Mary Williard Elting

mitotic spindle, mammalian mitosis, fission yeast mitosis, cellular biophysics, laser ablation of live cells, live cell confocal imaging, cell biology, biophysics, microtubules, cytoskeleton

Works (34)

Updated: March 9th, 2026 07:16

2026 article

Spindle biochemistry responds to compressive force from the nuclear envelope to tune spindle dynamics during closed mitosis

Mahoney, T., Needham, C., Hakeem, R., Begley, M., Medina, C. P., & Elting, M. W. (2026, January 15). (Vol. 1). Vol. 1.

By: T. Mahoney n, C. Needham n, R. Hakeem n, M. Begley n, C. Medina n & M. Elting n 

topics (OpenAlex): Microtubule and mitosis dynamics; Nuclear Structure and Function; Cardiomyopathy and Myosin Studies
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: January 18, 2026

2025 article

BPS2025 - Probing nuclear mechanics across cell division through protein diffusion

Goodbee, N. Z., Elting, M. W., & LeBlanc, S. J. (2025, February 1). Biophysical Journal, Vol. 2.

By: N. Goodbee n, M. Elting n  & S. LeBlanc n 

topics (OpenAlex): Nuclear Structure and Function; Mitochondrial Function and Pathology
Sources: NC State University Libraries, NC State University Libraries
Added: March 4, 2026

2025 article

Cellularization in chytrid fungi uses distinct mechanisms from conventional cytokinesis and cellularization in animals and yeast

Medina, E. M., Elting, M. W., & Fritz-Laylin, L. (2025, December 15). Current Biology, Vol. 12.

By: E. Medina *, M. Elting n  & L. Fritz-Laylin *

MeSH headings : Cytokinesis / physiology; Animals; Chytridiomycota / physiology; Chytridiomycota / cytology; Cell Nucleus / physiology; Cell Nucleus / metabolism; Cell Membrane / metabolism; Microtubules / metabolism; Centrosome
topics (OpenAlex): Genetic and Kidney Cyst Diseases; Fungal and yeast genetics research; Microtubule and mitosis dynamics
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: January 13, 2026

2025 article

Mechanical Coupling With the Nuclear Envelope Shapes the Schizosaccharomyces pombe Mitotic Spindle

Begley, M. A., Mahoney, T., Medina, C. P., Zareiesfandabadi, P., Rapp, M. B., Tirfe, M., … Elting, M. W. (2025, May 10). Cytoskeleton, Vol. 5.

By: M. Begley n, T. Mahoney n, C. Medina  n, P. Zareiesfandabadi n, M. Rapp n, M. Tirfe n, S. LeBlanc n , M. Betterton *, M. Elting n 

author keywords: closed mitosis; cytoskeleton; fission yeast; mitotic spindle; nuclear mechanics
topics (OpenAlex): Microtubule and mitosis dynamics; Nuclear Structure and Function; Photosynthetic Processes and Mechanisms
Sources: Web Of Science, NC State University Libraries
Added: May 19, 2025

2024 article

Extended time, elevated expectations: The unappreciated downsides of pausing the tenure clock

Holland, M. A., Maisel, K., Ibberson, C. B., Wiley, L. K., Burnett, D. C., Mace, E. M., & Elting, M. W. (2024, August 16). Proceedings of the National Academy of Sciences, Vol. 121.

By: M. Holland *, K. Maisel *, C. Ibberson *, L. Wiley *, D. Burnett *, E. Mace *, M. Elting n 

topics (OpenAlex): Workplace Violence and Bullying; Management and Organizational Studies; Healthcare Quality and Management
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5. Gender Equality (Web of Science)
10. Reduced Inequalities (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 24, 2025

2023 article

A unified model for the dynamics of ATP-independent ultrafast contraction

Floyd, C., Molines, A. T., Lei, X., Honts, J. E., Chang, F., Elting, M. W., … Bhamla, M. S. (2023, June 12). Proceedings of the National Academy of Sciences, Vol. 120.

By: C. Floyd *, A. Molines *, X. Lei*, J. Honts*, F. Chang *, M. Elting n , S. Vaikuntanathan *, A. Dinner *, M. Bhamla *

author keywords: ultrafast motion; calcium-powered dynamics; protist physiology; mechanochemical modeling; synthetic biology
MeSH headings : Actin Cytoskeleton; Actomyosin; Artificial Cells; Biomedical Engineering; Adenosine Triphosphate
topics (OpenAlex): Nanopore and Nanochannel Transport Studies; Advanced Thermodynamics and Statistical Mechanics; Hemoglobin structure and function
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 14, 2023

2023 article

Mitosis: Augmin-based bridges keep kinetochores in line

Begley, M. A., & Elting, M. W. (2023, February 1). Current Biology, Vol. 33, pp. R118–R121.

By: M. Begley n & M. Elting n 

MeSH headings : Kinetochores; Microtubules / genetics; Mitosis; Spindle Apparatus / genetics; Chromosome Segregation
topics (OpenAlex): Microtubule and mitosis dynamics; Cellular transport and secretion; DNA and Nucleic Acid Chemistry
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 24, 2023

2022 article

A unified model for the dynamics of ATP-independent ultrafast contraction

Floyd, C., Molines, A. T., Lei, X., Honts, J. E., Chang, F., Elting, M. W., … Bhamla, M. S. (2022, October 16). [], Vol. 10.

By: C. Floyd *, A. Molines *, X. Lei*, J. Honts*, F. Chang *, M. Elting n , S. Vaikuntanathan *, A. Dinner *, M. Bhamla *

topics (OpenAlex): Micro and Nano Robotics; Photoreceptor and optogenetics research; Protist diversity and phylogeny
TL;DR: This study image and quantitatively analyze the contractile kinematics observed in two ciliated protists and proposes a minimal mathematical model that reproduces the observations as well as those published previously, and reveals three distinct dynamic regimes. (via Semantic Scholar)
Source: ORCID
Added: February 22, 2024

2022 article

Laser ablation reveals the impact of Cdc15p on the stiffness of the contractile ring

Moshtohry, M., Bellingham-Johnstun, K., Elting, M. W., & Laplante, C. (2022, March 11). Molecular Biology of the Cell, Vol. 33.

By: M. Moshtohry n, K. Bellingham-Johnstun n, M. Elting n  & C. Laplante n

MeSH headings : Actin Cytoskeleton / metabolism; Cytokinesis; Laser Therapy; Schizosaccharomyces / metabolism; Schizosaccharomyces pombe Proteins / metabolism
topics (OpenAlex): Cellular Mechanics and Interactions; Diamond and Carbon-based Materials Research; Force Microscopy Techniques and Applications
TL;DR: This work shows that the severed constricting contractile ring recoils to a finite point leaving a gap that can heal if less than ∼1 µm, and proposes that Cdc15p impacts the stiffness of the contractiles ring more than the viscous drag. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: June 6, 2022

2022 article

Mechanical coupling with the nuclear envelope shapes the S. pombe mitotic spindle

Begley, M. A., Medina, C. P., Couture, T., Zareiesfandabadi, P., Rapp, M. B., Tirfe, M., … Elting, M. W. (2022, December 29). [], Vol. 12.

By: M. Begley n, C. Medina  n, T. Couture, P. Zareiesfandabadi  n, M. Rapp n, M. Tirfe, S. LeBlanc, M. Betterton, M. Elting n 

topics (OpenAlex): Microtubule and mitosis dynamics; Fungal and yeast genetics research; Plant Reproductive Biology
TL;DR: A quantitative model is used to interpret how the behaviors of spindles and nuclei in live mitotic fission yeast following laser ablation directly demonstrate that fission yeast spindles and nuclear envelopes are a mechanical pair that can each shape the other’s morphology. (via Semantic Scholar)
Source: ORCID
Added: February 22, 2024

2021 article

Automated tracking of S. pombe spindle elongation dynamics

Uzsoy, A. S. M., Zareiesfandabadi, P., Jennings, J., Kemper, A. F., & Elting, M. W. (2021, June 21). Journal of Microscopy, Vol. 6.

By: A. Uzsoy  n, P. Zareiesfandabadi n, J. Jennings n , A. Kemper n  & M. Elting n 

author keywords: automation; cell division; fission yeast; fluorescence imaging; image analysis; live-cell imaging; mitotic spindle
MeSH headings : Microscopy; Microtubules / chemistry; Mitosis; Schizosaccharomyces; Spindle Apparatus
topics (OpenAlex): Cell Image Analysis Techniques; Advanced Fluorescence Microscopy Techniques; Microtubule and mitosis dynamics
TL;DR: An ImageJ plugin is developed that can automatically track S. pombe spindle length over time and replace manual or semi-automated tracking of spindle elongation dynamics, which will allow automatic analysis of large microscopy data sets and facilitate screening for effects of cell biological perturbations on mitotic progression. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 7, 2021

2021 article

Cytoskeletal biophysics: Passive crosslinker adapts to keep microtubule bundles on track

Elting, M. W. (2021, June 1). Current Biology, Vol. 31, pp. R793–R796.

By: M. Elting n 

MeSH headings : Biophysics; Microtubules; Spindle Apparatus
topics (OpenAlex): Microtubule and mitosis dynamics; Cellular Mechanics and Interactions; Nuclear Structure and Function
TL;DR: This new study demonstrates in vitro how the mitotic crosslinker PRC1 can tune its behavior to regulate the speed of microtubule sliding. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 6, 2021

2021 article

Force by minus-end motors Dhc1 and Klp2 collapses the S. pombe spindle after laser ablation

Zareiesfandabadi, P., & Elting, M. W. (2021, December 21). Biophysical Journal, Vol. 121, pp. 263–276.

By: P. Zareiesfandabadi n & M. Elting n 

Contributors: M. Elting n 

MeSH headings : Dyneins / metabolism; Kinesins / genetics; Laser Therapy; Microtubule-Associated Proteins / metabolism; Microtubules / metabolism; Mitosis; Schizosaccharomyces / genetics; Schizosaccharomyces pombe Proteins / metabolism; Spindle Apparatus / metabolism
topics (OpenAlex): Microtubule and mitosis dynamics; Cellular Mechanics and Interactions; Advanced Electron Microscopy Techniques and Applications
TL;DR: This work finds that previously hypothesized viscoelastic relaxation of the nucleus cannot explain spindle shortening in response to laser ablation and finds that spindle pole bodies collapse toward each other after ablation, but spindle geometry is often rescued, allowing spindles to resume elongation. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 7, 2022

2021 article

K-fiber bundles in the mitotic spindle are mechanically reinforced by Kif15

Begley, M. A., Solon, A. L., Davis, E. M., Sherrill, M. G., Ohi, R., & Elting, M. W. (2021, October 20). (C. Walczak, Ed.). Molecular Biology of the Cell, Vol. 32.

By: M. Begley n, A. Solon*, E. Davis n, M. Sherrill n, R. Ohi* & M. Elting n 

Contributors: M. Elting n 

Ed(s): C. Walczak

MeSH headings : Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Cell Line; Humans; Kidney / cytology; Kinesins / antagonists & inhibitors; Kinesins / genetics; Kinesins / metabolism; Kinetochores; Microtubules / metabolism; Spindle Apparatus / physiology; Time-Lapse Imaging
topics (OpenAlex): Microtubule and mitosis dynamics; Cellular Mechanics and Interactions; Cellular transport and secretion; Nuclear Structure and Function
TL;DR: The data suggest that forces holding k-fibers together are of similar magnitude to other spindle forces, and that Kif15, acting as a microtubule crosslinker, helps fortify and repair k-Fibers. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 21, 2022

2021 journal article

Viscoelastic Relaxation of the Nuclear Envelope Does Not Cause the Collapse of the Spindle After Ablation in S. pombe

Journal of Undergraduate Research in Physics. https://spsnational.org/file/397396/download?token=AYSdz03A#page=60

By: P. Zareiesfandabadi & M. Elting 

spsnational.org
Source: ORCID
Added: February 22, 2024

2020 article

K-fiber bundles in the mitotic spindle are mechanically reinforced by Kif15

Begley, M. A., Solon, A. L., Davis, E. M., Sherrill, M. G., Ohi, R., & Elting, M. W. (2020, May 20). [], Vol. 5.

By: M. Begley n, A. Solon *, E. Davis  n, M. Sherrill n, R. Ohi * & M. Elting n 

topics (OpenAlex): Microtubule and mitosis dynamics; Genomics and Chromatin Dynamics; Cellular Mechanics and Interactions
Source: ORCID
Added: February 22, 2024

2020 journal article

Knitting Ripples

Patterns, 1(2), 100034.

By: K. Daniels n  & M. Elting n 

Contributors: K. Daniels n  & M. Elting n 

topics (OpenAlex): Advanced Materials and Mechanics; Textile materials and evaluations; Interactive and Immersive Displays
TL;DR: Two knitting patterns for scarves are presented to illustrate how ripples can arise through adding stitches to the material as it is created. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: May 16, 2020

2020 article

The collapse of the spindle following ablation in S. pombe is mediated by microtubules and the motor protein dynein

Zareiesfandabadi, P., & Elting, M. W. (2020, October 21). [], Vol. 10.

By: P. Zareiesfandabadi  n & M. Elting n 

topics (OpenAlex): Microtubule and mitosis dynamics; Fungal and yeast genetics research; Plant nutrient uptake and metabolism
TL;DR: It is found that previously hypothesized viscoelastic relaxation of the nucleus cannot fully explain spindle shortening in response to laser ablation, and a role for dynein is suggested in redundantly supporting force balance and bipolarity in the S. pombe spindle. (via Semantic Scholar)
Source: ORCID
Added: February 22, 2024

2018 journal article

The Spindle: Integrating Architecture and Mechanics across Scales

Trends in Cell Biology, 28(11), 896–910.

By: M. Elting n , P. Suresh * & S. Dumont *

Contributors: M. Elting n , P. Suresh * & S. Dumont *

MeSH headings : Animals; Chromosomes / metabolism; Humans; Mitosis; Spindle Apparatus / chemistry; Spindle Apparatus / metabolism
topics (OpenAlex): Microtubule and mitosis dynamics; Cellular Mechanics and Interactions; Protist diversity and phylogeny
TL;DR: The molecular force generators of the spindle are introduced, and it is discussed how they organize microtubules into diverse architectural modules and give rise to the emergent mechanics of the mammalian spindle. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020

2017 article

Local Load-Bearing by Kinetochore-Fibers in the Mammalian Spindle Provides Mechanical Isolation and Redundancy

Elting, M. W., Udy, D. B., Prakash, M., & Dumont, S. (2017, February 1). Biophysical Journal, Vol. 112, p. 432a.

By: M. Elting* , D. Udy, M. Prakash & S. Dumont

topics (OpenAlex): Microtubule and mitosis dynamics; Cellular Mechanics and Interactions; Plant Molecular Biology Research
TL;DR: The data indicate that the architecture of the dynamic mammalian spindle provides k-fibers with mechanical isolation and load-bearing redundancy well-suited for robust chromosome segregation. (via Semantic Scholar)
Source: ORCID
Added: February 22, 2024

2017 journal article

Mapping Load-Bearing in the Mammalian Spindle Reveals Local Kinetochore Fiber Anchorage that Provides Mechanical Isolation and Redundancy

Current Biology, 27(14), 2112–2122.e5.

By: M. Elting* , M. Prakash *, D. Udy * & S. Dumont *

Contributors: M. Elting* , M. Prakash *, D. Udy * & S. Dumont *

MeSH headings : Animals; Cell Line; Kinetics; Kinetochores / physiology; Potoroidae; Spindle Apparatus / physiology
topics (OpenAlex): Microtubule and mitosis dynamics; Cellular Mechanics and Interactions; RNA Research and Splicing
TL;DR: The data and model suggest that NuMA-mediated crosslinks locally bear load, providing mechanical isolation and redundancy while allowing spindle fluidity and well suited to support robust chromosome segregation. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020

2017 article

Mapping load-bearing in the mammalian spindle reveals local kinetochore-fiber anchorage that provides mechanical isolation and redundancy

Elting, M. W., Prakash, M., Udy, D. B., & Dumont, S. (2017, January 26). BioRxiv (Cold Spring Harbor Laboratory), Vol. 1.

By: M. Elting* , M. Prakash *, D. Udy & S. Dumont *

topics (OpenAlex): Microtubule and mitosis dynamics; Cellular Mechanics and Interactions; Nuclear Structure and Function
TL;DR: This work maps load-bearing across the mammalian spindle in space-time, and dissects local anchorage mechanics and mechanism, suggesting widespread NuMA-mediated crosslinks locally bear load, providing mechanical isolation and redundancy while allowing spindle fluidity. (via Semantic Scholar)
Source: ORCID
Added: February 22, 2024

2017 journal article

The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregation

The Journal of Cell Biology, 216(6), 1597–1608.

By: T. Karg *, M. Elting* , H. Vicars *, S. Dumont * & W. Sullivan *

Contributors: T. Karg *, M. Elting* , H. Vicars *, S. Dumont * & W. Sullivan *

MeSH headings : Animals; Animals, Genetically Modified; Cell Cycle Proteins / metabolism; Chromosome Segregation; Chromosomes, Insect; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Drosophila melanogaster / metabolism; Kinesins / genetics; Kinesins / metabolism; Microscopy, Confocal; Microscopy, Fluorescence; Microscopy, Video; Microtubules / metabolism; Mutation; Spindle Apparatus / metabolism; Telomere / metabolism; Time Factors
topics (OpenAlex): Microtubule and mitosis dynamics; Genomics and Chromatin Dynamics; Chromosomal and Genetic Variations
TL;DR: It is demonstrated that microtubules play a key role in poleward movement of acentric chromosome fragments generated in Drosophila melanogaster neuroblasts and that successful acentric segregation requires the chromokinesin Klp3a. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020

2016 journal article

Local Anchorage of Kinetochore-Fibers to the Mammalian Spindle Provides Mechanical Isolation and Load-Bearing Redundancy

Biophysical Journal, 110(3), 355a.

By: M. Elting* , D. Udy & S. Dumont *

topics (OpenAlex): Microtubule and mitosis dynamics; Genomics and Chromatin Dynamics; Cellular Mechanics and Interactions
TL;DR: The data indicate that NuMA-mediated microtubule crosslinking in the spindle body allows for local anchorage and isolation of k-fibers, and mechanical redundancy in their connections to theSpindle body, well-suited to ensure robust k-Fiber load-bearing and chromosome segregation despite dynamic spindle forces and structures. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020

2014 journal article

Force on spindle microtubule minus ends moves chromosomes

The Journal of Cell Biology, 206(2), 245–256.

By: M. Elting* , C. Hueschen *, D. Udy * & S. Dumont *

Contributors: M. Elting* , C. Hueschen *, D. Udy * & S. Dumont *

MeSH headings : Animals; Biological Transport; Cell Line; Chromosomes / metabolism; Dynactin Complex; Dyneins / metabolism; Dyneins / physiology; Kinetochores; Microtubule-Associated Proteins / metabolism; Microtubule-Associated Proteins / physiology; Microtubules / metabolism; Microtubules / physiology; Microtubules / ultrastructure; Nuclear Matrix-Associated Proteins / metabolism; Nuclear Matrix-Associated Proteins / physiology; Potoroidae; Spindle Apparatus / metabolism; Spindle Apparatus / physiology; Spindle Apparatus / ultrastructure
topics (OpenAlex): Microtubule and mitosis dynamics; Cellular Mechanics and Interactions; Cellular transport and secretion
TL;DR: After the loss of continuous spindle microtubule attachment to the spindle pole, a previously undescribed mechanism of chromosome transport, powered by dynein pulling on minus ends of severed microtubules, repairs spindle architecture and integrity. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020

2014 journal article

Probing Forces on Newly Generated Spindle Microtubule Minus-Ends

Biophysical Journal, 106(2), 9a–10a.

By: M. Elting* , C. Hueschen *, D. Udy * & S. Dumont *

topics (OpenAlex): Microtubule and mitosis dynamics; Micro and Nano Robotics; Microfluidic and Bio-sensing Technologies
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020

2014 journal article

Probing Forces on Newly Generated Spindle Microtubule Minus-Ends

Biophysical Journal, 106(2), 787a.

By: C. Hueschen, M. Elting* , D. Udy & S. Dumont

topics (OpenAlex): Microtubule and mitosis dynamics; Micro and Nano Robotics; Microfluidic and Bio-sensing Technologies
TL;DR: Laser ablation is used to sever kinetochore-fiber microtubules in mammalian cells and probe how the cell detects and organizes newly generated microtubule minus-ends, indicating that pole-focusing forces are well-suited to robustly maintain spindle structural integrity despite rapid turnover of spindle components and mechanical challenges. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020

2013 article

Single-molecule fluorescence imaging of processive myosin with enhanced background suppression using linear zero-mode waveguides (ZMWs) and convex lens induced confinement (CLIC)

Elting, M. W., Leslie, S. R., Churchman, L. S., Korlach, J., McFaul, C. M. J., Leith, J. S., … Spudich, J. A. (2013, January 10). Optics Express, Vol. 21, pp. 1189–1202.

By: M. Elting* , S. Leslie *, L. Churchman *, J. Korlach*, C. McFaul*, J. Leith*, M. Levene*, A. Cohen *, J. Spudich *

Contributors: M. Elting* , S. Leslie *, L. Churchman *, J. Korlach*, C. McFaul*, J. Leith*, M. Levene*, A. Cohen *, J. Spudich *

MeSH headings : Actins / chemistry; Adenosine Triphosphate / chemistry; Animals; Biophysics / methods; Computer Simulation; Cytoskeleton / metabolism; Dyneins / chemistry; Equipment Design; Insecta; Kinesins / chemistry; Lenses; Microscopy / instrumentation; Microscopy / methods; Microscopy, Fluorescence / methods; Microtubules / chemistry; Myosins / chemistry; Optical Imaging / methods; Physics / methods
topics (OpenAlex): Cardiomyopathy and Myosin Studies; ATP Synthase and ATPases Research; Advanced Fluorescence Microscopy Techniques
TL;DR: Two new single-molecule fluorescence microscopy techniques are demonstrated and applied, linear zero-mode waveguides (ZMWs) and convex lens induced confinement (CLIC), for imaging the processive motion of molecular motors myosin V and VI along actin filaments, which will enable new biophysical measurements of a wide range of processive molecular motors that move along filamentous tracks. (via Semantic Scholar)
Source: ORCID
Added: February 22, 2024

2012 journal article

Future Challenges in Single-Molecule Fluorescence and Laser Trap Approaches to Studies of Molecular Motors

Developmental Cell, 23(6), 1084–1091.

By: M. Elting*  & J. Spudich *

Contributors: M. Elting*  & J. Spudich *

MeSH headings : Cell Movement; Fluorescence; Microscopy, Atomic Force; Microscopy, Fluorescence; Molecular Motor Proteins / chemistry; Molecular Motor Proteins / metabolism; Optical Tweezers
topics (OpenAlex): Force Microscopy Techniques and Applications; Mechanical and Optical Resonators; Advanced Electron Microscopy Techniques and Applications
TL;DR: This work describes two areas where it expects to see exciting developments in the near future: first, characterizing the coupling of force production to chemical and mechanical changes in motors, and second, understanding how multiple motors work together in the environment of the cell. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020

2012 journal article

Single Molecule Studies of Recombinant Human α- and β-Cardiac Myosin to Elucidate Molecular Mechanism of Familial Hypertrophic and Dilated Cardiomyopathies

Biophysical Journal, 102(3), 613a–614a.

By: J. Sung *, E. Choe*, M. Elting* , S. Nag *, S. Sutton *, J. Deacon*, L. Leinwand *, K. Ruppel*, J. Spudich *

topics (OpenAlex): Cardiomyopathy and Myosin Studies; Congenital heart defects research
TL;DR: The first single molecule studies of recombinant human cardiac myosin are demonstrated and a modern version optical trap is built that can resolve the ∼10 nm stroke size and ∼10 ms strongly bound state of cardiac β-S1 at high [ATP]. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020

2011 journal article

Detailed Tuning of Structure and Intramolecular Communication Are Dispensable for Processive Motion of Myosin VI

Biophysical Journal, 100(2), 430–439.

By: M. Elting* , Z. Bryant *, J. Liao * & J. Spudich *

Contributors: M. Elting* , Z. Bryant *, J. Liao * & J. Spudich *

MeSH headings : Actins / chemistry; Actins / metabolism; Adenosine Triphosphatases / chemistry; Adenosine Triphosphatases / metabolism; Animals; Cell Line; Kinetics; Myosin Heavy Chains / chemistry; Myosin Heavy Chains / isolation & purification; Myosin Heavy Chains / metabolism; Myosins / chemistry; Myosins / metabolism; Protein Binding; Protein Structure, Tertiary; Spodoptera / cytology
topics (OpenAlex): Cardiomyopathy and Myosin Studies; Molecular Junctions and Nanostructures; Force Microscopy Techniques and Applications
TL;DR: It is concluded that detailed tuning of structure and intramolecular communication are dispensable for processive motion, and it is shown theoretically that one proposed type of nucleotide gating can be detrimental rather than beneficial for myosin processivity. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020

2010 journal article

Probing Myosin-VI Processivity using Artificial Lever Arms

Biophysical Journal, 98(3), 723a.

By: M. Elting* , Z. Bryant *, J. Liao * & J. Spudich *

topics (OpenAlex): Cardiomyopathy and Myosin Studies; Cellular Mechanics and Interactions; Polymer Surface Interaction Studies
TL;DR: In new chimeric constructs, it is shown that limited processivity is possible even in the absence of both calmodulin-binding regions, and the importance of intra-head coordination for processive motion in myosin VI is examined by comparing the predictions of simple kinetic models to measurements of run length distributions for chimeric myosins and for control contructs. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020

2009 journal article

Engineered Myosin VI Motors Reveal Minimal Structural Determinants of Directionality and Processivity

Journal of Molecular Biology, 392(4), 862–867.

By: J. Liao *, M. Elting* , S. Delp *, J. Spudich * & Z. Bryant *

Contributors: J. Liao *, M. Elting* , S. Delp *, J. Spudich * & Z. Bryant *

author keywords: molecular motor; protein engineering; swinging crossbridge; molecular dynamics; single molecule
MeSH headings : Amino Acid Motifs; Amino Acid Sequence; Biomechanical Phenomena; Computer Simulation; Kinetics; Models, Molecular; Molecular Motor Proteins / chemical synthesis; Molecular Motor Proteins / chemistry; Molecular Motor Proteins / metabolism; Molecular Motor Proteins / physiology; Molecular Sequence Data; Movement / physiology; Myosin Heavy Chains / chemical synthesis; Myosin Heavy Chains / chemistry; Myosin Heavy Chains / genetics; Myosin Heavy Chains / metabolism; Protein Engineering; Protein Multimerization / physiology; Protein Structure, Tertiary / physiology; Sequence Homology, Amino Acid
topics (OpenAlex): Cardiomyopathy and Myosin Studies; Cellular Mechanics and Interactions; Force Microscopy Techniques and Applications
TL;DR: E engineered M6 motors are used to test and refine the "redirected power stroke" model for (-) end directionality and to explore poorly understood structural requirements for processive stepping, and an 18-residue alpha-helical insert is found to reverse the directionality of the motor. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020

2007 article

Rapid Membrane Fusion of Individual Virus Particles with Supported Lipid Bilayers

Wessels, L., Elting, M. W., Scimeca, D., & Weninger, K. (2007, April 21). Biophysical Journal, Vol. 93, pp. 526–538.

By: L. Wessels  n, M. Elting n , D. Scimeca n & K. Weninger n 

Contributors: L. Wessels  n, M. Elting n , D. Scimeca n & K. Weninger n 

MeSH headings : Animals; Biophysical Phenomena; Biophysics; Chick Embryo; Cricetinae; Fluorescent Dyes; Hydrogen-Ion Concentration; In Vitro Techniques; Influenza A Virus, H3N2 Subtype / physiology; Lipid Bilayers / chemistry; Membrane Fusion / physiology; Models, Biological; Rhodamines; Sindbis Virus / physiology; Virion / physiology
topics (OpenAlex): Lipid Membrane Structure and Behavior; Influenza Virus Research Studies; RNA and protein synthesis mechanisms
TL;DR: A fluorescence assay using single particle tracking is introduced to observe lipid mixing between individual virus particles (influenza or Sindbis) and supported lipid bilayers to highlight the complex interaction between lipids, virus proteins, and buffer conditions in membrane fusion. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018

Employment

Updated: February 22nd, 2024 08:22

2023 - present

North Carolina State University Raleigh, US
Associate Professor Physics

2017 - 2023

North Carolina State University Raleigh, US
Assistant Professor Physics

2012 - 2017

University of California, San Francisco San Francisco, US
Postdoc, Dumont Lab Cell and Tissue Biology

Education

Updated: September 11th, 2021 09:47

2006 - 2012

Stanford University Stanford, CA, US
Ph.D. Applied Physics

2006 - 2009

Stanford University Stanford, California, US
M.S. Applied Physics

2003 - 2006

North Carolina State University Raleigh, North Carolina, US
B.S. Physics

Funding History

Funding history based on the linked ORCID record. Updated: October 16th, 2024 15:05

grant June 1, 2023 - May 31, 2027
Collaborative Research: Understanding and controlling force generation by a centrin-based contractile system
Directorate for Biological Sciences
grant June 15, 2022 - May 31, 2026
Collaborative Research: MODULUS: Nuclear envelope shape change coordination with chromosome segregation in mitosis in fission yeast
Directorate for Biological Sciences
grant September 1, 2020 - August 31, 2025
Microtubule bundles in the mitotic spindle: probing how mechanical and functional robustness emerge from molecular architecture
National Institute of General Medical Sciences
grant September 1, 2019 - August 31, 2023
Collaborative Research: CYBORG cells: Modular integration of synthetic organelles into living cells
Directorate for Biological Sciences

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