Mengrui Liu

Works (4)

Updated: April 25th, 2025 17:57

2025 article

Inhalable Hsa‐miR‐30a‐3p Liposomes Attenuate Pulmonary Fibrosis

Liu, S., Popowski, K. D., Eckhardt, C. M., Zhang, W., Li, J., Jing, Y., … Cheng, K. (2025, March 22). Advanced Science.

By: S. Liu *, K. Popowski n , C. Eckhardt *, W. Zhang *, J. Li*, Y. Jing, D. Silkstone n, E. Belcher  n ...

author keywords: CNPY2; idiopathic pulmonary fibrosis; inhalation; miR-30a-3p
topics (OpenAlex): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis; Medical Imaging and Pathology Studies; Extracellular vesicles in disease
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Source: Web Of Science
Added: March 31, 2025

2024 article

Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity

Liu, M., Hu, S., Yan, N., Popowski, K. D., & Cheng, K. (2024, January 11). Nature Nanotechnology, Vol. 1.

By: M. Liu*, S. Hu* , N. Yan *, K. Popowski n  & K. Cheng*

MeSH headings : Humans; Interleukin-12 / genetics; Lung Neoplasms / genetics; Lung Neoplasms / therapy; RNA, Messenger / genetics; Interferon-gamma / genetics; Cytokines; Extracellular Vesicles; Tumor Microenvironment
topics (OpenAlex): Extracellular vesicles in disease; Inhalation and Respiratory Drug Delivery; Nanoplatforms for cancer theranostics
TL;DR: The delivery of IL-12 mRNA encapsulated in extracellular vesicles to lungs via inhalation is reported on and the immunotherapeutic potential of targeted cytokine mRNA therapy is demonstrated, showing the potential for locally delivered cytokine-based immunotherapies to address orthotopic and metastatic lung tumours. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 29, 2024

2022 article

Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

Wang, Z., Popowski, K. D., Zhu, D., Juan Abad, B. L., Wang, X., Liu, M., … Cheng, K. (2022, July 4). Nature Biomedical Engineering, Vol. 7.

By: Z. Wang n, K. Popowski n , D. Zhu n , B. Juan Abad n, X. Wang  n, M. Liu n, H. Lutz  n, N. Naeyer* ...

MeSH headings : Animals; Antibodies, Neutralizing; CD8-Positive T-Lymphocytes; COVID-19 / prevention & control; COVID-19 Vaccines; Exosomes; Humans; Mice; Mice, Inbred BALB C; SARS-CoV-2; Viral Vaccines
topics (OpenAlex): SARS-CoV-2 and COVID-19 Research; Extracellular vesicles in disease; Inhalation and Respiratory Drug Delivery
TL;DR: The design and preclinical testing of an inhalable virus-like-particle as a COVID-19 vaccine that, after lyophilisation, is stable at room temperature for over three months and elicits systemic and mucosal immune responses in small animals is reported. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 11, 2022

2021 article

Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies

Liu, M., Juan Abad, B. L., & Cheng, K. (2021, April 5). Advanced Drug Delivery Reviews.

By: M. Liu n, B. Juan Abad n & K. Cheng n

author keywords: Cardiac fibrosis; Cardiac fibroblast; Myofibroblasts; Myocardial remodeling; Reprogramming; Drug delivery systems
MeSH headings : Animals; Drug Delivery Systems; Extracellular Matrix / metabolism; Extracellular Matrix / pathology; Fibrosis / metabolism; Fibrosis / pathology; Humans; Myocardium / metabolism; Myocardium / pathology; Myofibroblasts / metabolism; Myofibroblasts / pathology; Pharmaceutical Preparations / chemistry
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Cardiac Fibrosis and Remodeling; Cardiac Structural Anomalies and Repair
TL;DR: This review will outline the progress of cardiac fibrosis and its contributions to the heart failure, and shed light on the role of myoFbs in the regulation of adverse remodeling. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 28, 2021

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