Megan L Koehler

Works (1)

Updated: July 5th, 2023 15:47

2010 journal article

Evaluating Haplotype Effects in Case-Control Studies via Penalized-Likelihood Approaches: Prospective or Retrospective Analysis?

GENETIC EPIDEMIOLOGY, 34(8), 892–911.

By: M. Koehler n, H. Bondell n & J. Tzeng n 

author keywords: haplotype-based association analysis; variable selection; regularized regression; prospective likelihood; retrospective likelihood
MeSH headings : Algorithms; Case-Control Studies; Computer Simulation; Genes, Dominant; Genes, Recessive; Genotype; Haplotypes / genetics; Humans; Likelihood Functions; Models, Genetic; Prospective Studies; Regression Analysis; Retrospective Studies
TL;DR: The results suggest that the impact of prospective analyses depends on (1) the underlying genetic mode and (2) the genetic model adopted in the analysis, and when the correct genetic model is used, the difference between the two analyses is negligible for additive and slight for dominant haplotype effects. (via Semantic Scholar)
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Added: August 6, 2018

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