Nancy A Monteiro-Riviere
Also known as: N.A. Monteiro-Riviere; Nancy A Monteiro-Riviere; Monteiro-Riviere NA
nanoparticle toxicity, protein corona, nanotoxicology, skin absorption, toxicity, skin penetration
Nancy A. Monteiro-Riviere PhD, ATS, was the Regents Distinguished Research Scholar and University Distinguished Professor and Founding Director of the Nanotechnology Innovation Center of Kansas State. She did a postdoctoral fellowship in toxicology at Chemical Industry Institute of Toxicology in RTP, NC. She was Professor of Investigative Dermatology and Toxicology at North Carolina State University (NCSU) for 28 years and Professor in the Joint Department of Biomedical Engineering at UNC-Chapel Hill/NCSU and Research Adjunct Professor of Dermatology, at UNC-Chapel Hill School of Medicine. She was past-President of both the Dermal and In Vitro Specialty sections of the Society of Toxicology and selected as an Eminent Toxicologist in March 2016 by the National Society of Toxicology. Dr. Monteiro-Riviere is a Fellow in The Academy of Toxicological Sciences and was elected to its Board of Directors. She was the recipient of the Purdue University Inaugural Distinguished Women Scholars Award, KSU Woman of Distinction, and elected to attend the National Academy of Sciences Keck Futures Initiative. She is Associate Editor for two and serves on the editorial board of six other toxicology journals; as well as on several national (NRC) and international (EU) expert review panels. She was on Thomson Reuters’s 2014 list of the top 1% most highly cited researchers in pharmacology and toxicology. She published over 330 manuscripts in skin toxicology and nanotoxicology and is Editor of three books in toxicology: “Nanotoxicology Characterization and Dosing and Health Effects”, “Toxicology of the Skin -Target Organ Series” and the latest in CRC Press “Nanotoxicology: Progress toward Nanomedicine”. Her research interests involve in vivo and in vitro studies of skin absorption, penetration and toxicity of chemicals, nanoparticles, and the effect of the biocorona on uptake and cellular responses to nanomaterials.
Works (388)
Updated: September 8th, 2024 06:22
2024 journal article
Predicting tissue distribution and tumor delivery of nanoparticles in mice using machine learning models
JOURNAL OF CONTROLLED RELEASE, 374, 219–229.
author keywords: Nanoparticles; Artificial intelligence; Machine learning; Nanomedicine; Drug delivery; Biodistribution; Quantitative structure-activity relationship; (QSAR); Deep neural network model
open access via doi.org (publisher)
Sources: Web Of Science, NC State University Libraries
Added: September 3, 2024
2023 journal article
An artificial intelligence-assisted physiologically-based pharmacokinetic model to predict nanoparticle delivery to tumors in mice
JOURNAL OF CONTROLLED RELEASE, 361, 53–63.
author keywords: Artificial intelligence; Machine learning; Physiologically based pharmacokinetic; modeling; Nanomedicine; Drug delivery; Nanotechnology
TL;DR:
An AI-assisted physiologically based pharmacokinetic (PBPK) model is established by integrating an AI-based quantitative structure-activity relationship (QSAR) model with a PBPK model to simulate tumor-targeted delivery efficiency (DE) and biodistribution of various NPs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 7, 2023
2023 journal article
Meta-Analysis of Nanoparticle Distribution in Tumors and Major Organs in Tumor-Bearing Mice
ACS NANO, 17(20), 19810–19831.
author keywords: Nanoparticle; Tumor delivery; Tissue distribution; Cancer; Nanomedicine
TL;DR:
An updated version of “Nano-Tumor Database” is reported, which increases the number of time-dependent concentration data sets for different nanoparticles (NPs) in tumors from the previous version of 376 data sets to 534 data sets with 2345 data points from 297 studies published from 2005 to 2021.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 10, 2023
2022 journal article
Biocorona modulates the inflammatory response induced by gold nanoparticles in human epidermal keratinocytes
Toxicology Letters, 369, 34–42.
MeSH headings : Antioxidants; Gold / chemistry; Gold / toxicity; Humans; Keratinocytes / metabolism; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; NF-E2-Related Factor 2 / genetics; Polyethyleneimine / chemistry; Protein Corona / chemistry; Protein Corona / metabolism; Thioctic Acid / pharmacology
TL;DR:
It is discovered that nuclear factor erythroid-2 related factor (Nrf2), a major regulator of anti-oxidant and anti-inflammatory gene, is the key factor related to the AuNPs induced oxidative stress and inflammation.
(via Semantic Scholar)
Source: ORCID
Added: August 7, 2023
2022 journal article
Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in rats
Particle and Fibre Toxicology, 19(1).
Contributors: W. Chou *, Y. Cheng *, J. Riviere *, * , W. Kreyling * & Z. Lin *
author keywords: Biodistribution; Endocytosis; Gold nanoparticles; Nanomedicine; Nanotoxicology; Physiologically based pharmacokinetic (PBPK) modeling
MeSH headings : Animals; Bayes Theorem; Gold; Metal Nanoparticles; Models, Biological; Rats; Tissue Distribution
TL;DR:
The size and surface area of AuNPs were the main determinants for endocytic/phagocytic uptake rates regardless of the route of administration, while Zeta potential was an important parameter for the estimation of the exocytic release rates following IV administration.
(via Semantic Scholar)
Source: ORCID
Added: September 25, 2022
2022 review
Perspectives of nanotoxicology: Introduction
[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 14(6).
MeSH headings : Nanostructures / toxicity; Nanotechnology
TL;DR:
This Nanotoxicology specialty issue begins with an overview of the methods used to conduct toxicokinetics, dose-response and risk assessment of nanomaterials: methodology, challenges, and future perspectives and specifically focuses on the experimen-tal design of plasma and tissue toxicokinetic.
(via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 23, 2022
2022 journal article
Predicting Nanoparticle Delivery to Tumors Using Machine Learning and Artificial Intelligence Approaches
INTERNATIONAL JOURNAL OF NANOMEDICINE, 17, 1365–1379.
Contributors: Z. Lin n, W. Chou *, Y. Cheng *, C. He *, n & J. Riviere n
author keywords: artificial intelligence; machine learning; physiologically based pharmacokinetic modeling; nanomedicine; drug delivery; nanotechnology
MeSH headings : Artificial Intelligence; Humans; Machine Learning; Nanoparticles; Neoplasms / drug therapy; Neural Networks, Computer
TL;DR:
The deep neural network model adequately predicted the delivery efficiency of different NPs to different tumors and it outperformed all other machine learning methods; including random forest, support vector machine, linear regression, and bagged model methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 30, 2022
2021 journal article
The synergistic strategies for the immuno‐oncotherapy with photothermal nanoagents
WIREs Nanomedicine and Nanobiotechnology, 13(5).
Contributors: Y. Zhang *, G. Zhang *, G. Wang *, L. Wu *, * & Y. Li *
author keywords: immune checkpoints; immuno‐ oncotherapy; nanomaterials; nanoagents; photothermal therapy; synergistic oncotherapy
MeSH headings : Adjuvants, Immunologic; Humans; Immunotherapy; Nanomedicine; Nanostructures; Neoplasms / therapy; Photothermal Therapy
TL;DR:
This review summarizes the recent studies on the synergistic strategies for the immuno-oncotherapy based on photothermal nanoagents and the mechanisms that trigger the systemic anti-tumor immune responses and PTT-synergized immunosuppressive conditions simultaneously.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 26, 2021
2020 journal article
Amino/Amido Conjugates Form to Nanoscale Cobalt Physiometacomposite (PMC) Materials Functionally Delivering Nucleic Acid Therapeutic to Nucleus Enhancing Anticancer Activity via Ras-Targeted Protein Interference
ACS Applied Bio Materials, 3(1), 175–179.
Contributors: R. Delong *, J. Dean *, G. Glaspell*, M. Jaberi-Douraki *, K. Ghosh*, D. Davis*, * , P. Chandran *
author keywords: PMC; ZnO; cobalt; nickel; B16F10; HEK; A375
TL;DR:
Preclinical potential of PMC for delivery of SSO, RBD, or other nucleic acid therapeutic and anticancer peptides is suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 8, 2020
2020 content posted
Gold Nanoparticles Induce Cell Stress by Interfering with the Cellular Protein Quality Control System
TL;DR:
This study for the first time shows that NPs can interfere with the cellular PQC system by impairing ERAD activity, which in turn initiates a cascade of events leading to cell death and inflammation.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: October 16, 2020
2020 article
Gold Nanoparticles Induce Cell Stress by Interfering with the Cellular Protein Quality Control System
ResearchSquare.
Source: ORCID
Added: September 25, 2022
2020 journal article
Meta-Analysis of Nanoparticle Delivery to Tumors Using a Physiologically Based Pharmacokinetic Modeling and Simulation Approach
ACS Nano, 14(3), 3075–3095.
Contributors: Y. Cheng *, C. He *, J. Riviere*, * & Z. Lin *
author keywords: advanced material; drug delivery; nanomedicine; nanoparticle; physiologically based pharmacokinetic modeling; tissue biothstribution; tumor delivery
MeSH headings : Animals; Disease Models, Animal; Drug Carriers / chemistry; Drug Delivery Systems; Gold / administration & dosage; Gold / chemistry; Gold / pharmacokinetics; Injections, Intravenous; Male; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Neoplasms / chemistry; Neoplasms / metabolism; Tissue Distribution
TL;DR:
The potential causes of this poor delivery efficiency were explored using the more mechanistic PBPK perspective applied to a subset of gold nanoparticles and it was found that low delivery efficiency was associated with low distribution and permeability coefficients at the tumor site.
(via Semantic Scholar)
Sources: ORCID, Crossref
Added: March 5, 2020
2018 journal article
Modeling gold nanoparticle biodistribution after arterial infusion into perfused tissue: effects of surface coating, size and protein corona
Nanotoxicology, 12(10), 1093–1112.
Contributors: J. Riviere*, M. Jaberi-Douraki *, J. Lillich*, T. Azizi *, H. Joo*, K. Choi*, R. Thakkar, *
author keywords: Biodistribution; gold nanoparticles; cell uptake; skin; pharmacokinetics; nanoparticle vascular distribution
MeSH headings : Animals; Epigastric Arteries; Female; Free Tissue Flaps; Gold / administration & dosage; Gold / chemistry; Gold / pharmacokinetics; Humans; Infusions, Intra-Arterial; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Models, Biological; Nanomedicine; Particle Size; Perfusion; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / chemistry; Skin / blood supply; Skin / metabolism; Surface Properties; Swine; Thioctic Acid / chemistry; Tissue Distribution
TL;DR:
These studies paralleled previous in vitro cell culture studies using the same AuNP in human endothelial and renal proximal tubule cells, hepatocytes, keratinocytes, showing BPEI-AuNP having the greatest uptake, although the presence of a PPC did not reduce IPPSF biodistribution as in the cellculture studies.
(via Semantic Scholar)
Sources: ORCID, Crossref
Added: June 27, 2019
2018 journal article
Probabilistic risk assessment of gold nanoparticles after intravenous administration by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling
Nanotoxicology, 12(5), 453–469.
Contributors: Y. Cheng *, J. Riviere*, * & Z. Lin *
author keywords: Gold nanoparticle; computational nanotoxicology; physiologically based pharmacokinetic modeling; probabilistic risk assessment
MeSH headings : Administration, Intravenous; Animals; Bayes Theorem; Gold / administration & dosage; Gold / pharmacokinetics; Gold / toxicity; Humans; Metal Nanoparticles / toxicity; Models, Biological; Monte Carlo Method; Risk Assessment
TL;DR:
The results suggest that under the highest dosing level employed in existing animal studies (worst-case scenario), AuNPs coated with branched polyethylenimine (BPEI) would likely induce ∼90–100% cellular death, implying high cytotoxicity compared to <10% cell death induced by low-to-medium animal dosing levels, which are commonly used in animal studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref
Added: June 27, 2019
2018 journal article
Toxicity assessment of six titanium dioxide nanoparticles in human epidermal keratinocytes
Cutaneous and Ocular Toxicology, 38(1), 66–80.
Contributors: L. Zhang * & *
author keywords: Titanium dioxide nanoparticles; human epidermal keratinocytes; cell viability; cytokine release; cellular uptake
MeSH headings : Cells, Cultured; Cytokines / metabolism; Humans; Keratinocytes / drug effects; Keratinocytes / metabolism; Metal Nanoparticles / toxicity; Titanium / toxicity
TL;DR:
Based on cell viability, only sample B was slightly cytotoxic to HEK and samples B and A* have the potential to cause inflammation indicated by an increase in IL-6.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: June 27, 2019
2017 journal article
Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation
Nanotoxicology, 11(9-10), 1157–1175.
Contributors: Y. Li *, Z. Shi *, I. Radauer-Preiml*, A. Andosch*, E. Casals *, U. Luetz-Meindl*, M. Cobaleda*, Z. Lin *
author keywords: Nano-immunosafety; endotoxin contamination; biocorona modulation; gold nanoparticles; inflammatory effects
MeSH headings : Adsorption; Blood Proteins / chemistry; Computational Biology; Gold / chemistry; Gold / toxicity; HEK293 Cells; Humans; Inflammation; Interleukin-1 / biosynthesis; Lipopolysaccharides / chemistry; Lipopolysaccharides / toxicity; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Models, Biological; Monocytes / drug effects; Monocytes / immunology; Particle Size; Protein Corona / analysis; Surface Properties
TL;DR:
The unintentional adsorption of LPS onto the NP surface can affect the biocorona formation and the inflammatory properties of NPs.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2017 journal article
Biocorona formation on gold nanoparticles modulates human proximal tubule kidney cell uptake, cytotoxicity and gene expression
Toxicology in Vitro, 42, 150–160.
author keywords: Gold nanoparticles; Human proximal tubule cells; Protein corona; Cellular uptake; Gene expression; Mechanisms of toxicity
MeSH headings : Cells, Cultured; Cytokines / metabolism; Gene Expression / drug effects; Gold / administration & dosage; Gold / chemistry; Gold / toxicity; Humans; Kidney Tubules, Proximal / cytology; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Plasma / chemistry; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / chemistry; Serum Albumin / chemistry; Thioctic Acid / chemistry
TL;DR:
These studies clearly showed reduced uptake and cytotoxicity, as well as differentiated gene expression of AuNP with PCs, questioning the utility of in vitro studies using bare NP to assess in vivo effects, suggesting the relative safety of PEG and LA-AuNP as nanomedicine constructs.
(via Semantic Scholar)
Sources: ORCID, Crossref
Added: June 27, 2019
2017 chapter
Multi-walled carbon nanotube exposure alters protein expression in human keratinocytes
In Nanomedicine in Cancer (pp. 461–485).
Source: ORCID
Added: September 25, 2022
2017 chapter
TL;DR:
The role of the skin as a potential route of exposure to nanomaterials is described in the present chapter and in vitro systems and differences in animal species provide limitations for a complete understanding of nanoparticle penetration through the skin.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 26, 2021
2017 journal article
Surface chemistry of gold nanoparticles determines the biocorona composition impacting cellular uptake, toxicity and gene expression profiles in human endothelial cells
Nanotoxicology, 11(4), 507–519.
Contributors: P. Chandran *, J. Riviere* & *
author keywords: Biocorona; gold nanoparticles; surface chemistry; endothelial cells; mechanistic toxicology
MeSH headings : Albumins / metabolism; Cell Survival / drug effects; Circular Dichroism; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Gold / chemistry; Gold / toxicity; Human Umbilical Vein Endothelial Cells; Humans; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Particle Size; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / metabolism; Proteomics; Surface Properties; Transcriptome / drug effects
TL;DR:
NP surface chemistry is shown to play the dominant role over size in determining the biocorona composition, which in turn modulates cell uptake, and biological responses, consequently defining the potential safety and efficacy of nanoformulations.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID, Web Of Science
Added: April 29, 2021
2016 journal article
Assessing the safety of cosmetic chemicals: Consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)
Regulatory Toxicology and Pharmacology, 76, 174–186.
Contributors: F. Williams *, H. Rothe, G. Barrett*, A. Chiodini *, J. Whyte*, M. Cronin *, * , J. Plautz
author keywords: Threshold of Toxicological Concern (TTC); Dermal; Cosmetic chemical; Systemic bioavailability; Decision tree; Prediction; Flux
MeSH headings : Administration, Cutaneous; Administration, Oral; Algorithms; Animals; Biological Availability; Consumer Product Safety; Cosmetics / administration & dosage; Cosmetics / pharmacokinetics; Cosmetics / toxicity; Decision Trees; Dose-Response Relationship, Drug; Humans; Intestinal Absorption; Models, Biological; No-Observed-Adverse-Effect Level; Risk Assessment; Skin / metabolism; Skin Absorption; Toxicity Tests / methods
TL;DR:
The objective here was to explore the potential refinement of exposure for applying the oral TTC to chemicals found in cosmetic products, for which there are limited dermal absorption data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2016 journal article
Biocorona Bound Gold Nanoparticles Augment Their Hematocompatibility Irrespective of Size or Surface Charge
ACS Biomaterials Science & Engineering, 2(9), 1608–1618.
Contributors: A. Sasidharan *, P. Chandran * & *
author keywords: gold nanoparticles; nanoparticle surface chemistry; protein corona; hematotoxicity; blood components
TL;DR:
It is suggested that, irrespective of the physicochemical properties, the adsorption of the PC over AuNP significantly influences its biological impact by alleviating adverse hematotoxicity of bare NP.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2016 chapter
Cell and Protein Interactions with Diamond
In R. Bawa, G. F. Audette, & B. Reese (Eds.), Handbook of Clinical Nanomedicine: Law, Business, Regulation, Safety and Risk (pp. 809–822).
Ed(s): R. Bawa, G. Audette & B. Reese
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: December 6, 2018
2016 journal article
Intracellular imaging of quantum dots, gold, and iron oxide nanoparticles with associated endocytic pathways
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 9(2), e1419.
Contributors: D. Chen *, * & L. Zhang *
MeSH headings : Animals; Cell Line; Cell Membrane / chemistry; Cell Membrane / metabolism; Endocytosis / physiology; Gold; Humans; Intracellular Space / chemistry; Intracellular Space / diagnostic imaging; Intracellular Space / metabolism; Membrane Microdomains; Metal Nanoparticles; Mice; Molecular Imaging / methods; Nanomedicine; Quantum Dots
TL;DR:
Knowing the different methodologies used to determine the endocytic pathways will increase the understanding of NP toxicity, cancer cell targeting, and imaging, so that surface coatings can be created for efficient cell uptake of metallic NP with minimal cytotoxicity.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 26, 2021
2016 journal article
Mechanisms of cell uptake, inflammatory potential and protein corona effects with gold nanoparticles
Nanomedicine, 11(24), 3185–3203.
Contributors: Y. Li * & *
author keywords: endocytosis; gold nanoparticles; human epidermal keratinocytes; inflammation; mechanisms of cellular uptake; protein corona
MeSH headings : Blood Proteins / metabolism; Cells, Cultured; Endocytosis / drug effects; Gold / chemistry; Gold / pharmacology; Humans; Inflammation / chemically induced; Inflammation / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Metal Nanoparticles / chemistry; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / metabolism; Thioctic Acid / chemistry
TL;DR:
Results suggest protein coronas significantly affect cellular uptake and inflammatory responses of AuNP, and suggest BPEI-AuNP showed the greatest uptake, while PEG- auNP had the least.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2016 journal article
Mechanistic Toxicity Assessment of Hexahydroisohumulone in Canine Hepatocytes, Renal Proximal Tubules, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like Cells
International Journal of Veterinary Health Science & Research, 4(2), 88–103.
TL;DR:
Investigating organ-specific oxidative stress and the molecular mechanism of toxicity using the pathway-focused DNA array of the hop ingredient hexahydroisohumulone with canine hepatocytes, canine proximal tubule cells, bone marrow-derived mesenchymal stem cells and enterocyte-like cells provides insight into genes altered with HEX exposure and the cell-type specific responses in dogs.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 29, 2021
2016 journal article
Protein corona modulation of hepatocyte uptake and molecular mechanisms of gold nanoparticle toxicity
Nanotoxicology, 11(1), 64–75.
Contributors: K. Choi*, J. Riviere* & *
author keywords: Gold nanoparticles; human hepatocytes; cell uptake; cytochrome P450; mechanisms of action
MeSH headings : Albumins / chemistry; Blood Proteins / chemistry; Cell Survival / drug effects; Dose-Response Relationship, Drug; Gene Expression Profiling; Gold / chemistry; Gold / metabolism; Gold / toxicity; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / metabolism; Reactive Oxygen Species / metabolism; Transcriptome / drug effects
TL;DR:
Human hepatic uptake of 40 and 80 nm AuNP with branched polyethylenimine (BPEI), lipoic acid (LA) and polyethylene glycol (PEG) coatings as well as human plasma protein (HP) and human serum albumin (HSA) coronas was investigated to better understanding of the dramatic effect of protein coronas (PC) on AuNP cellular uptake, cytotoxicity and their underlying molecular mechanisms of action.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 27, 2021
2016 journal article
Quantification of nanoparticle pesticide adsorption: computational approaches based on experimental data
Nanotoxicology, 10(8), 1118–1128.
Contributors: R. Chen *, Y. Zhang *, * & J. Riviere*
author keywords: BSAI; in situ characterization; nanoparticles; pesticide; surface physicochemistry
MeSH headings : Adsorption; Models, Theoretical; Nanoparticles / analysis; Nanoparticles / chemistry; Neural Networks, Computer; Pesticides / analysis; Pesticides / chemistry; Principal Component Analysis; Surface Properties
TL;DR:
The first attempt of the application of such quantitative measures toward environmental endpoints by analyzing the interactions of a selected group of nanomaterials with a variety of pesticides was made and quantitative computational approaches support theApplication of BSAI modeling in the area of environmental contamINANt detection and remediation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2016 chapter
Safety of Nanoparticle Skin Penetration
In Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement (pp. 363–376).
TL;DR:
This review shows the skin is an important route of exposure to nanomaterials after occupational, environmental, and consumer product usage and there are many challenges that must be overcome before nanotechnology is applied to the field of nanomedicine and prior to conducting science-based occupational or environmental exposure risk assessments.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2015 journal article
A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles
Nanomedicine, 11(2), 107–119.
Contributors: Z. Lin *, * , R. Kannan * & J. Riviere*
author keywords: biodistribution; computational nanotoxicology; endocytosis; nanomaterials; PBPK modeling; physiologically based pharmacokinetic modeling; phagocytosis; toxicokinetics
MeSH headings : Animals; Cell Survival / drug effects; Computer Simulation; Dose-Response Relationship, Drug; Environmental Exposure / adverse effects; Gold / pharmacokinetics; Gold / toxicity; Humans; Metabolic Clearance Rate; Mice; Models, Biological; Nanoparticles / toxicity; Rats; Species Specificity; Swine; Tissue Distribution; Toxicity Tests / methods
TL;DR:
These results partially explain the current low translation rate of nanotechnology-based drug delivery systems from mice to humans and may be applied to other nanomaterials and provides guidance to design future translational studies.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2015 journal article
A physiologically based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice
Nanotoxicology, 10(2), 162–172.
Contributors: Z. Lin *, * & J. Riviere *
author keywords: Biodistribution; endocytosis; gold nanoparticles; pharmacokinetics; PBPK modeling
MeSH headings : Animals; Calibration; Computer Simulation; Endocytosis / physiology; Gold / pharmacokinetics; Humans; Metal Nanoparticles / chemistry; Mice; Models, Biological; Particle Size; Polyethylene Glycols / pharmacokinetics; Tissue Distribution
TL;DR:
A membrane-limited physiologically based pharmacokinetic (PBPK) model for polyethylene glycol-coated gold (Au) NPs (PEG- coated AuNPs) was developed in mice, providing useful insights into the size, time, and species dependence of NP pharmacokinetics.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2015 journal article
Biomedical applications of gold nanomaterials: opportunities and challenges
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 7(6), 779–796.
Contributors: A. Sasidharan * & *
MeSH headings : Animals; Biocompatible Materials / chemistry; Biosensing Techniques; Cell Line, Tumor; Diagnostic Imaging; Drug Delivery Systems; Gold / chemistry; Humans; Immunoglobulin G / chemistry; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Nanomedicine / methods; Photochemistry; Photochemotherapy / methods; Spectrum Analysis, Raman; Surface Properties
TL;DR:
This review summarizes the recent research on the applications of AuNM with a focus on biomedical diagnostics and therapeutics and the bio-interaction of these NM with cells and their in vivo responses are presented.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 30, 2021
2015 journal article
Comparative In Vitro Cytotoxicity of 20 Potential Food Ingredients in Canine Liver, Kidney, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like Cells
Applied In Vitro Toxicology, 1(4), 276–288.
TL;DR:
Dose–response cytotoxicity studies and LC50 using alamar blue assays are reported for seven additional compounds: denatonium benzoate, eucalyptol, hexahydro isohumulone, tetrahydroisohumULone, green tea catechin extract, epigallocatechin gallate, and sodium copper chlorophyllin.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 30, 2021
2015 chapter
Dermatotoxicity of Nanomaterials
In B. Fadeel (Ed.), Handbook of Safety Assessment of Nanomaterials: From Toxicological Testing to Personalized Medicine (pp. 439–459,). Boca Raton, FL: Jenny Stanford Publishing.
Ed(s): B. Fadeel
Source: NC State University Libraries
Added: June 12, 2021
2015 journal article
Gold and silver nanoparticle interactions with human proteins: impact and implications in biocorona formation
Journal of Materials Chemistry B, 3(10), 2075–2082.
Contributors: A. Sasidharan *, J. Riviere* & *
TL;DR:
Findings suggest that irrespective of NP surface chemistry or chemical composition, corona proteins at their physiological concentrations interact rather differently; wherein HSA and IgG coronas adsorbed strongly on the NP surface and kept both Au and AgNP well dispersed, while fibrinogen caused rapid, strong and irreversible agglomeration.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 3, 2021
2015 chapter
In Vitro and In Vivo Toxicity and Pharmacokinetics of Silver Nanoparticles
In Encyclopedia of Nanotechnology (pp. 1–14).
Sources: Crossref, NC State University Libraries
Added: April 26, 2021
2015 journal article
Oxidative stress response in canine in vitro liver, kidney and intestinal models with seven potential dietary ingredients
Toxicology Letters, 241, 49–59.
Contributors: K. Choi*, M. Ortega*, B. Jeffery, J. Riviere* & *
author keywords: In vitro canine culture systems; Multiple organ-derived cells; Dietary ingredients; Organ-specific oxidative stress
MeSH headings : Animals; Antioxidants / chemistry; Antioxidants / pharmacology; Bone Marrow Cells / drug effects; Bone Marrow Cells / metabolism; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Food; Food Analysis; Hepatocytes / drug effects; Intestinal Mucosa / metabolism; Intestines / drug effects; Kidney / drug effects; Kidney / metabolism; Kidney Tubules, Proximal / cytology; Kidney Tubules, Proximal / drug effects; Liver / drug effects; Liver / metabolism; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Oxidants / toxicity; Oxidative Stress / drug effects
TL;DR:
The results suggest that organ-specific responses to oxidative stress by these potential prooxidant compounds may implicate a mechanism of their toxicities.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2015 journal article
Safety assessment of potential food ingredients in canine hepatocytes
Food and Chemical Toxicology, 78, 105–115.
Contributors: L. Zhang *, J. Koci *, B. Jeffery, J. Riviere* & *
MeSH headings : Acetaminophen / toxicity; Acrolein / analogs & derivatives; Acrolein / toxicity; Aflatoxin B1 / toxicity; Animal Feed / standards; Animals; Cell Line; Cell Survival / drug effects; Dogs; Down-Regulation; Eugenol / toxicity; Food Analysis; Food Safety; Ginger / chemistry; Ginger / toxicity; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Lethal Dose 50; Oils, Volatile / toxicity; Plant Extracts / toxicity; Plant Oils / toxicity; Plant Roots / chemistry; Plant Roots / toxicity; Rats; Terpenes / toxicity; Thymol / toxicity; Up-Regulation; Xylitol / toxicity
TL;DR:
In vitro assays such as this may be useful for hazard assessment of food ingredients for altered hepatic function, which CYP and heat shock most affected.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 30, 2021
2015 journal article
Toxicological effects of pet food ingredients on canine bone marrow-derived mesenchymal stem cells and enterocyte-like cells
Journal of Applied Toxicology, 36(2), 189–198.
Contributors: M. Ortega*, B. Jeffery, J. Riviere* & *
author keywords: canine; bone marrow stem cells; enterocyte like cells; adult stem cell differentiation; essential oils; cytotoxicity; mesenchymal stem cells; in vitro
MeSH headings : Acrolein / analogs & derivatives; Acrolein / toxicity; Animal Feed / toxicity; Animals; Bone Marrow / drug effects; Citric Acid / toxicity; Clove Oil / toxicity; Cytotoxins / toxicity; Dogs; Enterocytes / drug effects; Eugenol / toxicity; Ginger / toxicity; Guanosine Monophosphate / toxicity; Inosine Monophosphate / toxicity; Mesenchymal Stem Cells / drug effects; Oils, Volatile / toxicity; Pets; Plant Oils / toxicity; Plant Roots / toxicity; Sorbose / toxicity; Thymol / toxicity
TL;DR:
These studies provide a baseline against which differential toxicity of dietary feed ingredients can be assessed in vitro for direct effects on canine cells and demonstrate differential toxicity in differentiated cells that represent gastrointestinal epithelial cells.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2014 chapter
Dermal Exposure and Absorption of Chemicals and Nanomaterials
In Reference Module in Biomedical Sciences.
Sources: Crossref, NC State University Libraries
Added: May 30, 2021
2014 journal article
Growth of Zircone on Nanoporous Alumina Using Molecular Layer Deposition
JOM, 66(4), 649–653.
Contributors: R. Hall*, S. George *, Y. Kim*, W. Hwang *, M. Samberg n, n , R. Narayan n
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
In vitro safety assessment of food ingredients in canine renal proximal tubule cells
Toxicology in Vitro, 29(2), 289–298.
Contributors: J. Koči *, B. Jeffery, J. Riviere* & *
author keywords: Food ingredients; Canine; Proximal tubule cells; Lemongrass oil; Gene expression; Metabolic pathway
MeSH headings : Acrolein / analogs & derivatives; Acrolein / toxicity; Aminophenols / toxicity; Animals; Cell Survival / drug effects; Citric Acid / toxicity; Dogs; Eugenol / toxicity; Food Safety; Gene Expression Profiling; Ginger; Guanosine Monophosphate / toxicity; Humans; Inosine Monophosphate / toxicity; Kidney Tubules, Proximal / cytology; Oils, Volatile / toxicity; Plant Extracts / toxicity; Plant Oils / toxicity; Plant Roots; Sorbose / toxicity; Terpenes / toxicity; Thymol / toxicity; Thymus Plant; Toxicity Tests / methods; Xylitol / toxicity
TL;DR:
Viability assays along with mechanistic studies in the CPTC model may serve as a valuable in vitro toxicity screening tool.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 3, 2021
2014 journal article
Nanoparticle Surface Characterization and Clustering through Concentration-Dependent Surface Adsorption Modeling
ACS Nano, 8(9), 9446–9456.
Contributors: R. Chen, Y. Zhang, F. Darabi Sahneh, C. Scoglio, W. Wohlleben *, A. Haase *, * , J. Riviere*
author keywords: BSAI; nanoparticles; nanomedicine; nanotoxicology surface physicochemistry; in situ characterization
MeSH headings : Adsorption; Models, Molecular; Nanoparticles / chemistry; Surface Properties
TL;DR:
The approach beyond the application of five descriptors in the original BSAI to address the concentration dependence of the descriptors, enabling better prediction of the adsorption profile and more accurate categorization of nanomaterials based on their surface properties is advanced.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: June 12, 2021
2014 book
Sources: Crossref, NC State University Libraries
Added: June 12, 2021
2014 journal article
Pharmacokinetics of metallic nanoparticles
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 7(2), 189–217.
Contributors: Z. Lin *, * & J. Riviere*
MeSH headings : Animals; Humans; Metal Nanoparticles / chemistry; Models, Biological; Pharmacokinetics
TL;DR:
Physiologically based pharmacokinetic models for gold/dendrimer composite nanodevices, AgNPs, and TiO2 NP models have been developed in rats and extrapolated to humans to support risk assessment and nanomedicine applications.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 30, 2021
2014 journal article
Predicting the impact of biocorona formation kinetics on interspecies extrapolations of nanoparticle biodistribution modeling
Nanomedicine, 10(1), 25–33.
Contributors: F. Sahneh *, C. Scoglio *, * & J. Riviere*
author keywords: allometry; biocorona; interspecies extrapolation; in vitro-in vivo correlation; nanomaterials; nanoparticle biodistribution
MeSH headings : Animals; Humans; Kinetics; Mice; Models, Theoretical; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Pharmacokinetics; Rats; Surface Properties; Tissue Distribution
TL;DR:
While engineered NPs can successfully reach target cells in rodent models, the results may be different in humans due to the fact that the longer circulation time allows for further biocorona evolution.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 30, 2021
2014 chapter
Safety Implications of Nanomaterial Exposure to Skin
In N. A. Monteiro-Riviere & C. L. Tran (Eds.), Nanotoxicology: Progress toward nanomedicine (2nd ed., pp. 267–292).
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: June 12, 2021
2014 chapter
Silver Nanoparticles in Biomedical Applications
In N. A. Monteiro-Riviere & C. Lang Tran (Eds.), Nanotoxicology: Progress toward Nanomedicine (2nd ed., pp. 425–442).
Sources: Crossref, NC State University Libraries
Added: June 12, 2021
2013 journal article
Computational approaches and metrics required for formulating biologically realistic nanomaterial pharmacokinetic models
Computational Science & Discovery, 6(1), 014005.
Contributors: J. Riviere *, C. Scoglio *, F. Sahneh * & *
Sources: Crossref, NC State University Libraries, ORCID
Added: June 12, 2021
2013 journal article
In Vitro Biocompatibility and Antibacterial Efficacy of a Degradable Poly(L-lactide-co-epsilon-caprolactone) Copolymer Incorporated with Silver Nanoparticles
ANNALS OF BIOMEDICAL ENGINEERING, 42(7), 1482–1493.
Contributors: M. Samberg n, P. Mente n, T. He n, M. King n & n
author keywords: Nanoparticle; Keratinocyte; Skin tissue engineering; Scaffold; Biocompatibility
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biodegradable Plastics / chemistry; Biodegradable Plastics / pharmacology; Cell Proliferation / drug effects; Epidermal Cells; Epidermis / metabolism; Humans; Keratinocytes / cytology; Keratinocytes / metabolism; Materials Testing; Metal Nanoparticles / chemistry; Polyesters / chemistry; Polyesters / pharmacology; Silver / chemistry; Silver / pharmacology; Tissue Engineering
TL;DR:
Findings suggest that a scaffold containing between 0.5 and 1.0 mg(Ag) g(scaffold)−1 is both biocompatible and antibacterial, and is suitable for skin tissue engineering graft scaffolds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 review
Nanomaterials and synergistic low-intensity direct current (LIDC) stimulation technology for orthopedic implantable medical devices
[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 5(3), 191–204.
Contributors: R. Shirwaiker n , M. Samberg n, P. Cohen n , R. Wysk n & n
MeSH headings : Animals; Electric Stimulation / methods; Equipment and Supplies; Humans; Nanostructures / therapeutic use; Nanostructures / ultrastructure; Nanotechnology / methods; Orthopedics; Prostheses and Implants
TL;DR:
While many nanomaterials have clearly demonstrated their ability to provide more effective implantable medical surfaces, further decisive investigations are necessary before they can translate into medically safe and commercially viable clinical applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 review
Predicting skin permeability from complex vehicles
[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 65(2), 265–277.
Contributors: D. Karadzovska n, J. Brooks n, n & J. Riviere n
author keywords: Chemical mixtures; Formulations; Percutaneous/dermal absorption; Quantitative structure-permeation relationship (QSPR); QSAR; Linear free energy relationships (LFER); Mixture factor; Topical drug delivery enhancers
MeSH headings : Animals; Drug Delivery Systems; Humans; Linear Energy Transfer; Models, Theoretical; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / metabolism; Pharmaceutical Vehicles / chemistry; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption
TL;DR:
This review highlights the progress made in predicting skin permeability from complex vehicles by extending the use of quantitative structure-permeation relationship (QSPR) models based on linear free energy relationships (LFER) to predict dermal absorption from complex mixtures with the inclusion of significant molecular descriptors such as a mixture factor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Protein binding modulates the cellular uptake of silver nanoparticles into human cells: Implications for in vitro to in vivo extrapolations?
TOXICOLOGY LETTERS, 220(3), 286–293.
Contributors: n , M. Samberg n, S. Oldenburg* & J. Riviere n
author keywords: Protein corona; Protein binding of nanoparticles; Cellular uptake of silver nanoparticles; Albumin cell uptake; Transferrin cell uptake; IgG cell uptake
MeSH headings : Humans; Immunoglobulin G / metabolism; Keratinocytes / metabolism; Metal Nanoparticles / chemistry; Microscopy, Electron, Transmission; Protein Binding; Serum Albumin / metabolism; Silver / metabolism; Transferrin / metabolism
TL;DR:
NP association with different serum proteins, purportedly forming different protein coronas, significantly modulates Ag uptake into HEK compared to native NP uptake, suggesting caution in extrapolating in vitro uptake data to predict behavior in vivo where the nature of the protein corona may determine patterns of cellular uptake, and thus biodistribution, biological activity and toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
The effects of geometry on skin penetration and failure of polymer microneedles
JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY, 27(3), 227–243.
Contributors: S. Gittard n, B. Chen n, H. Xu n, A. Ovsianikov *, B. Chichkov *, n , R. Narayan n
author keywords: microneedle; micromolding; acrylate-based polymer; porcine skin
TL;DR:
Video captured during skin penetration revealed that microneedle penetration into the skin occurred by means of a series of insertions and not by Means of a single insertion event, shedding insight into the mechanisms of microneEDle penetration and failure, facilitating design improvements for polymer microneeds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Acute vascular effects of nanoparticle infusion in isolated perfused skin
Nanomedicine: Nanotechnology, Biology and Medicine, 8(4), 428–431.
Contributors: J. Riviere n, T. Leavens n , J. Brooks n & n
author keywords: Nanoparticles; Vascular toxicity; In vitro; Biodistribution
MeSH headings : Animals; Female; Perfusion; Quantum Dots; Skin / blood supply; Skin / pathology; Skin / physiopathology; Sus scrofa; Vascular Resistance / drug effects
TL;DR:
Specific nanoparticle infusions were demonstrated to be associated with significant acute vascular physiological effects, and these observations suggest certain nanoparticles infusions may beassociated with acute vascular physiologic effects that merit further attention.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Biocompatibility analysis of an electrically-activated silver-based antibacterial surface system for medical device applications
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 24(3), 755–760.
Contributors: M. Samberg n, Z. Tan*, n , P. Orndorff n & R. Shirwaiker n
MeSH headings : Anti-Bacterial Agents; Biocompatible Materials; Equipment and Supplies; Escherichia coli / drug effects; Microbial Sensitivity Tests; Silver; Staphylococcus aureus / drug effects; Surface Properties
TL;DR:
The study concluded that the technological applications of the surface system for medical devices and surgical tools, which contact human tissues for less than 1.5 h, are expected to be self-sterilizing without causing toxicity in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Challenges obtaining a biowaiver for topical veterinary dosage forms
Journal of Veterinary Pharmacology and Therapeutics, 35(SUPPL. 1), 103–114.
Contributors: R. Baynes n , J. Riviere n, T. Franz, n , P. Lehman, M. Peyrou *, P. Toutain *
MeSH headings : Administration, Topical; Animals; Dosage Forms; Drug Administration Routes; Legislation, Drug; Species Specificity; Therapeutic Equivalency; Veterinary Drugs / administration & dosage; Veterinary Drugs / chemistry; Veterinary Drugs / pharmacokinetics
TL;DR:
The focus of this paper is to address several of the challenges associated with determining the BE of these locally acting drugs and critically examine the current technological advances that can act as a surrogate for clinical trials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2012 chapter
Effects of Engineered Nanomaterials on Skin
In B. Fadeel, A. Pietroiusti, & A. Shvedova (Eds.), Adverse Effects of Engineered Nanomaterials : Exposure, Toxicology, and Impact on Human Health (pp. 185–207). Burlington: Elsevier Science.
Ed(s): B. Fadeel, A. Pietroiusti & A. Shvedova
Source: NC State University Libraries
Added: June 12, 2021
2012 journal article
Effects of eight nanoparticles of different sizes and shapes on human epidermal keratinocytes
Journal of Investigative Dermatology, 132, S52. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000302866900308&KeyUID=WOS:000302866900308
Source: ORCID
Added: June 27, 2019
2012 chapter
In Vitro and In Vivo Toxicity of Silver Nanoparticles
In E. B. Bhushan) (Ed.), Encyclopedia of Nanotechnology (pp. 1069–1077,). Heidelberg, Germany: Springer Verlag.
Ed(s): E. Bhushan)
Source: NC State University Libraries
Added: June 12, 2021
2012 journal article
In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps
JOURNAL OF APPLIED TOXICOLOGY, 32(11), 913–919.
Contributors: T. Leavens n , n , A. Inman n, J. Brooks n, S. Oldenburg* & J. Riviere n
author keywords: silver nanoparticles; biodistribution; skin
MeSH headings : Animals; Metal Nanoparticles / chemistry; Nanoparticles / chemistry; Perfusion; Silver / chemistry; Silver / pharmacokinetics; Skin / metabolism; Swine / metabolism; Tissue Distribution
TL;DR:
The objective of the present study was to quantify the local biodistribution of two types of Ag nanoparticles, Ag‐citrate and Ag‐silica, in the isolated perfused porcine skin flap (IPPSF), and found no detectable elimination of Ag from the system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
LACK OF HYDROXYLATED FULLERENE TOXICITY AFTER INTRAVENOUS ADMINISTRATION TO FEMALE SPRAGUE-DAWLEY RATS
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 75(7), 367–373.
Contributors: n , K. Linder n, A. Inman n, J. Saathoff n, X. Xia n & J. Riviere n
MeSH headings : Animals; Blood Chemical Analysis; Drug Administration Schedule; Female; Fullerenes / administration & dosage; Fullerenes / chemistry; Fullerenes / toxicity; Injections, Intravenous; Liver / drug effects; Lymphocytes / drug effects; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / toxicity; Rats; Rats, Sprague-Dawley; Thymus Gland / drug effects; Toxicity Tests, Acute; Urinalysis
TL;DR:
These experiments suggest that this fullerol was well tolerated after iv administration to rats, and no clinically significant chemistry changes were observed after treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Oxidative Stress and Dermal Toxicity of Iron Oxide Nanoparticles In Vitro
CELL BIOCHEMISTRY AND BIOPHYSICS, 67(2), 461–476.
Contributors: A. Murray*, E. Kisin*, A. Inman n, S. Young*, M. Muhammed *, T. Burks*, A. Uheida*, A. Tkach*
author keywords: Nanoparticles; Skin exposure; Ultraviolet radiation; Iron oxide
MeSH headings : Biological Transport; Cell Survival / drug effects; Cytokines / metabolism; Glutathione / metabolism; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; L-Lactate Dehydrogenase / metabolism; Magnetite Nanoparticles / chemistry; Magnetite Nanoparticles / toxicity; NF-kappa B / metabolism; Oxidative Stress / drug effects; Particle Size; Skin / cytology; Skin / drug effects; Transcription Factor AP-1 / metabolism
TL;DR:
Data indicate that co-exposure to UVB and SPIONs was associated with induction of oxidative stress and release of inflammatory mediators, verifying the need to thoroughly evaluate the adverse effects of UVB when evaluating dermal toxicity of engineered NPs on skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Silver nanoparticles do not influence stem cell differentiation but cause minimal toxicity
NANOMEDICINE, 7(8), 1197–1209.
Contributors: M. Samberg n, E. Loboa n, S. Oldenburg* & n
author keywords: in vitro; nanoparticles; nanotechnology; nanotoxicology; scaffolds; silver; stem cells
MeSH headings : Adipose Tissue / cytology; Adult; Cell Differentiation / drug effects; Cell Survival / drug effects; Cells, Cultured; Female; Humans; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Silver / toxicity; Stem Cells / cytology; Stem Cells / drug effects; Young Adult
TL;DR:
The biocompatibility of Ag-NPs with both undifferentiated and differentiated hASC establishes their suitability for incorporation into tissue-engineered graft scaffolds, for the prevention of bacterial contamination upon implantation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 chapter
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 25, 2022
2012 chapter
Skin Penetration of Engineered Nanomaterials
In E. A. Nasir, A. Friedman, & S. Wang (Eds.), Nanotechnology in Dermatology (Vol. 9781461450344, pp. 51–61).
Ed(s): E. Nasir, A. Friedman & S. Wang
TL;DR:
This chapter is to depict how skin can serve as a potential route of exposure to several types of nanomaterials, and will discuss how size, shape, charge, surface properties, and vehicles can be important determinants on the penetration through the rate-limiting lipid barrier of the stratum corneum.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: June 12, 2021
2012 journal article
Two-photon polymerization/micromolding of microscale barbs for medical applications
Journal of Adhesion Science and Technology, 28(3-4), 387–398.
Contributors: R. Boehm n, B. Chen n, S. Gittard, B. Chichkov n, n , A. Nasir*, R. Narayan n
author keywords: tissue barb; wound sealant; two-photon polymerization; micromolding; indirect rapid prototyping
TL;DR:
The results suggest that two-photon polymerization/micromolding is an indirect rapid prototyping approach that may be used for high-throughput replication of tissue barbs and other microstructured solid wound sealants.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2012 journal article
Ultrananocrystalline Diamond-Coated Microporous Silicon Nitride Membranes for Medical Implant Applications
JOM, 64(4), 520–525.
Contributors: S. Skoog n, A. Sumant *, n & R. Narayan n
TL;DR:
The results show that the UNCD coating did not significantly alter the viability of human epidermal keratinocytes, indicating potential use of this material for improving skin sealing around percutaneous implants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Use of confocal microscopy for nanoparticle drug delivery through skin
Journal of Biomedical Optics, 18(6), 061214.
Contributors: L. Zhang * & *
author keywords: nanoparticles; confocal laser scanning microscopy; skin; keratinocytes
MeSH headings : Animals; Cell Line; Dendritic Cells / chemistry; Dendritic Cells / metabolism; Hair Follicle / chemistry; Hair Follicle / metabolism; Humans; Keratinocytes / chemistry; Keratinocytes / metabolism; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Microscopy, Confocal / methods; Quantum Dots; Silver / chemistry; Skin / chemistry; Skin / cytology; Skin / metabolism; Skin Absorption / drug effects; Skin Absorption / physiology; Swine
TL;DR:
The unique functions of CLSM such as the ability to detect fluorescence, optical sectioning, three dimensional remodeling, as well as its use in the reflection mode in tandem with other methods, provides great promise with broad applications regarding the interactions of nanomaterials with skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: May 30, 2021
2012 journal article
Zinc oxide - nanosize does not change the toxicological profile
Naunyn-Schmiedebergs Archives of Pharmacology, 385, 104. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000300779500460&KeyUID=WOS:000300779500460
Source: ORCID
Added: June 27, 2019
2011 journal article
Atomic layer deposition of titanium dioxide on cellulose acetate for enhanced hemostasis
Biotechnology Journal, 6(2), 213–223.
Contributors: G. Hyde n, S. Stewart n, G. Scarel n, G. Parsons n , C. Shih *, C. Shih*, S. Lin*, Y. Su*, n , R. Narayan n
author keywords: Biomaterials; Cellulose; Hemocompatibility; Hemostatic agent; Titanium oxide
MeSH headings : Cell Survival / physiology; Cellulose / analogs & derivatives; Cellulose / chemistry; Cellulose / pharmacology; Hemostasis / drug effects; Humans; Microscopy, Electron, Scanning; Platelet-Rich Plasma / drug effects; Spectroscopy, Fourier Transform Infrared; Titanium / chemistry; Wettability
TL;DR:
The results suggest that atomic layer deposition is an appropriate method for improving the biological properties of hemostatic agents and other blood-contacting biomaterials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Cellular uptake mechanisms and toxicity of quantum dots in dendritic cells
NANOMEDICINE, 6(5), 777–791.
Contributors: L. Zhang n, W. Baeumer & *
author keywords: cellular uptake; dendritic cells; endocytosis; LPS; nanoparticles; quantum dot nanoparticles; scavenger receptor
MeSH headings : Animals; B7-1 Antigen / immunology; B7-2 Antigen / immunology; Cell Differentiation; Cell Survival; Cells, Cultured; Dendritic Cells / cytology; Dendritic Cells / immunology; Endocytosis; Granulocyte-Macrophage Colony-Stimulating Factor / immunology; Lipopolysaccharides / immunology; Monocytes / cytology; Monocytes / immunology; Quantum Dots; Swine
TL;DR:
Light is shed on the mechanism of QD655-COOH uptake in DCs and that cellular uptake pathways are dependent on cell type and cell differentiation, suggesting suppression with DC maturation.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 article
Commentary on transcutaneous delivery
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, Vol. 3, pp. 439–440.
TL;DR:
The article by Bolzinger, Briançon, and Chevalier in this issue of WIREs Nanomedicine and Nanobiotechnology focuses on addressing the apparent discrepancies in skin penetration of inorganic and organic nanoparticles used in cosmetics and pharmaceutical applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Deposition of antimicrobial coatings on microstereolithography-fabricated microneedles
JOM, 63(6), 59–68.
Contributors: S. Gittard n, P. Miller n, C. Jin n, T. Martin n, R. Boehm n, B. Chisholm *, S. Stafslien*, J. Daniels*
TL;DR:
It is indicated that light-based technologies, including visible light dynamic mask microstereolithography and pulsed laser deposition, may be used to fabricate microneedles with antimicrobial properties for treatment of local skin infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Dermal Penetration of UVB-Damaged Skin by Titanium- and Zincoxide Nanoparticles in Sunscreen Formulations
Naunyn-Schmiedebergs Archives of Pharmacology, 383, 101. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000288573100511&KeyUID=WOS:000288573100511
Source: ORCID
Added: June 27, 2019
2011 journal article
In vitro toxicity assessment of three hydroxylated fullerenes in human skin cells
TOXICOLOGY IN VITRO, 25(8), 2105–2112.
Contributors: J. Saathoff n, A. Inman n, X. Xia n, J. Riviere n & n
author keywords: Hydroxylated fullerenes; Fullerenes; Cytotoxicity; Skin cells; Keratinocytes; Nanoparticles
MeSH headings : Biological Transport; Cell Survival; Cells, Cultured; Fullerenes / chemistry; Fullerenes / metabolism; Fullerenes / toxicity; Humans; Hydroxylation; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / ultrastructure; Microscopy, Electron, Transmission; Photoelectron Spectroscopy; Spectrometry, Fluorescence
TL;DR:
Results suggest that different hydroxylation of fullerenes caused no cytotoxicity or inflammation up to 8.55 μg/ml, and suggest that extrapolation across similar NP will be dependent upon surface chemistry and concentration which may affect the degree of agglomeration and thus biological effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing
Biomicrofluidics, 5(1), 013415.
Contributors: P. Miller n, S. Gittard n, T. Edwards*, D. Lopez*, X. Xiao*, D. Wheeler*, n , S. Brozik*, R. Polsky*, R. Narayan n
TL;DR:
Carbon fiber electrodes were incorporated within a hollow microneedle array, which was fabricated using a digital micromirror device-based stereolithography instrument, and electrochemical measurements were demonstrated using integrated electrode-hollow micronedle devices.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, Crossref
Added: August 6, 2018
2011 journal article
Mapping the Surface Adsorption Forces of Nanomaterials in Biological Systems
ACS NANO, 5(11), 9074–9081.
Contributors: X. Xia n, n , S. Mathur *, X. Song *, L. Xiao*, S. Oldenberg*, B. Fadeel *, J. Riviere n
author keywords: engineered nanomaterials; surface adsorption; risk assessment; nanotoxicology; nanomedicine; nanomaterial characterization
MeSH headings : Adsorption; Biology; Nanostructures / chemistry; Surface Properties
TL;DR:
The BSAI nanodescriptors are intrinsic properties of nanomaterials useful for quantitative structure-activity relationship (QSAR) model development and could open a quantitative avenue in predictive nanomedicine development, risk assessment, and safety evaluation of nanmaterials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Modification of microneedles using inkjet printing
AIP Advances, 1(2), 022139.
Contributors: R. Boehm n, P. Miller n, S. Hayes n, n & R. Narayan n
TL;DR:
The results suggest that the combination of visible light dynamic mask micro-stereolithography-micromolding and inkjet printing enables fabrication of solid biodegradable microneedles with a widerange of geometries as well as a wide range of pharmacologic agent compositions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Quantum dot penetration into viable human skin
NANOTOXICOLOGY, 6(2), 173–185.
Contributors: T. Prow *, n , A. Inman n, J. Grice *, X. Chen *, X. Zhao *, W. Sanchez*, A. Gierden*
author keywords: Nanoparticles; exposure; nanotoxicology; surface chemistry
MeSH headings : Diffusion Chambers, Culture; Female; Humans; Hydrogen-Ion Concentration; Microscopy, Confocal; Nanoparticles; Particle Size; Polyethylene Glycols / metabolism; Polyethylene Glycols / pharmacology; Quantum Dots; Skin / chemistry; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Tissue Culture Techniques
TL;DR:
Systematic studies probing the effects of nanoparticle surface modification and formulation pH are important in nanotoxicology and nanomedicine and this study uses laser-scanning fluorescence confocal microscopy to evaluate nanoparticle penetration in viable excised human skin that was intact or tape-stripped.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Safety Evaluation of Sunscreen Formulations Containing Titanium Dioxide and Zinc Oxide Nanoparticles in UVB Sunburned Skin: An In Vitro and In Vivo Study
TOXICOLOGICAL SCIENCES, 123(1), 264–280.
Contributors: n , K. Wiench *, R. Landsiedel *, S. Schulte *, A. Inman n & J. Riviere n
author keywords: sunscreens; sunburn skin; titanium dioxide (TiO2); zinc oxide (ZnO); nanoparticles; skin penetration
MeSH headings : Animals; Erythema / etiology; Erythema / pathology; Erythema / prevention & control; In Vitro Techniques; Metal Nanoparticles / radiation effects; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Particle Size; Skin / drug effects; Skin / pathology; Skin / radiation effects; Skin / ultrastructure; Sunburn / drug therapy; Sunburn / etiology; Sunburn / pathology; Sunscreening Agents / pharmacokinetics; Sunscreening Agents / toxicity; Swine / physiology; Titanium / pharmacokinetics; Titanium / radiation effects; Titanium / toxicity; Ultraviolet Rays / adverse effects; Zinc Oxide / pharmacokinetics; Zinc Oxide / radiation effects; Zinc Oxide / toxicity
TL;DR:
UVB-damaged skin slightly enhanced TiO(2) NP or ZnO NP penetration in sunscreen formulations but no transdermal absorption was detected.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 chapter
Absorption, Penetration, and Cutaneous Toxicity of Jet Fuels and Hydrocarbon Components
In Jet Fuel Toxicology (pp. 119–134).
Sources: Crossref, NC State University Libraries
Added: June 12, 2021
2010 chapter
Absorption, penetration, and cutaneous toxicity of jet fuels and hydrocarbon components
In Jet Fuel Toxicology (pp. 119–134).
Source: ORCID
Added: September 25, 2022
2010 journal article
An index for characterization of nanomaterials in biological systems
Nature Nanotechnology, 5(9), 671–675.
Contributors: X. Xia n, n & J. Riviere n
MeSH headings : Adsorption; Hormones / chemistry; Models, Chemical; Nanostructures / chemistry; Nanotubes, Carbon / chemistry; Proteins / chemistry; Small Molecule Libraries / chemistry; Steroids / chemistry
TL;DR:
The method successfully predicted the adsorption of various small molecules onto carbon nanotubes, and the nanodescriptors can be used to develop pharmacokinetic and safety assessment models for nanomaterials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2010 journal article
Antibacterial efficacy of silver nanoparticles of different sizes, surface conditions and synthesis methods
NANOTOXICOLOGY, 5(2), 244–253.
Contributors: M. Samberg n, P. Orndorff n & *
author keywords: Silver; nanoparticles; nanotechnology; nanotoxicity; microbiology
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Escherichia coli / drug effects; Humans; Materials Testing; Metal Nanoparticles / chemistry; Metal Nanoparticles / ultrastructure; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Particle Size; Silver / chemistry; Silver / pharmacology; Staphylococcus aureus / drug effects; Surface Properties
TL;DR:
Silver nanoparticles are used as a natural biocide to prevent undesired bacterial growth in clothing and cosmetics to assess the antibacterial efficacy of Ag-nps of different sizes, surface conditions, and synthesis methods against Escherichia coli, Ag-resistant E. coli, methicillin-resistant S. aureus, and Salmonella sp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Atomic layer deposition of nanoporous biomaterials
MATERIALS TODAY, 13(3), 60–64.
Contributors: R. Narayan n, S. Adiga*, M. Pellin *, L. Curtiss *, S. Stafslien*, B. Chisholm *, n , R. Brigmon *, J. Elam *
TL;DR:
The results suggest that atomic layer deposition is an attractive technique for modifying the surfaces of nanoporous alumina membranes and other nanostructured biomaterials.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Atomic layer deposition-based functionalization of materials for medical and environmental health applications
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 368(1917), 2033–2064.
Contributors: R. Narayan n, S. Adiga*, M. Pellin *, L. Curtiss *, A. Hryn *, S. Stafslien*, B. Chisholm *, C. Shih*
author keywords: atomic layer deposition; self-assembly; nanoporous alumina; antimicrobial; antifouling
MeSH headings : Adsorption; Aluminum Oxide / chemistry; Anti-Bacterial Agents / chemistry; Blood Platelets / metabolism; Coated Materials, Biocompatible / chemistry; Equipment Design; Escherichia coli / metabolism; Humans; Materials Testing; Nanostructures / chemistry; Nanotechnology / methods; Platinum / chemistry; Polyethylene Glycols / chemistry; Staphylococcus aureus / metabolism; Zinc Oxide / chemistry
TL;DR:
The results of this work indicate that nanoporous alumina membranes may be modified using atomic layer deposition for use in a variety of medical and environmental health applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
CYTOKINE AND CHEMOKINE LEVELS IN SERUM AND CEREBROSPINAL FLUID OF DOGS WITH INFLAMMATORY CENTRAL NERVOUS SYSTEM DISEASE
Journal of Veterinary Internal Medicine, 24(3), 741. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000277416600262&KeyUID=WOS:000277416600262
Contributors: C. Mariani, L. Boozer, G. Cherubini, K. Vernau, J. Campbell, S. Dillard, P. Early, R. Gallagher
Source: ORCID
Added: June 27, 2019
2010 chapter
Characterization of Toxicoproteomics Maps for Chemical Mixtures Using Information Theoretic Approach
In Principles and Practice of Mixtures Toxicology (pp. 215–234).
Contributors: S. Basak *, B. Gute*, n & F. Witzmann *
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 30, 2021
2010 chapter
Dermal Exposure and Absorption of Chemicals and Nanomaterials*
In Comprehensive Toxicology (Vol. 1-14, pp. 111–122).
Contributors: J. Riviere n & n
TL;DR:
Techniques for quantitating skin permeability using this assumption and basic approaches to linking permeability to molecular properties using quantitative structure permeability relationships (QSPeR) are presented.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 30, 2021
2010 journal article
EVALUATION OF CYTOKINE AND CHEMOKINE LEVELS IN CANINE INTRACRANIAL NEOPLASIA
Journal of Veterinary Internal Medicine, 24(3), 741. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000277416600264&KeyUID=WOS:000277416600264
Contributors: L. Boozer, C. Mariani, J. Campbell, S. Dillard, P. Early, R. Gallagher, E. MacKillop, K. Munana
Source: ORCID
Added: June 27, 2019
2010 chapter
Evaluating the risks associated with nanomaterials
In E. A. V. Narlikar & Y. Y. Du (Eds.), The Oxford Handbook of Nanoscience and Technology, Frontiers and Advances: Vol. III (pp. 888–906,). Oxford: Oxford University Press.
Ed(s): E. Narlikar & Y. Du
Source: NC State University Libraries
Added: June 12, 2021
2010 journal article
Evaluation of Silver Nanoparticle Toxicity in Skin in Vivo and Keratinocytes in Vitro
ENVIRONMENTAL HEALTH PERSPECTIVES, 118(3), 407–413.
Contributors: M. Samberg n, S. Oldenburg* & n
author keywords: keratinocytes; metal oxides; nanoparticles; nanotechnology; porcine skin; silver; skin penetration; toxicity
MeSH headings : Animals; Cell Survival / drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Humans; Inflammation / chemically induced; Inflammation / metabolism; Inflammation / pathology; Interleukins / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / toxicity; Particle Size; Silver / administration & dosage; Silver / toxicity; Skin / cytology; Skin / drug effects; Skin / metabolism; Swine; Time Factors; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
A better understanding of Ag-nps safety in vitro as well as in vivo is provided and a basis for occupational and risk assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles
TOXICOLOGY LETTERS, 197(1), 1–6.
Contributors: T. Leavens n , X. Xia n, H. Lee n, n , J. Brooks n & J. Riviere n
author keywords: nC(60); Isolated perfused porcine skin flaps; Pharmacokinetics; In vitro; Nanoparticles; Skin
MeSH headings : Animals; Arteries / metabolism; Colloids; Female; Fullerenes / pharmacokinetics; Immunoglobulin G / metabolism; Models, Animal; Nanoparticles / ultrastructure; Skin / metabolism; Swine; Tissue Distribution; Veins / metabolism
TL;DR:
Based on the apparent volume of distribution, the low extraction during the perfusion, and the high percentage recovery following the washout phase, there was limited distribution of fullerene nanoparticles from the vascular space into the extracellular space and negligible intracellular uptake of nC(60) in this system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Fabrication of Microneedles Using Two Photon Polymerization for Transdermal Delivery of Nanomaterials
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 10(10), 6305–6312.
Contributors: A. Doraiswamy n, A. Ovsianikov, S. Gittard*, * , R. Crombez, E. Montalvo, W. Shen, B. Chichkov, R. Narayan*
author keywords: Microneedle; Transdermal Drug Delivery; Rapid Prototyping; Nanomaterials; Human Epidermal Keratinocytes
MeSH headings : Administration, Cutaneous; Animals; Biocompatible Materials / administration & dosage; Biocompatible Materials / chemistry; Cell Survival / drug effects; Cells, Cultured; Drug Delivery Systems / instrumentation; Elastic Modulus; Equipment Design; Female; Hardness; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Materials Testing; Microscopy, Confocal; Microscopy, Electron, Scanning; Microtechnology / methods; Nanostructures / administration & dosage; Needles; Polymerization; Quantum Dots; Skin / drug effects; Skin / metabolism; Swine
TL;DR:
Microneedies were shown to enable more rapid distribution of the PEG-amine quantum dot solution to the deep epidermis and dermis layers of porcine skin than topical administration and suggest that two photon polymerization may be used to create microneedle arrays for transdermal delivery of nanoscale pharmacologic agents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
In vitro biocompatibility of titanium alloy discs made using direct metal fabrication
MEDICAL ENGINEERING & PHYSICS, 32(6), 645–652.
Contributors: C. Haslauer n, J. Springer n, O. Harrysson n , E. Loboa n, n & D. Marcellin-Little n
author keywords: Biocompatibility; Orthopedic implant; Free-form fabrication; Direct metal fabrication; Electron beam melting; Stem cell; Human stem cell
MeSH headings : Adipose Tissue / cytology; Alloys / chemical synthesis; Alloys / chemistry; Alloys / pharmacology; Aluminum / chemistry; Cell Proliferation / drug effects; Cell Survival / drug effects; Female; Humans; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Materials Testing / methods; Middle Aged; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / metabolism; Surface Properties; Titanium / chemistry; Titanium / pharmacology; Vanadium / chemistry
TL;DR:
In vitro biocompatibility of EBM titanium-6 aluminum-4 vanadium (Ti6Al4V) structures is assessed by comparing the cellular response to solid polished, solid unpolished, and porous EBM discs to the Cellular response to discs made of commercially produced Ti6Al 4V.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Intrinsic biological property of colloidal fullerene nanoparticles (nC(60)): Lack of lethality after high dose exposure to human epidermal and bacterial cells
TOXICOLOGY LETTERS, 197(2), 128–134.
Contributors: X. Xia n, n & J. Riviere n
author keywords: Water-soluble fullerenes; Nanotoxicity; Fullerene nanoparticles; Bacteria toxicity; Human epidermal keratinocytes
MeSH headings : Bacillus subtilis / drug effects; Epidermal Cells; Escherichia coli / drug effects; Fullerenes / chemistry; Fullerenes / toxicity; Humans; Keratinocytes / drug effects; Microbial Sensitivity Tests; Nanoparticles / chemistry; Nanoparticles / toxicity; Particle Size; Toxicity Tests
TL;DR:
A novel method for preparing nC60 nanoparticles that does not use THF solvent, but provides nC 60 with an average particle size of 43.8 nm and a yield approximately 100 times higher than the THF method is reported, confirming the prior non-toxic reports when using nC50 prepared with non-THF methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles
FARADAY DISCUSSIONS, 149, 171–185.
Contributors: S. Gittard n, P. Miller n, R. Boehm n, A. Ovsianikov *, B. Chichkov *, J. Heiser*, J. Gordon *, n , R. Narayan n
MeSH headings : Administration, Cutaneous; Animals; Drug Delivery Systems / instrumentation; Female; Humans; Infant, Newborn; Keratinocytes / chemistry; Microinjections / methods; Microscopy, Fluorescence; Needles; Polymers / chemistry; Quantum Dots; Skin / chemistry; Skin / cytology; Swine
TL;DR:
In this study, microneedle devices for transdermal drug delivery were fabricated by means of two-photon polymerization of an acrylate-based polymer to examine proliferation of cells on this polymer using neonatal human epidermal keratinocytes and human dermal fibroblasts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 chapter
Nanomaterial penetration
In Toxicology of the Skin (pp. 333–346). http://www.scopus.com/inward/record.url?eid=2-s2.0-77958477177&partnerID=MN8TOARS
Source: ORCID
Added: September 25, 2022
2010 chapter
Potential Arsenic Exposure Through Dermal Penetration
In N. A. Monteiro-Riviere) (Ed.), Toxicology of the Skin (pp. 347–360). http://www.scopus.com/inward/record.url?eid=2-s2.0-85056392662&partnerID=MN8TOARS
Ed(s): N. Monteiro-Riviere)
Sources: NC State University Libraries, ORCID
Added: June 12, 2021
2010 book
Preface
In Toxicology of the Skin (p. v). http://www.scopus.com/inward/record.url?eid=2-s2.0-85060190964&partnerID=MN8TOARS
Source: ORCID
Added: September 25, 2022
2010 chapter
Structure and Function of Skin
In N. A. Monteiro-Riviere (Ed.), Toxicology of the Skin (pp. 1–18,). http://www.scopus.com/inward/record.url?eid=2-s2.0-85056380325&partnerID=MN8TOARS
Sources: NC State University Libraries, ORCID
Added: June 12, 2021
2010 book
Toxicology of the skin
In Toxicology of the Skin (pp. 1–437). http://www.scopus.com/inward/record.url?eid=2-s2.0-84868687035&partnerID=MN8TOARS
Source: ORCID
Added: September 25, 2022
2010 journal article
Two Photon Polymerization-Micromolding of Polyethylene Glycol-Gentamicin Sulfate Microneedles
ADVANCED ENGINEERING MATERIALS, 12(4), B77–B82.
Contributors: S. Gittard n, A. Ovsianikov *, H. Akar*, B. Chichkov *, n , S. Stafslien*, B. Chisholm *, C. Shin*
TL;DR:
In this study, a photopolymerization‐micromolding technique was used to fabricate microneedle arrays from a photosensitive material containing polyethylene glycol 600 diacrylate, gentamicin sulfate, and a photoinitiator that inhibited growth of Staphylococcus aureus bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
ASSESSMENT OF QUANTUM DOT PENETRATION INTO SKIN IN DIFFERENT SPECIES UNDER DIFFERENT MECHANICAL ACTIONS
Nanomaterials: Risks and Benefits, 43–52.
TL;DR:
Results indicate that porcine skin penetration of QD621 is minimal and limited primarily to the outer SC layers, while QD565 and 655 penetrated into the dermis of abraded skin and skin is an important organ and can serve as a potential route of exposure and should be overlooked.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: June 27, 2019
2009 journal article
Assessing the antimicrobial activity of zinc oxide thin films using disk diffusion and biofilm reactor
APPLIED SURFACE SCIENCE, 255(11), 5806–5811.
Contributors: S. Gittard n, J. Perfect *, n , W. Wei n, C. Jin n & R. Narayan n
author keywords: Antimicrobial materials; Pulsed laser deposition; Zinc oxide
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Atomic layer deposition of TiO2 thin films on nanoporous alumina templates: Medical applications
JOM, 61(6), 12–16.
Contributors: R. Narayan n, n , R. Brigmon *, M. Pellin * & J. Elam *
TL;DR:
Atomic layer deposition was used to coat all the surfaces of a nanoporous alumina membrane in order to reduce the pore size in a controlled manner, and neither the 20 nm nor the 100 nm TiO2-coated nanoporus alumina membranes exhibited statistically lower viability compared to the uncoated nano-structure-based membrane control materials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Comparison of Quantum Dot Biodistribution with a Blood-Flow-Limited Physiologically Based Pharmacokinetic Model
Nano Letters, 9(2), 794–799.
Contributors: H. Lee n, T. Leavens n, S. Mason n, n & J. Riviere n
MeSH headings : Animals; Hemodynamics; Mice; Models, Biological; Organ Specificity; Pharmacokinetics; Quantum Dots; Rats; Tissue Distribution
TL;DR:
The physiologically based pharmacokinetic model predicted the experimentally observed persistence of QDs in tissues but not early time profiles or different QD biodistribution, suggesting more complex models will be needed to better predict QD biodiversity in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Comparison of quantum dot biodistribution with a blood-flow-limited physiologically based pharmacokinetic model
Nano Letters, 9(2), 794–799.
Source: ORCID
Added: September 25, 2022
2009 entry reference
Cutaneous Toxicology
Sources: Crossref, NC State University Libraries
Added: May 30, 2021
2009 journal article
Endocytic mechanisms and toxicity of a functionalized fullerene in human cells
TOXICOLOGY LETTERS, 191(2-3), 149–157.
Contributors: L. Zhang n, J. Yang *, A. Barron * & n
author keywords: Derivatized fullerene; Endocytosis; Cytotoxicity; Human epidermal keratinocytes; Cellular uptake; Nanoparticle
MeSH headings : Adenosine Triphosphate / metabolism; Cell Line; Cell Proliferation / drug effects; Cell Survival / drug effects; Coloring Agents; Drug Delivery Systems; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Fullerenes / chemistry; Fullerenes / toxicity; Humans; Lysosomes / drug effects; Microscopy, Confocal; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Models, Molecular; Spectrophotometry, Ultraviolet; Tetrazolium Salts; Thiazoles
TL;DR:
Results showed that the endocytic pathways could be mediated by caveolae/lipid rafts and cytoskeletal components and a scavenger receptor inhibitor completely blocked the uptake of Baa-Lys(FITC)-(Lys)(8)-OH, suggesting a specific endocytics pathway was strongly involved in Baa(F ITC)- (Lys)8-OH cellular uptake.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Fabrication of Polymer Microneedles Using a Two-Photon Polymerization and Micromolding Process
Journal of Diabetes Science and Technology, 3(2), 304–311.
Contributors: S. Gittard n, A. Ovsianikov *, n , J. Lusk*, P. Morel *, P. Minghetti *, C. Lenardi *, B. Chichkov *, R. Narayan n
MeSH headings : Administration, Cutaneous; Biocompatible Materials; Diabetes Mellitus / drug therapy; Dimethylpolysiloxanes / chemistry; Drug Delivery Systems / instrumentation; Humans; Insulin / administration & dosage; Microtechnology / methods; Needles; Polymethacrylic Acids / chemical synthesis
TL;DR:
The results suggest that a 2PP microfabrication and subsequent PDMS micromolding process may be used to create microneedle structures with appropriate structural, mechanical, and biological properties for transdermal drug delivery of insulin and other protein-based pharmacologic agents for treatment of diabetes mellitus.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 30, 2021
2009 chapter book
Human Health Risks of Engineered Nanomaterials
Contributors: A. Elder *, I. Lynch *, K. Grieger* , S. Chan-Remillard*, A. Gatti *, H. Gnewuch*, E. Kenawy *, R. Korenstein *
TL;DR:
This Working Group report summarizes the discussions of an expert scientific panel regarding the gaps in knowledge that impede effective human health risk assessment for nanomaterials, particularly those that are suspended in a gas or liquid and, thus, deposit on skin or in the respiratory tract.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: June 27, 2019
2009 chapter
Human health risks of engineered nanomaterials
In Nanomaterials: Risks and benefits (pp. 1–28). Dordrecht, Holland: Springer.
Ed(s): I. Linkov & J. Steevens
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Interaction of nanomaterials with skin: Aspects of absorption and biodistribution
Nanotoxicology, 3(3), 188–193.
Contributors: n & J. Riviere n
author keywords: Absorption; biodistribution; nanomaterials; penetration; skin; drug delivery; cosmetics; exposure; nanomedicine
TL;DR:
Research is beginning to be conducted to define the mechanistic framework describing nanomaterials biodistribution using pharmacokinetic models, suggesting that absorption is minimal, yet particle characteristics and species differences exist.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Interactions of aluminum nanoparticles with human epidermal keratinocytes
JOURNAL OF APPLIED TOXICOLOGY, 30(3), 276–285.
Contributors: n , S. Oldenburg* & A. Inman n
author keywords: aluminum; nanoparticles; human epidermal keratinocytes; nanotoxicity; viability assays; cytokine
MeSH headings : Aluminum / analysis; Aluminum / chemistry; Aluminum / toxicity; Artifacts; Cell Survival / drug effects; Cells, Cultured; Humans; Indicators and Reagents / chemistry; Inflammation Mediators / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / ultrastructure; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Microscopy, Electron, Transmission; Osmolar Concentration; Particle Size; Reproducibility of Results; Spectrophotometry; Temperature; Vacuoles / ultrastructure
TL;DR:
The difficulties involved in assessing the biological safety of nanomaterials such as Al NP due to media‐ and temperature‐dependent particle agglomeration and nanoparticle interactions with biomarkers of cytotoxicity are illustrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Lectins modulate multi-walled carbon nanotubes cellular uptake in human epidermal keratinocytes
TOXICOLOGY IN VITRO, 24(2), 546–551.
Contributors: L. Zhang n & n
author keywords: Nanomaterials; Multi-walled carbon nanotubes; Lectins; Endocytic pathways; Melanosome transfer pathway; Cellular uptake
MeSH headings : Epidermal Cells; Humans; Keratinocytes / drug effects; Keratinocytes / metabolism; Lotus / chemistry; Solanum lycopersicum / chemistry; Microscopy, Electron, Transmission; Nanotubes, Carbon / ultrastructure; Peas / chemistry; Plant Lectins / pharmacology
TL;DR:
Lectins are inhibitors of the melanosome transfer pathway was used to study the uptake of MWCNT in keratinocytes, to see if they played a role in reducing the cellular uptake of carbon nanotubes in HEK, and studies confirmed that lectin cocktails decreased M WCNT interaction at the cell surface and uptake.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 article
Mechanisms of Quantum Dot Nanoparticle Cellular Uptake
Zhang, L. W., & Monteiro-Riviere, N. A. (2009, July). TOXICOLOGICAL SCIENCES, Vol. 110, pp. 138–155.
Contributors: L. Zhang n & n
author keywords: quantum dot nanoparticles; endocytosis; lipid rafts; G-protein-coupled receptor; scavenger receptor; cytotoxicity
MeSH headings : Actins / metabolism; Cell Membrane / metabolism; Cell Membrane / ultrastructure; Cells / drug effects; Cells / metabolism; Cytoplasm / metabolism; Cytoplasm / ultrastructure; Cytoskeleton / drug effects; Endosomes / drug effects; Flow Cytometry; Free Radical Scavengers / pharmacology; Humans; Immunohistochemistry; Indicators and Reagents; Keratinocytes / drug effects; Lysosomes / metabolism; Lysosomes / ultrastructure; Membrane Microdomains / drug effects; Membrane Potentials / drug effects; Microscopy, Confocal; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Pinocytosis / drug effects; Quantum Dots; Spectrometry, Fluorescence; Transport Vesicles / drug effects; Transport Vesicles / metabolism
TL;DR:
It is shown that QD with a carboxylic acid surface coating were recognized by lipid rafts but not by clathrin or caveolae in human epidermal keratinocytes (HEKs) and endocytic pathways are primarily regulated by the G-protein-coupled receptor associated pathway and low density lipoprotein receptor/scavenger receptor.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Microfabricated curtains for controlled cell seeding in high throughput microfluidic systems
LAB ON A CHIP, 9(12), 1756–1762.
Contributors: . Adrian T. O'Neill*, n & G. Walker*
MeSH headings : Cell Culture Techniques / instrumentation; Cell Movement; Cell Proliferation; Cell Survival / drug effects; Collagen / metabolism; Cytotoxins / toxicity; Dimethylpolysiloxanes; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Microfluidic Analytical Techniques / instrumentation; Nylons; Skin / cytology; Time Factors
TL;DR:
Curtain use permitted high initial cell seeding densities and increased the amount of time cells can be cultured compared to multi-well plates and showed that cells exposed to 6% ethanol or less grew in population size, 8% ethanol exposure stunted growth, and higher concentrations led to population loss.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Nanoporous membranes for medical and biological applications
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 1(5), 568–581.
Contributors: S. Adiga *, C. Jin*, L. Curtiss *, n & R. Narayan*
MeSH headings : Biomedical Technology / methods; Drug Delivery Systems / methods; Humans; Membranes, Artificial; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Nanotechnology / methods; Permeability; Porosity
TL;DR:
An overview of nanoporous membranes for biomedical applications, including biosensing, biosorting, immunoisolation, and drug delivery, are presented and desirable properties of membranes used in implantable devices, including biocompatibility and antibiofouling behavior are discussed.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Pulsed laser deposition of antimicrobial silver coating on Ormocer (R) microneedles
BIOFABRICATION, 1(4).
Contributors: S. Gittard, R. Narayan*, C. Jin*, A. Ovsianikov, B. Chichkov, * , S. Stafslien, B. Chisholm n
MeSH headings : Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Biotechnology; Cell Survival / drug effects; Ceramics / chemistry; Diffusion; Drug Delivery Systems / instrumentation; Humans; Keratinocytes; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Microtechnology / methods; Needles; Organically Modified Ceramics; Silanes / administration & dosage; Silanes / chemistry; Silver / administration & dosage; Silver / chemistry; Staphylococcus aureus / drug effects
TL;DR:
It is indicated that coating microneedles with silver thin films using pulsed laser deposition is a useful and novel approach for creating microneEDles with antimicrobial functionality.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Pulsed laser deposition of antimicrobial silver coating on Ormocer microneedles.
Biofabrication, 1(4), 041001. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:20661316&KeyUID=MEDLINE:20661316
Source: ORCID
Added: April 30, 2021
2009 journal article
Rapid prototyping of scaphoid and lunate bones
Biotechnology Journal, 4(1), 129–134.
Contributors: S. Gittard n, R. Narayan n, J. Lusk*, P. Morel *, F. Stockmans *, M. Ramsey*, C. Laverde*, J. Phillips*
MeSH headings : Analysis of Variance; Cell Survival; Compressive Strength; Computer-Aided Design; Elastic Modulus; Humans; Keratinocytes / metabolism; Lunate Bone / anatomy & histology; Materials Testing; Polymers / chemistry; Prostheses and Implants; Prosthesis Design / methods; Resins, Synthetic / chemistry; Scaphoid Bone / anatomy & histology; Tomography, X-Ray Computed
TL;DR:
The results of this study indicate that small bone prostheses fabricated by stereolithography using eShell 200 polymer may have suitable geometry, mechanical properties, and cytocompatibility properties for in vivo use.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 30, 2021
2009 book
Review of Federal Strategy for Nanotechnology-Related Environmental, Health, and Safety Research
Sources: Crossref, NC State University Libraries
Added: June 12, 2021
2009 journal article
Skin penetration and kinetics of pristine fullerenes (C-60) topically exposed in industrial organic solvents
TOXICOLOGY AND APPLIED PHARMACOLOGY, 242(1), 29–37.
Contributors: X. Xia n, n & J. Riviere n
author keywords: Dermal absorption; Stratum corneum; Nanomaterials; Fullerenes; Solvent effects; Nanotoxicity
MeSH headings : Algorithms; Animals; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Fullerenes / pharmacokinetics; Fullerenes / toxicity; Occupational Exposure / adverse effects; Particle Size; Skin / chemistry; Skin / pathology; Skin Absorption; Solvents / chemistry; Swine
TL;DR:
The solvent effects on the stratum corneum absorption of C60 were consistent with those observed in vivo; in vitro flow-through diffusion cell experiments were conducted in pig skin and fullerenes were not detected in the receptor solutions by 24 h.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Stretchable diamond-like carbon microstructures for biomedical applications
JOM, 61(9), 53–58.
Contributors: R. Boehm *, R. Narayan*, R. Aggarwal n, * & S. Lacour *
TL;DR:
The use of pulsed laser deposition is described to create diamond-like carbon microstructures on polydimethylsiloxane to demonstrate the viability of human epidermal keratinocyte cells onpolydimethyl Siloxane surfaces coated with arrays of diamond- like carbon islands.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 chapter
Anatomical factors that affect barrier function
In K. P. W. H. Zhai & H. I. Maibach (Eds.), Dematotoxicology (7th ed.) (pp. 39–50). Boca Raton: Wiley & Sons.
Ed(s): K. H. Zhai & H. Maibach
Source: NC State University Libraries
Added: August 6, 2018
2008 chapter
Animal skin morphology and dermal absorption
In M. S. Roberts & K. A. Walters (Eds.), Dermal absorption and toxicity assessment (2nd ed., pp. 17–35). New York: Informa Healthcare.
Ed(s): M. Roberts & K. Walters
Source: NC State University Libraries
Added: August 6, 2018
2008 article
Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin
SKIN PHARMACOLOGY AND PHYSIOLOGY, Vol. 21, pp. 166–180.
author keywords: quantum dots; nanoparticles; skin penetration; skin flexion; skin abrasion; tape-stripped skin
MeSH headings : Adhesives; Administration, Cutaneous; Animals; Dermabrasion; Microscopy, Confocal; Permeability; Quantum Dots; Rats; Rats, Wistar; Skin / metabolism; Skin Absorption; Spectrometry, Fluorescence
TL;DR:
The results indicate that the rat skin penetration of QD655 and QD565 is primarily limited to the uppermost stratum corneum layers of intact skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes
TOXICOLOGY AND APPLIED PHARMACOLOGY, 228(2), 200–211.
Contributors: L. Zhang n, W. Yu *, V. Colvin * & n
author keywords: quantum dot; nanoparticles; skin penetration; cytokines; keratinocytes; cellular uptake; inflammation; skin
MeSH headings : Animals; Cell Line; Cell Survival / drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Fluorescence; Fluorometry / methods; Humans; Hydrogen-Ion Concentration; Interleukins / metabolism; Keratinocytes / chemistry; Keratinocytes / drug effects; Keratinocytes / ultrastructure; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Particle Size; Polyethylene Glycols / chemistry; Quantum Dots; Receptor Protein-Tyrosine Kinases / metabolism; Receptor, EphA3; Spectrometry, Mass, Electrospray Ionization / methods; Swine; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Results indicate that porcine skin penetration of QD621 is minimal and limited primarily to the outer SC layers, yet if the skin were damaged allowing direct QD exposure to skin or keratinocytes, an inflammatory response could be initiated.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
COLL 95-Assessment of quantum dot nanoparticle penetration in human skin
Abstracts of Papers of the American Chemical Society, 236. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000270256303852&KeyUID=WOS:000270256303852
Source: ORCID
Added: June 27, 2019
2008 journal article
Characterization of microfluidic human epidermal keratinocyte culture
CYTOTECHNOLOGY, 56(3), 197–207.
Contributors: . Adrian T. O'Neill*, * & G. Walker*
author keywords: cytotoxicity; high-throughput; keratinocyte; microfluidic; PDMS; toxicology
TL;DR:
Human epidermal keratinocytes were shown to maintain 93.0%–99.6% viability at 72 h under medium perfusion ranging from 0.025–0.4 μl min−1, a level not possible in 96 well plates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Expression of Proinflammatory Cytokines by Human Mesenchymal Stem Cells in Response to Cyclic Tensile Strain
JOURNAL OF CELLULAR PHYSIOLOGY, 219(1), 77–83.
Contributors: R. Sumanasinghe*, T. Pfeiler*, n & E. Loboa*
MeSH headings : Animals; Bone Marrow Cells / cytology; Bone Marrow Cells / physiology; Cells, Cultured; Cytokines / metabolism; Humans; Interleukin-1beta / metabolism; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Stress, Mechanical; Stress, Physiological; Tensile Strength; Tumor Necrosis Factor-alpha / metabolism; Young Adult
TL;DR:
IL‐6 and IL‐8 expressions by hMSCs were induced by cyclic tensile strain and osteogenic differentiating media, indicating that IL‐ 6 andIL‐8 may be functioning as autocrine signals during osteogenic differentiation of h MSCs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line
TOXICOLOGY AND APPLIED PHARMACOLOGY, 234(2), 222–235.
author keywords: Carbon; Nanomaterials; Carbon black; Single-walled carbon nanotubes; C-60; nC(60); Quantum dots; Calcein AM; Live/Dead; NR; MTT; Celltiter 96 (R) AQueous One; Alamar Blue; Celltiter-Blue (R); CytoTox One (TM); Flow cytometry; Human epidermal keratinocytes; Toxicity; Viability assays
MeSH headings : Cell Line; Cell Survival / drug effects; Drug Evaluation, Preclinical; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Humans; Keratinocytes / drug effects; Light; Microscopy, Electron, Transmission; Nanoparticles / toxicity; Oxazines; Quantum Dots; Scattering, Radiation; Spectrophotometry, Ultraviolet; Tetrazolium Salts; Thiazoles; Trypan Blue; Xanthenes
TL;DR:
This study shows that, unlike small molecules, CNM interact with assay markers to cause variable results with classical toxicology assays and may not be suitable for assessing nanoparticle cytotoxicity, therefore, more than one assay may be required when determining nanoparticle toxicity for risk assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Mechanical and biological properties of nanoporous carbon membranes
BIOMEDICAL MATERIALS, 3(3).
Contributors: R. Narayan*, R. Aggarwal*, W. Wei*, C. Jin*, * , R. Crombez, W. Shen
MeSH headings : Carbon / administration & dosage; Carbon / chemistry; Cell Survival / drug effects; Cells, Cultured; Elasticity; Hardness; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Materials Testing; Membranes, Artificial; Nanostructures / administration & dosage; Nanostructures / chemistry; Nanostructures / ultrastructure; Particle Size; Porosity; Stress, Mechanical; Tensile Strength
TL;DR:
The structural, mechanical and biological properties of nanoporous alumina membranes coated with diamond-like carbon thin films were examined and it is anticipated that this novel membrane material could find use in immunoisolation devices, kidney dialysis membranes and other medical devices encountering biocompatibility issues that limit in vivo function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Nanoceria as antioxidant: Synthesis and biomedical applications
JOM, 60(3), 33–37.
Contributors: A. Karakoti *, n , R. Aggarwal n, J. Davis n, R. Narayan n, W. Self *, J. McGinnis*, S. Seal *
TL;DR:
The therapeutic application of nanomaterials has been a focus of numerous studies in the past decade, and the radical-scavenging role of ceria nanoparticles (nanoceria) have been established, as well as the autocatalytic ability of nanoceria to regenerate under various environmental conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 chapter
Solvents and vehicle effects on the skin
In M. S. Roberts & K. A. Walters (Eds.), Dermal absorption and toxicity assessment. (2nd ed.) (pp. 433–447). New York: Informa Healthcare.
Ed(s): M. Roberts & K. Walters
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Topical isoflavones provide effective photoprotection to skin
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, 24(2), 61–66.
Contributors: J. Lin*, J. Tournas, J. Burch, * & J. Zielinski
author keywords: antioxidants; isoflavones; photoprotection
MeSH headings : Administration, Cutaneous; Animals; Ascorbic Acid / administration & dosage; Ascorbic Acid / pharmacology; Ascorbic Acid / therapeutic use; Coumaric Acids / administration & dosage; Coumaric Acids / pharmacology; Coumaric Acids / therapeutic use; Dose-Response Relationship, Drug; Drug Combinations; Equol; Genistein / administration & dosage; Genistein / pharmacology; Genistein / therapeutic use; Isoflavones / administration & dosage; Isoflavones / pharmacology; Isoflavones / therapeutic use; Phytotherapy; Plants, Medicinal; Skin / drug effects; Skin / radiation effects; Sunburn / pathology; Sunburn / prevention & control; Sunlight / adverse effects; Sunscreening Agents / administration & dosage; Sunscreening Agents / pharmacology; Sunscreening Agents / therapeutic use; Swine; Vitamin E / administration & dosage; Vitamin E / pharmacology; Vitamin E / therapeutic use
TL;DR:
The aim of this study is to obtain a more comprehensive understanding of the isoflavone‐mediated photoprotection with the pig skin model, a more human‐resembling model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 chapter
Toxicological impacts of nanomaterials
In M. R. Wiesner & J. Y. Bottero (Eds.), Environmental nanotechnology: Applications and impacts of nanomaterials (pp. 395–444). New York: McGraw-Hill.
Ed(s): M. Wiesner & J. Bottero
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
A system coefficient approach for quantitative assessment of the solvent effects on membrane absorption from chemical mixtures
SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 18(5-6), 579–593.
Contributors: X. Xia n, R. Baynes n , n & J. Riviere n
author keywords: membrane absorption; chemical mixtures; solvent effects; system coefficient approach; solute descriptors
MeSH headings : Absorption; Dimethylpolysiloxanes / chemistry; Dimethylpolysiloxanes / metabolism; Kinetics; Membranes, Artificial; Models, Biological; Models, Chemical; Quantitative Structure-Activity Relationship; Regression Analysis; Silicones / chemistry; Silicones / metabolism; Solvents / chemistry
TL;DR:
A system coefficient approach is proposed for quantitative assessment of the solvent effects on membrane absorption from chemical mixtures using Polydimethylsiloxane membrane-coated fibres and 32 probe compounds to demonstrate the proposed approach.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber array
TOXICOLOGY AND APPLIED PHARMACOLOGY, 221(3), 320–328.
Contributors: X. Xia n, R. Baynes* , * & J. Riviere*
author keywords: skin permeability; predictive model; membrane-coated fiber; distribution coefficients; percutaneous absorption
MeSH headings : Algorithms; Complex Mixtures / chemistry; Complex Mixtures / pharmacokinetics; Forecasting; Humans; Membranes, Artificial; Models, Biological; Organic Chemicals / chemistry; Organic Chemicals / pharmacokinetics; Permeability; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / metabolism; Reproducibility of Results; Skin / metabolism; Skin Absorption / drug effects; Structure-Activity Relationship
TL;DR:
The MCF array approach is an experimentally based, high throughput approach that provides high prediction confidence and does not require literature data nor molecular structure information in contrast to the existing predictive models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 chapter
Animal skin morphology and dermal absorption
In Dermal Absorption and Toxicity Assessment, Second Edition (pp. 17–36). http://www.scopus.com/inward/record.url?eid=2-s2.0-77952889776&partnerID=MN8TOARS
Source: ORCID
Added: September 25, 2022
2007 journal article
Biodistribution of quantum dot nanoparticles in perfused skin: Evidence of coating dependency and periodicity in arterial extraction
NANO LETTERS, 7(9), 2865–2870.
Contributors: H. Lee n, M. Imran n, n , V. Colvin n, W. Yu n & J. Rivlere
MeSH headings : Animals; Arteries / chemistry; Coated Materials, Biocompatible / chemistry; Diffusion; Perfusion; Quantum Dots; Skin / blood supply; Skin / chemistry; Skin Absorption / physiology; Swine; Tissue Distribution
TL;DR:
Both QD had a unique periodicity in arterial extraction never observed with drug infusions, suggesting a potentially important nanomaterial behavior that could affect systemic disposition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Biological interactions of functionalized single-wall carbon nanotubes in human epidermal keratinocytes
INTERNATIONAL JOURNAL OF TOXICOLOGY, 26(2), 103–113.
Contributors: L. Zhang n, L. Zeng *, A. Barron * & n
author keywords: cytokines; keratmocytes; nanomaterials; nanotoxicology; single-wall carbon nanotubes; skin
MeSH headings : Aminocaproic Acid / chemistry; Cell Line; Cell Survival / drug effects; Cytokines / metabolism; Cytoplasmic Vesicles / drug effects; Cytoplasmic Vesicles / metabolism; Cytoplasmic Vesicles / ultrastructure; Dose-Response Relationship, Drug; Drug Antagonism; Drug Carriers / chemistry; Drug Carriers / toxicity; Drug Combinations; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Humans; Microscopy, Electron, Transmission; Nanotechnology; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Poloxamer / pharmacology; Surface-Active Agents / pharmacology
TL;DR:
Human epidermal keratinocytes (HEKs) were dosed with 6-Aminohexanoic acid–derivatized single-wall carbon nanotubes and data showed that the lower concentration of 0.000005 mg/ml of AHA-SWNTs maintains cell viability and induces a mild cytotoxicity, but the higher concentration demonstrated an irritation response by the increase in IL-8.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Biological properties of carbon nanotubes
Journal of Nanoscience and Nanotechnology, 7(4-5), 1284–1297.
Contributors: W. Wei n, A. Sethuraman, C. Jin, * & R. Narayan
author keywords: carbon nanotube; biocompatibility; deoxyribonucleic acid; tissue engineering; toxicity
MeSH headings : Animals; Biocompatible Materials / chemistry; Biophysics / methods; Carbon / chemistry; Cell Line; DNA / chemistry; Humans; Microscopy; Microscopy, Electron, Transmission; Nanotechnology / methods; Nanotubes, Carbon / chemistry; Neurons / metabolism; Nucleic Acids / chemistry; Time Factors; Tissue Engineering / methods
TL;DR:
In this review, the processing, chemical properties, physical properties, nucleic acid interaction, cell interaction, and toxicologic properties of nanotubes are described.
(via Semantic Scholar)
Source: ORCID
Added: June 27, 2019
2007 journal article
Cyclic tensile strain increases interactions between human epidermal keratinocytes and quantum dot nanoparticles
TOXICOLOGY IN VITRO, 22(2), 491–497.