatory marker levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 2, 2021
2021 journal article
Cutaneous antimicrobial peptides: New “actors” in pollution related inflammatory conditions
Redox Biology, 41, 101952.
author keywords: Skin; LL37; ROS; Antimicrobial peptides; Pollution
MeSH headings : Humans; Hydrogen Peroxide; Keratinocytes; Pore Forming Cytotoxic Proteins; Skin; Skin Diseases
TL;DR:
Exposure to O3 is hypothesized to contribute to various cutaneous inflammatory conditions, such as eczema, psoriasis, rush etc via a redox-inflammatory pathway and altered levels of AMPs are observed, suggesting that targeting AMPs could be a possible defensive strategy to combat pollution-associated skin conditions.
(via Semantic Scholar)
Source: ORCID
Added: April 1, 2021
2021 journal article
Efficacy of Pecan Husk and Shell Phenolic Extracts Against Phytophthora Blight in Chile Pepper
PLANT HEALTH PROGRESS, 22(3), 342–347.
author keywords: Phytophthora capsici; Capsicum annuum; induced resistance; elicitors; proanthocyanidins; soilborne pathogens
TL;DR:
Pecan byproducts may be used as additional options for management of Phytophthora blight and the phenolic content in the extracts was largely made up of proanthocyanidins also known as condensed tannins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 18, 2022
2021 journal article
Foaming and sensory characteristics of protein-polyphenol particles in a food matrix
Food Hydrocolloids.
author keywords: Particles; Polyphenols; Proteins; Foaming; Sensory; Structure
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 26, 2021
2021 review
Gains and Losses of Agricultural Food Production: Implications for the Twenty-First Century
[Review of ]. ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, 13, 239–261.
author keywords: agricultural food systems; genetic improvement; biofortification; phytochemicals; alternative proteins; sustainable agriculture
MeSH headings : Agriculture; Animals; Biodiversity; Climate Change; Crops, Agricultural; Food Supply
TL;DR:
This review introduces the concept of agricultural food systems losses and focuses on improved sources of agricultural diversity, proteins with enhanced resilience, and novel monitoring, processing, and distribution technologies that are poised to improve food security, reduce food loss and waste, and improve health profiles in the near future.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science; OpenAlex)
3. Good Health and Well-being
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 23, 2022
2021 journal article
High-density linkage map construction and identification of loci regulating fruit quality traits in blueberry
HORTICULTURE RESEARCH, 8(1).
TL;DR:
The genetic basis of fruit quality traits in blueberry was dissected and an association between these fruit quality trait and metabolites detected by Proton nuclear magnetic resonance analysis was established.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 1, 2021
2021 article
Influence of simulated food and oral processing on carotenoid and chlorophyll in vitro bioaccessibility among six spinach genotypes
Hayes, M., Corbin, S., Nunn, C., Pottorff, M., Kay, C. D., Lila, M. A., … Ferruzzi, M. G. (2021, May 14). FOOD & FUNCTION, Vol. 5.
MeSH headings : Biological Availability; Carotenoids / chemistry; Carotenoids / metabolism; Carotenoids / pharmacokinetics; Chlorophyll / chemistry; Chlorophyll / metabolism; Chlorophyll / pharmacokinetics; Digestion; Genotype; Models, Biological; Spinacia oleracea / chemistry; Spinacia oleracea / genetics
TL;DR:
It is suggested that the genotype, processing treatment, and genotype × processing (G × P) interaction may affect carotenoid and chlorophyll bioaccessibility in spinach and that food processing remains a dominant factor in modulating the bioavailability of these phytochemicals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 22, 2021
2021 article
Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models
Jacquet, A. de R., Ambaw, A., Tambe, M. A., Ma, S. Y., Timmers, M., Grace, M. H., … Rochet, J.-C. (2021, July 16). FOOD & FUNCTION, Vol. 7.
MeSH headings : Animals; Astrocytes / drug effects; Cells, Cultured; Dietary Supplements; Dopaminergic Neurons / drug effects; Female; Humans; Isoflavones / pharmacology; Male; Models, Biological; Neuroprotective Agents / pharmacology; Parkinson Disease / metabolism; Phytochemicals / pharmacology; Rats; Rats, Sprague-Dawley; Soybeans / chemistry; Trifolium / chemistry
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 10, 2021
2021 journal article
Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage
MOLECULES, 26(13).
author keywords: cosmeceuticals; pollution; phytochemicals; herbs
MeSH headings : Antioxidants / chemistry; Antioxidants / pharmacology; Cells, Cultured; Chlorella / chemistry; Cinnamates / chemistry; Depsides / chemistry; Environmental Exposure / adverse effects; Filaggrin Proteins; Humans; Rosmarinus / chemistry; Skin / injuries; Skin / metabolism; Skin / pathology; Skin Aging / drug effects
TL;DR:
The ex-vivo data clearly demonstrated the ability of RSP gel to prevent an oxinflammatory phenomenon in cutaneous tissue by decreasing the levels of 4-hydroxynonenal protein adducts and active matrix metalloproteinase-9 (MMP-9) by limiting the loss of filaggrin induced by DEE exposure.
(via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 23, 2021
2021 article
Pea protein isolate characteristics modulate functional properties of pea protein-cranberry polyphenol particles
Strauch, R. C., & Lila, M. A. (2021, May 24). FOOD SCIENCE & NUTRITION, Vol. 5.
author keywords: by-products; cranberry polyphenols; digestion; pea protein isolate; solubility
TL;DR:
Plant polyphenols have a natural binding affinity for proteins, and their interaction can be exploited to form diverse aggregate particles to allow consumers to incorporate more health‐benefiting plant bioactives into their diets.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 25, 2021
2021 journal article
Phytoecdysteroids Do Not Have Anabolic Effects in Skeletal Muscle in Sedentary Aging Mice
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18(2).
author keywords: skeletal muscle; hypertrophy; Akt; atrogenes; 20-hydroxyecdysone
MeSH headings : Aging; Anabolic Agents; Animals; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Rats
TL;DR:
Data indicate that phytoecdysteroid treatment does not alter muscle mass or fiber type, nor does it activate protein synthesis signaling in the skeletal muscle of sedentary aging mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 7, 2021
2021 review
The berry health tool chest - an evidence map and interactive resource
[Review of ]. NUTRITION REVIEWS, 80(1), 68–77.
author keywords: berry; clinical trial design; dietary intervention; evidence mapping; health criteria
MeSH headings : Eating; Fruit; Humans
TL;DR:
The development and utility of the "Berry Health Tool Chest," an evidence map summarizing trial design features of studies characterizing the impact of berry consumption upon human health biomarkers, are described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2022
2021 journal article
Whey and soy proteins as wall materials for spray drying rosemary: Effects on polyphenol composition, antioxidant activity, bioaccessibility after in vitro gastrointestinal digestion and stability during storage
LWT-FOOD SCIENCE AND TECHNOLOGY, 149.
author keywords: Protein-polyphenol; Phenolic diterpenes; Bioaccessibility; Rosemary antioxidants; Spray-drying
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 16, 2021
2020 journal article
Blueberry Extracts as a Novel Approach to Prevent Ozone-Induced Cutaneous Inflammasome Activation
Oxidative Medicine and Cellular Longevity.
MeSH headings : Biopsy; Blueberry Plants / chemistry; Cell Death / drug effects; Cell Movement / drug effects; Cell Proliferation / drug effects; HaCaT Cells; Humans; Hydrogen Peroxide / metabolism; Inflammasomes / metabolism; Keratinocytes / drug effects; Keratinocytes / pathology; Models, Biological; Oxidative Stress / drug effects; Ozone / toxicity; Plant Extracts / pharmacology; Protein Multimerization / drug effects; Skin / drug effects; Skin / pathology
TL;DR:
The hypothesis that blueberry (BB) extract can effectively reduce skin inflammation and be a possible new technology against cutaneous pollution-induced damage is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: ORCID
Added: August 15, 2020
2020 journal article
Blueberry and/or Banana Consumption Mitigate Arachidonic, Cytochrome P450 Oxylipin Generation During Recovery From 75-Km Cycling: A Randomized Trial
FRONTIERS IN NUTRITION, 7.
author keywords: exercise; lipid mediators; carbohydrate; polyphenols; metabolites; inflammation; fatty acids
TL;DR:
Heavy exertion evoked a transient but robust increase in plasma levels of oxylipins in cyclists, with a strong attenuation effect linked to both chronic blueberry and acute banana intake on pro-inflammatory ARA-CYP oxylIPins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 21, 2020
2020 article
Building a Resilient, Sustainable, and Healthier Food Supply Through Innovation and Technology
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 12, 2021, Vol. 12, pp. 1–28.
author keywords: future foods; food production; food processing; environmental impacts; nanotechnology; gene editing; genetic engineering; artificial intelligence; robotics
MeSH headings : Agriculture; Artificial Intelligence; Biotechnology; COVID-19; Food Quality; Food Safety; Food Supply / standards; Humans; Nanotechnology; Pandemics; Robotics
TL;DR:
A perspective article, written by members of the Editorial Committee of the Annual Review of Food Science and Technology, highlights some of the major challenges confronting the modern food supply chain as well as how innovations in policy and technology can be used to address them.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 24, 2021
2020 article
Chemical Composition and Bioactive Properties of Commercial and Non-Commercial Purple and White Açaí Berries
Matta, F. V., Xiong, J., Lila, M. A., Ward, N. I., Felipe-Sotelo, M., & Esposito, D. (2020, September 29). (Vol. 9). Vol. 9.
Source: ORCID
Added: October 1, 2020
2020 journal article
Chemical Composition and Bioactive Properties of Commercial and Non-Commercial Purple and White Açaí Berries
Foods, 9(10), 1481.
author keywords: acai; total polyphenol; total anthocyanin; antioxidant; elemental analysis; essential elements; biological activity; wound healing
TL;DR:
All the açaí samples demonstrated potential as wound healing agents due to the high levels of migration activity in human fibroblast cells, and presented significant levels of calcium, magnesium, manganese, iron, zinc and copper, essential minor and trace elements, in comparison with other berries.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: October 23, 2020
2020 journal article
Development of a genetic framework to improve the efficiency of bioactive delivery from blueberry
SCIENTIFIC REPORTS, 10(1).
MeSH headings : Blueberry Plants / genetics; Blueberry Plants / metabolism; Digestion; Flavonoids / metabolism; Genotype; Hydroxybenzoates / metabolism; In Vitro Techniques
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 16, 2020
2020 journal article
Enhanced stability of berry pomace polyphenols delivered in protein-polyphenol aggregate particles to an in vitro gastrointestinal digestion model
Food Chemistry, 331, 127279.
Contributors: J. Xiong n , Y. Chan n, T. Rathinasabapathy , M. Grace n , S. Komarnytsky n & n
author keywords: Food matrix; By-product; Stability; Antioxidant; Anti-inflammatory
MeSH headings : Animals; Anthocyanins / analysis; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Antioxidants / analysis; Blueberry Plants / chemistry; Digestion; Food-Processing Industry; Fruit / chemistry; Mice; Plant Extracts / chemistry; Plant Extracts / pharmacokinetics; Plant Proteins, Dietary / chemistry; Polyphenols / pharmacokinetics; Proanthocyanidins / analysis; RAW 264.7 Cells; Vitis / chemistry
TL;DR:
Protein-polyphenol particle digests retained 1.5 to 2-fold higher antioxidant capacity and suppressed the expression of pro-inflammatory cytokines, iNOS, IL6, and IL1β, compared to unmodified extract digests, which only suppressed IL6.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: June 19, 2020
2020 journal article
Formulation of protein–polyphenol particles for applications in food systems
Food & Function.
MeSH headings : Blueberry Plants / chemistry; Chemical Phenomena; Fruit / chemistry; Fruit and Vegetable Juices; Functional Food; Oryza; Particle Size; Plant Proteins, Dietary / chemistry; Polyphenols / chemistry; Vaccinium macrocarpon / chemistry; Whey Proteins / chemistry
TL;DR:
Particles formed with whey protein and blueberry juice significantly improved foam stability and drainage half-life and protein-polyphenol particles can be designed as ingredients to stabilize food structures and to increase delivery of health protective polyphenols and proteins in the diet.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 30, 2020
2020 journal article
Hypoglycaemic, insulin releasing, and hepatoprotective effect of the aqueous extract of Aloe perryi Baker resin (Socotran Aloe) in streptozotocin-induced diabetic rats
Journal of Taibah University for Science, 14(1), 1671–1685.
author keywords: Aloe perryi; polyphenols; anti-diabetic; anti-hyperlipidemia; ALT; AST
TL;DR:
In conclusion, AP extract exerts hypoglycaemic, insulin-releasing, and hepatic antioxidant potentials in diabetic rats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: December 13, 2020
2020 journal article
In Vitro Bioaccessibility of Carotenoids and Chlorophylls in a Diverse Collection of Spinach Accessions and Commercial Cultivars
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68(11), 3495–3505.
author keywords: spinach; carotenoids; lutein; beta-carotene; chlorophyll; genotypes; bioaccessibility; in vitro digestion
MeSH headings : Carotenoids; Chlorophyll; Chlorophyll A; Spinacia oleracea / genetics; beta Carotene
TL;DR:
The results suggest that carotenoid and chlorophyll bioaccessible contents may vary based on spinach genotypes and may be stable across seasons.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 8, 2020
2020 journal article
LC-MS characterization of bioactive metabolites from two Yemeni Aloe spp. with antioxidant and antidiabetic properties
ARABIAN JOURNAL OF CHEMISTRY, 13(4), 5040–5049.
Contributors: T. Aldayel *, M. Grace n , n , M. Yahya *, U. Omar * & G. Alshammary*
author keywords: LC-ESI-IT-TOF; Aloe; Phenolics; alpha-Glucosidase inhibition; Antioxidant activity
TL;DR:
Findings highlight the phytochemical profile, antioxidant and potential antidiabetic activity of the Yemeni Aloe species and draw attention to their potential application in food, medicine and cosmetic products.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 20, 2020
2020 journal article
Phenolic content, anti-inflammatory properties, and dermal wound repair properties of industrially processed and non-processed acai from the Brazilian Amazon
Food & Function, 11(6), 4903–4914.
Contributors: J. Xiong n , F. Matta *, M. Grace n , n , N. Ward *, M. Felipe-Sotelo *, D. Esposito n
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Arecaceae; Brazil; Food Industry; Fruit; Humans; Mice; Phytotherapy; Plant Extracts / chemistry; Plant Extracts / pharmacology; Polyphenols / chemistry; RAW 264.7 Cells / drug effects; Wound Healing / drug effects
TL;DR:
The anti-inflammatory effect was diminished but wound healing effect was retained after pulp processing, suggesting the processing technology needs to be improved to maintain biological properties of acai fruit.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: June 5, 2020
2020 journal article
Skeletal Protection and Promotion of Microbiome Diversity by Dietary Boosting of the Endogenous Antioxidant Response
JOURNAL OF BONE AND MINERAL RESEARCH, 36(4), 768–778.
author keywords: NUTRITION; GENETIC ANIMAL MODELS; SEX STEROIDS; OSTEOPOROSIS; THERAPEUTICS— OTHER
MeSH headings : Animals; Antioxidants; Bone and Bones; Diet; Female; Humans; Male; Mice; Microbiota; Phylogeny
TL;DR:
A blueberry cultivar that added to the diet protects female mice from musculoskeletal loss and body weight changes induced by ovariectomy and elicits antioxidant defense responses independently of classical antioxidant/estrogenic signaling, and increases gut microbiome diversity toward a healthier signature.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 19, 2021
2020 article
Skin Health from the Inside Out
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 11, Vol. 11, pp. 235–254.
author keywords: pollution; skin; diet; GI tract; inflammation; antioxidant; vitamins
MeSH headings : Antioxidants / metabolism; Humans; Reactive Oxygen Species / metabolism; Skin Physiological Phenomena
TL;DR:
This review discusses how topical application of antioxidants, including vitamins C and E, carotenoids, resveratrol, and pycnogenol, can be combined with dietary supplementation of these antioxidant compounds in addition to probiotics and essential minerals to protect against outdoor stressor-induced skin damage, including the damage associated with aging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020
2020 article
The Colors of Health: Chemistry, Bioactivity, and Market Demand for Colorful Foods and Natural Food Sources of Colorants
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 11, Vol. 11, pp. 145–182.
author keywords: anthocyanins; betalains; bioactivity; carotenoids; natural colors; phycocyanins
MeSH headings : Color; Food; Pigments, Biological / chemistry
TL;DR:
The color industry needs new sources of stable, functional, and safe natural food colorants, and new opportunities include sourcing new colors from microbial sources and via the use of genetic biotechnology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020
2020 journal article
The same anthocyanins served four different ways: Insights into anthocyanin structure-function relationships from the wintergreen orchid, Tipularia discolor
PLANT SCIENCE, 303.
author keywords: Abaxial/adaxial anthocyanins; Acylated cyanidin; 3,7,3 '-Triglucoside; Camouflage; Chemotaxonomy; Leaf color evolution; Herbivory defense
MeSH headings : Anthocyanins / chemistry; Anthocyanins / isolation & purification; Anthocyanins / physiology; Chromatography, High Pressure Liquid; Color; Gas Chromatography-Mass Spectrometry; Microscopy; Orchidaceae / metabolism; Orchidaceae / ultrastructure; Plant Leaves / metabolism; Plant Leaves / ultrastructure; Structure-Activity Relationship
TL;DR:
The results showed that the same three cyanidin 3,7,3'-triglucosides, in similar concentrations and proportions, accounted for coloration in each of these cases, and served as a reminder that plants may employ the same anthocyanins in different anatomical locations to achieve a broad range of colors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 11, 2020
2020 journal article
Whey protein-polyphenol aggregate particles mitigate bar hardening reactions in high protein bars
LWT-FOOD SCIENCE AND TECHNOLOGY, 138.
author keywords: Protein bar; Texture; Polyphenol; Particle; Microstructure
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 15, 2021
2019 journal article
Alaskan Berry Extracts Promote Dermal Wound Repair Through Modulation of Bioenergetics and Integrin Signaling
FRONTIERS IN PHARMACOLOGY, 10(SEP).
Contributors: D. Esposito n , J. Overall n , M. Grace n , S. Komarnytsky n & n
author keywords: skin regeneration; wound healing; Alaskan berries; integrins; proanthocyanidins; epicatechins
TL;DR:
Targeting cellular bioenergetics and integrin-mediated cell–ECM signaling with bioactives from Alaskan wild berries shows considerable therapeutic promise to treat chronic skin wounds and inflammatory skin disorders, as well as more generally to support regenerative healing responses and restore function in a variety of tissue and organ settings after injury or aging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 14, 2019
2019 journal article
Binding of peanut allergen Ara h 2 with Vaccinium fruit polyphenols
FOOD CHEMISTRY, 284, 287–295.
author keywords: Ara h 2; Molecular docking; Polyphenol; IgE binding; Circular dichroism (CD); Food allergy
MeSH headings : 2S Albumins, Plant / chemistry; 2S Albumins, Plant / immunology; 2S Albumins, Plant / metabolism; Antigens, Plant / chemistry; Antigens, Plant / immunology; Antigens, Plant / metabolism; Arachis / metabolism; Biflavonoids / chemistry; Biflavonoids / metabolism; Binding Sites; Catechin / chemistry; Catechin / metabolism; Chlorogenic Acid / chemistry; Chlorogenic Acid / metabolism; Circular Dichroism; Epitopes / chemistry; Epitopes / metabolism; Fruit / chemistry; Fruit / metabolism; Glycoproteins / chemistry; Glycoproteins / immunology; Glycoproteins / metabolism; Humans; Immunoglobulin E / chemistry; Immunoglobulin E / metabolism; Molecular Docking Simulation; Polyphenols / chemistry; Polyphenols / metabolism; Proanthocyanidins / chemistry; Proanthocyanidins / metabolism; Protein Binding; Protein Structure, Secondary; Spectrophotometry; Vaccinium / chemistry; Vaccinium / metabolism
TL;DR:
Results suggest that certain polyphenols can inhibit IgE recognition of Ara h 2 by obstructing linear IgE epitopes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 25, 2019
2019 article
Blueberries Topical Application Prevents Ozone Induced Cutaneous Inflammasome Activation
Pambianchi, E., Francesca, F., Pecorelli, A., Woodby, B., Lila, M., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S148–S148.
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019
2019 journal article
Changes in the bioactive properties of strawberries caused by the storage in oxygen- and carbon dioxide-enriched atmospheres
FOOD SCIENCE & NUTRITION, 7(8), 2527–2536.
Contributors: F. Velde *, D. Esposito n , J. Overall n , M. Méndez-Galarraga*, M. Grace n , M. Élida Pirovani *, n
author keywords: 2; 2-diphenyl-1-picrylhydrazil; cyclooxygenase-2; ferric reducing antioxidant power; human dermal fibroblast migration; interleukin-6; modified atmosphere storage
TL;DR:
Evidence suggests that strawberry storage in 90% O2 + 10% CO2 can be a promissory alternative to offer fruits with enhanced bioactivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 5, 2019
2019 journal article
Comparison of berry juice concentrates and pomaces and alternative plant proteins to produce spray dried protein–polyphenol food ingredients
Food & Function, 10(10), 6286–6299.
Contributors: R. Hoskin n, J. Xiong n & n
MeSH headings : Animals; Blueberry Plants / chemistry; Color; Fagopyrum / chemistry; Flour / analysis; Food Handling; Food Ingredients / analysis; Fruit / chemistry; Fruit and Vegetable Juices / analysis; Peas / chemistry; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Proteins / chemistry; Plant Proteins / isolation & purification; Polyphenols / chemistry; Polyphenols / isolation & purification; Vaccinium macrocarpon / chemistry; Vitis / chemistry; Waste Products / analysis
TL;DR:
The results suggest an efficient plant-based approach to produce value-added protein-polyphenol aggregates with broad utility as healthy food ingredients as well as good spray drying yield.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: November 4, 2019
2019 article
Immunometabolism: A Multi-Omics Approach to Interpreting the Influence of Exercise and Diet on the Immune System
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 10, Vol. 10, pp. 341–363.
author keywords: exercise; diet; immune function; metabolomics; lipidomics; proteomics
MeSH headings : Diet; Exercise; Humans; Immune System; Metabolism
TL;DR:
Emerging evidence using large multi-omics data sets supports the combined intake of fruit sugars and phytochemicals by athletes during heavy exertion as an effective strategy to improve metabolic recovery, augment viral defense, and counter postexercise inflammation and immune dysfunction at the cell level.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 22, 2019
2019 journal article
Peanut protein-polyphenol aggregate complexation suppresses allergic sensitization to peanut by reducing peanut-specific IgE in C3H/HeJ mice
FOOD CHEMISTRY, 299.
author keywords: Peanut allergy; IgE; CD63; Polyphenol; Blueberry; Cranberry
MeSH headings : Animals; Arachis / chemistry; Arachis / immunology; Female; Immunoglobulin E / immunology; Mice; Mice, Inbred C3H; Peanut Hypersensitivity / prevention & control; Plant Proteins / chemistry; Plant Proteins / immunology; Polyphenols / chemistry; Species Specificity
TL;DR:
It is demonstrated for the first time that complexation of polyphenols to peanut flour can potentially lower plasma IgE of peanut-sensitized C3H/HeJ mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019
2019 journal article
Photosynthetic Profiles of Green, Purple, and Spotted-Leaf Morphotypes of Tipularia discolor (Orchidaceae)
SOUTHEASTERN NATURALIST, 18(4), 641–658.
Contributors: N. Hughes *, G. Gigantino*, M. Grace n , K. Hoffman*, n , B. Willans*, A. Wommack *
TL;DR:
It is concluded that leaf purpling and spotting in Cranefly Orchid are most likely not related to physiological stress, and are more likely genetic in nature, perhaps representing alternative phenotypic adaptations related to herbivory defense.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 6, 2020
2019 journal article
Redox regulation of cutaneous inflammasome by ozone exposure
FREE RADICAL BIOLOGY AND MEDICINE, 152, 561–570.
MeSH headings : Caspase 1 / metabolism; Humans; Hydrogen Peroxide; Inflammasomes / metabolism; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Oxidation-Reduction; Ozone / toxicity; Reactive Oxygen Species
TL;DR:
It is demonstrated that O3 can activate cutaneous inflammasome in a redox dependent manner suggesting a possible role of this new pathway in pollution induced inflammatory skin conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 13, 2020
2019 journal article
Variation in anthocyanin profiles of 27 genotypes of red cabbage over two growing seasons
FOOD CHEMISTRY, 301.
author keywords: Red cabbage; Acylated anthocyanin; Breeding population; HPLC-DAD-MSE
MeSH headings : Acylation; Anthocyanins / analysis; Anthocyanins / chemistry; Brassica / chemistry; Brassica / genetics; Brassica / metabolism; Chromatography, High Pressure Liquid; Genotype; Mass Spectrometry; Plant Breeding; Polymorphism, Genetic; Seasons
TL;DR:
PCA analysis identified anthocyanin accumulation traits and genotypes with high diversity which can be utilized in future investigations into the genetic and molecular basis for anthochenin production, acylation, and diversity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 23, 2019
2018 journal article
Anti-inflammatory and wound healing properties of polyphenolic extracts from strawberry and blackberry fruits
FOOD RESEARCH INTERNATIONAL, 121, 453–462.
Contributors: F. Velde *, D. Esposito n , M. Grace n , M. Pirovani * & n
author keywords: Fragaria ananassa; Rubus fruticosus; Anthocyanins; Proanthocyanidins; Cyclooxygenase-2; Interleukin-6; Skin cell migration
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Anti-Inflammatory Agents / analysis; Anti-Inflammatory Agents / pharmacology; Antioxidants / analysis; Antioxidants / pharmacology; Cell Movement / drug effects; Cell Proliferation / drug effects; Cell Survival / drug effects; Chromatography, High Pressure Liquid; Fragaria / chemistry; Fruit / chemistry; Mice; Phytochemicals / analysis; Phytochemicals / pharmacology; Plant Extracts / analysis; Plant Extracts / pharmacology; Polyphenols / analysis; Polyphenols / pharmacology; Proanthocyanidins / analysis; Proanthocyanidins / pharmacology; RAW 264.7 Cells; Reactive Oxygen Species / metabolism; Rubus / chemistry; Wound Healing / drug effects
TL;DR:
Results obtained in this work highlight the anti-inflammatory properties of berry polyphenolics, especially due to proanthocyanidins, and promising results were obtained about the effects of bberry anthocyanins on wound healing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2019
2018 article
AtmO(3)spheric skin damage: The oxInflammation phenomena
Valacchi, G., Pecorelli, A., Pambianchi, E., Ferrara, F., & Lila, M. (2018, September). JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 138, pp. B15–B15.
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2018
2018 journal article
Blueberry polyphenol-protein food ingredients: The impact of spray drying on the in vitro antioxidant activity, anti-inflammatory markers, glucose metabolism and fibroblast migration
Food Chemistry, 280, 187–194.
Contributors: R. Hoskin n, J. Xiong n , D. Esposito n & n
author keywords: Berries; By-products; Drying; Inflammation; Phytochemicals
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Blueberry Plants / chemistry; Blueberry Plants / metabolism; Cell Line; Cell Movement / drug effects; Cell Survival / drug effects; Cyclooxygenase 2 / metabolism; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Freeze Drying; Glucose / metabolism; Interleukin-1beta / metabolism; Macrophages / cytology; Macrophages / drug effects; Macrophages / metabolism; Mice; Plant Proteins / chemistry; Plant Proteins / pharmacology; Polyphenols / chemistry; Polyphenols / pharmacology; Protein Aggregates; RAW 264.7 Cells; Rats; Reactive Oxygen Species / metabolism
TL;DR:
The data suggests that spray drying is a convenient and cost-effective technique to produce blueberry-polyphenol food ingredients with preserved phytochemicals with biological activities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: January 28, 2019
2018 journal article
Changes due to high oxygen and high carbon dioxide atmospheres on the general quality and the polyphenolic profile of strawberries
Postharvest Biology and Technology, 148, 49–57.
Contributors: F. Velde *, M. Méndez-Galarraga*, M. Grace n , C. Fenoglio *, n & M. Pirovani *
author keywords: Modified atmosphere packaging; Abiotic stress; Anthocyanins; Phenolic acids; Ellagitannins; Vitamin C
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019
2018 journal article
In vitro mineral nutrition of Curcuma longa L. affects production of volatile compounds in rhizomes after transfer to the greenhouse
BMC Plant Biology, 18.
Source: NC State University Libraries
Added: August 6, 2018
2018 article
In vitro mineral nutrition of Curcuma longa L. affects production of volatile compounds in rhizomes after transfer to the greenhouse (vol 18, 122, 2018)
BMC Plant Biology, Vol. 18.
Source: NC State University Libraries
Added: August 6, 2018
2018 article
Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following 2-Weeks Flavonoid Supplementation
Nieman, D. C., Kay, C. D., Rathore, A. S., Grace, M. H., Strauch, R. C., Stephan, E. H., … Lila, M. A. (2018, October 15). (Vol. 10). Vol. 10.
Source: ORCID
Added: November 13, 2019
2018 journal article
Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following Two Weeks of Flavonoid Supplementation
Nutrients, 10(11).
Contributors: D. Nieman *, C. Kay n , A. Rathore n, M. Grace n , R. Strauch n, E. Stephan*, C. Sakaguchi *, n
author keywords: exercise; polyphenol; metabolite; hippurate; intestinal tract; colon
TL;DR:
Data indicate that acute exercise bouts (brisk walking, intensive running) are linked to an increased translocation of gut-derived phenolics into circulation, an effect that is amplified when combined with a two-week period of increased flavonoid intake or chronic training as a runner.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: November 12, 2019
2018 journal article
Peanut flour aggregation with polyphenolic extracts derived from peanut skin inhibits IgE binding capacity and attenuates RBL-2H3 cells degranulation via MAPK signaling pathway
FOOD CHEMISTRY, 263, 307–314.
author keywords: Peanut skin; Peanut flour; Peanut allergy; Degranulation; Polyphenols; RBL-2H3 cells
MeSH headings : Allergens / immunology; Allergens / metabolism; Animals; Arachis / chemistry; Arachis / metabolism; Basophils / cytology; Basophils / drug effects; Basophils / metabolism; Cell Degranulation / drug effects; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Histamine / metabolism; Immunoglobulin E / analysis; Immunoglobulin E / immunology; MAP Kinase Signaling System / drug effects; Plant Proteins / immunology; Plant Proteins / metabolism; Polyphenols / chemistry; Polyphenols / pharmacology; Rats
TL;DR:
Results show that aggregation of PSP to PN proteins reduces allergic response by inhibiting Ca2+-induced MAPK-dependent cell degranulation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2018 article
Protein-polyphenol particles for delivering structural and health functionality (Reprinted from Food Hydrocolloids, vol 72, pg 163-173, 2017)
Foegeding, E. A., Plundrich, N., Schneider, M., Campbell, C., & Lila, M. A. (2018, May). FOOD HYDROCOLLOIDS, Vol. 78, pp. 15–25.
author keywords: Protein; Polyphenols; Colloidal aggregates; Health, and Structural Functionality
TL;DR:
The overall goal should be a rational design of protein-polyphenol particles to ensure a positive contribution to food quality, protein nutrition, and delivery of a health-relevant dose of polyphenols to the gastrointestinal tract.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2018 journal article
SR-B1 involvement in keratinocytes in vitro wound closure
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 658, 1–6.
author keywords: Wound healing; Skin; Proliferation; Migration
MeSH headings : Cell Line, Transformed; Cell Movement / physiology; Cell Proliferation / physiology; Cyclin D1 / metabolism; Gene Knockout Techniques; Humans; Keratinocytes / cytology; Keratinocytes / physiology; Matrix Metalloproteinase 9 / metabolism; NF-kappa B p50 Subunit / metabolism; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / physiology; Skin / metabolism; Wound Healing / physiology
TL;DR:
In vitro data demonstrated that SR-B1 influenced keratinocyte proliferation and migration through a downregulation of nuclear cyclin D1 levels and active MMP9 expression respectively possibly in an NF-kB-dependent mechanism, and suggests a new role of SRB1 as a possible new key player in cutaneous wound healing mechanism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 26, 2018
2018 journal article
Simultaneous LC-MS quantification of anthocyanins and non-anthocyanin phenolics from blueberries with widely divergent profiles and biological activities
Food Chemistry, 277, 336–346.
Contributors: M. Grace n , J. Xiong n , D. Esposito n , M. Ehlenfeldt * & n
author keywords: Pink-fruited; Blueberries; LC-IT-TOF-MS; Quantification; Antioxidant; Anti-inflammatory; PCA
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Anti-Inflammatory Agents / analysis; Anti-Inflammatory Agents / pharmacology; Antioxidants / analysis; Antioxidants / pharmacology; Biological Assay; Blueberry Plants / chemistry; Cell Survival / drug effects; Chromatography, Liquid; Color; Flavonoids / analysis; Flavonoids / pharmacology; Flavonols / analysis; Flavonols / pharmacology; Fruit / chemistry; Hydroxybenzoates / analysis; Hydroxybenzoates / pharmacology; Limit of Detection; Mass Spectrometry; Mice; Nitric Oxide / metabolism; Phenols / analysis; Phenols / pharmacology; Plant Extracts / analysis; Plant Extracts / pharmacology; RAW 264.7 Cells; Reactive Oxygen Species / metabolism; Reproducibility of Results; Resveratrol / analysis; Resveratrol / pharmacology
TL;DR:
A sensitive and straightforward LC-IT-TOF-MS method was validated for the profiling and simultaneous quantification of anthocyanins, flavan-3-ols, flavonols, phenolic acids, and resveratrol in blueberry genotypes with fruit color ranging from deep purple to various shades of pink.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 17, 2018
2018 journal article
Tropospheric ozone affects SRB1 levels via oxidative post-translational modifications in lung cells
FREE RADICAL BIOLOGY AND MEDICINE, 126, 287–295.
MeSH headings : A549 Cells; Aldehydes / metabolism; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Antioxidants / pharmacology; Biological Transport / drug effects; Catalase / genetics; Catalase / metabolism; Cell Survival / drug effects; Humans; Hydrogen Peroxide / metabolism; Lung / drug effects; Lung / metabolism; Lung / pathology; Oxidation-Reduction / drug effects; Oxidative Stress / drug effects; Ozone / pharmacology; Protein Processing, Post-Translational / drug effects; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / metabolism; Vitamin E / metabolism
TL;DR:
To characterize the molecular mechanism involved in the redox modulation of SRB1, its cellular levels were assessed in human alveolar epithelial cells after O3 exposure and it was demonstrated that O3 induced the loss ofSRB1 protein levels, a mechanism that could account for SRB 1 protein loss.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018
2017 journal article
Anthocyanins in metabolic health and disease
Nutrigenomics and Proteomics in Health and Disease: towards a Systems-Level Understanding of Gene-Diet Interactions, 2nd Edition, 92–124.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage
FOOD AND CHEMICAL TOXICOLOGY, 111, 445–453.
author keywords: Bioactive food components; Polyphenols; Obesity; Diabetes; Bioenergetics; Functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Diet; Diet, High-Fat / adverse effects; Energy Metabolism; Fruit / chemistry; Lipid Metabolism; Male; Metabolic Diseases; Methylation; Mice; Mice, Inbred C57BL; Rubus / chemistry
TL;DR:
It is shown that consumption of berries containing anthocyanins with enhanced methylation profiles (malvidin and petunidin) is more effective at reducing high fat diet-induced metabolic damage in the C57BL/6 mouse model of polygenic obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Development, and genetic and metabolic characterization of new tomato mutants with enhanced and deficient carotenoid content
JOURNAL OF HORTICULTURAL SCIENCE & BIOTECHNOLOGY, 92(5), 475–483.
author keywords: Carotenoid; lycopene; -carotene; Solanum lycopersicum; mutagenesis
TL;DR:
Genetic and metabolic analyses showed that new mutants with enhanced and deficient carotenoid content in a single genetic background of tomato cv.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Effect of 4 weeks of high-intensity interval training on exercise performance and markers of inflammation and oxidative stress
FASEB Journal, 31.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Health modifying regions in the oat (Avena sativa) genome responsible for beneficial effects on immune and gastrointestinal health
FASEB Journal, 31.
Source: NC State University Libraries
Added: August 6, 2018
2017 article
In vitro Hypoallergenicity of Peanut Protein-Blueberry Polyphenol Aggregate Particles
Plundrich, N., Bansode, R., Williams, L., & Lila, M. A. (2017, February). JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol. 139, pp. AB139–AB139.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
In vitro hypoallergenic potential of peanut protein-polyphenol aggregate particles
FASEB Journal, 31.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Influence of Ingesting a Flavonoid-Rich Supplement on the Metabolome and Concentration of Urine Phenolics in Overweight/Obese Women
JOURNAL OF PROTEOME RESEARCH, 16(8), 2924–2935.
Contributors: D. Nieman *, S. Ramamoorthy *, C. Kay n , C. Goodman*, C. Capps*, Z. Shue*, N. Heyl*, M. Grace n , n
author keywords: dietary supplement; metabolomics; polyphenol; obesity
MeSH headings : Adolescent; Adult; Aged; Dietary Supplements; Female; Flavonoids / administration & dosage; Flavonoids / pharmacology; Humans; Intestinal Mucosa / metabolism; Metabolome / drug effects; Metabolomics / methods; Middle Aged; Obesity / metabolism; Obesity / urine; Overweight / metabolism; Overweight / urine; Phenols / urine; Young Adult
TL;DR:
It was shown that 12 weeks ingestion of a mixed flavonoid nutrient supplement was associated with a corresponding increase in urine total phenolics and gut-derived phenolic metabolites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Inter- and intra-seasonal changes in anthocyanin accumulation and global metabolite profiling of six blueberry genotypes
JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 59, 105–110.
Contributors: M. Timmers n, M. Grace n , G. Yousef n & n
author keywords: Anthocyanin; HPLC; PCA; Blueberry; Metabolite profile; Genotype and seasonal variations; Food analysis; Food composition
TL;DR:
Genotypes were easily distinguished from one another across each harvest season, indicating that each genotype had distinctly different metabolite profile, whereas each of the rabbiteye genotypes overlapped on the scores plot, indicating commonalities in metabolite profiles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms
JOURNAL OF ETHNOPHARMACOLOGY, 206, 408–425.
MeSH headings : Humans; Indians, North American; Medicine, Traditional; Parkinson Disease / drug therapy; Parkinson Disease / physiopathology; Plants, Medicinal / chemistry
TL;DR:
Analysis of contemporary herbal medicinal practices used by members of the Lumbee tribe to treat PD-related symptoms highlights potential therapeutic benefits of botanical extracts used in traditional Lumbee medicine, and provides insight into mechanisms by which an elderflower extract could suppress neurotoxicity elicited by environmental and genetic PD- related insults.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Metabolic Effects of Berries with Structurally Diverse Anthocyanins
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(2).
Contributors: J. Overall n , S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n , D. Esposito n , n , S. Komarnytsky n
author keywords: berry; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Anthocyanins / metabolism; Body Composition; Body Weight; Chromatography, High Pressure Liquid; Dietary Supplements; Feces / chemistry; Fruit / metabolism; Gastrointestinal Microbiome; Glucose / metabolism; Humans; Insulin Resistance; Mice; Molecular Structure; Oxygen Consumption
TL;DR:
Examination of effects of six berries with structurally diverse anthocyanin profiles on development of metabolic risk factors in the C57BL/6 mouse model of polygenic obesity showed a prominent discrepancy between biological activities of delphinidin/malvidin-versus cyanidin-type anthocianins that could be explained by differences in their structure and metabolism in the gut.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Polyphenol-enriched berry extracts naturally modulate reactive proteins in model foods
Food & Function, 8(12), 4760–4767.
MeSH headings : Animals; Dendritic Cells / immunology; Food Hypersensitivity / prevention & control; Fruit / chemistry; Fruit and Vegetable Juices / analysis; Functional Food / analysis; Humans; Macrophages / immunology; Ovalbumin / chemistry; Ovalbumin / immunology; Plant Extracts / chemistry; Polyphenols / chemistry; Swine; Tumor Necrosis Factor-alpha / immunology; Whey Proteins / chemistry; Whey Proteins / immunology
TL;DR:
The reactive allergenic epitopes of certain proteins were effectively blunted by binding with polyphenols, attenuating the allergenicity of the food proteins, allowing for the potential creation of hypoallergenic protein-berry polyphenol enriched foods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 17, 2020
2017 journal article
Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities
Chinese Journal of Natural Medicines, 15(11), 816–824.
Contributors: J. Xiong n , M. Grace n , D. Esposito n , S. Komarnytsky n , F. Wang * & n
author keywords: Acacia mearnsii; Proanthocyanidins; Anti-inflammatory; alpha-Amylase; alpha-Glucosidase
MeSH headings : Acacia / chemistry; Animals; Anti-Inflammatory Agents / isolation & purification; Anti-Inflammatory Agents / pharmacology; Carbohydrate Metabolism / drug effects; Glycoside Hydrolase Inhibitors / pharmacology; Inflammation / metabolism; Interleukin-1beta / metabolism; Lipopolysaccharides; Macrophages / drug effects; Mice; Nitric Oxide / metabolism; Nitric Oxide Synthase Type II / metabolism; Plant Bark / chemistry; Plant Extracts / chemistry; Plant Extracts / pharmacology; Polyphenols / isolation & purification; Polyphenols / pharmacology; Proanthocyanidins / pharmacology; RAW 264.7 Cells; alpha-Amylases / antagonists & inhibitors; alpha-Glucosidases / metabolism
TL;DR:
Polyphenols isolated from Acacia mearnsii bark crude extract and fractions obtained by high-speed counter-current chromatography and evaluated their anti-inflammatory and carbolytic enzymes (α-glucosidase and α-amylase) inhibitory activities showed significant activities against reactive oxygen species, nitric oxide production, and expression of pro-inflammatory genes interleukin-1β.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2017 journal article
Protein-bound Vaccinium fruit polyphenols decrease IgE binding to peanut allergens and RBL-2H3 mast cell degranulation in vitro
FOOD & FUNCTION, 8(4), 1611–1621.
MeSH headings : Allergens / immunology; Arachis / immunology; Cell Degranulation / drug effects; Fruit / chemistry; Humans; Immunoglobulin E / immunology; Mast Cells / drug effects; Mast Cells / immunology; Mast Cells / physiology; Peanut Hypersensitivity / drug therapy; Peanut Hypersensitivity / immunology; Plant Extracts / pharmacology; Plant Proteins / immunology; Polyphenols / pharmacology; Vaccinium / chemistry
TL;DR:
The modification of peanut proteins with cranberry or blueberry polyphenols led to the formation of peanut protein-polyphenol complexes with significantly reduced allergenic potential.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Protein-bound polyphenols create “ghost” band artifacts during chemiluminescence-based antigen detection
F1000Research, 6, 254.
TL;DR:
This study suggests that caution should be taken when evaluating polyphenol-bound proteins by enhanced chemiluminescence Western blotting using horseradish peroxidase and demonstrates that protein-bound polyphenols can be a source of “ghost” band artifacts on Western blots.
(via Semantic Scholar)
Source: ORCID
Added: February 17, 2020
2017 journal article
Protein-bound polyphenols create “ghost” band artifacts during chemiluminescence-based antigen detection [version 1; referees: awaiting peer review]
F1000Research, 6(254), 254.
Source: ORCID
Added: February 17, 2020
2017 journal article
Protein-polyphenol particles for delivering structural and health functionality
FOOD HYDROCOLLOIDS, 72, 163–173.
author keywords: Protein; Polyphenols; Colloidal aggregates; Health, and Structural Functionality
TL;DR:
The overall goal should be a rational design of protein-polyphenol particles to ensure a positive contribution to food quality, protein nutrition, and delivery of a health-relevant dose of polyphenols to the gastrointestinal tract.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Wild blueberry polyphenol-protein food ingredients produced by three drying methods: Comparative physico-chemical properties, phytochemical content, and stability during storage
FOOD CHEMISTRY, 235, 76–85.
Contributors: R. Correia n, M. Grace n , D. Esposito n & n
author keywords: Soy protein isolate; By-products; Spray drying; Phenolics; Shelf life
MeSH headings : Anthocyanins / analysis; Antioxidants; Blueberry Plants / chemistry; Desiccation / methods; Food Handling / methods; Freeze Drying; Phytochemicals; Polyphenols
TL;DR:
Overall, spray drying the blueberry extracts complexed with protein proved to be an environment-friendly strategy to produce stable functional ingredients with multiple applications for the food industry.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
alpha-Amylase and alpha-Glucosidase inhibitory activities of phenolic extracts from Eucalyptus grandis x E-urophylla Bark
Journal of Chemistry.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
α-Amylase and α-Glucosidase Inhibitory Activities of Phenolic Extracts from Eucalyptus grandis × E. urophylla Bark
Journal of Chemistry, 2017, 1–7.
Contributors: P. Jiang *, J. Xiong* , F. Wang *, M. Grace n , n & R. Xu *
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 12, 2019
2016 journal article
A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice
The Journal of Nutritional Biochemistry, 31, 150–165.
Contributors: B. Collins*, J. Hoffman *, K. Martinez *, M. Grace* , * , C. Cockrell *, A. Nadimpalli*, E. Chang *
author keywords: Grapes; Obesity; Steatosis; Inflammation; Intestines; Microbiota
MeSH headings : Adiposity / drug effects; Animals; Biomarkers / metabolism; Diet, High-Fat; Gastrointestinal Microbiome / drug effects; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Polyphenols / pharmacology; Vitis / chemistry
TL;DR:
Data demonstrate that the polyphenol-rich, EP fraction from table grapes attenuated many of the adverse health consequences associated with consuming an HF diet.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019
2016 journal article
Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts
Food Chemistry, 210, 85–95.
Contributors: M. Grace n , D. Esposito n , M. Timmers n, J. Xiong n , G. Yousef n, S. Komarnytsky n , n
author keywords: Anacardic acids; Triterpene acids; Carotenoids; Tocopherols; Polyphenols; Anti-inflammatory
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / isolation & purification; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / isolation & purification; Antioxidants / pharmacology; Cell Line; Dose-Response Relationship, Drug; Macrophages / drug effects; Macrophages / metabolism; Mice; Pistacia; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Extracts / pharmacology; Reactive Oxygen Species / antagonists & inhibitors; Reactive Oxygen Species / metabolism
TL;DR:
The P extract significantly decreased the non-mitochondrial oxidative burst associated with inflammatory response in macrophages and significantly inhibited the release of nitric oxide and reactive oxygen species in lipopolysaccharide-stimulated RAW 264.7 macrophage cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2016 journal article
Formation of whey protein–polyphenol meso-structures as a natural means of creating functional particles
Food & Function, 7(3), 1306–1318.
MeSH headings : Fruit / chemistry; Hydrogen-Ion Concentration; Particle Size; Plant Extracts / chemistry; Polyphenols / chemistry; Ribes / chemistry; Vaccinium macrocarpon / chemistry; Vitis / chemistry; Whey Proteins / chemistry
TL;DR:
Particles improved foam stability, and the anti-inflammatory properties of entrapped polyphenols were maintained in the particles, suggesting highly functional protein-polyphenol particles can be designed to stabilize food structures and simultaneously deliver polyphenol associated with health benefits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018
2016 article
Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015
Blumberg, J. B., Basu, A., Krueger, C. G., Lila, M. A., Neto, C. C., Novotny, J. A., … Toner, C. D. (2016, July). ADVANCES IN NUTRITION, Vol. 7, pp. 759S–770S.
author keywords: cranberry; proanthocyanidins; microbiome; cardiometabolic; antimicrobial
MeSH headings : Animals; Anti-Infective Agents; Biofilms; Diet; Fruit / chemistry; Gastrointestinal Microbiome / physiology; Health Promotion; Heart Diseases / prevention & control; Humans; Inflammation; Lipids / blood; Metabolic Diseases / prevention & control; Oxidative Stress; Phytochemicals / administration & dosage; Phytochemicals / analysis; Plant Extracts / pharmacology; Proanthocyanidins; Risk Factors; Vaccinium macrocarpon / chemistry
TL;DR:
A limited but growing body of evidence from randomized clinical trials reveals favorable effects of cranberry consumption on measures of cardiometabolic health, including serum lipid profiles, blood pressure, endothelial function, glucoregulation, and a variety of biomarkers of inflammation and oxidative stress.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Impact of a new postharvest disinfection method based on peracetic acid fogging on the phenolic profile of strawberries
POSTHARVEST BIOLOGY AND TECHNOLOGY, 117, 197–205.
Contributors: F. Velde *, M. Grace n , M. Pirovani * & n
author keywords: Nebulization; Anthocyanins; Proanthocyanidins; Hydroxycinnamic acid derivatives; Ellagitannins
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
In vitro lipolytic, antioxidant and anti-inflammatory activities of roasted pistachio kernel and skin constituents
Food & Function, 7(10), 4285–4298.
Contributors: M. Grace n , D. Esposito n , M. Timmers n, J. Xiong n , G. Yousef n, S. Komarnytsky n , n
MeSH headings : Animals; Antioxidants; Cell Survival / drug effects; Cooking; Macrophages / drug effects; Macrophages / metabolism; Mice; Phytochemicals; Pistacia / chemistry; RAW 264.7 Cells; Reactive Oxygen Species; Respiratory Burst; Seeds / chemistry
TL;DR:
The SNP had the strongest effect in decreasing non-mitochondrial oxidative burst associated with inflammatory response in macrophages, and was the most potent to inhibit the expression of COX2.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2016 journal article
One-step isolation of carnosic acid and carnosol from rosemary by centrifugal partition chromatography
JOURNAL OF SEPARATION SCIENCE, 40(5), 1057–1062.
author keywords: carnosic acid; carnosol; centrifugal partition chromatography; Rosmarinus officinalis
MeSH headings : Abietanes / isolation & purification; Chromatography; Plant Extracts / chemistry; Rosmarinus / chemistry
TL;DR:
Carnosic acid and carnosol are the main bioactive components responsible for the significant antioxidant activity of Rosmarinus officinalis and were identified by mass spectrometry, tandem mass spectromaetry, and comparison with authentic standards.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
Phytochemical characterization and anti-inflammatory properties of Acacia mearnsii leaves
Natural Product Communications, 11(5), 649–653.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Quantitative comparison of phytochemical profile, antioxidant, and anti-inflammatory properties of blackberry fruits adapted to Argentina
JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 47, 82–91.
Contributors: F. Velde *, M. Grace n , D. Esposito n , M. Pirovani * & n
author keywords: Bubo fruticosus; Polyphenols content; Vitamin C; Cyanidin-3-O-glucoside; Proanthocyanidins; Reactive oxygen species; Cyclooxygenase-2; Interleukin-6; Food analysis; Food composition
TL;DR:
The potential of blackberries cultivars ‘Black Satin’ and ‘Jumbo’ to contribute to a healthy diet, based on their higher polyphenol content, providing higher antioxidant and anti-inflammatory properties is suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 review
Unraveling anthocyanin bioavailability for human health
[Review of ]. Annual review of food science and technology, vol 7, 7, 375–393.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Alaskan seaweeds lower inflammation in RAW 264.7 macrophages and decrease lipid accumulation in 3T3-L1 adipocytes
JOURNAL OF FUNCTIONAL FOODS, 15, 396–407.
Contributors: J. Kellogg n, D. Esposito n , M. Grace n , S. Komarnytsky n & n
author keywords: Seaweed; Phlorotannin; Monoglycosyldiacylglycerol; Inflammation; Insulin resistance; Fucus distichus
TL;DR:
Overall, the Alaskan seaweed F. distichus inhibited proinflammatory responses and improved lipid metabolism, suggesting the potential for seaweed phytochemicals to attenuate inflammatory diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Black Currant Anthocyanins Attenuate Weight Gain and Improve Glucose Metabolism in Diet-Induced Obese Mice with Intact, but Not Disrupted, Gut Microbiome
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(27), 6172–6180.
Contributors: D. Esposito n , T. Damsud n, M. Wilson n, M. Grace n , R. Strauch n, X. Li n , n , S. Komarnytsky n
author keywords: gastrointestinal tract; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animals; Anthocyanins / administration & dosage; Anthocyanins / chemistry; Fruit / chemistry; Gastrointestinal Microbiome / drug effects; Glucose / metabolism; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity / drug therapy; Obesity / metabolism; Obesity / microbiology; Obesity / physiopathology; Plant Extracts / administration & dosage; Plant Extracts / chemistry; Ribes / chemistry; Weight Gain / drug effects
TL;DR:
The data clearly demonstrate that gut microbiome and the type of the anthocyanin aglycone moiety can alter the protective effect of Anthocyanins against obesity and associated insulin resistance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Characterization of Phenolic Compounds and Antioxidant and Antiinflammatory Activities from Mamuyo (Styrax ramirezii Greenm.) Fruit
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(48), 10459–10465.
Contributors: M. Timmers n, J. Guerrero-Medina n, D. Esposito n , M. Grace n , O. Paredes-López *, P. García-Saucedo*, n
author keywords: LC-TOF-MS; Styrax ramirezii; antioxidant activity; anti-inflammatory activity; norneolignan
MeSH headings : Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / pharmacology; Cyclooxygenase 2 / immunology; Fruit / chemistry; Humans; Interleukin-1beta / immunology; Nitric Oxide / immunology; Nitric Oxide Synthase Type II / immunology; Nitric Oxide Synthase Type II / metabolism; Phenols / chemistry; Phenols / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology; Reactive Oxygen Species / metabolism; Styrax / chemistry
TL;DR:
Egonol potently inhibited the production of NO and also significantly reduced the release of ROS, suggesting the potential of S. ramirezii Greenm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Community-Based Research as a Mechanism to Reduce Environmental Health Disparities in American Indian and Alaska Native Communities
International Journal of Environmental Research and Public Health, 12(4), 4076–4100.
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2015 journal article
Method to harness bioactive secondary metabolites from intact Quinoa seeds with implications for chronic disease prevention
Planta Medica, 81(11).
Sources: Crossref, NC State University Libraries
Added: February 21, 2020
2015 journal article
New functionally-enhanced soy proteins as food ingredients with anti-viral activity
VirusDisease, 26(3), 123–132.
TL;DR:
Anti-viral properties of both cranberry juice-en enriched and cranberry pomace polyphenol-enriched soy protein isolate (CB-SPI and CBP- SPI) were tested against influenza viruses in vitro and in ovo and suggest CB-SPi and CBPs may have preventative and therapeutic potential against viral infections that cause diseases of the respiratory and gastro-intestinal tract.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2015 journal article
Novel value-added uses for sweet potato juice and flour in polyphenol- and protein-enriched functional food ingredients
FOOD SCIENCE & NUTRITION, 3(5), 415–424.
Contributors: M. Grace n , A. Truong n, V. Truong n, I. Raskin * & n
author keywords: Anti-inflammatory; antioxidant; berries; polyphenols; stability; sweet potato
TL;DR:
Sensory evaluation of the ingredient matrices suggested potential uses for a wide range of functional food products, and anti-inflammatory and antioxidant fruit polyphenols with sweet potato functional constituents correlated well with total phenolic content.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
RNA-Seq analysis and annotation of a draft blueberry genome assembly identifies candidate genes involved in fruit ripening, biosynthesis of bioactive compounds, and stage-specific alternative splicing
Gigascience, 4.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Stability and immunogenicity of hypoallergenic peanut protein-polyphenol complexes during in vitro pepsin digestion
FOOD & FUNCTION, 6(7), 2145–2154.
MeSH headings : Antigens, Plant / chemistry; Antigens, Plant / immunology; Arachis / chemistry; Arachis / immunology; Digestion; Pepsin A / chemistry; Plant Proteins / chemistry; Plant Proteins / immunology; Polyphenols / chemistry; Polyphenols / immunology
TL;DR:
It is suggested that peanut protein-polyphenol complexes may be less immunoreactive passing through the digestive tract in vivo, contributing to their attenuated allergenicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 article
A need for a transdisciplinary environment: the Plant Pathways Elucidation Project
Reid, R. W., Brouwer, C. R., Jackson, E. W., & Lila, M. A. (2014, August). TRENDS IN PLANT SCIENCE, Vol. 19, pp. 485–487.
MeSH headings : Humans; Industry; Interdisciplinary Communication; Knowledge Bases; Metabolic Networks and Pathways; Plants / metabolism; Universities
TL;DR:
The Plant Pathways Elucidation Project (P2EP) is a multi-institutional project that utilizes cutting-edge genomics research and related disciplines to provide greater understanding of the relation between plant-pathway products and human health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Ajuga turkestanica increases Notch and Wnt signaling in aged skeletal muscle
European Review for Medical and Pharmacological Sciences, 18(17), 2584–2592.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Anthocyanin profiling of wild maqui berries (Aristotelia chilensis [Mol.] Stuntz) from different geographical regions in Chile
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 94(13), 2639–2648.
Contributors: C. Fredes *, G. Yousef n, P. Robert *, M. Grace n , n , M. Gómez*, M. Gebauer*, G. Montenegro *
author keywords: delphinidin-3; 5-diglucoside; delphinidin-3-glucoside; genetic diversity; maqui genotypes; ISSR-PCR
MeSH headings : Altitude; Anthocyanins / analysis; Anthocyanins / metabolism; Antioxidants / analysis; Antioxidants / metabolism; Chile; Chromatography, High Pressure Liquid; Climate; Elaeocarpaceae / chemistry; Elaeocarpaceae / genetics; Elaeocarpaceae / growth & development; Elaeocarpaceae / metabolism; Fruit / chemistry; Fruit / genetics; Fruit / growth & development; Fruit / metabolism; Genetic Markers; Genetic Variation; Limit of Detection; Phenols / analysis; Phenols / metabolism; Phylogeny; Spatio-Temporal Analysis; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Wilderness
TL;DR:
Three maqui genotypes exhibited significantly higher anthocyanin content than the others, as measured by pH differential method and high-performance liquid chromatography-mass spectrometry and significant genetic diversity was noted within each ecological population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Bioactive Capacity, Sensory Properties, and Nutritional Analysis of a Shelf Stable Protein-rich Functional Ingredient with Concentrated Fruit and Vegetable Phytoactives
PLANT FOODS FOR HUMAN NUTRITION, 69(4), 372–378.
Contributors: M. Grace n , G. Yousef n, D. Esposito n , I. Raskin * & n
author keywords: Muscadine; Kale; Protein isolate; Inflammatory biomarkers
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Anti-Inflammatory Agents / therapeutic use; Brassica / chemistry; Cannabis; Carotenoids / pharmacology; Carotenoids / therapeutic use; Chemokine CCL2 / metabolism; Diet; Dietary Proteins / analysis; Fruit / chemistry; Functional Food / analysis; Glucosinolates / pharmacokinetics; Glucosinolates / pharmacology; Humans; Inflammation / drug therapy; Inflammation / metabolism; Interleukin-6 / metabolism; Mice; Nutritive Value; Plant Preparations / pharmacology; Plant Preparations / therapeutic use; Polyphenols / pharmacology; Polyphenols / therapeutic use; Soybean Proteins; Taste; Vegetables / chemistry; Vitis / chemistry
TL;DR:
Proximate analyses determined that fortification of the soy protein isolate with muscadine or kale bioactives resulted in elevated dietary fibers, total carbohydrates, and free sugars, but did not increase calories/100 g dry matrix compared to unfortified SPI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 conference paper
Capitalizing on the health benefits of berryfruit: Science versus the marketplace
Ii international symposium on biotechnology of fruit species, 1048, 123–128.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2014 journal article
Compounds leached from quinoa seeds inhibit matrix metalloproteinase activity and intracellular reactive oxygen species
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, 37(2), 212–221.
author keywords: ageing; cell culture; chemical analysis; oxidative damage; phytochemistry; phytoecdysteroid
MeSH headings : Cells, Cultured; Chenopodium quinoa / embryology; Chromatography, Liquid; Humans; Mass Spectrometry; Matrix Metalloproteinase 1 / drug effects; Matrix Metalloproteinase 1 / genetics; Monophenol Monooxygenase / antagonists & inhibitors; Protease Inhibitors / pharmacology; Reactive Oxygen Species / metabolism; Seeds / chemistry
TL;DR:
This work aimed to determine the effect of QL and its chemically distinct fractions on five biochemical endpoints relevant to skin care applications: cell viability, matrix metalloproteinase (MMP) mRNA expression, MMP enzymatic activity, tyrosinase enzymatics activity and intracellular reactive oxygen species (ROS) production.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Concentrating Immunoprotective Phytoactive Compounds from Fruits and Vegetables into Shelf-stable Protein-rich Ingredients
PLANT FOODS FOR HUMAN NUTRITION, 69(4), 317–324.
Contributors: G. Yousef n, M. Grace n , J. Medina n, S. Neff n, I. Guzman n, A. Brown n, I. Raskin *, n
author keywords: Muscadine; Kale; Polyphenolics; Carotenoids; Glucosinolates; Protein isolate
MeSH headings : Brassica / chemistry; Carotenoids / analysis; Diet; Dietary Proteins; Food Handling; Fruit / chemistry; Functional Food; Glucosinolates / analysis; Humans; Immunologic Factors; Plant Extracts / chemistry; Polyphenols / analysis; Vegetables / chemistry; Vitis / chemistry
TL;DR:
Neither total phenolics nor glucosinolates were significantly diminished even after long term storage at 4, 20, or 37 °C, whereas carotenoids degraded over time, particularly at higher temperatures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Cytotoxic Effects of Ellagitannins Isolated from Walnuts in Human Cancer Cells
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 66(8), 1304–1314.
Contributors: V. Le*, D. Esposito n , M. Grace n , D. Ha*, A. Pham*, A. Bortolazzo*, Z. Bevens*, J. Kim *
MeSH headings : 3T3 Cells; Animals; Apoptosis / drug effects; Cell Line, Tumor; Cyclin B1 / metabolism; Cytochromes c / metabolism; Diet; HeLa Cells; Humans; Hydrogen-Ion Concentration; Hydrolyzable Tannins / pharmacology; Juglans / chemistry; MCF-7 Cells; Mice; Mice, Nude; Mitochondria / drug effects; Nuts / chemistry; Plant Extracts / pharmacology
TL;DR:
The results suggest impairment of mitochondrial function and apoptosis as relevant mechanism of anticancer effects of the walnut extract as well as antimitogenic effects of walnuts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Efficient preparative isolation and identification of walnut bioactive components using high-speed counter-current chromatography and LC-ESI-IT-TOF-MS
FOOD CHEMISTRY, 158, 229–238.
Contributors: M. Grace n , C. Warlick n, S. Neff n & n
author keywords: Walnut; Jug Ions regia; Ellagitannins; High-speed counter-current; chromatography; ESI-MS/MS
MeSH headings : Chromatography, High Pressure Liquid / methods; Countercurrent Distribution / methods; Juglans / chemistry; Tandem Mass Spectrometry / methods
TL;DR:
These results provided a foundation for in depth characterisation of walnut compounds and offered an efficient strategy for isolation of potentially health-relevant phytochemicals from walnuts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Inhibitory Effects of Wild Blueberry Anthocyanins and Other Flavonoids on Biomarkers of Acute and Chronic Inflammation in Vitro
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(29), 7022–7028.
Contributors: D. Esposito n , A. Chen n, M. Grace n , S. Komarnytsky n & n
author keywords: Vaccinium angustifolium; lowbush blueberry; polyphenols; proanthocyanidins; chlorogenic acid
MeSH headings : Acute Disease; Animals; Anthocyanins / pharmacology; Base Sequence; Biomarkers / metabolism; Blueberry Plants / chemistry; Cell Line; Chromatography, High Pressure Liquid; Chronic Disease; DNA Primers; In Vitro Techniques; Inflammation / metabolism; Macrophages / drug effects; Macrophages / metabolism; Mice; Polymerase Chain Reaction
TL;DR:
Among major polyphenols found in the wild blueberries, malvidin-3-glucoside was significantly more effective than epicatechin or chlorogenic acid in reducing the expression of pro-inflammatory genes in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease
Brain Research, 1555, 60–77.
Contributors: K. Strathearn*, G. Yousef n, M. Grace n , S. Roy*, M. Tambe *, M. Ferruzzi*, Q. Wu*, J. Simon *, n , J. Rochet *
author keywords: Anthocyanin; Microglial activation; Mitochondria; Parkinson's disease; Proanthocyanidin; Rotenone
MeSH headings : Animals; Anthocyanins / therapeutic use; Cells, Cultured; Dopaminergic Neurons / drug effects; Dopaminergic Neurons / metabolism; Mice; Microglia / drug effects; Mitochondria / drug effects; Mitochondria / metabolism; Neuroprotective Agents / therapeutic use; Parkinson Disease / drug therapy; Parkinson Disease / metabolism; Phytotherapy; Plant Extracts / therapeutic use; Proanthocyanidins / therapeutic use; Rotenone / toxicity; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
It is suggested that anthocyanin- and proanthocyanidin-rich botanical extracts may alleviate neurodegeneration in PD via enhancement of mitochondrial function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2014 journal article
Novel Strategy To Create Hypoallergenic Peanut Protein-Polyphenol Edible Matrices for Oral Immunotherapy
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(29), 7010–7021.
Contributors: N. Plundrich n, M. Kulis*, B. White*, M. Grace n , R. Guo *, A. Burks *, J. Davis*, n
author keywords: basophil; cranberry; mouse model; peanut allergy; polyphenols
MeSH headings : Administration, Oral; Arachis / immunology; Arachis / metabolism; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Humans; Immunotherapy; Peanut Hypersensitivity / prevention & control; Plant Proteins / administration & dosage; Plant Proteins / immunology; Polyphenols / administration & dosage; Polyphenols / immunology; Spectroscopy, Fourier Transform Infrared
TL;DR:
Polyphenol fortification of peanut flour resulted in a hypoallergenic matrix with reduced IgE binding and degranulation capacity, likely due to changes in protein secondary structure or masking of epitopes, suggesting potential applications for oral immunotherapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Novel strategies for capturing health-protective mango phytochemicals in shelf stable food matrices
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 66(2), 175–185.
Contributors: I. Guzman n, M. Grace n , G. Yousef n, I. Raskin * & n
author keywords: Carotenoids; fortified foods; polyphenols; protein-rich flour; vitamin A
MeSH headings : Africa; Arachis; Carbohydrates / analysis; Carotenoids / administration & dosage; Carotenoids / analysis; Diet; Dietary Proteins; Flour / analysis; Food Handling / methods; Food Preservation; Fruit / chemistry; Health; Helianthus; Humans; Malnutrition / prevention & control; Mangifera / chemistry; Phytochemicals / analysis; Plant Oils; Polyphenols / administration & dosage; Polyphenols / analysis; Rural Population; Soybeans; Sunflower Oil
TL;DR:
Cost-effective methods for concentration and stabilization of otherwise perishable mango fruit phytoactives into shelf stable high protein ingredients were developed to combat stunting (malnutrition) in rural Africa and capture the benefits of Otherwise perishable seasonal resources by complexing healthful proteins together with phy toactive compounds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Phlorotannins from Alaskan Seaweed Inhibit Carbolytic Enzyme Activity
MARINE DRUGS, 12(10), 5277–5294.
Contributors: J. Kellogg n, M. Grace n & n
author keywords: Alaska; seaweed; diabetes; glucosidase; hyperglycemia; amylase; type 2 diabetes mellitus; phlorotannin; polyphenol; ethnopharmacology
MeSH headings : Animals; Biological Factors / metabolism; Biological Factors / pharmacology; Carbohydrates; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Fucus / metabolism; Kinetics; Saccharomyces cerevisiae / metabolism; Seaweed / metabolism; Swine / metabolism; Tannins / metabolism; Tannins / pharmacology; alpha-Amylases / antagonists & inhibitors; alpha-Glucosidases / metabolism
TL;DR:
It is suggested that coastal Alaskan seaweeds are sources of α-glucosidase and α-amylase inhibitory phlorotannins, and thus have potential to limit the release of sugar from carbohydrates and thus alleviate postprandial hyperglycemia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Quinoa seeds leach phytoecdysteroids and other compounds with anti-diabetic properties
FOOD CHEMISTRY, 163, 178–185.
Contributors: B. Graf *, A. Poulev *, P. Kuhn *, M. Grace n , n & I. Raskin *
author keywords: Ecdysterone; Flavonoids; Metabolic syndrome; Nutraceutical; Phytoecdysteroids
MeSH headings : Animals; Chenopodium quinoa / chemistry; Chromatography, Liquid; Ecdysterone / isolation & purification; Ecdysterone / pharmacology; Hypoglycemic Agents / isolation & purification; Male; Mice; Mice, Inbred C57BL; Seeds / chemistry
TL;DR:
Leaching effectively releases and concentrates bioactive phytochemicals from quinoa seeds, providing an efficient means to produce a food-grade mixture that may be useful for anti-diabetic applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro
PHYTOCHEMISTRY, 103, 114–122.
author keywords: Moringa oleifera; Moringaceae Chronic inflammation; Isothiocyanates; 4-[(alpha-L-rhamnosyloxy) benzyl]isothiocyanate; 4-[(4'-O-acetyl-alpha-L-rhamnosyloxy) benzyl]isothiocyanate
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Cell Line; Interleukin-1beta / metabolism; Isothiocyanates / chemistry; Isothiocyanates / pharmacology; Macrophages / drug effects; Macrophages / metabolism; Mice; Moringa oleifera; Nitric Oxide / metabolism; Nitric Oxide Synthase Type II / metabolism; Plant Extracts / chemistry; Plant Extracts / pharmacology; Plant Leaves / chemistry; Water / chemistry
TL;DR:
A potential for stable and concentrated moringa isothiocyanates, delivered in MC as a food-grade product, to alleviate low-grade inflammation associated with chronic diseases is suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 article
Stressed for Success: How the Berry's Wild Origins Result in Multifaceted Health Protections
X INTERNATIONAL SYMPOSIUM ON VACCINIUM AND OTHER SUPERFRUITS, Vol. 1017, pp. 23–43.
author keywords: elicitation; anthocyanins; proanthocyanidins; inflammation; metabolic syndrome
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
The Protective Effects of a Polyphenol-Enriched Protein Powder on Exercise-Induced Susceptibility to Virus Infection
PHYTOTHERAPY RESEARCH, 28(12), 1829–1836.
author keywords: virus infection; polyphenols; green tea; blueberry extract
MeSH headings : Adult; Athletes; Dietary Supplements; Disease Susceptibility / physiopathology; Exercise; Female; HeLa Cells; Humans; Immune Tolerance / drug effects; Male; Middle Aged; Polyphenols / pharmacology; Running; Soybean Proteins; Tea; Vaccinium; Vesiculovirus; Virus Diseases / prevention & control; Young Adult
TL;DR:
It is indicated that polyphenol complexes containing blueberry and green tea have the potential to protect athletes from virus infections following rigorous exercise.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Anthocyanins and proanthocyanidins from blueberry-blackberry fermented beverages inhibit markers of inflammation in macrophages and carbohydrate-utilizing enzymes in vitro
MOLECULAR NUTRITION & FOOD RESEARCH, 57(7), 1182–1197.
author keywords: Anthocyanin; Berry; Diabetes; Hydrolysable tannins; Inflammation; Proanthocyanidin
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Antioxidants / pharmacology; Beverages; Blueberry Plants / chemistry; Cell Line, Tumor; Cell Proliferation / drug effects; Fermentation; Fruit / chemistry; Glucosides / analysis; Inflammation / prevention & control; Lipopolysaccharides / adverse effects; Macrophages / drug effects; Macrophages / metabolism; Mice; NF-kappa B / genetics; NF-kappa B / metabolism; Plant Extracts / pharmacology; Polyphenols / pharmacology; Proanthocyanidins / pharmacology; Wine / analysis; alpha-Amylases / metabolism; alpha-Glucosidases / metabolism
TL;DR:
ANCs demonstrated that delphinidin-3-arabinoside effectively inactivated dipeptidyl peptidase-IV by binding with the lowest interaction energy (-3228 kcal/mol).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Berry and citrus phenolic compounds inhibit dipeptidyl peptidase IV: Implications in diabetes management
Evidence-Based Complementary and Alternative Medicine.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Bioactive polyphenols from muscadine grape and blackcurrant stably concentrated onto protein-rich matrices for topical applications
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, 35(4), 394–401.
Contributors: N. Plundrich n, M. Grace n , I. Raskin * & M. Ann Lila n
author keywords: antimicrobial; blackcurrant; muscadine grape; polyphenols; topical applications; tyrosinase
MeSH headings : Polyphenols / administration & dosage; Polyphenols / pharmacology; Proteins / drug effects; Ribes / chemistry; Vitis / chemistry
TL;DR:
Natural botanical agents that are antimicrobial, or that modulate skin hyperpigmentation via tyrosinase inhibition, are increasingly sought in the cosmetic industry.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Biosynthesis of highly enriched C-13-lycopene for human metabolic studies using repeated batch tomato cell culturing with C-13-glucose
FOOD CHEMISTRY, 139(1-4), 631–639.
author keywords: Carotenoids; Tracers; Lycopene; Tomato; Nutrition; Plant cell culture
MeSH headings : Biological Availability; Carbon Isotopes / metabolism; Carotenoids / biosynthesis; Cells, Cultured; Glucose / chemistry; Glucose / metabolism; Humans; Isotope Labeling; Lycopene; Solanum lycopersicum / chemistry; Solanum lycopersicum / metabolism
TL;DR:
An optimised acetone and hexane extraction led to a fourfold increase in lycopene recovery from cultures compared to a standard extraction and an optimised 9-day-long and 18- day-long labelling strategy developed based on glucose utilisation and lycopenes yields yielded (13)C-lycopene with 93% ( 13)C isotopic purity, and 55% of isotopomers were uniformly labelled.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Chemical and in Vitro Assessment of Alaskan Coastal Vegetation Antioxidant Capacity
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 61(46), 11025–11032.
author keywords: Alaska; seaweed; antioxidant; RAW 264.7 macrophages; radical oxygen species; phlorotannin; nitric oxide; total phenolic content
MeSH headings : Alaska; Animals; Antioxidants / analysis; Antioxidants / pharmacology; Cell Line; Cell Survival / drug effects; Fucus / chemistry; Mice; Phenols / chemistry; Phenols / pharmacology; Plant Extracts / analysis; Plant Extracts / pharmacology; Plantago / chemistry; Rhodophyta / chemistry; Seaweed / chemistry; Ulva / chemistry; Vegetables / chemistry
TL;DR:
The results support the potential of Alaskan coastal vegetation, especially the brown algae, as natural sources of antioxidants for preventing oxidative degeneration and maintaining human health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Comparative Analysis of Phenolic Content and Profile, Antioxidant Capacity, and Anti-inflammatory Bioactivity in Wild Alaskan and Commercial Vaccinium Berries
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(18), 4007–4017.
Contributors: M. Grace n , D. Esposito n , K. Dunlap * & n
author keywords: Vaccinium vitis-idaea; V. uliginosum; V. macrocarpon; V. angustifolium; phenolics; antioxidant; anti-inflammatory
MeSH headings : Alaska; Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / pharmacology; Chromatography, High Pressure Liquid; Fruit / chemistry; Macrophages / drug effects; Macrophages / immunology; Mass Spectrometry; Mice; Phenols / chemistry; Plant Extracts / chemistry; Plant Extracts / pharmacology; Vaccinium / chemistry
TL;DR:
A polyphenol-rich fraction from lowbush cranberry exhibited dose-dependent inhibition of LPS-elicited induction of IL-1β in RAW 2647 cells, indicative of strong anti-inflammatory activity, corroborate the historic use of wild Alaskan berries as medicinally important foods in Alaska Native communities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Concord Grape Pomace Polyphenols Cornplexed to Soy Protein Isolate Are Stable and Hypoglycemic in Diabetic Mice
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 61(47), 11428–11433.
author keywords: grape pomace; polyphenols; soy protein isolate; nutrition; hyperglycemia
MeSH headings : Animals; Blood Glucose; Chemical Fractionation / methods; Diabetes Mellitus, Experimental / drug therapy; Drug Stability; Hyperglycemia / drug therapy; Hyperglycemia / metabolism; Hypoglycemic Agents / pharmacology; Male; Mice; Mice, Inbred C57BL; Polyphenols / chemistry; Polyphenols / isolation & purification; Polyphenols / pharmacology; Proanthocyanidins / analysis; Soybean Proteins / chemistry; Soybean Proteins / pharmacology; Vitis / chemistry
TL;DR:
GP-SPI allows the capture of grape pomace polyphenols in a protein-rich food matrix and may be useful as a functional food ingredient for the management of blood glucose levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1)
FOOD CHEMISTRY, 142, 349–357.
Contributors: D. Ribnicky *, D. Roopchand *, A. Oren*, M. Grace n , A. Poulev *, n , R. Havenaar, I. Raskin *
author keywords: Blueberry; Anthocyanins; Bioavailability; Bioaccessibility; Gastrointestinal model; TIM-1; Soybean flour; Nutrition
MeSH headings : Anthocyanins / metabolism; Anthocyanins / pharmacokinetics; Biological Availability; Blueberry Plants / metabolism; Cell Line; Dietary Fats / analysis; Dietary Fats / metabolism; Digestion; Fruit / metabolism; Gastrointestinal Tract / metabolism; Humans; Intestinal Absorption; Models, Biological; Soybean Proteins / chemistry; Soybean Proteins / metabolism
TL;DR:
The TNO intestinal model (TIM-1) of the human upper gastrointestinal tract was used to compare intestinal absorption/bioaccessibility of blueberry anthocyanins under different digestive conditions, suggesting lipid-rich matrices selectively effect Anthocyanin bioaccessibility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Efficient Quantification of the Health-Relevant Anthocyanin and Phenolic Acid Profiles in Commercial Cultivars and Breeding Selections of Blueberries (Vaccinium spp.)
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 61(20), 4806–4815.
Contributors: G. Yousef n, A. Brown n, Y. Funakoshi n, F. Mbeunkui n, M. Grace n , J. Ballington n, A. Loraine *, n
author keywords: anthocyanins; chlorogenic acid; blueberry; HPLC-DAD-MS; Vaccinium spp.; freeze-drying; health benefits
MeSH headings : Anthocyanins / analysis; Blueberry Plants / chemistry; Breeding; Chromatography, High Pressure Liquid / methods; Food, Preserved / analysis; Frozen Foods / analysis; Fruit / chemistry; Genotype; Glucosides / analysis; Health Promotion; Humans; Hydroxybenzoates / analysis; Plant Extracts / chemistry; Species Specificity; Tandem Mass Spectrometry / methods
TL;DR:
An improved protocol was developed for the accurate, efficient, and rapid comparative screening for large blueberry sample sets and different genotypes frequently had comparable overall levels of total anthocyanins and phenolic acids, but differed dramatically in individual profiles of compounds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Food-compatible method for the efficient extraction and stabilization of cranberry pomace polyphenols
FOOD CHEMISTRY, 141(4), 3664–3669.
author keywords: Cranberry pomace; Polyphenols; Proanthocyanidins; Anthocyanins; Soy protein isolate
MeSH headings : Chemical Fractionation / methods; Fruit / chemistry; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Polyphenols / chemistry; Polyphenols / isolation & purification; Vaccinium macrocarpon / chemistry; Waste Products / analysis
TL;DR:
The extraction and stabilization of cranberry pomace polyphenols using SPI provides an innovative approach for utilizing pomACE in the development of novel food ingredients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Influence of a polyphenol-enriched protein powder on exercise-induced inflammation and oxidative stress in athletes: A randomized trial using a metabolomics approach
PLoS One, 8(8).
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Leishmanicidal activity of a daucane sesquiterpene isolated from Eryngium foetidum
PHARMACEUTICAL BIOLOGY, 52(3), 398–401.
Contributors: P. Rojas-Silva *, R. Graziose*, B. Vesely *, A. Poulev *, F. Mbeunkui n, M. Grace n , D. Kyle *, n , I. Raskin *
author keywords: Apiaceae; bioassay guided fractionation; cytotoxicity; leishmaniasis; LC-MS; NMR; sesquiterpenoids
MeSH headings : Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / isolation & purification; Antiprotozoal Agents / pharmacology; Cell Line; Chromatography / methods; Chromatography, High Pressure Liquid / methods; Eryngium / chemistry; Inhibitory Concentration 50; Leishmania / drug effects; Leishmania donovani / drug effects; Magnetic Resonance Spectroscopy / methods; Mass Spectrometry / methods; Myoblasts / drug effects; Myoblasts / metabolism; Myoblasts, Skeletal / drug effects; Myoblasts, Skeletal / metabolism; Plant Components, Aerial; Rats; Sesquiterpenes / administration & dosage; Sesquiterpenes / isolation & purification; Sesquiterpenes / pharmacology; Toxicity Tests
TL;DR:
The bioassay-guided fractionation with the leishmanicidal and cytotoxicity activities of two compounds isolated for the first time from an Eryngium species were presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Phytochemical changes in phenolics, anthocyanins, ascorbic acid, and carotenoids associated with sweetpotato storage and impacts on bioactive properties
FOOD CHEMISTRY, 145, 717–724.
Contributors: M. Grace n , G. Yousef n, S. Gustafson n, V. Truong n, G. Yencho n & n
author keywords: Sweetpotato; Phenolics; Carotenoids; Antioxidant activity; Storage; Postharvest
MeSH headings : Anthocyanins / analysis; Anthocyanins / isolation & purification; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / isolation & purification; Antioxidants / chemistry; Antioxidants / isolation & purification; Ascorbic Acid / analysis; Ascorbic Acid / isolation & purification; Carotenoids / analysis; Carotenoids / isolation & purification; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Food Storage; Genotype; Humans; Ipomoea batatas / chemistry; Ipomoea batatas / genetics; Ipomoea batatas / metabolism; Lipopolysaccharides; Phenols / analysis; Phenols / isolation & purification; Plant Extracts / chemistry; Reactive Oxygen Species / metabolism; Temperature; Time Factors
TL;DR:
Gradual changes in sweetpotato phytochemical content and antioxidant and anti-inflammatory capacity were noted during normal long-term storage, but the specific effects were genotype-dependent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Serum Metabolic Signatures Induced By a Three-Day Intensified Exercise Period Persist After 14 h of Recovery in Runners
JOURNAL OF PROTEOME RESEARCH, 12(10), 4577–4584.
author keywords: metabolomics; running; lipids; amino acids; carnitines
MeSH headings : Adult; Amino Acids / blood; Female; Gas Chromatography-Mass Spectrometry; Humans; Lipid Metabolism; Lipids / blood; Male; Metabolome; Middle Aged; Physical Exertion; Running / physiology; Young Adult
TL;DR:
Runners experienced a profound systemic shift in blood metabolites related to energy production especially from the lipid super pathway following 3 days of heavy exertion that was not fully restored to pre-exercise levels after 14 h recovery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Stable Binding of Alternative Protein-Enriched Food Matrices with Concentrated Cranberry Bioflavonoids for Functional Food Applications
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 61(28), 6856–6864.
Contributors: M. Grace n , I. Guzman n, D. Roopchand *, K. Moskal *, D. Cheng*, N. Pogrebnyak*, I. Raskin *, A. Howell *, n
author keywords: A-type proanthocyanidins; polyphenols; Vaccinium macrocarpon; antiadhesion; antimicrobial; shelf stability
MeSH headings : Anthocyanins / analysis; Anti-Bacterial Agents / administration & dosage; Arachis / chemistry; Beverages / analysis; Cannabis / chemistry; Dietary Proteins / metabolism; Flavonoids / metabolism; Food, Fortified; Fruit / chemistry; Functional Food; Plant Proteins / metabolism; Polyphenols / metabolism; Proanthocyanidins / analysis; Soybean Proteins / metabolism; Urinary Tract Infections / prevention & control; Vaccinium macrocarpon / chemistry
TL;DR:
Nutritional and sensory analyses indicated that the targeted CB-matrix combinations have high potential for incorporation in functional food formulations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Antiparasitic compounds from Cornus florida L. with activities against Plasmodium falciparum and Leishmania tarentolae
JOURNAL OF ETHNOPHARMACOLOGY, 142(2), 456–461.
Contributors: R. Graziose*, P. Rojas-Silva *, T. Rathinasabapathy , C. Dekock*, M. Grace n , A. Poulev *, M. Ann Lila n, P. Smith *, I. Raskin *
author keywords: Cornus; Antiplasmodial; Antileishmanial; Malaria; Cytotoxicity; Triterpene; Betulinic acid
MeSH headings : Animals; Antimalarials / isolation & purification; Antimalarials / pharmacology; Cell Line; Cornus / chemistry; Inhibitory Concentration 50; Leishmania / drug effects; Leishmaniasis / drug therapy; Muscle, Skeletal / drug effects; Myoblasts / drug effects; Phytotherapy; Plant Bark; Plant Extracts / chemistry; Plant Extracts / pharmacology; Plant Extracts / therapeutic use; Plasmodium falciparum / drug effects; Rats; Trypanocidal Agents / isolation & purification; Trypanocidal Agents / pharmacology; Trypanocidal Agents / therapeutic use
TL;DR:
The compounds isolated in this study, while displaying moderate in vitro antiplasmodial activity, do not fully support the historical importance of C. florida as an antimalarial remedy in North America.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Antiplasmodial activity of cucurbitacin glycosides from Datisca glomerata (C. Presl) Baill
PHYTOCHEMISTRY, 87, 78–85.
Contributors: R. Graziose*, M. Grace n , T. Rathinasabapathy , P. Rojas-Silva *, C. Dekock*, A. Poulev *, n , P. Smith *, I. Raskin *
author keywords: Datisca glomerata; Cucurbitales; Datiscaceae; Durango root; Bioassay guided fractionation; Cucurbitacin; Antimalarial; Antileishmanial; Cytotoxicity
MeSH headings : Animals; Antimalarials / chemistry; Antimalarials / pharmacology; CHO Cells; Cell Line; Cricetinae; Glycosides / chemistry; Glycosides / pharmacology; Magnoliopsida / chemistry; Molecular Structure; Plants, Medicinal / chemistry; Plasmodium falciparum / drug effects; Rats; Triterpenes / chemistry; Triterpenes / pharmacology
TL;DR:
The traditionally used antimalarial plant, Datisca glomerata (C. Presl) Baill, was subjected to antiplasmodial assay guided fractionation, which led to the isolation of seven cucurbitacin glycosides, datiscosides I-O, along with two known compounds from the aerial parts of D. glomersata, which displayed cytotoxicity against L6 but not CHO mammalian cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Antiplasmodial activity of the ethnobotanical plant Cassia fistula
Natural Product Communications, 7(10), 1263–1266.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Biochemical Analysis and in Vivo Hypoglycemic Activity of a Grape Polyphenol-Soybean Flour Complex
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 60(36), 8860–8865.
author keywords: Concord grape juice; defatted soy flour; anthocyanins; proanthocyanidins; polyphenols; hypoglycemic; diabetes
MeSH headings : Adsorption; Animals; Blood Glucose / metabolism; Flour / analysis; Humans; Hydrogen-Ion Concentration; Hyperglycemia / drug therapy; Hyperglycemia / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / chemistry; Male; Mice; Mice, Inbred C57BL; Polyphenols / administration & dosage; Polyphenols / chemistry; Soybeans / chemistry; Vitis / chemistry
TL;DR:
Grape polyphenol-enriched DSF can provide a high-protein, low-sugar ingredient for delivery of concentrated grape polyphenolics and was able to significantly lower blood glucose levels in hyperglycemic C57BL/6J mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice
PHARMACOLOGICAL RESEARCH, 68(1), 59–67.
author keywords: Metabolic syndrome; Diabetes; Blueberry; Soybean; Anthocyanins; Polyphenols
MeSH headings : Animals; Anthocyanins / pharmacology; Anthocyanins / therapeutic use; Blueberry Plants; Cell Line; Cell Line, Tumor; Cholesterol / blood; Flour; Glucose / metabolism; Hyperglycemia / drug therapy; Hyperglycemia / metabolism; Hypoglycemic Agents / pharmacology; Hypoglycemic Agents / therapeutic use; Male; Mice; Mice, Inbred C57BL; Myoblasts / metabolism; Polyphenols / pharmacology; Polyphenols / therapeutic use; Rats; Soybeans; Weight Gain / drug effects
TL;DR:
The results indicate that delivery of blueberry polyphenols stabilized in a high-protein food matrix may be useful for the dietary management of pre-diabetes and/or diabetes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Comparison of Health-Relevant Flavonoids in Commonly Consumed Cranberry Products
JOURNAL OF FOOD SCIENCE, 77(8), H176–H183.
Contributors: M. Grace n , A. Massey n, F. Mbeunkui n, G. Yousef n & n
author keywords: anthocyanins; cranberry; flavonoids; proanthocyanidins; processing
MeSH headings : Anthocyanins / analysis; Beverages; Biflavonoids / analysis; Catechin / analysis; Chromatography, High Pressure Liquid; Flavonoids / analysis; Food Handling / methods; Freeze Drying; Fruit / chemistry; Plant Extracts / analysis; Proanthocyanidins / analysis; Vaccinium macrocarpon / chemistry
TL;DR:
As cranberry juices and other products are increasingly consumed for their recognized health benefits (including prophylaxis against urinary tract infection), it is relevant to consider how various degrees of commercial and home processing can alter innate levels of the biologically active flavonoids characteristic to the intact fruits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Continuous Infusion of 20-Hydroxyecdysone Increased Mass of Triceps Brachii in C57BL/6 Mice
Phytotherapy Research, 27(1), 107–111.
author keywords: 20-hydroxyecdysone; infusion; mice; microarray; phytoecdysteroids; skeletal muscle
MeSH headings : Anabolic Agents / pharmacology; Animals; Ecdysterone / pharmacology; Gene Expression; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal / drug effects; Muscle, Skeletal / physiology; Oligonucleotide Array Sequence Analysis; Organ Size; Transcriptome
TL;DR:
Overall, the data suggest that 20E does not have potent anabolic properties, however, a muscle‐specific increase was observed and genes were identified to provide an explanation for the muscle accretion.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021
2012 journal article
Cucurbitacin glycosides from Datisca glomerata with antiplasmodial activity
Planta Medica, 78(11).
Source: Crossref
Added: September 9, 2020
2012 conference paper
Cucurbitacin glycosides from Datisca glomerata with antiplasmodial activity
Planta Medica, 78(11), 1245–1245.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix
FOOD CHEMISTRY, 135(4), 2994–3002.
author keywords: Cinnamomum burmannii; Cinnamon; Diabetes; Fasting blood glucose; Glucose production
MeSH headings : Animals; Cell Line; Cinnamomum zeylanicum / chemistry; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / enzymology; Diabetes Mellitus, Type 2 / genetics; Diabetes Mellitus, Type 2 / metabolism; Glucose / metabolism; Glucose-6-Phosphatase / genetics; Glucose-6-Phosphatase / metabolism; Humans; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / pharmacology; Male; Mice; Mice, Inbred C57BL; Phosphoenolpyruvate Carboxykinase (ATP) / genetics; Phosphoenolpyruvate Carboxykinase (ATP) / metabolism; Plant Extracts / administration & dosage; Plant Extracts / pharmacology; Polyphenols / administration & dosage; Polyphenols / pharmacology; Rats; Soy Foods / analysis
TL;DR:
CE and cinnamon polyphenol-enriched defatted soy flour (CDSF) were effective in acutely lowering fasting blood glucose levels in diet induced obese hyperglycemic mice at 300 and 600 mg/kg, respectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Isolation and characterization of flavonols from blackcurrant by high-performance counter-current chromatography and electrospray ionization tandem mass spectrometry
JOURNAL OF SEPARATION SCIENCE, 35(13), 1682–1689.
Contributors: F. Mbeunkui*, M. Grace* , G. Yousef* & M. Ann Lila n
author keywords: Blackcurrant (Ribes nigrum); Flavonols; High-performance counter-current chromatography; Liquid chromatography with tandem mass spectrometry
MeSH headings : Countercurrent Distribution / methods; Flavonols / chemistry; Flavonols / isolation & purification; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Ribes / chemistry; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
The results of these experiments demonstrated that high-performance counter-current chromatography along with ESI-MS(n) is a sensitive, selective, and effective technology for isolation and characterization of minor constituents from a complex mixture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Seeking novel Leishmanicidal natural products from common medicinal plants, the example of Eryngium foetidum L
Planta Medica, 78(11).
Source: Crossref
Added: September 9, 2020
2012 conference paper
Seeking novel Leishmanicidal natural products from common medicinal plants, the example of Eryngium foetidum L
Planta Medica, 78(11), 1132–1132.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Complementary Approaches To Gauge the Bioavailability and Distribution of Ingested Berry Polyphenolics
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 60(23), 5763–5771.
Contributors: n , D. Ribnicky *, L. Rojo *, P. Rojas-Silva *, A. Oren*, R. Havenaar *, E. Janle*, I. Raskin *, G. Yousef n, M. Grace n
author keywords: bioavailability; bioaccessibility; radiolabeling; artificial gastrointestinal tract
MeSH headings : Absorption; Animals; Anthocyanins / analysis; Anthocyanins / pharmacokinetics; Biological Availability; Blueberry Plants / chemistry; Carbon Isotopes / analysis; Carbon Isotopes / pharmacokinetics; Cell Line; Computer Simulation; Fruit / chemistry; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / metabolism; Humans; Models, Biological; Phytochemicals / analysis; Phytochemicals / pharmacokinetics; Polyphenols / analysis; Polyphenols / pharmacokinetics; Rats; Vitis / chemistry
TL;DR:
Two different strategies for investigating the likely fate, after ingestion, of natural, bioactive berry constituents (anthocyanins and other non-nutritive flavonoids) are compared.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2011 journal article
Efficient sorption of polyphenols to soybean flour enables natural fortification of foods
Food Chemistry, 131(4), 1193–1200.
Contributors: D. Roopchand *, M. Grace n , P. Kuhn *, D. Cheng*, N. Plundrich n, A. Poulev *, A. Howell *, B. Fridlender*, n , I. Raskin *
TL;DR:
It is demonstrated that defatted soybean flour (DSF) can sorb polyphenols from blueberry and cranberry juices while separating them from sugars, providing a means to create protein-rich food ingredients containing concentrated plant bioactives without excess sugars, fats and water that can be incorporated in a variety of scientifically validated functional foods and dietary supplements.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018
2011 journal article
In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis)
Food Chemistry, 131(2), 387–396.
Contributors: L. Rojo *, D. Ribnicky *, S. Logendra*, A. Poulev *, P. Rojas-Silva *, P. Kuhn *, R. Dorn*, M. Grace n , n , I. Raskin *
author keywords: Dietary anthocyanins; Metabolic syndrome; Glucose metabolism; Maqui Berry
TL;DR:
It is observed that oral administration of ANC improved fasting blood glucose levels and glucose tolerance in hyperglycaemic obese C57BL/6J mice fed a high fat diet and D3S5G also increased glucose uptake in L6 myotubes and is at least partially responsible for ANC's anti-diabetic properties.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
In vitro antiplasmodial activity of indole alkaloids from the stem bark of Geissospermum vellosii
JOURNAL OF ETHNOPHARMACOLOGY, 139(2), 471–477.
Contributors: F. Mbeunkui n, M. Grace n , C. Lategan*, P. Smith *, I. Raskin * & n
author keywords: Geissospermum vellosii; Apocynaceae; Indole alkaloids; Antiplasmodial activity; Malaria
MeSH headings : Animals; Antimalarials / chemistry; Antimalarials / isolation & purification; Antimalarials / pharmacology; Antimalarials / toxicity; Apocynaceae / chemistry; CHO Cells; Cell Survival / drug effects; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Indole Alkaloids / chemistry; Indole Alkaloids / isolation & purification; Indole Alkaloids / pharmacology; Indole Alkaloids / toxicity; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Parasitic Sensitivity Tests; Plant Bark; Plants, Medicinal; Plasmodium falciparum / drug effects
TL;DR:
Evidence is provided to support the use of Geissospermum vellosii as an antimalarial agent, as used by the native populations, as part of the ongoing investigations of new bioactive compounds with activity against malaria parasites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2011 journal article
Isolation and identification of antiplasmodial N-alkylamides from Spilanthes acmella flowers using centrifugal partition chromatography and ESI-IT-TOF-MS
Journal of Chromatography B, 879(21), 1886–1892.
Contributors: F. Mbeunkui n, M. Grace n , C. Lategan*, P. Smith*, I. Raskin * & n
author keywords: Centrifugal partition chromatography; N-alkylamides; Antiplasmodial activity
MeSH headings : Amides / chemistry; Amides / isolation & purification; Amides / pharmacology; Animals; Antimalarials / chemistry; Antimalarials / isolation & purification; Antimalarials / pharmacology; Asteraceae / chemistry; CHO Cells; Cell Survival / drug effects; Centrifugation; Chromatography, Liquid / methods; Cricetinae; Cricetulus; Flowers / chemistry; Nuclear Magnetic Resonance, Biomolecular; Plasmodium falciparum / drug effects; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
A systematic approach for investigating a suitable centrifugal partition chromatography (CPC) solvent system for N-alkylamides separation was reported, and CPC fractions demonstrated significantly higher antiplasmodial activity compared to corresponding purified N-alkinglamides, thus suggesting that interactions between these N-alklamides may potentiate antiplAsmodial bioactivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Isolation and structural elucidation of indole alkaloids from Geissospermum vellosii by mass spectrometry
Journal of Chromatography B, 885-886, 83–89.
Contributors: F. Mbeunkui n, M. Grace n & n
author keywords: Electrospray ionization tandem mass spectrometry; High performance counter-current chromatography; Indole alkaloids; Structural elucidation
MeSH headings : Apocynaceae / chemistry; Chromatography, High Pressure Liquid / methods; Countercurrent Distribution / methods; Indole Alkaloids / chemistry; Indole Alkaloids / isolation & purification; Molecular Conformation; Plant Bark / chemistry; Spectrometry, Mass, Electrospray Ionization / methods; Tandem Mass Spectrometry / methods
TL;DR:
The results of the experiments demonstrated that the combination of high performance counter current chromatography and ESI-MS(n) is a sensitive, selective and effective approach for rapid isolation and characterization of alkaloids from G. vellosii.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Promoting Wellness in Alaskan Villages: Integrating Traditional Knowledge and Science of Wild Berries
ECOHEALTH, 8(2), 199–209.
author keywords: traditional ecological knowledge; wild berries; environmental change; participatory research; youth; health; community wellness
MeSH headings : Alaska; Alcoholism / ethnology; Analysis of Variance; Climate Change; Community-Based Participatory Research; Environmental Pollution / adverse effects; Ethnobotany / methods; Feeding Behavior / ethnology; Focus Groups; Fruit / chemistry; Fruit / physiology; Health Knowledge, Attitudes, Practice / ethnology; Health Promotion / methods; Humans; Indians, North American; Interviews as Topic; Inuit; Social Behavior
TL;DR:
Multiple berry species were found to have powerful bioactive health properties for ameliorating metabolic syndrome as well as importance for community wellness and suggest the importance of incorporating locally available foods and socio-cultural traditions into community wellness programming.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: NC State University Libraries, Web Of Science
Added: August 6, 2018
2011 journal article
The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems
Food & Function, 2(5), 235.
MeSH headings : Animals; Biological Availability; Food; Genistein / analysis; Genistein / metabolism; Glucuronides / analysis; Glucuronides / metabolism; Glycosides / analysis; Glycosides / metabolism; Humans; Intestinal Mucosa / metabolism; Isoflavones / analysis; Isoflavones / metabolism; Liver / metabolism; Mass Spectrometry; Polyphenols / analysis; Polyphenols / metabolism
TL;DR:
Critical questions about the absorption and tissue uptake of complex polyphenols such as the proanthocyanins can be answered by labeling thesepolyphenols with (14)C-sucrose in plant cell culture and then purifying them for use in animal experiments, routinely carried out with great sensitivity, specificity and quantification by LC-tandem mass spectrometry.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: September 9, 2020
2011 review
The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems
[Review of ]. Food & Function, 2(5), 235–244.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Antioxidant Capacity and in Vitro Inhibition of Adipogenesis and Inflammation by Phenolic Extracts of Vaccinium floribundum and Aristotelia chilensis
Journal of Agricultural and Food Chemistry, 58(16), 8966–8976.
author keywords: Aristotelia chilensis; Vaccinium floribundum; adipogenesis; anthocyanins; inflammation; proanthocyanidins; obesity
MeSH headings : 3T3-L1 Cells; Adipogenesis / drug effects; Animals; Antioxidants / analysis; Cell Line; Elaeocarpaceae / chemistry; In Vitro Techniques; Inflammation / prevention & control; Mice; Phenols / chemistry; Plant Extracts / pharmacology; Polyphenols / analysis; Polyphenols / pharmacology; Vaccinium / chemistry
TL;DR:
The anthocyanins and proanthocyanidin-enriched fraction from V. floribundum and A. chilensis phytochemicals limit adipogenesis and inflammatory pathways in vitro, warranting further in vivo studies.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2010 journal article
Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L.
JOURNAL OF ETHNOPHARMACOLOGY, 133(1), 26–30.
Contributors: R. Graziose*, T. Rathinasabapathy , C. Lategan*, A. Poulev *, P. Smith *, M. Grace n , n , I. Raskin *
author keywords: Antimalarial; Aporphine alkaloids; Sesquiterpene lactones; Liriodendron tulipifera L.; Magnoliaceae; Cytotoxicity
MeSH headings : Alkaloids / chemistry; Alkaloids / isolation & purification; Alkaloids / pharmacology; Antimalarials / chemistry; Antimalarials / isolation & purification; Antimalarials / pharmacology; Aporphines / chemistry; Aporphines / isolation & purification; Aporphines / pharmacology; Lactones / chemistry; Lactones / isolation & purification; Lactones / pharmacology; Liriodendron / chemistry; Malaria / drug therapy; Phytotherapy; Plant Bark; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Extracts / pharmacology; Plant Leaves; Sesquiterpenes / chemistry; Sesquiterpenes / isolation & purification; Sesquiterpenes / pharmacology; United States
TL;DR:
This work supports the historical use of Liriodendron tulipifera as an antimalarial remedy of the United States and characterizes its antiplasmodial constituents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2010 journal article
Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana
Natural Product Communications, 5(12), 1869–1872.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Characterization of Anthocyanins and Proanthocyanidins in Wild and Domesticated Mexican Blackberries (Rubus spp.)
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 58(12), 7458–7464.
author keywords: Anthocyanin; proanthocyanidin; ellagitannins; Rubus; HPLC-ESI-MS
MeSH headings : Anthocyanins / analysis; Fruit / chemistry; Fruit / genetics; Genotype; Mexico; Plant Extracts / analysis; Proanthocyanidins / analysis; Rosaceae / chemistry; Rosaceae / genetics
TL;DR:
Recommendations for dietary intake of blackberries for human health benefits need to take into account the source, because of the wide inherent variation in bioactive polyphenolic content in different blackberry genotypes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Comparative in vitro bioactivities of tea extracts from six species of Ardisia and their effect on growth inhibition of HepG2 cells
Journal of Ethnopharmacology, 130(3), 536–544.
author keywords: Tea; Ardisia; Polyphenols; Liver cancer; HepG2; Apoptosis
MeSH headings : Antineoplastic Agents, Phytogenic / administration & dosage; Antineoplastic Agents, Phytogenic / pharmacology; Antioxidants / administration & dosage; Antioxidants / isolation & purification; Antioxidants / pharmacology; Apoptosis / drug effects; Ardisia / chemistry; Flavonoids / administration & dosage; Flavonoids / isolation & purification; Flavonoids / pharmacology; Hep G2 Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms / drug therapy; Liver Neoplasms / pathology; Medicine, Traditional; Phenols / administration & dosage; Phenols / isolation & purification; Phenols / pharmacology; Plant Extracts / administration & dosage; Plant Extracts / pharmacology; Polyphenols; Species Specificity; Tea / chemistry; Topoisomerase II Inhibitors
TL;DR:
Although the mechanism is not entirely clear, AC, ACR, and AJ are the Ardisia species with the greatest anticancer potential against liver cancer cells in vitro and deserve further investigation.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2010 journal article
Inhibition of Pro-inflammatory Responses and Antioxidant Capacity of Mexican Blackberry (Rubus spp.) Extracts
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 58(17), 9542–9548.
author keywords: Inflammation; wild blackberries; polyphenolic-rich fractions (PAE); antioxidant capacity; anthocyanins (ANC); proanthocyanidins (PAC); Rubus
MeSH headings : Animals; Antioxidants / pharmacology; Cell Line; Inflammation Mediators / pharmacology; Mice; Plant Extracts / pharmacology; Rosaceae / chemistry
TL;DR:
Wild genotypes of Mexican blackberries, as rich sources of polyphenolics that have both antioxidant and anti-inflammatory properties, showed particular promise for inclusion in plant improvement programs designed to develop new varieties with nutraceutical potential.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Screening and Selection of High Carotenoid Producing in Vitro Tomato Cell Culture Lines for [13C]-Carotenoid Production
Journal of Agricultural and Food Chemistry, 58(18), 9979–9987.
author keywords: Solanum lycopersicum; Solanum pimpinellifolium; plant cell culture; lycopene; phytoene; metabolic tracing; isotopic labeling; carotenoids; tomato; nutrition; metabolism
MeSH headings : Carbon Isotopes; Carotenoids / biosynthesis; Cell Line; Isotope Labeling / methods; Solanum lycopersicum / cytology; Solanum lycopersicum / metabolism
TL;DR:
This is the first report of highly enriched 13C-carotenoid production from in vitro plant cell culture and the best producers with or without the bleaching herbicides, norflurazon and 2-(4-chlorophenyl-thio)triethylamine (CPTA).
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021
2009 journal article
Alaskan wild berry resources and human health under the cloud of climate change
Journal of Agricultural and Food Chemistry, 58(7), 3884–3900.
MeSH headings : Alaska; Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Blood Glucose / drug effects; Cell Line; Climate Change; Fruit / chemistry; Health; Humans; Male; Mice; Mice, Inbred C57BL; Obesity / drug therapy; Plant Extracts / analysis; Plant Extracts / metabolism; Plant Extracts / pharmacology; Random Allocation; Rosaceae / chemistry
TL;DR:
Local observations provided robust insights into effects of climatic fluctuations on berry abundance and quality, and preliminary site-specific compositional and bioactivity differences were noted, suggesting the need to monitor this Alaska Native resource as climate shifts affect the region.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
13. Climate Action
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2009 journal article
Herbicide Treatments Alter Carotenoid Profiles for14C Tracer Production from Tomato (Solanum lycopersicum cv. VFNT cherry) Cell Cultures
Journal of Agricultural and Food Chemistry, 57(11), 4614–4619.
author keywords: Solanum lycopersicum; bleaching herbicide; radiolabeling; metabolic tracer; cell culture; lycopene; phytoene; phytofluene
MeSH headings : Carbon Radioisotopes / metabolism; Carotenoids / metabolism; Cells, Cultured; Herbicides / pharmacology; Solanum lycopersicum / drug effects; Solanum lycopersicum / metabolism
TL;DR:
Improved culture conditions efficiently provided sufficient (14)C-carotenoids for future cell culture and animal metabolic tracking studies and led to a small increase in labeling efficiency.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021
2009 journal article
Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton
Phytomedicine, 16(5), 406–415.
Contributors: M. Grace* , D. Ribnicky *, P. Kuhn *, A. Poulev *, S. Logendra*, G. Yousef *, I. Raskin *, *
author keywords: Blueberry; Vaccinium angustifolium; Anthocyanins; Malvidin; Diabetes; Hyperglycemia; Hypoglycemia; Labrasol
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Blood Glucose / drug effects; Blueberry Plants; Drug Delivery Systems; Drug Therapy, Combination; Glucosides / analysis; Glucosides / pharmacology; Glycerides; Hypoglycemic Agents / chemistry; Hypoglycemic Agents / pharmacology; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Organic Chemicals / administration & dosage; Organic Chemicals / pharmacology; Phenols / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology
TL;DR:
It is demonstrated that anthocyanins from blueberry have the potency to alleviate symptoms of hyperglycemia in diabetic C57b1/6J mice and their bio-enhancing effect, most likely due to increasing the bioavailability of the administered preparations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019
2009 journal article
In vitro and in vivo evaluation of the prebiotic activity of water-soluble blueberry extracts
World Journal of Microbiology and Biotechnology, 25(7), 1243–1249.
author keywords: Blueberry extract; Prebiotic activity; Lactobacilli; Bifidobacteria
TL;DR:
The results demonstrated for the first time that addition of BBE from both cultivars to broth media containing pure cultures of Lactobacilli and Bifidobacteriumbreve resulted in a significant increase in the population size of these strains.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2009 journal article
In vitro production of radiolabeled red clover (Trifolium pratense) isoflavones
Plant Cell, Tissue and Organ Culture (PCTOC), 98(2), 147–156.
author keywords: Red clover; Isoflavones; Metabolic tracers; Plant cell culture; Copper chloride; Radiolabeling; Trifolium pratense
TL;DR:
Varying levels and timing of copper chloride elicitor did not significantly affect isoflavone accumulation, and approximately 38% of the 14C-sucrose dose accumulated in the cells.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2009 journal article
In vivo metabolic tracking of 14C-radiolabelled isoflavones in kudzu (Pueraria lobata) and red clover (Trifolium pratense) extracts
British Journal of Nutrition, 102(10), 1523–1530.
author keywords: Kudzu; Red clover; Radiolabelling; Pharmacokinetics
MeSH headings : Animals; Carbon / chemistry; Carbon Radioisotopes; Cells, Cultured; Extracellular Fluid / chemistry; Isoflavones / blood; Isoflavones / chemistry; Isoflavones / metabolism; Male; Plant Roots / cytology; Pueraria / chemistry; Rats; Rats, Sprague-Dawley; Time Factors; Trifolium / chemistry
TL;DR:
Serum pharmacokinetics suggest that extracts from kudzu may undergo enterohepatic circulation, and both extracts were rapidly absorbed, distributed in various tissues, and largely eliminated in the urine and faeces.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021
2009 journal article
Method for evaluating the potential of 14C labeled plant polyphenols to cross the blood–brain barrier using accelerator mass spectrometry
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 268(7-8), 1313–1316.
author keywords: Blood-brain barrier; Grape polyphenols; Pharmacokinetics; Accelerator mass spectrometry; C-14 labeled plant polyphenols
TL;DR:
Using AMS in combination with traditional methods, it is possible to study uptake by blood, distribution to ISF and determine the amount of a dose which can reach the brain and follow the pharmacokinetics in the brain.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2009 journal article
Research highlights from the Purdue-UAB Botanicals Research Center for Age Related Diseases
Pharmaceutical Biology, 47(8), 768–773.
author keywords: Botanicals; isoflavones; catechins; bone resorption; cognitive function; cancer
TL;DR:
The Purdue-UAB Botanicals Research Center for Age Related Disease uses multidisciplinary and innovative technologies to investigate the bioavailability of bioactive polyphenolic constituents from botanicals and their relationship to human health.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2008 journal article
In vitro production of metabolism-enhancing phytoecdysteroids from Ajuga turkestanica
Plant Cell, Tissue and Organ Culture, 93(1), 73–83.
Contributors: D. Cheng*, G. Yousef *, M. Grace* , R. Rogers*, J. Gorelick-Feldman*, I. Raskin *, *
author keywords: 20-Hydroxyecdysone; cell suspension culture; cyasterone; hairy root; methyl jasmonate; mevalonic acid; turkesterone
TL;DR:
The results suggest that sustainable production of metabolically active phytoecdysteroid can be achieved through hairy root culture systems.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019
2008 journal article
Influence of Alternative Liquid Chromatography Techniques on the Chemical Complexity and Bioactivity of Isolated Proanthocyanidin Mixtures
Journal of Agricultural and Food Chemistry, 56(6), 1896–1906.
author keywords: proanthocyanidins; wild blueberry; Vaccinium angustifolium Ait.; Toyopearl HW-40; sephadex; LH-20; silica gel type G; topolsomerase II bioassay
MeSH headings : Chromatography, High Pressure Liquid; Chromatography, Liquid / methods; Enzyme Inhibitors / pharmacology; Humans; Plant Extracts / chemistry; Plant Extracts / pharmacology; Proanthocyanidins / chemistry; Proanthocyanidins / isolation & purification; Spectrometry, Mass, Electrospray Ionization; Topoisomerase II Inhibitors
TL;DR:
A 2(3) factorial analysis revealed that the vacuum and open column strategies for separation did not yield significantly different results in terms of mass recovery, DP, or bioactivity; however, interactions with other factors such as matrix or subfraction series resulted in distinctive shifts in fraction profiles and biological activity.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2008 journal article
Isolation of Radiolabeled Isoflavones from Kudzu (Pueraria lobata) Root Cultures
Journal of Agricultural and Food Chemistry, 56(17), 7860–7865.
author keywords: kudzu; Pueraria lobata; isoflavones; puerarin; daidzein
MeSH headings : Carbon Radioisotopes; Isoflavones / analysis; Isoflavones / isolation & purification; Isotope Labeling; Plant Roots / chemistry; Pueraria / chemistry; Tissue Culture Techniques
TL;DR:
The isolated isoflavones isolated from kudzu root cultures were sufficiently (14)C-labeled to permit utilization for subsequent in vivo metabolic tracking studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2008 journal article
Neo-clerodane diterpenes from Ajuga turkestanica
Phytochemistry Letters, 1(2), 81–84.
Contributors: M. Grace* , D. Cheng*, I. Raskin * & *
author keywords: Ajuga turkestanica; Labiatae; Neo-clerodane diterpenes; 14,15-Dihydroajugachin B; 14-Hydro-15-methoxyajugachin B
TL;DR:
The ethyl acetate extract of the aerial parts of Ajuga turkestanica afforded 6 neo-clerodane diterpenes, including two novel compounds, 14, 15-dihydroajugachin B and 14-hydro-15-methoxyajugaches B and chamaepitin, which were elucidated through exhaustive NMR spectroscopic analysis and chemical transformation.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019
2008 journal article
Optimization of Lycopene Extraction from Tomato Cell Suspension Culture by Response Surface Methodology
Journal of Agricultural and Food Chemistry, 56(17), 7710–7714.
author keywords: tomato; cell culture; lycopene; extraction; RSM
MeSH headings : Carotenoids / analysis; Carotenoids / isolation & purification; Cell Culture Techniques; Chromatography, High Pressure Liquid; Ethanol; Fruit / chemistry; Fruit / cytology; Hydroxides; Lycopene; Solanum lycopersicum / chemistry; Organophosphates; Plant Extracts / chemistry; Potassium Compounds; Statistics as Topic
TL;DR:
These optimal conditions predicted by RSM were confirmed to enhance lycopene yield from standardized tomato cell cultures by more than 3-fold.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2008 journal article
Phytochemical Composition and Metabolic Performance-Enhancing Activity of Dietary Berries Traditionally Used by Native North Americans
Journal of Agricultural and Food Chemistry, 56(3), 654–660.
author keywords: Amelanchier alnifolia; Viburnum trilobum; Prunus virginiana; Shepherdia argentea; diabetes; inflammation; energy expenditure
MeSH headings : Aldehyde Reductase / antagonists & inhibitors; Anthocyanins / analysis; Diet; Elaeagnaceae / chemistry; Energy Metabolism / drug effects; Flavonoids / analysis; Fruit / chemistry; Humans; Indians, North American; Plant Extracts / chemistry; Prunus / chemistry; Rosaceae / chemistry; Viburnum / chemistry
TL;DR:
Four wild berry species integral to the traditional subsistence diet of Native American tribal communities contain a rich array of phytochemicals that have the capacity to promote health and protect against chronic diseases, such as diabetes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2008 journal article
Phytoecdysteroids Increase Protein Synthesis in Skeletal Muscle Cells
Journal of Agricultural and Food Chemistry, 56(10), 3532–3537.
author keywords: ecdysteroid; ajuga; spinach; protein synthesis; skeletal muscle; myotube; C2C12
MeSH headings : Ajuga / chemistry; Animals; Cell Line; Ecdysteroids / analysis; Ecdysteroids / pharmacology; Ecdysterone / pharmacology; Humans; Male; Mice; Muscle Cells / drug effects; Muscle Cells / metabolism; Muscle Fibers, Skeletal / drug effects; Muscle Fibers, Skeletal / metabolism; Muscle, Skeletal / drug effects; Muscle, Skeletal / metabolism; Plants / chemistry; Protein Biosynthesis / drug effects; Rats; Rats, Sprague-Dawley; Spinacia oleracea / chemistry
TL;DR:
An in vitro cellular assay of protein synthesis was developed and found that phytoecdysteroids increased protein synthesis by up to 20% and ecdysteroid-containing plant extracts produced similar results, which suggests a PI3K-mediated mechanism.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2008 journal article
Plant extracts from central Asia showing antiinflammatory activities in gene expression assays
Phytotherapy Research, 22(7), 929–934.
author keywords: antiinflammatory natural product; gene expression; real-time RT-PCR
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Asia, Central; Cell Survival / drug effects; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Dose-Response Relationship, Drug; Gene Expression / drug effects; Gene Expression Profiling; Inhibitory Concentration 50; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; Macrophages / drug effects; Macrophages / metabolism; Medicine, East Asian Traditional; Mice; Nitric Oxide Synthase Type II / genetics; Nitric Oxide Synthase Type II / metabolism; Phytotherapy; Plant Extracts / pharmacology; Plants, Medicinal / chemistry; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
A mouse macrophage‐based quantitative, reverse transcription polymerase chain reaction (qRT‐PCR) system was optimized to screen plant extracts for antiinflammatory activities using three well known genetic markers of inflammation, and extracts identified were able to reduce inflammatory symptoms in vivo.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2007 journal article
Antiradical Capacity and Induction of Apoptosis on HeLa Cells by a Phaseolus vulgaris Extract
Plant Foods for Human Nutrition, 63(1), 35–40.
author keywords: antiradical capacity; apoptosis; HeLa cells; Phaseolus vulgaris L; phenolic compounds
MeSH headings : Apoptosis / drug effects; Biphenyl Compounds; Dose-Response Relationship, Drug; Free Radical Scavengers; HeLa Cells; Humans; Hydrazines; Phaseolus / chemistry; Picrates; Plant Extracts / analysis; Plant Extracts / pharmacology; Proanthocyanidins / analysis; Proanthocyanidins / pharmacology
TL;DR:
The results suggest that black Jamapa bean could be an important source of polyphenolic compounds with potential biological use as antioxidant and anticancer agents.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021
2007 journal article
Physiological and biochemical responses of tomato microshoots to induced salinity stress with associated ethylene accumulation
Plant Growth Regulation, 51(2), 159–169.
author keywords: ethylene; In vitro; microshoot; salinity; tomato
TL;DR:
The results indicate that the increase in ethylene under salinity stress is not the primary factor contributing to salinity’s deleterious effect on tomato plant growth and physiology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2007 journal article
Phytoene, phytofluene, and lycopene from tomato powder differentially accumulate in tissues of male Fisher 344 rats
Nutrition Research, 27(12), 794–801.
author keywords: carotenoids; phytoene; phytofluene; lycopene; prostate cancer; rats
TL;DR:
Results indicate that the relative tomato carotenoid biodistribution differs in liver and androgen-sensitive tissues, suggesting that minor changes in the number of sequential double bonds in carotanoid structures alter absorption and/or metabolism of tomato carOTenoids.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2007 journal article
Satiety in rats following blueberry extract consumption induced by appetite-suppressing mechanisms unrelated to in vitro or in vivo antioxidant capacity
Food Chemistry, 107(3), 1039–1044.
author keywords: blueberry; cultivars; satiety; rats; antioxidant; FRAP
TL;DR:
The observed results suggest that the reduction in food intake and decrease in body weight in experimental animals is not merely a consequence of antioxidant mechanisms, and BBE may provide a good satiety inducer and weight management modulator.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2006 journal article
Biosynthesis of14C-Phytoene from Tomato Cell Suspension Cultures (Lycopersicon esculentum) for Utilization in Prostate Cancer Cell Culture Studies
Journal of Agricultural and Food Chemistry, 54(3), 747–755.
author keywords: phytoene; phytofluene; carotenoids; tomato; Lycopersicon esculentum; prostate cancer; norflurazon
MeSH headings : Adenocarcinoma / metabolism; Carbon Radioisotopes; Carotenoids / biosynthesis; Carotenoids / metabolism; Cell Line, Tumor; Cells, Cultured; Humans; Isotope Labeling / methods; Solanum lycopersicum / metabolism; Male; Prostatic Neoplasms / metabolism
TL;DR:
The ability to biosynthesize, radiolabel, and isolate these carotenoids from tomato cell cultures is a novel, valuable methodology for further in vitro and in vivo investigations into the roles of phytoene and phy tofluene in cancer chemoprevention.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021
2006 journal article
Catalytic Inhibition of Human DNA Topoisomerase II by Interactions of Grape Cell Culture Polyphenols
Journal of Agricultural and Food Chemistry, 54(6), 2083–2087.
author keywords: chemopreventive agents; grape cell culture; isobolographic analysis; resveratrol; synergistic interactions; topoisomerase II catalytic inhibition; Vitis
MeSH headings : Catalysis; DNA Topoisomerases, Type II / metabolism; Drug Interactions; Drug Synergism; Enzyme Inhibitors / pharmacology; Flavonoids / pharmacology; Fruit / chemistry; Humans; Phenols / pharmacology; Polyphenols; Topoisomerase II Inhibitors; Vitis / chemistry
TL;DR:
Evaluated the potency of, and potential interactions between, individual fractions and some of the purified bioactive polyphenols that comprise these fractions on human DNA topoisomerase II catalytic activity and demonstrated potentiating interactions between the PB2 and the other polyphenolic constituents mentioned above and between myricetin and resveratrol.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2006 journal article
Chemopreventive Activity of Polyphenolics from Black Jamapa Bean (Phaseolus vulgarisL.) on HeLa and HaCaT Cells
Journal of Agricultural and Food Chemistry, 54(6), 2116–2122.
author keywords: Phaseolus vulgaris; polyphenolic compounds; cytotoxicity; HeLa cells; HaCaT cells
MeSH headings : Anticarcinogenic Agents / pharmacology; Apoptosis / drug effects; Cell Adhesion / drug effects; Cell Cycle / drug effects; Cell Division / drug effects; Cell Line, Tumor; Flavonoids / pharmacology; HeLa Cells; Humans; Keratinocytes; Methanol; Phaseolus / chemistry; Phenols / pharmacology; Plant Extracts / pharmacology; Polyphenols; Precancerous Conditions; Seeds / chemistry; Skin Neoplasms
TL;DR:
The results indicated that black Jamapa beans could be a source of polyphenolic compounds, which have an inhibitory effect toward HeLa cancer cells but are less aggressive on HaCaT premalignant cells.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021
2006 journal article
Comparative phytochemical characterization of three Rhodiola species
Phytochemistry, 67(21), 2380–2391.
Contributors: G. Yousef *, M. Grace* , D. Cheng*, I. Belolipov*, I. Raskin * & *
author keywords: Rhodiola heterodonta; Rhodiola semenovii; Rhodiola rosea; Crassulaceae; heterodontoside; phenylethanoid glycosides; cyanogenic glucosides; proanthocyanidins; prodelphinidins; EGCG; EGC; HPLC-ESI-MS
MeSH headings : Glucosides / chemistry; Glycosides / chemistry; Molecular Structure; Phenols / chemistry; Proanthocyanidins / chemistry; Rhodiola / chemistry; Rhodiola / classification; Rhodiola / metabolism; Species Specificity
TL;DR:
This study resulted in the identification and isolation of phytochemical constituents for direct cross-comparison between three Rhodiola species of medicinal and pharmacological value.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019
2006 journal article
Cytotoxicity of bioactive polymeric fractions from grape cell culture on human hepatocellular carcinoma, murine leukemia and non-cancerous PK15 kidney cells
Food and Chemical Toxicology, 44(10), 1758–1767.
author keywords: human hepatocellular carcinoma cells; mouse leukemia cells; grape cell culture; proanthocyanidin oligomers
MeSH headings : Animals; Carcinoma, Hepatocellular / drug therapy; Cell Line; Cell Line, Tumor; Flavonoids / pharmacology; Humans; Kidney / drug effects; Leukemia L1210 / drug therapy; Liver Neoplasms / drug therapy; Mice; Plant Extracts / pharmacology; Vitis / chemistry; Vitis / cytology
TL;DR:
Because TP-6 and its subfractions were selectively cytotoxic to cancerous cell lines tested, they warrant further investigation as potential natural anticancer agents.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2006 journal article
Identification of isoflavone glycosides inPueraria lobata cultures by tandem mass spectrometry
Phytochemical Analysis, 18(1), 50–59.
author keywords: HPLC-UV-MS; metabolic profiling; isoflavone profiling; puerarin; in vitro cultures; Pueraria lobata
MeSH headings : Cells, Cultured; Chromatography, High Pressure Liquid; Glycosides / analysis; Isoflavones / analysis; Mass Spectrometry; Plant Roots / chemistry; Pueraria / chemistry; Spectrophotometry, Ultraviolet
TL;DR:
The molecular weights, interpretation of characteristic fragment ions obtained from HPLC-MS/MS and comparison with reported data allowed the putative identification of the isoflavone metabolites.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021
2006 journal article
The nature-versus-nurture debate on bioactive phytochemicals: the genome versus terroir
Journal of the Science of Food and Agriculture, 86(15), 2510–2515.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 12, 2021
2006 journal article
ent-Beyerane diterpenoids from the heartwood of Excoecaria parvifolia
Phytochemistry, 68(4), 546–553.
Contributors: M. Grace* , J. Faraldos *, * & R. Coates*
MeSH headings : Diterpenes / chemistry; Diterpenes / isolation & purification; Euphorbiaceae / chemistry; Models, Molecular; Molecular Structure; Plant Oils / chemistry; Wood
TL;DR:
Diosphenol 2 and nor-lactone 5 exhibited significant potency in bioassays for cytotoxic activity against leukemia cells (L1210).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019
2005 journal article
Characterization of Polyphenolics in the Seed Coat of Black Jamapa Bean (Phaseolus vulgarisL.)
Journal of Agricultural and Food Chemistry, 53(11), 4615–4622.
MeSH headings : Anthocyanins / analysis; Chemical Fractionation; Chromatography, High Pressure Liquid; Flavonoids / analysis; Flavonoids / isolation & purification; Mass Spectrometry; Methanol; Phaseolus / chemistry; Phenols / analysis; Phenols / isolation & purification; Plant Extracts / chemistry; Polyphenols; Proanthocyanidins / analysis; Seeds / chemistry
TL;DR:
This is the first time that myricetin glycoside and proanthocyanidin oligomers containing (epi)-gallocatechin have been reported in the black bean, and a better separation of phytochemicals was achieved using direct silica gel fractionation.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021
2005 journal article
Differential effects of blueberry proanthocyanidins on androgen sensitive and insensitive human prostate cancer cell lines
Cancer Letters, 231(2), 240–246.
author keywords: vaccinium; blueberry; prostate cancer; antiproliferation; proanthocyanidin
MeSH headings : Androgens / metabolism; Blueberry Plants / chemistry; Cell Proliferation / drug effects; Humans; Magnetic Resonance Spectroscopy; Male; Neoplasms, Hormone-Dependent / drug therapy; Proanthocyanidins / therapeutic use; Prostatic Neoplasms / drug therapy; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured
TL;DR:
Differences in cell growth inhibition of LNCaP and DU145 cell lines by blueberry fractions rich in proanthocyanidins indicate that blueberry proantho-phenolic compounds have an effect primarily on androgen-dependant growth of prostate cancer cells.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2005 journal article
Effects of Grape Cell Culture Extracts on Human Topoisomerase II Catalytic Activity and Characterization of Active Fractions
Journal of Agricultural and Food Chemistry, 53(7), 2489–2498.
author keywords: human topoisomerase II; catalytic inhibitor; antitopoisomerase II activity; Vitis; grape cell culture; chemopreventive agents
MeSH headings : Anticarcinogenic Agents; Cells, Cultured; Chemical Fractionation; Chromatography, High Pressure Liquid; Culture Media, Conditioned; DNA Topoisomerases, Type II / metabolism; Enzyme Inhibitors / isolation & purification; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Flavonoids / isolation & purification; Flavonoids / metabolism; Flavonoids / pharmacology; Glucosides / analysis; Humans; Phenols / isolation & purification; Phenols / metabolism; Phenols / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology; Polyphenols; Proanthocyanidins / analysis; Spectrometry, Mass, Electrospray Ionization; Vitis / metabolism
TL;DR:
The significant potency especially of TP-4 and TP-6 from grape cell cultures suggests that these fractions may have potential as chemopreventive agents.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2005 journal article
Screening Growth and Root Formation in Cadmium-Treated Turfgrass Using a Whole-Plant Microculture System
Journal of Plant Nutrition, 28(6), 1041–1048.
author keywords: bermudagrass; seashore paspalum; whole-plant microculture; phytoremediation
TL;DR:
Microculture at the whole-plant level in vitro enables intact root growth observations through the culture medium and vessel, and offers a potential pre-screening method for putative heavy-metal-tolerant turfgrasses before commercialization and use in phytoremediation to clean up contaminated soils.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2004 journal article
An enclosed-chamber labeling system for the safe 14C-enrichment of phytochemicals in plant cell suspension cultures
In Vitro Cellular & Developmental Biology - Plant, 40(1), 80–85.
author keywords: flavonoids; radiolabel; Vaccinium pahalae; ohelo berry; Vitis vinifera; grape
TL;DR:
An enclosed-chamber labeling system in which cell suspension cultures can be safely and efficiently grown when supplied with 14C-enriched precursors and showed that flavonoids were produced with either sucrose or glucose as the carbohydrate source, although flavonoid productivity was higher with sucrose.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2004 journal article
Biosynthesis and Characterization of14C-Enriched Flavonoid Fractions from Plant Cell Suspension Cultures
Journal of Agricultural and Food Chemistry, 52(5), 1138–1145.
author keywords: radiolabeling; proanthocyanidins; anthocyanins; flavonoid-rich fractions; ohelo (Vaccinium); grape (Vitis)
MeSH headings : Anthocyanins / analysis; Anthocyanins / biosynthesis; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Flavonoids / analysis; Flavonoids / biosynthesis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Vaccinium / metabolism; Vitis / metabolism
TL;DR:
A range of radiolabeled anthocyanins, proanthocyanidins, and other flavonoids were accumulated by cell suspension cultures of two plant species, ohelo and grape, after providing uniformly labeled sucrose to the medium to gauge their bioavailability and accumulation in target organs.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021
2004 journal article
Effective Separation of Potent Antiproliferation and Antiadhesion Components from Wild Blueberry (Vaccinium angustifoliumAit.) Fruits
Journal of Agricultural and Food Chemistry, 52(21), 6433–6442.
author keywords: Vaccinium angustifolium Ait.; blueberry; antiproliferation; antiadhesion; proanthocyanidin; condensed tannins
MeSH headings : Animals; Bacterial Adhesion / drug effects; Cell Division / drug effects; Escherichia coli; Humans; Liver Neoplasms, Experimental / pathology; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Polymers / chemistry; Proanthocyanidins / chemistry; Proanthocyanidins / isolation & purification; Proanthocyanidins / pharmacology; Prostatic Neoplasms / pathology; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Tumor Cells, Cultured; Vaccinium / chemistry
Sources: Crossref, NC State University Libraries
Added: January 24, 2021
Employment
Updated: December 21st, 2023 10:00
2008 - 2026
NCSU Kannapolis, NC, US
Director
FBNS
Education
Updated: March 28th, 2017 21:23
1980 - 1984
University of Wisconsin Madison Madison, WI, US
PhD
Hort/Botany
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