Works (7)
Updated: July 5th, 2023 15:42
2016 review
Current and future prospects for CRISPR-based tools in bacteria
[Review of ]. BIOTECHNOLOGY AND BIOENGINEERING, 113(5), 930–943.
author keywords: antimicrobials; Cas9; genetic control; genetic circuits; genome engineering; undomesticated microbes
MeSH headings : Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacteria / genetics; Bacterial Infections / drug therapy; CRISPR-Cas Systems; Clustered Regularly Interspaced Short Palindromic Repeats; Drug Discovery; Drug Resistance, Bacterial; Gene Editing / methods; Gene Expression Regulation, Bacterial; Genetic Engineering / methods; Genome, Bacterial; Humans
TL;DR:
Overall, CRISPR‐Cas systems have formed the basis of an ever‐expanding genetic toolbox and hold tremendous potential for the future understanding and engineering of the bacterial world.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Engineering genes with CRISPR-Cas9
Chemical Engineering Progress , 112(9), 36–41.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
The CRISPR RNA-guided surveillance complex in Escherichia coli accommodates extended RNA spacers
NUCLEIC ACIDS RESEARCH, 44(15), 7385–7394.
MeSH headings : CRISPR-Associated Proteins / metabolism; CRISPR-Cas Systems / genetics; DNA / metabolism; Escherichia coli / genetics; Escherichia coli Proteins / metabolism; Gene Expression Regulation, Bacterial; Gene Silencing; Macromolecular Substances / chemistry; Macromolecular Substances / metabolism; RNA, Bacterial / chemistry; RNA, Bacterial / genetics; RNA, Guide, Kinetoplastida / chemistry; RNA, Guide, Kinetoplastida / genetics; Transcription, Genetic
TL;DR:
It is found that extending the spacer portion of the crRNA resulted in larger Cascade complexes with altered stoichiometry and preserved in vitro binding affinity for target DNA, and spacer length can be modified to fine-tune Cascade activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Impact of Residual Inducer on Titratable Expression Systems
PLOS ONE, 10(9).
MeSH headings : Arabinose / biosynthesis; Arabinose / genetics; Bacterial Proteins / biosynthesis; Bacterial Proteins / genetics; Escherichia coli; Flow Cytometry; Gene Expression Regulation, Bacterial; Models, Theoretical; Plasmids; Promoter Regions, Genetic; Riboswitch / genetics; Thiamine / genetics; Thiamine Pyrophosphate / biosynthesis; Thiamine Pyrophosphate / genetics
TL;DR:
It is found that residual inducer had a distinct effect on “all-or-none” systems, which exhibited increased sensitivity to the added inducer until becoming fully induced.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression
NUCLEIC ACIDS RESEARCH, 43(1), 674–681.
MeSH headings : CRISPR-Associated Proteins / genetics; CRISPR-Cas Systems; Cell Engineering; Escherichia coli / genetics; Gene Deletion; Transcription, Genetic
TL;DR:
It is found that deletion of the signature cas3 gene converted this immune system in Escherichia coli into a programmable gene regulator capable of reversible gene silencing of heterologous and endogenous genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Programmable Removal of Bacterial Strains by Use of Genome-Targeting CRISPR-Cas Systems
MBIO, 5(1).
MeSH headings : CRISPR-Cas Systems; DNA, Bacterial / genetics; DNA, Bacterial / metabolism; Escherichia coli / genetics; Genome, Bacterial; Hydrolysis; Microbial Viability
TL;DR:
It is demonstrated that genome targeting with CRISPR-Cas systems can be employed for the sequence-specific and titratable removal of individual bacterial strains and species and may open new avenues for the development of “smart” antibiotics that circumvent multidrug resistance and differentiate between pathogenic and beneficial microorganisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Embedded collagen deformation models for computational modeling of healthy, keratoconic, and crosslinked corneas
Journal of Mechanics in Medicine and Biology, 13(3).
Source: NC State University Libraries
Added: August 6, 2018
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