Nancy A Monteiro-Riviere

Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in rats

Particle and Fibre Toxicology, 19(1).

Perspectives of nanotoxicology: Introduction

[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 14(6).

Predicting Nanoparticle Delivery to Tumors Using Machine Learning and Artificial Intelligence Approaches

INTERNATIONAL JOURNAL OF NANOMEDICINE, 17, 1365–1379.

The synergistic strategies for the immuno‐oncotherapy with photothermal nanoagents

WIREs Nanomedicine and Nanobiotechnology, 13(5).

Amino/Amido Conjugates Form to Nanoscale Cobalt Physiometacomposite (PMC) Materials Functionally Delivering Nucleic Acid Therapeutic to Nucleus Enhancing Anticancer Activity via Ras-Targeted Protein Interference

ACS Applied Bio Materials, 3(1), 175–179.

Gold Nanoparticles Induce Cell Stress by Interfering with the Cellular Protein Quality Control System

Gold Nanoparticles Induce Cell Stress by Interfering with the Cellular Protein Quality Control System

ResearchSquare.

Meta-Analysis of Nanoparticle Delivery to Tumors Using a Physiologically Based Pharmacokinetic Modeling and Simulation Approach

ACS Nano, 14(3), 3075–3095.

Toxicity assessment of six titanium dioxide nanoparticles in human epidermal keratinocytes

Cutaneous and Ocular Toxicology, 38(1), 66–80.

Modeling gold nanoparticle biodistribution after arterial infusion into perfused tissue: effects of surface coating, size and protein corona

Nanotoxicology, 12(10), 1093–1112.

Probabilistic risk assessment of gold nanoparticles after intravenous administration by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling

Nanotoxicology, 12(5), 453–469.

Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation

Nanotoxicology, 11(9-10), 1157–1175.

Biocorona formation on gold nanoparticles modulates human proximal tubule kidney cell uptake, cytotoxicity and gene expression

Toxicology in Vitro, 42, 150–160.

Multi-walled carbon nanotube exposure alters protein expression in human keratinocytes

In Nanomedicine in Cancer (pp. 461–485).

Skin

In Adverse Effects of Engineered Nanomaterials (pp. 357–380).

Surface chemistry of gold nanoparticles determines the biocorona composition impacting cellular uptake, toxicity and gene expression profiles in human endothelial cells

Nanotoxicology, 11(4), 507–519.

A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles

Nanomedicine, 11(2), 107–119.

A physiologically based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice

Nanotoxicology, 10(2), 162–172.

Assessing the safety of cosmetic chemicals: Consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)

Regulatory Toxicology and Pharmacology, 76, 174–186.

Biocorona Bound Gold Nanoparticles Augment Their Hematocompatibility Irrespective of Size or Surface Charge

ACS Biomaterials Science & Engineering, 2(9), 1608–1618.

Cell and Protein Interactions with Diamond

In R. Bawa, G. F. Audette, & B. Reese (Eds.), Handbook of Clinical Nanomedicine: Law, Business, Regulation, Safety and Risk (pp. 809–822).

Intracellular imaging of quantum dots, gold, and iron oxide nanoparticles with associated endocytic pathways

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 9(2), e1419.

Mechanisms of cell uptake, inflammatory potential and protein corona effects with gold nanoparticles

Nanomedicine, 11(24), 3185–3203.

Mechanistic Toxicity Assessment of Hexahydroisohumulone in Canine Hepatocytes, Renal Proximal Tubules, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like Cells

International Journal of Veterinary Health Science & Research, 4(2), 88–103.

Nanomedicine: Ethical considerations

In Handbook of Clinical Nanomedicine: Law, Business, Regulation, Safety, and Risk (Vol. 2, pp. 1031–1055).

Oxidative stress response in canine in vitro liver, kidney and intestinal models with seven potential dietary ingredients

Toxicology Letters, 241, 49–59.

Protein corona modulation of hepatocyte uptake and molecular mechanisms of gold nanoparticle toxicity

Nanotoxicology, 11(1), 64–75.

Quantification of nanoparticle pesticide adsorption: computational approaches based on experimental data

Nanotoxicology, 10(8), 1118–1128.

Safety of Nanoparticle Skin Penetration

In Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement (pp. 363–376).

Toxicological effects of pet food ingredients on canine bone marrow-derived mesenchymal stem cells and enterocyte-like cells

Journal of Applied Toxicology, 36(2), 189–198.

Biomedical applications of gold nanomaterials: opportunities and challenges

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 7(6), 779–796.

Comparative In Vitro Cytotoxicity of 20 Potential Food Ingredients in Canine Liver, Kidney, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like Cells

Applied In Vitro Toxicology, 1(4), 276–288.

Dermatotoxicity of Nanomaterials

In B. Fadeel (Ed.), Handbook of Safety Assessment of Nanomaterials: From Toxicological Testing to Personalized Medicine (pp. 439–459,). Boca Raton, FL: Jenny Stanford Publishing.

Gold and silver nanoparticle interactions with human proteins: impact and implications in biocorona formation

Journal of Materials Chemistry B, 3(10), 2075–2082.

In Vitro and In Vivo Toxicity and Pharmacokinetics of Silver Nanoparticles

In Encyclopedia of Nanotechnology (pp. 1–14).

In vitro safety assessment of food ingredients in canine renal proximal tubule cells

Toxicology in Vitro, 29(2), 289–298.

Predicting the impact of biocorona formation kinetics on interspecies extrapolations of nanoparticle biodistribution modeling

Nanomedicine, 10(1), 25–33.

Safety assessment of potential food ingredients in canine hepatocytes

Food and Chemical Toxicology, 78, 105–115.

Dermal Exposure and Absorption of Chemicals and Nanomaterials

In Reference Module in Biomedical Sciences.

Growth of zircone on nanoporous alumina using molecular layer deposition

JOM: the Journal of the Minerals, Metals & Materials Society, 66(4), 649–653.

In vitro biocompatibility and antibacterial efficacy of a degradable poly(L-lactide-co-epsilon-caprolactone) copolymer incorporated with silver nanoparticles

Annals of Biomedical Engineering, 42(7), 1482–1493.

Nanoparticle Surface Characterization and Clustering through Concentration-Dependent Surface Adsorption Modeling

ACS Nano, 8(9), 9446–9456.

Nanotoxicology: Progress toward Nanomedicine

(2nd ed.; N. A. Monteiro-Riviere & C. L. Tran, Eds.).

Pharmacokinetics of metallic nanoparticles

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 7(2), 189–217.

Safety Implications of Nanomaterial Exposure to Skin

In N. A. Monteiro-Riviere & C. L. Tran (Eds.), Nanotoxicology: Progress toward nanomedicine (2nd ed., pp. 267–292).

Silver Nanoparticles in Biomedical Applications

In N. A. Monteiro-Riviere & C. Lang Tran (Eds.), Nanotoxicology: Progress toward Nanomedicine (2nd ed., pp. 425–442).

Two-photon polymerization/micromolding of microscale barbs for medical applications

Journal of Adhesion Science and Technology, 28(3-4), 387–398.

Biocompatibility analysis of an electrically-activated silver-based antibacterial surface system for medical device applications

Journal of Materials Science. Materials in Medicine, 24(3), 755–760.

Computational approaches and metrics required for formulating biologically realistic nanomaterial pharmacokinetic models

Computational Science & Discovery, 6(1), 014005.

Nanomaterials and synergistic low-intensity direct current (LIDC) stimulation technology for orthopedic implantable medical devices

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology, Vol. 5, pp. 191–204.

Oxidative stress and dermal toxicity of iron oxide nanoparticles in vitro

Cell Biochemistry and Biophysics, 67(2), 461–476.

Predicting skin permeability from complex vehicles

Advanced Drug Delivery Reviews, Vol. 65, pp. 265–277.

Protein binding modulates the cellular uptake of silver nanoparticles into human cells: Implications for in vitro to in vivo extrapolations?

Toxicology Letters, 220(3), 286–293.

Skin Penetration of Engineered Nanomaterials

In E. A. Nasir, A. Friedman, & S. Wang (Eds.), Nanotechnology in Dermatology (Vol. 9781461450344, pp. 51–61).

The effects of geometry on skin penetration and failure of polymer microneedles

Journal of Adhesion Science and Technology, 27(3), 227–243.

Acute vascular effects of nanoparticle infusion in isolated perfused skin

Nanomedicine: Nanotechnology, Biology and Medicine, 8(4), 428–431.

Challenges obtaining a biowaiver for topical veterinary dosage forms

Journal of Veterinary Pharmacology and Therapeutics, 35(SUPPL. 1), 103–114.

Effects of Engineered Nanomaterials on Skin

In B. Fadeel, A. Pietroiusti, & A. Shvedova (Eds.), Adverse Effects of Engineered Nanomaterials : Exposure, Toxicology, and Impact on Human Health (pp. 185–207). Burlington: Elsevier Science.

Effects of eight nanoparticles of different sizes and shapes on human epidermal keratinocytes

Journal of Investigative Dermatology, 132, S52. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000302866900308&KeyUID=WOS:000302866900308

In Vitro and In Vivo Toxicity of Silver Nanoparticles

In E. B. Bhushan) (Ed.), Encyclopedia of Nanotechnology (pp. 1069–1077,). Heidelberg, Germany: Springer Verlag.

In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps

Journal of Applied Toxicology, 32(11), 913–919.

LACK OF HYDROXYLATED FULLERENE TOXICITY AFTER INTRAVENOUS ADMINISTRATION TO FEMALE SPRAGUE-DAWLEY RATS

Journal of Toxicology and Environmental Health-Part a-Current Issues, 75(7), 367–373.

Quantum dot penetration into viable human skin

Nanotoxicology, 6(2), 173–185.

Silver nanoparticles do not influence stem cell differentiation but cause minimal toxicity

Nanomedicine, 7(8), 1197–1209.

Skin

In Adverse Effects of Engineered Nanomaterials (pp. 185–207).

Ultrananocrystalline Diamond-Coated Microporous Silicon Nitride Membranes for Medical Implant Applications

JOM, 64(4), 520–525.

Use of confocal microscopy for nanoparticle drug delivery through skin

Journal of Biomedical Optics, 18(6), 061214.

Zinc oxide - nanosize does not change the toxicological profile

Naunyn-Schmiedebergs Archives of Pharmacology, 385, 104. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000300779500460&KeyUID=WOS:000300779500460

Antibacterial efficacy of silver nanoparticles of different sizes, surface conditions and synthesis methods

Nanotoxicology, 5(2), 244–253.

Atomic layer deposition of titanium dioxide on cellulose acetate for enhanced hemostasis

Biotechnology Journal, 6(2), 213–223.

Cellular uptake mechanisms and toxicity of quantum dots in dendritic cells

Nanomedicine, 6(5), 777–791.

Commentary on transcutaneous delivery

Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology, 3(5), 439–440.

Deposition of antimicrobial coatings on microstereolithography-fabricated microneedles

Jom, 63(6), 59–68.

Dermal Penetration of UVB-Damaged Skin by Titanium- and Zincoxide Nanoparticles in Sunscreen Formulations

Naunyn-Schmiedebergs Archives of Pharmacology, 383, 101. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000288573100511&KeyUID=WOS:000288573100511

In vitro toxicity assessment of three hydroxylated fullerenes in human skin cells

Toxicology in Vitro, 25(8), 2105–2112.

Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing

Biomicrofluidics, 5(1), 013415.

Mapping the Surface Adsorption Forces of Nanomaterials in Biological Systems

Acs Nano, 5(11), 9074–9081.

Modification of microneedles using inkjet printing

AIP Advances, 1(2), 022139.

Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles

Faraday Discussions, 149, 171–185.

Safety Evaluation of Sunscreen Formulations Containing Titanium Dioxide and Zinc Oxide Nanoparticles in UVB Sunburned Skin: An In Vitro and In Vivo Study

Toxicological Sciences, 123(1), 264–280.

Absorption, Penetration, and Cutaneous Toxicity of Jet Fuels and Hydrocarbon Components

In Jet Fuel Toxicology (pp. 119–134).

Absorption, penetration, and cutaneous toxicity of jet fuels and hydrocarbon components

In Jet Fuel Toxicology (pp. 119–134).

An index for characterization of nanomaterials in biological systems

Nature Nanotechnology, 5(9), 671–675.

Atomic layer deposition of nanoporous biomaterials

Materials Today, 13(3), 60–64.

Atomic layer deposition-based functionalization of materials for medical and environmental health applications

Philosophical Transactions of the Royal Society a-Mathematical Physical and Engineering Sciences, 368(1917), 2033–2064.

CYTOKINE AND CHEMOKINE LEVELS IN SERUM AND CEREBROSPINAL FLUID OF DOGS WITH INFLAMMATORY CENTRAL NERVOUS SYSTEM DISEASE

Journal of Veterinary Internal Medicine, 24(3), 741. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000277416600262&KeyUID=WOS:000277416600262

Characterization of Toxicoproteomics Maps for Chemical Mixtures Using Information Theoretic Approach

In Principles and Practice of Mixtures Toxicology (pp. 215–234).

Dermal Exposure and Absorption of Chemicals and Nanomaterials*

In Comprehensive Toxicology (Vol. 1-14, pp. 111–122).

EVALUATION OF CYTOKINE AND CHEMOKINE LEVELS IN CANINE INTRACRANIAL NEOPLASIA

Journal of Veterinary Internal Medicine, 24(3), 741. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000277416600264&KeyUID=WOS:000277416600264

Evaluating the risks associated with nanomaterials

In E. A. V. Narlikar & Y. Y. Du (Eds.), The Oxford Handbook of Nanoscience and Technology, Frontiers and Advances: Vol. III (pp. 888–906,). Oxford: Oxford University Press.

Evaluation of Silver Nanoparticle Toxicity in Skin in Vivo and Keratinocytes in Vitro

Environmental Health Perspectives, 118(3), 407–413.

Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles

Toxicology Letters, 197(1), 1–6.

Fabrication of Microneedles Using Two Photon Polymerization for Transdermal Delivery of Nanomaterials

Journal of Nanoscience and Nanotechnology, 10(10), 6305–6312.

In vitro biocompatibility of titanium alloy discs made using direct metal fabrication

Medical Engineering & Physics, 32(6), 645–652.

Interactions of aluminum nanoparticles with human epidermal keratinocytes

Journal of Applied Toxicology, 30(3), 276–285.

Intrinsic biological property of colloidal fullerene nanoparticles (nC(60)): Lack of lethality after high dose exposure to human epidermal and bacterial cells

Toxicology Letters, 197(2), 128–134.

Lectins modulate multi-walled carbon nanotubes cellular uptake in human epidermal keratinocytes

Toxicology in Vitro, 24(2), 546–551.

Nanomaterial penetration

In Toxicology of the Skin (pp. 333–346). http://www.scopus.com/inward/record.url?eid=2-s2.0-77958477177&partnerID=MN8TOARS

Nanomaterials Penetration

In N. A. Monteiro-Riviere (Ed.), Toxicology of the Skin (pp. 333–346). New York, NY: Informa Healthcare.

Potential Arsenic Exposure Through Dermal Penetration

In N. A. Monteiro-Riviere) (Ed.), Toxicology of the Skin (pp. 347–360). http://www.scopus.com/inward/record.url?eid=2-s2.0-85056392662&partnerID=MN8TOARS

Preface

In Toxicology of the Skin (p. v). http://www.scopus.com/inward/record.url?eid=2-s2.0-85060190964&partnerID=MN8TOARS

Skin penetration and kinetics of pristine fullerenes (C-60) topically exposed in industrial organic solvents

Toxicology and Applied Pharmacology, 242(1), 29–37.

Structure and Function of Skin

In N. A. Monteiro-Riviere (Ed.), Toxicology of the Skin (pp. 1–18,). http://www.scopus.com/inward/record.url?eid=2-s2.0-85056380325&partnerID=MN8TOARS

Toxicology of the skin

New York, NY: Informa Healthcare.

Toxicology of the skin

In Toxicology of the Skin (pp. 1–437). http://www.scopus.com/inward/record.url?eid=2-s2.0-84868687035&partnerID=MN8TOARS

Two Photon Polymerization-Micromolding of Polyethylene Glycol-Gentamicin Sulfate Microneedles

Advanced Engineering Materials, 12(4), B77–B82.

ASSESSMENT OF QUANTUM DOT PENETRATION INTO SKIN IN DIFFERENT SPECIES UNDER DIFFERENT MECHANICAL ACTIONS

Nanomaterials: Risks and Benefits, 43–52.

Assessing the antimicrobial activity of zinc oxide thin films using disk diffusion and biofilm reactor

Applied Surface Science, 255(11), 5806–5811.

Atomic layer deposition of TiO2 thin films on nanoporous alumina templates: Medical applications

Jom, 61(6), 12–16.

Comparison of Quantum Dot Biodistribution with a Blood-Flow-Limited Physiologically Based Pharmacokinetic Model

Nano Letters, 9(2), 794–799.

Comparison of quantum dot biodistribution with a blood-flow-limited physiologically based pharmacokinetic model

Nano Letters, 9(2), 794–799.

Cutaneous Toxicology

Endocytic mechanisms and toxicity of a functionalized fullerene in human cells

Toxicology Letters, 191(2-3), 149–157.

Expression of Proinflammatory Cytokines by Human Mesenchymal Stem Cells in Response to Cyclic Tensile Strain

Journal of Cellular Physiology, 219(1), 77–83.

Fabrication of Polymer Microneedles Using a Two-Photon Polymerization and Micromolding Process

Journal of Diabetes Science and Technology, 3(2), 304–311.

HUMAN HEALTH RISKS OF ENGINEERED NANOMATERIALS Critical Knowledge Gaps in Nanomaterials Risk Assessment

Nanomaterials: Risks and Benefits, 3–29.

Human health risks of engineered nanomaterials

In Nanomaterials: Risks and benefits (pp. 1–28). Dordrecht, Holland: Springer.

Interaction of nanomaterials with skin: Aspects of absorption and biodistribution

Nanotoxicology, 3(3), 188–193.

Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line

Toxicology and Applied Pharmacology, 234(2), 222–235.

Mechanisms of Quantum Dot Nanoparticle Cellular Uptake

Toxicological Sciences, 110(1), 138–155.

Microfabricated curtains for controlled cell seeding in high throughput microfluidic systems

Lab on a Chip, 9(12), 1756–1762.

Nanoporous membranes for medical and biological applications

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 1(5), 568–581.

Pulsed laser deposition of antimicrobial silver coating on Ormocer (R) microneedles

Biofabrication, 1(4).

Pulsed laser deposition of antimicrobial silver coating on Ormocer microneedles.

Biofabrication, 1(4), 041001. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:20661316&KeyUID=MEDLINE:20661316

Rapid prototyping of scaphoid and lunate bones

Biotechnology Journal, 4(1), 129–134.

Review of Federal Strategy for Nanotechnology-Related Environmental, Health, and Safety Research

Stretchable diamond-like carbon microstructures for biomedical applications

Jom, 61(9), 53–58.

Anatomical factors that affect barrier function

In K. P. W. H. Zhai & H. I. Maibach (Eds.), Dematotoxicology (7th ed.) (pp. 39–50). Boca Raton: Wiley & Sons.

Animal skin morphology and dermal absorption

In M. S. Roberts & K. A. Walters (Eds.), Dermal absorption and toxicity assessment (2nd ed., pp. 17–35). New York: Informa Healthcare.

Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin

Skin Pharmacology and Physiology, 21(3), 166–180.

Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes

Toxicology and Applied Pharmacology, 228(2), 200–211.

COLL 95-Assessment of quantum dot nanoparticle penetration in human skin

Abstracts of Papers of the American Chemical Society, 236. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000270256303852&KeyUID=WOS:000270256303852

Characterization of microfluidic human epidermal keratinocyte culture

Cytotechnology, 56(3), 197–207.

Cyclic tensile strain increases interactions between human epidermal keratinocytes and quantum dot nanoparticles

Toxicology in Vitro, 22(2), 491–497.

Dermatotoxicology

In R. C. Smart & E. Hodgson (Eds.), Molecular and biochemical toxicology (4th ed.) (pp. 851–880).

Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes

Journal of Applied Toxicology, 28(4), 543–553.

Mechanical and biological properties of nanoporous carbon membranes

Biomedical Materials, 3(3).

Nanoceria as antioxidant: Synthesis and biomedical applications

Jom, 60(3), 33–37.

Solvents and vehicle effects on the skin

In M. S. Roberts & K. A. Walters (Eds.), Dermal absorption and toxicity assessment. (2nd ed.) (pp. 433–447). New York: Informa Healthcare.

Topical isoflavones provide effective photoprotection to skin

Photodermatology Photoimmunology & Photomedicine, 24(2), 61–66.

Toxicological impacts of nanomaterials

In M. R. Wiesner & J. Y. Bottero (Eds.), Environmental nanotechnology: Applications and impacts of nanomaterials (pp. 395–444). New York: McGraw-Hill.

A linear dilution microfluidic device for cytotoxicity assays

Lab on a Chip, 7(2), 226–232.

A system coefficient approach for quantitative assessment of the solvent effects on membrane absorption from chemical mixtures

Sar and Qsar in Environmental Research, 18(5-6), 579–593.