Works (230)

Updated: March 5th, 2026 09:21

2026 article

Partially hydrolyzed lentil and pea protein isolates: Techno-functional properties and bioactivity

Amin, U., Grace, M. H., Lila, M. A., & Zheng, H. (2026, February 26). Food Chemistry.

By: U. Amin n, M. Grace n, M. Lila n & H. Zheng n

topics (OpenAlex): Protein Hydrolysis and Bioactive Peptides; Proteins in Food Systems; Probiotics and Fermented Foods
Source: ORCID
Added: February 26, 2026

2026 article

Wild blueberries and cardiometabolic health: a current review of the evidence

Johnson, S. A., Klimis-Zacas, D., Basu, A., Bolling, B. W., Feresin, R. G., Hooshmand, S., … Weir, T. L. (2026, January 24). Critical Reviews in Food Science and Nutrition.

By: S. Johnson*, D. Klimis-Zacas, A. Basu*, B. Bolling*, R. Feresin*, S. Hooshmand*, P. Joris*, Z. Li* ...

topics (OpenAlex): Berry genetics and cultivation research; Biofield Effects and Biophysics; Phytochemicals and Antioxidant Activities
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: January 24, 2026

2025 article

Berry Fruit Extracts as Topical Cosmeceuticals for Skin Health Applications: A Systematic Review

Azevedo, F. S., Pires, A. R., Lila, M. A., Valacchi, G., Hoskin, R. T., Sarandy, M. M., … Goncalves, R. V. (2025, April 23). Cosmetics, Vol. 12.

author keywords: fruits; anti-inflammatory; antioxidant; murine; inflammatory markers
topics (OpenAlex): Bee Products Chemical Analysis; Phytochemicals and Antioxidant Activities; Essential Oils and Antimicrobial Activity
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 23, 2025

2025 article

Betalain–Chickpea Protein Particles Produced by Freeze Drying and Spray Drying: Physicochemical Aspects, Storage Stability, and In Vitro Digestion

Grace, M. H., Hoskin, R. T., Alghamdi, M., Lila, M. A., & Chalova, V. I. (2025, January 16). Foods, Vol. 14.

By: M. Grace n, R. Hoskin n, M. Alghamdi n, M. Lila n & V. Chalova n

author keywords: plant based; pigments; protein-rich particles; valorization; delivery method
topics (OpenAlex): Botanical Research and Applications; Microencapsulation and Drying Processes; Proteins in Food Systems
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 16, 2025

2025 article

Bioavailability and pharmacokinetics of (poly)phenols following consumption of selected blueberries and a blueberry-rich protein bar by adult males and females: a randomized, crossover, controlled trial

Santana, M. C., Rathore, A. S., Chandra, P., Everhart, J. L., Schulz, H., Granillo, C. D., … Kay, C. D. (2025, February 1). American Journal of Clinical Nutrition, Vol. 121, pp. 779–794.

By: M. Santana n, A. Rathore n, P. Chandra n, J. Everhart n, H. Schulz n, C. Granillo n, M. Ferruzzi*, M. Iorizzo* ...

author keywords: bioavailability; blueberry; (poly)phenolic-derived metabolites; phenotypic selection; protein bar
MeSH headings : Humans; Blueberry Plants / chemistry; Male; Adult; Biological Availability; Female; Cross-Over Studies; Fruit / chemistry; Polyphenols / pharmacokinetics; Middle Aged; Young Adult; Phenols / pharmacokinetics
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Antioxidant Activity and Oxidative Stress; Sensory Analysis and Statistical Methods
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 14, 2025

2025 article

Down the Rabbit Hole: How Digital Media Shapes Public Perceptions of Food Science and Technology Research (And How We Can Safeguard Science Integrity and Credibility)

Lila, M. A., Ryan, C., & Diekman, C. (2025, February 19). Annual Review of Food Science and Technology, Vol. 16, pp. 459–479.

By: M. Lila n, C. Ryan* & C. Diekman*

author keywords: artificial intelligence; social media; online; gene editing; alternative; proteins; health-relevant functional foods
MeSH headings : Social Media; Humans; Food Technology; Public Opinion; Mass Media; Digital Media
topics (OpenAlex): Misinformation and Its Impacts
Sources: Web Of Science, NC State University Libraries
Added: May 19, 2025

2025 article

Identification and functional characterization of BAHD acyltransferases associated with anthocyanin acylation in blueberry

Mengist, M. F., Abid, M. A., Grace, M. H., Seth, R., Bassil, N., Kay, C. D., … Iorizzo, M. (2025, February 10). Horticulture Research, Vol. 2.

By: M. Mengist n, M. Abid n, M. Grace n, R. Seth n, N. Bassil*, C. Kay n, A. Dare*, D. Chagné* ...

Contributors: R. Seth n

topics (OpenAlex): Horticultural and Viticultural Research; Plant Pathogens and Fungal Diseases; Plant Gene Expression Analysis
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 28, 2025

2024 article

Anti-Glioblastoma Potential and Phenolic Profile of Berry Juices

Kopjar, M., Raucher, D., Lila, M. A., & Šimunović, J. (2024, January 23). Processes, Vol. 12.

By: M. Kopjar*, D. Raucher*, M. Lila n & J. Šimunović n

author keywords: anthocyanins; antiproliferative potential; dwarf elderberry juice; raspberry juice; wild blackberry juice
topics (OpenAlex): Glioma Diagnosis and Treatment; Neurological Disease Mechanisms and Treatments; Microbial Metabolism and Applications
TL;DR: Wild blackberry juice demonstrated the highest potency, surpassing temozolomide in inhibiting GBM43 cell proliferation, suggesting its superiority over the conventional treatment of glioblastoma. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 26, 2024

2024 journal article

Assessing predictability of post-storage texture and appearance characteristics in blueberry at breeding population level

Postharvest Biology and Technology, 214, 112964.

By: M. Mengist n, M. Pottorff n, T. Mackey*, F. Ferrao*, G. Casorzo*, M. Lila n, C. Luby*, L. Giongo* ...

author keywords: Blueberry; Fruit characteristics; Shelf -life; Predictability; Breeding
topics (OpenAlex): Berry genetics and cultivation research; Horticultural and Viticultural Research; Plant Physiology and Cultivation Studies
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 11, 2024

2024 article

Bioactive Compounds, Antioxidant Activity, and Antiproliferative Potential on Glioblastoma Cells of Selected Stone Fruit Juices

Raucher, D., Rowsey, M., Hinson, J., Ćorković, I., Lila, M. A., Šimunović, J., & Kopjar, M. (2024, June 24). Processes, Vol. 12.

By: D. Raucher*, M. Rowsey*, J. Hinson*, I. Ćorković*, M. Lila n, J. Šimunović n, M. Kopjar*

author keywords: iridoids; anthocyanins; antiproliferative potential; tart cherry juice; cornelian cherry juice; blackthorn juice
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Natural product bioactivities and synthesis; Plant biochemistry and biosynthesis; Phytochemistry and Biological Activities; Nephrotoxicity and Medicinal Plants
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 1, 2024

2024 journal article

Colloidal and interfacial properties of spray dried pulse protein-blueberry polyphenol particles in model dispersion systems

Food Chemistry, 457, 140073.

By: Y. Lin n, N. Cheng n, Y. Jiang n, M. Grace n, M. Lila n, R. Hoskin n, H. Zheng n

author keywords: Protein-polyphenol interactions; Pulse protein; Food ingredients; Functionality
MeSH headings : Polyphenols / chemistry; Colloids / chemistry; Plant Proteins / chemistry; Cicer / chemistry; Spray Drying; Particle Size; Pisum sativum / chemistry; Pea Proteins / chemistry; Fruit / chemistry; Plant Extracts / chemistry
topics (OpenAlex): Microencapsulation and Drying Processes; Proteins in Food Systems; Food Chemistry and Fat Analysis
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: November 12, 2024

2024 article

Correction: Gut-derived wild blueberry phenolic acid metabolites modulate extrinsic cutaneous damage

Ivarsson, J., Bennett, A., Ferrara, F., Strauch, R., Vallese, A., Iorizzo, M., … Valacchi, G. (2024, January 1). Food & Function, Vol. 10.

By: J. Ivarsson n, A. Bennett n, F. Ferrara*, R. Strauch n, A. Vallese*, M. Iorizzo*, A. Pecorelli n, M. Lila n, G. Valacchi*

topics (OpenAlex): Bee Products Chemical Analysis; Transgenic Plants and Applications; Fungal Biology and Applications
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 14, 2024

2024 article

Feeding the Body Through the Skin: Ethosomes and Transethosomes as a New Topical Delivery System for Bioactive Compounds

Esposito, E., Pecorelli, A., Ferrara, F., Lila, M. A., & Valacchi, G. (2024, June 28). Annual Review of Food Science and Technology, Vol. 15, pp. 53–78.

By: E. Esposito*, A. Pecorelli*, F. Ferrara*, M. Lila n & G. Valacchi n

author keywords: skin; ethosome; transethosome; topical administration; transdermal delivery; inflammation
MeSH headings : Humans; Administration, Cutaneous; Animals; Skin / metabolism; Drug Delivery Systems; Skin Absorption
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Proteins in Food Systems; Bee Products Chemical Analysis
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: September 3, 2024

2024 journal article

Fermentation of American elderberry juice yields functional phytochemicals for spray dried protein–polyphenol ingredients

Food Research International, 201, 115536.

author keywords: Biotransformation; Fruit ingredients; Food powders; Phytochemicals
MeSH headings : Fermentation; Fruit and Vegetable Juices / analysis; Saccharomyces cerevisiae / metabolism; Polyphenols / analysis; Sambucus / chemistry; Phytochemicals / chemistry; Spray Drying; Phenols / analysis; Food Handling / methods; Fruit / chemistry; Pea Proteins / chemistry; Plant Proteins; Hydrogen-Ion Concentration
topics (OpenAlex): Microencapsulation and Drying Processes; Phytochemicals and Antioxidant Activities; Fermentation and Sensory Analysis
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: February 10, 2025

2024 journal article

Genotype and ripening method affect carotenoid content and bio-accessibility in banana

Food & Function, 15(7), 3433–3445.

By: B. Munoz n, M. Hayes n, P. Perkins-Veazie n, N. Gillitt, M. Munoz, C. Kay n, M. Lila n, M. Ferruzzi n, M. Iorizzo n

MeSH headings : Musa / genetics; Carotenoids; Biofortification; Fruit / genetics; Genotype; Ethylenes; Plant Proteins / genetics
topics (OpenAlex): Banana Cultivation and Research; Agricultural and Food Sciences
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: March 8, 2024

2024 article

Gut-derived wild blueberry phenolic acid metabolites modulate extrinsic cutaneous damage

Ivarsson, J., Bennett, A., Ferrara, F., Strauch, R., Vallase, A., Iorizzo, M., … Valacchi, G. (2024, January 1). Food & Function, Vol. 6.

By: J. Ivarsson n, A. Bennett n, F. Ferrara*, R. Strauch n, A. Vallase*, M. Iorizzo*, A. Pecorelli n, M. Lila n, G. Valacchi*

MeSH headings : Humans; Blueberry Plants / chemistry; Skin / metabolism; Skin / drug effects; Hydroxybenzoates / pharmacology; Ultraviolet Rays; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Coculture Techniques; Lipid Peroxidation / drug effects; Interleukin-8 / metabolism; Oxidative Stress / drug effects
topics (OpenAlex): Bee Products Chemical Analysis; Phytochemicals and Antioxidant Activities; Skin Protection and Aging
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 8, 2024

2024 article

Inference of the genetic basis of fruit texture in highbush blueberries using genome-wide association analyses

Ferrão, L. F. V., Azevedo, C., Benevenuto, J., Mengist, M. F., Luby, C., Pottorff, M., … Munoz, P. R. (2024, August 21). Horticulture Research, Vol. 11.

By: L. Ferrão*, C. Azevedo*, J. Benevenuto*, M. Mengist*, C. Luby n, M. Pottorff*, G. Casorzo*, T. Mackey* ...

topics (OpenAlex): Berry genetics and cultivation research; Horticultural and Viticultural Research; Powdery Mildew Fungal Diseases
Sources: Web Of Science, NC State University Libraries
Added: November 4, 2024

2024 article

Spray dried insect protein-polyphenol particles deliver health-relevant value-added food ingredients

Silva, E. S., Xiong, J., Medeiros, F. G. M., Grace, M., Moncada, M., Lila, M. A., & Hoskin, R. T. (2024, February 4). Future Foods, Vol. 9.

author keywords: Alternative protein; Cricket; Food ingredients; Revalorization
topics (OpenAlex): Microencapsulation and Drying Processes; Proteins in Food Systems; Bee Products Chemical Analysis
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2023 article

Blueberry Supplementation and Skin Health

Ivarsson, J., Pecorelli, A., Lila, M. A., & Valacchi, G. (2023, June 12). Antioxidants, Vol. 12.

By: J. Ivarsson n, A. Pecorelli*, M. Lila n & G. Valacchi n

author keywords: blueberries; skin; inflammation; polyphenol; antioxidant
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Skin Protection and Aging; Bee Products Chemical Analysis
TL;DR: The argument for blueberries to possibly be an effective agent for skin health is built and the need for further research to elucidate the mechanisms behind the use of both topical application and dietary supplementation with blueberry to bolster cutaneous systems and defensive mechanisms is highlighted. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 14, 2023

2023 article

Blueberry intake elevates post-exercise anti-inflammatory oxylipins: a randomized trial

Nieman, D. C., Sakaguchi, C. A., Omar, A. M., Davis, K. L., Shaffner, C. E., Strauch, R. C., … Zhang, Q. (2023, July 24). Scientific Reports.

By: D. Nieman*, C. Sakaguchi*, A. Omar*, K. Davis*, C. Shaffner*, R. Strauch n, M. Lila n, Q. Zhang*

MeSH headings : Adult; Humans; Oxylipins; Anthocyanins; Blueberry Plants; Myalgia; Anti-Inflammatory Agents; Docosahexaenoic Acids; Eicosapentaenoic Acid
topics (OpenAlex): Eicosanoids and Hypertension Pharmacology; Pharmacology and Obesity Treatment; Exercise and Physiological Responses
Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023

2023 article

Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries

Weaver, C. M., Ferruzzi, M. G., Maiz, M., Cladis, D. P., Nakatsu, C. H., McCabe, G. P., & Lila, M. A. (2023, May 22). Antioxidants, Vol. 12.

By: C. Weaver*, M. Ferruzzi*, M. Maiz*, D. Cladis*, C. Nakatsu*, G. McCabe*, M. Lila n

author keywords: blueberries; polyphenols; anthocyanins; precision nutrition
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Nutrition, Genetics, and Disease; Consumer Attitudes and Food Labeling
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 24, 2023

2023 article

Development of Spray Dried Spirulina Protein-Berry Pomace Polyphenol Particles to Attenuate Pollution-Induced Skin Damage: A Convergent Food-Beauty Approach

Hoskin, R. T., Grace, M. H., Guiotto, A., Pecorelli, A., Valacchi, G., & Lila, M. A. (2023, July 15). Antioxidants, Vol. 12.

By: R. Hoskin n, M. Grace n, A. Guiotto n, A. Pecorelli n, G. Valacchi n & M. Lila n

author keywords: sustainability; value-added; repurposing; skin health; cosmeceuticals
topics (OpenAlex): Microencapsulation and Drying Processes; Bee Products Chemical Analysis; Phytochemicals and Antioxidant Activities
TL;DR: It is demonstrated that protein-polyphenol complexation is a synergistic strategy to stabilize and deliver residual fruit/algae phytoactives into cosmeceutical products for skin health applications. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 17, 2023

2023 article

Evaluation of saffron extract bioactivities relevant to skin resilience

Xiong, J., Grace, M. H., Kobayashi, H., & Lila, M. A. (2023, January 13). Journal of Herbal Medicine, Vol. 37.

By: J. Xiong n, M. Grace n, H. Kobayashi* & M. Lila n

author keywords: Tyrosinase; Collagenase; Collagen; Hyaluronic acid; Antioxidant activity; Crocus sativus
topics (OpenAlex): Saffron Plant Research Studies; melanin and skin pigmentation; Phytochemical and Pharmacological Studies
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 14, 2023

2023 article

Influence of 2 Weeks of Mango Ingestion on Inflammation Resolution after Vigorous Exercise

Sakaguchi, C. A., Nieman, D. C., Omar, A. M., Strauch, R. C., Williams, J. C., Lila, M. A., & Zhang, Q. (2023, December 21). Nutrients, Vol. 16.

author keywords: mangoes; exercise; inflammation; metabolites; gallotannins; oxylipins; tandem mass spectrometry
MeSH headings : Cross-Over Studies; Eating; Inflammation; Mangifera; Oxylipins; Phenols; Water; Humans; Exercise
topics (OpenAlex): High Altitude and Hypoxia; Mangiferin and Mango Extracts; Eicosanoids and Hypertension Pharmacology
TL;DR: The 2.25 h cycling bouts induced significant inflammation, but no countermeasure effect was found after 2 weeks of mango ingestion despite the elevation of mango gut-derived phenolic metabolites. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 26, 2024

2023 article

Influence of 2-Weeks Mango Ingestion on Inflammation Resolution After Vigorous Exercise

Sakaguchi, C. A., Nieman, D. C., Omar, A. M., Strauch, R. C., Williams, J. C., & Lila, M. A. (2023, November 29). Preprints.org.

By: C. Sakaguchi*, D. Nieman*, A. Omar*, R. Strauch n, J. Williams* & M. Lila n

topics (OpenAlex): Exercise and Physiological Responses; Mangiferin and Mango Extracts
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: January 26, 2024

2023 article

Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial

Hodges, J. K., Maiz, M., Cao, S., Lachcik, P. J., Peacock, M., McCabe, G. P., … Weaver, C. M. (2023, June 1). American Journal of Clinical Nutrition, Vol. 118, pp. 382–390.

By: J. Hodges*, M. Maiz*, S. Cao*, P. Lachcik*, M. Peacock*, G. McCabe*, L. McCabe*, D. Cladis* ...

author keywords: bone; blueberries; calcium; osteoporosis; polyphenols; postmenopausal
MeSH headings : Female; Humans; Rats; Animals; Calcium / urine; Blueberry Plants; Powders; Postmenopause; Cross-Over Studies; Bone Resorption / prevention & control; Biomarkers; Osteoporosis, Postmenopausal / prevention & control
topics (OpenAlex): Nutrition, Genetics, and Disease; Phytoestrogen effects and research; Phytochemicals and Antioxidant Activities
TL;DR: Moderate consumption of blueberries may be an effective strategy to attenuate bone loss in healthy postmenopausal women and no significant relationships were found between bone resorption biomarkers, 25-hydroxyvitamin D, and interventions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2023 article

Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson’s Disease

Tambe, M. A., Rus Jacquet, A., Strathearn, K. E., Hensel, J. A., Colón, B. D., Chandran, A., … Rochet, J.-C. (2023, July 20). Antioxidants, Vol. 12.

By: M. Tambe*, A. Rus Jacquet*, K. Strathearn*, J. Hensel*, B. Colón*, A. Chandran*, G. Yousef n, M. Grace n ...

author keywords: anthocyanin; Nrf2; paraquat; Parkinson's disease; polyphenols; rotenone
topics (OpenAlex): Parkinson's Disease Mechanisms and Treatments; Phytochemicals and Antioxidant Activities; Biochemical and biochemical processes
TL;DR: It is suggested that extracts enriched with certain combinations of ANC, PAC, stilbenes, and other polyphenols could potentially slow neurodegeneration in the brains of individuals exposed to PQ or rotenone by activating cellular antioxidant mechanisms and/or alleviating mitochondrial dysfunction. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 25, 2023

2023 journal article

Spray drying to produce novel phytochemical-rich ingredients from juice and pomace of American elderberry

Food Bioscience, 55, 102981.

author keywords: Sambucus; Dietary supplement; Repurposing; Powder ingredients; Bioaccessibility; Phytochemicals
topics (OpenAlex): Microencapsulation and Drying Processes; Phytochemicals and Antioxidant Activities; Proteins in Food Systems
Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 18, 2023

2023 article

Spray‐drying microencapsulation of blackcurrant and cocoa polyphenols using underexplored plant‐based protein sources

Hoskin, R. T., Grace, M. H., Xiong, J., & Lila, M. A. (2023, May 9). Journal of Food Science, Vol. 5.

By: R. Hoskin n, M. Grace n, J. Xiong n & M. Lila n

author keywords: buckwheat; chia; pea; protein; carriers; revalorization
MeSH headings : Polyphenols / chemistry; Plant Proteins / chemistry; Antioxidants / chemistry; Anthocyanins; Chocolate; Pea Proteins; Plant Extracts / chemistry; Cacao / chemistry; Phytochemicals
topics (OpenAlex): Microencapsulation and Drying Processes; Proteins in Food Systems; Phytochemicals and Antioxidant Activities
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 11, 2023

2022 journal article

Autopolyploid inheritance and a heterozygous reciprocal translocation shape chromosome genetic behavior in tetraploid blueberry (Vaccinium corymbosum)

New Phytologist, 237(3), 1024–1039.

author keywords: autopolyploid; blueberry (Vaccinium corymbosum L; ); centromeric repeat; chromosomal translocation; chromosome structure; phased genome; polyploid genetic behavior
MeSH headings : Tetraploidy; Blueberry Plants / genetics; Inheritance Patterns; Polyploidy; Chromosomes
topics (OpenAlex): Berry genetics and cultivation research; Plant tissue culture and regeneration; Plant Virus Research Studies
TL;DR: A new high‐quality, phased, chromosome‐scale genome of a diploid blueberry, clone W85 is described, which will facilitate new genetic and comparative genomic studies in Vaccinium and the development of genomic assisted selection strategy for this crop. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: September 4, 2022

2022 journal article

Bioaccessibility and intestinal cell uptake of carotenoids and chlorophylls differ in powdered spinach by the ingredient form as measured using in vitro gastrointestinal digestion and anaerobic fecal fermentation models

Food & Function, 13(7), 3825–3839.

By: M. Hayes n, Z. Mohamedshah n, S. Chadwick-Corbin n, R. Hoskin n, M. Iorizzo n, M. Lila n, A. Neilson n, M. Ferruzzi n

MeSH headings : Anaerobiosis; Caco-2 Cells; Carotenoids / metabolism; Chlorophyll; Digestion; Fermentation; Health Promotion; Humans; Powders; Spinacia oleracea / metabolism
topics (OpenAlex): Nutritional Studies and Diet; Food composition and properties; Microbial Metabolites in Food Biotechnology
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: March 31, 2022

2022 article

Boosting the Bioaccessibility of Dietary Bioactives by Delivery as Protein–Polyphenol Aggregate Particles

Lila, M. A., Hoskin, R. T., Grace, M. H., Xiong, J., Strauch, R., Ferruzzi, M., … Kay, C. (2022, April 8). Journal of Agricultural and Food Chemistry, Vol. 4.

By: M. Lila n, R. Hoskin n, M. Grace n, J. Xiong n, R. Strauch n, M. Ferruzzi*, M. Iorizzo n, C. Kay n

author keywords: bioavailability; digestion; absorption; circulation; uptake; matrix
MeSH headings : Humans; Polyphenols / analysis; Fruit / chemistry; Protein Aggregates; Dietary Proteins; Biological Availability; Food Ingredients
topics (OpenAlex): Proteins in Food Systems; Protein Hydrolysis and Bioactive Peptides; Microbial Metabolites in Food Biotechnology
TL;DR: Evidence to date suggests that complexation of phy toactive polyphenolics effectively enhances their health-relevant impacts, specifically because the phytoactives are protected in the protein matrix during transit in the GIT, allowing intact, non-degraded molecules to reach the colon for catabolism at the gut microbiome level. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 14, 2022

2022 article

Continuous flow microwave-assisted aqueous extraction of pomace phytoactives for production of protein-polyphenol particles and a protein-enriched ready-to-drink beverage

Hoskin, R. T., Plundrich, N., Vargochik, A., & Lila, M. A. (2022, March 3). Future Foods, Vol. 5, p. 100137.

By: R. Hoskin n, N. Plundrich, A. Vargochik & M. Lila n

topics (OpenAlex): Microencapsulation and Drying Processes; Phytochemicals and Antioxidant Activities; Proteins in Food Systems
Source: ORCID
Added: March 4, 2022

2022 article

Dissecting the genetic basis of bioactive metabolites and fruit quality traits in blueberries (Vaccinium corymbosum L.)

Mengist, M. F., Grace, M. H., Mackey, T., Munoz, B., Pucker, B., Bassil, N., … Iorizzo, M. (2022, September 2). Frontiers in Plant Science, Vol. 13.

By: M. Mengist n, M. Grace n, T. Mackey*, B. Munoz n, B. Pucker*, N. Bassil*, C. Luby*, M. Ferruzzi n, M. Lila n, M. Iorizzo n

author keywords: blueberry; anthocyanin; acylation; glycosylation; QTL mapping; candidate genes; fruit quality; chlorogenic acid
topics (OpenAlex): Plant Gene Expression Analysis; Phytochemicals and Antioxidant Activities; Plant biochemistry and biosynthesis
TL;DR: The study provides the first insights into the genetic basis controlling anthocyanins accumulation and composition, chlorogenic acid and fruit quality traits, and establishes a framework to advance genetic studies and molecular breeding for anthcyanins in blueberry. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022

2022 journal article

Enhancing the Cognitive Effects of Flavonoids With Physical Activity: Is There a Case for the Gut Microbiome?

Frontiers in Neuroscience, 16.

By: C. Cheatham*, D. Nieman*, A. Neilson n & M. Lila n

author keywords: age-related; cognition; neuroprotective; phenolic metabolites; prebiotic flavonoids; exercise; microbiome
topics (OpenAlex): Gut microbiota and health; Tryptophan and brain disorders; Dietary Effects on Health
TL;DR: There is a potential for combined impacts of flavonoids intake and physical exertion on cognitive function, as modulated by the gut microbiome, and that the combination of a flavonoid-rich diet and routine aerobic exercise may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the Gut microbiome. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: March 28, 2022

2022 article

Erratum to “Continuous flow microwave-assisted aqueous extraction of pomace phytoactives for production of protein-polyphenol particles and a protein-enriched ready-to-drink beverage” [Future Foods, 5 (2021) 100137]

Hoskin, R. T., Plundrich, N., Vargochik, A., & Lila, M. A. (2022, June 27). Future Foods.

By: R. Hoskin n, N. Plundrich, A. Vargochik & M. Lila n

topics (OpenAlex): Food Industry and Aquatic Biology; Protein Hydrolysis and Bioactive Peptides
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 6, 2023

2022 article

Protein‐binding approaches for improving bioaccessibility and bioavailability of anthocyanins

Wu, H., Oliveira, G., & Lila, M. A. (2022, November 18). Comprehensive Reviews in Food Science and Food Safety, Vol. 11.

By: H. Wu*, G. Oliveira* & M. Lila n

author keywords: anthocyanin-protein complexes; bioavailability; digestibility; gastrointestinal; pigments
MeSH headings : Animals; Humans; Anthocyanins / chemistry; Biological Availability; Protein Binding; Food
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Biochemical Analysis and Sensing Techniques; Proteins in Food Systems
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UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 19, 2022

2022 article

Six-month intervention with wild blueberries improved speed of processing in mild cognitive decline: a double-blind, placebo-controlled, randomized clinical trial.

Cheatham, C. L., Canipe, L. G., Millsap, G., Stegall, J. M., Chai, S. C., Sheppard, K. W., & Lila, M. A. (2022, September 6). Nutritional Neuroscience, Vol. 9.

By: C. Cheatham*, L. Canipe*, G. Millsap*, J. Stegall*, S. Chai*, K. Sheppard*, M. Lila n

author keywords: aging; CANTAB; event-related potentials; flavonoids; mild cognitive decline; speed of processing; polyphenols; wild blueberries
topics (OpenAlex): Medicinal Plants and Neuroprotection
TL;DR: Consumption of wild blueberries for six months improves cognitive aging sequelae by improving the speed of information processing in older adults by restoring speed of processing to the level of the reference group. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 19, 2022

2022 article

Spray-dried and freeze-dried protein-spinach particles; effect of drying technique and protein type on the bioaccessibility of carotenoids, chlorophylls, and phenolics

Grace, M. H., Hoskin, R. T., Hayes, M., Iorizzo, M., Kay, C., Ferruzzi, M. G., & Lila, M. A. (2022, April 20). Food Chemistry, Vol. 388.

By: M. Grace n, R. Hoskin n, M. Hayes n, M. Iorizzo n, C. Kay n, M. Ferruzzi n, M. Lila n

author keywords: Spinach phytochemicals; Whey protein; Soy protein; Drying; In vitro digestion; Dried ingredients
MeSH headings : Carotenoids / metabolism; Chlorophyll / metabolism; Digestion; Excipients / metabolism; Flavonoids / metabolism; Freeze Drying; Phenols / metabolism; Spinacia oleracea / metabolism
topics (OpenAlex): Microencapsulation and Drying Processes; Proteins in Food Systems; Protein Hydrolysis and Bioactive Peptides
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: June 13, 2022

2022 journal article

There and back again; historical perspective and future directions for Vaccinium breeding and research studies

Horticulture Research, 9.

topics (OpenAlex): Horticultural and Viticultural Research; Berry genetics and cultivation research; Plant Physiology and Cultivation Studies
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 1, 2022

2021 article

Alaskan Bog Blueberry (Vaccinium uliginosum) Extract as an Innovative Topical Approach to Prevent UV-Induced Skin Damage

Pambianchi, E., Hagenberg, Z., Pecorelli, A., Grace, M., Therrien, J.-P., Lila, M. A., & Valacchi, G. (2021, November 27). Cosmetics, Vol. 12.

By: E. Pambianchi n, Z. Hagenberg n, A. Pecorelli n, M. Grace n, J. Therrien n, M. Lila n, G. Valacchi n

author keywords: cosmeceuticals; environmental stressor; oxidation; inflammation; antioxidant; OxInflammation; phytochemicals
topics (OpenAlex): Skin Protection and Aging; Dermatology and Skin Diseases; Phytochemicals and Antioxidant Activities
TL;DR: It is observed that the topical application of BB extract on human ex vivo skin explants averted the UV-induced cutaneous OxInflammatory phenomenon by quenching the increase in the oxidative and inflammatory marker levels. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 2, 2021

2021 article

Cutaneous antimicrobial peptides: New “actors” in pollution related inflammatory conditions

Woodby, B., Pambianchi, E., Ferrara, F., Therrien, J.-P., Pecorelli, A., Messano, N., … Valacchi, G. (2021, March 31). Redox Biology, Vol. 41, p. 101952.

By: B. Woodby, E. Pambianchi, F. Ferrara*, J. Therrien, A. Pecorelli, N. Messano, M. Lila*, G. Valacchi*

author keywords: Skin; LL37; ROS; Antimicrobial peptides; Pollution
MeSH headings : Humans; Hydrogen Peroxide; Keratinocytes; Pore Forming Cytotoxic Proteins; Skin; Skin Diseases
topics (OpenAlex): Antimicrobial Peptides and Activities; Skin Protection and Aging; Asthma and respiratory diseases
TL;DR: Exposure to O3 is hypothesized to contribute to various cutaneous inflammatory conditions, such as eczema, psoriasis, rush etc via a redox-inflammatory pathway and altered levels of AMPs are observed, suggesting that targeting AMPs could be a possible defensive strategy to combat pollution-associated skin conditions. (via Semantic Scholar)
Source: ORCID
Added: April 1, 2021

2021 article

Efficacy of Pecan Husk and Shell Phenolic Extracts Against Phytophthora Blight in Chile Pepper

Lujan, P., Dura, S., Guzman, I., Grace, M., Lila, M. A., Steiner, R., & Sanogo, S. (2021, January 1). Plant Health Progress.

author keywords: Phytophthora capsici; Capsicum annuum; induced resistance; elicitors; proanthocyanidins; soilborne pathogens
topics (OpenAlex): Plant Pathogens and Resistance; Plant-Microbe Interactions and Immunity; Plant Pathogens and Fungal Diseases
TL;DR: Pecan byproducts may be used as additional options for management of Phytophthora blight and the phenolic content in the extracts was largely made up of proanthocyanidins also known as condensed tannins. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 18, 2022

2021 article

Foaming and sensory characteristics of protein-polyphenol particles in a food matrix

Diaz, J. T., Foegeding, E. A., Stapleton, L., Kay, C., Iorizzo, M., Ferruzzi, M. G., & Lila, M. A. (2021, August 25). Food Hydrocolloids.

By: J. Diaz n, E. Foegeding n, L. Stapleton, C. Kay n, M. Iorizzo n, M. Ferruzzi n, M. Lila n

author keywords: Particles; Polyphenols; Proteins; Foaming; Sensory; Structure
topics (OpenAlex): Proteins in Food Systems; Pickering emulsions and particle stabilization; Microencapsulation and Drying Processes
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UN Sustainable Development Goal Categories
Source: ORCID
Added: August 26, 2021

2021 article

Gains and Losses of Agricultural Food Production: Implications for the Twenty-First Century

Komarnytsky, S., Retchin, S., Vong, C. I., & Lila, M. A. (2021, November 23). Annual Review of Food Science and Technology.

By: S. Komarnytsky n, S. Retchin*, C. Vong n & M. Lila n

author keywords: agricultural food systems; genetic improvement; biofortification; phytochemicals; alternative proteins; sustainable agriculture
MeSH headings : Agriculture; Animals; Biodiversity; Climate Change; Crops, Agricultural; Food Supply
topics (OpenAlex): Agriculture Sustainability and Environmental Impact; Seed and Plant Biochemistry; Food Waste Reduction and Sustainability
TL;DR: This review introduces the concept of agricultural food systems losses and focuses on improved sources of agricultural diversity, proteins with enhanced resilience, and novel monitoring, processing, and distribution technologies that are poised to improve food security, reduce food loss and waste, and improve health profiles in the near future. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science; OpenAlex)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 23, 2022

2021 journal article

High-density linkage map construction and identification of loci regulating fruit quality traits in blueberry

Horticulture Research, 8(1).

By: M. Mengist n, H. Bostan n, E. Young n, K. Kay*, N. Gillitt*, J. Ballington n, C. Kay n, M. Ferruzzi n ...

topics (OpenAlex): Berry genetics and cultivation research; Horticultural and Viticultural Research; Plant Physiology and Cultivation Studies
TL;DR: The genetic basis of fruit quality traits in blueberry was dissected and an association between these fruit quality trait and metabolites detected by Proton nuclear magnetic resonance analysis was established. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 1, 2021

2021 article

Influence of simulated food and oral processing on carotenoid and chlorophyll in vitro bioaccessibility among six spinach genotypes

Hayes, M., Corbin, S., Nunn, C., Pottorff, M., Kay, C. D., Lila, M. A., … Ferruzzi, M. G. (2021, January 1). Food & Function, Vol. 5.

By: M. Hayes n, S. Corbin*, C. Nunn*, M. Pottorff*, C. Kay n, M. Lila n, M. Iorrizo n, M. Ferruzzi n

MeSH headings : Biological Availability; Carotenoids / chemistry; Carotenoids / metabolism; Carotenoids / pharmacokinetics; Chlorophyll / chemistry; Chlorophyll / metabolism; Chlorophyll / pharmacokinetics; Digestion; Genotype; Models, Biological; Spinacia oleracea / chemistry; Spinacia oleracea / genetics
topics (OpenAlex): Consumer Attitudes and Food Labeling; Seed and Plant Biochemistry; Food Science and Nutritional Studies; Antioxidant Activity and Oxidative Stress; Pomegranate: compositions and health benefits
TL;DR: It is suggested that the genotype, processing treatment, and genotype × processing (G × P) interaction may affect carotenoid and chlorophyll bioaccessibility in spinach and that food processing remains a dominant factor in modulating the bioavailability of these phytochemicals. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 22, 2021

2021 article

Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models

Rus Jacquet, A., Ambaw, A., Tambe, M. A., Ma, S. Y., Timmers, M., Grace, M. H., … Rochet, J.-C. (2021, January 1). Food & Function, Vol. 7.

By: A. Rus Jacquet*, A. Ambaw*, M. Tambe*, S. Ma*, M. Timmers n, M. Grace n, Q. Wu*, J. Simon* ...

MeSH headings : Animals; Astrocytes / drug effects; Cells, Cultured; Dietary Supplements; Dopaminergic Neurons / drug effects; Female; Humans; Isoflavones / pharmacology; Male; Models, Biological; Neuroprotective Agents / pharmacology; Parkinson Disease / metabolism; Phytochemicals / pharmacology; Rats; Rats, Sprague-Dawley; Soybeans / chemistry; Trifolium / chemistry
topics (OpenAlex): Phytoestrogen effects and research; Biochemical effects in animals; Coenzyme Q10 studies and effects
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 10, 2021

2021 article

Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage

Hoskin, R., Pambianchi, E., Pecorelli, A., Grace, M., Therrien, J.-P., Valacchi, G., & Lila, M. A. (2021, June 22). Molecules, Vol. 7, p. 3781.

By: R. Hoskin n, E. Pambianchi n, A. Pecorelli n, M. Grace n, J. Therrien*, G. Valacchi n, M. Lila n

author keywords: cosmeceuticals; pollution; phytochemicals; herbs
MeSH headings : Antioxidants / chemistry; Antioxidants / pharmacology; Cells, Cultured; Chlorella / chemistry; Cinnamates / chemistry; Depsides / chemistry; Environmental Exposure / adverse effects; Filaggrin Proteins; Humans; Rosmarinus / chemistry; Skin / injuries; Skin / metabolism; Skin / pathology; Skin Aging / drug effects
topics (OpenAlex): Skin Protection and Aging; Bee Products Chemical Analysis; Phytochemicals and Antioxidant Activities
TL;DR: The ex-vivo data clearly demonstrated the ability of RSP gel to prevent an oxinflammatory phenomenon in cutaneous tissue by decreasing the levels of 4-hydroxynonenal protein adducts and active matrix metalloproteinase-9 (MMP-9) by limiting the loss of filaggrin induced by DEE exposure. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 23, 2021

2021 article

Pea protein isolate characteristics modulate functional properties of pea protein–cranberry polyphenol particles

Strauch, R. C., & Lila, M. A. (2021, May 24). Food Science & Nutrition, Vol. 5.

By: R. Strauch n & M. Lila n

author keywords: by-products; cranberry polyphenols; digestion; pea protein isolate; solubility
topics (OpenAlex): Proteins in Food Systems; Phytase and its Applications; Protein Hydrolysis and Bioactive Peptides
TL;DR: Plant polyphenols have a natural binding affinity for proteins, and their interaction can be exploited to form diverse aggregate particles to allow consumers to incorporate more health‐benefiting plant bioactives into their diets. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 25, 2021

2021 article

Phytoecdysteroids Do Not Have Anabolic Effects in Skeletal Muscle in Sedentary Aging Mice

Lawrence, M. M., Zwetsloot, K. A., Arthur, S. T., Sherman, C. A., Huot, J. R., Badmaev, V., … Shanely, R. A. (2021, January 6). International Journal of Environmental Research and Public Health, Vol. 18.

By: M. Lawrence*, K. Zwetsloot*, S. Arthur*, C. Sherman*, J. Huot*, V. Badmaev*, M. Grace n, M. Lila n, D. Nieman*, R. Shanely*

author keywords: skeletal muscle; hypertrophy; Akt; atrogenes; 20-hydroxyecdysone
MeSH headings : Aging; Anabolic Agents; Animals; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Rats
topics (OpenAlex): Neurobiology and Insect Physiology Research; Muscle Physiology and Disorders; Muscle metabolism and nutrition
TL;DR: Data indicate that phytoecdysteroid treatment does not alter muscle mass or fiber type, nor does it activate protein synthesis signaling in the skeletal muscle of sedentary aging mice. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 7, 2021

2021 article

The berry health tool chest – an evidence map and interactive resource

Kay, K. L., Strauch, R. C., Granillo, C. D., Bame, M. W., Xiong, J., Mast, A. C., … Lila, M. A. (2021, February 19). Nutrition Reviews.

By: K. Kay n, R. Strauch n, C. Granillo n, M. Bame n, J. Xiong n, A. Mast n, B. Burton-Freeman*, C. Kay n, M. Lila n

author keywords: berry; clinical trial design; dietary intervention; evidence mapping; health criteria
MeSH headings : Eating; Fruit; Humans
topics (OpenAlex): Obesity, Physical Activity, Diet; Nutritional Studies and Diet; Consumer Attitudes and Food Labeling
TL;DR: The development and utility of the "Berry Health Tool Chest," an evidence map summarizing trial design features of studies characterizing the impact of berry consumption upon human health biomarkers, are described. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2022

2021 article

Whey and soy proteins as wall materials for spray drying rosemary: Effects on polyphenol composition, antioxidant activity, bioaccessibility after in vitro gastrointestinal digestion and stability during storage

Grace, M. H., Hoskin, R., Xiong, J., & Lila, M. A. (2021, June 11). LWT, Vol. 9, p. 111901.

By: M. Grace n, R. Hoskin n, J. Xiong n & M. Lila n

author keywords: Protein-polyphenol; Phenolic diterpenes; Bioaccessibility; Rosemary antioxidants; Spray-drying
topics (OpenAlex): Microencapsulation and Drying Processes; Proteins in Food Systems; Botanical Research and Applications
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 16, 2021

2020 article

Blueberry Extracts as a Novel Approach to Prevent Ozone-Induced Cutaneous Inflammasome Activation

Pambianchi, E., Ferrara, F., Pecorelli, A., Woodby, B., Grace, M., Therrien, J.-P., … Valacchi, G. (2020, August 14). Oxidative Medicine and Cellular Longevity.

By: E. Pambianchi*, F. Ferrara*, A. Pecorelli*, B. Woodby*, M. Grace, J. Therrien, M. Lila*, G. Valacchi*

MeSH headings : Biopsy; Blueberry Plants / chemistry; Cell Death / drug effects; Cell Movement / drug effects; Cell Proliferation / drug effects; HaCaT Cells; Humans; Hydrogen Peroxide / metabolism; Inflammasomes / metabolism; Keratinocytes / drug effects; Keratinocytes / pathology; Models, Biological; Oxidative Stress / drug effects; Ozone / toxicity; Plant Extracts / pharmacology; Protein Multimerization / drug effects; Skin / drug effects; Skin / pathology
topics (OpenAlex): Inflammasome and immune disorders; Medical and Biological Ozone Research; Heme Oxygenase-1 and Carbon Monoxide
TL;DR: The hypothesis that blueberry (BB) extract can effectively reduce skin inflammation and be a possible new technology against cutaneous pollution-induced damage is supported. (via Semantic Scholar)
Source: ORCID
Added: August 15, 2020

2020 article

Blueberry and/or Banana Consumption Mitigate Arachidonic, Cytochrome P450 Oxylipin Generation During Recovery From 75-Km Cycling: A Randomized Trial

Nieman, D. C., Gillitt, N. D., Chen, G.-Y., Zhang, Q., Sha, W., Kay, C. D., … Lila, M. A. (2020, August 7). Frontiers in Nutrition, Vol. 7.

By: D. Nieman*, N. Gillitt*, G. Chen*, Q. Zhang*, W. Sha*, C. Kay n, P. Chandra n, K. Kay*, M. Lila n

author keywords: exercise; lipid mediators; carbohydrate; polyphenols; metabolites; inflammation; fatty acids
topics (OpenAlex): Eicosanoids and Hypertension Pharmacology; Alcohol Consumption and Health Effects; Muscle metabolism and nutrition
TL;DR: Heavy exertion evoked a transient but robust increase in plasma levels of oxylipins in cyclists, with a strong attenuation effect linked to both chronic blueberry and acute banana intake on pro-inflammatory ARA-CYP oxylIPins. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 21, 2020

2020 article

Building a Resilient, Sustainable, and Healthier Food Supply Through Innovation and Technology

McClements, D. J., Barrangou, R., Hill, C., Kokini, J. L., Lila, M. A., Meyer, A. S., & Yu, L. (2020, December 22). Annual Review of Food Science and Technology, Vol. 12, pp. 1–28.

By: D. McClements*, R. Barrangou n, C. Hill*, J. Kokini*, M. Lila n, A. Meyer*, L. Yu*

author keywords: future foods; food production; food processing; environmental impacts; nanotechnology; gene editing; genetic engineering; artificial intelligence; robotics
MeSH headings : Agriculture; Artificial Intelligence; Biotechnology; COVID-19; Food Quality; Food Safety; Food Supply / standards; Humans; Nanotechnology; Pandemics; Robotics
topics (OpenAlex): Food Waste Reduction and Sustainability; Agriculture Sustainability and Environmental Impact; Consumer Attitudes and Food Labeling
TL;DR: A perspective article, written by members of the Editorial Committee of the Annual Review of Food Science and Technology, highlights some of the major challenges confronting the modern food supply chain as well as how innovations in policy and technology can be used to address them. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 24, 2021

2020 article

Chemical Composition and Bioactive Properties of Commercial and Non-Commercial Purple and White Açaí Berries

Matta, F. V., Xiong, J., Lila, M. A., Ward, N. I., Felipe-Sotelo, M., & Esposito, D. (2020, September 29). Preprints.org, Vol. 9.

topics (OpenAlex): Phytochemicals and Antioxidant Activities; Pomegranate: compositions and health benefits; Psidium guajava Extracts and Applications
Source: ORCID
Added: October 1, 2020

2020 article

Chemical Composition and Bioactive Properties of Commercial and Non-Commercial Purple and White Açaí Berries

Matta, F. V., Xiong, J., Lila, M. A., Ward, N. I., Felipe-Sotelo, M., & Esposito, D. (2020, October 16). Foods, Vol. 9, p. 1481.

author keywords: acai; total polyphenol; total anthocyanin; antioxidant; elemental analysis; essential elements; biological activity; wound healing
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Antioxidant Activity and Oxidative Stress; Plant biochemistry and biosynthesis
TL;DR: All the açaí samples demonstrated potential as wound healing agents due to the high levels of migration activity in human fibroblast cells, and presented significant levels of calcium, magnesium, manganese, iron, zinc and copper, essential minor and trace elements, in comparison with other berries. (via Semantic Scholar)
Source: ORCID
Added: October 23, 2020

2020 article

Development of a genetic framework to improve the efficiency of bioactive delivery from blueberry

Mengist, M. F., Burtch, H., Debelo, H., Pottorff, M., Bostan, H., Nunn, C., … Iorizzo, M. (2020, October 14). Scientific Reports, Vol. 10.

By: M. Mengist n, H. Burtch n, H. Debelo n, M. Pottorff n, H. Bostan n, C. Nunn n, S. Corbin n, C. Kay n ...

MeSH headings : Blueberry Plants / genetics; Blueberry Plants / metabolism; Digestion; Flavonoids / metabolism; Genotype; Hydroxybenzoates / metabolism; In Vitro Techniques
topics (OpenAlex): Horticultural and Viticultural Research; Phytochemicals and Antioxidant Activities; Berry genetics and cultivation research
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 16, 2020

2020 article

Enhanced stability of berry pomace polyphenols delivered in protein-polyphenol aggregate particles to an in vitro gastrointestinal digestion model

Xiong, J., Chan, Y. H., Rathinasabapathy, T., Grace, M. H., Komarnytsky, S., & Lila, M. A. (2020, June 12). Food Chemistry, Vol. 331, p. 127279.

By: J. Xiong n, Y. Chan n, T. Rathinasabapathy n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: J. Xiong n, Y. Chan n, T. Rathinasabapathy, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: Food matrix; By-product; Stability; Antioxidant; Anti-inflammatory
MeSH headings : Animals; Anthocyanins / analysis; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Antioxidants / analysis; Blueberry Plants / chemistry; Digestion; Food-Processing Industry; Fruit / chemistry; Mice; Plant Extracts / chemistry; Plant Extracts / pharmacokinetics; Plant Proteins, Dietary / chemistry; Polyphenols / pharmacokinetics; Proanthocyanidins / analysis; RAW 264.7 Cells; Vitis / chemistry
topics (OpenAlex): Proteins in Food Systems; Food composition and properties; Microencapsulation and Drying Processes
TL;DR: Protein-polyphenol particle digests retained 1.5 to 2-fold higher antioxidant capacity and suppressed the expression of pro-inflammatory cytokines, iNOS, IL6, and IL1β, compared to unmodified extract digests, which only suppressed IL6. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Source: ORCID
Added: June 19, 2020

2020 article

Formulation of protein–polyphenol particles for applications in food systems

Diaz, J. T., Foegeding, E. A., & Lila, M. A. (2020, January 1). Food & Function.

By: J. Diaz n, E. Foegeding n & M. Lila n

MeSH headings : Blueberry Plants / chemistry; Chemical Phenomena; Fruit / chemistry; Fruit and Vegetable Juices; Functional Food; Oryza; Particle Size; Plant Proteins, Dietary / chemistry; Polyphenols / chemistry; Vaccinium macrocarpon / chemistry; Whey Proteins / chemistry
topics (OpenAlex): Transgenic Plants and Applications; Proteins in Food Systems; Food Science and Nutritional Studies
TL;DR: Particles formed with whey protein and blueberry juice significantly improved foam stability and drainage half-life and protein-polyphenol particles can be designed as ingredients to stabilize food structures and to increase delivery of health protective polyphenols and proteins in the diet. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: May 30, 2020

2020 article

Hypoglycaemic, insulin releasing, and hepatoprotective effect of the aqueous extract of Aloe perryi Baker resin (Socotran Aloe) in streptozotocin-induced diabetic rats

Aldayel, T. S., Alshammari, G. M., Omar, U. M., Grace, M. H., Lila, M. A., & Yahya, M. A. (2020, January 1). Journal of Taibah University for Science.

author keywords: Aloe perryi; polyphenols; anti-diabetic; anti-hyperlipidemia; ALT; AST
topics (OpenAlex): Phytochemistry and biological activity of medicinal plants; Natural Antidiabetic Agents Studies; Phytochemicals and Antioxidant Activities
TL;DR: In conclusion, AP extract exerts hypoglycaemic, insulin-releasing, and hepatic antioxidant potentials in diabetic rats. (via Semantic Scholar)
Source: ORCID
Added: December 13, 2020

2020 article

In Vitro Bioaccessibility of Carotenoids and Chlorophylls in a Diverse Collection of Spinach Accessions and Commercial Cultivars

Hayes, M., Pottorff, M., Kay, C., Deynze, A. V., Osorio-Marin, J., Lila, M. A., … Ferruzzi, M. G. (2020, March 3). Journal of Agricultural and Food Chemistry, Vol. 68, pp. 3495–3505.

By: M. Hayes n, M. Pottorff n, C. Kay n, A. Deynze*, J. Osorio-Marin*, M. Lila n, M. Iorrizo n, M. Ferruzzi n

author keywords: spinach; carotenoids; lutein; beta-carotene; chlorophyll; genotypes; bioaccessibility; in vitro digestion
MeSH headings : Carotenoids; Chlorophyll; Chlorophyll A; Spinacia oleracea / genetics; beta Carotene
topics (OpenAlex): Antioxidant Activity and Oxidative Stress; Plant Physiology and Cultivation Studies; Phytochemicals and Antioxidant Activities
TL;DR: The results suggest that carotenoid and chlorophyll bioaccessible contents may vary based on spinach genotypes and may be stable across seasons. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 8, 2020

2020 article

LC-MS characterization of bioactive metabolites from two Yemeni Aloe spp. with antioxidant and antidiabetic properties

Aldayel, T. S., Grace, M. H., Lila, M. A., Yahya, M. A., Omar, U. M., & Alshammary, G. (2020, February 10). Arabian Journal of Chemistry, Vol. 13, pp. 5040–5049.

By: T. Aldayel*, M. Grace n, M. Lila n, M. Yahya*, U. Omar* & G. Alshammary*

Contributors: T. Aldayel*, M. Grace n, M. Lila n, M. Yahya*, U. Omar* & G. Alshammary*

author keywords: LC-ESI-IT-TOF; Aloe; Phenolics; alpha-Glucosidase inhibition; Antioxidant activity
topics (OpenAlex): Phytochemistry and biological activity of medicinal plants; Phytochemicals and Antioxidant Activities; Essential Oils and Antimicrobial Activity
TL;DR: Findings highlight the phytochemical profile, antioxidant and potential antidiabetic activity of the Yemeni Aloe species and draw attention to their potential application in food, medicine and cosmetic products. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 20, 2020

2020 article

Phenolic content, anti-inflammatory properties, and dermal wound repair properties of industrially processed and non-processed acai from the Brazilian Amazon

Xiong, J., Matta, F. V., Grace, M., Lila, M. A., Ward, N. I., Felipe-Sotelo, M., & Esposito, D. (2020, January 1). Food & Function, Vol. 11, pp. 4903–4914.

Contributors: J. Xiong n, F. Matta*, M. Grace n, M. Lila n, N. Ward*, M. Felipe-Sotelo*, D. Esposito n

MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Arecaceae; Brazil; Food Industry; Fruit; Humans; Mice; Phytotherapy; Plant Extracts / chemistry; Plant Extracts / pharmacology; Polyphenols / chemistry; RAW 264.7 Cells / drug effects; Wound Healing / drug effects
topics (OpenAlex): Bee Products Chemical Analysis; Botanical Research and Applications; Phytochemicals and Antioxidant Activities
TL;DR: The anti-inflammatory effect was diminished but wound healing effect was retained after pulp processing, suggesting the processing technology needs to be improved to maintain biological properties of acai fruit. (via Semantic Scholar)
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Source: ORCID
Added: June 5, 2020

2020 article

Skeletal Protection and Promotion of Microbiome Diversity by Dietary Boosting of the Endogenous Antioxidant Response

Sato, A. Y., Pellegrini, G. G., Cregor, M., McAndrews, K., Choi, R. B., Maiz, M., … Bellido, T. (2020, December 1). Journal of Bone and Mineral Research.

By: A. Sato*, G. Pellegrini*, M. Cregor*, K. McAndrews*, R. Choi*, M. Maiz*, O. Johnson*, L. McCabe* ...

author keywords: NUTRITION; GENETIC ANIMAL MODELS; SEX STEROIDS; OSTEOPOROSIS; THERAPEUTICS— OTHER
MeSH headings : Animals; Antioxidants; Bone and Bones; Diet; Female; Humans; Male; Mice; Microbiota; Phylogeny
topics (OpenAlex): Nutrition, Genetics, and Disease; Diet and metabolism studies; Vitamin D Research Studies
TL;DR: A blueberry cultivar that added to the diet protects female mice from musculoskeletal loss and body weight changes induced by ovariectomy and elicits antioxidant defense responses independently of classical antioxidant/estrogenic signaling, and increases gut microbiome diversity toward a healthier signature. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 19, 2021

2020 article

Skin Health from the Inside Out

Woodby, B., Penta, K., Pecorelli, A., Lila, M. A., & Valacchi, G. (2020, January 6). Annual Review of Food Science and Technology, Vol. 11, pp. 235–254.

By: B. Woodby n, K. Penta n, A. Pecorelli n, M. Lila n & G. Valacchi n

author keywords: pollution; skin; diet; GI tract; inflammation; antioxidant; vitamins
MeSH headings : Antioxidants / metabolism; Humans; Reactive Oxygen Species / metabolism; Skin Physiological Phenomena
topics (OpenAlex): Skin Protection and Aging; Vitamin C and Antioxidants Research; Antioxidant Activity and Oxidative Stress
TL;DR: This review discusses how topical application of antioxidants, including vitamins C and E, carotenoids, resveratrol, and pycnogenol, can be combined with dietary supplementation of these antioxidant compounds in addition to probiotics and essential minerals to protect against outdoor stressor-induced skin damage, including the damage associated with aging. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 27, 2020

2020 article

The Colors of Health: Chemistry, Bioactivity, and Market Demand for Colorful Foods and Natural Food Sources of Colorants

Mejia, E. G., Zhang, Q., Penta, K., Eroglu, A., & Lila, M. A. (2020, March 3). Annual Review of Food Science and Technology, Vol. 11, pp. 145–182.

By: E. Mejia*, Q. Zhang*, K. Penta n, A. Eroglu n & M. Lila n

author keywords: anthocyanins; betalains; bioactivity; carotenoids; natural colors; phycocyanins
MeSH headings : Color; Food; Pigments, Biological / chemistry
topics (OpenAlex): Botanical Research and Applications; Dye analysis and toxicity; Microbial Metabolism and Applications
TL;DR: The color industry needs new sources of stable, functional, and safe natural food colorants, and new opportunities include sourcing new colors from microbial sources and via the use of genetic biotechnology. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020

2020 article

The same anthocyanins served four different ways: Insights into anthocyanin structure-function relationships from the wintergreen orchid, Tipularia discolor

Hughes, N. M., Connors, M. K., Grace, M. H., Lila, M. A., Willans, B. N., & Wommack, A. J. (2020, December 10). Plant Science, Vol. 303.

By: N. Hughes*, M. Connors*, M. Grace n, M. Lila n, B. Willans* & A. Wommack*

author keywords: Abaxial/adaxial anthocyanins; Acylated cyanidin; 3,7,3 '-Triglucoside; Camouflage; Chemotaxonomy; Leaf color evolution; Herbivory defense
MeSH headings : Anthocyanins / chemistry; Anthocyanins / isolation & purification; Anthocyanins / physiology; Chromatography, High Pressure Liquid; Color; Gas Chromatography-Mass Spectrometry; Microscopy; Orchidaceae / metabolism; Orchidaceae / ultrastructure; Plant Leaves / metabolism; Plant Leaves / ultrastructure; Structure-Activity Relationship
topics (OpenAlex): Plant and animal studies; Plant Pathogens and Fungal Diseases; Horticultural and Viticultural Research
TL;DR: The results showed that the same three cyanidin 3,7,3'-triglucosides, in similar concentrations and proportions, accounted for coloration in each of these cases, and served as a reminder that plants may employ the same anthocyanins in different anatomical locations to achieve a broad range of colors. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 11, 2020

2020 article

Whey protein-polyphenol aggregate particles mitigate bar hardening reactions in high protein bars

Diaz, J. T., Foegeding, E. A., & Lila, M. A. (2020, December 11). LWT, Vol. 138.

By: J. Diaz n, E. Foegeding n & M. Lila n

author keywords: Protein bar; Texture; Polyphenol; Particle; Microstructure
topics (OpenAlex): Proteins in Food Systems; Microencapsulation and Drying Processes; Muscle metabolism and nutrition
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Sources: Web Of Science, NC State University Libraries
Added: February 15, 2021

2019 article

Alaskan Berry Extracts Promote Dermal Wound Repair Through Modulation of Bioenergetics and Integrin Signaling

Esposito, D., Overall, J., Grace, M. H., Komarnytsky, S., & Lila, M. A. (2019, September 27). Frontiers in Pharmacology, Vol. 10.

By: D. Esposito n, J. Overall n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: D. Esposito n, J. Overall n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: skin regeneration; wound healing; Alaskan berries; integrins; proanthocyanidins; epicatechins
topics (OpenAlex): Wound Healing and Treatments; Phytochemicals and Antioxidant Activities; Bee Products Chemical Analysis; Skin Protection and Aging
TL;DR: Targeting cellular bioenergetics and integrin-mediated cell–ECM signaling with bioactives from Alaskan wild berries shows considerable therapeutic promise to treat chronic skin wounds and inflammatory skin disorders, as well as more generally to support regenerative healing responses and restore function in a variety of tissue and organ settings after injury or aging. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 14, 2019

2019 article

Binding of peanut allergen Ara h 2 with Vaccinium fruit polyphenols

Plundrich, N. J., Cook, B. T., Maleki, S. J., Fourches, D., & Lila, M. A. (2019, January 18). Food Chemistry, Vol. 284, pp. 287–295.

By: N. Plundrich n, B. Cook n, S. Maleki*, D. Fourches n & M. Lila n

author keywords: Ara h 2; Molecular docking; Polyphenol; IgE binding; Circular dichroism (CD); Food allergy
MeSH headings : 2S Albumins, Plant / chemistry; 2S Albumins, Plant / immunology; 2S Albumins, Plant / metabolism; Antigens, Plant / chemistry; Antigens, Plant / immunology; Antigens, Plant / metabolism; Arachis / metabolism; Biflavonoids / chemistry; Biflavonoids / metabolism; Binding Sites; Catechin / chemistry; Catechin / metabolism; Chlorogenic Acid / chemistry; Chlorogenic Acid / metabolism; Circular Dichroism; Epitopes / chemistry; Epitopes / metabolism; Fruit / chemistry; Fruit / metabolism; Glycoproteins / chemistry; Glycoproteins / immunology; Glycoproteins / metabolism; Humans; Immunoglobulin E / chemistry; Immunoglobulin E / metabolism; Molecular Docking Simulation; Polyphenols / chemistry; Polyphenols / metabolism; Proanthocyanidins / chemistry; Proanthocyanidins / metabolism; Protein Binding; Protein Structure, Secondary; Spectrophotometry; Vaccinium / chemistry; Vaccinium / metabolism
topics (OpenAlex): Food Allergy and Anaphylaxis Research; Transgenic Plants and Applications; Allergic Rhinitis and Sensitization
TL;DR: Results suggest that certain polyphenols can inhibit IgE recognition of Ara h 2 by obstructing linear IgE epitopes. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 25, 2019

2019 article

Blueberries Topical Application Prevents Ozone Induced Cutaneous Inflammasome Activation

Pambianchi, E., Francesca, F., Pecorelli, A., Woodby, B., Lila, M., & Valacchi, G. (2019, November 15). Free Radical Biology and Medicine, Vol. 145, pp. S148–S148.

By: E. Pambianchi, F. Francesca, A. Pecorelli, B. Woodby, M. Lila & G. Valacchi

topics (OpenAlex): Medical and Biological Ozone Research; Skin Protection and Aging
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 article

Changes in the bioactive properties of strawberries caused by the storage in oxygen‐ and carbon dioxide‐enriched atmospheres

Velde, F. V., Esposito, D., Overall, J., Méndez‐Galarraga, M. P., Grace, M., Pirovani, M. É., & Lila, M. A. (2019, July 15). Food Science & Nutrition, Vol. 7, pp. 2527–2536.

By: F. Velde*, D. Esposito n, J. Overall n, M. Méndez‐Galarraga*, M. Grace n, M. Pirovani*, M. Lila n

Contributors: F. Velde*, D. Esposito n, J. Overall n, M. Méndez-Galarraga*, M. Grace n, M. Pirovani*, M. Lila n

author keywords: 2; 2-diphenyl-1-picrylhydrazil; cyclooxygenase-2; ferric reducing antioxidant power; human dermal fibroblast migration; interleukin-6; modified atmosphere storage
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Bee Products Chemical Analysis; Wound Healing and Treatments
TL;DR: Evidence suggests that strawberry storage in 90% O2 + 10% CO2 can be a promissory alternative to offer fruits with enhanced bioactivity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 5, 2019

2019 journal article

Comparison of berry juice concentrates and pomaces and alternative plant proteins to produce spray dried protein–polyphenol food ingredients

Food & Function, 10(10), 6286–6299.

By: R. Hoskin n, J. Xiong n & M. Lila n

Contributors: R. Hoskin n, J. Xiong n & M. Lila n

MeSH headings : Animals; Blueberry Plants / chemistry; Color; Fagopyrum / chemistry; Flour / analysis; Food Handling; Food Ingredients / analysis; Fruit / chemistry; Fruit and Vegetable Juices / analysis; Peas / chemistry; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Proteins / chemistry; Plant Proteins / isolation & purification; Polyphenols / chemistry; Polyphenols / isolation & purification; Vaccinium macrocarpon / chemistry; Vitis / chemistry; Waste Products / analysis
topics (OpenAlex): Seed and Plant Biochemistry; Food composition and properties; Proteins in Food Systems
TL;DR: The results suggest an efficient plant-based approach to produce value-added protein-polyphenol aggregates with broad utility as healthy food ingredients as well as good spray drying yield. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: November 4, 2019

2019 article

Immunometabolism: A Multi-Omics Approach to Interpreting the Influence of Exercise and Diet on the Immune System

Nieman, D. C., Lila, M. A., & Gillitt, N. D. (2019, January 11). Annual Review of Food Science and Technology, Vol. 10, pp. 341–363.

By: D. Nieman*, M. Lila n & N. Gillitt*

author keywords: exercise; diet; immune function; metabolomics; lipidomics; proteomics
MeSH headings : Diet; Exercise; Humans; Immune System; Metabolism
topics (OpenAlex): Exercise and Physiological Responses; Adipose Tissue and Metabolism; Metabolomics and Mass Spectrometry Studies
TL;DR: Emerging evidence using large multi-omics data sets supports the combined intake of fruit sugars and phytochemicals by athletes during heavy exertion as an effective strategy to improve metabolic recovery, augment viral defense, and counter postexercise inflammation and immune dysfunction at the cell level. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 22, 2019

2019 article

Peanut protein-polyphenol aggregate complexation suppresses allergic sensitization to peanut by reducing peanut-specific IgE in C3H/HeJ mice

Bansode, R. R., Randolph, P. D., Plundrich, N. J., Lila, M. A., & Williams, L. L. (2019, June 17). Food Chemistry, Vol. 299.

By: R. Bansode*, P. Randolph*, N. Plundrich n, M. Lila n & L. Williams*

author keywords: Peanut allergy; IgE; CD63; Polyphenol; Blueberry; Cranberry
MeSH headings : Animals; Arachis / chemistry; Arachis / immunology; Female; Immunoglobulin E / immunology; Mice; Mice, Inbred C3H; Peanut Hypersensitivity / prevention & control; Plant Proteins / chemistry; Plant Proteins / immunology; Polyphenols / chemistry; Species Specificity
topics (OpenAlex): Food Allergy and Anaphylaxis Research; Allergic Rhinitis and Sensitization; Contact Dermatitis and Allergies
TL;DR: It is demonstrated for the first time that complexation of polyphenols to peanut flour can potentially lower plasma IgE of peanut-sensitized C3H/HeJ mice. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019

2019 article

Photosynthetic Profiles of Green, Purple, and Spotted-Leaf Morphotypes of Tipularia discolor (Orchidaceae)

Hughes, N. M., Gigantino, G. M., Grace, M. H., Hoffman, K. M., Lila, M. A., Willans, B. N., & Wommack, A. J. (2019, December 13). Southeastern Naturalist, Vol. 18, pp. 641–658.

By: N. Hughes*, G. Gigantino*, M. Grace n, K. Hoffman*, M. Lila n, B. Willans*, A. Wommack*

Contributors: N. Hughes*, G. Gigantino*, M. Grace n, K. Hoffman*, M. Lila n, B. Willans*, A. Wommack*

topics (OpenAlex): Plant and animal studies; Horticultural and Viticultural Research; Plant Gene Expression Analysis
TL;DR: It is concluded that leaf purpling and spotting in Cranefly Orchid are most likely not related to physiological stress, and are more likely genetic in nature, perhaps representing alternative phenotypic adaptations related to herbivory defense. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 6, 2020

2019 article

Redox regulation of cutaneous inflammasome by ozone exposure

Ferrara, F., Pambianchi, E., Pecorelli, A., Woodby, B., Messano, N., Therrien, J.-P., … Valacchi, G. (2019, November 25). Free Radical Biology and Medicine, Vol. 152, pp. 561–570.

By: F. Ferrara*, E. Pambianchi*, A. Pecorelli*, B. Woodby*, N. Messano*, J. Therrien, M. Lila*, G. Valacchi*

MeSH headings : Caspase 1 / metabolism; Humans; Hydrogen Peroxide; Inflammasomes / metabolism; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Oxidation-Reduction; Ozone / toxicity; Reactive Oxygen Species
topics (OpenAlex): Inflammasome and immune disorders; Heme Oxygenase-1 and Carbon Monoxide; Medical and Biological Ozone Research
TL;DR: It is demonstrated that O3 can activate cutaneous inflammasome in a redox dependent manner suggesting a possible role of this new pathway in pollution induced inflammatory skin conditions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 13, 2020

2019 article

Variation in anthocyanin profiles of 27 genotypes of red cabbage over two growing seasons

Strauch, R. C., Mengist, M. F., Pan, K., Yousef, G. G., Iorizzo, M., Brown, A. F., & Lila, M. A. (2019, July 30). Food Chemistry, Vol. 301, p. 125289.

By: R. Strauch n, M. Mengist n, K. Pan n, G. Yousef n, M. Iorizzo n, A. Brown n, M. Lila n

Contributors: R. Strauch n, M. Mengist n, K. Pan n, G. Yousef n, M. Iorizzo n, A. Brown n, M. Lila n

author keywords: Red cabbage; Acylated anthocyanin; Breeding population; HPLC-DAD-MSE
MeSH headings : Acylation; Anthocyanins / analysis; Anthocyanins / chemistry; Brassica / chemistry; Brassica / genetics; Brassica / metabolism; Chromatography, High Pressure Liquid; Genotype; Mass Spectrometry; Plant Breeding; Polymorphism, Genetic; Seasons
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Fermentation and Sensory Analysis; Horticultural and Viticultural Research
TL;DR: PCA analysis identified anthocyanin accumulation traits and genotypes with high diversity which can be utilized in future investigations into the genetic and molecular basis for anthochenin production, acylation, and diversity. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 23, 2019

2018 article

Anti-inflammatory and wound healing properties of polyphenolic extracts from strawberry and blackberry fruits

Velde, F. V., Esposito, D., Grace, M. H., Pirovani, M. E., & Lila, M. A. (2018, November 28). Food Research International, Vol. 121, pp. 453–462.

By: F. Velde*, D. Esposito n, M. Grace n, M. Pirovani* & M. Lila n

Contributors: F. Velde*, D. Esposito n, M. Grace n, M. Pirovani* & M. Lila n

author keywords: Fragaria ananassa; Rubus fruticosus; Anthocyanins; Proanthocyanidins; Cyclooxygenase-2; Interleukin-6; Skin cell migration
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Anti-Inflammatory Agents / analysis; Anti-Inflammatory Agents / pharmacology; Antioxidants / analysis; Antioxidants / pharmacology; Cell Movement / drug effects; Cell Proliferation / drug effects; Cell Survival / drug effects; Chromatography, High Pressure Liquid; Fragaria / chemistry; Fruit / chemistry; Mice; Phytochemicals / analysis; Phytochemicals / pharmacology; Plant Extracts / analysis; Plant Extracts / pharmacology; Polyphenols / analysis; Polyphenols / pharmacology; Proanthocyanidins / analysis; Proanthocyanidins / pharmacology; RAW 264.7 Cells; Reactive Oxygen Species / metabolism; Rubus / chemistry; Wound Healing / drug effects
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Food Science and Nutritional Studies; Bee Products Chemical Analysis
TL;DR: Results obtained in this work highlight the anti-inflammatory properties of berry polyphenolics, especially due to proanthocyanidins, and promising results were obtained about the effects of bberry anthocyanins on wound healing. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2019

2018 journal article

Blueberry polyphenol-protein food ingredients: The impact of spray drying on the in vitro antioxidant activity, anti-inflammatory markers, glucose metabolism and fibroblast migration

Food Chemistry, 280, 187–194.

By: R. Hoskin n, J. Xiong n, D. Esposito n & M. Lila n

Contributors: R. Hoskin n, J. Xiong n, D. Esposito n & M. Lila n

author keywords: Berries; By-products; Drying; Inflammation; Phytochemicals
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Blueberry Plants / chemistry; Blueberry Plants / metabolism; Cell Line; Cell Movement / drug effects; Cell Survival / drug effects; Cyclooxygenase 2 / metabolism; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Freeze Drying; Glucose / metabolism; Interleukin-1beta / metabolism; Macrophages / cytology; Macrophages / drug effects; Macrophages / metabolism; Mice; Plant Proteins / chemistry; Plant Proteins / pharmacology; Polyphenols / chemistry; Polyphenols / pharmacology; Protein Aggregates; RAW 264.7 Cells; Rats; Reactive Oxygen Species / metabolism
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Microencapsulation and Drying Processes; Advanced Glycation End Products research
TL;DR: The data suggests that spray drying is a convenient and cost-effective technique to produce blueberry-polyphenol food ingredients with preserved phytochemicals with biological activities. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: January 28, 2019

2018 journal article

Changes due to high oxygen and high carbon dioxide atmospheres on the general quality and the polyphenolic profile of strawberries

Postharvest Biology and Technology, 148, 49–57.

By: F. Van de Velde*, M. Méndez-Galarraga*, M. Grace n, C. Fenoglio*, M. Lila n & M. Pirovani*

Contributors: F. Velde*, M. Méndez-Galarraga*, M. Grace n, C. Fenoglio*, M. Lila n & M. Pirovani*

author keywords: Modified atmosphere packaging; Abiotic stress; Anthocyanins; Phenolic acids; Ellagitannins; Vitamin C
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Postharvest Quality and Shelf Life Management; Plant responses to elevated CO2
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019

2018 journal article

In vitro mineral nutrition of Curcuma longa L. affects production of volatile compounds in rhizomes after transfer to the greenhouse

BMC Plant Biology, 18.

By: R. El-Hawaz, M. Grace, A. Janbey, M. Lila & J. Adelberg

Source: NC State University Libraries
Added: August 6, 2018

2018 article

In vitro mineral nutrition of Curcuma longa L. affects production of volatile compounds in rhizomes after transfer to the greenhouse (vol 18, 122, 2018)

BMC Plant Biology, Vol. 18.

By: R. El-Hawaz, M. Grace, A. Janbey, M. Lila & J. Adelberg

Source: NC State University Libraries
Added: August 6, 2018

2018 article

Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following 2-Weeks Flavonoid Supplementation

Nieman, D. C., Kay, C. D., Rathore, A. S., Grace, M. H., Strauch, R. C., Stephan, E. H., … Lila, M. A. (2018, October 15). Preprints.org, Vol. 10.

topics (OpenAlex): Exercise and Physiological Responses; Cardiovascular and exercise physiology; Muscle metabolism and nutrition
Source: ORCID
Added: November 13, 2019

2018 article

Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following Two Weeks of Flavonoid Supplementation

Nieman, D. C., Kay, C. D., Rathore, A. S., Grace, M. H., Strauch, R. C., Stephan, E. H., … Lila, M. A. (2018, November 9). Nutrients, Vol. 10.

By: D. Nieman*, C. Kay n, A. Rathore n, M. Grace n, R. Strauch n, E. Stephan*, C. Sakaguchi*, M. Lila n

Contributors: D. Nieman*, C. Kay n, A. Rathore n, M. Grace n, R. Strauch n, E. Stephan*, C. Sakaguchi*, M. Lila n

author keywords: exercise; polyphenol; metabolite; hippurate; intestinal tract; colon
MeSH headings : Adult; Dietary Supplements; Double-Blind Method; Exercise Test; Female; Flavonoids / blood; Flavonoids / pharmacokinetics; Flavonoids / pharmacology; Humans; Male; Oxygen Consumption; Phenols / blood; Physical Exertion; Plasma; Polyphenols / blood; Running / physiology; Walking / physiology
topics (OpenAlex): Medicinal Plants and Bioactive Compounds; Exercise and Physiological Responses; Phytochemicals and Antioxidant Activities; Cardiovascular and exercise physiology; Adipose Tissue and Metabolism
TL;DR: Data indicate that acute exercise bouts (brisk walking, intensive running) are linked to an increased translocation of gut-derived phenolics into circulation, an effect that is amplified when combined with a two-week period of increased flavonoid intake or chronic training as a runner. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

2018 article

LB1553 AtmO3spheric skin damage: The oxInflammation phenomena

Valacchi, G., Pecorelli, A., Pambianchi, E., Ferrara, F., & Lila, M. (2018, August 22). Journal of Investigative Dermatology, Vol. 138, pp. B15–15.

By: G. Valacchi n, A. Pecorelli*, E. Pambianchi*, F. Ferrara n & M. Lila*

topics (OpenAlex): Medical and Biological Ozone Research; Skin Protection and Aging
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2018

2018 article

Peanut flour aggregation with polyphenolic extracts derived from peanut skin inhibits IgE binding capacity and attenuates RBL-2H3 cells degranulation via MAPK signaling pathway

Bansode, R. R., Plundrich, N. J., Randolph, P. D., Lila, M. A., & Williams, L. L. (2018, May 3). Food Chemistry, Vol. 263, pp. 307–314.

By: R. Bansode*, N. Plundrich n, P. Randolph*, M. Lila n & L. Williams*

author keywords: Peanut skin; Peanut flour; Peanut allergy; Degranulation; Polyphenols; RBL-2H3 cells
MeSH headings : Allergens / immunology; Allergens / metabolism; Animals; Arachis / chemistry; Arachis / metabolism; Basophils / cytology; Basophils / drug effects; Basophils / metabolism; Cell Degranulation / drug effects; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Histamine / metabolism; Immunoglobulin E / analysis; Immunoglobulin E / immunology; MAP Kinase Signaling System / drug effects; Plant Proteins / immunology; Plant Proteins / metabolism; Polyphenols / chemistry; Polyphenols / pharmacology; Rats
topics (OpenAlex): Food Allergy and Anaphylaxis Research; Allergic Rhinitis and Sensitization; Eosinophilic Esophagitis
TL;DR: Results show that aggregation of PSP to PN proteins reduces allergic response by inhibiting Ca2+-induced MAPK-dependent cell degranulation. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 article

Reprint of ‘Protein-polyphenol particles for delivering structural and health functionality’

Foegeding, E. A., Plundrich, N., Schneider, M., Campbell, C., & Lila, M. A. (2018, March 15). Reprint of ‘Protein-polyphenol particles for delivering structural and health functionality.’ Food Hydrocolloids, Vol. 78, pp. 15–25.

By: E. Foegeding n, N. Plundrich n, M. Schneider n, C. Campbell n & M. Lila n

author keywords: Protein; Polyphenols; Colloidal aggregates; Health, and Structural Functionality
topics (OpenAlex): Proteins in Food Systems; Muscle metabolism and nutrition; Consumer Attitudes and Food Labeling
TL;DR: The overall goal should be a rational design of protein-polyphenol particles to ensure a positive contribution to food quality, protein nutrition, and delivery of a health-relevant dose of polyphenols to the gastrointestinal tract. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 article

SR-B1 involvement in keratinocytes in vitro wound closure

Muresan, X. M., Sticozzi, C., Belmonte, G., Cervellati, F., Ferrara, F., Lila, M. A., & Valacchi, G. (2018, September 18). Archives of Biochemistry and Biophysics, Vol. 658, pp. 1–6.

By: X. Muresan*, C. Sticozzi*, G. Belmonte*, F. Cervellati*, F. Ferrara*, M. Lila n, G. Valacchi n

author keywords: Wound healing; Skin; Proliferation; Migration
MeSH headings : Cell Line, Transformed; Cell Movement / physiology; Cell Proliferation / physiology; Cyclin D1 / metabolism; Gene Knockout Techniques; Humans; Keratinocytes / cytology; Keratinocytes / physiology; Matrix Metalloproteinase 9 / metabolism; NF-kappa B p50 Subunit / metabolism; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / physiology; Skin / metabolism; Wound Healing / physiology
topics (OpenAlex): Wound Healing and Treatments; Skin and Cellular Biology Research; Cellular Mechanics and Interactions
TL;DR: In vitro data demonstrated that SR-B1 influenced keratinocyte proliferation and migration through a downregulation of nuclear cyclin D1 levels and active MMP9 expression respectively possibly in an NF-kB-dependent mechanism, and suggests a new role of SRB1 as a possible new key player in cutaneous wound healing mechanism. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 26, 2018

2018 journal article

Simultaneous LC-MS quantification of anthocyanins and non-anthocyanin phenolics from blueberries with widely divergent profiles and biological activities

Food Chemistry, 277, 336–346.

By: M. Grace n, J. Xiong n, D. Esposito n, M. Ehlenfeldt* & M. Lila n

Contributors: M. Grace n, J. Xiong n, D. Esposito n, M. Ehlenfeldt* & M. Lila n

author keywords: Pink-fruited; Blueberries; LC-IT-TOF-MS; Quantification; Antioxidant; Anti-inflammatory; PCA
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Anti-Inflammatory Agents / analysis; Anti-Inflammatory Agents / pharmacology; Antioxidants / analysis; Antioxidants / pharmacology; Biological Assay; Blueberry Plants / chemistry; Cell Survival / drug effects; Chromatography, Liquid; Color; Flavonoids / analysis; Flavonoids / pharmacology; Flavonols / analysis; Flavonols / pharmacology; Fruit / chemistry; Hydroxybenzoates / analysis; Hydroxybenzoates / pharmacology; Limit of Detection; Mass Spectrometry; Mice; Nitric Oxide / metabolism; Phenols / analysis; Phenols / pharmacology; Plant Extracts / analysis; Plant Extracts / pharmacology; RAW 264.7 Cells; Reactive Oxygen Species / metabolism; Reproducibility of Results; Resveratrol / analysis; Resveratrol / pharmacology
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Antioxidant Activity and Oxidative Stress; Plant Gene Expression Analysis
TL;DR: A sensitive and straightforward LC-IT-TOF-MS method was validated for the profiling and simultaneous quantification of anthocyanins, flavan-3-ols, flavonols, phenolic acids, and resveratrol in blueberry genotypes with fruit color ranging from deep purple to various shades of pink. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 17, 2018

2018 article

Tropospheric ozone affects SRB1 levels via oxidative post-translational modifications in lung cells

Sticozzi, C., Pecorelli, A., Romani, A., Belmonte, G., Cervellati, F., Maioli, E., … Valacchi, G. (2018, July 27). Free Radical Biology and Medicine, Vol. 126, pp. 287–295.

By: C. Sticozzi*, A. Pecorelli*, A. Romani*, G. Belmonte*, F. Cervellati*, E. Maioli*, M. Lila*, C. Cervellati*, G. Valacchi*

MeSH headings : A549 Cells; Aldehydes / metabolism; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Antioxidants / pharmacology; Biological Transport / drug effects; Catalase / genetics; Catalase / metabolism; Cell Survival / drug effects; Humans; Hydrogen Peroxide / metabolism; Lung / drug effects; Lung / metabolism; Lung / pathology; Oxidation-Reduction / drug effects; Oxidative Stress / drug effects; Ozone / pharmacology; Protein Processing, Post-Translational / drug effects; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / metabolism; Vitamin E / metabolism
topics (OpenAlex): Air Quality and Health Impacts; Antioxidant Activity and Oxidative Stress; Heme Oxygenase-1 and Carbon Monoxide
TL;DR: To characterize the molecular mechanism involved in the redox modulation of SRB1, its cellular levels were assessed in human alveolar epithelial cells after O3 exposure and it was demonstrated that O3 induced the loss ofSRB1 protein levels, a mechanism that could account for SRB 1 protein loss. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 16, 2018

2017 journal article

Anthocyanins in metabolic health and disease

Nutrigenomics and Proteomics in Health and Disease: towards a Systems-Level Understanding of Gene-Diet Interactions, 2nd Edition, 92–124.

By: J. Overall, M. Lila & S. Komarnytsky

Source: NC State University Libraries
Added: August 6, 2018

2017 article

Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage

Skates, E., Overall, J., DeZego, K., Wilson, M., Esposito, D., Lila, M. A., & Komarnytsky, S. (2017, November 28). Food and Chemical Toxicology, Vol. 111, pp. 445–453.

By: E. Skates n, J. Overall n, K. DeZego n, M. Wilson n, D. Esposito n, M. Lila n, S. Komarnytsky n

author keywords: Bioactive food components; Polyphenols; Obesity; Diabetes; Bioenergetics; Functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Diet; Diet, High-Fat / adverse effects; Energy Metabolism; Fruit / chemistry; Lipid Metabolism; Male; Metabolic Diseases; Methylation; Mice; Mice, Inbred C57BL; Rubus / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Adipose Tissue and Metabolism; Sirtuins and Resveratrol in Medicine
TL;DR: It is shown that consumption of berries containing anthocyanins with enhanced methylation profiles (malvidin and petunidin) is more effective at reducing high fat diet-induced metabolic damage in the C57BL/6 mouse model of polygenic obesity. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 article

Development, and genetic and metabolic characterization of new tomato mutants with enhanced and deficient carotenoid content

Dan, Y., Yousef, G., Campbell, F. N., Phelps, D. W., Burnett, C., Kekkonen, A., … Lila, M. A. (2017, March 30). The Journal of Horticultural Science and Biotechnology, Vol. 3, pp. 1–9.

By: Y. Dan*, G. Yousef n, F. Campbell*, D. Phelps*, C. Burnett*, A. Kekkonen*, A. Shockley*, M. Lila n

author keywords: Carotenoid; lycopene; -carotene; Solanum lycopersicum; mutagenesis
topics (OpenAlex): Antioxidant Activity and Oxidative Stress; Photosynthetic Processes and Mechanisms; Plant biochemistry and biosynthesis
TL;DR: Genetic and metabolic analyses showed that new mutants with enhanced and deficient carotenoid content in a single genetic background of tomato cv. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Effect of 4 weeks of high-intensity interval training on exercise performance and markers of inflammation and oxidative stress

FASEB Journal, 31.

By: K. Zwetsloot, D. Nieman, A. Knab, C. John, D. Lomiwes, R. Hurst, N. Gillitt, M. Lila

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Health modifying regions in the oat (Avena sativa) genome responsible for beneficial effects on immune and gastrointestinal health

FASEB Journal, 31.

By: W. Bussler, K. Dezego, M. Bowen, A. Buige, D. Esposito, M. Lila, S. Komarnytsky

Source: NC State University Libraries
Added: August 6, 2018

2017 article

In vitro Hypoallergenicity of Peanut Protein-Blueberry Polyphenol Aggregate Particles

Plundrich, N., Bansode, R., Williams, L., & Lila, M. A. (2017, February 1). Journal of Allergy and Clinical Immunology, Vol. 139, pp. AB139–139.

By: N. Plundrich n, R. Bansode*, L. Williams* & M. Lila n

topics (OpenAlex): Food Allergy and Anaphylaxis Research
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

In vitro hypoallergenic potential of peanut protein-polyphenol aggregate particles

FASEB Journal, 31.

By: N. Plundrich, R. Bansode, L. Williams & M. Lila

Source: NC State University Libraries
Added: August 6, 2018

2017 article

Influence of Ingesting a Flavonoid-Rich Supplement on the Metabolome and Concentration of Urine Phenolics in Overweight/Obese Women

Nieman, D. C., Ramamoorthy, S., Kay, C. D., Goodman, C. L., Capps, C. R., Shue, Z. L., … Lila, M. A. (2017, June 20). Journal of Proteome Research, Vol. 16, pp. 2924–2935.

By: D. Nieman*, S. Ramamoorthy*, C. Kay n, C. Goodman*, C. Capps*, Z. Shue*, N. Heyl*, M. Grace n, M. Lila n

Contributors: D. Nieman*, S. Ramamoorthy*, C. Kay n, C. Goodman*, C. Capps*, Z. Shue*, N. Heyl*, M. Grace n, M. Lila n

author keywords: dietary supplement; metabolomics; polyphenol; obesity
MeSH headings : Adolescent; Adult; Aged; Dietary Supplements; Female; Flavonoids / administration & dosage; Flavonoids / pharmacology; Humans; Intestinal Mucosa / metabolism; Metabolome / drug effects; Metabolomics / methods; Middle Aged; Obesity / metabolism; Obesity / urine; Overweight / metabolism; Overweight / urine; Phenols / urine; Young Adult
topics (OpenAlex): Tea Polyphenols and Effects; Phytochemicals and Antioxidant Activities; Natural Antidiabetic Agents Studies
TL;DR: It was shown that 12 weeks ingestion of a mixed flavonoid nutrient supplement was associated with a corresponding increase in urine total phenolics and gut-derived phenolic metabolites. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 article

Inter- and intra-seasonal changes in anthocyanin accumulation and global metabolite profiling of six blueberry genotypes

Timmers, M. A., Grace, M. H., Yousef, G. G., & Lila, M. A. (2017, February 28). Journal of Food Composition and Analysis, Vol. 59, pp. 105–110.

By: M. Timmers n, M. Grace n, G. Yousef n & M. Lila n

Contributors: M. Timmers n, M. Grace n, G. Yousef n & M. Lila n

author keywords: Anthocyanin; HPLC; PCA; Blueberry; Metabolite profile; Genotype and seasonal variations; Food analysis; Food composition
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Plant Gene Expression Analysis; Horticultural and Viticultural Research
TL;DR: Genotypes were easily distinguished from one another across each harvest season, indicating that each genotype had distinctly different metabolite profile, whereas each of the rabbiteye genotypes overlapped on the scores plot, indicating commonalities in metabolite profiles. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 article

Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms

Rus Jacquet, A., Timmers, M., Ma, S. Y., Thieme, A., McCabe, G. P., Vest, J. H. C., … Rochet, J.-C. (2017, February 15). Journal of Ethnopharmacology, Vol. 206, pp. 408–425.

By: A. Rus Jacquet*, M. Timmers n, S. Ma*, A. Thieme*, G. McCabe*, J. Vest*, M. Lila n, J. Rochet*

MeSH headings : Humans; Indians, North American; Medicine, Traditional; Parkinson Disease / drug therapy; Parkinson Disease / physiopathology; Plants, Medicinal / chemistry
topics (OpenAlex): Biochemical and biochemical processes; Parkinson's Disease Mechanisms and Treatments; Medicinal Plants and Neuroprotection
TL;DR: Analysis of contemporary herbal medicinal practices used by members of the Lumbee tribe to treat PD-related symptoms highlights potential therapeutic benefits of botanical extracts used in traditional Lumbee medicine, and provides insight into mechanisms by which an elderflower extract could suppress neurotoxicity elicited by environmental and genetic PD- related insults. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 article

Metabolic Effects of Berries with Structurally Diverse Anthocyanins

Overall, J., Bonney, S., Wilson, M., Beermann, A., Grace, M., Esposito, D., … Komarnytsky, S. (2017, February 15). International Journal of Molecular Sciences, Vol. 18.

By: J. Overall n, S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n, D. Esposito n, M. Lila n, S. Komarnytsky n

Contributors: J. Overall n, S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n, D. Esposito n, M. Lila n, S. Komarnytsky n

author keywords: berry; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Anthocyanins / metabolism; Body Composition; Body Weight; Chromatography, High Pressure Liquid; Dietary Supplements; Feces / chemistry; Fruit / metabolism; Gastrointestinal Microbiome; Glucose / metabolism; Humans; Insulin Resistance; Mice; Molecular Structure; Oxygen Consumption
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Diet and metabolism studies; Metabolomics and Mass Spectrometry Studies
TL;DR: Examination of effects of six berries with structurally diverse anthocyanin profiles on development of metabolic risk factors in the C57BL/6 mouse model of polygenic obesity showed a prominent discrepancy between biological activities of delphinidin/malvidin-versus cyanidin-type anthocianins that could be explained by differences in their structure and metabolism in the gut. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Polyphenol-enriched berry extracts naturally modulate reactive proteins in model foods

Food & Function, 8(12), 4760–4767.

By: M. Lila n, M. Schneider n, A. Devlin n, N. Plundrich n, S. Laster n & E. Foegeding n

MeSH headings : Animals; Dendritic Cells / immunology; Food Hypersensitivity / prevention & control; Fruit / chemistry; Fruit and Vegetable Juices / analysis; Functional Food / analysis; Humans; Macrophages / immunology; Ovalbumin / chemistry; Ovalbumin / immunology; Plant Extracts / chemistry; Polyphenols / chemistry; Swine; Tumor Necrosis Factor-alpha / immunology; Whey Proteins / chemistry; Whey Proteins / immunology
topics (OpenAlex): Food Allergy and Anaphylaxis Research; Proteins in Food Systems; Muscle metabolism and nutrition
TL;DR: The reactive allergenic epitopes of certain proteins were effectively blunted by binding with polyphenols, attenuating the allergenicity of the food proteins, allowing for the potential creation of hypoallergenic protein-berry polyphenol enriched foods. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 17, 2020

2017 journal article

Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities

Chinese Journal of Natural Medicines, 15(11), 816–824.

By: J. Xiong n, M. Grace n, D. Esposito n, S. Komarnytsky n, F. Wang* & M. Lila n

Contributors: J. Xiong n, M. Grace n, D. Esposito n, S. Komarnytsky n, F. Wang* & M. Lila n

author keywords: Acacia mearnsii; Proanthocyanidins; Anti-inflammatory; alpha-Amylase; alpha-Glucosidase
MeSH headings : Acacia / chemistry; Animals; Anti-Inflammatory Agents / isolation & purification; Anti-Inflammatory Agents / pharmacology; Carbohydrate Metabolism / drug effects; Glycoside Hydrolase Inhibitors / pharmacology; Inflammation / metabolism; Interleukin-1beta / metabolism; Lipopolysaccharides; Macrophages / drug effects; Mice; Nitric Oxide / metabolism; Nitric Oxide Synthase Type II / metabolism; Plant Bark / chemistry; Plant Extracts / chemistry; Plant Extracts / pharmacology; Polyphenols / isolation & purification; Polyphenols / pharmacology; Proanthocyanidins / pharmacology; RAW 264.7 Cells; alpha-Amylases / antagonists & inhibitors; alpha-Glucosidases / metabolism
topics (OpenAlex): Chromatography in Natural Products; Phytochemicals and Antioxidant Activities; Bioactive natural compounds
TL;DR: Polyphenols isolated from Acacia mearnsii bark crude extract and fractions obtained by high-speed counter-current chromatography and evaluated their anti-inflammatory and carbolytic enzymes (α-glucosidase and α-amylase) inhibitory activities showed significant activities against reactive oxygen species, nitric oxide production, and expression of pro-inflammatory genes interleukin-1β. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2017 article

Protein-bound Vaccinium fruit polyphenols decrease IgE binding to peanut allergens and RBL-2H3 mast cell degranulation in vitro

Plundrich, N. J., Bansode, R. R., Foegeding, E. A., Williams, L. L., & Lila, M. A. (2017, January 1). Food & Function, Vol. 8, pp. 1611–1621.

By: N. Plundrich n, R. Bansode*, E. Foegeding n, L. Williams* & M. Lila n

MeSH headings : Allergens / immunology; Arachis / immunology; Cell Degranulation / drug effects; Fruit / chemistry; Humans; Immunoglobulin E / immunology; Mast Cells / drug effects; Mast Cells / immunology; Mast Cells / physiology; Peanut Hypersensitivity / drug therapy; Peanut Hypersensitivity / immunology; Plant Extracts / pharmacology; Plant Proteins / immunology; Polyphenols / pharmacology; Vaccinium / chemistry
topics (OpenAlex): Food Allergy and Anaphylaxis Research; Transgenic Plants and Applications; Respiratory and Cough-Related Research; Allergic Rhinitis and Sensitization; Pediatric health and respiratory diseases
TL;DR: The modification of peanut proteins with cranberry or blueberry polyphenols led to the formation of peanut protein-polyphenol complexes with significantly reduced allergenic potential. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 article

Protein-bound polyphenols create “ghost” band artifacts during chemiluminescence-based antigen detection

Plundrich, N., Lila, M. A., Foegeding, E., & Laster, S. (2017, March 13). F1000Research, Vol. 6, p. 254.

topics (OpenAlex): Advanced Biosensing Techniques and Applications; bioluminescence and chemiluminescence research; Biosensors and Analytical Detection
Source: ORCID
Added: February 17, 2020

2017 article

Protein-bound polyphenols create “ghost” band artifacts during chemiluminescence-based antigen detection

Plundrich, N., Lila, M. A., Foegeding, E., & Laster, S. (2017, May 26). F1000Research, Vol. 6, p. 254.

topics (OpenAlex): Advanced Biosensing Techniques and Applications; Monoclonal and Polyclonal Antibodies Research; Food Allergy and Anaphylaxis Research
TL;DR: This study suggests that caution should be taken when evaluating polyphenol-bound proteins by enhanced chemiluminescence Western blotting using horseradish peroxidase and demonstrates that protein-bound polyphenols can be a source of “ghost” band artifacts on Western blots. (via Semantic Scholar)
Source: ORCID
Added: February 17, 2020

2017 article

Protein-polyphenol particles for delivering structural and health functionality

Foegeding, E. A., Plundrich, N., Schneider, M., Campbell, C., & Lila, M. A. (2017, June 6). Food Hydrocolloids, Vol. 72, pp. 163–173.

By: E. Foegeding n, N. Plundrich n, M. Schneider n, C. Campbell n & M. Lila n

author keywords: Protein; Polyphenols; Colloidal aggregates; Health, and Structural Functionality
topics (OpenAlex): Proteins in Food Systems; Muscle metabolism and nutrition; Consumer Attitudes and Food Labeling
TL;DR: The overall goal should be a rational design of protein-polyphenol particles to ensure a positive contribution to food quality, protein nutrition, and delivery of a health-relevant dose of polyphenols to the gastrointestinal tract. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 article

Wild blueberry polyphenol-protein food ingredients produced by three drying methods: Comparative physico-chemical properties, phytochemical content, and stability during storage

Correia, R., Grace, M. H., Esposito, D., & Lila, M. A. (2017, May 11). Food Chemistry, Vol. 235, pp. 76–85.

By: R. Correia n, M. Grace n, D. Esposito n & M. Lila n

Contributors: R. Correia n, M. Grace n, D. Esposito n & M. Lila n

author keywords: Soy protein isolate; By-products; Spray drying; Phenolics; Shelf life
MeSH headings : Anthocyanins / analysis; Antioxidants; Blueberry Plants / chemistry; Desiccation / methods; Food Handling / methods; Freeze Drying; Phytochemicals; Polyphenols
topics (OpenAlex): Microencapsulation and Drying Processes; Phytochemicals and Antioxidant Activities; Botanical Research and Applications
TL;DR: Overall, spray drying the blueberry extracts complexed with protein proved to be an environment-friendly strategy to produce stable functional ingredients with multiple applications for the food industry. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

alpha-Amylase and alpha-Glucosidase inhibitory activities of phenolic extracts from Eucalyptus grandis x E-urophylla Bark

Journal of Chemistry.

By: P. Jiang, J. Xiong, F. Wang, M. Grace, M. Lila & R. Xu

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

α-Amylase and α-Glucosidase Inhibitory Activities of Phenolic Extracts from Eucalyptus grandis × E. urophylla Bark

Journal of Chemistry, 2017, 1–7.

By: P. Jiang*, J. Xiong*, F. Wang*, M. Grace n, M. Lila n & R. Xu*

Contributors: P. Jiang*, J. Xiong*, F. Wang*, M. Grace n, M. Lila n & R. Xu*

topics (OpenAlex): Natural Antidiabetic Agents Studies; Enzyme Production and Characterization; Sugarcane Cultivation and Processing
Sources: ORCID, Crossref, NC State University Libraries
Added: November 12, 2019

2016 journal article

A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice

The Journal of Nutritional Biochemistry, 31, 150–165.

By: B. Collins*, J. Hoffman*, K. Martinez*, M. Grace*, M. Lila*, C. Cockrell*, A. Nadimpalli*, E. Chang* ...

Contributors: B. Collins*, J. Hoffman*, K. Martinez*, M. Grace*, M. Lila*, C. Cockrell*, A. Nadimpalli*, E. Chang* ...

author keywords: Grapes; Obesity; Steatosis; Inflammation; Intestines; Microbiota
MeSH headings : Adiposity / drug effects; Animals; Biomarkers / metabolism; Diet, High-Fat; Gastrointestinal Microbiome / drug effects; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Polyphenols / pharmacology; Vitis / chemistry
topics (OpenAlex): Dietary Effects on Health; Adipokines, Inflammation, and Metabolic Diseases; Ginger and Zingiberaceae research
TL;DR: Data demonstrate that the polyphenol-rich, EP fraction from table grapes attenuated many of the adverse health consequences associated with consuming an HF diet. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019

2016 journal article

Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts

Food Chemistry, 210, 85–95.

By: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

Contributors: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

author keywords: Anacardic acids; Triterpene acids; Carotenoids; Tocopherols; Polyphenols; Anti-inflammatory
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / isolation & purification; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / isolation & purification; Antioxidants / pharmacology; Cell Line; Dose-Response Relationship, Drug; Macrophages / drug effects; Macrophages / metabolism; Mice; Pistacia; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Extracts / pharmacology; Reactive Oxygen Species / antagonists & inhibitors; Reactive Oxygen Species / metabolism
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Antioxidant Activity and Oxidative Stress; Pomegranate: compositions and health benefits
TL;DR: The P extract significantly decreased the non-mitochondrial oxidative burst associated with inflammatory response in macrophages and significantly inhibited the release of nitric oxide and reactive oxygen species in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Formation of whey protein–polyphenol meso-structures as a natural means of creating functional particles

Food & Function, 7(3), 1306–1318.

By: M. Schneider n, D. Esposito n, M. Lila n & E. Foegeding n

MeSH headings : Fruit / chemistry; Hydrogen-Ion Concentration; Particle Size; Plant Extracts / chemistry; Polyphenols / chemistry; Ribes / chemistry; Vaccinium macrocarpon / chemistry; Vitis / chemistry; Whey Proteins / chemistry
topics (OpenAlex): Proteins in Food Systems; Microencapsulation and Drying Processes; Protein Hydrolysis and Bioactive Peptides
TL;DR: Particles improved foam stability, and the anti-inflammatory properties of entrapped polyphenols were maintained in the particles, suggesting highly functional protein-polyphenol particles can be designed to stabilize food structures and simultaneously deliver polyphenol associated with health benefits. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2016 article

Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015

Blumberg, J. B., Basu, A., Krueger, C. G., Lila, M. A., Neto, C. C., Novotny, J. A., … Toner, C. D. (2016, July 1). Advances in Nutrition, Vol. 7, pp. 759S–770.

author keywords: cranberry; proanthocyanidins; microbiome; cardiometabolic; antimicrobial
MeSH headings : Animals; Anti-Infective Agents; Biofilms; Diet; Fruit / chemistry; Gastrointestinal Microbiome / physiology; Health Promotion; Heart Diseases / prevention & control; Humans; Inflammation; Lipids / blood; Metabolic Diseases / prevention & control; Oxidative Stress; Phytochemicals / administration & dosage; Phytochemicals / analysis; Plant Extracts / pharmacology; Proanthocyanidins; Risk Factors; Vaccinium macrocarpon / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Gut microbiota and health; Microbial Metabolites in Food Biotechnology
TL;DR: A limited but growing body of evidence from randomized clinical trials reveals favorable effects of cranberry consumption on measures of cardiometabolic health, including serum lipid profiles, blood pressure, endothelial function, glucoregulation, and a variety of biomarkers of inflammation and oxidative stress. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 article

Impact of a new postharvest disinfection method based on peracetic acid fogging on the phenolic profile of strawberries

Velde, F. V., Grace, M. H., Pirovani, M. É., & Lila, M. A. (2016, March 15). Postharvest Biology and Technology, Vol. 117, pp. 197–205.

By: F. Velde*, M. Grace n, M. Pirovani* & M. Lila n

Contributors: F. Velde*, M. Grace n, M. Pirovani* & M. Lila n

author keywords: Nebulization; Anthocyanins; Proanthocyanidins; Hydroxycinnamic acid derivatives; Ellagitannins
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Postharvest Quality and Shelf Life Management; Horticultural and Viticultural Research
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

In vitro lipolytic, antioxidant and anti-inflammatory activities of roasted pistachio kernel and skin constituents

Food & Function, 7(10), 4285–4298.

By: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

Contributors: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

MeSH headings : Animals; Antioxidants; Cell Survival / drug effects; Cooking; Macrophages / drug effects; Macrophages / metabolism; Mice; Phytochemicals; Pistacia / chemistry; RAW 264.7 Cells; Reactive Oxygen Species; Respiratory Burst; Seeds / chemistry
topics (OpenAlex): Nuts composition and effects; African Botany and Ecology Studies; Banana Cultivation and Research
TL;DR: The SNP had the strongest effect in decreasing non-mitochondrial oxidative burst associated with inflammatory response in macrophages, and was the most potent to inhibit the expression of COX2. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2016 article

One‐step isolation of carnosic acid and carnosol from rosemary by centrifugal partition chromatography

Grace, M. H., Qiang, Y., Sang, S., & Lila, M. A. (2016, December 24). Journal of Separation Science, Vol. 40, pp. 1057–1062.

By: M. Grace n, Y. Qiang n, S. Sang* & M. Lila n

Contributors: M. Grace n, Y. Qiang n, S. Sang* & M. Lila n

author keywords: carnosic acid; carnosol; centrifugal partition chromatography; Rosmarinus officinalis
MeSH headings : Abietanes / isolation & purification; Chromatography; Plant Extracts / chemistry; Rosmarinus / chemistry
topics (OpenAlex): Chromatography in Natural Products; Natural product bioactivities and synthesis; Phytochemicals and Antioxidant Activities
TL;DR: Carnosic acid and carnosol are the main bioactive components responsible for the significant antioxidant activity of Rosmarinus officinalis and were identified by mass spectrometry, tandem mass spectromaetry, and comparison with authentic standards. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Phytochemical characterization and anti-inflammatory properties of Acacia mearnsii leaves

Natural Product Communications, 11(5), 649–653.

By: J. Xiong, M. Grace, D. Esposito, F. Wang & M. Lila

Source: NC State University Libraries
Added: August 6, 2018

2016 article

Quantitative comparison of phytochemical profile, antioxidant, and anti-inflammatory properties of blackberry fruits adapted to Argentina

Velde, F. V., Grace, M. H., Esposito, D., Pirovani, M. É., & Lila, M. A. (2016, January 24). Journal of Food Composition and Analysis, Vol. 47, pp. 82–91.

By: F. Velde*, M. Grace n, D. Esposito n, M. Pirovani* & M. Lila n

Contributors: F. Velde*, M. Grace n, D. Esposito n, M. Pirovani* & M. Lila n

author keywords: Bubo fruticosus; Polyphenols content; Vitamin C; Cyanidin-3-O-glucoside; Proanthocyanidins; Reactive oxygen species; Cyclooxygenase-2; Interleukin-6; Food analysis; Food composition
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Psidium guajava Extracts and Applications; Morinda citrifolia extract uses
TL;DR: The potential of blackberries cultivars ‘Black Satin’ and ‘Jumbo’ to contribute to a healthy diet, based on their higher polyphenol content, providing higher antioxidant and anti-inflammatory properties is suggested. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 review

Unraveling anthocyanin bioavailability for human health

[Review of ]. Annual review of food science and technology, vol 7, 7, 375–393.

By: M. Lila, B. Burton-Freeman, M. Grace & W. Kalt

Source: NC State University Libraries
Added: August 6, 2018

2015 article

Alaskan seaweeds lower inflammation in RAW 264.7 macrophages and decrease lipid accumulation in 3T3-L1 adipocytes

Kellogg, J., Esposito, D., Grace, M. H., Komarnytsky, S., & Lila, M. A. (2015, April 14). Journal of Functional Foods, Vol. 15, pp. 396–407.

By: J. Kellogg n, D. Esposito n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: J. Kellogg n, D. Esposito n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: Seaweed; Phlorotannin; Monoglycosyldiacylglycerol; Inflammation; Insulin resistance; Fucus distichus
topics (OpenAlex): Seaweed-derived Bioactive Compounds; Fatty Acid Research and Health; Adipokines, Inflammation, and Metabolic Diseases
TL;DR: Overall, the Alaskan seaweed F. distichus inhibited proinflammatory responses and improved lipid metabolism, suggesting the potential for seaweed phytochemicals to attenuate inflammatory diseases. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 article

Black Currant Anthocyanins Attenuate Weight Gain and Improve Glucose Metabolism in Diet-Induced Obese Mice with Intact, but Not Disrupted, Gut Microbiome

Esposito, D., Damsud, T., Wilson, M., Grace, M. H., Strauch, R., Li, X., … Komarnytsky, S. (2015, June 12). Journal of Agricultural and Food Chemistry, Vol. 63, pp. 6172–6180.

By: D. Esposito n, T. Damsud n, M. Wilson n, M. Grace n, R. Strauch n, X. Li n, M. Lila n, S. Komarnytsky n

Contributors: D. Esposito n, T. Damsud n, M. Wilson n, M. Grace n, R. Strauch n, X. Li n, M. Lila n, S. Komarnytsky n

author keywords: gastrointestinal tract; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animals; Anthocyanins / administration & dosage; Anthocyanins / chemistry; Fruit / chemistry; Gastrointestinal Microbiome / drug effects; Glucose / metabolism; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity / drug therapy; Obesity / metabolism; Obesity / microbiology; Obesity / physiopathology; Plant Extracts / administration & dosage; Plant Extracts / chemistry; Ribes / chemistry; Weight Gain / drug effects
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Biochemical Analysis and Sensing Techniques; Gut microbiota and health
TL;DR: The data clearly demonstrate that gut microbiome and the type of the anthocyanin aglycone moiety can alter the protective effect of Anthocyanins against obesity and associated insulin resistance. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 article

Characterization of Phenolic Compounds and Antioxidant and Anti-inflammatory Activities from Mamuyo (Styrax ramirezii Greenm.) Fruit

Timmers, M. A., Guerrero-Medina, J. L., Esposito, D., Grace, M. H., Paredes-López, O., García-Saucedo, P. A., & Lila, M. A. (2015, November 17). Journal of Agricultural and Food Chemistry, Vol. 63, pp. 10459–10465.

author keywords: LC-TOF-MS; Styrax ramirezii; antioxidant activity; anti-inflammatory activity; norneolignan
MeSH headings : Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / pharmacology; Cyclooxygenase 2 / immunology; Fruit / chemistry; Humans; Interleukin-1beta / immunology; Nitric Oxide / immunology; Nitric Oxide Synthase Type II / immunology; Nitric Oxide Synthase Type II / metabolism; Phenols / chemistry; Phenols / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology; Reactive Oxygen Species / metabolism; Styrax / chemistry
topics (OpenAlex): Plant-derived Lignans Synthesis and Bioactivity; Phytochemistry and Biological Activities; Traditional and Medicinal Uses of Annonaceae
TL;DR: Egonol potently inhibited the production of NO and also significantly reduced the release of ROS, suggesting the potential of S. ramirezii Greenm. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 article

Community-Based Research as a Mechanism to Reduce Environmental Health Disparities in American Indian and Alaska Native Communities

McOliver, C., Camper, A., Doyle, J., Eggers, M., Ford, T., Lila, M., … Donatuto, J. (2015, April 13). International Journal of Environmental Research and Public Health, Vol. 12, pp. 4076–4100.

By: C. McOliver*, A. Camper*, J. Doyle*, M. Eggers*, T. Ford*, M. Lila n, J. Berner*, L. Campbell, J. Donatuto

MeSH headings : Alaska; Climate Change; Community-Based Participatory Research; Environmental Health; Female; Health Status Disparities; Humans; Indians, North American; Male; Minority Groups; Quality of Life; United States; United States Environmental Protection Agency
topics (OpenAlex): Indigenous Studies and Ecology; Indigenous Health, Education, and Rights; Climate Change and Health Impacts
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science)
15. Life on Land (Web of Science)
Sources: ORCID, NC State University Libraries
Added: June 8, 2024

2015 journal article

Community-based research as a mechanism to reduce environmental health disparities in American Indian and Alaska native communities

International Journal of Environmental Research and Public Health, 12(4), 4076–4100.

By: C. McOliver, A. Camper, J. Doyle, M. Eggers, T. Ford, M. Lila, J. Berner, L. Campbell, J. Donatuto

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Method to harness bioactive secondary metabolites from intact Quinoa seeds with implications for chronic disease prevention

Planta Medica, 81(11).

By: B. Graf*, A. Poulev*, P. Kuhn*, D. Esposito n, M. Lila n & I. Raskin*

topics (OpenAlex): Seed and Plant Biochemistry
Sources: Crossref, NC State University Libraries
Added: February 21, 2020

2015 journal article

New functionally-enhanced soy proteins as food ingredients with anti-viral activity

VirusDisease, 26(3), 123–132.

By: A. Turmagambetova*, N. Sokolova*, A. Bogoyavlenskiy*, V. Berezin*, M. Lila n, D. Cheng*, V. Dushenkov*

topics (OpenAlex): Transgenic Plants and Applications; Plant Virus Research Studies; Probiotics and Fermented Foods; GABA and Rice Research
TL;DR: Anti-viral properties of both cranberry juice-en enriched and cranberry pomace polyphenol-enriched soy protein isolate (CB-SPI and CBP- SPI) were tested against influenza viruses in vitro and in ovo and suggest CB-SPi and CBPs may have preventative and therapeutic potential against viral infections that cause diseases of the respiratory and gastro-intestinal tract. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020

2015 article

Novel value‐added uses for sweet potato juice and flour in polyphenol‐ and protein‐enriched functional food ingredients

Grace, M. H., Truong, A. N., Truong, V. D., Raskin, I., & Lila, M. A. (2015, April 9). Food Science & Nutrition, Vol. 3, pp. 415–424.

By: M. Grace n, A. Truong n, V. Truong n, I. Raskin* & M. Lila n

Contributors: M. Grace n, A. Truong n, V. Truong n, I. Raskin* & M. Lila n

author keywords: Anti-inflammatory; antioxidant; berries; polyphenols; stability; sweet potato
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Consumer Attitudes and Food Labeling; Antioxidant Activity and Oxidative Stress
TL;DR: Sensory evaluation of the ingredient matrices suggested potential uses for a wide range of functional food products, and anti-inflammatory and antioxidant fruit polyphenols with sweet potato functional constituents correlated well with total phenolic content. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

RNA-Seq analysis and annotation of a draft blueberry genome assembly identifies candidate genes involved in fruit ripening, biosynthesis of bioactive compounds, and stage-specific alternative splicing

Gigascience, 4.

By: V. Gupta, A. Estrada, I. Blakley, R. Reid, K. Patel, M. Meyer, S. Andersen, A. Brown, M. Lila, A. Loraine

Source: NC State University Libraries
Added: August 6, 2018

2015 article

Stability and immunogenicity of hypoallergenic peanut protein–polyphenol complexes during in vitro pepsin digestion

Plundrich, N. J., White, B. L., Dean, L. L., Davis, J. P., Foegeding, E. A., & Lila, M. A. (2015, January 1). Food & Function, Vol. 6, pp. 2145–2154.

By: N. Plundrich n, B. White*, L. Dean*, J. Davis*, E. Foegeding n & M. Lila n

MeSH headings : Antigens, Plant / chemistry; Antigens, Plant / immunology; Arachis / chemistry; Arachis / immunology; Digestion; Pepsin A / chemistry; Plant Proteins / chemistry; Plant Proteins / immunology; Polyphenols / chemistry; Polyphenols / immunology
topics (OpenAlex): Food Allergy and Anaphylaxis Research; Allergic Rhinitis and Sensitization; Contact Dermatitis and Allergies
TL;DR: It is suggested that peanut protein-polyphenol complexes may be less immunoreactive passing through the digestive tract in vivo, contributing to their attenuated allergenicity. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

A need for a transdisciplinary environment: the Plant Pathways Elucidation Project

Reid, R. W., Brouwer, C. R., Jackson, E. W., & Lila, M. A. (2014, July 30). Trends in Plant Science, Vol. 19, pp. 485–487.

By: R. Reid, C. Brouwer, E. Jackson* & M. Lila n

MeSH headings : Humans; Industry; Interdisciplinary Communication; Knowledge Bases; Metabolic Networks and Pathways; Plants / metabolism; Universities
topics (OpenAlex): CRISPR and Genetic Engineering; Transgenic Plants and Applications; Plant tissue culture and regeneration
TL;DR: The Plant Pathways Elucidation Project (P2EP) is a multi-institutional project that utilizes cutting-edge genomics research and related disciplines to provide greater understanding of the relation between plant-pathway products and human health. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Ajuga turkestanica increases Notch and Wnt signaling in aged skeletal muscle

European Review for Medical and Pharmacological Sciences, 18(17), 2584–2592.

By: S. Arthur, K. Zwetsloot, M. Lawrence, D. Nieman, M. Lila, M. Grace, R. Howden, I. Cooley ...

Source: NC State University Libraries
Added: August 6, 2018

2014 article

Anthocyanin profiling of wild maqui berries (Aristotelia chilensis [Mol.] Stuntz) from different geographical regions in Chile

Fredes, C., Yousef, G. G., Robert, P., Grace, M. H., Lila, M. A., Gómez, M., … Montenegro, G. (2014, February 4). Journal of the Science of Food and Agriculture, Vol. 94, pp. 2639–2648.

By: C. Fredes*, G. Yousef n, P. Robert*, M. Grace n, M. Lila n, M. Gómez*, M. Gebauer*, G. Montenegro*

Contributors: C. Fredes*, G. Yousef n, P. Robert*, M. Grace n, M. Lila n, M. Gómez*, M. Gebauer*, G. Montenegro*

author keywords: delphinidin-3; 5-diglucoside; delphinidin-3-glucoside; genetic diversity; maqui genotypes; ISSR-PCR
MeSH headings : Altitude; Anthocyanins / analysis; Anthocyanins / metabolism; Antioxidants / analysis; Antioxidants / metabolism; Chile; Chromatography, High Pressure Liquid; Climate; Elaeocarpaceae / chemistry; Elaeocarpaceae / genetics; Elaeocarpaceae / growth & development; Elaeocarpaceae / metabolism; Fruit / chemistry; Fruit / genetics; Fruit / growth & development; Fruit / metabolism; Genetic Markers; Genetic Variation; Limit of Detection; Phenols / analysis; Phenols / metabolism; Phylogeny; Spatio-Temporal Analysis; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Wilderness
topics (OpenAlex): Horticultural and Viticultural Research; Fermentation and Sensory Analysis; Phytochemicals and Antioxidant Activities
TL;DR: Three maqui genotypes exhibited significantly higher anthocyanin content than the others, as measured by pH differential method and high-performance liquid chromatography-mass spectrometry and significant genetic diversity was noted within each ecological population. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 article

Bioactive Capacity, Sensory Properties, and Nutritional Analysis of a Shelf Stable Protein-rich Functional Ingredient with Concentrated Fruit and Vegetable Phytoactives

Grace, M. H., Yousef, G. G., Esposito, D., Raskin, I., & Lila, M. A. (2014, October 30). Plant Foods for Human Nutrition, Vol. 69, pp. 372–378.

By: M. Grace n, G. Yousef n, D. Esposito n, I. Raskin* & M. Lila n

Contributors: M. Grace n, G. Yousef n, D. Esposito n, I. Raskin* & M. Lila n

author keywords: Muscadine; Kale; Protein isolate; Inflammatory biomarkers
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Anti-Inflammatory Agents / therapeutic use; Brassica / chemistry; Cannabis; Carotenoids / pharmacology; Carotenoids / therapeutic use; Chemokine CCL2 / metabolism; Diet; Dietary Proteins / analysis; Fruit / chemistry; Functional Food / analysis; Glucosinolates / pharmacokinetics; Glucosinolates / pharmacology; Humans; Inflammation / drug therapy; Inflammation / metabolism; Interleukin-6 / metabolism; Mice; Nutritive Value; Plant Preparations / pharmacology; Plant Preparations / therapeutic use; Polyphenols / pharmacology; Polyphenols / therapeutic use; Soybean Proteins; Taste; Vegetables / chemistry; Vitis / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Antioxidant Activity and Oxidative Stress; Biochemical Analysis and Sensing Techniques
TL;DR: Proximate analyses determined that fortification of the soy protein isolate with muscadine or kale bioactives resulted in elevated dietary fibers, total carbohydrates, and free sugars, but did not increase calories/100 g dry matrix compared to unfortified SPI. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 article

CAPITALIZING ON THE HEALTH BENEFITS OF BERRYFRUIT: SCIENCE VERSUS THE MARKETPLACE

Lila, M. A. (2014, August 1). Acta Horticulturae, Vol. 1048, pp. 123–128.

By: M. Lila n

topics (OpenAlex): Horticultural and Viticultural Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2014 article

Compounds leached from quinoa seeds inhibit matrix metalloproteinase activity and intracellular reactive oxygen species

Graf, B. L., Cheng, D. M., Esposito, D., Shertel, T., Poulev, A., Plundrich, N., … Raskin, I. (2014, December 11). International Journal of Cosmetic Science, Vol. 37, pp. 212–221.

By: B. Graf*, D. Cheng*, D. Esposito n, T. Shertel*, A. Poulev*, N. Plundrich n, D. Itenberg*, N. Dayan, M. Lila n, I. Raskin*

author keywords: ageing; cell culture; chemical analysis; oxidative damage; phytochemistry; phytoecdysteroid
MeSH headings : Cells, Cultured; Chenopodium quinoa / embryology; Chromatography, Liquid; Humans; Mass Spectrometry; Matrix Metalloproteinase 1 / drug effects; Matrix Metalloproteinase 1 / genetics; Monophenol Monooxygenase / antagonists & inhibitors; Protease Inhibitors / pharmacology; Reactive Oxygen Species / metabolism; Seeds / chemistry
topics (OpenAlex): Antioxidant Activity and Oxidative Stress; Transgenic Plants and Applications
TL;DR: This work aimed to determine the effect of QL and its chemically distinct fractions on five biochemical endpoints relevant to skin care applications: cell viability, matrix metalloproteinase (MMP) mRNA expression, MMP enzymatic activity, tyrosinase enzymatics activity and intracellular reactive oxygen species (ROS) production. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Concentrating Immunoprotective Phytoactive Compounds from Fruits and Vegetables into Shelf-stable Protein-rich Ingredients

Yousef, G. G., Grace, M. H., Medina, J. L. G., Neff, S., Guzman, I., Brown, A. F., … Lila, M. A. (2014, October 28). Plant Foods for Human Nutrition, Vol. 69, pp. 317–324.

By: G. Yousef n, M. Grace n, J. Medina n, S. Neff n, I. Guzman n, A. Brown n, I. Raskin*, M. Lila n

Contributors: G. Yousef n, M. Grace n, J. Medina n, S. Neff n, I. Guzman n, A. Brown n, I. Raskin*, M. Lila n

author keywords: Muscadine; Kale; Polyphenolics; Carotenoids; Glucosinolates; Protein isolate
MeSH headings : Brassica / chemistry; Carotenoids / analysis; Diet; Dietary Proteins; Food Handling; Fruit / chemistry; Functional Food; Glucosinolates / analysis; Humans; Immunologic Factors; Plant Extracts / chemistry; Polyphenols / analysis; Vegetables / chemistry; Vitis / chemistry
topics (OpenAlex): Moringa oleifera research and applications; Phytochemicals and Antioxidant Activities; Hibiscus Plant Research Studies
TL;DR: Neither total phenolics nor glucosinolates were significantly diminished even after long term storage at 4, 20, or 37 °C, whereas carotenoids degraded over time, particularly at higher temperatures. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 article

Cytotoxic Effects of Ellagitannins Isolated from Walnuts in Human Cancer Cells

Le, V., Esposito, D., Grace, M. H., Ha, D., Pham, A., Bortolazzo, A., … White, J. B. (2014, September 29). Nutrition and Cancer, Vol. 66, pp. 1304–1314.

By: V. Le*, D. Esposito n, M. Grace n, D. Ha*, A. Pham*, A. Bortolazzo*, Z. Bevens*, J. Kim* ...

Contributors: V. Le*, D. Esposito n, M. Grace n, D. Ha*, A. Pham*, A. Bortolazzo*, Z. Bevens*, J. Kim* ...

MeSH headings : 3T3 Cells; Animals; Apoptosis / drug effects; Cell Line, Tumor; Cyclin B1 / metabolism; Cytochromes c / metabolism; Diet; HeLa Cells; Humans; Hydrogen-Ion Concentration; Hydrolyzable Tannins / pharmacology; Juglans / chemistry; MCF-7 Cells; Mice; Mice, Nude; Mitochondria / drug effects; Nuts / chemistry; Plant Extracts / pharmacology
topics (OpenAlex): Nuts composition and effects; Antioxidant Activity and Oxidative Stress; Phytochemicals and Antioxidant Activities
TL;DR: The results suggest impairment of mitochondrial function and apoptosis as relevant mechanism of anticancer effects of the walnut extract as well as antimitogenic effects of walnuts. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 article

Efficient preparative isolation and identification of walnut bioactive components using high-speed counter-current chromatography and LC-ESI-IT-TOF-MS

Grace, M. H., Warlick, C. W., Neff, S. A., & Lila, M. A. (2014, March 1). Food Chemistry, Vol. 158, pp. 229–238.

By: M. Grace n, C. Warlick n, S. Neff n & M. Lila n

Contributors: M. Grace n, C. Warlick n, S. Neff n & M. Lila n

author keywords: Walnut; Jug Ions regia; Ellagitannins; High-speed counter-current; chromatography; ESI-MS/MS
MeSH headings : Chromatography, High Pressure Liquid / methods; Countercurrent Distribution / methods; Juglans / chemistry; Tandem Mass Spectrometry / methods
topics (OpenAlex): Chromatography in Natural Products; Food Quality and Safety Studies; Fermentation and Sensory Analysis
TL;DR: These results provided a foundation for in depth characterisation of walnut compounds and offered an efficient strategy for isolation of potentially health-relevant phytochemicals from walnuts. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 article

Inhibitory Effects of Wild Blueberry Anthocyanins and Other Flavonoids on Biomarkers of Acute and Chronic Inflammation in Vitro

Esposito, D., Chen, A., Grace, M. H., Komarnytsky, S., & Lila, M. A. (2014, January 8). Journal of Agricultural and Food Chemistry, Vol. 62, pp. 7022–7028.

By: D. Esposito n, A. Chen n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: D. Esposito n, A. Chen n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: Vaccinium angustifolium; lowbush blueberry; polyphenols; proanthocyanidins; chlorogenic acid
MeSH headings : Acute Disease; Animals; Anthocyanins / pharmacology; Base Sequence; Biomarkers / metabolism; Blueberry Plants / chemistry; Cell Line; Chromatography, High Pressure Liquid; Chronic Disease; DNA Primers; In Vitro Techniques; Inflammation / metabolism; Macrophages / drug effects; Macrophages / metabolism; Mice; Polymerase Chain Reaction
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Bioactive natural compounds; Bioactive Compounds in Plants
TL;DR: Among major polyphenols found in the wild blueberries, malvidin-3-glucoside was significantly more effective than epicatechin or chlorogenic acid in reducing the expression of pro-inflammatory genes in vitro. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease

Brain Research, 1555, 60–77.

By: K. Strathearn*, G. Yousef n, M. Grace n, S. Roy*, M. Tambe*, M. Ferruzzi*, Q. Wu*, J. Simon* ...

Contributors: K. Strathearn*, G. Yousef n, M. Grace n, S. Roy*, M. Tambe*, M. Ferruzzi*, Q. Wu*, J. Simon*, M. Lila n, J. Rochet*

author keywords: Anthocyanin; Microglial activation; Mitochondria; Parkinson's disease; Proanthocyanidin; Rotenone
MeSH headings : Animals; Anthocyanins / therapeutic use; Cells, Cultured; Dopaminergic Neurons / drug effects; Dopaminergic Neurons / metabolism; Mice; Microglia / drug effects; Mitochondria / drug effects; Mitochondria / metabolism; Neuroprotective Agents / therapeutic use; Parkinson Disease / drug therapy; Parkinson Disease / metabolism; Phytotherapy; Plant Extracts / therapeutic use; Proanthocyanidins / therapeutic use; Rotenone / toxicity; Tyrosine 3-Monooxygenase / metabolism
topics (OpenAlex): Parkinson's Disease Mechanisms and Treatments; Biochemical and biochemical processes; Phytochemicals and Antioxidant Activities
TL;DR: It is suggested that anthocyanin- and proanthocyanidin-rich botanical extracts may alleviate neurodegeneration in PD via enhancement of mitochondrial function. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2014 article

Novel Strategy To Create Hypoallergenic Peanut Protein–Polyphenol Edible Matrices for Oral Immunotherapy

Plundrich, N. J., Kulis, M., White, B. L., Grace, M. H., Guo, R., Burks, A. W., … Lila, M. A. (2014, April 24). Journal of Agricultural and Food Chemistry, Vol. 62, pp. 7010–7021.

By: N. Plundrich n, M. Kulis*, B. White*, M. Grace n, R. Guo*, A. Burks*, J. Davis*, M. Lila n

Contributors: N. Plundrich n, M. Kulis*, B. White*, M. Grace n, R. Guo*, A. Burks*, J. Davis*, M. Lila n

author keywords: basophil; cranberry; mouse model; peanut allergy; polyphenols
MeSH headings : Administration, Oral; Arachis / immunology; Arachis / metabolism; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Humans; Immunotherapy; Peanut Hypersensitivity / prevention & control; Plant Proteins / administration & dosage; Plant Proteins / immunology; Polyphenols / administration & dosage; Polyphenols / immunology; Spectroscopy, Fourier Transform Infrared
topics (OpenAlex): Food Allergy and Anaphylaxis Research; Eosinophilic Esophagitis; Viral gastroenteritis research and epidemiology
TL;DR: Polyphenol fortification of peanut flour resulted in a hypoallergenic matrix with reduced IgE binding and degranulation capacity, likely due to changes in protein secondary structure or masking of epitopes, suggesting potential applications for oral immunotherapy. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 article

Novel strategies for capturing health-protective mango phytochemicals in shelf stable food matrices

Guzman, I., Grace, M. H., Yousef, G. G., Raskin, I., & Lila, M. A. (2014, December 18). International Journal of Food Sciences and Nutrition, Vol. 66, pp. 175–185.

By: I. Guzman n, M. Grace n, G. Yousef n, I. Raskin* & M. Lila n

Contributors: I. Guzman n, M. Grace n, G. Yousef n, I. Raskin* & M. Lila n

author keywords: Carotenoids; fortified foods; polyphenols; protein-rich flour; vitamin A
MeSH headings : Africa; Arachis; Carbohydrates / analysis; Carotenoids / administration & dosage; Carotenoids / analysis; Diet; Dietary Proteins; Flour / analysis; Food Handling / methods; Food Preservation; Fruit / chemistry; Health; Helianthus; Humans; Malnutrition / prevention & control; Mangifera / chemistry; Phytochemicals / analysis; Plant Oils; Polyphenols / administration & dosage; Polyphenols / analysis; Rural Population; Soybeans; Sunflower Oil
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Ginkgo biloba and Cashew Applications; Postharvest Quality and Shelf Life Management
TL;DR: Cost-effective methods for concentration and stabilization of otherwise perishable mango fruit phytoactives into shelf stable high protein ingredients were developed to combat stunting (malnutrition) in rural Africa and capture the benefits of Otherwise perishable seasonal resources by complexing healthful proteins together with phy toactive compounds. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 article

Phlorotannins from Alaskan Seaweed Inhibit Carbolytic Enzyme Activity

Kellogg, J., Grace, M., & Lila, M. (2014, October 22). Marine Drugs, Vol. 12, pp. 5277–5294.

By: J. Kellogg n, M. Grace n & M. Lila n

Contributors: J. Kellogg n, M. Grace n & M. Lila n

author keywords: Alaska; seaweed; diabetes; glucosidase; hyperglycemia; amylase; type 2 diabetes mellitus; phlorotannin; polyphenol; ethnopharmacology
MeSH headings : Animals; Biological Factors / metabolism; Biological Factors / pharmacology; Carbohydrates; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Fucus / metabolism; Kinetics; Saccharomyces cerevisiae / metabolism; Seaweed / metabolism; Swine / metabolism; Tannins / metabolism; Tannins / pharmacology; alpha-Amylases / antagonists & inhibitors; alpha-Glucosidases / metabolism
topics (OpenAlex): Seaweed-derived Bioactive Compounds; Protein Hydrolysis and Bioactive Peptides; Fatty Acid Research and Health
TL;DR: It is suggested that coastal Alaskan seaweeds are sources of α-glucosidase and α-amylase inhibitory phlorotannins, and thus have potential to limit the release of sugar from carbohydrates and thus alleviate postprandial hyperglycemia. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 article

Quinoa seeds leach phytoecdysteroids and other compounds with anti-diabetic properties

Graf, B. L., Poulev, A., Kuhn, P., Grace, M. H., Lila, M. A., & Raskin, I. (2014, May 4). Food Chemistry, Vol. 163, pp. 178–185.

Contributors: B. Graf*, A. Poulev*, P. Kuhn*, M. Grace n, M. Lila n & I. Raskin*

author keywords: Ecdysterone; Flavonoids; Metabolic syndrome; Nutraceutical; Phytoecdysteroids
MeSH headings : Animals; Chenopodium quinoa / chemistry; Chromatography, Liquid; Ecdysterone / isolation & purification; Ecdysterone / pharmacology; Hypoglycemic Agents / isolation & purification; Male; Mice; Mice, Inbred C57BL; Seeds / chemistry
topics (OpenAlex): Seed and Plant Biochemistry; Microbial Metabolites in Food Biotechnology; Consumer Attitudes and Food Labeling
TL;DR: Leaching effectively releases and concentrates bioactive phytochemicals from quinoa seeds, providing an efficient means to produce a food-grade mixture that may be useful for anti-diabetic applications. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 article

STRESSED FOR SUCCESS: HOW THE BERRY'S WILD ORIGINS RESULT IN MULTIFACETED HEALTH PROTECTIONS

Lila, M. A., Kellogg, J., Grace, M. H., Yousef, G. G., Kraft, T. B., & Rogers, R. B. (2014, January 1). Acta Horticulturae, Vol. 1017, pp. 23–43.

By: M. Lila*, J. Kellogg*, M. Grace*, G. Yousef*, T. Kraft & R. Rogers

author keywords: elicitation; anthocyanins; proanthocyanidins; inflammation; metabolic syndrome
topics (OpenAlex): Food Security and Health in Diverse Populations; Public Health Policies and Education
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro

Waterman, C., Cheng, D. M., Rojas-Silva, P., Poulev, A., Dreifus, J., Lila, M. A., & Raskin, I. (2014, April 11). Phytochemistry, Vol. 103, pp. 114–122.

By: C. Waterman*, D. Cheng*, P. Rojas-Silva*, A. Poulev*, J. Dreifus*, M. Lila n, I. Raskin*

author keywords: Moringa oleifera; Moringaceae Chronic inflammation; Isothiocyanates; 4-[(alpha-L-rhamnosyloxy) benzyl]isothiocyanate; 4-[(4'-O-acetyl-alpha-L-rhamnosyloxy) benzyl]isothiocyanate
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Cell Line; Interleukin-1beta / metabolism; Isothiocyanates / chemistry; Isothiocyanates / pharmacology; Macrophages / drug effects; Macrophages / metabolism; Mice; Moringa oleifera; Nitric Oxide / metabolism; Nitric Oxide Synthase Type II / metabolism; Plant Extracts / chemistry; Plant Extracts / pharmacology; Plant Leaves / chemistry; Water / chemistry
topics (OpenAlex): Moringa oleifera research and applications; Genomics, phytochemicals, and oxidative stress
TL;DR: A potential for stable and concentrated moringa isothiocyanates, delivered in MC as a food-grade product, to alleviate low-grade inflammation associated with chronic diseases is suggested. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

The Protective Effects of a Polyphenol‐Enriched Protein Powder on Exercise‐Induced Susceptibility to Virus Infection

Ahmed, M., Henson, D. A., Sanderson, M. C., Nieman, D. C., Gillitt, N. D., & Lila, M. A. (2014, August 2). Phytotherapy Research, Vol. 28, pp. 1829–1836.

By: M. Ahmed*, D. Henson*, M. Sanderson*, D. Nieman*, N. Gillitt* & M. Lila n

author keywords: virus infection; polyphenols; green tea; blueberry extract
MeSH headings : Adult; Athletes; Dietary Supplements; Disease Susceptibility / physiopathology; Exercise; Female; HeLa Cells; Humans; Immune Tolerance / drug effects; Male; Middle Aged; Polyphenols / pharmacology; Running; Soybean Proteins; Tea; Vaccinium; Vesiculovirus; Virus Diseases / prevention & control; Young Adult
topics (OpenAlex): Exercise and Physiological Responses; Bee Products Chemical Analysis; Herbal Medicine Research Studies
TL;DR: It is indicated that polyphenol complexes containing blueberry and green tea have the potential to protect athletes from virus infections following rigorous exercise. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 article

Anthocyanins and proanthocyanidins from blueberry–blackberry fermented beverages inhibit markers of inflammation in macrophages and carbohydrate‐utilizing enzymes in vitro

Johnson, M. H., Mejia, E. G., Fan, J., Lila, M. A., & Yousef, G. G. (2013, March 25). Molecular Nutrition & Food Research, Vol. 57, pp. 1182–1197.

author keywords: Anthocyanin; Berry; Diabetes; Hydrolysable tannins; Inflammation; Proanthocyanidin
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Antioxidants / pharmacology; Beverages; Blueberry Plants / chemistry; Cell Line, Tumor; Cell Proliferation / drug effects; Fermentation; Fruit / chemistry; Glucosides / analysis; Inflammation / prevention & control; Lipopolysaccharides / adverse effects; Macrophages / drug effects; Macrophages / metabolism; Mice; NF-kappa B / genetics; NF-kappa B / metabolism; Plant Extracts / pharmacology; Polyphenols / pharmacology; Proanthocyanidins / pharmacology; Wine / analysis; alpha-Amylases / metabolism; alpha-Glucosidases / metabolism
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Microbial Metabolites in Food Biotechnology; Natural Antidiabetic Agents Studies
TL;DR: ANCs demonstrated that delphinidin-3-arabinoside effectively inactivated dipeptidyl peptidase-IV by binding with the lowest interaction energy (-3228 kcal/mol). (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Berry and citrus phenolic compounds inhibit dipeptidyl peptidase IV: Implications in diabetes management

Evidence-Based Complementary and Alternative Medicine.

By: J. Fan, M. Johnson, M. Lila, G. Yousef & E. Mejia

Source: NC State University Libraries
Added: August 6, 2018

2013 article

Bioactive polyphenols from muscadine grape and blackcurrant stably concentrated onto protein‐rich matrices for topical applications

Plundrich, N., Grace, M. H., Raskin, I., & Lila, M. A. (2013, April 24). International Journal of Cosmetic Science, Vol. 35, pp. 394–401.

By: N. Plundrich n, M. Grace n, I. Raskin* & M. Lila n

Contributors: N. Plundrich n, M. Grace n, I. Raskin* & M. Ann Lila n

author keywords: antimicrobial; blackcurrant; muscadine grape; polyphenols; topical applications; tyrosinase
MeSH headings : Polyphenols / administration & dosage; Polyphenols / pharmacology; Proteins / drug effects; Ribes / chemistry; Vitis / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; melanin and skin pigmentation; Skin Protection and Aging
TL;DR: Natural botanical agents that are antimicrobial, or that modulate skin hyperpigmentation via tyrosinase inhibition, are increasingly sought in the cosmetic industry. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 article

Biosynthesis of highly enriched 13C-lycopene for human metabolic studies using repeated batch tomato cell culturing with 13C-glucose

Moran, N. E., Rogers, R. B., Lu, C.-H., Conlon, L. E., Lila, M. A., Clinton, S. K., & Erdman, J. W. (2013, January 23). Food Chemistry, Vol. 139, pp. 631–639.

By: N. Moran*, R. Rogers*, C. Lu*, L. Conlon*, M. Lila n, S. Clinton*, J. Erdman*

author keywords: Carotenoids; Tracers; Lycopene; Tomato; Nutrition; Plant cell culture
MeSH headings : Biological Availability; Carbon Isotopes / metabolism; Carotenoids / biosynthesis; Cells, Cultured; Glucose / chemistry; Glucose / metabolism; Humans; Isotope Labeling; Lycopene; Solanum lycopersicum / chemistry; Solanum lycopersicum / metabolism
topics (OpenAlex): Enzyme Catalysis and Immobilization; Plant tissue culture and regeneration; Photosynthetic Processes and Mechanisms
TL;DR: An optimised acetone and hexane extraction led to a fourfold increase in lycopene recovery from cultures compared to a standard extraction and an optimised 9-day-long and 18- day-long labelling strategy developed based on glucose utilisation and lycopenes yields yielded (13)C-lycopene with 93% ( 13)C isotopic purity, and 55% of isotopomers were uniformly labelled. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 article

Chemical and in Vitro Assessment of Alaskan Coastal Vegetation Antioxidant Capacity

Kellogg, J., & Lila, M. A. (2013, October 22). Journal of Agricultural and Food Chemistry, Vol. 61, pp. 11025–11032.

By: J. Kellogg n & M. Lila n

author keywords: Alaska; seaweed; antioxidant; RAW 264.7 macrophages; radical oxygen species; phlorotannin; nitric oxide; total phenolic content
MeSH headings : Alaska; Animals; Antioxidants / analysis; Antioxidants / pharmacology; Cell Line; Cell Survival / drug effects; Fucus / chemistry; Mice; Phenols / chemistry; Phenols / pharmacology; Plant Extracts / analysis; Plant Extracts / pharmacology; Plantago / chemistry; Rhodophyta / chemistry; Seaweed / chemistry; Ulva / chemistry; Vegetables / chemistry
topics (OpenAlex): Seaweed-derived Bioactive Compounds; Marine and coastal plant biology; Plant Growth Enhancement Techniques
TL;DR: The results support the potential of Alaskan coastal vegetation, especially the brown algae, as natural sources of antioxidants for preventing oxidative degeneration and maintaining human health. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 article

Comparative Analysis of Phenolic Content and Profile, Antioxidant Capacity, and Anti-inflammatory Bioactivity in Wild Alaskan and Commercial Vaccinium Berries

Grace, M. H., Esposito, D., Dunlap, K. L., & Lila, M. A. (2013, November 12). Journal of Agricultural and Food Chemistry, Vol. 62, pp. 4007–4017.

By: M. Grace n, D. Esposito n, K. Dunlap* & M. Lila n

Contributors: M. Grace n, D. Esposito n, K. Dunlap* & M. Lila n

author keywords: Vaccinium vitis-idaea; V. uliginosum; V. macrocarpon; V. angustifolium; phenolics; antioxidant; anti-inflammatory
MeSH headings : Alaska; Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / pharmacology; Chromatography, High Pressure Liquid; Fruit / chemistry; Macrophages / drug effects; Macrophages / immunology; Mass Spectrometry; Mice; Phenols / chemistry; Plant Extracts / chemistry; Plant Extracts / pharmacology; Vaccinium / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Natural product bioactivities and synthesis; Antioxidant Activity and Oxidative Stress
TL;DR: A polyphenol-rich fraction from lowbush cranberry exhibited dose-dependent inhibition of LPS-elicited induction of IL-1β in RAW 2647 cells, indicative of strong anti-inflammatory activity, corroborate the historic use of wild Alaskan berries as medicinally important foods in Alaska Native communities. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 article

Concord Grape Pomace Polyphenols Complexed to Soy Protein Isolate Are Stable and Hypoglycemic in Diabetic Mice

Roopchand, D. E., Kuhn, P., Krueger, C. G., Moskal, K., Lila, M. A., & Raskin, I. (2013, November 8). Journal of Agricultural and Food Chemistry, Vol. 61, pp. 11428–11433.

author keywords: grape pomace; polyphenols; soy protein isolate; nutrition; hyperglycemia
MeSH headings : Animals; Blood Glucose; Chemical Fractionation / methods; Diabetes Mellitus, Experimental / drug therapy; Drug Stability; Hyperglycemia / drug therapy; Hyperglycemia / metabolism; Hypoglycemic Agents / pharmacology; Male; Mice; Mice, Inbred C57BL; Polyphenols / chemistry; Polyphenols / isolation & purification; Polyphenols / pharmacology; Proanthocyanidins / analysis; Soybean Proteins / chemistry; Soybean Proteins / pharmacology; Vitis / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Natural Antidiabetic Agents Studies; Phytoestrogen effects and research
TL;DR: GP-SPI allows the capture of grape pomace polyphenols in a protein-rich food matrix and may be useful as a functional food ingredient for the management of blood glucose levels. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 article

Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1)

Ribnicky, D. M., Roopchand, D. E., Oren, A., Grace, M., Poulev, A., Lila, M. A., … Raskin, I. (2013, July 25). Food Chemistry, Vol. 142, pp. 349–357.

By: D. Ribnicky*, D. Roopchand*, A. Oren*, M. Grace n, A. Poulev*, M. Lila n, R. Havenaar, I. Raskin*

Contributors: D. Ribnicky*, D. Roopchand*, A. Oren*, M. Grace n, A. Poulev*, M. Lila n, R. Havenaar, I. Raskin*

author keywords: Blueberry; Anthocyanins; Bioavailability; Bioaccessibility; Gastrointestinal model; TIM-1; Soybean flour; Nutrition
MeSH headings : Anthocyanins / metabolism; Anthocyanins / pharmacokinetics; Biological Availability; Blueberry Plants / metabolism; Cell Line; Dietary Fats / analysis; Dietary Fats / metabolism; Digestion; Fruit / metabolism; Gastrointestinal Tract / metabolism; Humans; Intestinal Absorption; Models, Biological; Soybean Proteins / chemistry; Soybean Proteins / metabolism
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Food composition and properties; Microbial Metabolites in Food Biotechnology
TL;DR: The TNO intestinal model (TIM-1) of the human upper gastrointestinal tract was used to compare intestinal absorption/bioaccessibility of blueberry anthocyanins under different digestive conditions, suggesting lipid-rich matrices selectively effect Anthocyanin bioaccessibility. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 article

Efficient Quantification of the Health-Relevant Anthocyanin and Phenolic Acid Profiles in Commercial Cultivars and Breeding Selections of Blueberries (Vaccinium spp.)

Yousef, G. G., Brown, A. F., Funakoshi, Y., Mbeunkui, F., Grace, M. H., Ballington, J. R., … Lila, M. A. (2013, May 2). Journal of Agricultural and Food Chemistry, Vol. 61, pp. 4806–4815.

Contributors: G. Yousef*, A. Brown n, Y. Funakoshi n, F. Mbeunkui n, M. Grace n, J. Ballington n, A. Loraine*, M. Lila n

author keywords: anthocyanins; chlorogenic acid; blueberry; HPLC-DAD-MS; Vaccinium spp.; freeze-drying; health benefits
MeSH headings : Anthocyanins / analysis; Blueberry Plants / chemistry; Breeding; Chromatography, High Pressure Liquid / methods; Food, Preserved / analysis; Frozen Foods / analysis; Fruit / chemistry; Genotype; Glucosides / analysis; Health Promotion; Humans; Hydroxybenzoates / analysis; Plant Extracts / chemistry; Species Specificity; Tandem Mass Spectrometry / methods
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Berry genetics and cultivation research; Horticultural and Viticultural Research
TL;DR: An improved protocol was developed for the accurate, efficient, and rapid comparative screening for large blueberry sample sets and different genotypes frequently had comparable overall levels of total anthocyanins and phenolic acids, but differed dramatically in individual profiles of compounds. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 article

Food-compatible method for the efficient extraction and stabilization of cranberry pomace polyphenols

Roopchand, D. E., Krueger, C. G., Moskal, K., Fridlender, B., Lila, M. A., & Raskin, I. (2013, June 21). Food Chemistry, Vol. 141, pp. 3664–3669.

By: D. Roopchand*, C. Krueger*, K. Moskal*, B. Fridlender*, M. Lila n & I. Raskin*

author keywords: Cranberry pomace; Polyphenols; Proanthocyanidins; Anthocyanins; Soy protein isolate
MeSH headings : Chemical Fractionation / methods; Fruit / chemistry; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Polyphenols / chemistry; Polyphenols / isolation & purification; Vaccinium macrocarpon / chemistry; Waste Products / analysis
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Phytoestrogen effects and research; Microbial Metabolites in Food Biotechnology
TL;DR: The extraction and stabilization of cranberry pomace polyphenols using SPI provides an innovative approach for utilizing pomACE in the development of novel food ingredients. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Influence of a polyphenol-enriched protein powder on exercise-induced inflammation and oxidative stress in athletes: A randomized trial using a metabolomics approach

PLoS One, 8(8).

By: D. Nieman, N. Gillitt, A. Knab, R. Shanely, K. Pappan, F. Jin, M. Lila

Source: NC State University Libraries
Added: August 6, 2018

2013 article

Leishmanicidal activity of a daucane sesquiterpene isolated fromEryngium foetidum

Rojas-Silva, P., Graziose, R., Vesely, B., Poulev, A., Mbeunkui, F., Grace, M. H., … Raskin, I. (2013, October 23). Pharmaceutical Biology, Vol. 52, pp. 398–401.

Contributors: P. Rojas-Silva*, R. Graziose*, B. Vesely*, A. Poulev*, F. Mbeunkui n, M. Grace n, D. Kyle*, M. Lila n, I. Raskin*

author keywords: Apiaceae; bioassay guided fractionation; cytotoxicity; leishmaniasis; LC-MS; NMR; sesquiterpenoids
MeSH headings : Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / isolation & purification; Antiprotozoal Agents / pharmacology; Cell Line; Chromatography / methods; Chromatography, High Pressure Liquid / methods; Eryngium / chemistry; Inhibitory Concentration 50; Leishmania / drug effects; Leishmania donovani / drug effects; Magnetic Resonance Spectroscopy / methods; Mass Spectrometry / methods; Myoblasts / drug effects; Myoblasts / metabolism; Myoblasts, Skeletal / drug effects; Myoblasts, Skeletal / metabolism; Plant Components, Aerial; Rats; Sesquiterpenes / administration & dosage; Sesquiterpenes / isolation & purification; Sesquiterpenes / pharmacology; Toxicity Tests
topics (OpenAlex): Research on Leishmaniasis Studies; Insect Pest Control Strategies; Phytochemical compounds biological activities
TL;DR: The bioassay-guided fractionation with the leishmanicidal and cytotoxicity activities of two compounds isolated for the first time from an Eryngium species were presented. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 article

Phytochemical changes in phenolics, anthocyanins, ascorbic acid, and carotenoids associated with sweetpotato storage and impacts on bioactive properties

Grace, M. H., Yousef, G. G., Gustafson, S. J., Truong, V.-D., Yencho, G. C., & Lila, M. A. (2013, September 5). Food Chemistry, Vol. 145, pp. 717–724.

By: M. Grace n, G. Yousef n, S. Gustafson n, V. Truong n, G. Yencho n & M. Lila n

Contributors: M. Grace n, G. Yousef n, S. Gustafson n, V. Truong n, G. Yencho n & M. Lila n

author keywords: Sweetpotato; Phenolics; Carotenoids; Antioxidant activity; Storage; Postharvest
MeSH headings : Anthocyanins / analysis; Anthocyanins / isolation & purification; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / isolation & purification; Antioxidants / chemistry; Antioxidants / isolation & purification; Ascorbic Acid / analysis; Ascorbic Acid / isolation & purification; Carotenoids / analysis; Carotenoids / isolation & purification; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Food Storage; Genotype; Humans; Ipomoea batatas / chemistry; Ipomoea batatas / genetics; Ipomoea batatas / metabolism; Lipopolysaccharides; Phenols / analysis; Phenols / isolation & purification; Plant Extracts / chemistry; Reactive Oxygen Species / metabolism; Temperature; Time Factors
topics (OpenAlex): Postharvest Quality and Shelf Life Management; Phytochemicals and Antioxidant Activities; Antioxidant Activity and Oxidative Stress
TL;DR: Gradual changes in sweetpotato phytochemical content and antioxidant and anti-inflammatory capacity were noted during normal long-term storage, but the specific effects were genotype-dependent. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 article

Serum Metabolic Signatures Induced By a Three-Day Intensified Exercise Period Persist After 14 h of Recovery in Runners

Nieman, D. C., Shanely, R. A., Gillitt, N. D., Pappan, K. L., & Lila, M. A. (2013, August 28). Journal of Proteome Research, Vol. 12, pp. 4577–4584.

By: D. Nieman*, R. Shanely*, N. Gillitt*, K. Pappan* & M. Lila n

author keywords: metabolomics; running; lipids; amino acids; carnitines
MeSH headings : Adult; Amino Acids / blood; Female; Gas Chromatography-Mass Spectrometry; Humans; Lipid Metabolism; Lipids / blood; Male; Metabolome; Middle Aged; Physical Exertion; Running / physiology; Young Adult
topics (OpenAlex): Metabolomics and Mass Spectrometry Studies; Adipose Tissue and Metabolism; Muscle metabolism and nutrition
TL;DR: Runners experienced a profound systemic shift in blood metabolites related to energy production especially from the lipid super pathway following 3 days of heavy exertion that was not fully restored to pre-exercise levels after 14 h recovery. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 article

Stable Binding of Alternative Protein-Enriched Food Matrices with Concentrated Cranberry Bioflavonoids for Functional Food Applications

Grace, M. H., Guzman, I., Roopchand, D. E., Moskal, K., Cheng, D. M., Pogrebnyak, N., … Lila, M. A. (2013, June 21). Journal of Agricultural and Food Chemistry, Vol. 61, pp. 6856–6864.

By: M. Grace n, I. Guzman n, D. Roopchand*, K. Moskal*, D. Cheng*, N. Pogrebnyak*, I. Raskin*, A. Howell*, M. Lila n

Contributors: M. Grace n, I. Guzman n, D. Roopchand*, K. Moskal*, D. Cheng*, N. Pogrebnyak*, I. Raskin*, A. Howell*, M. Lila n

author keywords: A-type proanthocyanidins; polyphenols; Vaccinium macrocarpon; antiadhesion; antimicrobial; shelf stability
MeSH headings : Anthocyanins / analysis; Anti-Bacterial Agents / administration & dosage; Arachis / chemistry; Beverages / analysis; Cannabis / chemistry; Dietary Proteins / metabolism; Flavonoids / metabolism; Food, Fortified; Fruit / chemistry; Functional Food; Plant Proteins / metabolism; Polyphenols / metabolism; Proanthocyanidins / analysis; Soybean Proteins / metabolism; Urinary Tract Infections / prevention & control; Vaccinium macrocarpon / chemistry
topics (OpenAlex): Phytoestrogen effects and research; Food composition and properties; Proteins in Food Systems
TL;DR: Nutritional and sensory analyses indicated that the targeted CB-matrix combinations have high potential for incorporation in functional food formulations. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 article

Antiparasitic compounds from Cornus florida L. with activities against Plasmodium falciparum and Leishmania tarentolae

Graziose, R., Rojas-Silva, P., Rathinasabapathy, T., Dekock, C., Grace, M. H., Poulev, A., … Raskin, I. (2012, May 15). Journal of Ethnopharmacology, Vol. 142, pp. 456–461.

By: R. Graziose*, P. Rojas-Silva*, T. Rathinasabapathy*, C. Dekock*, M. Grace n, A. Poulev*, M. Lila n, P. Smith*, I. Raskin*

Contributors: R. Graziose*, P. Rojas-Silva*, T. Rathinasabapathy, C. Dekock*, M. Grace n, A. Poulev*, M. Ann Lila n, P. Smith*, I. Raskin*

author keywords: Cornus; Antiplasmodial; Antileishmanial; Malaria; Cytotoxicity; Triterpene; Betulinic acid
MeSH headings : Animals; Antimalarials / isolation & purification; Antimalarials / pharmacology; Cell Line; Cornus / chemistry; Inhibitory Concentration 50; Leishmania / drug effects; Leishmaniasis / drug therapy; Muscle, Skeletal / drug effects; Myoblasts / drug effects; Phytotherapy; Plant Bark; Plant Extracts / chemistry; Plant Extracts / pharmacology; Plant Extracts / therapeutic use; Plasmodium falciparum / drug effects; Rats; Trypanocidal Agents / isolation & purification; Trypanocidal Agents / pharmacology; Trypanocidal Agents / therapeutic use
topics (OpenAlex): Research on Leishmaniasis Studies; Natural product bioactivities and synthesis; Phytochemical compounds biological activities
TL;DR: The compounds isolated in this study, while displaying moderate in vitro antiplasmodial activity, do not fully support the historical importance of C. florida as an antimalarial remedy in North America. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 article

Antiplasmodial activity of cucurbitacin glycosides from Datisca glomerata (C. Presl) Baill

Graziose, R., Grace, M. H., Rathinasabapathy, T., Rojas-Silva, P., Dekock, C., Poulev, A., … Raskin, I. (2012, December 24). Phytochemistry, Vol. 87, pp. 78–85.

By: R. Graziose*, M. Grace n, T. Rathinasabapathy*, P. Rojas-Silva*, C. Dekock*, A. Poulev*, M. Lila n, P. Smith*, I. Raskin*

Contributors: R. Graziose*, M. Grace n, T. Rathinasabapathy, P. Rojas-Silva*, C. Dekock*, A. Poulev*, M. Lila n, P. Smith*, I. Raskin*

author keywords: Datisca glomerata; Cucurbitales; Datiscaceae; Durango root; Bioassay guided fractionation; Cucurbitacin; Antimalarial; Antileishmanial; Cytotoxicity
MeSH headings : Animals; Antimalarials / chemistry; Antimalarials / pharmacology; CHO Cells; Cell Line; Cricetinae; Glycosides / chemistry; Glycosides / pharmacology; Magnoliopsida / chemistry; Molecular Structure; Plants, Medicinal / chemistry; Plasmodium falciparum / drug effects; Rats; Triterpenes / chemistry; Triterpenes / pharmacology
topics (OpenAlex): Advances in Cucurbitaceae Research; Traditional and Medicinal Uses of Annonaceae; Carbohydrate Chemistry and Synthesis
TL;DR: The traditionally used antimalarial plant, Datisca glomerata (C. Presl) Baill, was subjected to antiplasmodial assay guided fractionation, which led to the isolation of seven cucurbitacin glycosides, datiscosides I-O, along with two known compounds from the aerial parts of D. glomersata, which displayed cytotoxicity against L6 but not CHO mammalian cells. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

Antiplasmodial activity of the ethnobotanical plant Cassia fistula

Natural Product Communications, 7(10), 1263–1266.

By: M. Grace, C. Lategan, R. Graziose, P. Smith, I. Raskin & M. Lila

Source: NC State University Libraries
Added: August 6, 2018

2012 article

Biochemical Analysis and in Vivo Hypoglycemic Activity of a Grape Polyphenol–Soybean Flour Complex

Roopchand, D. E., Kuhn, P., Poulev, A., Oren, A., Lila, M. A., Fridlender, B., & Raskin, I. (2012, April 2). Journal of Agricultural and Food Chemistry, Vol. 60, pp. 8860–8865.

By: D. Roopchand*, P. Kuhn*, A. Poulev*, A. Oren*, M. Lila n, B. Fridlender*, I. Raskin*

author keywords: Concord grape juice; defatted soy flour; anthocyanins; proanthocyanidins; polyphenols; hypoglycemic; diabetes
MeSH headings : Adsorption; Animals; Blood Glucose / metabolism; Flour / analysis; Humans; Hydrogen-Ion Concentration; Hyperglycemia / drug therapy; Hyperglycemia / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / chemistry; Male; Mice; Mice, Inbred C57BL; Polyphenols / administration & dosage; Polyphenols / chemistry; Soybeans / chemistry; Vitis / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Food composition and properties; Phytoestrogen effects and research
TL;DR: Grape polyphenol-enriched DSF can provide a high-protein, low-sugar ingredient for delivery of concentrated grape polyphenolics and was able to significantly lower blood glucose levels in hyperglycemic C57BL/6J mice. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 article

Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice

Roopchand, D. E., Kuhn, P., Rojo, L. E., Lila, M. A., & Raskin, I. (2012, December 4). Pharmacological Research, Vol. 68, pp. 59–67.

author keywords: Metabolic syndrome; Diabetes; Blueberry; Soybean; Anthocyanins; Polyphenols
MeSH headings : Animals; Anthocyanins / pharmacology; Anthocyanins / therapeutic use; Blueberry Plants; Cell Line; Cell Line, Tumor; Cholesterol / blood; Flour; Glucose / metabolism; Hyperglycemia / drug therapy; Hyperglycemia / metabolism; Hypoglycemic Agents / pharmacology; Hypoglycemic Agents / therapeutic use; Male; Mice; Mice, Inbred C57BL; Myoblasts / metabolism; Polyphenols / pharmacology; Polyphenols / therapeutic use; Rats; Soybeans; Weight Gain / drug effects
topics (OpenAlex): Phytoestrogen effects and research; Natural Antidiabetic Agents Studies; Biochemical effects in animals
TL;DR: The results indicate that delivery of blueberry polyphenols stabilized in a high-protein food matrix may be useful for the dietary management of pre-diabetes and/or diabetes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 article

Comparison of Health‐Relevant Flavonoids in Commonly Consumed Cranberry Products

Grace, M. H., Massey, A. R., Mbeunkui, F., Yousef, G. G., & Lila, M. A. (2012, July 2). Journal of Food Science, Vol. 77, pp. H176–183.

By: M. Grace n, A. Massey, F. Mbeunkui*, G. Yousef* & M. Lila*

Contributors: M. Grace n, A. Massey, F. Mbeunkui*, G. Yousef* & M. Lila*

author keywords: anthocyanins; cranberry; flavonoids; proanthocyanidins; processing
MeSH headings : Anthocyanins / analysis; Beverages; Biflavonoids / analysis; Catechin / analysis; Chromatography, High Pressure Liquid; Flavonoids / analysis; Food Handling / methods; Freeze Drying; Fruit / chemistry; Plant Extracts / analysis; Proanthocyanidins / analysis; Vaccinium macrocarpon / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Horticultural and Viticultural Research; Fermentation and Sensory Analysis
TL;DR: As cranberry juices and other products are increasingly consumed for their recognized health benefits (including prophylaxis against urinary tract infection), it is relevant to consider how various degrees of commercial and home processing can alter innate levels of the biologically active flavonoids characteristic to the intact fruits. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

Continuous Infusion of 20-Hydroxyecdysone Increased Mass of Triceps Brachii in C57BL/6 Mice

Phytotherapy Research, 27(1), 107–111.

By: D. Cheng*, L. Kutzler*, D. Boler*, J. Drnevich*, J. Killefer* & M. Lila*

author keywords: 20-hydroxyecdysone; infusion; mice; microarray; phytoecdysteroids; skeletal muscle
MeSH headings : Anabolic Agents / pharmacology; Animals; Ecdysterone / pharmacology; Gene Expression; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal / drug effects; Muscle, Skeletal / physiology; Oligonucleotide Array Sequence Analysis; Organ Size; Transcriptome
topics (OpenAlex): Neurobiology and Insect Physiology Research; Insect Utilization and Effects; Antioxidant Activity and Oxidative Stress
TL;DR: Overall, the data suggest that 20E does not have potent anabolic properties, however, a muscle‐specific increase was observed and genes were identified to provide an explanation for the muscle accretion. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021

2012 journal article

Cucurbitacin glycosides from Datisca glomerata with antiplasmodial activity

Planta Medica, 78(11).

By: R. Graziose*, M. Grace n, T. Rathinasabapathy*, P. Rojas-Silva*, C. Dekock*, A. Poulev*, M. Lila n, P. Smith*, I. Raskin*

topics (OpenAlex): Advances in Cucurbitaceae Research; Agricultural Practices and Plant Genetics; Papaya Research and Applications
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2012 conference paper

Cucurbitacin glycosides from Datisca glomerata with antiplasmodial activity

Planta Medica, 78(11), 1245–1245.

By: R. Graziose, M. Grace, T. Rathinasabapathy, P. Rojas-Silva, C. Dekock, A. Poulev, M. Lila, P. Smith, I. Raskin

Source: NC State University Libraries
Added: August 6, 2018

2012 article

In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix

Cheng, D. M., Kuhn, P., Poulev, A., Rojo, L. E., Lila, M. A., & Raskin, I. (2012, July 14). Food Chemistry, Vol. 135, pp. 2994–3002.

By: D. Cheng*, P. Kuhn*, A. Poulev*, L. Rojo*, M. Lila n & I. Raskin*

author keywords: Cinnamomum burmannii; Cinnamon; Diabetes; Fasting blood glucose; Glucose production
MeSH headings : Animals; Cell Line; Cinnamomum zeylanicum / chemistry; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / enzymology; Diabetes Mellitus, Type 2 / genetics; Diabetes Mellitus, Type 2 / metabolism; Glucose / metabolism; Glucose-6-Phosphatase / genetics; Glucose-6-Phosphatase / metabolism; Humans; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / pharmacology; Male; Mice; Mice, Inbred C57BL; Phosphoenolpyruvate Carboxykinase (ATP) / genetics; Phosphoenolpyruvate Carboxykinase (ATP) / metabolism; Plant Extracts / administration & dosage; Plant Extracts / pharmacology; Polyphenols / administration & dosage; Polyphenols / pharmacology; Rats; Soy Foods / analysis
topics (OpenAlex): Natural Antidiabetic Agents Studies; Microbial Metabolites in Food Biotechnology; Metabolism, Diabetes, and Cancer
TL;DR: CE and cinnamon polyphenol-enriched defatted soy flour (CDSF) were effective in acutely lowering fasting blood glucose levels in diet induced obese hyperglycemic mice at 300 and 600 mg/kg, respectively. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 article

Isolation and characterization of flavonols from blackcurrant by high‐performance counter‐current chromatography and electrospray ionization tandem mass spectrometry

Mbeunkui, F., Grace, M. H., Yousef, G. G., & Lila, M. A. (2012, July 1). Journal of Separation Science, Vol. 35, pp. 1682–1689.

By: F. Mbeunkui n, M. Grace n, G. Yousef n & M. Lila n

Contributors: F. Mbeunkui n, M. Grace n, G. Yousef n & M. Ann Lila n

author keywords: Blackcurrant (Ribes nigrum); Flavonols; High-performance counter-current chromatography; Liquid chromatography with tandem mass spectrometry
MeSH headings : Countercurrent Distribution / methods; Flavonols / chemistry; Flavonols / isolation & purification; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Ribes / chemistry; Spectrometry, Mass, Electrospray Ionization / methods
topics (OpenAlex): Chromatography in Natural Products; Phytochemicals and Antioxidant Activities; Food Quality and Safety Studies
TL;DR: The results of these experiments demonstrated that high-performance counter-current chromatography along with ESI-MS(n) is a sensitive, selective, and effective technology for isolation and characterization of minor constituents from a complex mixture. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

Seeking novel Leishmanicidal natural products from common medicinal plants, the example of Eryngium foetidum L

Planta Medica, 78(11).

By: P. Rojas-Silva*, R. Graziose*, A. Poulev*, F. Mbeunkui n, M. Grace n, M. Lila n, I. Raskin*

topics (OpenAlex): Research on Leishmaniasis Studies
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2012 conference paper

Seeking novel Leishmanicidal natural products from common medicinal plants, the example of Eryngium foetidum L

Planta Medica, 78(11), 1132–1132.

By: P. Rojas-Silva, R. Graziose, A. Poulev, F. Mbeunkui, M. Grace, M. Lila, I. Raskin

Source: NC State University Libraries
Added: August 6, 2018

2011 article

Complementary Approaches To Gauge the Bioavailability and Distribution of Ingested Berry Polyphenolics

Lila, M. A., Ribnicky, D. M., Rojo, L. E., Rojas-Silva, P., Oren, A., Havenaar, R., … al. (2011, December 6). Journal of Agricultural and Food Chemistry, Vol. 60, pp. 5763–5771.

By: M. Lila n, D. Ribnicky*, L. Rojo*, P. Rojas-Silva*, A. Oren*, R. Havenaar*, E. Janle*, I. Raskin* ...

Contributors: M. Lila n, D. Ribnicky*, L. Rojo*, P. Rojas-Silva*, A. Oren*, R. Havenaar*, E. Janle*, I. Raskin*, G. Yousef n, M. Grace n

author keywords: bioavailability; bioaccessibility; radiolabeling; artificial gastrointestinal tract
MeSH headings : Absorption; Animals; Anthocyanins / analysis; Anthocyanins / pharmacokinetics; Biological Availability; Blueberry Plants / chemistry; Carbon Isotopes / analysis; Carbon Isotopes / pharmacokinetics; Cell Line; Computer Simulation; Fruit / chemistry; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / metabolism; Humans; Models, Biological; Phytochemicals / analysis; Phytochemicals / pharmacokinetics; Polyphenols / analysis; Polyphenols / pharmacokinetics; Rats; Vitis / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Botanical Research and Applications; Fermentation and Sensory Analysis
TL;DR: Two different strategies for investigating the likely fate, after ingestion, of natural, bioactive berry constituents (anthocyanins and other non-nutritive flavonoids) are compared. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2011 article

Efficient sorption of polyphenols to soybean flour enables natural fortification of foods

Roopchand, D. E., Grace, M. H., Kuhn, P., Cheng, D. M., Plundrich, N., Poulev, A., … al. (2011, October 2). Food Chemistry, Vol. 131, pp. 1193–1200.

By: D. Roopchand*, M. Grace n, P. Kuhn*, D. Cheng*, N. Plundrich n, A. Poulev*, A. Howell*, B. Fridlender* ...

Contributors: D. Roopchand*, M. Grace n, P. Kuhn*, D. Cheng*, N. Plundrich n, A. Poulev*, A. Howell*, B. Fridlender*, M. Lila n, I. Raskin*

topics (OpenAlex): Phytochemicals and Antioxidant Activities; Food composition and properties; Microbial Metabolites in Food Biotechnology
TL;DR: It is demonstrated that defatted soybean flour (DSF) can sorb polyphenols from blueberry and cranberry juices while separating them from sugars, providing a means to create protein-rich food ingredients containing concentrated plant bioactives without excess sugars, fats and water that can be incorporated in a variety of scientifically validated functional foods and dietary supplements. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018

2011 journal article

In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis)

Food Chemistry, 131(2), 387–396.

By: L. Rojo, D. Ribnicky, S. Logendra, A. Poulev, P. Rojas-Silva, P. Kuhn, R. Dorn, M. Grace n ...

Contributors: L. Rojo, D. Ribnicky, S. Logendra, A. Poulev, P. Rojas-Silva, P. Kuhn, R. Dorn, M. Grace n, M. Lila n, I. Raskin

author keywords: Dietary anthocyanins; Metabolic syndrome; Glucose metabolism; Maqui Berry
topics (OpenAlex): Natural Antidiabetic Agents Studies; Phytochemicals and Antioxidant Activities; Bioactive natural compounds
TL;DR: It is observed that oral administration of ANC improved fasting blood glucose levels and glucose tolerance in hyperglycaemic obese C57BL/6J mice fed a high fat diet and D3S5G also increased glucose uptake in L6 myotubes and is at least partially responsible for ANC's anti-diabetic properties. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018

2011 article

In vitro antiplasmodial activity of indole alkaloids from the stem bark of Geissospermum vellosii

Mbeunkui, F., Grace, M. H., Lategan, C., Smith, P. J., Raskin, I., & Lila, M. A. (2011, December 6). Journal of Ethnopharmacology, Vol. 139, pp. 471–477.

By: F. Mbeunkui n, M. Grace n, C. Lategan*, P. Smith*, I. Raskin* & M. Lila n

Contributors: F. Mbeunkui n, M. Grace n, C. Lategan*, P. Smith*, I. Raskin* & M. Lila n

author keywords: Geissospermum vellosii; Apocynaceae; Indole alkaloids; Antiplasmodial activity; Malaria
MeSH headings : Animals; Antimalarials / chemistry; Antimalarials / isolation & purification; Antimalarials / pharmacology; Antimalarials / toxicity; Apocynaceae / chemistry; CHO Cells; Cell Survival / drug effects; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Indole Alkaloids / chemistry; Indole Alkaloids / isolation & purification; Indole Alkaloids / pharmacology; Indole Alkaloids / toxicity; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Parasitic Sensitivity Tests; Plant Bark; Plants, Medicinal; Plasmodium falciparum / drug effects
topics (OpenAlex): Chemical synthesis and alkaloids; Alkaloids: synthesis and pharmacology; Traditional and Medicinal Uses of Annonaceae
TL;DR: Evidence is provided to support the use of Geissospermum vellosii as an antimalarial agent, as used by the native populations, as part of the ongoing investigations of new bioactive compounds with activity against malaria parasites. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2011 journal article

Isolation and identification of antiplasmodial N-alkylamides from Spilanthes acmella flowers using centrifugal partition chromatography and ESI-IT-TOF-MS

Journal of Chromatography B, 879(21), 1886–1892.

By: F. Mbeunkui n, M. Grace n, C. Lategan*, P. Smith*, I. Raskin* & M. Lila n

Contributors: F. Mbeunkui n, M. Grace n, C. Lategan*, P. Smith*, I. Raskin* & M. Lila n

author keywords: Centrifugal partition chromatography; N-alkylamides; Antiplasmodial activity
MeSH headings : Amides / chemistry; Amides / isolation & purification; Amides / pharmacology; Animals; Antimalarials / chemistry; Antimalarials / isolation & purification; Antimalarials / pharmacology; Asteraceae / chemistry; CHO Cells; Cell Survival / drug effects; Centrifugation; Chromatography, Liquid / methods; Cricetinae; Cricetulus; Flowers / chemistry; Nuclear Magnetic Resonance, Biomolecular; Plasmodium falciparum / drug effects; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization / methods
topics (OpenAlex): Herbal Medicine Research Studies; Bioactive Compounds and Antitumor Agents; Pharmacological Effects of Natural Compounds
TL;DR: A systematic approach for investigating a suitable centrifugal partition chromatography (CPC) solvent system for N-alkylamides separation was reported, and CPC fractions demonstrated significantly higher antiplasmodial activity compared to corresponding purified N-alkinglamides, thus suggesting that interactions between these N-alklamides may potentiate antiplAsmodial bioactivity. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Isolation and structural elucidation of indole alkaloids from Geissospermum vellosii by mass spectrometry

Journal of Chromatography B, 885-886, 83–89.

By: F. Mbeunkui n, M. Grace n & M. Lila n

Contributors: F. Mbeunkui n, M. Grace n & M. Lila n

author keywords: Electrospray ionization tandem mass spectrometry; High performance counter-current chromatography; Indole alkaloids; Structural elucidation
MeSH headings : Apocynaceae / chemistry; Chromatography, High Pressure Liquid / methods; Countercurrent Distribution / methods; Indole Alkaloids / chemistry; Indole Alkaloids / isolation & purification; Molecular Conformation; Plant Bark / chemistry; Spectrometry, Mass, Electrospray Ionization / methods; Tandem Mass Spectrometry / methods
topics (OpenAlex): Chromatography in Natural Products; Natural product bioactivities and synthesis; Ginseng Biological Effects and Applications
TL;DR: The results of the experiments demonstrated that the combination of high performance counter current chromatography and ESI-MS(n) is a sensitive, selective and effective approach for rapid isolation and characterization of alkaloids from G. vellosii. (via Semantic Scholar)
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Sources: Crossref, NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018

2011 article

Promoting Wellness in Alaskan Villages: Integrating Traditional Knowledge and Science of Wild Berries

Flint, C. G., Robinson, E. S., Kellogg, J., Ferguson, G., BouFajreldin, L., Dolan, M., … Lila, M. A. (2011, June 1). EcoHealth, Vol. 8, pp. 199–209.

By: C. Flint*, E. Robinson*, J. Kellogg n, G. Ferguson*, L. BouFajreldin*, M. Dolan*, I. Raskin*, M. Lila n

author keywords: traditional ecological knowledge; wild berries; environmental change; participatory research; youth; health; community wellness
MeSH headings : Alaska; Alcoholism / ethnology; Analysis of Variance; Climate Change; Community-Based Participatory Research; Environmental Pollution / adverse effects; Ethnobotany / methods; Feeding Behavior / ethnology; Focus Groups; Fruit / chemistry; Fruit / physiology; Health Knowledge, Attitudes, Practice / ethnology; Health Promotion / methods; Humans; Indians, North American; Interviews as Topic; Inuit; Social Behavior
topics (OpenAlex): Indigenous Studies and Ecology; Indigenous Health, Education, and Rights; Urban Agriculture and Sustainability
TL;DR: Multiple berry species were found to have powerful bioactive health properties for ameliorating metabolic syndrome as well as importance for community wellness and suggest the importance of incorporating locally available foods and socio-cultural traditions into community wellness programming. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems

Food & Function, 2(5), 235.

By: S. Barnes*, J. Prasain*, T. D'Alessandro*, A. Arabshahi*, N. Botting*, M. Lila n, G. Jackson*, E. Janle*, C. Weaver*

MeSH headings : Animals; Biological Availability; Food; Genistein / analysis; Genistein / metabolism; Glucuronides / analysis; Glucuronides / metabolism; Glycosides / analysis; Glycosides / metabolism; Humans; Intestinal Mucosa / metabolism; Isoflavones / analysis; Isoflavones / metabolism; Liver / metabolism; Mass Spectrometry; Polyphenols / analysis; Polyphenols / metabolism
topics (OpenAlex): Phytoestrogen effects and research; Phytochemicals and Antioxidant Activities; Tea Polyphenols and Effects
TL;DR: Critical questions about the absorption and tissue uptake of complex polyphenols such as the proanthocyanins can be answered by labeling thesepolyphenols with (14)C-sucrose in plant cell culture and then purifying them for use in animal experiments, routinely carried out with great sensitivity, specificity and quantification by LC-tandem mass spectrometry. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2011 review

The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems

[Review of ]. Food & Function, 2(5), 235–244.

By: S. Barnes, J. Prasain, T. D'Alessandro, A. Arabshahi, N. Botting, M. Lila, G. Jackson, E. Janle, C. Weaver

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Antioxidant Capacity and in Vitro Inhibition of Adipogenesis and Inflammation by Phenolic Extracts of Vaccinium floribundum and Aristotelia chilensis

Journal of Agricultural and Food Chemistry, 58(16), 8966–8976.

By: M. Schreckinger, J. Wang, G. Yousef, M. Lila* & E. Gonzalez de Mejia

author keywords: Aristotelia chilensis; Vaccinium floribundum; adipogenesis; anthocyanins; inflammation; proanthocyanidins; obesity
MeSH headings : 3T3-L1 Cells; Adipogenesis / drug effects; Animals; Antioxidants / analysis; Cell Line; Elaeocarpaceae / chemistry; In Vitro Techniques; Inflammation / prevention & control; Mice; Phenols / chemistry; Plant Extracts / pharmacology; Polyphenols / analysis; Polyphenols / pharmacology; Vaccinium / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Antioxidant Activity and Oxidative Stress; Morinda citrifolia extract uses
TL;DR: The anthocyanins and proanthocyanidin-enriched fraction from V. floribundum and A. chilensis phytochemicals limit adipogenesis and inflammatory pathways in vitro, warranting further in vivo studies. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2010 article

Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L.

Graziose, R., Rathinasabapathy, T., Lategan, C., Poulev, A., Smith, P. J., Grace, M., … Raskin, I. (2010, September 7). Journal of Ethnopharmacology, Vol. 133, pp. 26–30.

By: R. Graziose, T. Rathinasabapathy*, C. Lategan*, A. Poulev*, P. Smith*, M. Grace n, M. Lila n, I. Raskin*

Contributors: R. Graziose, T. Rathinasabapathy, C. Lategan*, A. Poulev*, P. Smith*, M. Grace n, M. Lila n, I. Raskin*

author keywords: Antimalarial; Aporphine alkaloids; Sesquiterpene lactones; Liriodendron tulipifera L.; Magnoliaceae; Cytotoxicity
MeSH headings : Alkaloids / chemistry; Alkaloids / isolation & purification; Alkaloids / pharmacology; Antimalarials / chemistry; Antimalarials / isolation & purification; Antimalarials / pharmacology; Aporphines / chemistry; Aporphines / isolation & purification; Aporphines / pharmacology; Lactones / chemistry; Lactones / isolation & purification; Lactones / pharmacology; Liriodendron / chemistry; Malaria / drug therapy; Phytotherapy; Plant Bark; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Extracts / pharmacology; Plant Leaves; Sesquiterpenes / chemistry; Sesquiterpenes / isolation & purification; Sesquiterpenes / pharmacology; United States
topics (OpenAlex): Traditional and Medicinal Uses of Annonaceae; Phytochemical compounds biological activities; Insect Pest Control Strategies
TL;DR: This work supports the historical use of Liriodendron tulipifera as an antimalarial remedy of the United States and characterizes its antiplasmodial constituents. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2010 journal article

Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana

Natural Product Communications, 5(12), 1869–1872.

By: M. Grace, C. Lategan, F. Mbeunkui, R. Graziose, P. Smith, I. Raskin, M. Lila

Source: NC State University Libraries
Added: August 6, 2018

2010 article

Characterization of Anthocyanins and Proanthocyanidins in Wild and Domesticated Mexican Blackberries (Rubus spp.)

Cuevas-Rodríguez, E. O., Yousef, G. G., García-Saucedo, P. A., López-Medina, J., Paredes-López, O., & Lila, M. A. (2010, May 27). Journal of Agricultural and Food Chemistry, Vol. 58, pp. 7458–7464.

author keywords: Anthocyanin; proanthocyanidin; ellagitannins; Rubus; HPLC-ESI-MS
MeSH headings : Anthocyanins / analysis; Fruit / chemistry; Fruit / genetics; Genotype; Mexico; Plant Extracts / analysis; Proanthocyanidins / analysis; Rosaceae / chemistry; Rosaceae / genetics
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Botanical Research and Applications; Horticultural and Viticultural Research
TL;DR: Recommendations for dietary intake of blackberries for human health benefits need to take into account the source, because of the wide inherent variation in bioactive polyphenolic content in different blackberry genotypes. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Comparative in vitro bioactivities of tea extracts from six species of Ardisia and their effect on growth inhibition of HepG2 cells

Journal of Ethnopharmacology, 130(3), 536–544.

By: A. Newell*, G. Yousef*, M. Lila*, M. Ramírez-Mares* & E. Gonzalez de Mejia*

author keywords: Tea; Ardisia; Polyphenols; Liver cancer; HepG2; Apoptosis
MeSH headings : Antineoplastic Agents, Phytogenic / administration & dosage; Antineoplastic Agents, Phytogenic / pharmacology; Antioxidants / administration & dosage; Antioxidants / isolation & purification; Antioxidants / pharmacology; Apoptosis / drug effects; Ardisia / chemistry; Flavonoids / administration & dosage; Flavonoids / isolation & purification; Flavonoids / pharmacology; Hep G2 Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms / drug therapy; Liver Neoplasms / pathology; Medicine, Traditional; Phenols / administration & dosage; Phenols / isolation & purification; Phenols / pharmacology; Plant Extracts / administration & dosage; Plant Extracts / pharmacology; Polyphenols; Species Specificity; Tea / chemistry; Topoisomerase II Inhibitors
topics (OpenAlex): Phytochemistry and Bioactivity Studies; Bioactive Compounds and Antitumor Agents; Phytochemistry and Biological Activities
TL;DR: Although the mechanism is not entirely clear, AC, ACR, and AJ are the Ardisia species with the greatest anticancer potential against liver cancer cells in vitro and deserve further investigation. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2010 article

Inhibition of Pro-inflammatory Responses and Antioxidant Capacity of Mexican Blackberry (Rubus spp.) Extracts

Cuevas-Rodríguez, E. O., Dia, V. P., Yousef, G. G., García-Saucedo, P. A., López-Medina, J., Paredes-López, O., … Lila, M. A. (2010, August 17). Journal of Agricultural and Food Chemistry, Vol. 58, pp. 9542–9548.

author keywords: Inflammation; wild blackberries; polyphenolic-rich fractions (PAE); antioxidant capacity; anthocyanins (ANC); proanthocyanidins (PAC); Rubus
MeSH headings : Animals; Antioxidants / pharmacology; Cell Line; Inflammation Mediators / pharmacology; Mice; Plant Extracts / pharmacology; Rosaceae / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Fungal Biology and Applications; Pomegranate: compositions and health benefits
TL;DR: Wild genotypes of Mexican blackberries, as rich sources of polyphenolics that have both antioxidant and anti-inflammatory properties, showed particular promise for inclusion in plant improvement programs designed to develop new varieties with nutraceutical potential. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Screening and Selection of High Carotenoid Producing in Vitro Tomato Cell Culture Lines for [13C]-Carotenoid Production

Journal of Agricultural and Food Chemistry, 58(18), 9979–9987.

By: N. Engelmann*, J. Campbell*, R. Rogers*, S. Rupassara*, P. Garlick*, M. Lila*, J. Erdman*

author keywords: Solanum lycopersicum; Solanum pimpinellifolium; plant cell culture; lycopene; phytoene; metabolic tracing; isotopic labeling; carotenoids; tomato; nutrition; metabolism
MeSH headings : Carbon Isotopes; Carotenoids / biosynthesis; Cell Line; Isotope Labeling / methods; Solanum lycopersicum / cytology; Solanum lycopersicum / metabolism
topics (OpenAlex): Antioxidant Activity and Oxidative Stress; Algal biology and biofuel production
TL;DR: This is the first report of highly enriched 13C-carotenoid production from in vitro plant cell culture and the best producers with or without the bleaching herbicides, norflurazon and 2-(4-chlorophenyl-thio)triethylamine (CPTA). (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021

2009 article

Alaskan Wild Berry Resources and Human Health under the Cloud of Climate Change

Kellogg, J., Wang, J., Flint, C., Ribnicky, D., Kuhn, P., Mejia, E. G. D., … Lila, M. A. (2009, December 21). Journal of Agricultural and Food Chemistry, Vol. 58, pp. 3884–3900.

MeSH headings : Alaska; Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Blood Glucose / drug effects; Cell Line; Climate Change; Fruit / chemistry; Health; Humans; Male; Mice; Mice, Inbred C57BL; Obesity / drug therapy; Plant Extracts / analysis; Plant Extracts / metabolism; Plant Extracts / pharmacology; Random Allocation; Rosaceae / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities
TL;DR: Local observations provided robust insights into effects of climatic fluctuations on berry abundance and quality, and preliminary site-specific compositional and bioactivity differences were noted, suggesting the need to monitor this Alaska Native resource as climate shifts affect the region. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
13. Climate Action (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2009 journal article

Herbicide Treatments Alter Carotenoid Profiles for14C Tracer Production from Tomato (Solanum lycopersicum cv. VFNT cherry) Cell Cultures

Journal of Agricultural and Food Chemistry, 57(11), 4614–4619.

By: N. Engelmann*, R. Rogers*, M. Lila* & J. Erdman*

author keywords: Solanum lycopersicum; bleaching herbicide; radiolabeling; metabolic tracer; cell culture; lycopene; phytoene; phytofluene
MeSH headings : Carbon Radioisotopes / metabolism; Carotenoids / metabolism; Cells, Cultured; Herbicides / pharmacology; Solanum lycopersicum / drug effects; Solanum lycopersicum / metabolism
topics (OpenAlex): Antioxidant Activity and Oxidative Stress
TL;DR: Improved culture conditions efficiently provided sufficient (14)C-carotenoids for future cell culture and animal metabolic tracking studies and led to a small increase in labeling efficiency. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021

2009 journal article

Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton

Phytomedicine, 16(5), 406–415.

By: M. Grace*, D. Ribnicky*, P. Kuhn*, A. Poulev*, S. Logendra*, G. Yousef*, I. Raskin*, M. Lila*

Contributors: M. Grace*, D. Ribnicky*, P. Kuhn*, A. Poulev*, S. Logendra*, G. Yousef*, I. Raskin*, M. Lila*

author keywords: Blueberry; Vaccinium angustifolium; Anthocyanins; Malvidin; Diabetes; Hyperglycemia; Hypoglycemia; Labrasol
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Blood Glucose / drug effects; Blueberry Plants; Drug Delivery Systems; Drug Therapy, Combination; Glucosides / analysis; Glucosides / pharmacology; Glycerides; Hypoglycemic Agents / chemistry; Hypoglycemic Agents / pharmacology; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Organic Chemicals / administration & dosage; Organic Chemicals / pharmacology; Phenols / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Natural Antidiabetic Agents Studies; Bioactive natural compounds
TL;DR: It is demonstrated that anthocyanins from blueberry have the potency to alleviate symptoms of hyperglycemia in diabetic C57b1/6J mice and their bio-enhancing effect, most likely due to increasing the bioavailability of the administered preparations. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019

2009 journal article

In vitro and in vivo evaluation of the prebiotic activity of water-soluble blueberry extracts

World Journal of Microbiology and Biotechnology, 25(7), 1243–1249.

By: A. Molan*, M. Lila*, J. Mawson* & S. De*

author keywords: Blueberry extract; Prebiotic activity; Lactobacilli; Bifidobacteria
topics (OpenAlex): Microbial Metabolites in Food Biotechnology; Probiotics and Fermented Foods; Gut microbiota and health
TL;DR: The results demonstrated for the first time that addition of BBE from both cultivars to broth media containing pure cultures of Lactobacilli and Bifidobacteriumbreve resulted in a significant increase in the population size of these strains. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2009 journal article

In vitro production of radiolabeled red clover (Trifolium pratense) isoflavones

Plant Cell, Tissue and Organ Culture (PCTOC), 98(2), 147–156.

By: N. Engelmann*, A. Reppert*, G. Yousef*, R. Rogers* & M. Lila*

author keywords: Red clover; Isoflavones; Metabolic tracers; Plant cell culture; Copper chloride; Radiolabeling; Trifolium pratense
topics (OpenAlex): Phytoestrogen effects and research; Food composition and properties; Microbial Metabolites in Food Biotechnology
TL;DR: Varying levels and timing of copper chloride elicitor did not significantly affect isoflavone accumulation, and approximately 38% of the 14C-sucrose dose accumulated in the cells. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2009 journal article

In vivo metabolic tracking of 14C-radiolabelled isoflavones in kudzu (Pueraria lobata) and red clover (Trifolium pratense) extracts

British Journal of Nutrition, 102(10), 1523–1530.

By: J. Mun*, M. Grannan*, P. Lachcik*, A. Reppert*, G. Yousef*, R. Rogers*, E. Janle*, C. Weaver*, M. Lila*

author keywords: Kudzu; Red clover; Radiolabelling; Pharmacokinetics
MeSH headings : Animals; Carbon / chemistry; Carbon Radioisotopes; Cells, Cultured; Extracellular Fluid / chemistry; Isoflavones / blood; Isoflavones / chemistry; Isoflavones / metabolism; Male; Plant Roots / cytology; Pueraria / chemistry; Rats; Rats, Sprague-Dawley; Time Factors; Trifolium / chemistry
topics (OpenAlex): Phytoestrogen effects and research; Food composition and properties; GABA and Rice Research
TL;DR: Serum pharmacokinetics suggest that extracts from kudzu may undergo enterohepatic circulation, and both extracts were rapidly absorbed, distributed in various tissues, and largely eliminated in the urine and faeces. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021

2009 journal article

Method for evaluating the potential of 14C labeled plant polyphenols to cross the blood–brain barrier using accelerator mass spectrometry

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 268(7-8), 1313–1316.

By: E. Janle*, M. Lila*, M. Grannan*, L. Wood*, A. Higgins*, G. Yousef*, R. Rogers*, H. Kim*, G. Jackson*, C. Weaver*

author keywords: Blood-brain barrier; Grape polyphenols; Pharmacokinetics; Accelerator mass spectrometry; C-14 labeled plant polyphenols
topics (OpenAlex): Medicinal Plants and Neuroprotection; Cholinesterase and Neurodegenerative Diseases; Essential Oils and Antimicrobial Activity
TL;DR: Using AMS in combination with traditional methods, it is possible to study uptake by blood, distribution to ISF and determine the amount of a dose which can reach the brain and follow the pharmacokinetics in the brain. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2009 journal article

Research highlights from the Purdue-UAB Botanicals Research Center for Age Related Diseases

Pharmaceutical Biology, 47(8), 768–773.

By: C. Weaver*, S. Barnes*, J. Wyss*, H. Kim*, D. Morré*, D. Morré*, J. Simon*, M. Lila*, E. Janle*, M. Ferruzzi*

author keywords: Botanicals; isoflavones; catechins; bone resorption; cognitive function; cancer
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Natural Antidiabetic Agents Studies; Ginkgo biloba and Cashew Applications
TL;DR: The Purdue-UAB Botanicals Research Center for Age Related Disease uses multidisciplinary and innovative technologies to investigate the bioavailability of bioactive polyphenolic constituents from botanicals and their relationship to human health. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2008 journal article

In vitro production of metabolism-enhancing phytoecdysteroids from Ajuga turkestanica

Plant Cell, Tissue and Organ Culture, 93(1), 73–83.

By: D. Cheng*, G. Yousef*, M. Grace*, R. Rogers*, J. Gorelick-Feldman*, I. Raskin*, M. Lila*

Contributors: D. Cheng*, G. Yousef*, M. Grace*, R. Rogers*, J. Gorelick-Feldman*, I. Raskin*, M. Lila*

author keywords: 20-Hydroxyecdysone; cell suspension culture; cyasterone; hairy root; methyl jasmonate; mevalonic acid; turkesterone
topics (OpenAlex): Transgenic Plants and Applications; Toxin Mechanisms and Immunotoxins; Neurobiology and Insect Physiology Research
TL;DR: The results suggest that sustainable production of metabolically active phytoecdysteroid can be achieved through hairy root culture systems. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019

2008 journal article

Influence of Alternative Liquid Chromatography Techniques on the Chemical Complexity and Bioactivity of Isolated Proanthocyanidin Mixtures

Journal of Agricultural and Food Chemistry, 56(6), 1896–1906.

By: J. Alwerdt*, D. Seigler*, E. Gonzalez de Mejia*, G. Yousef* & M. Lila*

author keywords: proanthocyanidins; wild blueberry; Vaccinium angustifolium Ait.; Toyopearl HW-40; sephadex; LH-20; silica gel type G; topolsomerase II bioassay
MeSH headings : Chromatography, High Pressure Liquid; Chromatography, Liquid / methods; Enzyme Inhibitors / pharmacology; Humans; Plant Extracts / chemistry; Plant Extracts / pharmacology; Proanthocyanidins / chemistry; Proanthocyanidins / isolation & purification; Spectrometry, Mass, Electrospray Ionization; Topoisomerase II Inhibitors
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Chromatography in Natural Products; Food Quality and Safety Studies
TL;DR: A 2(3) factorial analysis revealed that the vacuum and open column strategies for separation did not yield significantly different results in terms of mass recovery, DP, or bioactivity; however, interactions with other factors such as matrix or subfraction series resulted in distinctive shifts in fraction profiles and biological activity. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2008 journal article

Isolation of Radiolabeled Isoflavones from Kudzu (Pueraria lobata) Root Cultures

Journal of Agricultural and Food Chemistry, 56(17), 7860–7865.

By: A. Reppert*, G. Yousef*, R. Rogers* & M. Lila*

author keywords: kudzu; Pueraria lobata; isoflavones; puerarin; daidzein
MeSH headings : Carbon Radioisotopes; Isoflavones / analysis; Isoflavones / isolation & purification; Isotope Labeling; Plant Roots / chemistry; Pueraria / chemistry; Tissue Culture Techniques
topics (OpenAlex): Phytoestrogen effects and research; Food Quality and Safety Studies; GABA and Rice Research
TL;DR: The isolated isoflavones isolated from kudzu root cultures were sufficiently (14)C-labeled to permit utilization for subsequent in vivo metabolic tracking studies. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2008 journal article

Neo-clerodane diterpenes from Ajuga turkestanica

Phytochemistry Letters, 1(2), 81–84.

By: M. Grace*, D. Cheng*, I. Raskin* & M. Lila*

Contributors: M. Grace*, D. Cheng*, I. Raskin* & M. Lila*

author keywords: Ajuga turkestanica; Labiatae; Neo-clerodane diterpenes; 14,15-Dihydroajugachin B; 14-Hydro-15-methoxyajugachin B
topics (OpenAlex): Natural product bioactivities and synthesis; Biological Activity of Diterpenoids and Biflavonoids; Plant biochemistry and biosynthesis
TL;DR: The ethyl acetate extract of the aerial parts of Ajuga turkestanica afforded 6 neo-clerodane diterpenes, including two novel compounds, 14, 15-dihydroajugachin B and 14-hydro-15-methoxyajugaches B and chamaepitin, which were elucidated through exhaustive NMR spectroscopic analysis and chemical transformation. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019

2008 journal article

Optimization of Lycopene Extraction from Tomato Cell Suspension Culture by Response Surface Methodology

Journal of Agricultural and Food Chemistry, 56(17), 7710–7714.

By: C. Lu*, N. Engelmann*, M. Lila* & J. Erdman*

author keywords: tomato; cell culture; lycopene; extraction; RSM
MeSH headings : Carotenoids / analysis; Carotenoids / isolation & purification; Cell Culture Techniques; Chromatography, High Pressure Liquid; Ethanol; Fruit / chemistry; Fruit / cytology; Hydroxides; Lycopene; Solanum lycopersicum / chemistry; Organophosphates; Plant Extracts / chemistry; Potassium Compounds; Statistics as Topic
topics (OpenAlex): Antioxidant Activity and Oxidative Stress; Plant tissue culture and regeneration; Transgenic Plants and Applications; Algal biology and biofuel production; Plant biochemistry and biosynthesis
TL;DR: These optimal conditions predicted by RSM were confirmed to enhance lycopene yield from standardized tomato cell cultures by more than 3-fold. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2008 journal article

Phytochemical Composition and Metabolic Performance-Enhancing Activity of Dietary Berries Traditionally Used by Native North Americans

Journal of Agricultural and Food Chemistry, 56(3), 654–660.

By: T. Burns Kraft*, M. Dey*, R. Rogers*, D. Ribnicky*, D. Gipp*, W. Cefalu*, I. Raskin*, M. Lila*

author keywords: Amelanchier alnifolia; Viburnum trilobum; Prunus virginiana; Shepherdia argentea; diabetes; inflammation; energy expenditure
MeSH headings : Aldehyde Reductase / antagonists & inhibitors; Anthocyanins / analysis; Diet; Elaeagnaceae / chemistry; Energy Metabolism / drug effects; Flavonoids / analysis; Fruit / chemistry; Humans; Indians, North American; Plant Extracts / chemistry; Prunus / chemistry; Rosaceae / chemistry; Viburnum / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; African Botany and Ecology Studies; Food Quality and Safety Studies
TL;DR: Four wild berry species integral to the traditional subsistence diet of Native American tribal communities contain a rich array of phytochemicals that have the capacity to promote health and protect against chronic diseases, such as diabetes. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2008 journal article

Phytoecdysteroids Increase Protein Synthesis in Skeletal Muscle Cells

Journal of Agricultural and Food Chemistry, 56(10), 3532–3537.

By: J. Gorelick-Feldman*, D. MacLean*, N. Ilic*, A. Poulev*, M. Lila*, D. Cheng*, I. Raskin*

author keywords: ecdysteroid; ajuga; spinach; protein synthesis; skeletal muscle; myotube; C2C12
MeSH headings : Ajuga / chemistry; Animals; Cell Line; Ecdysteroids / analysis; Ecdysteroids / pharmacology; Ecdysterone / pharmacology; Humans; Male; Mice; Muscle Cells / drug effects; Muscle Cells / metabolism; Muscle Fibers, Skeletal / drug effects; Muscle Fibers, Skeletal / metabolism; Muscle, Skeletal / drug effects; Muscle, Skeletal / metabolism; Plants / chemistry; Protein Biosynthesis / drug effects; Rats; Rats, Sprague-Dawley; Spinacia oleracea / chemistry
topics (OpenAlex): Neurobiology and Insect Physiology Research; Insect Utilization and Effects; Antioxidant Activity and Oxidative Stress
TL;DR: An in vitro cellular assay of protein synthesis was developed and found that phytoecdysteroids increased protein synthesis by up to 20% and ecdysteroid-containing plant extracts produced similar results, which suggests a PI3K-mediated mechanism. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2008 journal article

Plant extracts from central Asia showing antiinflammatory activities in gene expression assays

Phytotherapy Research, 22(7), 929–934.

By: M. Dey*, C. Ripoll*, R. Pouleva*, R. Dorn*, I. Aranovich*, D. Zaurov*, A. Kurmukov, M. Eliseyeva ...

author keywords: antiinflammatory natural product; gene expression; real-time RT-PCR
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Asia, Central; Cell Survival / drug effects; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Dose-Response Relationship, Drug; Gene Expression / drug effects; Gene Expression Profiling; Inhibitory Concentration 50; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; Macrophages / drug effects; Macrophages / metabolism; Medicine, East Asian Traditional; Mice; Nitric Oxide Synthase Type II / genetics; Nitric Oxide Synthase Type II / metabolism; Phytotherapy; Plant Extracts / pharmacology; Plants, Medicinal / chemistry; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction
topics (OpenAlex): Natural product bioactivities and synthesis; Plant biochemistry and biosynthesis; Microbial Natural Products and Biosynthesis
TL;DR: A mouse macrophage‐based quantitative, reverse transcription polymerase chain reaction (qRT‐PCR) system was optimized to screen plant extracts for antiinflammatory activities using three well known genetic markers of inflammation, and extracts identified were able to reduce inflammatory symptoms in vivo. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2007 journal article

Antiradical Capacity and Induction of Apoptosis on HeLa Cells by a Phaseolus vulgaris Extract

Plant Foods for Human Nutrition, 63(1), 35–40.

author keywords: antiradical capacity; apoptosis; HeLa cells; Phaseolus vulgaris L; phenolic compounds
MeSH headings : Apoptosis / drug effects; Biphenyl Compounds; Dose-Response Relationship, Drug; Free Radical Scavengers; HeLa Cells; Humans; Hydrazines; Phaseolus / chemistry; Picrates; Plant Extracts / analysis; Plant Extracts / pharmacology; Proanthocyanidins / analysis; Proanthocyanidins / pharmacology
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Moringa oleifera research and applications; Coconut Research and Applications
TL;DR: The results suggest that black Jamapa bean could be an important source of polyphenolic compounds with potential biological use as antioxidant and anticancer agents. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021

2007 journal article

Physiological and biochemical responses of tomato microshoots to induced salinity stress with associated ethylene accumulation

Plant Growth Regulation, 51(2), 159–169.

By: R. Shibli*, M. Kushad*, G. Yousef* & M. Lila*

author keywords: ethylene; In vitro; microshoot; salinity; tomato
topics (OpenAlex): Plant Stress Responses and Tolerance; Plant tissue culture and regeneration; Plant responses to water stress
TL;DR: The results indicate that the increase in ethylene under salinity stress is not the primary factor contributing to salinity’s deleterious effect on tomato plant growth and physiology. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2007 journal article

Phytoene, phytofluene, and lycopene from tomato powder differentially accumulate in tissues of male Fisher 344 rats

Nutrition Research, 27(12), 794–801.

By: J. Campbell*, N. Engelmann*, M. Lila* & J. Erdman*

author keywords: carotenoids; phytoene; phytofluene; lycopene; prostate cancer; rats
topics (OpenAlex): Antioxidant Activity and Oxidative Stress; Estrogen and related hormone effects; Retinoids in leukemia and cellular processes
TL;DR: Results indicate that the relative tomato carotenoid biodistribution differs in liver and androgen-sensitive tissues, suggesting that minor changes in the number of sequential double bonds in carotanoid structures alter absorption and/or metabolism of tomato carOTenoids. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2007 journal article

Satiety in rats following blueberry extract consumption induced by appetite-suppressing mechanisms unrelated to in vitro or in vivo antioxidant capacity

Food Chemistry, 107(3), 1039–1044.

By: A. Molan*, M. Lila* & J. Mawson*

author keywords: blueberry; cultivars; satiety; rats; antioxidant; FRAP
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Antioxidant Activity and Oxidative Stress; Postharvest Quality and Shelf Life Management
TL;DR: The observed results suggest that the reduction in food intake and decrease in body weight in experimental animals is not merely a consequence of antioxidant mechanisms, and BBE may provide a good satiety inducer and weight management modulator. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2006 journal article

Biosynthesis of14C-Phytoene from Tomato Cell Suspension Cultures (Lycopersicon esculentum) for Utilization in Prostate Cancer Cell Culture Studies

Journal of Agricultural and Food Chemistry, 54(3), 747–755.

By: J. Campbell*, R. Rogers*, M. Lila* & J. Erdman*

author keywords: phytoene; phytofluene; carotenoids; tomato; Lycopersicon esculentum; prostate cancer; norflurazon
MeSH headings : Adenocarcinoma / metabolism; Carbon Radioisotopes; Carotenoids / biosynthesis; Carotenoids / metabolism; Cell Line, Tumor; Cells, Cultured; Humans; Isotope Labeling / methods; Solanum lycopersicum / metabolism; Male; Prostatic Neoplasms / metabolism
topics (OpenAlex): Antioxidant Activity and Oxidative Stress; Genetically Modified Organisms Research; Nutrition, Genetics, and Disease
TL;DR: The ability to biosynthesize, radiolabel, and isolate these carotenoids from tomato cell cultures is a novel, valuable methodology for further in vitro and in vivo investigations into the roles of phytoene and phy tofluene in cancer chemoprevention. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021

2006 journal article

Catalytic Inhibition of Human DNA Topoisomerase II by Interactions of Grape Cell Culture Polyphenols

Journal of Agricultural and Food Chemistry, 54(6), 2083–2087.

By: J. Jo*, E. Gonzalez de Mejia* & M. Lila*

author keywords: chemopreventive agents; grape cell culture; isobolographic analysis; resveratrol; synergistic interactions; topoisomerase II catalytic inhibition; Vitis
MeSH headings : Catalysis; DNA Topoisomerases, Type II / metabolism; Drug Interactions; Drug Synergism; Enzyme Inhibitors / pharmacology; Flavonoids / pharmacology; Fruit / chemistry; Humans; Phenols / pharmacology; Polyphenols; Topoisomerase II Inhibitors; Vitis / chemistry
topics (OpenAlex): Sirtuins and Resveratrol in Medicine; Ginseng Biological Effects and Applications; Phytochemical compounds biological activities
TL;DR: Evaluated the potency of, and potential interactions between, individual fractions and some of the purified bioactive polyphenols that comprise these fractions on human DNA topoisomerase II catalytic activity and demonstrated potentiating interactions between the PB2 and the other polyphenolic constituents mentioned above and between myricetin and resveratrol. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2006 journal article

Chemopreventive Activity of Polyphenolics from Black Jamapa Bean (Phaseolus vulgarisL.) on HeLa and HaCaT Cells

Journal of Agricultural and Food Chemistry, 54(6), 2116–2122.

By: X. Aparicio-Fernández*, T. García-Gasca*, G. Yousef*, M. Lila*, E. González de Mejia* & G. Loarca-Pina*

author keywords: Phaseolus vulgaris; polyphenolic compounds; cytotoxicity; HeLa cells; HaCaT cells
MeSH headings : Anticarcinogenic Agents / pharmacology; Apoptosis / drug effects; Cell Adhesion / drug effects; Cell Cycle / drug effects; Cell Division / drug effects; Cell Line, Tumor; Flavonoids / pharmacology; HeLa Cells; Humans; Keratinocytes; Methanol; Phaseolus / chemistry; Phenols / pharmacology; Plant Extracts / pharmacology; Polyphenols; Precancerous Conditions; Seeds / chemistry; Skin Neoplasms
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Moringa oleifera research and applications; Tannin, Tannase and Anticancer Activities
TL;DR: The results indicated that black Jamapa beans could be a source of polyphenolic compounds, which have an inhibitory effect toward HeLa cancer cells but are less aggressive on HaCaT premalignant cells. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021

2006 journal article

Comparative phytochemical characterization of three Rhodiola species

Phytochemistry, 67(21), 2380–2391.

By: G. Yousef*, M. Grace*, D. Cheng*, I. Belolipov*, I. Raskin* & M. Lila*

Contributors: G. Yousef*, M. Grace*, D. Cheng*, I. Belolipov*, I. Raskin* & M. Lila*

author keywords: Rhodiola heterodonta; Rhodiola semenovii; Rhodiola rosea; Crassulaceae; heterodontoside; phenylethanoid glycosides; cyanogenic glucosides; proanthocyanidins; prodelphinidins; EGCG; EGC; HPLC-ESI-MS
MeSH headings : Glucosides / chemistry; Glycosides / chemistry; Molecular Structure; Phenols / chemistry; Proanthocyanidins / chemistry; Rhodiola / chemistry; Rhodiola / classification; Rhodiola / metabolism; Species Specificity
topics (OpenAlex): Medicinal Plants and Bioactive Compounds; Pharmacological Effects of Natural Compounds; Phytochemistry and Biological Activities
TL;DR: This study resulted in the identification and isolation of phytochemical constituents for direct cross-comparison between three Rhodiola species of medicinal and pharmacological value. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019

2006 journal article

Cytotoxicity of bioactive polymeric fractions from grape cell culture on human hepatocellular carcinoma, murine leukemia and non-cancerous PK15 kidney cells

Food and Chemical Toxicology, 44(10), 1758–1767.

By: J. Jo*, E. de Mejia* & M. Lila*

author keywords: human hepatocellular carcinoma cells; mouse leukemia cells; grape cell culture; proanthocyanidin oligomers
MeSH headings : Animals; Carcinoma, Hepatocellular / drug therapy; Cell Line; Cell Line, Tumor; Flavonoids / pharmacology; Humans; Kidney / drug effects; Leukemia L1210 / drug therapy; Liver Neoplasms / drug therapy; Mice; Plant Extracts / pharmacology; Vitis / chemistry; Vitis / cytology
topics (OpenAlex): Plant Gene Expression Analysis; Sirtuins and Resveratrol in Medicine
TL;DR: Because TP-6 and its subfractions were selectively cytotoxic to cancerous cell lines tested, they warrant further investigation as potential natural anticancer agents. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2006 journal article

Identification of isoflavone glycosides inPueraria lobata cultures by tandem mass spectrometry

Phytochemical Analysis, 18(1), 50–59.

By: J. Prasain*, A. Reppert*, K. Jones*, D. Moore II*, S. Barnes* & M. Lila*

author keywords: HPLC-UV-MS; metabolic profiling; isoflavone profiling; puerarin; in vitro cultures; Pueraria lobata
MeSH headings : Cells, Cultured; Chromatography, High Pressure Liquid; Glycosides / analysis; Isoflavones / analysis; Mass Spectrometry; Plant Roots / chemistry; Pueraria / chemistry; Spectrophotometry, Ultraviolet
topics (OpenAlex): Phytoestrogen effects and research; GABA and Rice Research; Food Quality and Safety Studies
TL;DR: The molecular weights, interpretation of characteristic fragment ions obtained from HPLC-MS/MS and comparison with reported data allowed the putative identification of the isoflavone metabolites. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021

2006 journal article

The nature-versus-nurture debate on bioactive phytochemicals: the genome versus terroir

Journal of the Science of Food and Agriculture, 86(15), 2510–2515.

By: M. Ann Lila*

topics (OpenAlex): Plant biochemistry and biosynthesis; Plant tissue culture and regeneration; Plant Gene Expression Analysis
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 12, 2021

2006 journal article

ent-Beyerane diterpenoids from the heartwood of Excoecaria parvifolia

Phytochemistry, 68(4), 546–553.

By: M. Grace*, J. Faraldos*, M. Lila* & R. Coates*

Contributors: M. Grace*, J. Faraldos*, M. Lila* & R. Coates*

MeSH headings : Diterpenes / chemistry; Diterpenes / isolation & purification; Euphorbiaceae / chemistry; Models, Molecular; Molecular Structure; Plant Oils / chemistry; Wood
topics (OpenAlex): Bioactive Natural Diterpenoids Research; Plant biochemistry and biosynthesis; Biological Activity of Diterpenoids and Biflavonoids
TL;DR: Diosphenol 2 and nor-lactone 5 exhibited significant potency in bioassays for cytotoxic activity against leukemia cells (L1210). (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 12, 2019

2005 journal article

Characterization of Polyphenolics in the Seed Coat of Black Jamapa Bean (Phaseolus vulgarisL.)

Journal of Agricultural and Food Chemistry, 53(11), 4615–4622.

By: X. Aparicio-Fernandez*, G. Yousef*, G. Loarca-Pina*, E. de Mejia* & M. Lila*

MeSH headings : Anthocyanins / analysis; Chemical Fractionation; Chromatography, High Pressure Liquid; Flavonoids / analysis; Flavonoids / isolation & purification; Mass Spectrometry; Methanol; Phaseolus / chemistry; Phenols / analysis; Phenols / isolation & purification; Plant Extracts / chemistry; Polyphenols; Proanthocyanidins / analysis; Seeds / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Seed and Plant Biochemistry; Food composition and properties
TL;DR: This is the first time that myricetin glycoside and proanthocyanidin oligomers containing (epi)-gallocatechin have been reported in the black bean, and a better separation of phytochemicals was achieved using direct silica gel fractionation. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021

2005 journal article

Differential effects of blueberry proanthocyanidins on androgen sensitive and insensitive human prostate cancer cell lines

Cancer Letters, 231(2), 240–246.

By: B. Schmidt*, J. Erdman* & M. Lila*

author keywords: vaccinium; blueberry; prostate cancer; antiproliferation; proanthocyanidin
MeSH headings : Androgens / metabolism; Blueberry Plants / chemistry; Cell Proliferation / drug effects; Humans; Magnetic Resonance Spectroscopy; Male; Neoplasms, Hormone-Dependent / drug therapy; Proanthocyanidins / therapeutic use; Prostatic Neoplasms / drug therapy; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Antioxidant Activity and Oxidative Stress; Plant biochemistry and biosynthesis
TL;DR: Differences in cell growth inhibition of LNCaP and DU145 cell lines by blueberry fractions rich in proanthocyanidins indicate that blueberry proantho-phenolic compounds have an effect primarily on androgen-dependant growth of prostate cancer cells. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2005 journal article

Effects of Grape Cell Culture Extracts on Human Topoisomerase II Catalytic Activity and Characterization of Active Fractions

Journal of Agricultural and Food Chemistry, 53(7), 2489–2498.

By: J. Jo*, E. Gonzalez de Mejia* & M. Lila*

author keywords: human topoisomerase II; catalytic inhibitor; antitopoisomerase II activity; Vitis; grape cell culture; chemopreventive agents
MeSH headings : Anticarcinogenic Agents; Cells, Cultured; Chemical Fractionation; Chromatography, High Pressure Liquid; Culture Media, Conditioned; DNA Topoisomerases, Type II / metabolism; Enzyme Inhibitors / isolation & purification; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Flavonoids / isolation & purification; Flavonoids / metabolism; Flavonoids / pharmacology; Glucosides / analysis; Humans; Phenols / isolation & purification; Phenols / metabolism; Phenols / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology; Polyphenols; Proanthocyanidins / analysis; Spectrometry, Mass, Electrospray Ionization; Vitis / metabolism
topics (OpenAlex): Cancer therapeutics and mechanisms; Plant tissue culture and regeneration; Phytochemical compounds biological activities
TL;DR: The significant potency especially of TP-4 and TP-6 from grape cell cultures suggests that these fractions may have potential as chemopreventive agents. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2005 journal article

Screening Growth and Root Formation in Cadmium-Treated Turfgrass Using a Whole-Plant Microculture System

Journal of Plant Nutrition, 28(6), 1041–1048.

By: Y. Kuo*, Y. Chang*, M. Lila* & H. Chiu*

author keywords: bermudagrass; seashore paspalum; whole-plant microculture; phytoremediation
topics (OpenAlex): Plant tissue culture and regeneration; Turfgrass Adaptation and Management
TL;DR: Microculture at the whole-plant level in vitro enables intact root growth observations through the culture medium and vessel, and offers a potential pre-screening method for putative heavy-metal-tolerant turfgrasses before commercialization and use in phytoremediation to clean up contaminated soils. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2004 journal article

An enclosed-chamber labeling system for the safe 14C-enrichment of phytochemicals in plant cell suspension cultures

In Vitro Cellular & Developmental Biology - Plant, 40(1), 80–85.

By: M. Crusak*, R. Rogers*, G. Yousef*, J. Erdman* & M. Lila*

author keywords: flavonoids; radiolabel; Vaccinium pahalae; ohelo berry; Vitis vinifera; grape
topics (OpenAlex): Plant tissue culture and regeneration; Plant nutrient uptake and metabolism; Plant Gene Expression Analysis
TL;DR: An enclosed-chamber labeling system in which cell suspension cultures can be safely and efficiently grown when supplied with 14C-enriched precursors and showed that flavonoids were produced with either sucrose or glucose as the carbohydrate source, although flavonoid productivity was higher with sucrose. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020

2004 journal article

Biosynthesis and Characterization of14C-Enriched Flavonoid Fractions from Plant Cell Suspension Cultures

Journal of Agricultural and Food Chemistry, 52(5), 1138–1145.

By: G. Yousef*, D. Seigler*, M. Grusak*, R. Rogers*, C. Knight*, T. Kraft*, J. Erdman*, M. Lila*

author keywords: radiolabeling; proanthocyanidins; anthocyanins; flavonoid-rich fractions; ohelo (Vaccinium); grape (Vitis)
MeSH headings : Anthocyanins / analysis; Anthocyanins / biosynthesis; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Flavonoids / analysis; Flavonoids / biosynthesis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Vaccinium / metabolism; Vitis / metabolism
topics (OpenAlex): Plant tissue culture and regeneration; Fungal Biology and Applications; Plant Gene Expression Analysis
TL;DR: A range of radiolabeled anthocyanins, proanthocyanidins, and other flavonoids were accumulated by cell suspension cultures of two plant species, ohelo and grape, after providing uniformly labeled sucrose to the medium to gauge their bioavailability and accumulation in target organs. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021

2004 journal article

Effective Separation of Potent Antiproliferation and Antiadhesion Components from Wild Blueberry (Vaccinium angustifoliumAit.) Fruits

Journal of Agricultural and Food Chemistry, 52(21), 6433–6442.

By: B. Schmidt*, A. Howell*, B. McEniry*, C. Knight*, D. Seigler*, J. Erdman,*, M. Lila*

author keywords: Vaccinium angustifolium Ait.; blueberry; antiproliferation; antiadhesion; proanthocyanidin; condensed tannins
MeSH headings : Animals; Bacterial Adhesion / drug effects; Cell Division / drug effects; Escherichia coli; Humans; Liver Neoplasms, Experimental / pathology; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Polymers / chemistry; Proanthocyanidins / chemistry; Proanthocyanidins / isolation & purification; Proanthocyanidins / pharmacology; Prostatic Neoplasms / pathology; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Tumor Cells, Cultured; Vaccinium / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Natural Antidiabetic Agents Studies; Ginkgo biloba and Cashew Applications
Sources: Crossref, NC State University Libraries
Added: January 24, 2021

Employment

Updated: September 8th, 2025 14:37

2008 - 2026

NCSU Kannapolis, NC, US
DHM Distinguished Professor FBNS

Education

Updated: March 28th, 2017 21:23

1980 - 1984

University of Wisconsin Madison Madison, WI, US
PhD Hort/Botany

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