Nancy A Monteiro-Riviere

Also known as: N.A. Monteiro-Riviere; Nancy A Monteiro-Riviere; Monteiro-Riviere NA

nanoparticle toxicity, protein corona, nanotoxicology, skin absorption, toxicity, skin penetration

Nancy A. Monteiro-Riviere PhD, ATS, was the Regents Distinguished Research Scholar and University Distinguished Professor and Founding Director of the Nanotechnology Innovation Center of Kansas State. She did a postdoctoral fellowship in toxicology at Chemical Industry Institute of Toxicology in RTP, NC. She was Professor of Investigative Dermatology and Toxicology at North Carolina State University (NCSU) for 28 years and Professor in the Joint Department of Biomedical Engineering at UNC-Chapel Hill/NCSU and Research Adjunct Professor of Dermatology, at UNC-Chapel Hill School of Medicine. She was past-President of both the Dermal and In Vitro Specialty sections of the Society of Toxicology and selected as an Eminent Toxicologist in March 2016 by the National Society of Toxicology. Dr. Monteiro-Riviere is a Fellow in The Academy of Toxicological Sciences and was elected to its Board of Directors. She was the recipient of the Purdue University Inaugural Distinguished Women Scholars Award, KSU Woman of Distinction, and elected to attend the National Academy of Sciences Keck Futures Initiative. She is Associate Editor for two and serves on the editorial board of six other toxicology journals; as well as on several national (NRC) and international (EU) expert review panels. She was on Thomson Reuters’s 2014 list of the top 1% most highly cited researchers in pharmacology and toxicology. She published over 330 manuscripts in skin toxicology and nanotoxicology and is Editor of three books in toxicology: “Nanotoxicology Characterization and Dosing and Health Effects”, “Toxicology of the Skin -Target Organ Series” and the latest in CRC Press “Nanotoxicology: Progress toward Nanomedicine”. Her research interests involve in vivo and in vitro studies of skin absorption, penetration and toxicity of chemicals, nanoparticles, and the effect of the biocorona on uptake and cellular responses to nanomaterials.

Works (387)

Updated: April 4th, 2024 04:46

2023 journal article

An artificial intelligence-assisted physiologically-based pharmacokinetic model to predict nanoparticle delivery to tumors in mice

JOURNAL OF CONTROLLED RELEASE, 361, 53–63.

author keywords: Artificial intelligence; Machine learning; Physiologically based pharmacokinetic; modeling; Nanomedicine; Drug delivery; Nanotechnology
TL;DR: An AI-assisted physiologically based pharmacokinetic (PBPK) model is established by integrating an AI-based quantitative structure-activity relationship (QSAR) model with a PBPK model to simulate tumor-targeted delivery efficiency (DE) and biodistribution of various NPs. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 7, 2023

2023 journal article

Meta-Analysis of Nanoparticle Distribution in Tumors and Major Organs in Tumor-Bearing Mice

ACS NANO, 17(20), 19810–19831.

author keywords: Nanoparticle; Tumor delivery; Tissue distribution; Cancer; Nanomedicine
TL;DR: An updated version of “Nano-Tumor Database” is reported, which increases the number of time-dependent concentration data sets for different nanoparticles (NPs) in tumors from the previous version of 376 data sets to 534 data sets with 2345 data points from 297 studies published from 2005 to 2021. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 10, 2023

2022 journal article

Biocorona modulates the inflammatory response induced by gold nanoparticles in human epidermal keratinocytes

Toxicology Letters, 369, 34–42.

By: X. Li*, D. Li*, G. Zhang*, Y. Zeng*, N. Monteiro-Riviere*, Y. Chang*, Y. Li*

MeSH headings : Antioxidants; Gold / chemistry; Gold / toxicity; Humans; Keratinocytes / metabolism; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; NF-E2-Related Factor 2 / genetics; Polyethyleneimine / chemistry; Protein Corona / chemistry; Protein Corona / metabolism; Thioctic Acid / pharmacology
TL;DR: It is discovered that nuclear factor erythroid-2 related factor (Nrf2), a major regulator of anti-oxidant and anti-inflammatory gene, is the key factor related to the AuNPs induced oxidative stress and inflammation. (via Semantic Scholar)
Source: ORCID
Added: August 7, 2023

2022 journal article

Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in rats

Particle and Fibre Toxicology, 19(1).

By: W. Chou*, Y. Cheng*, J. Riviere*, N. Monteiro-Riviere*, W. Kreyling* & Z. Lin*

Contributors: W. Chou*, Y. Cheng*, J. Riviere*, N. Monteiro-Riviere*, W. Kreyling* & Z. Lin*

author keywords: Biodistribution; Endocytosis; Gold nanoparticles; Nanomedicine; Nanotoxicology; Physiologically based pharmacokinetic (PBPK) modeling
MeSH headings : Animals; Bayes Theorem; Gold; Metal Nanoparticles; Models, Biological; Rats; Tissue Distribution
TL;DR: The size and surface area of AuNPs were the main determinants for endocytic/phagocytic uptake rates regardless of the route of administration, while Zeta potential was an important parameter for the estimation of the exocytic release rates following IV administration. (via Semantic Scholar)
Source: ORCID
Added: September 25, 2022

2022 review

Perspectives of nanotoxicology: Introduction

[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 14(6).

By: N. Monteiro-Riviere n

MeSH headings : Nanostructures / toxicity; Nanotechnology
TL;DR: This Nanotoxicology specialty issue begins with an overview of the methods used to conduct toxicokinetics, dose-response and risk assessment of nanomaterials: methodology, challenges, and future perspectives and specifically focuses on the experimen-tal design of plasma and tissue toxicokinetic. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 23, 2022

2022 journal article

Predicting Nanoparticle Delivery to Tumors Using Machine Learning and Artificial Intelligence Approaches

INTERNATIONAL JOURNAL OF NANOMEDICINE, 17, 1365–1379.

By: Z. Lin, W. Chou, Y. Cheng*, C. He*, N. Monteiro-Riviere n & J. Riviere n

Contributors: Z. Lin, W. Chou, Y. Cheng*, C. He*, N. Monteiro-Riviere n & J. Riviere n

author keywords: artificial intelligence; machine learning; physiologically based pharmacokinetic modeling; nanomedicine; drug delivery; nanotechnology
MeSH headings : Artificial Intelligence; Humans; Machine Learning; Nanoparticles; Neoplasms / drug therapy; Neural Networks, Computer
TL;DR: The deep neural network model adequately predicted the delivery efficiency of different NPs to different tumors and it outperformed all other machine learning methods; including random forest, support vector machine, linear regression, and bagged model methods. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 30, 2022

2021 journal article

The synergistic strategies for the immuno‐oncotherapy with photothermal nanoagents

WIREs Nanomedicine and Nanobiotechnology, 13(5).

Contributors: Y. Zhang*, G. Zhang*, G. Wang*, L. Wu*, N. Monteiro-Riviere* & Y. Li*

author keywords: immune checkpoints; immuno‐ oncotherapy; nanomaterials; nanoagents; photothermal therapy; synergistic oncotherapy
MeSH headings : Adjuvants, Immunologic; Humans; Immunotherapy; Nanomedicine; Nanostructures; Neoplasms / therapy; Photothermal Therapy
TL;DR: This review summarizes the recent studies on the synergistic strategies for the immuno-oncotherapy based on photothermal nanoagents and the mechanisms that trigger the systemic anti-tumor immune responses and PTT-synergized immunosuppressive conditions simultaneously. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 26, 2021

2020 journal article

Amino/Amido Conjugates Form to Nanoscale Cobalt Physiometacomposite (PMC) Materials Functionally Delivering Nucleic Acid Therapeutic to Nucleus Enhancing Anticancer Activity via Ras-Targeted Protein Interference

ACS Applied Bio Materials, 3(1), 175–179.

By: R. DeLong*, J. Dean*, G. Glaspell*, M. Jaberi-Douraki*, K. Ghosh*, D. Davis*, N. Monteiro-Riviere*, P. Chandran* ...

Contributors: R. Delong*, J. Dean*, G. Glaspell*, M. Jaberi-Douraki*, K. Ghosh*, D. Davis*, N. Monteiro-Riviere*, P. Chandran* ...

author keywords: PMC; ZnO; cobalt; nickel; B16F10; HEK; A375
TL;DR: Preclinical potential of PMC for delivery of SSO, RBD, or other nucleic acid therapeutic and anticancer peptides is suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: January 8, 2020

2020 content posted

Gold Nanoparticles Induce Cell Stress by Interfering with the Cellular Protein Quality Control System

By: G. Zhang*, Q. Song*, Y. Zhang*, R. Liang*, L. Chen*, N. Monteiro-Riviere*, D. Boraschi, Y. Chang*, H. Li*, Y. Li*

TL;DR: This study for the first time shows that NPs can interfere with the cellular PQC system by impairing ERAD activity, which in turn initiates a cascade of events leading to cell death and inflammation. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: October 16, 2020

2020 article

Gold Nanoparticles Induce Cell Stress by Interfering with the Cellular Protein Quality Control System

ResearchSquare.

By: G. Zhang, Q. Song, Y. Zhang, R. Liang, L. Chen, N. Monteiro-Riviere, D. Boraschi, Y. Chang, H. Li, Y. Li

Contributors: G. Zhang, Q. Song, Y. Zhang, R. Liang, L. Chen, N. Monteiro-Riviere, D. Boraschi, Y. Chang, H. Li, Y. Li

Source: ORCID
Added: September 25, 2022

2020 journal article

Meta-Analysis of Nanoparticle Delivery to Tumors Using a Physiologically Based Pharmacokinetic Modeling and Simulation Approach

ACS Nano, 14(3), 3075–3095.

By: Y. Cheng*, C. He*, J. Riviere*, N. Monteiro-Riviere* & Z. Lin*

Contributors: Y. Cheng*, C. He*, J. Riviere*, N. Monteiro-Riviere* & Z. Lin*

author keywords: advanced material; drug delivery; nanomedicine; nanoparticle; physiologically based pharmacokinetic modeling; tissue biothstribution; tumor delivery
MeSH headings : Animals; Disease Models, Animal; Drug Carriers / chemistry; Drug Delivery Systems; Gold / administration & dosage; Gold / chemistry; Gold / pharmacokinetics; Injections, Intravenous; Male; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Neoplasms / chemistry; Neoplasms / metabolism; Tissue Distribution
TL;DR: The potential causes of this poor delivery efficiency were explored using the more mechanistic PBPK perspective applied to a subset of gold nanoparticles and it was found that low delivery efficiency was associated with low distribution and permeability coefficients at the tumor site. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: March 5, 2020

2019 journal article

Toxicity assessment of six titanium dioxide nanoparticles in human epidermal keratinocytes

Cutaneous and Ocular Toxicology, 38(1), 66–80.

By: L. Zhang* & N. Monteiro-Riviere*

Contributors: L. Zhang* & N. Monteiro-Riviere*

author keywords: Titanium dioxide nanoparticles; human epidermal keratinocytes; cell viability; cytokine release; cellular uptake
MeSH headings : Cells, Cultured; Cytokines / metabolism; Humans; Keratinocytes / drug effects; Keratinocytes / metabolism; Metal Nanoparticles / toxicity; Titanium / toxicity
TL;DR: Based on cell viability, only sample B was slightly cytotoxic to HEK and samples B and A* have the potential to cause inflammation indicated by an increase in IL-6. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: June 27, 2019

2018 journal article

Modeling gold nanoparticle biodistribution after arterial infusion into perfused tissue: effects of surface coating, size and protein corona

Nanotoxicology, 12(10), 1093–1112.

By: J. Riviere*, M. Jaberi-Douraki*, J. Lillich*, T. Azizi*, H. Joo*, K. Choi*, R. Thakkar*, N. Monteiro-Riviere*

Contributors: J. Riviere*, M. Jaberi-Douraki*, J. Lillich*, T. Azizi*, H. Joo*, K. Choi*, R. Thakkar*, N. Monteiro-Riviere*

author keywords: Biodistribution; gold nanoparticles; cell uptake; skin; pharmacokinetics; nanoparticle vascular distribution
MeSH headings : Animals; Epigastric Arteries; Female; Free Tissue Flaps; Gold / administration & dosage; Gold / chemistry; Gold / pharmacokinetics; Humans; Infusions, Intra-Arterial; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Models, Biological; Nanomedicine; Particle Size; Perfusion; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / chemistry; Skin / blood supply; Skin / metabolism; Surface Properties; Swine; Thioctic Acid / chemistry; Tissue Distribution
TL;DR: These studies paralleled previous in vitro cell culture studies using the same AuNP in human endothelial and renal proximal tubule cells, hepatocytes, keratinocytes, showing BPEI-AuNP having the greatest uptake, although the presence of a PPC did not reduce IPPSF biodistribution as in the cellculture studies. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: June 27, 2019

2018 journal article

Probabilistic risk assessment of gold nanoparticles after intravenous administration by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling

Nanotoxicology, 12(5), 453–469.

By: Y. Cheng*, J. Riviere*, N. Monteiro-Riviere* & Z. Lin*

Contributors: Y. Cheng*, J. Riviere*, N. Monteiro-Riviere* & Z. Lin*

author keywords: Gold nanoparticle; computational nanotoxicology; physiologically based pharmacokinetic modeling; probabilistic risk assessment
MeSH headings : Administration, Intravenous; Animals; Bayes Theorem; Gold / administration & dosage; Gold / pharmacokinetics; Gold / toxicity; Humans; Metal Nanoparticles / toxicity; Models, Biological; Monte Carlo Method; Risk Assessment
TL;DR: The results suggest that under the highest dosing level employed in existing animal studies (worst-case scenario), AuNPs coated with branched polyethylenimine (BPEI) would likely induce ∼90–100% cellular death, implying high cytotoxicity compared to <10% cell death induced by low-to-medium animal dosing levels, which are commonly used in animal studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref
Added: June 27, 2019

2017 journal article

Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation

Nanotoxicology, 11(9-10), 1157–1175.

By: Y. Li*, Z. Shi*, I. Radauer-Preiml*, A. Andosch*, E. Casals*, U. Luetz-Meindl*, M. Cobaleda*, Z. Lin* ...

Contributors: Y. Li*, Z. Shi*, I. Radauer-Preiml*, A. Andosch*, E. Casals*, U. Luetz-Meindl*, M. Cobaleda*, Z. Lin* ...

author keywords: Nano-immunosafety; endotoxin contamination; biocorona modulation; gold nanoparticles; inflammatory effects
MeSH headings : Adsorption; Blood Proteins / chemistry; Computational Biology; Gold / chemistry; Gold / toxicity; HEK293 Cells; Humans; Inflammation; Interleukin-1 / biosynthesis; Lipopolysaccharides / chemistry; Lipopolysaccharides / toxicity; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Models, Biological; Monocytes / drug effects; Monocytes / immunology; Particle Size; Protein Corona / analysis; Surface Properties
TL;DR: The unintentional adsorption of LPS onto the NP surface can affect the biocorona formation and the inflammatory properties of NPs. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021

2017 journal article

Biocorona formation on gold nanoparticles modulates human proximal tubule kidney cell uptake, cytotoxicity and gene expression

Toxicology in Vitro, 42, 150–160.

By: M. Ortega*, J. Riviere*, K. Choi* & N. Monteiro-Riviere*

author keywords: Gold nanoparticles; Human proximal tubule cells; Protein corona; Cellular uptake; Gene expression; Mechanisms of toxicity
MeSH headings : Cells, Cultured; Cytokines / metabolism; Gene Expression / drug effects; Gold / administration & dosage; Gold / chemistry; Gold / toxicity; Humans; Kidney Tubules, Proximal / cytology; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Plasma / chemistry; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / chemistry; Serum Albumin / chemistry; Thioctic Acid / chemistry
TL;DR: These studies clearly showed reduced uptake and cytotoxicity, as well as differentiated gene expression of AuNP with PCs, questioning the utility of in vitro studies using bare NP to assess in vivo effects, suggesting the relative safety of PEG and LA-AuNP as nanomedicine constructs. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: June 27, 2019

2017 chapter

Multi-walled carbon nanotube exposure alters protein expression in human keratinocytes

In Nanomedicine in Cancer (pp. 461–485).

By: F. Witzmann & N. Monteiro-Riviere

Contributors: F. Witzmann & N. Monteiro-Riviere

Source: ORCID
Added: September 25, 2022

2017 chapter

Skin

In Adverse Effects of Engineered Nanomaterials (pp. 357–380).

By: N. Monteiro-Riviere* & F. Filon*

Contributors: N. Monteiro-Riviere* & F. Filon*

TL;DR: The role of the skin as a potential route of exposure to nanomaterials is described in the present chapter and in vitro systems and differences in animal species provide limitations for a complete understanding of nanoparticle penetration through the skin. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 26, 2021

2017 journal article

Surface chemistry of gold nanoparticles determines the biocorona composition impacting cellular uptake, toxicity and gene expression profiles in human endothelial cells

Nanotoxicology, 11(4), 507–519.

By: P. Chandran*, J. Riviere* & N. Monteiro-Riviere*

Contributors: P. Chandran*, J. Riviere* & N. Monteiro-Riviere*

author keywords: Biocorona; gold nanoparticles; surface chemistry; endothelial cells; mechanistic toxicology
MeSH headings : Albumins / metabolism; Cell Survival / drug effects; Circular Dichroism; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Gold / chemistry; Gold / toxicity; Human Umbilical Vein Endothelial Cells; Humans; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Particle Size; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / metabolism; Proteomics; Surface Properties; Transcriptome / drug effects
TL;DR: NP surface chemistry is shown to play the dominant role over size in determining the biocorona composition, which in turn modulates cell uptake, and biological responses, consequently defining the potential safety and efficacy of nanoformulations. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID, Web Of Science
Added: April 29, 2021

2016 journal article

A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles

Nanomedicine, 11(2), 107–119.

By: Z. Lin*, N. Monteiro-Riviere*, R. Kannan* & J. Riviere*

Contributors: Z. Lin*, N. Monteiro-Riviere*, R. Kannan* & J. Riviere*

author keywords: biodistribution; computational nanotoxicology; endocytosis; nanomaterials; PBPK modeling; physiologically based pharmacokinetic modeling; phagocytosis; toxicokinetics
MeSH headings : Animals; Cell Survival / drug effects; Computer Simulation; Dose-Response Relationship, Drug; Environmental Exposure / adverse effects; Gold / pharmacokinetics; Gold / toxicity; Humans; Metabolic Clearance Rate; Mice; Models, Biological; Nanoparticles / toxicity; Rats; Species Specificity; Swine; Tissue Distribution; Toxicity Tests / methods
TL;DR: These results partially explain the current low translation rate of nanotechnology-based drug delivery systems from mice to humans and may be applied to other nanomaterials and provides guidance to design future translational studies. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021

2016 journal article

A physiologically based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice

Nanotoxicology, 10(2), 162–172.

By: Z. Lin*, N. Monteiro-Riviere* & J. Riviere*

Contributors: Z. Lin*, N. Monteiro-Riviere* & J. Riviere*

author keywords: Biodistribution; endocytosis; gold nanoparticles; pharmacokinetics; PBPK modeling
MeSH headings : Animals; Calibration; Computer Simulation; Endocytosis / physiology; Gold / pharmacokinetics; Humans; Metal Nanoparticles / chemistry; Mice; Models, Biological; Particle Size; Polyethylene Glycols / pharmacokinetics; Tissue Distribution
TL;DR: A membrane-limited physiologically based pharmacokinetic (PBPK) model for polyethylene glycol-coated gold (Au) NPs (PEG- coated AuNPs) was developed in mice, providing useful insights into the size, time, and species dependence of NP pharmacokinetics. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021

2016 journal article

Assessing the safety of cosmetic chemicals: Consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)

Regulatory Toxicology and Pharmacology, 76, 174–186.

By: F. Williams*, H. Rothe, G. Barrett*, A. Chiodini*, J. Whyte*, M. Cronin*, N. Monteiro-Riviere*, J. Plautz ...

Contributors: F. Williams*, H. Rothe, G. Barrett*, A. Chiodini*, J. Whyte*, M. Cronin*, N. Monteiro-Riviere*, J. Plautz ...

author keywords: Threshold of Toxicological Concern (TTC); Dermal; Cosmetic chemical; Systemic bioavailability; Decision tree; Prediction; Flux
MeSH headings : Administration, Cutaneous; Administration, Oral; Algorithms; Animals; Biological Availability; Consumer Product Safety; Cosmetics / administration & dosage; Cosmetics / pharmacokinetics; Cosmetics / toxicity; Decision Trees; Dose-Response Relationship, Drug; Humans; Intestinal Absorption; Models, Biological; No-Observed-Adverse-Effect Level; Risk Assessment; Skin / metabolism; Skin Absorption; Toxicity Tests / methods
TL;DR: The objective here was to explore the potential refinement of exposure for applying the oral TTC to chemicals found in cosmetic products, for which there are limited dermal absorption data. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021

2016 journal article

Biocorona Bound Gold Nanoparticles Augment Their Hematocompatibility Irrespective of Size or Surface Charge

ACS Biomaterials Science & Engineering, 2(9), 1608–1618.

By: A. Sasidharan*, P. Chandran* & N. Monteiro-Riviere*

Contributors: A. Sasidharan*, P. Chandran* & N. Monteiro-Riviere*

author keywords: gold nanoparticles; nanoparticle surface chemistry; protein corona; hematotoxicity; blood components
TL;DR: It is suggested that, irrespective of the physicochemical properties, the adsorption of the PC over AuNP significantly influences its biological impact by alleviating adverse hematotoxicity of bare NP. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021

2016 chapter

Cell and Protein Interactions with Diamond

In R. Bawa, G. F. Audette, & B. Reese (Eds.), Handbook of Clinical Nanomedicine: Law, Business, Regulation, Safety and Risk (pp. 809–822).

By: R. Narayan, R. Boehm & N. Monteiro-Riviere

Contributors: R. Narayan, R. Boehm & N. Monteiro-Riviere

Ed(s): R. Bawa, G. Audette & B. Reese

Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: December 6, 2018

2016 journal article

Intracellular imaging of quantum dots, gold, and iron oxide nanoparticles with associated endocytic pathways

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 9(2), e1419.

By: D. Chen*, N. Monteiro-Riviere* & L. Zhang*

Contributors: D. Chen*, N. Monteiro-Riviere* & L. Zhang*

MeSH headings : Animals; Cell Line; Cell Membrane / chemistry; Cell Membrane / metabolism; Endocytosis / physiology; Gold; Humans; Intracellular Space / chemistry; Intracellular Space / diagnostic imaging; Intracellular Space / metabolism; Membrane Microdomains; Metal Nanoparticles; Mice; Molecular Imaging / methods; Nanomedicine; Quantum Dots
TL;DR: Knowing the different methodologies used to determine the endocytic pathways will increase the understanding of NP toxicity, cancer cell targeting, and imaging, so that surface coatings can be created for efficient cell uptake of metallic NP with minimal cytotoxicity. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 26, 2021

2016 journal article

Mechanisms of cell uptake, inflammatory potential and protein corona effects with gold nanoparticles

Nanomedicine, 11(24), 3185–3203.

By: Y. Li* & N. Monteiro-Riviere*

Contributors: Y. Li* & N. Monteiro-Riviere*

author keywords: endocytosis; gold nanoparticles; human epidermal keratinocytes; inflammation; mechanisms of cellular uptake; protein corona
MeSH headings : Blood Proteins / metabolism; Cells, Cultured; Endocytosis / drug effects; Gold / chemistry; Gold / pharmacology; Humans; Inflammation / chemically induced; Inflammation / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Metal Nanoparticles / chemistry; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / metabolism; Thioctic Acid / chemistry
TL;DR: Results suggest protein coronas significantly affect cellular uptake and inflammatory responses of AuNP, and suggest BPEI-AuNP showed the greatest uptake, while PEG- auNP had the least. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021

2016 journal article

Mechanistic Toxicity Assessment of Hexahydroisohumulone in Canine Hepatocytes, Renal Proximal Tubules, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like Cells

International Journal of Veterinary Health Science & Research, 4(2), 88–103.

By: K. Choi*, J. Koci*, M. Ortega*, B. Jeffery, J. Riviere* & N. Monteiro Riviere*

TL;DR: Investigating organ-specific oxidative stress and the molecular mechanism of toxicity using the pathway-focused DNA array of the hop ingredient hexahydroisohumulone with canine hepatocytes, canine proximal tubule cells, bone marrow-derived mesenchymal stem cells and enterocyte-like cells provides insight into genes altered with HEX exposure and the cell-type specific responses in dogs. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 29, 2021

2016 journal article

Oxidative stress response in canine in vitro liver, kidney and intestinal models with seven potential dietary ingredients

Toxicology Letters, 241, 49–59.

By: K. Choi*, M. Ortega*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

Contributors: K. Choi*, M. Ortega*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

author keywords: In vitro canine culture systems; Multiple organ-derived cells; Dietary ingredients; Organ-specific oxidative stress
MeSH headings : Animals; Antioxidants / chemistry; Antioxidants / pharmacology; Bone Marrow Cells / drug effects; Bone Marrow Cells / metabolism; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Food; Food Analysis; Hepatocytes / drug effects; Intestinal Mucosa / metabolism; Intestines / drug effects; Kidney / drug effects; Kidney / metabolism; Kidney Tubules, Proximal / cytology; Kidney Tubules, Proximal / drug effects; Liver / drug effects; Liver / metabolism; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Oxidants / toxicity; Oxidative Stress / drug effects
TL;DR: The results suggest that organ-specific responses to oxidative stress by these potential prooxidant compounds may implicate a mechanism of their toxicities. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021

2016 journal article

Protein corona modulation of hepatocyte uptake and molecular mechanisms of gold nanoparticle toxicity

Nanotoxicology, 11(1), 64–75.

By: K. Choi*, J. Riviere* & N. Monteiro-Riviere*

Contributors: K. Choi*, J. Riviere* & N. Monteiro-Riviere*

author keywords: Gold nanoparticles; human hepatocytes; cell uptake; cytochrome P450; mechanisms of action
MeSH headings : Albumins / chemistry; Blood Proteins / chemistry; Cell Survival / drug effects; Dose-Response Relationship, Drug; Gene Expression Profiling; Gold / chemistry; Gold / metabolism; Gold / toxicity; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / metabolism; Reactive Oxygen Species / metabolism; Transcriptome / drug effects
TL;DR: Human hepatic uptake of 40 and 80 nm AuNP with branched polyethylenimine (BPEI), lipoic acid (LA) and polyethylene glycol (PEG) coatings as well as human plasma protein (HP) and human serum albumin (HSA) coronas was investigated to better understanding of the dramatic effect of protein coronas (PC) on AuNP cellular uptake, cytotoxicity and their underlying molecular mechanisms of action. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 27, 2021

2016 journal article

Quantification of nanoparticle pesticide adsorption: computational approaches based on experimental data

Nanotoxicology, 10(8), 1118–1128.

By: R. Chen*, Y. Zhang*, N. Monteiro-Riviere* & J. Riviere*

Contributors: R. Chen*, Y. Zhang*, N. Monteiro-Riviere* & J. Riviere*

author keywords: BSAI; in situ characterization; nanoparticles; pesticide; surface physicochemistry
MeSH headings : Adsorption; Models, Theoretical; Nanoparticles / analysis; Nanoparticles / chemistry; Neural Networks, Computer; Pesticides / analysis; Pesticides / chemistry; Principal Component Analysis; Surface Properties
TL;DR: The first attempt of the application of such quantitative measures toward environmental endpoints by analyzing the interactions of a selected group of nanomaterials with a variety of pesticides was made and quantitative computational approaches support theApplication of BSAI modeling in the area of environmental contamINANt detection and remediation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021

2016 chapter

Safety of Nanoparticle Skin Penetration

In Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement (pp. 363–376).

By: N. Monteiro-Riviere*

Contributors: N. Monteiro-Riviere*

TL;DR: This review shows the skin is an important route of exposure to nanomaterials after occupational, environmental, and consumer product usage and there are many challenges that must be overcome before nanotechnology is applied to the field of nanomedicine and prior to conducting science-based occupational or environmental exposure risk assessments. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021

2016 journal article

Toxicological effects of pet food ingredients on canine bone marrow-derived mesenchymal stem cells and enterocyte-like cells

Journal of Applied Toxicology, 36(2), 189–198.

By: M. Ortega*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

Contributors: M. Ortega*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

author keywords: canine; bone marrow stem cells; enterocyte like cells; adult stem cell differentiation; essential oils; cytotoxicity; mesenchymal stem cells; in vitro
MeSH headings : Acrolein / analogs & derivatives; Acrolein / toxicity; Animal Feed / toxicity; Animals; Bone Marrow / drug effects; Citric Acid / toxicity; Clove Oil / toxicity; Cytotoxins / toxicity; Dogs; Enterocytes / drug effects; Eugenol / toxicity; Ginger / toxicity; Guanosine Monophosphate / toxicity; Inosine Monophosphate / toxicity; Mesenchymal Stem Cells / drug effects; Oils, Volatile / toxicity; Pets; Plant Oils / toxicity; Plant Roots / toxicity; Sorbose / toxicity; Thymol / toxicity
TL;DR: These studies provide a baseline against which differential toxicity of dietary feed ingredients can be assessed in vitro for direct effects on canine cells and demonstrate differential toxicity in differentiated cells that represent gastrointestinal epithelial cells. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021

2015 journal article

Biomedical applications of gold nanomaterials: opportunities and challenges

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 7(6), 779–796.

By: A. Sasidharan* & N. Monteiro-Riviere*

Contributors: A. Sasidharan* & N. Monteiro-Riviere*

MeSH headings : Animals; Biocompatible Materials / chemistry; Biosensing Techniques; Cell Line, Tumor; Diagnostic Imaging; Drug Delivery Systems; Gold / chemistry; Humans; Immunoglobulin G / chemistry; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Nanomedicine / methods; Photochemistry; Photochemotherapy / methods; Spectrum Analysis, Raman; Surface Properties
TL;DR: This review summarizes the recent research on the applications of AuNM with a focus on biomedical diagnostics and therapeutics and the bio-interaction of these NM with cells and their in vivo responses are presented. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 30, 2021

2015 journal article

Comparative In Vitro Cytotoxicity of 20 Potential Food Ingredients in Canine Liver, Kidney, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like Cells

Applied In Vitro Toxicology, 1(4), 276–288.

By: N. Monteiro-Riviere*, M. Ortega*, K. Choi*, J. Koci*, Z. Lin*, B. Jeffery, J. Riviere*

TL;DR: Dose–response cytotoxicity studies and LC50 using alamar blue assays are reported for seven additional compounds: denatonium benzoate, eucalyptol, hexahydro isohumulone, tetrahydroisohumULone, green tea catechin extract, epigallocatechin gallate, and sodium copper chlorophyllin. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 30, 2021

2015 chapter

Dermatotoxicity of Nanomaterials

In B. Fadeel (Ed.), Handbook of Safety Assessment of Nanomaterials: From Toxicological Testing to Personalized Medicine (pp. 439–459,). Boca Raton, FL: Jenny Stanford Publishing.

By: N. Monteiro-Riviere & J. Riviere

Ed(s): B. Fadeel

Source: NC State University Libraries
Added: June 12, 2021

2015 journal article

Gold and silver nanoparticle interactions with human proteins: impact and implications in biocorona formation

Journal of Materials Chemistry B, 3(10), 2075–2082.

By: A. Sasidharan*, J. Riviere* & N. Monteiro-Riviere*

Contributors: A. Sasidharan*, J. Riviere* & N. Monteiro-Riviere*

TL;DR: Findings suggest that irrespective of NP surface chemistry or chemical composition, corona proteins at their physiological concentrations interact rather differently; wherein HSA and IgG coronas adsorbed strongly on the NP surface and kept both Au and AgNP well dispersed, while fibrinogen caused rapid, strong and irreversible agglomeration. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 3, 2021

2015 chapter

In Vitro and In Vivo Toxicity and Pharmacokinetics of Silver Nanoparticles

In Encyclopedia of Nanotechnology (pp. 1–14).

By: M. Samberg*, Z. Lin* & N. Monteiro-Riviere*

Sources: Crossref, NC State University Libraries
Added: April 26, 2021

2015 journal article

In vitro safety assessment of food ingredients in canine renal proximal tubule cells

Toxicology in Vitro, 29(2), 289–298.

By: J. Koči*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

Contributors: J. Koči*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

author keywords: Food ingredients; Canine; Proximal tubule cells; Lemongrass oil; Gene expression; Metabolic pathway
MeSH headings : Acrolein / analogs & derivatives; Acrolein / toxicity; Aminophenols / toxicity; Animals; Cell Survival / drug effects; Citric Acid / toxicity; Dogs; Eugenol / toxicity; Food Safety; Gene Expression Profiling; Ginger; Guanosine Monophosphate / toxicity; Humans; Inosine Monophosphate / toxicity; Kidney Tubules, Proximal / cytology; Oils, Volatile / toxicity; Plant Extracts / toxicity; Plant Oils / toxicity; Plant Roots; Sorbose / toxicity; Terpenes / toxicity; Thymol / toxicity; Thymus Plant; Toxicity Tests / methods; Xylitol / toxicity
TL;DR: Viability assays along with mechanistic studies in the CPTC model may serve as a valuable in vitro toxicity screening tool. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 3, 2021

2015 journal article

Predicting the impact of biocorona formation kinetics on interspecies extrapolations of nanoparticle biodistribution modeling

Nanomedicine, 10(1), 25–33.

By: F. Sahneh*, C. Scoglio*, N. Monteiro-Riviere* & J. Riviere*

Contributors: F. Sahneh*, C. Scoglio*, N. Monteiro-Riviere* & J. Riviere*

author keywords: allometry; biocorona; interspecies extrapolation; in vitro-in vivo correlation; nanomaterials; nanoparticle biodistribution
MeSH headings : Animals; Humans; Kinetics; Mice; Models, Theoretical; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Pharmacokinetics; Rats; Surface Properties; Tissue Distribution
TL;DR: While engineered NPs can successfully reach target cells in rodent models, the results may be different in humans due to the fact that the longer circulation time allows for further biocorona evolution. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 30, 2021

2015 journal article

Safety assessment of potential food ingredients in canine hepatocytes

Food and Chemical Toxicology, 78, 105–115.

By: L. Zhang*, J. Koci*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

Contributors: L. Zhang*, J. Koci*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

MeSH headings : Acetaminophen / toxicity; Acrolein / analogs & derivatives; Acrolein / toxicity; Aflatoxin B1 / toxicity; Animal Feed / standards; Animals; Cell Line; Cell Survival / drug effects; Dogs; Down-Regulation; Eugenol / toxicity; Food Analysis; Food Safety; Ginger / chemistry; Ginger / toxicity; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Lethal Dose 50; Oils, Volatile / toxicity; Plant Extracts / toxicity; Plant Oils / toxicity; Plant Roots / chemistry; Plant Roots / toxicity; Rats; Terpenes / toxicity; Thymol / toxicity; Up-Regulation; Xylitol / toxicity
TL;DR: In vitro assays such as this may be useful for hazard assessment of food ingredients for altered hepatic function, which CYP and heat shock most affected. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 30, 2021

2014 chapter

Dermal Exposure and Absorption of Chemicals and Nanomaterials

In Reference Module in Biomedical Sciences.

By: J. Riviere* & N. Monteiro-Riviere*

Sources: Crossref, NC State University Libraries
Added: May 30, 2021

2014 journal article

Growth of Zircone on Nanoporous Alumina Using Molecular Layer Deposition

JOM, 66(4), 649–653.

By: R. Hall*, S. George*, Y. Kim*, W. Hwang*, M. Samberg n, N. Monteiro-Riviere n, R. Narayan n

Contributors: R. Hall*, S. George*, Y. Kim*, W. Hwang*, M. Samberg n, N. Monteiro-Riviere n, R. Narayan n

Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

In Vitro Biocompatibility and Antibacterial Efficacy of a Degradable Poly(L-lactide-co-epsilon-caprolactone) Copolymer Incorporated with Silver Nanoparticles

ANNALS OF BIOMEDICAL ENGINEERING, 42(7), 1482–1493.

By: M. Samberg n, P. Mente n, T. He n, M. King n & N. Monteiro-Riviere n

Contributors: M. Samberg n, P. Mente n, T. He n, M. King n & N. Monteiro-Riviere n

author keywords: Nanoparticle; Keratinocyte; Skin tissue engineering; Scaffold; Biocompatibility
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biodegradable Plastics / chemistry; Biodegradable Plastics / pharmacology; Cell Proliferation / drug effects; Epidermal Cells; Epidermis / metabolism; Humans; Keratinocytes / cytology; Keratinocytes / metabolism; Materials Testing; Metal Nanoparticles / chemistry; Polyesters / chemistry; Polyesters / pharmacology; Silver / chemistry; Silver / pharmacology; Tissue Engineering
TL;DR: Findings suggest that a scaffold containing between 0.5 and 1.0 mg(Ag) g(scaffold)−1 is both biocompatible and antibacterial, and is suitable for skin tissue engineering graft scaffolds. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Nanoparticle Surface Characterization and Clustering through Concentration-Dependent Surface Adsorption Modeling

ACS Nano, 8(9), 9446–9456.

By: R. Chen, Y. Zhang, F. Darabi Sahneh, C. Scoglio, W. Wohlleben*, A. Haase*, N. Monteiro-Riviere*, J. Riviere*

Contributors: R. Chen, Y. Zhang, F. Darabi Sahneh, C. Scoglio, W. Wohlleben*, A. Haase*, N. Monteiro-Riviere*, J. Riviere*

author keywords: BSAI; nanoparticles; nanomedicine; nanotoxicology surface physicochemistry; in situ characterization
MeSH headings : Adsorption; Models, Molecular; Nanoparticles / chemistry; Surface Properties
TL;DR: The approach beyond the application of five descriptors in the original BSAI to address the concentration dependence of the descriptors, enabling better prediction of the adsorption profile and more accurate categorization of nanomaterials based on their surface properties is advanced. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: June 12, 2021

2014 book

Nanotoxicology: Progress toward Nanomedicine

(2nd ed.).

Nancy Monteiro-Riviere

Ed(s): N. Monteiro-Riviere & C. Tran

Sources: Crossref, NC State University Libraries
Added: June 12, 2021

2014 journal article

Pharmacokinetics of metallic nanoparticles

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 7(2), 189–217.

By: Z. Lin*, N. Monteiro-Riviere* & J. Riviere*

Contributors: Z. Lin*, N. Monteiro-Riviere* & J. Riviere*

MeSH headings : Animals; Humans; Metal Nanoparticles / chemistry; Models, Biological; Pharmacokinetics
TL;DR: Physiologically based pharmacokinetic models for gold/dendrimer composite nanodevices, AgNPs, and TiO2 NP models have been developed in rats and extrapolated to humans to support risk assessment and nanomedicine applications. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 30, 2021

2014 chapter

Safety Implications of Nanomaterial Exposure to Skin

In N. A. Monteiro-Riviere & C. L. Tran (Eds.), Nanotoxicology: Progress toward nanomedicine (2nd ed., pp. 267–292).

By: N. Monteiro-Riviere

Ed(s): N. Monteiro-Riviere & C. Tran

UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: June 12, 2021

2014 chapter

Silver Nanoparticles in Biomedical Applications

In N. A. Monteiro-Riviere & C. Lang Tran (Eds.), Nanotoxicology: Progress toward Nanomedicine (2nd ed., pp. 425–442).

By: M. Samberg & N. Monteiro-Riviere

Ed(s): N. Monteiro-Riviere & C. Lang Tran

Sources: Crossref, NC State University Libraries
Added: June 12, 2021

2014 journal article

Two-photon polymerization/micromolding of microscale barbs for medical applications

Journal of Adhesion Science and Technology, 28(3-4), 387–398.

By: R. Boehm n, B. Chen n, S. Gittard n, B. Chichkov n, N. Monteiro-Riviere n, A. Nasir*, R. Narayan n

Contributors: R. Boehm n, B. Chen n, S. Gittard n, B. Chichkov n, N. Monteiro-Riviere n, A. Nasir*, R. Narayan n

author keywords: tissue barb; wound sealant; two-photon polymerization; micromolding; indirect rapid prototyping
TL;DR: The results suggest that two-photon polymerization/micromolding is an indirect rapid prototyping approach that may be used for high-throughput replication of tissue barbs and other microstructured solid wound sealants. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2013 journal article

Biocompatibility analysis of an electrically-activated silver-based antibacterial surface system for medical device applications

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 24(3), 755–760.

By: M. Samberg n, Z. Tan*, N. Monteiro-Riviere n, P. Orndorff n & R. Shirwaiker*

Contributors: M. Samberg n, Z. Tan*, N. Monteiro-Riviere n, P. Orndorff n & R. Shirwaiker*

MeSH headings : Anti-Bacterial Agents; Biocompatible Materials; Equipment and Supplies; Escherichia coli / drug effects; Microbial Sensitivity Tests; Silver; Staphylococcus aureus / drug effects; Surface Properties
TL;DR: The study concluded that the technological applications of the surface system for medical devices and surgical tools, which contact human tissues for less than 1.5 h, are expected to be self-sterilizing without causing toxicity in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Computational approaches and metrics required for formulating biologically realistic nanomaterial pharmacokinetic models

Computational Science & Discovery, 6(1), 014005.

By: J. Riviere, C. Scoglio, F. Sahneh & N. Monteiro-Riviere*

Contributors: J. Riviere, C. Scoglio, F. Sahneh & N. Monteiro-Riviere*

Sources: Crossref, NC State University Libraries, ORCID
Added: June 12, 2021

2013 review

Nanomaterials and synergistic low-intensity direct current (LIDC) stimulation technology for orthopedic implantable medical devices

[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 5(3), 191–204.

By: R. Shirwaiker n, M. Samberg n, P. Cohen n, R. Wysk n & N. Monteiro-Riviere n

Contributors: R. Shirwaiker n, M. Samberg n, P. Cohen n, R. Wysk n & N. Monteiro-Riviere n

MeSH headings : Animals; Electric Stimulation / methods; Equipment and Supplies; Humans; Nanostructures / therapeutic use; Nanostructures / ultrastructure; Nanotechnology / methods; Orthopedics; Prostheses and Implants
TL;DR: While many nanomaterials have clearly demonstrated their ability to provide more effective implantable medical surfaces, further decisive investigations are necessary before they can translate into medically safe and commercially viable clinical applications. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Oxidative Stress and Dermal Toxicity of Iron Oxide Nanoparticles In Vitro

CELL BIOCHEMISTRY AND BIOPHYSICS, 67(2), 461–476.

By: A. Murray*, E. Kisin*, A. Inman n, S. Young*, M. Muhammed*, T. Burks*, A. Uheida*, A. Tkach* ...

Contributors: A. Murray*, E. Kisin*, A. Inman n, S. Young*, M. Muhammed*, T. Burks*, A. Uheida*, A. Tkach* ...

author keywords: Nanoparticles; Skin exposure; Ultraviolet radiation; Iron oxide
MeSH headings : Biological Transport; Cell Survival / drug effects; Cytokines / metabolism; Glutathione / metabolism; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; L-Lactate Dehydrogenase / metabolism; Magnetite Nanoparticles / chemistry; Magnetite Nanoparticles / toxicity; NF-kappa B / metabolism; Oxidative Stress / drug effects; Particle Size; Skin / cytology; Skin / drug effects; Transcription Factor AP-1 / metabolism
TL;DR: Data indicate that co-exposure to UVB and SPIONs was associated with induction of oxidative stress and release of inflammatory mediators, verifying the need to thoroughly evaluate the adverse effects of UVB when evaluating dermal toxicity of engineered NPs on skin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 review

Predicting skin permeability from complex vehicles

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 65(2), 265–277.

By: D. Karadzovska n, J. Brooks n, N. Monteiro-Riviere n & J. Riviere n

Contributors: D. Karadzovska n, J. Brooks n, N. Monteiro-Riviere n & J. Riviere n

author keywords: Chemical mixtures; Formulations; Percutaneous/dermal absorption; Quantitative structure-permeation relationship (QSPR); QSAR; Linear free energy relationships (LFER); Mixture factor; Topical drug delivery enhancers
MeSH headings : Animals; Drug Delivery Systems; Humans; Linear Energy Transfer; Models, Theoretical; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / metabolism; Pharmaceutical Vehicles / chemistry; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption
TL;DR: This review highlights the progress made in predicting skin permeability from complex vehicles by extending the use of quantitative structure-permeation relationship (QSPR) models based on linear free energy relationships (LFER) to predict dermal absorption from complex mixtures with the inclusion of significant molecular descriptors such as a mixture factor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Protein binding modulates the cellular uptake of silver nanoparticles into human cells: Implications for in vitro to in vivo extrapolations?

TOXICOLOGY LETTERS, 220(3), 286–293.

By: N. Monteiro-Riviere n, M. Samberg n, S. Oldenburg* & J. Riviere n

Contributors: N. Monteiro-Riviere n, M. Samberg n, S. Oldenburg* & J. Riviere n

author keywords: Protein corona; Protein binding of nanoparticles; Cellular uptake of silver nanoparticles; Albumin cell uptake; Transferrin cell uptake; IgG cell uptake
MeSH headings : Humans; Immunoglobulin G / metabolism; Keratinocytes / metabolism; Metal Nanoparticles / chemistry; Microscopy, Electron, Transmission; Protein Binding; Serum Albumin / metabolism; Silver / metabolism; Transferrin / metabolism
TL;DR: NP association with different serum proteins, purportedly forming different protein coronas, significantly modulates Ag uptake into HEK compared to native NP uptake, suggesting caution in extrapolating in vitro uptake data to predict behavior in vivo where the nature of the protein corona may determine patterns of cellular uptake, and thus biodistribution, biological activity and toxicity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 chapter

Skin Penetration of Engineered Nanomaterials

In E. A. Nasir, A. Friedman, & S. Wang (Eds.), Nanotechnology in Dermatology (Vol. 9781461450344, pp. 51–61).

By: N. Monteiro-Riviere*

Contributors: N. Monteiro-Riviere*

Ed(s): E. Nasir, A. Friedman & S. Wang

TL;DR: This chapter is to depict how skin can serve as a potential route of exposure to several types of nanomaterials, and will discuss how size, shape, charge, surface properties, and vehicles can be important determinants on the penetration through the rate-limiting lipid barrier of the stratum corneum. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: June 12, 2021

2013 journal article

The effects of geometry on skin penetration and failure of polymer microneedles

JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY, 27(3), 227–243.

By: S. Gittard n, B. Chen n, H. Xu n, A. Ovsianikov*, B. Chichkov*, N. Monteiro-Riviere n, R. Narayan n

Contributors: S. Gittard n, B. Chen n, H. Xu n, A. Ovsianikov*, B. Chichkov*, N. Monteiro-Riviere n, R. Narayan n

author keywords: microneedle; micromolding; acrylate-based polymer; porcine skin
TL;DR: Video captured during skin penetration revealed that microneedle penetration into the skin occurred by means of a series of insertions and not by Means of a single insertion event, shedding insight into the mechanisms of microneEDle penetration and failure, facilitating design improvements for polymer microneeds. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

Acute vascular effects of nanoparticle infusion in isolated perfused skin

Nanomedicine: Nanotechnology, Biology and Medicine, 8(4), 428–431.

By: J. Riviere n, T. Leavens n, J. Brooks n & N. Monteiro-Riviere n

Contributors: J. Riviere n, T. Leavens n, J. Brooks n & N. Monteiro-Riviere n

author keywords: Nanoparticles; Vascular toxicity; In vitro; Biodistribution
MeSH headings : Animals; Female; Perfusion; Quantum Dots; Skin / blood supply; Skin / pathology; Skin / physiopathology; Sus scrofa; Vascular Resistance / drug effects
TL;DR: Specific nanoparticle infusions were demonstrated to be associated with significant acute vascular physiological effects, and these observations suggest certain nanoparticles infusions may beassociated with acute vascular physiologic effects that merit further attention. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Challenges obtaining a biowaiver for topical veterinary dosage forms

Journal of Veterinary Pharmacology and Therapeutics, 35(SUPPL. 1), 103–114.

Contributors: R. Baynes n, J. Riviere n, T. Franz, N. Monteiro-Riviere n, P. Lehman, M. Peyrou*, P. Toutain*

MeSH headings : Administration, Topical; Animals; Dosage Forms; Drug Administration Routes; Legislation, Drug; Species Specificity; Therapeutic Equivalency; Veterinary Drugs / administration & dosage; Veterinary Drugs / chemistry; Veterinary Drugs / pharmacokinetics
TL;DR: The focus of this paper is to address several of the challenges associated with determining the BE of these locally acting drugs and critically examine the current technological advances that can act as a surrogate for clinical trials. (via Semantic Scholar)
Sources: ORCID, Web Of Science, Crossref
Added: August 6, 2018

2012 chapter

Effects of Engineered Nanomaterials on Skin

In B. Fadeel, A. Pietroiusti, & A. Shvedova (Eds.), Adverse Effects of Engineered Nanomaterials : Exposure, Toxicology, and Impact on Human Health (pp. 185–207). Burlington: Elsevier Science.

By: N. Monteiro Riviere & F. Larese Filon

Ed(s): B. Fadeel, A. Pietroiusti & A. Shvedova

Source: NC State University Libraries
Added: June 12, 2021

2012 journal article

Effects of eight nanoparticles of different sizes and shapes on human epidermal keratinocytes

Journal of Investigative Dermatology, 132, S52. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000302866900308&KeyUID=WOS:000302866900308

By: N. Monteiro-Riviere, A. Inman, S. Mathur, M. Muhammed, B. Fadeel & J. Riviere

Contributors: N. Monteiro-Riviere, A. Inman, S. Mathur, M. Muhammed, B. Fadeel & J. Riviere

Source: ORCID
Added: June 27, 2019

2012 chapter

In Vitro and In Vivo Toxicity of Silver Nanoparticles

In E. B. Bhushan) (Ed.), Encyclopedia of Nanotechnology (pp. 1069–1077,). Heidelberg, Germany: Springer Verlag.

By: M. Samberg & N. Monteiro-Riviere

Ed(s): E. Bhushan)

Source: NC State University Libraries
Added: June 12, 2021

2012 journal article

In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps

JOURNAL OF APPLIED TOXICOLOGY, 32(11), 913–919.

By: T. Leavens n, N. Monteiro-Riviere n, A. Inman n, J. Brooks n, S. Oldenburg* & J. Riviere n

Contributors: T. Leavens n, N. Monteiro-Riviere n, A. Inman n, J. Brooks n, S. Oldenburg* & J. Riviere n

author keywords: silver nanoparticles; biodistribution; skin
MeSH headings : Animals; Metal Nanoparticles / chemistry; Nanoparticles / chemistry; Perfusion; Silver / chemistry; Silver / pharmacokinetics; Skin / metabolism; Swine / metabolism; Tissue Distribution
TL;DR: The objective of the present study was to quantify the local biodistribution of two types of Ag nanoparticles, Ag‐citrate and Ag‐silica, in the isolated perfused porcine skin flap (IPPSF), and found no detectable elimination of Ag from the system. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

LACK OF HYDROXYLATED FULLERENE TOXICITY AFTER INTRAVENOUS ADMINISTRATION TO FEMALE SPRAGUE-DAWLEY RATS

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 75(7), 367–373.

By: N. Monteiro-Riviere n, K. Linder n, A. Inman n, J. Saathoff n, X. Xia n & J. Riviere n

Contributors: N. Monteiro-Riviere n, K. Linder n, A. Inman n, J. Saathoff n, X. Xia n & J. Riviere n

MeSH headings : Animals; Blood Chemical Analysis; Drug Administration Schedule; Female; Fullerenes / administration & dosage; Fullerenes / chemistry; Fullerenes / toxicity; Injections, Intravenous; Liver / drug effects; Lymphocytes / drug effects; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / toxicity; Rats; Rats, Sprague-Dawley; Thymus Gland / drug effects; Toxicity Tests, Acute; Urinalysis
TL;DR: These experiments suggest that this fullerol was well tolerated after iv administration to rats, and no clinically significant chemistry changes were observed after treatment. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Quantum dot penetration into viable human skin

NANOTOXICOLOGY, 6(2), 173–185.

By: T. Prow*, N. Monteiro-Riviere n, A. Inman n, J. Grice*, X. Chen*, X. Zhao*, W. Sanchez*, A. Gierden* ...

Contributors: T. Prow*, N. Monteiro-Riviere n, A. Inman n, J. Grice*, X. Chen*, X. Zhao*, W. Sanchez*, A. Gierden* ...

author keywords: Nanoparticles; exposure; nanotoxicology; surface chemistry
MeSH headings : Diffusion Chambers, Culture; Female; Humans; Hydrogen-Ion Concentration; Microscopy, Confocal; Nanoparticles; Particle Size; Polyethylene Glycols / metabolism; Polyethylene Glycols / pharmacology; Quantum Dots; Skin / chemistry; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Tissue Culture Techniques
TL;DR: Systematic studies probing the effects of nanoparticle surface modification and formulation pH are important in nanotoxicology and nanomedicine and this study uses laser-scanning fluorescence confocal microscopy to evaluate nanoparticle penetration in viable excised human skin that was intact or tape-stripped. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Silver nanoparticles do not influence stem cell differentiation but cause minimal toxicity

NANOMEDICINE, 7(8), 1197–1209.

By: M. Samberg n, E. Loboa n, S. Oldenburg* & N. Monteiro-Riviere n

Contributors: M. Samberg n, E. Loboa n, S. Oldenburg* & N. Monteiro-Riviere n

author keywords: in vitro; nanoparticles; nanotechnology; nanotoxicology; scaffolds; silver; stem cells
MeSH headings : Adipose Tissue / cytology; Adult; Cell Differentiation / drug effects; Cell Survival / drug effects; Cells, Cultured; Female; Humans; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Silver / toxicity; Stem Cells / cytology; Stem Cells / drug effects; Young Adult
TL;DR: The biocompatibility of Ag-NPs with both undifferentiated and differentiated hASC establishes their suitability for incorporation into tissue-engineered graft scaffolds, for the prevention of bacterial contamination upon implantation. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 chapter

Skin

In Adverse Effects of Engineered Nanomaterials (pp. 185–207).

By: N. Monteiro-Riviere n & F. Filon*

Contributors: N. Monteiro-Riviere n & F. Filon*

UN Sustainable Development Goal Categories
Source: ORCID
Added: September 25, 2022

2012 journal article

Ultrananocrystalline Diamond-Coated Microporous Silicon Nitride Membranes for Medical Implant Applications

JOM, 64(4), 520–525.

By: S. Skoog n, A. Sumant*, N. Monteiro-Riviere n & R. Narayan n

Contributors: S. Skoog n, A. Sumant*, N. Monteiro-Riviere n & R. Narayan n

TL;DR: The results show that the UNCD coating did not significantly alter the viability of human epidermal keratinocytes, indicating potential use of this material for improving skin sealing around percutaneous implants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Use of confocal microscopy for nanoparticle drug delivery through skin

Journal of Biomedical Optics, 18(6), 061214.

By: L. Zhang* & N. Monteiro-Riviere*

Contributors: L. Zhang* & N. Monteiro-Riviere*

author keywords: nanoparticles; confocal laser scanning microscopy; skin; keratinocytes
MeSH headings : Animals; Cell Line; Dendritic Cells / chemistry; Dendritic Cells / metabolism; Hair Follicle / chemistry; Hair Follicle / metabolism; Humans; Keratinocytes / chemistry; Keratinocytes / metabolism; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Microscopy, Confocal / methods; Quantum Dots; Silver / chemistry; Skin / chemistry; Skin / cytology; Skin / metabolism; Skin Absorption / drug effects; Skin Absorption / physiology; Swine
TL;DR: The unique functions of CLSM such as the ability to detect fluorescence, optical sectioning, three dimensional remodeling, as well as its use in the reflection mode in tandem with other methods, provides great promise with broad applications regarding the interactions of nanomaterials with skin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: May 30, 2021

2012 journal article

Zinc oxide - nanosize does not change the toxicological profile

Naunyn-Schmiedebergs Archives of Pharmacology, 385, 104. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000300779500460&KeyUID=WOS:000300779500460

By: K. Wiench, S. Schulte, S. Schneider, M. Lan, B. Ravenzwaay, N. Monteiro-Riviere, O. Creutzenberg, R. Landsiedel

Contributors: K. Wiench, S. Schulte, S. Schneider, M. Lan, B. Ravenzwaay, N. Monteiro-Riviere, O. Creutzenberg, R. Landsiedel

Source: ORCID
Added: June 27, 2019

2011 journal article

Antibacterial efficacy of silver nanoparticles of different sizes, surface conditions and synthesis methods

NANOTOXICOLOGY, 5(2), 244–253.

By: M. Samberg n, P. Orndorff n & N. Monteiro-Riviere n

Contributors: M. Samberg n, P. Orndorff n & N. Monteiro-Riviere n

author keywords: Silver; nanoparticles; nanotechnology; nanotoxicity; microbiology
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Escherichia coli / drug effects; Humans; Materials Testing; Metal Nanoparticles / chemistry; Metal Nanoparticles / ultrastructure; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Particle Size; Silver / chemistry; Silver / pharmacology; Staphylococcus aureus / drug effects; Surface Properties
TL;DR: Silver nanoparticles are used as a natural biocide to prevent undesired bacterial growth in clothing and cosmetics to assess the antibacterial efficacy of Ag-nps of different sizes, surface conditions, and synthesis methods against Escherichia coli, Ag-resistant E. coli, methicillin-resistant S. aureus, and Salmonella sp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Atomic layer deposition of titanium dioxide on cellulose acetate for enhanced hemostasis

Biotechnology Journal, 6(2), 213–223.

By: G. Hyde n, S. Stewart n, G. Scarel n, G. Parsons n, C. Shih*, C. Shih*, S. Lin*, Y. Su* ...

Contributors: G. Hyde n, S. Stewart n, G. Scarel n, G. Parsons n, C. Shih*, C. Shih*, S. Lin*, Y. Su*, N. Monteiro-Riviere n, R. Narayan n

author keywords: Biomaterials; Cellulose; Hemocompatibility; Hemostatic agent; Titanium oxide
MeSH headings : Cell Survival / physiology; Cellulose / analogs & derivatives; Cellulose / chemistry; Cellulose / pharmacology; Hemostasis / drug effects; Humans; Microscopy, Electron, Scanning; Platelet-Rich Plasma / drug effects; Spectroscopy, Fourier Transform Infrared; Titanium / chemistry; Wettability
TL;DR: The results suggest that atomic layer deposition is an appropriate method for improving the biological properties of hemostatic agents and other blood-contacting biomaterials. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

Cellular uptake mechanisms and toxicity of quantum dots in dendritic cells

NANOMEDICINE, 6(5), 777–791.

By: L. Zhang n, W. Baeumer & N. Monteiro-Riviere*

Contributors: L. Zhang n, W. Baeumer & N. Monteiro-Riviere*

author keywords: cellular uptake; dendritic cells; endocytosis; LPS; nanoparticles; quantum dot nanoparticles; scavenger receptor
MeSH headings : Animals; B7-1 Antigen / immunology; B7-2 Antigen / immunology; Cell Differentiation; Cell Survival; Cells, Cultured; Dendritic Cells / cytology; Dendritic Cells / immunology; Endocytosis; Granulocyte-Macrophage Colony-Stimulating Factor / immunology; Lipopolysaccharides / immunology; Monocytes / cytology; Monocytes / immunology; Quantum Dots; Swine
TL;DR: Light is shed on the mechanism of QD655-COOH uptake in DCs and that cellular uptake pathways are dependent on cell type and cell differentiation, suggesting suppression with DC maturation. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 article

Commentary on transcutaneous delivery

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, Vol. 3, pp. 439–440.

By: N. Monteiro-Riviere n

Contributors: N. Monteiro-Riviere n

TL;DR: The article by Bolzinger, Briançon, and Chevalier in this issue of WIREs Nanomedicine and Nanobiotechnology focuses on addressing the apparent discrepancies in skin penetration of inorganic and organic nanoparticles used in cosmetics and pharmaceutical applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Deposition of antimicrobial coatings on microstereolithography-fabricated microneedles

JOM, 63(6), 59–68.

By: S. Gittard n, P. Miller n, C. Jin n, T. Martin n, R. Boehm n, B. Chisholm*, S. Stafslien*, J. Daniels* ...

Contributors: S. Gittard n, P. Miller n, C. Jin n, T. Martin n, R. Boehm n, B. Chisholm*, S. Stafslien*, J. Daniels* ...

TL;DR: It is indicated that light-based technologies, including visible light dynamic mask microstereolithography and pulsed laser deposition, may be used to fabricate microneedles with antimicrobial properties for treatment of local skin infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Dermal Penetration of UVB-Damaged Skin by Titanium- and Zincoxide Nanoparticles in Sunscreen Formulations

Naunyn-Schmiedebergs Archives of Pharmacology, 383, 101. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000288573100511&KeyUID=WOS:000288573100511

By: N. Monteiro-Riviere, J. Riviere, A. Inman, K. Wiench, S. Schulte & R. Landsiedel

Contributors: N. Monteiro-Riviere, J. Riviere, A. Inman, K. Wiench, S. Schulte & R. Landsiedel

Source: ORCID
Added: June 27, 2019

2011 journal article

In vitro toxicity assessment of three hydroxylated fullerenes in human skin cells

TOXICOLOGY IN VITRO, 25(8), 2105–2112.

By: J. Saathoff n, A. Inman n, X. Xia n, J. Riviere n & N. Monteiro-Riviere n

Contributors: J. Saathoff n, A. Inman n, X. Xia n, J. Riviere n & N. Monteiro-Riviere n

author keywords: Hydroxylated fullerenes; Fullerenes; Cytotoxicity; Skin cells; Keratinocytes; Nanoparticles
MeSH headings : Biological Transport; Cell Survival; Cells, Cultured; Fullerenes / chemistry; Fullerenes / metabolism; Fullerenes / toxicity; Humans; Hydroxylation; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / ultrastructure; Microscopy, Electron, Transmission; Photoelectron Spectroscopy; Spectrometry, Fluorescence
TL;DR: Results suggest that different hydroxylation of fullerenes caused no cytotoxicity or inflammation up to 8.55 μg/ml, and suggest that extrapolation across similar NP will be dependent upon surface chemistry and concentration which may affect the degree of agglomeration and thus biological effects. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing

Biomicrofluidics, 5(1), 013415.

By: P. Miller n, S. Gittard n, T. Edwards n, D. Lopez n, X. Xiao n, D. Wheeler n, N. Monteiro-Riviere n, S. Brozik n, R. Polsky n, R. Narayan n

Contributors: P. Miller n, S. Gittard n, T. Edwards n, D. Lopez n, X. Xiao n, D. Wheeler n, N. Monteiro-Riviere n, S. Brozik n, R. Polsky n, R. Narayan n

TL;DR: Carbon fiber electrodes were incorporated within a hollow microneedle array, which was fabricated using a digital micromirror device-based stereolithography instrument, and electrochemical measurements were demonstrated using integrated electrode-hollow micronedle devices. (via Semantic Scholar)
Sources: ORCID, Web Of Science, Crossref
Added: August 6, 2018

2011 journal article

Mapping the Surface Adsorption Forces of Nanomaterials in Biological Systems

ACS NANO, 5(11), 9074–9081.

By: X. Xia n, N. Monteiro-Riviere n, S. Mathur*, X. Song*, L. Xiao*, S. Oldenberg*, B. Fadeel*, J. Riviere n

Contributors: X. Xia n, N. Monteiro-Riviere n, S. Mathur*, X. Song*, L. Xiao*, S. Oldenberg*, B. Fadeel*, J. Riviere n

author keywords: engineered nanomaterials; surface adsorption; risk assessment; nanotoxicology; nanomedicine; nanomaterial characterization
MeSH headings : Adsorption; Biology; Nanostructures / chemistry; Surface Properties
TL;DR: The BSAI nanodescriptors are intrinsic properties of nanomaterials useful for quantitative structure-activity relationship (QSAR) model development and could open a quantitative avenue in predictive nanomedicine development, risk assessment, and safety evaluation of nanmaterials. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Modification of microneedles using inkjet printing

AIP Advances, 1(2), 022139.

By: R. Boehm n, P. Miller n, S. Hayes n, N. Monteiro-Riviere n & R. Narayan n

Contributors: R. Boehm n, P. Miller n, S. Hayes n, N. Monteiro-Riviere n & R. Narayan n

TL;DR: The results suggest that the combination of visible light dynamic mask micro-stereolithography-micromolding and inkjet printing enables fabrication of solid biodegradable microneedles with a widerange of geometries as well as a wide range of pharmacologic agent compositions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles

FARADAY DISCUSSIONS, 149, 171–185.

By: S. Gittard n, P. Miller n, R. Boehm n, A. Ovsianikov*, B. Chichkov*, J. Heiser*, J. Gordon*, N. Monteiro-Riviere n, R. Narayan n

Contributors: S. Gittard n, P. Miller n, R. Boehm n, A. Ovsianikov*, B. Chichkov*, J. Heiser*, J. Gordon*, N. Monteiro-Riviere n, R. Narayan n

MeSH headings : Administration, Cutaneous; Animals; Drug Delivery Systems / instrumentation; Female; Humans; Infant, Newborn; Keratinocytes / chemistry; Microinjections / methods; Microscopy, Fluorescence; Needles; Polymers / chemistry; Quantum Dots; Skin / chemistry; Skin / cytology; Swine
TL;DR: In this study, microneedle devices for transdermal drug delivery were fabricated by means of two-photon polymerization of an acrylate-based polymer to examine proliferation of cells on this polymer using neonatal human epidermal keratinocytes and human dermal fibroblasts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Safety Evaluation of Sunscreen Formulations Containing Titanium Dioxide and Zinc Oxide Nanoparticles in UVB Sunburned Skin: An In Vitro and In Vivo Study

TOXICOLOGICAL SCIENCES, 123(1), 264–280.

By: N. Monteiro-Riviere n, K. Wiench*, R. Landsiedel*, S. Schulte*, A. Inman n & J. Riviere n

Contributors: N. Monteiro-Riviere n, K. Wiench*, R. Landsiedel*, S. Schulte*, A. Inman n & J. Riviere n

author keywords: sunscreens; sunburn skin; titanium dioxide (TiO2); zinc oxide (ZnO); nanoparticles; skin penetration
MeSH headings : Animals; Erythema / etiology; Erythema / pathology; Erythema / prevention & control; In Vitro Techniques; Metal Nanoparticles / radiation effects; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Particle Size; Skin / drug effects; Skin / pathology; Skin / radiation effects; Skin / ultrastructure; Sunburn / drug therapy; Sunburn / etiology; Sunburn / pathology; Sunscreening Agents / pharmacokinetics; Sunscreening Agents / toxicity; Swine / physiology; Titanium / pharmacokinetics; Titanium / radiation effects; Titanium / toxicity; Ultraviolet Rays / adverse effects; Zinc Oxide / pharmacokinetics; Zinc Oxide / radiation effects; Zinc Oxide / toxicity
TL;DR: UVB-damaged skin slightly enhanced TiO(2) NP or ZnO NP penetration in sunscreen formulations but no transdermal absorption was detected. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 chapter

Absorption, Penetration, and Cutaneous Toxicity of Jet Fuels and Hydrocarbon Components

In Jet Fuel Toxicology (pp. 119–134).

By: J. Riviere, A. Inman & N. Monteiro-Riviere*

Sources: Crossref, NC State University Libraries
Added: June 12, 2021

2010 chapter

Absorption, penetration, and cutaneous toxicity of jet fuels and hydrocarbon components

In Jet Fuel Toxicology (pp. 119–134).

By: J. Riviere, A. Inman & N. Monteiro-Riviere

Contributors: J. Riviere, A. Inman & N. Monteiro-Riviere

Source: ORCID
Added: September 25, 2022

2010 journal article

An index for characterization of nanomaterials in biological systems

Nature Nanotechnology, 5(9), 671–675.

By: X. Xia n, N. Monteiro-Riviere n & J. Riviere n

Contributors: X. Xia n, N. Monteiro-Riviere n & J. Riviere n

MeSH headings : Adsorption; Hormones / chemistry; Models, Chemical; Nanostructures / chemistry; Nanotubes, Carbon / chemistry; Proteins / chemistry; Small Molecule Libraries / chemistry; Steroids / chemistry
TL;DR: The method successfully predicted the adsorption of various small molecules onto carbon nanotubes, and the nanodescriptors can be used to develop pharmacokinetic and safety assessment models for nanomaterials. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2010 journal article

Atomic layer deposition of nanoporous biomaterials

MATERIALS TODAY, 13(3), 60–64.

By: R. Narayan n, S. Adiga*, M. Pellin*, L. Curtiss*, S. Stafslien*, B. Chisholm*, N. Monteiro-Riviere n, R. Brigmon*, J. Elam*

Contributors: R. Narayan n, S. Adiga*, M. Pellin*, L. Curtiss*, S. Stafslien*, B. Chisholm*, N. Monteiro-Riviere n, R. Brigmon*, J. Elam*

TL;DR: The results suggest that atomic layer deposition is an attractive technique for modifying the surfaces of nanoporous alumina membranes and other nanostructured biomaterials. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Atomic layer deposition-based functionalization of materials for medical and environmental health applications

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 368(1917), 2033–2064.

By: R. Narayan n, S. Adiga*, M. Pellin*, L. Curtiss*, A. Hryn*, S. Stafslien*, B. Chisholm*, C. Shih* ...

Contributors: R. Narayan n, S. Adiga*, M. Pellin*, L. Curtiss*, A. Hryn*, S. Stafslien*, B. Chisholm*, C. Shih* ...

author keywords: atomic layer deposition; self-assembly; nanoporous alumina; antimicrobial; antifouling
MeSH headings : Adsorption; Aluminum Oxide / chemistry; Anti-Bacterial Agents / chemistry; Blood Platelets / metabolism; Coated Materials, Biocompatible / chemistry; Equipment Design; Escherichia coli / metabolism; Humans; Materials Testing; Nanostructures / chemistry; Nanotechnology / methods; Platinum / chemistry; Polyethylene Glycols / chemistry; Staphylococcus aureus / metabolism; Zinc Oxide / chemistry
TL;DR: The results of this work indicate that nanoporous alumina membranes may be modified using atomic layer deposition for use in a variety of medical and environmental health applications. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

CYTOKINE AND CHEMOKINE LEVELS IN SERUM AND CEREBROSPINAL FLUID OF DOGS WITH INFLAMMATORY CENTRAL NERVOUS SYSTEM DISEASE

Journal of Veterinary Internal Medicine, 24(3), 741. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000277416600262&KeyUID=WOS:000277416600262

By: C. Mariani, L. Boozer, G. Cherubini, K. Vernau, J. Campbell, S. Dillard, P. Early, R. Gallagher ...

Contributors: C. Mariani, L. Boozer, G. Cherubini, K. Vernau, J. Campbell, S. Dillard, P. Early, R. Gallagher ...

Source: ORCID
Added: June 27, 2019

2010 chapter

Characterization of Toxicoproteomics Maps for Chemical Mixtures Using Information Theoretic Approach

In Principles and Practice of Mixtures Toxicology (pp. 215–234).

By: S. Basak*, B. Gute*, N. Monteiro-Riviere n & F. Witzmann*

Contributors: S. Basak*, B. Gute*, N. Monteiro-Riviere n & F. Witzmann*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 30, 2021

2010 chapter

Dermal Exposure and Absorption of Chemicals and Nanomaterials*

In Comprehensive Toxicology (Vol. 1-14, pp. 111–122).

By: J. Riviere n & N. Monteiro-Riviere n

Contributors: J. Riviere n & N. Monteiro-Riviere n

TL;DR: Techniques for quantitating skin permeability using this assumption and basic approaches to linking permeability to molecular properties using quantitative structure permeability relationships (QSPeR) are presented. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 30, 2021

2010 journal article

EVALUATION OF CYTOKINE AND CHEMOKINE LEVELS IN CANINE INTRACRANIAL NEOPLASIA

Journal of Veterinary Internal Medicine, 24(3), 741. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000277416600264&KeyUID=WOS:000277416600264

By: L. Boozer, C. Mariani, J. Campbell, S. Dillard, P. Early, R. Gallagher, E. MacKillop, K. Munana ...

Contributors: L. Boozer, C. Mariani, J. Campbell, S. Dillard, P. Early, R. Gallagher, E. MacKillop, K. Munana ...

Source: ORCID
Added: June 27, 2019

2010 chapter

Evaluating the risks associated with nanomaterials

In E. A. V. Narlikar & Y. Y. Du (Eds.), The Oxford Handbook of Nanoscience and Technology, Frontiers and Advances: Vol. III (pp. 888–906,). Oxford: Oxford University Press.

By: K. Thomas, N. Monteiro-Riviere, D. Warheit & N. Savage

Ed(s): E. Narlikar & Y. Du

Source: NC State University Libraries
Added: June 12, 2021

2010 journal article

Evaluation of Silver Nanoparticle Toxicity in Skin in Vivo and Keratinocytes in Vitro

ENVIRONMENTAL HEALTH PERSPECTIVES, 118(3), 407–413.

By: M. Samberg n, S. Oldenburg* & N. Monteiro-Riviere n

Contributors: M. Samberg n, S. Oldenburg* & N. Monteiro-Riviere n

author keywords: keratinocytes; metal oxides; nanoparticles; nanotechnology; porcine skin; silver; skin penetration; toxicity
MeSH headings : Animals; Cell Survival / drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Humans; Inflammation / chemically induced; Inflammation / metabolism; Inflammation / pathology; Interleukins / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / toxicity; Particle Size; Silver / administration & dosage; Silver / toxicity; Skin / cytology; Skin / drug effects; Skin / metabolism; Swine; Time Factors; Tumor Necrosis Factor-alpha / metabolism
TL;DR: A better understanding of Ag-nps safety in vitro as well as in vivo is provided and a basis for occupational and risk assessment. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles

TOXICOLOGY LETTERS, 197(1), 1–6.

By: T. Leavens n, X. Xia n, H. Lee n, N. Monteiro-Riviere n, J. Brooks n & J. Riviere n

Contributors: T. Leavens n, X. Xia n, H. Lee n, N. Monteiro-Riviere n, J. Brooks n & J. Riviere n

author keywords: nC(60); Isolated perfused porcine skin flaps; Pharmacokinetics; In vitro; Nanoparticles; Skin
MeSH headings : Animals; Arteries / metabolism; Colloids; Female; Fullerenes / pharmacokinetics; Immunoglobulin G / metabolism; Models, Animal; Nanoparticles / ultrastructure; Skin / metabolism; Swine; Tissue Distribution; Veins / metabolism
TL;DR: Based on the apparent volume of distribution, the low extraction during the perfusion, and the high percentage recovery following the washout phase, there was limited distribution of fullerene nanoparticles from the vascular space into the extracellular space and negligible intracellular uptake of nC(60) in this system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Fabrication of Microneedles Using Two Photon Polymerization for Transdermal Delivery of Nanomaterials

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 10(10), 6305–6312.

By: A. Doraiswamy n, A. Ovsianikov, S. Gittard*, N. Monteiro-Riviere*, R. Crombez, E. Montalvo, W. Shen, B. Chichkov, R. Narayan*

Contributors: A. Doraiswamy n, A. Ovsianikov, S. Gittard*, N. Monteiro-Riviere*, R. Crombez, E. Montalvo, W. Shen, B. Chichkov, R. Narayan*

author keywords: Microneedle; Transdermal Drug Delivery; Rapid Prototyping; Nanomaterials; Human Epidermal Keratinocytes
MeSH headings : Administration, Cutaneous; Animals; Biocompatible Materials / administration & dosage; Biocompatible Materials / chemistry; Cell Survival / drug effects; Cells, Cultured; Drug Delivery Systems / instrumentation; Elastic Modulus; Equipment Design; Female; Hardness; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Materials Testing; Microscopy, Confocal; Microscopy, Electron, Scanning; Microtechnology / methods; Nanostructures / administration & dosage; Needles; Polymerization; Quantum Dots; Skin / drug effects; Skin / metabolism; Swine
TL;DR: Microneedies were shown to enable more rapid distribution of the PEG-amine quantum dot solution to the deep epidermis and dermis layers of porcine skin than topical administration and suggest that two photon polymerization may be used to create microneedle arrays for transdermal delivery of nanoscale pharmacologic agents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

In vitro biocompatibility of titanium alloy discs made using direct metal fabrication

MEDICAL ENGINEERING & PHYSICS, 32(6), 645–652.

By: C. Haslauer n, J. Springer n, O. Harrysson n, E. Loboa n, N. Monteiro-Riviere n & D. Marcellin-Little n

Contributors: C. Haslauer n, J. Springer n, O. Harrysson n, E. Loboa n, N. Monteiro-Riviere n & D. Marcellin-Little n

author keywords: Biocompatibility; Orthopedic implant; Free-form fabrication; Direct metal fabrication; Electron beam melting; Stem cell; Human stem cell
MeSH headings : Adipose Tissue / cytology; Alloys / chemical synthesis; Alloys / chemistry; Alloys / pharmacology; Aluminum / chemistry; Cell Proliferation / drug effects; Cell Survival / drug effects; Female; Humans; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Materials Testing / methods; Middle Aged; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / metabolism; Surface Properties; Titanium / chemistry; Titanium / pharmacology; Vanadium / chemistry
TL;DR: In vitro biocompatibility of EBM titanium-6 aluminum-4 vanadium (Ti6Al4V) structures is assessed by comparing the cellular response to solid polished, solid unpolished, and porous EBM discs to the Cellular response to discs made of commercially produced Ti6Al 4V. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Interactions of aluminum nanoparticles with human epidermal keratinocytes

JOURNAL OF APPLIED TOXICOLOGY, 30(3), 276–285.

By: N. Monteiro-Riviere n, S. Oldenburg* & A. Inman n

Contributors: N. Monteiro-Riviere n, S. Oldenburg* & A. Inman n

author keywords: aluminum; nanoparticles; human epidermal keratinocytes; nanotoxicity; viability assays; cytokine
MeSH headings : Aluminum / analysis; Aluminum / chemistry; Aluminum / toxicity; Artifacts; Cell Survival / drug effects; Cells, Cultured; Humans; Indicators and Reagents / chemistry; Inflammation Mediators / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / ultrastructure; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Microscopy, Electron, Transmission; Osmolar Concentration; Particle Size; Reproducibility of Results; Spectrophotometry; Temperature; Vacuoles / ultrastructure
TL;DR: The difficulties involved in assessing the biological safety of nanomaterials such as Al NP due to media‐ and temperature‐dependent particle agglomeration and nanoparticle interactions with biomarkers of cytotoxicity are illustrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Intrinsic biological property of colloidal fullerene nanoparticles (nC(60)): Lack of lethality after high dose exposure to human epidermal and bacterial cells

TOXICOLOGY LETTERS, 197(2), 128–134.

By: X. Xia n, N. Monteiro-Riviere n & J. Riviere n

Contributors: X. Xia n, N. Monteiro-Riviere n & J. Riviere n

author keywords: Water-soluble fullerenes; Nanotoxicity; Fullerene nanoparticles; Bacteria toxicity; Human epidermal keratinocytes
MeSH headings : Bacillus subtilis / drug effects; Epidermal Cells; Escherichia coli / drug effects; Fullerenes / chemistry; Fullerenes / toxicity; Humans; Keratinocytes / drug effects; Microbial Sensitivity Tests; Nanoparticles / chemistry; Nanoparticles / toxicity; Particle Size; Toxicity Tests
TL;DR: A novel method for preparing nC60 nanoparticles that does not use THF solvent, but provides nC 60 with an average particle size of 43.8 nm and a yield approximately 100 times higher than the THF method is reported, confirming the prior non-toxic reports when using nC50 prepared with non-THF methods. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Lectins modulate multi-walled carbon nanotubes cellular uptake in human epidermal keratinocytes

TOXICOLOGY IN VITRO, 24(2), 546–551.

By: L. Zhang n & N. Monteiro-Riviere n

Contributors: L. Zhang n & N. Monteiro-Riviere n

author keywords: Nanomaterials; Multi-walled carbon nanotubes; Lectins; Endocytic pathways; Melanosome transfer pathway; Cellular uptake
MeSH headings : Epidermal Cells; Humans; Keratinocytes / drug effects; Keratinocytes / metabolism; Lotus / chemistry; Solanum lycopersicum / chemistry; Microscopy, Electron, Transmission; Nanotubes, Carbon / ultrastructure; Peas / chemistry; Plant Lectins / pharmacology
TL;DR: Lectins are inhibitors of the melanosome transfer pathway was used to study the uptake of MWCNT in keratinocytes, to see if they played a role in reducing the cellular uptake of carbon nanotubes in HEK, and studies confirmed that lectin cocktails decreased M WCNT interaction at the cell surface and uptake. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 chapter

Nanomaterial penetration

In Toxicology of the Skin (pp. 333–346). http://www.scopus.com/inward/record.url?eid=2-s2.0-77958477177&partnerID=MN8TOARS

By: N. Monteiro-Riviere & B. Baroli

Contributors: N. Monteiro-Riviere & B. Baroli

Source: ORCID
Added: September 25, 2022

2010 chapter

Nanomaterials Penetration

In N. A. Monteiro-Riviere (Ed.), Toxicology of the Skin (pp. 333–346). New York, NY: Informa Healthcare.

By: N. Monteiro Riviere & B. Baroli

Ed(s): N. Monteiro-Riviere

Source: NC State University Libraries
Added: June 12, 2021

2010 chapter

Potential Arsenic Exposure Through Dermal Penetration

In N. A. Monteiro-Riviere) (Ed.), Toxicology of the Skin (pp. 347–360). http://www.scopus.com/inward/record.url?eid=2-s2.0-85056392662&partnerID=MN8TOARS

By: R. Grissom, C. Abernathy & N. Monteiro-Riviere

Contributors: R. Grissom, C. Abernathy & N. Monteiro-Riviere

Ed(s): N. Monteiro-Riviere)

Sources: NC State University Libraries, ORCID
Added: June 12, 2021

2010 book

Preface

In Toxicology of the Skin (p. v). http://www.scopus.com/inward/record.url?eid=2-s2.0-85060190964&partnerID=MN8TOARS

By: N. Monteiro-Riviere

Contributors: N. Monteiro-Riviere

Source: ORCID
Added: September 25, 2022

2010 journal article

Skin penetration and kinetics of pristine fullerenes (C-60) topically exposed in industrial organic solvents

TOXICOLOGY AND APPLIED PHARMACOLOGY, 242(1), 29–37.

By: X. Xia n, N. Monteiro-Riviere n & J. Riviere n

Contributors: X. Xia n, N. Monteiro-Riviere n & J. Riviere n

author keywords: Dermal absorption; Stratum corneum; Nanomaterials; Fullerenes; Solvent effects; Nanotoxicity
MeSH headings : Algorithms; Animals; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Fullerenes / pharmacokinetics; Fullerenes / toxicity; Occupational Exposure / adverse effects; Particle Size; Skin / chemistry; Skin / pathology; Skin Absorption; Solvents / chemistry; Swine
TL;DR: The solvent effects on the stratum corneum absorption of C60 were consistent with those observed in vivo; in vitro flow-through diffusion cell experiments were conducted in pig skin and fullerenes were not detected in the receptor solutions by 24 h. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 chapter

Structure and Function of Skin

In N. A. Monteiro-Riviere (Ed.), Toxicology of the Skin (pp. 1–18,). http://www.scopus.com/inward/record.url?eid=2-s2.0-85056380325&partnerID=MN8TOARS

By: N. Monteiro-Riviere

Contributors: N. Monteiro-Riviere

Ed(s): N. Monteiro-Riviere

Sources: NC State University Libraries, ORCID
Added: June 12, 2021

2010 book

Toxicology of the skin

New York, NY: Informa Healthcare.

Nancy Monteiro-Riviere

Ed(s): N. Monteiro-Riviere

Source: NC State University Libraries
Added: June 12, 2021

2010 book

Toxicology of the skin

In Toxicology of the Skin (pp. 1–437). http://www.scopus.com/inward/record.url?eid=2-s2.0-84868687035&partnerID=MN8TOARS

By: N. Monteiro-Riviere

Contributors: N. Monteiro-Riviere

Source: ORCID
Added: September 25, 2022

2010 journal article

Two Photon Polymerization-Micromolding of Polyethylene Glycol-Gentamicin Sulfate Microneedles

ADVANCED ENGINEERING MATERIALS, 12(4), B77–B82.

By: S. Gittard n, A. Ovsianikov*, H. Akar*, B. Chichkov*, N. Monteiro-Riviere n, S. Stafslien*, B. Chisholm*, C. Shin* ...

Contributors: S. Gittard n, A. Ovsianikov*, H. Akar*, B. Chichkov*, N. Monteiro-Riviere n, S. Stafslien*, B. Chisholm*, C. Shin* ...

TL;DR: In this study, a photopolymerization‐micromolding technique was used to fabricate microneedle arrays from a photosensitive material containing polyethylene glycol 600 diacrylate, gentamicin sulfate, and a photoinitiator that inhibited growth of Staphylococcus aureus bacteria. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

ASSESSMENT OF QUANTUM DOT PENETRATION INTO SKIN IN DIFFERENT SPECIES UNDER DIFFERENT MECHANICAL ACTIONS

Nanomaterials: Risks and Benefits, 43–52.

By: N. Monteiro-Riviere n, L. Zhang n, I. Linkov & J. Steevens

Contributors: N. Monteiro-Riviere n, L. Zhang n, I. Linkov & J. Steevens

TL;DR: Results indicate that porcine skin penetration of QD621 is minimal and limited primarily to the outer SC layers, while QD565 and 655 penetrated into the dermis of abraded skin and skin is an important organ and can serve as a potential route of exposure and should be overlooked. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: June 27, 2019

2009 journal article

Assessing the antimicrobial activity of zinc oxide thin films using disk diffusion and biofilm reactor

APPLIED SURFACE SCIENCE, 255(11), 5806–5811.

By: S. Gittard n, J. Perfect*, N. Monteiro-Riviere n, W. Wei n, C. Jin n & R. Narayan n

Contributors: S. Gittard n, J. Perfect*, N. Monteiro-Riviere n, W. Wei n, C. Jin n & R. Narayan n

author keywords: Antimicrobial materials; Pulsed laser deposition; Zinc oxide
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Atomic layer deposition of TiO2 thin films on nanoporous alumina templates: Medical applications

JOM, 61(6), 12–16.

By: R. Narayan n, N. Monteiro-Riviere n, R. Brigmon*, M. Pellin* & J. Elam*

Contributors: R. Narayan n, N. Monteiro-Riviere n, R. Brigmon*, M. Pellin* & J. Elam*

TL;DR: Atomic layer deposition was used to coat all the surfaces of a nanoporous alumina membrane in order to reduce the pore size in a controlled manner, and neither the 20 nm nor the 100 nm TiO2-coated nanoporus alumina membranes exhibited statistically lower viability compared to the uncoated nano-structure-based membrane control materials. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Comparison of Quantum Dot Biodistribution with a Blood-Flow-Limited Physiologically Based Pharmacokinetic Model

Nano Letters, 9(2), 794–799.

By: H. Lee n, T. Leavens n, S. Mason n, N. Monteiro-Riviere n & J. Riviere n

Contributors: H. Lee n, T. Leavens n, S. Mason n, N. Monteiro-Riviere n & J. Riviere n

MeSH headings : Animals; Hemodynamics; Mice; Models, Biological; Organ Specificity; Pharmacokinetics; Quantum Dots; Rats; Tissue Distribution
TL;DR: The physiologically based pharmacokinetic model predicted the experimentally observed persistence of QDs in tissues but not early time profiles or different QD biodistribution, suggesting more complex models will be needed to better predict QD biodiversity in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2009 journal article

Comparison of quantum dot biodistribution with a blood-flow-limited physiologically based pharmacokinetic model

Nano Letters, 9(2), 794–799.

By: H. Lee, T. Leavens, S. Mason, N. Monteiro-Riviere & J. Riviere

Contributors: H. Lee, T. Leavens, S. Mason, N. Monteiro-Riviere & J. Riviere

Source: ORCID
Added: September 25, 2022

2009 entry reference

Cutaneous Toxicology

By: J. Riviere n & N. Monteiro-Riviere n

Sources: Crossref, NC State University Libraries
Added: May 30, 2021

2009 journal article

Endocytic mechanisms and toxicity of a functionalized fullerene in human cells

TOXICOLOGY LETTERS, 191(2-3), 149–157.

By: L. Zhang n, J. Yang*, A. Barron* & N. Monteiro-Riviere n

Contributors: L. Zhang n, J. Yang*, A. Barron* & N. Monteiro-Riviere n

author keywords: Derivatized fullerene; Endocytosis; Cytotoxicity; Human epidermal keratinocytes; Cellular uptake; Nanoparticle
MeSH headings : Adenosine Triphosphate / metabolism; Cell Line; Cell Proliferation / drug effects; Cell Survival / drug effects; Coloring Agents; Drug Delivery Systems; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Fullerenes / chemistry; Fullerenes / toxicity; Humans; Lysosomes / drug effects; Microscopy, Confocal; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Models, Molecular; Spectrophotometry, Ultraviolet; Tetrazolium Salts; Thiazoles
TL;DR: Results showed that the endocytic pathways could be mediated by caveolae/lipid rafts and cytoskeletal components and a scavenger receptor inhibitor completely blocked the uptake of Baa-Lys(FITC)-(Lys)(8)-OH, suggesting a specific endocytics pathway was strongly involved in Baa(F ITC)- (Lys)8-OH cellular uptake. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Expression of Proinflammatory Cytokines by Human Mesenchymal Stem Cells in Response to Cyclic Tensile Strain

JOURNAL OF CELLULAR PHYSIOLOGY, 219(1), 77–83.

By: R. Sumanasinghe n, T. Pfeiler n, N. Monteiro-Riviere n & E. Loboa n

Contributors: R. Sumanasinghe n, T. Pfeiler n, N. Monteiro-Riviere n & E. Loboa n

MeSH headings : Animals; Bone Marrow Cells / cytology; Bone Marrow Cells / physiology; Cells, Cultured; Cytokines / metabolism; Humans; Interleukin-1beta / metabolism; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Stress, Mechanical; Stress, Physiological; Tensile Strength; Tumor Necrosis Factor-alpha / metabolism; Young Adult
TL;DR: IL‐6 and IL‐8 expressions by hMSCs were induced by cyclic tensile strain and osteogenic differentiating media, indicating that IL‐ 6 andIL‐8 may be functioning as autocrine signals during osteogenic differentiation of h MSCs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Fabrication of Polymer Microneedles Using a Two-Photon Polymerization and Micromolding Process

Journal of Diabetes Science and Technology, 3(2), 304–311.

By: S. Gittard n, A. Ovsianikov*, N. Monteiro-Riviere n, J. Lusk*, P. Morel*, P. Minghetti*, C. Lenardi*, B. Chichkov*, R. Narayan n

Contributors: S. Gittard n, A. Ovsianikov*, N. Monteiro-Riviere n, J. Lusk*, P. Morel*, P. Minghetti*, C. Lenardi*, B. Chichkov*, R. Narayan n

MeSH headings : Administration, Cutaneous; Biocompatible Materials; Diabetes Mellitus / drug therapy; Dimethylpolysiloxanes / chemistry; Drug Delivery Systems / instrumentation; Humans; Insulin / administration & dosage; Microtechnology / methods; Needles; Polymethacrylic Acids / chemical synthesis
TL;DR: The results suggest that a 2PP microfabrication and subsequent PDMS micromolding process may be used to create microneedle structures with appropriate structural, mechanical, and biological properties for transdermal drug delivery of insulin and other protein-based pharmacologic agents for treatment of diabetes mellitus. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 30, 2021

2009 chapter book

Human Health Risks of Engineered Nanomaterials

By: A. Elder*, I. Lynch*, K. Grieger*, S. Chan-Remillard*, A. Gatti*, H. Gnewuch*, E. Kenawy*, R. Korenstein* ...

Contributors: A. Elder*, I. Lynch*, K. Grieger*, S. Chan-Remillard*, A. Gatti*, H. Gnewuch*, E. Kenawy*, R. Korenstein* ...

TL;DR: This Working Group report summarizes the discussions of an expert scientific panel regarding the gaps in knowledge that impede effective human health risk assessment for nanomaterials, particularly those that are suspended in a gas or liquid and, thus, deposit on skin or in the respiratory tract. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: June 27, 2019

2009 chapter

Human health risks of engineered nanomaterials

In Nanomaterials: Risks and benefits (pp. 1–28). Dordrecht, Holland: Springer.

Nancy Monteiro-Riviere

Ed(s): I. Linkov & J. Steevens

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Interaction of nanomaterials with skin: Aspects of absorption and biodistribution

Nanotoxicology, 3(3), 188–193.

By: N. Monteiro-Riviere n & J. Riviere n

Contributors: N. Monteiro-Riviere n & J. Riviere n

author keywords: Absorption; biodistribution; nanomaterials; penetration; skin; drug delivery; cosmetics; exposure; nanomedicine
TL;DR: Research is beginning to be conducted to define the mechanistic framework describing nanomaterials biodistribution using pharmacokinetic models, suggesting that absorption is minimal, yet particle characteristics and species differences exist. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2009 journal article

Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line

TOXICOLOGY AND APPLIED PHARMACOLOGY, 234(2), 222–235.

By: N. Monteiro-Riviere n, A. Inman n & L. Zhang n

Contributors: N. Monteiro-Riviere n, A. Inman n & L. Zhang n

author keywords: Carbon; Nanomaterials; Carbon black; Single-walled carbon nanotubes; C-60; nC(60); Quantum dots; Calcein AM; Live/Dead; NR; MTT; Celltiter 96 (R) AQueous One; Alamar Blue; Celltiter-Blue (R); CytoTox One (TM); Flow cytometry; Human epidermal keratinocytes; Toxicity; Viability assays
MeSH headings : Cell Line; Cell Survival / drug effects; Drug Evaluation, Preclinical; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Humans; Keratinocytes / drug effects; Light; Microscopy, Electron, Transmission; Nanoparticles / toxicity; Oxazines; Quantum Dots; Scattering, Radiation; Spectrophotometry, Ultraviolet; Tetrazolium Salts; Thiazoles; Trypan Blue; Xanthenes
TL;DR: This study shows that, unlike small molecules, CNM interact with assay markers to cause variable results with classical toxicology assays and may not be suitable for assessing nanoparticle cytotoxicity, therefore, more than one assay may be required when determining nanoparticle toxicity for risk assessment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 article

Mechanisms of Quantum Dot Nanoparticle Cellular Uptake

Zhang, L. W., & Monteiro-Riviere, N. A. (2009, July). TOXICOLOGICAL SCIENCES, Vol. 110, pp. 138–155.

By: L. Zhang n & N. Monteiro-Riviere n

Contributors: L. Zhang n & N. Monteiro-Riviere n

author keywords: quantum dot nanoparticles; endocytosis; lipid rafts; G-protein-coupled receptor; scavenger receptor; cytotoxicity
MeSH headings : Actins / metabolism; Cell Membrane / metabolism; Cell Membrane / ultrastructure; Cells / drug effects; Cells / metabolism; Cytoplasm / metabolism; Cytoplasm / ultrastructure; Cytoskeleton / drug effects; Endosomes / drug effects; Flow Cytometry; Free Radical Scavengers / pharmacology; Humans; Immunohistochemistry; Indicators and Reagents; Keratinocytes / drug effects; Lysosomes / metabolism; Lysosomes / ultrastructure; Membrane Microdomains / drug effects; Membrane Potentials / drug effects; Microscopy, Confocal; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Pinocytosis / drug effects; Quantum Dots; Spectrometry, Fluorescence; Transport Vesicles / drug effects; Transport Vesicles / metabolism
TL;DR: It is shown that QD with a carboxylic acid surface coating were recognized by lipid rafts but not by clathrin or caveolae in human epidermal keratinocytes (HEKs) and endocytic pathways are primarily regulated by the G-protein-coupled receptor associated pathway and low density lipoprotein receptor/scavenger receptor. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Microfabricated curtains for controlled cell seeding in high throughput microfluidic systems

LAB ON A CHIP, 9(12), 1756–1762.

By: . Adrian T. O'Neill n, N. Monteiro-Riviere n & G. Walker n

Contributors: . Adrian T. O'Neill n, N. Monteiro-Riviere n & G. Walker n

MeSH headings : Cell Culture Techniques / instrumentation; Cell Movement; Cell Proliferation; Cell Survival / drug effects; Collagen / metabolism; Cytotoxins / toxicity; Dimethylpolysiloxanes; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Microfluidic Analytical Techniques / instrumentation; Nylons; Skin / cytology; Time Factors
TL;DR: Curtain use permitted high initial cell seeding densities and increased the amount of time cells can be cultured compared to multi-well plates and showed that cells exposed to 6% ethanol or less grew in population size, 8% ethanol exposure stunted growth, and higher concentrations led to population loss. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Nanoporous membranes for medical and biological applications

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 1(5), 568–581.

By: S. Adiga*, C. Jin*, L. Curtiss*, N. Monteiro-Riviere n & R. Narayan*

Contributors: S. Adiga*, C. Jin*, L. Curtiss*, N. Monteiro-Riviere n & R. Narayan*

MeSH headings : Biomedical Technology / methods; Drug Delivery Systems / methods; Humans; Membranes, Artificial; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Nanotechnology / methods; Permeability; Porosity
TL;DR: An overview of nanoporous membranes for biomedical applications, including biosensing, biosorting, immunoisolation, and drug delivery, are presented and desirable properties of membranes used in implantable devices, including biocompatibility and antibiofouling behavior are discussed. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2009 journal article

Pulsed laser deposition of antimicrobial silver coating on Ormocer (R) microneedles

BIOFABRICATION, 1(4).

By: S. Gittard n, R. Narayan n, C. Jin n, A. Ovsianikov*, B. Chichkov*, N. Monteiro-Riviere n, S. Stafslien*, B. Chisholm*

Contributors: S. Gittard n, R. Narayan n, C. Jin n, A. Ovsianikov*, B. Chichkov*, N. Monteiro-Riviere n, S. Stafslien*, B. Chisholm*

MeSH headings : Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Biotechnology; Cell Survival / drug effects; Ceramics / chemistry; Diffusion; Drug Delivery Systems / instrumentation; Humans; Keratinocytes; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Microtechnology / methods; Needles; Organically Modified Ceramics; Silanes / administration & dosage; Silanes / chemistry; Silver / administration & dosage; Silver / chemistry; Staphylococcus aureus / drug effects
TL;DR: It is indicated that coating microneedles with silver thin films using pulsed laser deposition is a useful and novel approach for creating microneEDles with antimicrobial functionality. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Pulsed laser deposition of antimicrobial silver coating on Ormocer microneedles.

Biofabrication, 1(4), 041001. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:20661316&KeyUID=MEDLINE:20661316

By: S. Gittard, R. Narayan, C. Jin, A. Ovsianikov, B. Chichkov, N. Monteiro-Riviere, S. Stafslien, B. Chisholm

Contributors: S. Gittard, R. Narayan, C. Jin, A. Ovsianikov, B. Chichkov, N. Monteiro-Riviere, S. Stafslien, B. Chisholm

Source: ORCID
Added: April 30, 2021

2009 journal article

Rapid prototyping of scaphoid and lunate bones

Biotechnology Journal, 4(1), 129–134.

By: S. Gittard n, R. Narayan n, J. Lusk*, P. Morel*, F. Stockmans*, M. Ramsey*, C. Laverde*, J. Phillips* ...

Contributors: S. Gittard n, R. Narayan n, J. Lusk*, P. Morel*, F. Stockmans*, M. Ramsey*, C. Laverde*, J. Phillips* ...

MeSH headings : Analysis of Variance; Cell Survival; Compressive Strength; Computer-Aided Design; Elastic Modulus; Humans; Keratinocytes / metabolism; Lunate Bone / anatomy & histology; Materials Testing; Polymers / chemistry; Prostheses and Implants; Prosthesis Design / methods; Resins, Synthetic / chemistry; Scaphoid Bone / anatomy & histology; Tomography, X-Ray Computed
TL;DR: The results of this study indicate that small bone prostheses fabricated by stereolithography using eShell 200 polymer may have suitable geometry, mechanical properties, and cytocompatibility properties for in vivo use. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 30, 2021

2009 book

Review of Federal Strategy for Nanotechnology-Related Environmental, Health, and Safety Research

By: D. Eaton, M. Philbert, G. Akexeeff, T. Bahadori, J. Balbus, M. Bawendi, P. Biswas, V. Colvin ...

Sources: Crossref, NC State University Libraries
Added: June 12, 2021

2009 journal article

Stretchable diamond-like carbon microstructures for biomedical applications

JOM, 61(9), 53–58.

By: R. Boehm*, R. Narayan*, R. Aggarwal n, N. Monteiro-Riviere* & S. Lacour*

Contributors: R. Boehm*, R. Narayan*, R. Aggarwal n, N. Monteiro-Riviere* & S. Lacour*

TL;DR: The use of pulsed laser deposition is described to create diamond-like carbon microstructures on polydimethylsiloxane to demonstrate the viability of human epidermal keratinocyte cells onpolydimethyl Siloxane surfaces coated with arrays of diamond- like carbon islands. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 chapter

Anatomical factors that affect barrier function

In K. P. W. H. Zhai & H. I. Maibach (Eds.), Dematotoxicology (7th ed.) (pp. 39–50). Boca Raton: Wiley & Sons.

By: N. Monteiro-Riviere

Ed(s): K. H. Zhai & H. Maibach

Source: NC State University Libraries
Added: August 6, 2018

2008 chapter

Animal skin morphology and dermal absorption

In M. S. Roberts & K. A. Walters (Eds.), Dermal absorption and toxicity assessment (2nd ed., pp. 17–35). New York: Informa Healthcare.

By: N. Monteiro-Riviere, R. Baynes & J. Riviere

Ed(s): M. Roberts & K. Walters

Source: NC State University Libraries
Added: August 6, 2018

2008 article

Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin

SKIN PHARMACOLOGY AND PHYSIOLOGY, Vol. 21, pp. 166–180.

By: L. Zhang n & N. Monteiro-Riviere*

Contributors: L. Zhang n & N. Monteiro-Riviere*

author keywords: quantum dots; nanoparticles; skin penetration; skin flexion; skin abrasion; tape-stripped skin
MeSH headings : Adhesives; Administration, Cutaneous; Animals; Dermabrasion; Microscopy, Confocal; Permeability; Quantum Dots; Rats; Rats, Wistar; Skin / metabolism; Skin Absorption; Spectrometry, Fluorescence
TL;DR: The results indicate that the rat skin penetration of QD655 and QD565 is primarily limited to the uppermost stratum corneum layers of intact skin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 journal article

Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes

TOXICOLOGY AND APPLIED PHARMACOLOGY, 228(2), 200–211.

By: L. Zhang n, W. Yu*, V. Colvin* & N. Monteiro-Riviere n

Contributors: L. Zhang n, W. Yu*, V. Colvin* & N. Monteiro-Riviere n

author keywords: quantum dot; nanoparticles; skin penetration; cytokines; keratinocytes; cellular uptake; inflammation; skin
MeSH headings : Animals; Cell Line; Cell Survival / drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Fluorescence; Fluorometry / methods; Humans; Hydrogen-Ion Concentration; Interleukins / metabolism; Keratinocytes / chemistry; Keratinocytes / drug effects; Keratinocytes / ultrastructure; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Particle Size; Polyethylene Glycols / chemistry; Quantum Dots; Receptor Protein-Tyrosine Kinases / metabolism; Receptor, EphA3; Spectrometry, Mass, Electrospray Ionization / methods; Swine; Tumor Necrosis Factor-alpha / metabolism
TL;DR: Results indicate that porcine skin penetration of QD621 is minimal and limited primarily to the outer SC layers, yet if the skin were damaged allowing direct QD exposure to skin or keratinocytes, an inflammatory response could be initiated. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 journal article

COLL 95-Assessment of quantum dot nanoparticle penetration in human skin

Abstracts of Papers of the American Chemical Society, 236. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000270256303852&KeyUID=WOS:000270256303852

By: N. Monteiro-Riviere & A. Inman

Contributors: N. Monteiro-Riviere & A. Inman

Source: ORCID
Added: June 27, 2019

2008 journal article

Characterization of microfluidic human epidermal keratinocyte culture

CYTOTECHNOLOGY, 56(3), 197–207.

By: . Adrian T. O'Neill*, N. Monteiro-Riviere* & G. Walker*

Contributors: . Adrian T. O'Neill*, N. Monteiro-Riviere* & G. Walker*

author keywords: cytotoxicity; high-throughput; keratinocyte; microfluidic; PDMS; toxicology
TL;DR: Human epidermal keratinocytes were shown to maintain 93.0%–99.6% viability at 72 h under medium perfusion ranging from 0.025–0.4 μl min−1, a level not possible in 96 well plates. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 journal article

Cyclic tensile strain increases interactions between human epidermal keratinocytes and quantum dot nanoparticles

TOXICOLOGY IN VITRO, 22(2), 491–497.

By: J. Rouse n, C. Haslauer n, E. Loboa n & N. Monteiro-Riviere n

Contributors: J. Rouse n, C. Haslauer n, E. Loboa n & N. Monteiro-Riviere n

author keywords: quantum dot nanoparticles; keratinocytes; skin; tensile strain; cellular uptake
MeSH headings : Borates / toxicity; Cell Membrane Permeability / drug effects; Cell Survival / drug effects; Cells, Cultured; Cytokines / analysis; Cytokines / biosynthesis; Epidermal Cells; Epidermis / drug effects; Ethidium; Fluoresceins; Fluorescent Dyes; Humans; Keratinocytes / drug effects; Keratinocytes / physiology; Microscopy, Fluorescence; Pharmaceutical Vehicles / chemistry; Polyethylene Glycols / chemistry; Quantum Dots; Tensile Strength
TL;DR: Application of physiological load conditions can increase cell membrane permeability, thereby increasing the concentration of QD nanoparticles in cells, and addition of strain results in an increase in cytokine production and QD uptake, resulting in irritation and a negative impact on cell viability. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 chapter

Dermatotoxicology

In R. C. Smart & E. Hodgson (Eds.), Molecular and biochemical toxicology (4th ed.) (pp. 851–880).

By: N. Monteiro-Riviere n

Contributors: N. Monteiro-Riviere n

Ed(s): R. Smart & E. Hodgson

Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018

2008 journal article

Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes

JOURNAL OF APPLIED TOXICOLOGY, 28(4), 543–553.

By: A. Inman n, N. Monteiro-Riviere n & J. Riviere n

Contributors: A. Inman n, N. Monteiro-Riviere n & J. Riviere n

author keywords: jet fuel; JP-8; skin toxicity; S-8; NF-kappa B; parthenolide; isohelenin; substance P; SB 203580; recombinant human IL-10
MeSH headings : Alkanes / toxicity; Anti-Inflammatory Agents / metabolism; Anti-Inflammatory Agents / pharmacology; Cell Survival / drug effects; Cells, Cultured; Cytokines / metabolism; Humans; Hydrocarbons / toxicity; Imidazoles / pharmacology; Interleukin-10 / metabolism; Irritants / toxicity; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; NF-kappa B / antagonists & inhibitors; NF-kappa B / metabolism; Protein Kinase Inhibitors / pharmacology; Pyridines / pharmacology; Recombinant Proteins / metabolism; Sesquiterpenes / pharmacology; Substance P / metabolism; Time Factors
TL;DR: This study shows that inhibiting NF‐κB, which appears to play a role in cytokine production in HC‐exposed HEK in vitro, may reduce the inflammatory effect of HC in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 journal article

Mechanical and biological properties of nanoporous carbon membranes

BIOMEDICAL MATERIALS, 3(3).

By: R. Narayan*, R. Aggarwal*, W. Wei*, C. Jin*, N. Monteiro-Riviere n, R. Crombez*, W. Shen*

Contributors: R. Narayan*, R. Aggarwal*, W. Wei*, C. Jin*, N. Monteiro-Riviere n, R. Crombez*, W. Shen*

MeSH headings : Carbon / administration & dosage; Carbon / chemistry; Cell Survival / drug effects; Cells, Cultured; Elasticity; Hardness; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Materials Testing; Membranes, Artificial; Nanostructures / administration & dosage; Nanostructures / chemistry; Nanostructures / ultrastructure; Particle Size; Porosity; Stress, Mechanical; Tensile Strength
TL;DR: The structural, mechanical and biological properties of nanoporous alumina membranes coated with diamond-like carbon thin films were examined and it is anticipated that this novel membrane material could find use in immunoisolation devices, kidney dialysis membranes and other medical devices encountering biocompatibility issues that limit in vivo function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 journal article

Nanoceria as antioxidant: Synthesis and biomedical applications

JOM, 60(3), 33–37.

By: A. Karakoti*, N. Monteiro-Riviere n, R. Aggarwal n, J. Davis n, R. Narayan n, W. Self*, J. McGinnis*, S. Seal*

Contributors: A. Karakoti*, N. Monteiro-Riviere n, R. Aggarwal n, J. Davis n, R. Narayan n, W. Self*, J. McGinnis*, S. Seal*

TL;DR: The therapeutic application of nanomaterials has been a focus of numerous studies in the past decade, and the radical-scavenging role of ceria nanoparticles (nanoceria) have been established, as well as the autocatalytic ability of nanoceria to regenerate under various environmental conditions. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 chapter

Solvents and vehicle effects on the skin

In M. S. Roberts & K. A. Walters (Eds.), Dermal absorption and toxicity assessment. (2nd ed.) (pp. 433–447). New York: Informa Healthcare.

By: M. Roberts, A. Gierden, J. Riviere & N. Monteiro-Riviere

Ed(s): M. Roberts & K. Walters

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Topical isoflavones provide effective photoprotection to skin

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, 24(2), 61–66.

By: J. Lin*, J. Tournas, J. Burch, N. Monteiro-Riviere* & J. Zielinski

Contributors: J. Lin*, J. Tournas, J. Burch, N. Monteiro-Riviere* & J. Zielinski

author keywords: antioxidants; isoflavones; photoprotection
MeSH headings : Administration, Cutaneous; Animals; Ascorbic Acid / administration & dosage; Ascorbic Acid / pharmacology; Ascorbic Acid / therapeutic use; Coumaric Acids / administration & dosage; Coumaric Acids / pharmacology; Coumaric Acids / therapeutic use; Dose-Response Relationship, Drug; Drug Combinations; Equol; Genistein / administration & dosage; Genistein / pharmacology; Genistein / therapeutic use; Isoflavones / administration & dosage; Isoflavones / pharmacology; Isoflavones / therapeutic use; Phytotherapy; Plants, Medicinal; Skin / drug effects; Skin / radiation effects; Sunburn / pathology; Sunburn / prevention & control; Sunlight / adverse effects; Sunscreening Agents / administration & dosage; Sunscreening Agents / pharmacology; Sunscreening Agents / therapeutic use; Swine; Vitamin E / administration & dosage; Vitamin E / pharmacology; Vitamin E / therapeutic use
TL;DR: The aim of this study is to obtain a more comprehensive understanding of the isoflavone‐mediated photoprotection with the pig skin model, a more human‐resembling model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 chapter

Toxicological impacts of nanomaterials

In M. R. Wiesner & J. Y. Bottero (Eds.), Environmental nanotechnology: Applications and impacts of nanomaterials (pp. 395–444). New York: McGraw-Hill.

By: N. Monteiro-Riviere & T. Orsiere

Ed(s): M. Wiesner & J. Bottero

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

A linear dilution microfluidic device for cytotoxicity assays

LAB ON A CHIP, 7(2), 226–232.

By: G. Walker n, N. Monteiro-Riviere n, J. Rouse n & . Adrian T. O'Neill n

Contributors: G. Walker n, N. Monteiro-Riviere n, J. Rouse n & . Adrian T. O'Neill n

MeSH headings : Cells, Cultured; Combinatorial Chemistry Techniques; Diffusion; Drug Evaluation, Preclinical / instrumentation; Drug Evaluation, Preclinical / methods; Electrochemistry / methods; Equipment Design; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Microchemistry; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods; Microfluidics; Models, Statistical; Models, Theoretical
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

A system coefficient approach for quantitative assessment of the solvent effects on membrane absorption from chemical mixtures

SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 18(5-6), 579–593.

By: X. Xia n, R. Baynes n, N. Monteiro-Riviere n & J. Riviere n

Contributors: X. Xia n, R. Baynes n, N. Monteiro-Riviere n & J. Riviere n

author keywords: membrane absorption; chemical mixtures; solvent effects; system coefficient approach; solute descriptors
MeSH headings : Absorption; Dimethylpolysiloxanes / chemistry; Dimethylpolysiloxanes / metabolism; Kinetics; Membranes, Artificial; Models, Biological; Models, Chemical; Quantitative Structure-Activity Relationship; Regression Analysis; Silicones / chemistry; Silicones / metabolism; Solvents / chemistry
TL;DR: A system coefficient approach is proposed for quantitative assessment of the solvent effects on membrane absorption from chemical mixtures using Polydimethylsiloxane membrane-coated fibres and 32 probe compounds to demonstrate the proposed approach. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber array

TOXICOLOGY AND APPLIED PHARMACOLOGY, 221(3), 320–328.

By: X. Xia n, R. Baynes n, N. Monteiro-Riviere n & J. Riviere n

Contributors: X. Xia n, R. Baynes n, N. Monteiro-Riviere n & J. Riviere n

author keywords: skin permeability; predictive model; membrane-coated fiber; distribution coefficients; percutaneous absorption
MeSH headings : Algorithms; Complex Mixtures / chemistry; Complex Mixtures / pharmacokinetics; Forecasting; Humans; Membranes, Artificial; Models, Biological; Organic Chemicals / chemistry; Organic Chemicals / pharmacokinetics; Permeability; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / metabolism; Reproducibility of Results; Skin / metabolism; Skin Absorption / drug effects; Structure-Activity Relationship
TL;DR: The MCF array approach is an experimentally based, high throughput approach that provides high prediction confidence and does not require literature data nor molecular structure information in contrast to the existing predictive models. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 chapter

Animal skin morphology and dermal absorption

In Dermal Absorption and Toxicity Assessment, Second Edition (pp. 17–36). http://www.scopus.com/inward/record.url?eid=2-s2.0-77952889776&partnerID=MN8TOARS

By: N. Monteiro-Riviere, R. Baynes & J. Riviere

Contributors: N. Monteiro-Riviere, R. Baynes & J. Riviere

Source: ORCID
Added: September 25, 2022

2007 journal article

Biodistribution of quantum dot nanoparticles in perfused skin: Evidence of coating dependency and periodicity in arterial extraction

NANO LETTERS, 7(9), 2865–2870.

By: H. Lee n, M. Imran n, N. Monteiro-Riviere n, V. Colvin n, W. Yu n & J. Rivlere

Contributors: H. Lee n, M. Imran n, N. Monteiro-Riviere n, V. Colvin n, W. Yu n & J. Rivlere

MeSH headings : Animals; Arteries / chemistry; Coated Materials, Biocompatible / chemistry; Diffusion; Perfusion; Quantum Dots; Skin / blood supply; Skin / chemistry; Skin Absorption / physiology; Swine; Tissue Distribution
TL;DR: Both QD had a unique periodicity in arterial extraction never observed with drug infusions, suggesting a potentially important nanomaterial behavior that could affect systemic disposition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Biological interactions of functionalized single-wall carbon nanotubes in human epidermal keratinocytes

INTERNATIONAL JOURNAL OF TOXICOLOGY, 26(2), 103–113.

By: L. Zhang n, L. Zeng*, A. Barron* & N. Monteiro-Riviere n

Contributors: L. Zhang n, L. Zeng*, A. Barron* & N. Monteiro-Riviere n

author keywords: cytokines; keratmocytes; nanomaterials; nanotoxicology; single-wall carbon nanotubes; skin
MeSH headings : Aminocaproic Acid / chemistry; Cell Line; Cell Survival / drug effects; Cytokines / metabolism; Cytoplasmic Vesicles / drug effects; Cytoplasmic Vesicles / metabolism; Cytoplasmic Vesicles / ultrastructure; Dose-Response Relationship, Drug; Drug Antagonism; Drug Carriers / chemistry; Drug Carriers / toxicity; Drug Combinations; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Humans; Microscopy, Electron, Transmission; Nanotechnology; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Poloxamer / pharmacology; Surface-Active Agents / pharmacology
TL;DR: Human epidermal keratinocytes (HEKs) were dosed with 6-Aminohexanoic acid–derivatized single-wall carbon nanotubes and data showed that the lower concentration of 0.000005 mg/ml of AHA-SWNTs maintains cell viability and induces a mild cytotoxicity, but the higher concentration demonstrated an irritation response by the increase in IL-8. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Biological properties of carbon nanotubes

Journal of Nanoscience and Nanotechnology, 7(4-5), 1284–1297.

By: