Nancy A Monteiro-Riviere
Also known as: N.A. Monteiro-Riviere; Nancy A Monteiro-Riviere; Monteiro-Riviere NA
nanoparticle toxicity, protein corona, nanotoxicology, skin absorption, toxicity, skin penetration
Nancy A. Monteiro-Riviere PhD, ATS, was the Regents Distinguished Research Scholar and University Distinguished Professor and Founding Director of the Nanotechnology Innovation Center of Kansas State. She did a postdoctoral fellowship in toxicology at Chemical Industry Institute of Toxicology in RTP, NC. She was Professor of Investigative Dermatology and Toxicology at North Carolina State University (NCSU) for 28 years and Professor in the Joint Department of Biomedical Engineering at UNC-Chapel Hill/NCSU and Research Adjunct Professor of Dermatology, at UNC-Chapel Hill School of Medicine. She was past-President of both the Dermal and In Vitro Specialty sections of the Society of Toxicology and selected as an Eminent Toxicologist in March 2016 by the National Society of Toxicology. Dr. Monteiro-Riviere is a Fellow in The Academy of Toxicological Sciences and was elected to its Board of Directors. She was the recipient of the Purdue University Inaugural Distinguished Women Scholars Award, KSU Woman of Distinction, and elected to attend the National Academy of Sciences Keck Futures Initiative. She is Associate Editor for two and serves on the editorial board of six other toxicology journals; as well as on several national (NRC) and international (EU) expert review panels. She was on Thomson Reuters’s 2014 list of the top 1% most highly cited researchers in pharmacology and toxicology. She published over 330 manuscripts in skin toxicology and nanotoxicology and is Editor of three books in toxicology: “Nanotoxicology Characterization and Dosing and Health Effects”, “Toxicology of the Skin -Target Organ Series” and the latest in CRC Press “Nanotoxicology: Progress toward Nanomedicine”. Her research interests involve in vivo and in vitro studies of skin absorption, penetration and toxicity of chemicals, nanoparticles, and the effect of the biocorona on uptake and cellular responses to nanomaterials.
Works (387)
Updated: April 4th, 2024 04:46
2023 journal article
An artificial intelligence-assisted physiologically-based pharmacokinetic model to predict nanoparticle delivery to tumors in mice
JOURNAL OF CONTROLLED RELEASE, 361, 53–63.
author keywords: Artificial intelligence; Machine learning; Physiologically based pharmacokinetic; modeling; Nanomedicine; Drug delivery; Nanotechnology
TL;DR:
An AI-assisted physiologically based pharmacokinetic (PBPK) model is established by integrating an AI-based quantitative structure-activity relationship (QSAR) model with a PBPK model to simulate tumor-targeted delivery efficiency (DE) and biodistribution of various NPs.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 7, 2023
2023 journal article
Meta-Analysis of Nanoparticle Distribution in Tumors and Major Organs in Tumor-Bearing Mice
ACS NANO, 17(20), 19810–19831.
author keywords: Nanoparticle; Tumor delivery; Tissue distribution; Cancer; Nanomedicine
TL;DR:
An updated version of “Nano-Tumor Database” is reported, which increases the number of time-dependent concentration data sets for different nanoparticles (NPs) in tumors from the previous version of 376 data sets to 534 data sets with 2345 data points from 297 studies published from 2005 to 2021.
(via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 10, 2023
2022 journal article
Biocorona modulates the inflammatory response induced by gold nanoparticles in human epidermal keratinocytes
Toxicology Letters, 369, 34–42.
MeSH headings : Antioxidants; Gold / chemistry; Gold / toxicity; Humans; Keratinocytes / metabolism; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; NF-E2-Related Factor 2 / genetics; Polyethyleneimine / chemistry; Protein Corona / chemistry; Protein Corona / metabolism; Thioctic Acid / pharmacology
TL;DR:
It is discovered that nuclear factor erythroid-2 related factor (Nrf2), a major regulator of anti-oxidant and anti-inflammatory gene, is the key factor related to the AuNPs induced oxidative stress and inflammation.
(via Semantic Scholar)
Source: ORCID
Added: August 7, 2023
2022 journal article
Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in rats
Particle and Fibre Toxicology, 19(1).
Contributors: W. Chou*, Y. Cheng *, J. Riviere *, * , W. Kreyling* & Z. Lin *
author keywords: Biodistribution; Endocytosis; Gold nanoparticles; Nanomedicine; Nanotoxicology; Physiologically based pharmacokinetic (PBPK) modeling
MeSH headings : Animals; Bayes Theorem; Gold; Metal Nanoparticles; Models, Biological; Rats; Tissue Distribution
TL;DR:
The size and surface area of AuNPs were the main determinants for endocytic/phagocytic uptake rates regardless of the route of administration, while Zeta potential was an important parameter for the estimation of the exocytic release rates following IV administration.
(via Semantic Scholar)
Source: ORCID
Added: September 25, 2022
2022 review
Perspectives of nanotoxicology: Introduction
[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 14(6).
MeSH headings : Nanostructures / toxicity; Nanotechnology
TL;DR:
This Nanotoxicology specialty issue begins with an overview of the methods used to conduct toxicokinetics, dose-response and risk assessment of nanomaterials: methodology, challenges, and future perspectives and specifically focuses on the experimen-tal design of plasma and tissue toxicokinetic.
(via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 23, 2022
2022 journal article
Predicting Nanoparticle Delivery to Tumors Using Machine Learning and Artificial Intelligence Approaches
INTERNATIONAL JOURNAL OF NANOMEDICINE, 17, 1365–1379.
Contributors: Z. Lin, W. Chou, Y. Cheng *, C. He *, n & J. Riviere n
author keywords: artificial intelligence; machine learning; physiologically based pharmacokinetic modeling; nanomedicine; drug delivery; nanotechnology
MeSH headings : Artificial Intelligence; Humans; Machine Learning; Nanoparticles; Neoplasms / drug therapy; Neural Networks, Computer
TL;DR:
The deep neural network model adequately predicted the delivery efficiency of different NPs to different tumors and it outperformed all other machine learning methods; including random forest, support vector machine, linear regression, and bagged model methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 30, 2022
2021 journal article
The synergistic strategies for the immuno‐oncotherapy with photothermal nanoagents
WIREs Nanomedicine and Nanobiotechnology, 13(5).
Contributors: Y. Zhang *, G. Zhang *, G. Wang *, L. Wu *, * & Y. Li *
author keywords: immune checkpoints; immuno‐ oncotherapy; nanomaterials; nanoagents; photothermal therapy; synergistic oncotherapy
MeSH headings : Adjuvants, Immunologic; Humans; Immunotherapy; Nanomedicine; Nanostructures; Neoplasms / therapy; Photothermal Therapy
TL;DR:
This review summarizes the recent studies on the synergistic strategies for the immuno-oncotherapy based on photothermal nanoagents and the mechanisms that trigger the systemic anti-tumor immune responses and PTT-synergized immunosuppressive conditions simultaneously.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 26, 2021
2020 journal article
Amino/Amido Conjugates Form to Nanoscale Cobalt Physiometacomposite (PMC) Materials Functionally Delivering Nucleic Acid Therapeutic to Nucleus Enhancing Anticancer Activity via Ras-Targeted Protein Interference
ACS Applied Bio Materials, 3(1), 175–179.
Contributors: R. Delong *, J. Dean*, G. Glaspell*, M. Jaberi-Douraki *, K. Ghosh*, D. Davis*, * , P. Chandran *
author keywords: PMC; ZnO; cobalt; nickel; B16F10; HEK; A375
TL;DR:
Preclinical potential of PMC for delivery of SSO, RBD, or other nucleic acid therapeutic and anticancer peptides is suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 8, 2020
2020 content posted
Gold Nanoparticles Induce Cell Stress by Interfering with the Cellular Protein Quality Control System
TL;DR:
This study for the first time shows that NPs can interfere with the cellular PQC system by impairing ERAD activity, which in turn initiates a cascade of events leading to cell death and inflammation.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: October 16, 2020
2020 article
Gold Nanoparticles Induce Cell Stress by Interfering with the Cellular Protein Quality Control System
ResearchSquare.
Source: ORCID
Added: September 25, 2022
2020 journal article
Meta-Analysis of Nanoparticle Delivery to Tumors Using a Physiologically Based Pharmacokinetic Modeling and Simulation Approach
ACS Nano, 14(3), 3075–3095.
Contributors: Y. Cheng *, C. He *, J. Riviere*, * & Z. Lin *
author keywords: advanced material; drug delivery; nanomedicine; nanoparticle; physiologically based pharmacokinetic modeling; tissue biothstribution; tumor delivery
MeSH headings : Animals; Disease Models, Animal; Drug Carriers / chemistry; Drug Delivery Systems; Gold / administration & dosage; Gold / chemistry; Gold / pharmacokinetics; Injections, Intravenous; Male; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Neoplasms / chemistry; Neoplasms / metabolism; Tissue Distribution
TL;DR:
The potential causes of this poor delivery efficiency were explored using the more mechanistic PBPK perspective applied to a subset of gold nanoparticles and it was found that low delivery efficiency was associated with low distribution and permeability coefficients at the tumor site.
(via Semantic Scholar)
Sources: ORCID, Crossref
Added: March 5, 2020
2019 journal article
Toxicity assessment of six titanium dioxide nanoparticles in human epidermal keratinocytes
Cutaneous and Ocular Toxicology, 38(1), 66–80.
Contributors: L. Zhang * & *
author keywords: Titanium dioxide nanoparticles; human epidermal keratinocytes; cell viability; cytokine release; cellular uptake
MeSH headings : Cells, Cultured; Cytokines / metabolism; Humans; Keratinocytes / drug effects; Keratinocytes / metabolism; Metal Nanoparticles / toxicity; Titanium / toxicity
TL;DR:
Based on cell viability, only sample B was slightly cytotoxic to HEK and samples B and A* have the potential to cause inflammation indicated by an increase in IL-6.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: June 27, 2019
2018 journal article
Modeling gold nanoparticle biodistribution after arterial infusion into perfused tissue: effects of surface coating, size and protein corona
Nanotoxicology, 12(10), 1093–1112.
Contributors: J. Riviere*, M. Jaberi-Douraki *, J. Lillich*, T. Azizi *, H. Joo*, K. Choi*, R. Thakkar*, *
author keywords: Biodistribution; gold nanoparticles; cell uptake; skin; pharmacokinetics; nanoparticle vascular distribution
MeSH headings : Animals; Epigastric Arteries; Female; Free Tissue Flaps; Gold / administration & dosage; Gold / chemistry; Gold / pharmacokinetics; Humans; Infusions, Intra-Arterial; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Models, Biological; Nanomedicine; Particle Size; Perfusion; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / chemistry; Skin / blood supply; Skin / metabolism; Surface Properties; Swine; Thioctic Acid / chemistry; Tissue Distribution
TL;DR:
These studies paralleled previous in vitro cell culture studies using the same AuNP in human endothelial and renal proximal tubule cells, hepatocytes, keratinocytes, showing BPEI-AuNP having the greatest uptake, although the presence of a PPC did not reduce IPPSF biodistribution as in the cellculture studies.
(via Semantic Scholar)
Sources: ORCID, Crossref
Added: June 27, 2019
2018 journal article
Probabilistic risk assessment of gold nanoparticles after intravenous administration by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling
Nanotoxicology, 12(5), 453–469.
Contributors: Y. Cheng *, J. Riviere*, * & Z. Lin *
author keywords: Gold nanoparticle; computational nanotoxicology; physiologically based pharmacokinetic modeling; probabilistic risk assessment
MeSH headings : Administration, Intravenous; Animals; Bayes Theorem; Gold / administration & dosage; Gold / pharmacokinetics; Gold / toxicity; Humans; Metal Nanoparticles / toxicity; Models, Biological; Monte Carlo Method; Risk Assessment
TL;DR:
The results suggest that under the highest dosing level employed in existing animal studies (worst-case scenario), AuNPs coated with branched polyethylenimine (BPEI) would likely induce ∼90–100% cellular death, implying high cytotoxicity compared to <10% cell death induced by low-to-medium animal dosing levels, which are commonly used in animal studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref
Added: June 27, 2019
2017 journal article
Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation
Nanotoxicology, 11(9-10), 1157–1175.
Contributors: Y. Li *, Z. Shi *, I. Radauer-Preiml*, A. Andosch*, E. Casals *, U. Luetz-Meindl*, M. Cobaleda*, Z. Lin *
author keywords: Nano-immunosafety; endotoxin contamination; biocorona modulation; gold nanoparticles; inflammatory effects
MeSH headings : Adsorption; Blood Proteins / chemistry; Computational Biology; Gold / chemistry; Gold / toxicity; HEK293 Cells; Humans; Inflammation; Interleukin-1 / biosynthesis; Lipopolysaccharides / chemistry; Lipopolysaccharides / toxicity; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Models, Biological; Monocytes / drug effects; Monocytes / immunology; Particle Size; Protein Corona / analysis; Surface Properties
TL;DR:
The unintentional adsorption of LPS onto the NP surface can affect the biocorona formation and the inflammatory properties of NPs.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2017 journal article
Biocorona formation on gold nanoparticles modulates human proximal tubule kidney cell uptake, cytotoxicity and gene expression
Toxicology in Vitro, 42, 150–160.
author keywords: Gold nanoparticles; Human proximal tubule cells; Protein corona; Cellular uptake; Gene expression; Mechanisms of toxicity
MeSH headings : Cells, Cultured; Cytokines / metabolism; Gene Expression / drug effects; Gold / administration & dosage; Gold / chemistry; Gold / toxicity; Humans; Kidney Tubules, Proximal / cytology; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Plasma / chemistry; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / chemistry; Serum Albumin / chemistry; Thioctic Acid / chemistry
TL;DR:
These studies clearly showed reduced uptake and cytotoxicity, as well as differentiated gene expression of AuNP with PCs, questioning the utility of in vitro studies using bare NP to assess in vivo effects, suggesting the relative safety of PEG and LA-AuNP as nanomedicine constructs.
(via Semantic Scholar)
Sources: ORCID, Crossref
Added: June 27, 2019
2017 chapter
Multi-walled carbon nanotube exposure alters protein expression in human keratinocytes
In Nanomedicine in Cancer (pp. 461–485).
Source: ORCID
Added: September 25, 2022
2017 chapter
TL;DR:
The role of the skin as a potential route of exposure to nanomaterials is described in the present chapter and in vitro systems and differences in animal species provide limitations for a complete understanding of nanoparticle penetration through the skin.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 26, 2021
2017 journal article
Surface chemistry of gold nanoparticles determines the biocorona composition impacting cellular uptake, toxicity and gene expression profiles in human endothelial cells
Nanotoxicology, 11(4), 507–519.
Contributors: P. Chandran *, J. Riviere* & *
author keywords: Biocorona; gold nanoparticles; surface chemistry; endothelial cells; mechanistic toxicology
MeSH headings : Albumins / metabolism; Cell Survival / drug effects; Circular Dichroism; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Gold / chemistry; Gold / toxicity; Human Umbilical Vein Endothelial Cells; Humans; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Particle Size; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / metabolism; Proteomics; Surface Properties; Transcriptome / drug effects
TL;DR:
NP surface chemistry is shown to play the dominant role over size in determining the biocorona composition, which in turn modulates cell uptake, and biological responses, consequently defining the potential safety and efficacy of nanoformulations.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID, Web Of Science
Added: April 29, 2021
2016 journal article
A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles
Nanomedicine, 11(2), 107–119.
Contributors: Z. Lin *, * , R. Kannan* & J. Riviere*
author keywords: biodistribution; computational nanotoxicology; endocytosis; nanomaterials; PBPK modeling; physiologically based pharmacokinetic modeling; phagocytosis; toxicokinetics
MeSH headings : Animals; Cell Survival / drug effects; Computer Simulation; Dose-Response Relationship, Drug; Environmental Exposure / adverse effects; Gold / pharmacokinetics; Gold / toxicity; Humans; Metabolic Clearance Rate; Mice; Models, Biological; Nanoparticles / toxicity; Rats; Species Specificity; Swine; Tissue Distribution; Toxicity Tests / methods
TL;DR:
These results partially explain the current low translation rate of nanotechnology-based drug delivery systems from mice to humans and may be applied to other nanomaterials and provides guidance to design future translational studies.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2016 journal article
A physiologically based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice
Nanotoxicology, 10(2), 162–172.
Contributors: Z. Lin *, * & J. Riviere *
author keywords: Biodistribution; endocytosis; gold nanoparticles; pharmacokinetics; PBPK modeling
MeSH headings : Animals; Calibration; Computer Simulation; Endocytosis / physiology; Gold / pharmacokinetics; Humans; Metal Nanoparticles / chemistry; Mice; Models, Biological; Particle Size; Polyethylene Glycols / pharmacokinetics; Tissue Distribution
TL;DR:
A membrane-limited physiologically based pharmacokinetic (PBPK) model for polyethylene glycol-coated gold (Au) NPs (PEG- coated AuNPs) was developed in mice, providing useful insights into the size, time, and species dependence of NP pharmacokinetics.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2016 journal article
Assessing the safety of cosmetic chemicals: Consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)
Regulatory Toxicology and Pharmacology, 76, 174–186.
Contributors: F. Williams *, H. Rothe, G. Barrett*, A. Chiodini *, J. Whyte*, M. Cronin *, * , J. Plautz
author keywords: Threshold of Toxicological Concern (TTC); Dermal; Cosmetic chemical; Systemic bioavailability; Decision tree; Prediction; Flux
MeSH headings : Administration, Cutaneous; Administration, Oral; Algorithms; Animals; Biological Availability; Consumer Product Safety; Cosmetics / administration & dosage; Cosmetics / pharmacokinetics; Cosmetics / toxicity; Decision Trees; Dose-Response Relationship, Drug; Humans; Intestinal Absorption; Models, Biological; No-Observed-Adverse-Effect Level; Risk Assessment; Skin / metabolism; Skin Absorption; Toxicity Tests / methods
TL;DR:
The objective here was to explore the potential refinement of exposure for applying the oral TTC to chemicals found in cosmetic products, for which there are limited dermal absorption data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2016 journal article
Biocorona Bound Gold Nanoparticles Augment Their Hematocompatibility Irrespective of Size or Surface Charge
ACS Biomaterials Science & Engineering, 2(9), 1608–1618.
Contributors: A. Sasidharan *, P. Chandran * & *
author keywords: gold nanoparticles; nanoparticle surface chemistry; protein corona; hematotoxicity; blood components
TL;DR:
It is suggested that, irrespective of the physicochemical properties, the adsorption of the PC over AuNP significantly influences its biological impact by alleviating adverse hematotoxicity of bare NP.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2016 chapter
Cell and Protein Interactions with Diamond
In R. Bawa, G. F. Audette, & B. Reese (Eds.), Handbook of Clinical Nanomedicine: Law, Business, Regulation, Safety and Risk (pp. 809–822).
Ed(s): R. Bawa, G. Audette & B. Reese
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: December 6, 2018
2016 journal article
Intracellular imaging of quantum dots, gold, and iron oxide nanoparticles with associated endocytic pathways
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 9(2), e1419.
Contributors: D. Chen *, * & L. Zhang *
MeSH headings : Animals; Cell Line; Cell Membrane / chemistry; Cell Membrane / metabolism; Endocytosis / physiology; Gold; Humans; Intracellular Space / chemistry; Intracellular Space / diagnostic imaging; Intracellular Space / metabolism; Membrane Microdomains; Metal Nanoparticles; Mice; Molecular Imaging / methods; Nanomedicine; Quantum Dots
TL;DR:
Knowing the different methodologies used to determine the endocytic pathways will increase the understanding of NP toxicity, cancer cell targeting, and imaging, so that surface coatings can be created for efficient cell uptake of metallic NP with minimal cytotoxicity.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 26, 2021
2016 journal article
Mechanisms of cell uptake, inflammatory potential and protein corona effects with gold nanoparticles
Nanomedicine, 11(24), 3185–3203.
Contributors: Y. Li * & *
author keywords: endocytosis; gold nanoparticles; human epidermal keratinocytes; inflammation; mechanisms of cellular uptake; protein corona
MeSH headings : Blood Proteins / metabolism; Cells, Cultured; Endocytosis / drug effects; Gold / chemistry; Gold / pharmacology; Humans; Inflammation / chemically induced; Inflammation / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Metal Nanoparticles / chemistry; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / metabolism; Thioctic Acid / chemistry
TL;DR:
Results suggest protein coronas significantly affect cellular uptake and inflammatory responses of AuNP, and suggest BPEI-AuNP showed the greatest uptake, while PEG- auNP had the least.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2016 journal article
Mechanistic Toxicity Assessment of Hexahydroisohumulone in Canine Hepatocytes, Renal Proximal Tubules, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like Cells
International Journal of Veterinary Health Science & Research, 4(2), 88–103.
TL;DR:
Investigating organ-specific oxidative stress and the molecular mechanism of toxicity using the pathway-focused DNA array of the hop ingredient hexahydroisohumulone with canine hepatocytes, canine proximal tubule cells, bone marrow-derived mesenchymal stem cells and enterocyte-like cells provides insight into genes altered with HEX exposure and the cell-type specific responses in dogs.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 29, 2021
2016 journal article
Oxidative stress response in canine in vitro liver, kidney and intestinal models with seven potential dietary ingredients
Toxicology Letters, 241, 49–59.
Contributors: K. Choi*, M. Ortega*, B. Jeffery, J. Riviere* & *
author keywords: In vitro canine culture systems; Multiple organ-derived cells; Dietary ingredients; Organ-specific oxidative stress
MeSH headings : Animals; Antioxidants / chemistry; Antioxidants / pharmacology; Bone Marrow Cells / drug effects; Bone Marrow Cells / metabolism; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Food; Food Analysis; Hepatocytes / drug effects; Intestinal Mucosa / metabolism; Intestines / drug effects; Kidney / drug effects; Kidney / metabolism; Kidney Tubules, Proximal / cytology; Kidney Tubules, Proximal / drug effects; Liver / drug effects; Liver / metabolism; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Oxidants / toxicity; Oxidative Stress / drug effects
TL;DR:
The results suggest that organ-specific responses to oxidative stress by these potential prooxidant compounds may implicate a mechanism of their toxicities.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2016 journal article
Protein corona modulation of hepatocyte uptake and molecular mechanisms of gold nanoparticle toxicity
Nanotoxicology, 11(1), 64–75.
Contributors: K. Choi*, J. Riviere* & *
author keywords: Gold nanoparticles; human hepatocytes; cell uptake; cytochrome P450; mechanisms of action
MeSH headings : Albumins / chemistry; Blood Proteins / chemistry; Cell Survival / drug effects; Dose-Response Relationship, Drug; Gene Expression Profiling; Gold / chemistry; Gold / metabolism; Gold / toxicity; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / metabolism; Reactive Oxygen Species / metabolism; Transcriptome / drug effects
TL;DR:
Human hepatic uptake of 40 and 80 nm AuNP with branched polyethylenimine (BPEI), lipoic acid (LA) and polyethylene glycol (PEG) coatings as well as human plasma protein (HP) and human serum albumin (HSA) coronas was investigated to better understanding of the dramatic effect of protein coronas (PC) on AuNP cellular uptake, cytotoxicity and their underlying molecular mechanisms of action.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 27, 2021
2016 journal article
Quantification of nanoparticle pesticide adsorption: computational approaches based on experimental data
Nanotoxicology, 10(8), 1118–1128.
Contributors: R. Chen *, Y. Zhang *, * & J. Riviere*
author keywords: BSAI; in situ characterization; nanoparticles; pesticide; surface physicochemistry
MeSH headings : Adsorption; Models, Theoretical; Nanoparticles / analysis; Nanoparticles / chemistry; Neural Networks, Computer; Pesticides / analysis; Pesticides / chemistry; Principal Component Analysis; Surface Properties
TL;DR:
The first attempt of the application of such quantitative measures toward environmental endpoints by analyzing the interactions of a selected group of nanomaterials with a variety of pesticides was made and quantitative computational approaches support theApplication of BSAI modeling in the area of environmental contamINANt detection and remediation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2016 chapter
Safety of Nanoparticle Skin Penetration
In Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement (pp. 363–376).
TL;DR:
This review shows the skin is an important route of exposure to nanomaterials after occupational, environmental, and consumer product usage and there are many challenges that must be overcome before nanotechnology is applied to the field of nanomedicine and prior to conducting science-based occupational or environmental exposure risk assessments.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2016 journal article
Toxicological effects of pet food ingredients on canine bone marrow-derived mesenchymal stem cells and enterocyte-like cells
Journal of Applied Toxicology, 36(2), 189–198.
Contributors: M. Ortega*, B. Jeffery, J. Riviere* & *
author keywords: canine; bone marrow stem cells; enterocyte like cells; adult stem cell differentiation; essential oils; cytotoxicity; mesenchymal stem cells; in vitro
MeSH headings : Acrolein / analogs & derivatives; Acrolein / toxicity; Animal Feed / toxicity; Animals; Bone Marrow / drug effects; Citric Acid / toxicity; Clove Oil / toxicity; Cytotoxins / toxicity; Dogs; Enterocytes / drug effects; Eugenol / toxicity; Ginger / toxicity; Guanosine Monophosphate / toxicity; Inosine Monophosphate / toxicity; Mesenchymal Stem Cells / drug effects; Oils, Volatile / toxicity; Pets; Plant Oils / toxicity; Plant Roots / toxicity; Sorbose / toxicity; Thymol / toxicity
TL;DR:
These studies provide a baseline against which differential toxicity of dietary feed ingredients can be assessed in vitro for direct effects on canine cells and demonstrate differential toxicity in differentiated cells that represent gastrointestinal epithelial cells.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2015 journal article
Biomedical applications of gold nanomaterials: opportunities and challenges
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 7(6), 779–796.
Contributors: A. Sasidharan * & *
MeSH headings : Animals; Biocompatible Materials / chemistry; Biosensing Techniques; Cell Line, Tumor; Diagnostic Imaging; Drug Delivery Systems; Gold / chemistry; Humans; Immunoglobulin G / chemistry; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Nanomedicine / methods; Photochemistry; Photochemotherapy / methods; Spectrum Analysis, Raman; Surface Properties
TL;DR:
This review summarizes the recent research on the applications of AuNM with a focus on biomedical diagnostics and therapeutics and the bio-interaction of these NM with cells and their in vivo responses are presented.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 30, 2021
2015 journal article
Comparative In Vitro Cytotoxicity of 20 Potential Food Ingredients in Canine Liver, Kidney, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like Cells
Applied In Vitro Toxicology, 1(4), 276–288.
TL;DR:
Dose–response cytotoxicity studies and LC50 using alamar blue assays are reported for seven additional compounds: denatonium benzoate, eucalyptol, hexahydro isohumulone, tetrahydroisohumULone, green tea catechin extract, epigallocatechin gallate, and sodium copper chlorophyllin.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 30, 2021
2015 chapter
Dermatotoxicity of Nanomaterials
In B. Fadeel (Ed.), Handbook of Safety Assessment of Nanomaterials: From Toxicological Testing to Personalized Medicine (pp. 439–459,). Boca Raton, FL: Jenny Stanford Publishing.
Ed(s): B. Fadeel
Source: NC State University Libraries
Added: June 12, 2021
2015 journal article
Gold and silver nanoparticle interactions with human proteins: impact and implications in biocorona formation
Journal of Materials Chemistry B, 3(10), 2075–2082.
Contributors: A. Sasidharan *, J. Riviere* & *
TL;DR:
Findings suggest that irrespective of NP surface chemistry or chemical composition, corona proteins at their physiological concentrations interact rather differently; wherein HSA and IgG coronas adsorbed strongly on the NP surface and kept both Au and AgNP well dispersed, while fibrinogen caused rapid, strong and irreversible agglomeration.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 3, 2021
2015 chapter
In Vitro and In Vivo Toxicity and Pharmacokinetics of Silver Nanoparticles
In Encyclopedia of Nanotechnology (pp. 1–14).
Sources: Crossref, NC State University Libraries
Added: April 26, 2021
2015 journal article
In vitro safety assessment of food ingredients in canine renal proximal tubule cells
Toxicology in Vitro, 29(2), 289–298.
Contributors: J. Koči *, B. Jeffery, J. Riviere* & *
author keywords: Food ingredients; Canine; Proximal tubule cells; Lemongrass oil; Gene expression; Metabolic pathway
MeSH headings : Acrolein / analogs & derivatives; Acrolein / toxicity; Aminophenols / toxicity; Animals; Cell Survival / drug effects; Citric Acid / toxicity; Dogs; Eugenol / toxicity; Food Safety; Gene Expression Profiling; Ginger; Guanosine Monophosphate / toxicity; Humans; Inosine Monophosphate / toxicity; Kidney Tubules, Proximal / cytology; Oils, Volatile / toxicity; Plant Extracts / toxicity; Plant Oils / toxicity; Plant Roots; Sorbose / toxicity; Terpenes / toxicity; Thymol / toxicity; Thymus Plant; Toxicity Tests / methods; Xylitol / toxicity
TL;DR:
Viability assays along with mechanistic studies in the CPTC model may serve as a valuable in vitro toxicity screening tool.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 3, 2021
2015 journal article
Predicting the impact of biocorona formation kinetics on interspecies extrapolations of nanoparticle biodistribution modeling
Nanomedicine, 10(1), 25–33.
Contributors: F. Sahneh *, C. Scoglio *, * & J. Riviere*
author keywords: allometry; biocorona; interspecies extrapolation; in vitro-in vivo correlation; nanomaterials; nanoparticle biodistribution
MeSH headings : Animals; Humans; Kinetics; Mice; Models, Theoretical; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Pharmacokinetics; Rats; Surface Properties; Tissue Distribution
TL;DR:
While engineered NPs can successfully reach target cells in rodent models, the results may be different in humans due to the fact that the longer circulation time allows for further biocorona evolution.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 30, 2021
2015 journal article
Safety assessment of potential food ingredients in canine hepatocytes
Food and Chemical Toxicology, 78, 105–115.
Contributors: L. Zhang *, J. Koci *, B. Jeffery, J. Riviere* & *
MeSH headings : Acetaminophen / toxicity; Acrolein / analogs & derivatives; Acrolein / toxicity; Aflatoxin B1 / toxicity; Animal Feed / standards; Animals; Cell Line; Cell Survival / drug effects; Dogs; Down-Regulation; Eugenol / toxicity; Food Analysis; Food Safety; Ginger / chemistry; Ginger / toxicity; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Lethal Dose 50; Oils, Volatile / toxicity; Plant Extracts / toxicity; Plant Oils / toxicity; Plant Roots / chemistry; Plant Roots / toxicity; Rats; Terpenes / toxicity; Thymol / toxicity; Up-Regulation; Xylitol / toxicity
TL;DR:
In vitro assays such as this may be useful for hazard assessment of food ingredients for altered hepatic function, which CYP and heat shock most affected.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 30, 2021
2014 chapter
Dermal Exposure and Absorption of Chemicals and Nanomaterials
In Reference Module in Biomedical Sciences.
Sources: Crossref, NC State University Libraries
Added: May 30, 2021
2014 journal article
Growth of Zircone on Nanoporous Alumina Using Molecular Layer Deposition
JOM, 66(4), 649–653.
Contributors: R. Hall*, S. George *, Y. Kim*, W. Hwang*, M. Samberg n, n , R. Narayan n
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
In Vitro Biocompatibility and Antibacterial Efficacy of a Degradable Poly(L-lactide-co-epsilon-caprolactone) Copolymer Incorporated with Silver Nanoparticles
ANNALS OF BIOMEDICAL ENGINEERING, 42(7), 1482–1493.
Contributors: M. Samberg n, P. Mente n, T. He n, M. King n & n
author keywords: Nanoparticle; Keratinocyte; Skin tissue engineering; Scaffold; Biocompatibility
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biodegradable Plastics / chemistry; Biodegradable Plastics / pharmacology; Cell Proliferation / drug effects; Epidermal Cells; Epidermis / metabolism; Humans; Keratinocytes / cytology; Keratinocytes / metabolism; Materials Testing; Metal Nanoparticles / chemistry; Polyesters / chemistry; Polyesters / pharmacology; Silver / chemistry; Silver / pharmacology; Tissue Engineering
TL;DR:
Findings suggest that a scaffold containing between 0.5 and 1.0 mg(Ag) g(scaffold)−1 is both biocompatible and antibacterial, and is suitable for skin tissue engineering graft scaffolds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Nanoparticle Surface Characterization and Clustering through Concentration-Dependent Surface Adsorption Modeling
ACS Nano, 8(9), 9446–9456.
Contributors: R. Chen, Y. Zhang, F. Darabi Sahneh, C. Scoglio, W. Wohlleben *, A. Haase *, * , J. Riviere*
author keywords: BSAI; nanoparticles; nanomedicine; nanotoxicology surface physicochemistry; in situ characterization
MeSH headings : Adsorption; Models, Molecular; Nanoparticles / chemistry; Surface Properties
TL;DR:
The approach beyond the application of five descriptors in the original BSAI to address the concentration dependence of the descriptors, enabling better prediction of the adsorption profile and more accurate categorization of nanomaterials based on their surface properties is advanced.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: June 12, 2021
2014 book
Sources: Crossref, NC State University Libraries
Added: June 12, 2021
2014 journal article
Pharmacokinetics of metallic nanoparticles
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 7(2), 189–217.
Contributors: Z. Lin *, * & J. Riviere*
MeSH headings : Animals; Humans; Metal Nanoparticles / chemistry; Models, Biological; Pharmacokinetics
TL;DR:
Physiologically based pharmacokinetic models for gold/dendrimer composite nanodevices, AgNPs, and TiO2 NP models have been developed in rats and extrapolated to humans to support risk assessment and nanomedicine applications.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 30, 2021
2014 chapter
Safety Implications of Nanomaterial Exposure to Skin
In N. A. Monteiro-Riviere & C. L. Tran (Eds.), Nanotoxicology: Progress toward nanomedicine (2nd ed., pp. 267–292).
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: June 12, 2021
2014 chapter
Silver Nanoparticles in Biomedical Applications
In N. A. Monteiro-Riviere & C. Lang Tran (Eds.), Nanotoxicology: Progress toward Nanomedicine (2nd ed., pp. 425–442).
Sources: Crossref, NC State University Libraries
Added: June 12, 2021
2014 journal article
Two-photon polymerization/micromolding of microscale barbs for medical applications
Journal of Adhesion Science and Technology, 28(3-4), 387–398.
Contributors: R. Boehm n, B. Chen n, S. Gittard n, B. Chichkov n, n , A. Nasir*, R. Narayan n
author keywords: tissue barb; wound sealant; two-photon polymerization; micromolding; indirect rapid prototyping
TL;DR:
The results suggest that two-photon polymerization/micromolding is an indirect rapid prototyping approach that may be used for high-throughput replication of tissue barbs and other microstructured solid wound sealants.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2013 journal article
Biocompatibility analysis of an electrically-activated silver-based antibacterial surface system for medical device applications
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 24(3), 755–760.
Contributors: M. Samberg n, Z. Tan*, n , P. Orndorff n & R. Shirwaiker*
MeSH headings : Anti-Bacterial Agents; Biocompatible Materials; Equipment and Supplies; Escherichia coli / drug effects; Microbial Sensitivity Tests; Silver; Staphylococcus aureus / drug effects; Surface Properties
TL;DR:
The study concluded that the technological applications of the surface system for medical devices and surgical tools, which contact human tissues for less than 1.5 h, are expected to be self-sterilizing without causing toxicity in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Computational approaches and metrics required for formulating biologically realistic nanomaterial pharmacokinetic models
Computational Science & Discovery, 6(1), 014005.
Sources: Crossref, NC State University Libraries, ORCID
Added: June 12, 2021
2013 review
Nanomaterials and synergistic low-intensity direct current (LIDC) stimulation technology for orthopedic implantable medical devices
[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 5(3), 191–204.
Contributors: R. Shirwaiker n , M. Samberg n, P. Cohen n , R. Wysk n & n
MeSH headings : Animals; Electric Stimulation / methods; Equipment and Supplies; Humans; Nanostructures / therapeutic use; Nanostructures / ultrastructure; Nanotechnology / methods; Orthopedics; Prostheses and Implants
TL;DR:
While many nanomaterials have clearly demonstrated their ability to provide more effective implantable medical surfaces, further decisive investigations are necessary before they can translate into medically safe and commercially viable clinical applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Oxidative Stress and Dermal Toxicity of Iron Oxide Nanoparticles In Vitro
CELL BIOCHEMISTRY AND BIOPHYSICS, 67(2), 461–476.
Contributors: A. Murray*, E. Kisin*, A. Inman n, S. Young*, M. Muhammed*, T. Burks*, A. Uheida*, A. Tkach*
author keywords: Nanoparticles; Skin exposure; Ultraviolet radiation; Iron oxide
MeSH headings : Biological Transport; Cell Survival / drug effects; Cytokines / metabolism; Glutathione / metabolism; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; L-Lactate Dehydrogenase / metabolism; Magnetite Nanoparticles / chemistry; Magnetite Nanoparticles / toxicity; NF-kappa B / metabolism; Oxidative Stress / drug effects; Particle Size; Skin / cytology; Skin / drug effects; Transcription Factor AP-1 / metabolism
TL;DR:
Data indicate that co-exposure to UVB and SPIONs was associated with induction of oxidative stress and release of inflammatory mediators, verifying the need to thoroughly evaluate the adverse effects of UVB when evaluating dermal toxicity of engineered NPs on skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 review
Predicting skin permeability from complex vehicles
[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 65(2), 265–277.
Contributors: D. Karadzovska n, J. Brooks n, n & J. Riviere n
author keywords: Chemical mixtures; Formulations; Percutaneous/dermal absorption; Quantitative structure-permeation relationship (QSPR); QSAR; Linear free energy relationships (LFER); Mixture factor; Topical drug delivery enhancers
MeSH headings : Animals; Drug Delivery Systems; Humans; Linear Energy Transfer; Models, Theoretical; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / metabolism; Pharmaceutical Vehicles / chemistry; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption
TL;DR:
This review highlights the progress made in predicting skin permeability from complex vehicles by extending the use of quantitative structure-permeation relationship (QSPR) models based on linear free energy relationships (LFER) to predict dermal absorption from complex mixtures with the inclusion of significant molecular descriptors such as a mixture factor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Protein binding modulates the cellular uptake of silver nanoparticles into human cells: Implications for in vitro to in vivo extrapolations?
TOXICOLOGY LETTERS, 220(3), 286–293.
Contributors: n , M. Samberg n, S. Oldenburg* & J. Riviere n
author keywords: Protein corona; Protein binding of nanoparticles; Cellular uptake of silver nanoparticles; Albumin cell uptake; Transferrin cell uptake; IgG cell uptake
MeSH headings : Humans; Immunoglobulin G / metabolism; Keratinocytes / metabolism; Metal Nanoparticles / chemistry; Microscopy, Electron, Transmission; Protein Binding; Serum Albumin / metabolism; Silver / metabolism; Transferrin / metabolism
TL;DR:
NP association with different serum proteins, purportedly forming different protein coronas, significantly modulates Ag uptake into HEK compared to native NP uptake, suggesting caution in extrapolating in vitro uptake data to predict behavior in vivo where the nature of the protein corona may determine patterns of cellular uptake, and thus biodistribution, biological activity and toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 chapter
Skin Penetration of Engineered Nanomaterials
In E. A. Nasir, A. Friedman, & S. Wang (Eds.), Nanotechnology in Dermatology (Vol. 9781461450344, pp. 51–61).
Ed(s): E. Nasir, A. Friedman & S. Wang
TL;DR:
This chapter is to depict how skin can serve as a potential route of exposure to several types of nanomaterials, and will discuss how size, shape, charge, surface properties, and vehicles can be important determinants on the penetration through the rate-limiting lipid barrier of the stratum corneum.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: June 12, 2021
2013 journal article
The effects of geometry on skin penetration and failure of polymer microneedles
JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY, 27(3), 227–243.
Contributors: S. Gittard n, B. Chen n, H. Xu n, A. Ovsianikov *, B. Chichkov *, n , R. Narayan n
author keywords: microneedle; micromolding; acrylate-based polymer; porcine skin
TL;DR:
Video captured during skin penetration revealed that microneedle penetration into the skin occurred by means of a series of insertions and not by Means of a single insertion event, shedding insight into the mechanisms of microneEDle penetration and failure, facilitating design improvements for polymer microneeds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Acute vascular effects of nanoparticle infusion in isolated perfused skin
Nanomedicine: Nanotechnology, Biology and Medicine, 8(4), 428–431.
Contributors: J. Riviere n, T. Leavens n , J. Brooks n & n
author keywords: Nanoparticles; Vascular toxicity; In vitro; Biodistribution
MeSH headings : Animals; Female; Perfusion; Quantum Dots; Skin / blood supply; Skin / pathology; Skin / physiopathology; Sus scrofa; Vascular Resistance / drug effects
TL;DR:
Specific nanoparticle infusions were demonstrated to be associated with significant acute vascular physiological effects, and these observations suggest certain nanoparticles infusions may beassociated with acute vascular physiologic effects that merit further attention.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Challenges obtaining a biowaiver for topical veterinary dosage forms
Journal of Veterinary Pharmacology and Therapeutics, 35(SUPPL. 1), 103–114.
Contributors: R. Baynes n, J. Riviere n, T. Franz, n , P. Lehman, M. Peyrou *, P. Toutain *
MeSH headings : Administration, Topical; Animals; Dosage Forms; Drug Administration Routes; Legislation, Drug; Species Specificity; Therapeutic Equivalency; Veterinary Drugs / administration & dosage; Veterinary Drugs / chemistry; Veterinary Drugs / pharmacokinetics
TL;DR:
The focus of this paper is to address several of the challenges associated with determining the BE of these locally acting drugs and critically examine the current technological advances that can act as a surrogate for clinical trials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, Crossref
Added: August 6, 2018
2012 chapter
Effects of Engineered Nanomaterials on Skin
In B. Fadeel, A. Pietroiusti, & A. Shvedova (Eds.), Adverse Effects of Engineered Nanomaterials : Exposure, Toxicology, and Impact on Human Health (pp. 185–207). Burlington: Elsevier Science.
Ed(s): B. Fadeel, A. Pietroiusti & A. Shvedova
Source: NC State University Libraries
Added: June 12, 2021
2012 journal article
Effects of eight nanoparticles of different sizes and shapes on human epidermal keratinocytes
Journal of Investigative Dermatology, 132, S52. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000302866900308&KeyUID=WOS:000302866900308
Source: ORCID
Added: June 27, 2019
2012 chapter
In Vitro and In Vivo Toxicity of Silver Nanoparticles
In E. B. Bhushan) (Ed.), Encyclopedia of Nanotechnology (pp. 1069–1077,). Heidelberg, Germany: Springer Verlag.
Ed(s): E. Bhushan)
Source: NC State University Libraries
Added: June 12, 2021
2012 journal article
In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps
JOURNAL OF APPLIED TOXICOLOGY, 32(11), 913–919.
Contributors: T. Leavens n , n , A. Inman n, J. Brooks n, S. Oldenburg* & J. Riviere n
author keywords: silver nanoparticles; biodistribution; skin
MeSH headings : Animals; Metal Nanoparticles / chemistry; Nanoparticles / chemistry; Perfusion; Silver / chemistry; Silver / pharmacokinetics; Skin / metabolism; Swine / metabolism; Tissue Distribution
TL;DR:
The objective of the present study was to quantify the local biodistribution of two types of Ag nanoparticles, Ag‐citrate and Ag‐silica, in the isolated perfused porcine skin flap (IPPSF), and found no detectable elimination of Ag from the system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
LACK OF HYDROXYLATED FULLERENE TOXICITY AFTER INTRAVENOUS ADMINISTRATION TO FEMALE SPRAGUE-DAWLEY RATS
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 75(7), 367–373.
Contributors: n , K. Linder n, A. Inman n, J. Saathoff n, X. Xia n & J. Riviere n
MeSH headings : Animals; Blood Chemical Analysis; Drug Administration Schedule; Female; Fullerenes / administration & dosage; Fullerenes / chemistry; Fullerenes / toxicity; Injections, Intravenous; Liver / drug effects; Lymphocytes / drug effects; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / toxicity; Rats; Rats, Sprague-Dawley; Thymus Gland / drug effects; Toxicity Tests, Acute; Urinalysis
TL;DR:
These experiments suggest that this fullerol was well tolerated after iv administration to rats, and no clinically significant chemistry changes were observed after treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Quantum dot penetration into viable human skin
NANOTOXICOLOGY, 6(2), 173–185.
Contributors: T. Prow *, n , A. Inman n, J. Grice *, X. Chen *, X. Zhao *, W. Sanchez*, A. Gierden*
author keywords: Nanoparticles; exposure; nanotoxicology; surface chemistry
MeSH headings : Diffusion Chambers, Culture; Female; Humans; Hydrogen-Ion Concentration; Microscopy, Confocal; Nanoparticles; Particle Size; Polyethylene Glycols / metabolism; Polyethylene Glycols / pharmacology; Quantum Dots; Skin / chemistry; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Tissue Culture Techniques
TL;DR:
Systematic studies probing the effects of nanoparticle surface modification and formulation pH are important in nanotoxicology and nanomedicine and this study uses laser-scanning fluorescence confocal microscopy to evaluate nanoparticle penetration in viable excised human skin that was intact or tape-stripped.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Silver nanoparticles do not influence stem cell differentiation but cause minimal toxicity
NANOMEDICINE, 7(8), 1197–1209.
Contributors: M. Samberg n, E. Loboa n, S. Oldenburg* & n
author keywords: in vitro; nanoparticles; nanotechnology; nanotoxicology; scaffolds; silver; stem cells
MeSH headings : Adipose Tissue / cytology; Adult; Cell Differentiation / drug effects; Cell Survival / drug effects; Cells, Cultured; Female; Humans; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Silver / toxicity; Stem Cells / cytology; Stem Cells / drug effects; Young Adult
TL;DR:
The biocompatibility of Ag-NPs with both undifferentiated and differentiated hASC establishes their suitability for incorporation into tissue-engineered graft scaffolds, for the prevention of bacterial contamination upon implantation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 chapter
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 25, 2022
2012 journal article
Ultrananocrystalline Diamond-Coated Microporous Silicon Nitride Membranes for Medical Implant Applications
JOM, 64(4), 520–525.
Contributors: S. Skoog n, A. Sumant *, n & R. Narayan n
TL;DR:
The results show that the UNCD coating did not significantly alter the viability of human epidermal keratinocytes, indicating potential use of this material for improving skin sealing around percutaneous implants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Use of confocal microscopy for nanoparticle drug delivery through skin
Journal of Biomedical Optics, 18(6), 061214.
Contributors: L. Zhang * & *
author keywords: nanoparticles; confocal laser scanning microscopy; skin; keratinocytes
MeSH headings : Animals; Cell Line; Dendritic Cells / chemistry; Dendritic Cells / metabolism; Hair Follicle / chemistry; Hair Follicle / metabolism; Humans; Keratinocytes / chemistry; Keratinocytes / metabolism; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Microscopy, Confocal / methods; Quantum Dots; Silver / chemistry; Skin / chemistry; Skin / cytology; Skin / metabolism; Skin Absorption / drug effects; Skin Absorption / physiology; Swine
TL;DR:
The unique functions of CLSM such as the ability to detect fluorescence, optical sectioning, three dimensional remodeling, as well as its use in the reflection mode in tandem with other methods, provides great promise with broad applications regarding the interactions of nanomaterials with skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: May 30, 2021
2012 journal article
Zinc oxide - nanosize does not change the toxicological profile
Naunyn-Schmiedebergs Archives of Pharmacology, 385, 104. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000300779500460&KeyUID=WOS:000300779500460
Source: ORCID
Added: June 27, 2019
2011 journal article
Antibacterial efficacy of silver nanoparticles of different sizes, surface conditions and synthesis methods
NANOTOXICOLOGY, 5(2), 244–253.
Contributors: M. Samberg n, P. Orndorff n & n
author keywords: Silver; nanoparticles; nanotechnology; nanotoxicity; microbiology
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Escherichia coli / drug effects; Humans; Materials Testing; Metal Nanoparticles / chemistry; Metal Nanoparticles / ultrastructure; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Particle Size; Silver / chemistry; Silver / pharmacology; Staphylococcus aureus / drug effects; Surface Properties
TL;DR:
Silver nanoparticles are used as a natural biocide to prevent undesired bacterial growth in clothing and cosmetics to assess the antibacterial efficacy of Ag-nps of different sizes, surface conditions, and synthesis methods against Escherichia coli, Ag-resistant E. coli, methicillin-resistant S. aureus, and Salmonella sp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Atomic layer deposition of titanium dioxide on cellulose acetate for enhanced hemostasis
Biotechnology Journal, 6(2), 213–223.
Contributors: G. Hyde n, S. Stewart n, G. Scarel n, G. Parsons n , C. Shih*, C. Shih*, S. Lin*, Y. Su *, n , R. Narayan n
author keywords: Biomaterials; Cellulose; Hemocompatibility; Hemostatic agent; Titanium oxide
MeSH headings : Cell Survival / physiology; Cellulose / analogs & derivatives; Cellulose / chemistry; Cellulose / pharmacology; Hemostasis / drug effects; Humans; Microscopy, Electron, Scanning; Platelet-Rich Plasma / drug effects; Spectroscopy, Fourier Transform Infrared; Titanium / chemistry; Wettability
TL;DR:
The results suggest that atomic layer deposition is an appropriate method for improving the biological properties of hemostatic agents and other blood-contacting biomaterials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Cellular uptake mechanisms and toxicity of quantum dots in dendritic cells
NANOMEDICINE, 6(5), 777–791.
Contributors: L. Zhang n, W. Baeumer & *
author keywords: cellular uptake; dendritic cells; endocytosis; LPS; nanoparticles; quantum dot nanoparticles; scavenger receptor
MeSH headings : Animals; B7-1 Antigen / immunology; B7-2 Antigen / immunology; Cell Differentiation; Cell Survival; Cells, Cultured; Dendritic Cells / cytology; Dendritic Cells / immunology; Endocytosis; Granulocyte-Macrophage Colony-Stimulating Factor / immunology; Lipopolysaccharides / immunology; Monocytes / cytology; Monocytes / immunology; Quantum Dots; Swine
TL;DR:
Light is shed on the mechanism of QD655-COOH uptake in DCs and that cellular uptake pathways are dependent on cell type and cell differentiation, suggesting suppression with DC maturation.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 article
Commentary on transcutaneous delivery
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, Vol. 3, pp. 439–440.
TL;DR:
The article by Bolzinger, Briançon, and Chevalier in this issue of WIREs Nanomedicine and Nanobiotechnology focuses on addressing the apparent discrepancies in skin penetration of inorganic and organic nanoparticles used in cosmetics and pharmaceutical applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Deposition of antimicrobial coatings on microstereolithography-fabricated microneedles
JOM, 63(6), 59–68.
Contributors: S. Gittard n, P. Miller n, C. Jin n, T. Martin n, R. Boehm n, B. Chisholm*, S. Stafslien*, J. Daniels*
TL;DR:
It is indicated that light-based technologies, including visible light dynamic mask microstereolithography and pulsed laser deposition, may be used to fabricate microneedles with antimicrobial properties for treatment of local skin infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Dermal Penetration of UVB-Damaged Skin by Titanium- and Zincoxide Nanoparticles in Sunscreen Formulations
Naunyn-Schmiedebergs Archives of Pharmacology, 383, 101. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000288573100511&KeyUID=WOS:000288573100511
Source: ORCID
Added: June 27, 2019
2011 journal article
In vitro toxicity assessment of three hydroxylated fullerenes in human skin cells
TOXICOLOGY IN VITRO, 25(8), 2105–2112.
Contributors: J. Saathoff n, A. Inman n, X. Xia n, J. Riviere n & n
author keywords: Hydroxylated fullerenes; Fullerenes; Cytotoxicity; Skin cells; Keratinocytes; Nanoparticles
MeSH headings : Biological Transport; Cell Survival; Cells, Cultured; Fullerenes / chemistry; Fullerenes / metabolism; Fullerenes / toxicity; Humans; Hydroxylation; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / ultrastructure; Microscopy, Electron, Transmission; Photoelectron Spectroscopy; Spectrometry, Fluorescence
TL;DR:
Results suggest that different hydroxylation of fullerenes caused no cytotoxicity or inflammation up to 8.55 μg/ml, and suggest that extrapolation across similar NP will be dependent upon surface chemistry and concentration which may affect the degree of agglomeration and thus biological effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing
Biomicrofluidics, 5(1), 013415.
Contributors: P. Miller n, S. Gittard n, T. Edwards n, D. Lopez n, X. Xiao n, D. Wheeler n, n , S. Brozik n, R. Polsky n, R. Narayan n
TL;DR:
Carbon fiber electrodes were incorporated within a hollow microneedle array, which was fabricated using a digital micromirror device-based stereolithography instrument, and electrochemical measurements were demonstrated using integrated electrode-hollow micronedle devices.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, Crossref
Added: August 6, 2018
2011 journal article
Mapping the Surface Adsorption Forces of Nanomaterials in Biological Systems
ACS NANO, 5(11), 9074–9081.
Contributors: X. Xia n, n , S. Mathur *, X. Song *, L. Xiao*, S. Oldenberg*, B. Fadeel *, J. Riviere n
author keywords: engineered nanomaterials; surface adsorption; risk assessment; nanotoxicology; nanomedicine; nanomaterial characterization
MeSH headings : Adsorption; Biology; Nanostructures / chemistry; Surface Properties
TL;DR:
The BSAI nanodescriptors are intrinsic properties of nanomaterials useful for quantitative structure-activity relationship (QSAR) model development and could open a quantitative avenue in predictive nanomedicine development, risk assessment, and safety evaluation of nanmaterials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Modification of microneedles using inkjet printing
AIP Advances, 1(2), 022139.
Contributors: R. Boehm n, P. Miller n, S. Hayes n, n & R. Narayan n
TL;DR:
The results suggest that the combination of visible light dynamic mask micro-stereolithography-micromolding and inkjet printing enables fabrication of solid biodegradable microneedles with a widerange of geometries as well as a wide range of pharmacologic agent compositions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles
FARADAY DISCUSSIONS, 149, 171–185.
Contributors: S. Gittard n, P. Miller n, R. Boehm n, A. Ovsianikov *, B. Chichkov *, J. Heiser*, J. Gordon*, n , R. Narayan n
MeSH headings : Administration, Cutaneous; Animals; Drug Delivery Systems / instrumentation; Female; Humans; Infant, Newborn; Keratinocytes / chemistry; Microinjections / methods; Microscopy, Fluorescence; Needles; Polymers / chemistry; Quantum Dots; Skin / chemistry; Skin / cytology; Swine
TL;DR:
In this study, microneedle devices for transdermal drug delivery were fabricated by means of two-photon polymerization of an acrylate-based polymer to examine proliferation of cells on this polymer using neonatal human epidermal keratinocytes and human dermal fibroblasts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Safety Evaluation of Sunscreen Formulations Containing Titanium Dioxide and Zinc Oxide Nanoparticles in UVB Sunburned Skin: An In Vitro and In Vivo Study
TOXICOLOGICAL SCIENCES, 123(1), 264–280.
Contributors: n , K. Wiench*, R. Landsiedel *, S. Schulte *, A. Inman n & J. Riviere n
author keywords: sunscreens; sunburn skin; titanium dioxide (TiO2); zinc oxide (ZnO); nanoparticles; skin penetration
MeSH headings : Animals; Erythema / etiology; Erythema / pathology; Erythema / prevention & control; In Vitro Techniques; Metal Nanoparticles / radiation effects; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Particle Size; Skin / drug effects; Skin / pathology; Skin / radiation effects; Skin / ultrastructure; Sunburn / drug therapy; Sunburn / etiology; Sunburn / pathology; Sunscreening Agents / pharmacokinetics; Sunscreening Agents / toxicity; Swine / physiology; Titanium / pharmacokinetics; Titanium / radiation effects; Titanium / toxicity; Ultraviolet Rays / adverse effects; Zinc Oxide / pharmacokinetics; Zinc Oxide / radiation effects; Zinc Oxide / toxicity
TL;DR:
UVB-damaged skin slightly enhanced TiO(2) NP or ZnO NP penetration in sunscreen formulations but no transdermal absorption was detected.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 chapter
Absorption, Penetration, and Cutaneous Toxicity of Jet Fuels and Hydrocarbon Components
In Jet Fuel Toxicology (pp. 119–134).
Sources: Crossref, NC State University Libraries
Added: June 12, 2021
2010 chapter
Absorption, penetration, and cutaneous toxicity of jet fuels and hydrocarbon components
In Jet Fuel Toxicology (pp. 119–134).
Source: ORCID
Added: September 25, 2022
2010 journal article
An index for characterization of nanomaterials in biological systems
Nature Nanotechnology, 5(9), 671–675.
Contributors: X. Xia n, n & J. Riviere n
MeSH headings : Adsorption; Hormones / chemistry; Models, Chemical; Nanostructures / chemistry; Nanotubes, Carbon / chemistry; Proteins / chemistry; Small Molecule Libraries / chemistry; Steroids / chemistry
TL;DR:
The method successfully predicted the adsorption of various small molecules onto carbon nanotubes, and the nanodescriptors can be used to develop pharmacokinetic and safety assessment models for nanomaterials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2010 journal article
Atomic layer deposition of nanoporous biomaterials
MATERIALS TODAY, 13(3), 60–64.
Contributors: R. Narayan n, S. Adiga*, M. Pellin*, L. Curtiss *, S. Stafslien*, B. Chisholm*, n , R. Brigmon*, J. Elam *
TL;DR:
The results suggest that atomic layer deposition is an attractive technique for modifying the surfaces of nanoporous alumina membranes and other nanostructured biomaterials.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Atomic layer deposition-based functionalization of materials for medical and environmental health applications
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 368(1917), 2033–2064.
Contributors: R. Narayan n, S. Adiga*, M. Pellin*, L. Curtiss *, A. Hryn *, S. Stafslien*, B. Chisholm*, C. Shih*
author keywords: atomic layer deposition; self-assembly; nanoporous alumina; antimicrobial; antifouling
MeSH headings : Adsorption; Aluminum Oxide / chemistry; Anti-Bacterial Agents / chemistry; Blood Platelets / metabolism; Coated Materials, Biocompatible / chemistry; Equipment Design; Escherichia coli / metabolism; Humans; Materials Testing; Nanostructures / chemistry; Nanotechnology / methods; Platinum / chemistry; Polyethylene Glycols / chemistry; Staphylococcus aureus / metabolism; Zinc Oxide / chemistry
TL;DR:
The results of this work indicate that nanoporous alumina membranes may be modified using atomic layer deposition for use in a variety of medical and environmental health applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
CYTOKINE AND CHEMOKINE LEVELS IN SERUM AND CEREBROSPINAL FLUID OF DOGS WITH INFLAMMATORY CENTRAL NERVOUS SYSTEM DISEASE
Journal of Veterinary Internal Medicine, 24(3), 741. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000277416600262&KeyUID=WOS:000277416600262
Contributors: C. Mariani, L. Boozer, G. Cherubini, K. Vernau, J. Campbell, S. Dillard, P. Early, R. Gallagher
Source: ORCID
Added: June 27, 2019
2010 chapter
Characterization of Toxicoproteomics Maps for Chemical Mixtures Using Information Theoretic Approach
In Principles and Practice of Mixtures Toxicology (pp. 215–234).
Contributors: S. Basak *, B. Gute*, n & F. Witzmann*
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 30, 2021
2010 chapter
Dermal Exposure and Absorption of Chemicals and Nanomaterials*
In Comprehensive Toxicology (Vol. 1-14, pp. 111–122).
Contributors: J. Riviere n & n
TL;DR:
Techniques for quantitating skin permeability using this assumption and basic approaches to linking permeability to molecular properties using quantitative structure permeability relationships (QSPeR) are presented.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 30, 2021
2010 journal article
EVALUATION OF CYTOKINE AND CHEMOKINE LEVELS IN CANINE INTRACRANIAL NEOPLASIA
Journal of Veterinary Internal Medicine, 24(3), 741. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000277416600264&KeyUID=WOS:000277416600264
Contributors: L. Boozer, C. Mariani, J. Campbell, S. Dillard, P. Early, R. Gallagher, E. MacKillop, K. Munana
Source: ORCID
Added: June 27, 2019
2010 chapter
Evaluating the risks associated with nanomaterials
In E. A. V. Narlikar & Y. Y. Du (Eds.), The Oxford Handbook of Nanoscience and Technology, Frontiers and Advances: Vol. III (pp. 888–906,). Oxford: Oxford University Press.
Ed(s): E. Narlikar & Y. Du
Source: NC State University Libraries
Added: June 12, 2021
2010 journal article
Evaluation of Silver Nanoparticle Toxicity in Skin in Vivo and Keratinocytes in Vitro
ENVIRONMENTAL HEALTH PERSPECTIVES, 118(3), 407–413.
Contributors: M. Samberg n, S. Oldenburg* & n
author keywords: keratinocytes; metal oxides; nanoparticles; nanotechnology; porcine skin; silver; skin penetration; toxicity
MeSH headings : Animals; Cell Survival / drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Humans; Inflammation / chemically induced; Inflammation / metabolism; Inflammation / pathology; Interleukins / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / toxicity; Particle Size; Silver / administration & dosage; Silver / toxicity; Skin / cytology; Skin / drug effects; Skin / metabolism; Swine; Time Factors; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
A better understanding of Ag-nps safety in vitro as well as in vivo is provided and a basis for occupational and risk assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles
TOXICOLOGY LETTERS, 197(1), 1–6.
Contributors: T. Leavens n , X. Xia n, H. Lee n, n , J. Brooks n & J. Riviere n
author keywords: nC(60); Isolated perfused porcine skin flaps; Pharmacokinetics; In vitro; Nanoparticles; Skin
MeSH headings : Animals; Arteries / metabolism; Colloids; Female; Fullerenes / pharmacokinetics; Immunoglobulin G / metabolism; Models, Animal; Nanoparticles / ultrastructure; Skin / metabolism; Swine; Tissue Distribution; Veins / metabolism
TL;DR:
Based on the apparent volume of distribution, the low extraction during the perfusion, and the high percentage recovery following the washout phase, there was limited distribution of fullerene nanoparticles from the vascular space into the extracellular space and negligible intracellular uptake of nC(60) in this system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Fabrication of Microneedles Using Two Photon Polymerization for Transdermal Delivery of Nanomaterials
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 10(10), 6305–6312.
Contributors: A. Doraiswamy n, A. Ovsianikov, S. Gittard*, * , R. Crombez, E. Montalvo, W. Shen, B. Chichkov, R. Narayan*
author keywords: Microneedle; Transdermal Drug Delivery; Rapid Prototyping; Nanomaterials; Human Epidermal Keratinocytes
MeSH headings : Administration, Cutaneous; Animals; Biocompatible Materials / administration & dosage; Biocompatible Materials / chemistry; Cell Survival / drug effects; Cells, Cultured; Drug Delivery Systems / instrumentation; Elastic Modulus; Equipment Design; Female; Hardness; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Materials Testing; Microscopy, Confocal; Microscopy, Electron, Scanning; Microtechnology / methods; Nanostructures / administration & dosage; Needles; Polymerization; Quantum Dots; Skin / drug effects; Skin / metabolism; Swine
TL;DR:
Microneedies were shown to enable more rapid distribution of the PEG-amine quantum dot solution to the deep epidermis and dermis layers of porcine skin than topical administration and suggest that two photon polymerization may be used to create microneedle arrays for transdermal delivery of nanoscale pharmacologic agents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
In vitro biocompatibility of titanium alloy discs made using direct metal fabrication
MEDICAL ENGINEERING & PHYSICS, 32(6), 645–652.
Contributors: C. Haslauer n, J. Springer n, O. Harrysson n , E. Loboa n, n & D. Marcellin-Little n
author keywords: Biocompatibility; Orthopedic implant; Free-form fabrication; Direct metal fabrication; Electron beam melting; Stem cell; Human stem cell
MeSH headings : Adipose Tissue / cytology; Alloys / chemical synthesis; Alloys / chemistry; Alloys / pharmacology; Aluminum / chemistry; Cell Proliferation / drug effects; Cell Survival / drug effects; Female; Humans; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Materials Testing / methods; Middle Aged; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / metabolism; Surface Properties; Titanium / chemistry; Titanium / pharmacology; Vanadium / chemistry
TL;DR:
In vitro biocompatibility of EBM titanium-6 aluminum-4 vanadium (Ti6Al4V) structures is assessed by comparing the cellular response to solid polished, solid unpolished, and porous EBM discs to the Cellular response to discs made of commercially produced Ti6Al 4V.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Interactions of aluminum nanoparticles with human epidermal keratinocytes
JOURNAL OF APPLIED TOXICOLOGY, 30(3), 276–285.
Contributors: n , S. Oldenburg* & A. Inman n
author keywords: aluminum; nanoparticles; human epidermal keratinocytes; nanotoxicity; viability assays; cytokine
MeSH headings : Aluminum / analysis; Aluminum / chemistry; Aluminum / toxicity; Artifacts; Cell Survival / drug effects; Cells, Cultured; Humans; Indicators and Reagents / chemistry; Inflammation Mediators / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / ultrastructure; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Microscopy, Electron, Transmission; Osmolar Concentration; Particle Size; Reproducibility of Results; Spectrophotometry; Temperature; Vacuoles / ultrastructure
TL;DR:
The difficulties involved in assessing the biological safety of nanomaterials such as Al NP due to media‐ and temperature‐dependent particle agglomeration and nanoparticle interactions with biomarkers of cytotoxicity are illustrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Intrinsic biological property of colloidal fullerene nanoparticles (nC(60)): Lack of lethality after high dose exposure to human epidermal and bacterial cells
TOXICOLOGY LETTERS, 197(2), 128–134.
Contributors: X. Xia n, n & J. Riviere n
author keywords: Water-soluble fullerenes; Nanotoxicity; Fullerene nanoparticles; Bacteria toxicity; Human epidermal keratinocytes
MeSH headings : Bacillus subtilis / drug effects; Epidermal Cells; Escherichia coli / drug effects; Fullerenes / chemistry; Fullerenes / toxicity; Humans; Keratinocytes / drug effects; Microbial Sensitivity Tests; Nanoparticles / chemistry; Nanoparticles / toxicity; Particle Size; Toxicity Tests
TL;DR:
A novel method for preparing nC60 nanoparticles that does not use THF solvent, but provides nC 60 with an average particle size of 43.8 nm and a yield approximately 100 times higher than the THF method is reported, confirming the prior non-toxic reports when using nC50 prepared with non-THF methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Lectins modulate multi-walled carbon nanotubes cellular uptake in human epidermal keratinocytes
TOXICOLOGY IN VITRO, 24(2), 546–551.
Contributors: L. Zhang n & n
author keywords: Nanomaterials; Multi-walled carbon nanotubes; Lectins; Endocytic pathways; Melanosome transfer pathway; Cellular uptake
MeSH headings : Epidermal Cells; Humans; Keratinocytes / drug effects; Keratinocytes / metabolism; Lotus / chemistry; Solanum lycopersicum / chemistry; Microscopy, Electron, Transmission; Nanotubes, Carbon / ultrastructure; Peas / chemistry; Plant Lectins / pharmacology
TL;DR:
Lectins are inhibitors of the melanosome transfer pathway was used to study the uptake of MWCNT in keratinocytes, to see if they played a role in reducing the cellular uptake of carbon nanotubes in HEK, and studies confirmed that lectin cocktails decreased M WCNT interaction at the cell surface and uptake.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 chapter
Nanomaterial penetration
In Toxicology of the Skin (pp. 333–346). http://www.scopus.com/inward/record.url?eid=2-s2.0-77958477177&partnerID=MN8TOARS
Source: ORCID
Added: September 25, 2022
2010 chapter
Potential Arsenic Exposure Through Dermal Penetration
In N. A. Monteiro-Riviere) (Ed.), Toxicology of the Skin (pp. 347–360). http://www.scopus.com/inward/record.url?eid=2-s2.0-85056392662&partnerID=MN8TOARS
Ed(s): N. Monteiro-Riviere)
Sources: NC State University Libraries, ORCID
Added: June 12, 2021
2010 book
Preface
In Toxicology of the Skin (p. v). http://www.scopus.com/inward/record.url?eid=2-s2.0-85060190964&partnerID=MN8TOARS
Source: ORCID
Added: September 25, 2022
2010 journal article
Skin penetration and kinetics of pristine fullerenes (C-60) topically exposed in industrial organic solvents
TOXICOLOGY AND APPLIED PHARMACOLOGY, 242(1), 29–37.
Contributors: X. Xia n, n & J. Riviere n
author keywords: Dermal absorption; Stratum corneum; Nanomaterials; Fullerenes; Solvent effects; Nanotoxicity
MeSH headings : Algorithms; Animals; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Fullerenes / pharmacokinetics; Fullerenes / toxicity; Occupational Exposure / adverse effects; Particle Size; Skin / chemistry; Skin / pathology; Skin Absorption; Solvents / chemistry; Swine
TL;DR:
The solvent effects on the stratum corneum absorption of C60 were consistent with those observed in vivo; in vitro flow-through diffusion cell experiments were conducted in pig skin and fullerenes were not detected in the receptor solutions by 24 h.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 chapter
Structure and Function of Skin
In N. A. Monteiro-Riviere (Ed.), Toxicology of the Skin (pp. 1–18,). http://www.scopus.com/inward/record.url?eid=2-s2.0-85056380325&partnerID=MN8TOARS
Sources: NC State University Libraries, ORCID
Added: June 12, 2021
2010 book
Toxicology of the skin
In Toxicology of the Skin (pp. 1–437). http://www.scopus.com/inward/record.url?eid=2-s2.0-84868687035&partnerID=MN8TOARS
Source: ORCID
Added: September 25, 2022
2010 journal article
Two Photon Polymerization-Micromolding of Polyethylene Glycol-Gentamicin Sulfate Microneedles
ADVANCED ENGINEERING MATERIALS, 12(4), B77–B82.
Contributors: S. Gittard n, A. Ovsianikov *, H. Akar*, B. Chichkov *, n , S. Stafslien*, B. Chisholm*, C. Shin*
TL;DR:
In this study, a photopolymerization‐micromolding technique was used to fabricate microneedle arrays from a photosensitive material containing polyethylene glycol 600 diacrylate, gentamicin sulfate, and a photoinitiator that inhibited growth of Staphylococcus aureus bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
ASSESSMENT OF QUANTUM DOT PENETRATION INTO SKIN IN DIFFERENT SPECIES UNDER DIFFERENT MECHANICAL ACTIONS
Nanomaterials: Risks and Benefits, 43–52.
TL;DR:
Results indicate that porcine skin penetration of QD621 is minimal and limited primarily to the outer SC layers, while QD565 and 655 penetrated into the dermis of abraded skin and skin is an important organ and can serve as a potential route of exposure and should be overlooked.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: June 27, 2019
2009 journal article
Assessing the antimicrobial activity of zinc oxide thin films using disk diffusion and biofilm reactor
APPLIED SURFACE SCIENCE, 255(11), 5806–5811.
Contributors: S. Gittard n, J. Perfect *, n , W. Wei n, C. Jin n & R. Narayan n
author keywords: Antimicrobial materials; Pulsed laser deposition; Zinc oxide
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Atomic layer deposition of TiO2 thin films on nanoporous alumina templates: Medical applications
JOM, 61(6), 12–16.
Contributors: R. Narayan n, n , R. Brigmon*, M. Pellin* & J. Elam *
TL;DR:
Atomic layer deposition was used to coat all the surfaces of a nanoporous alumina membrane in order to reduce the pore size in a controlled manner, and neither the 20 nm nor the 100 nm TiO2-coated nanoporus alumina membranes exhibited statistically lower viability compared to the uncoated nano-structure-based membrane control materials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Comparison of Quantum Dot Biodistribution with a Blood-Flow-Limited Physiologically Based Pharmacokinetic Model
Nano Letters, 9(2), 794–799.
Contributors: H. Lee n, T. Leavens n, S. Mason n, n & J. Riviere n
MeSH headings : Animals; Hemodynamics; Mice; Models, Biological; Organ Specificity; Pharmacokinetics; Quantum Dots; Rats; Tissue Distribution
TL;DR:
The physiologically based pharmacokinetic model predicted the experimentally observed persistence of QDs in tissues but not early time profiles or different QD biodistribution, suggesting more complex models will be needed to better predict QD biodiversity in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Comparison of quantum dot biodistribution with a blood-flow-limited physiologically based pharmacokinetic model
Nano Letters, 9(2), 794–799.
Source: ORCID
Added: September 25, 2022
2009 entry reference
Cutaneous Toxicology
Sources: Crossref, NC State University Libraries
Added: May 30, 2021
2009 journal article
Endocytic mechanisms and toxicity of a functionalized fullerene in human cells
TOXICOLOGY LETTERS, 191(2-3), 149–157.
Contributors: L. Zhang n, J. Yang *, A. Barron * & n
author keywords: Derivatized fullerene; Endocytosis; Cytotoxicity; Human epidermal keratinocytes; Cellular uptake; Nanoparticle
MeSH headings : Adenosine Triphosphate / metabolism; Cell Line; Cell Proliferation / drug effects; Cell Survival / drug effects; Coloring Agents; Drug Delivery Systems; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Fullerenes / chemistry; Fullerenes / toxicity; Humans; Lysosomes / drug effects; Microscopy, Confocal; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Models, Molecular; Spectrophotometry, Ultraviolet; Tetrazolium Salts; Thiazoles
TL;DR:
Results showed that the endocytic pathways could be mediated by caveolae/lipid rafts and cytoskeletal components and a scavenger receptor inhibitor completely blocked the uptake of Baa-Lys(FITC)-(Lys)(8)-OH, suggesting a specific endocytics pathway was strongly involved in Baa(F ITC)- (Lys)8-OH cellular uptake.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Expression of Proinflammatory Cytokines by Human Mesenchymal Stem Cells in Response to Cyclic Tensile Strain
JOURNAL OF CELLULAR PHYSIOLOGY, 219(1), 77–83.
Contributors: R. Sumanasinghe n, T. Pfeiler n, n & E. Loboa n
MeSH headings : Animals; Bone Marrow Cells / cytology; Bone Marrow Cells / physiology; Cells, Cultured; Cytokines / metabolism; Humans; Interleukin-1beta / metabolism; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Stress, Mechanical; Stress, Physiological; Tensile Strength; Tumor Necrosis Factor-alpha / metabolism; Young Adult
TL;DR:
IL‐6 and IL‐8 expressions by hMSCs were induced by cyclic tensile strain and osteogenic differentiating media, indicating that IL‐ 6 andIL‐8 may be functioning as autocrine signals during osteogenic differentiation of h MSCs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Fabrication of Polymer Microneedles Using a Two-Photon Polymerization and Micromolding Process
Journal of Diabetes Science and Technology, 3(2), 304–311.
Contributors: S. Gittard n, A. Ovsianikov*, n , J. Lusk*, P. Morel *, P. Minghetti *, C. Lenardi *, B. Chichkov*, R. Narayan n
MeSH headings : Administration, Cutaneous; Biocompatible Materials; Diabetes Mellitus / drug therapy; Dimethylpolysiloxanes / chemistry; Drug Delivery Systems / instrumentation; Humans; Insulin / administration & dosage; Microtechnology / methods; Needles; Polymethacrylic Acids / chemical synthesis
TL;DR:
The results suggest that a 2PP microfabrication and subsequent PDMS micromolding process may be used to create microneedle structures with appropriate structural, mechanical, and biological properties for transdermal drug delivery of insulin and other protein-based pharmacologic agents for treatment of diabetes mellitus.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 30, 2021
2009 chapter book
Human Health Risks of Engineered Nanomaterials
Contributors: A. Elder*, I. Lynch *, K. Grieger* , S. Chan-Remillard*, A. Gatti *, H. Gnewuch*, E. Kenawy *, R. Korenstein*
TL;DR:
This Working Group report summarizes the discussions of an expert scientific panel regarding the gaps in knowledge that impede effective human health risk assessment for nanomaterials, particularly those that are suspended in a gas or liquid and, thus, deposit on skin or in the respiratory tract.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: June 27, 2019
2009 chapter
Human health risks of engineered nanomaterials
In Nanomaterials: Risks and benefits (pp. 1–28). Dordrecht, Holland: Springer.
Ed(s): I. Linkov & J. Steevens
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Interaction of nanomaterials with skin: Aspects of absorption and biodistribution
Nanotoxicology, 3(3), 188–193.
Contributors: n & J. Riviere n
author keywords: Absorption; biodistribution; nanomaterials; penetration; skin; drug delivery; cosmetics; exposure; nanomedicine
TL;DR:
Research is beginning to be conducted to define the mechanistic framework describing nanomaterials biodistribution using pharmacokinetic models, suggesting that absorption is minimal, yet particle characteristics and species differences exist.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line
TOXICOLOGY AND APPLIED PHARMACOLOGY, 234(2), 222–235.
author keywords: Carbon; Nanomaterials; Carbon black; Single-walled carbon nanotubes; C-60; nC(60); Quantum dots; Calcein AM; Live/Dead; NR; MTT; Celltiter 96 (R) AQueous One; Alamar Blue; Celltiter-Blue (R); CytoTox One (TM); Flow cytometry; Human epidermal keratinocytes; Toxicity; Viability assays
MeSH headings : Cell Line; Cell Survival / drug effects; Drug Evaluation, Preclinical; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Humans; Keratinocytes / drug effects; Light; Microscopy, Electron, Transmission; Nanoparticles / toxicity; Oxazines; Quantum Dots; Scattering, Radiation; Spectrophotometry, Ultraviolet; Tetrazolium Salts; Thiazoles; Trypan Blue; Xanthenes
TL;DR:
This study shows that, unlike small molecules, CNM interact with assay markers to cause variable results with classical toxicology assays and may not be suitable for assessing nanoparticle cytotoxicity, therefore, more than one assay may be required when determining nanoparticle toxicity for risk assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 article
Mechanisms of Quantum Dot Nanoparticle Cellular Uptake
Zhang, L. W., & Monteiro-Riviere, N. A. (2009, July). TOXICOLOGICAL SCIENCES, Vol. 110, pp. 138–155.
Contributors: L. Zhang n & n
author keywords: quantum dot nanoparticles; endocytosis; lipid rafts; G-protein-coupled receptor; scavenger receptor; cytotoxicity
MeSH headings : Actins / metabolism; Cell Membrane / metabolism; Cell Membrane / ultrastructure; Cells / drug effects; Cells / metabolism; Cytoplasm / metabolism; Cytoplasm / ultrastructure; Cytoskeleton / drug effects; Endosomes / drug effects; Flow Cytometry; Free Radical Scavengers / pharmacology; Humans; Immunohistochemistry; Indicators and Reagents; Keratinocytes / drug effects; Lysosomes / metabolism; Lysosomes / ultrastructure; Membrane Microdomains / drug effects; Membrane Potentials / drug effects; Microscopy, Confocal; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Pinocytosis / drug effects; Quantum Dots; Spectrometry, Fluorescence; Transport Vesicles / drug effects; Transport Vesicles / metabolism
TL;DR:
It is shown that QD with a carboxylic acid surface coating were recognized by lipid rafts but not by clathrin or caveolae in human epidermal keratinocytes (HEKs) and endocytic pathways are primarily regulated by the G-protein-coupled receptor associated pathway and low density lipoprotein receptor/scavenger receptor.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Microfabricated curtains for controlled cell seeding in high throughput microfluidic systems
LAB ON A CHIP, 9(12), 1756–1762.
Contributors: . Adrian T. O'Neill n, n & G. Walker n
MeSH headings : Cell Culture Techniques / instrumentation; Cell Movement; Cell Proliferation; Cell Survival / drug effects; Collagen / metabolism; Cytotoxins / toxicity; Dimethylpolysiloxanes; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Microfluidic Analytical Techniques / instrumentation; Nylons; Skin / cytology; Time Factors
TL;DR:
Curtain use permitted high initial cell seeding densities and increased the amount of time cells can be cultured compared to multi-well plates and showed that cells exposed to 6% ethanol or less grew in population size, 8% ethanol exposure stunted growth, and higher concentrations led to population loss.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Nanoporous membranes for medical and biological applications
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 1(5), 568–581.
Contributors: S. Adiga*, C. Jin*, L. Curtiss *, n & R. Narayan*
MeSH headings : Biomedical Technology / methods; Drug Delivery Systems / methods; Humans; Membranes, Artificial; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Nanotechnology / methods; Permeability; Porosity
TL;DR:
An overview of nanoporous membranes for biomedical applications, including biosensing, biosorting, immunoisolation, and drug delivery, are presented and desirable properties of membranes used in implantable devices, including biocompatibility and antibiofouling behavior are discussed.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Pulsed laser deposition of antimicrobial silver coating on Ormocer (R) microneedles
BIOFABRICATION, 1(4).
Contributors: S. Gittard n, R. Narayan n, C. Jin n, A. Ovsianikov *, B. Chichkov *, n , S. Stafslien*, B. Chisholm*
MeSH headings : Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Biotechnology; Cell Survival / drug effects; Ceramics / chemistry; Diffusion; Drug Delivery Systems / instrumentation; Humans; Keratinocytes; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Microtechnology / methods; Needles; Organically Modified Ceramics; Silanes / administration & dosage; Silanes / chemistry; Silver / administration & dosage; Silver / chemistry; Staphylococcus aureus / drug effects
TL;DR:
It is indicated that coating microneedles with silver thin films using pulsed laser deposition is a useful and novel approach for creating microneEDles with antimicrobial functionality.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Pulsed laser deposition of antimicrobial silver coating on Ormocer microneedles.
Biofabrication, 1(4), 041001. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:20661316&KeyUID=MEDLINE:20661316
Source: ORCID
Added: April 30, 2021
2009 journal article
Rapid prototyping of scaphoid and lunate bones
Biotechnology Journal, 4(1), 129–134.
Contributors: S. Gittard n, R. Narayan n, J. Lusk*, P. Morel *, F. Stockmans*, M. Ramsey*, C. Laverde*, J. Phillips*
MeSH headings : Analysis of Variance; Cell Survival; Compressive Strength; Computer-Aided Design; Elastic Modulus; Humans; Keratinocytes / metabolism; Lunate Bone / anatomy & histology; Materials Testing; Polymers / chemistry; Prostheses and Implants; Prosthesis Design / methods; Resins, Synthetic / chemistry; Scaphoid Bone / anatomy & histology; Tomography, X-Ray Computed
TL;DR:
The results of this study indicate that small bone prostheses fabricated by stereolithography using eShell 200 polymer may have suitable geometry, mechanical properties, and cytocompatibility properties for in vivo use.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 30, 2021
2009 book
Review of Federal Strategy for Nanotechnology-Related Environmental, Health, and Safety Research
Sources: Crossref, NC State University Libraries
Added: June 12, 2021
2009 journal article
Stretchable diamond-like carbon microstructures for biomedical applications
JOM, 61(9), 53–58.
Contributors: R. Boehm*, R. Narayan*, R. Aggarwal n, * & S. Lacour *
TL;DR:
The use of pulsed laser deposition is described to create diamond-like carbon microstructures on polydimethylsiloxane to demonstrate the viability of human epidermal keratinocyte cells onpolydimethyl Siloxane surfaces coated with arrays of diamond- like carbon islands.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 chapter
Anatomical factors that affect barrier function
In K. P. W. H. Zhai & H. I. Maibach (Eds.), Dematotoxicology (7th ed.) (pp. 39–50). Boca Raton: Wiley & Sons.
Ed(s): K. H. Zhai & H. Maibach
Source: NC State University Libraries
Added: August 6, 2018
2008 chapter
Animal skin morphology and dermal absorption
In M. S. Roberts & K. A. Walters (Eds.), Dermal absorption and toxicity assessment (2nd ed., pp. 17–35). New York: Informa Healthcare.
Ed(s): M. Roberts & K. Walters
Source: NC State University Libraries
Added: August 6, 2018
2008 article
Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin
SKIN PHARMACOLOGY AND PHYSIOLOGY, Vol. 21, pp. 166–180.
author keywords: quantum dots; nanoparticles; skin penetration; skin flexion; skin abrasion; tape-stripped skin
MeSH headings : Adhesives; Administration, Cutaneous; Animals; Dermabrasion; Microscopy, Confocal; Permeability; Quantum Dots; Rats; Rats, Wistar; Skin / metabolism; Skin Absorption; Spectrometry, Fluorescence
TL;DR:
The results indicate that the rat skin penetration of QD655 and QD565 is primarily limited to the uppermost stratum corneum layers of intact skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes
TOXICOLOGY AND APPLIED PHARMACOLOGY, 228(2), 200–211.
Contributors: L. Zhang n, W. Yu *, V. Colvin * & n
author keywords: quantum dot; nanoparticles; skin penetration; cytokines; keratinocytes; cellular uptake; inflammation; skin
MeSH headings : Animals; Cell Line; Cell Survival / drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Fluorescence; Fluorometry / methods; Humans; Hydrogen-Ion Concentration; Interleukins / metabolism; Keratinocytes / chemistry; Keratinocytes / drug effects; Keratinocytes / ultrastructure; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Particle Size; Polyethylene Glycols / chemistry; Quantum Dots; Receptor Protein-Tyrosine Kinases / metabolism; Receptor, EphA3; Spectrometry, Mass, Electrospray Ionization / methods; Swine; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Results indicate that porcine skin penetration of QD621 is minimal and limited primarily to the outer SC layers, yet if the skin were damaged allowing direct QD exposure to skin or keratinocytes, an inflammatory response could be initiated.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
COLL 95-Assessment of quantum dot nanoparticle penetration in human skin
Abstracts of Papers of the American Chemical Society, 236. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000270256303852&KeyUID=WOS:000270256303852
Source: ORCID
Added: June 27, 2019
2008 journal article
Characterization of microfluidic human epidermal keratinocyte culture
CYTOTECHNOLOGY, 56(3), 197–207.
Contributors: . Adrian T. O'Neill*, * & G. Walker*
author keywords: cytotoxicity; high-throughput; keratinocyte; microfluidic; PDMS; toxicology
TL;DR:
Human epidermal keratinocytes were shown to maintain 93.0%–99.6% viability at 72 h under medium perfusion ranging from 0.025–0.4 μl min−1, a level not possible in 96 well plates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Cyclic tensile strain increases interactions between human epidermal keratinocytes and quantum dot nanoparticles
TOXICOLOGY IN VITRO, 22(2), 491–497.
Contributors: J. Rouse n, C. Haslauer n, E. Loboa n & n
author keywords: quantum dot nanoparticles; keratinocytes; skin; tensile strain; cellular uptake
MeSH headings : Borates / toxicity; Cell Membrane Permeability / drug effects; Cell Survival / drug effects; Cells, Cultured; Cytokines / analysis; Cytokines / biosynthesis; Epidermal Cells; Epidermis / drug effects; Ethidium; Fluoresceins; Fluorescent Dyes; Humans; Keratinocytes / drug effects; Keratinocytes / physiology; Microscopy, Fluorescence; Pharmaceutical Vehicles / chemistry; Polyethylene Glycols / chemistry; Quantum Dots; Tensile Strength
TL;DR:
Application of physiological load conditions can increase cell membrane permeability, thereby increasing the concentration of QD nanoparticles in cells, and addition of strain results in an increase in cytokine production and QD uptake, resulting in irritation and a negative impact on cell viability.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 chapter
Dermatotoxicology
In R. C. Smart & E. Hodgson (Eds.), Molecular and biochemical toxicology (4th ed.) (pp. 851–880).
Ed(s): R. Smart & E. Hodgson
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018
2008 journal article
Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes
JOURNAL OF APPLIED TOXICOLOGY, 28(4), 543–553.
Contributors: A. Inman n, n & J. Riviere n
author keywords: jet fuel; JP-8; skin toxicity; S-8; NF-kappa B; parthenolide; isohelenin; substance P; SB 203580; recombinant human IL-10
MeSH headings : Alkanes / toxicity; Anti-Inflammatory Agents / metabolism; Anti-Inflammatory Agents / pharmacology; Cell Survival / drug effects; Cells, Cultured; Cytokines / metabolism; Humans; Hydrocarbons / toxicity; Imidazoles / pharmacology; Interleukin-10 / metabolism; Irritants / toxicity; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; NF-kappa B / antagonists & inhibitors; NF-kappa B / metabolism; Protein Kinase Inhibitors / pharmacology; Pyridines / pharmacology; Recombinant Proteins / metabolism; Sesquiterpenes / pharmacology; Substance P / metabolism; Time Factors
TL;DR:
This study shows that inhibiting NF‐κB, which appears to play a role in cytokine production in HC‐exposed HEK in vitro, may reduce the inflammatory effect of HC in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Mechanical and biological properties of nanoporous carbon membranes
BIOMEDICAL MATERIALS, 3(3).
Contributors: R. Narayan*, R. Aggarwal*, W. Wei*, C. Jin*, n , R. Crombez*, W. Shen*
MeSH headings : Carbon / administration & dosage; Carbon / chemistry; Cell Survival / drug effects; Cells, Cultured; Elasticity; Hardness; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Materials Testing; Membranes, Artificial; Nanostructures / administration & dosage; Nanostructures / chemistry; Nanostructures / ultrastructure; Particle Size; Porosity; Stress, Mechanical; Tensile Strength
TL;DR:
The structural, mechanical and biological properties of nanoporous alumina membranes coated with diamond-like carbon thin films were examined and it is anticipated that this novel membrane material could find use in immunoisolation devices, kidney dialysis membranes and other medical devices encountering biocompatibility issues that limit in vivo function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Nanoceria as antioxidant: Synthesis and biomedical applications
JOM, 60(3), 33–37.
Contributors: A. Karakoti *, n , R. Aggarwal n, J. Davis n, R. Narayan n, W. Self*, J. McGinnis*, S. Seal *
TL;DR:
The therapeutic application of nanomaterials has been a focus of numerous studies in the past decade, and the radical-scavenging role of ceria nanoparticles (nanoceria) have been established, as well as the autocatalytic ability of nanoceria to regenerate under various environmental conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 chapter
Solvents and vehicle effects on the skin
In M. S. Roberts & K. A. Walters (Eds.), Dermal absorption and toxicity assessment. (2nd ed.) (pp. 433–447). New York: Informa Healthcare.
Ed(s): M. Roberts & K. Walters
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Topical isoflavones provide effective photoprotection to skin
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, 24(2), 61–66.
Contributors: J. Lin*, J. Tournas, J. Burch, * & J. Zielinski
author keywords: antioxidants; isoflavones; photoprotection
MeSH headings : Administration, Cutaneous; Animals; Ascorbic Acid / administration & dosage; Ascorbic Acid / pharmacology; Ascorbic Acid / therapeutic use; Coumaric Acids / administration & dosage; Coumaric Acids / pharmacology; Coumaric Acids / therapeutic use; Dose-Response Relationship, Drug; Drug Combinations; Equol; Genistein / administration & dosage; Genistein / pharmacology; Genistein / therapeutic use; Isoflavones / administration & dosage; Isoflavones / pharmacology; Isoflavones / therapeutic use; Phytotherapy; Plants, Medicinal; Skin / drug effects; Skin / radiation effects; Sunburn / pathology; Sunburn / prevention & control; Sunlight / adverse effects; Sunscreening Agents / administration & dosage; Sunscreening Agents / pharmacology; Sunscreening Agents / therapeutic use; Swine; Vitamin E / administration & dosage; Vitamin E / pharmacology; Vitamin E / therapeutic use
TL;DR:
The aim of this study is to obtain a more comprehensive understanding of the isoflavone‐mediated photoprotection with the pig skin model, a more human‐resembling model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 chapter
Toxicological impacts of nanomaterials
In M. R. Wiesner & J. Y. Bottero (Eds.), Environmental nanotechnology: Applications and impacts of nanomaterials (pp. 395–444). New York: McGraw-Hill.
Ed(s): M. Wiesner & J. Bottero
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
A linear dilution microfluidic device for cytotoxicity assays
LAB ON A CHIP, 7(2), 226–232.
MeSH headings : Cells, Cultured; Combinatorial Chemistry Techniques; Diffusion; Drug Evaluation, Preclinical / instrumentation; Drug Evaluation, Preclinical / methods; Electrochemistry / methods; Equipment Design; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Microchemistry; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods; Microfluidics; Models, Statistical; Models, Theoretical
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
A system coefficient approach for quantitative assessment of the solvent effects on membrane absorption from chemical mixtures
SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 18(5-6), 579–593.
Contributors: X. Xia n, R. Baynes n, n & J. Riviere n
author keywords: membrane absorption; chemical mixtures; solvent effects; system coefficient approach; solute descriptors
MeSH headings : Absorption; Dimethylpolysiloxanes / chemistry; Dimethylpolysiloxanes / metabolism; Kinetics; Membranes, Artificial; Models, Biological; Models, Chemical; Quantitative Structure-Activity Relationship; Regression Analysis; Silicones / chemistry; Silicones / metabolism; Solvents / chemistry
TL;DR:
A system coefficient approach is proposed for quantitative assessment of the solvent effects on membrane absorption from chemical mixtures using Polydimethylsiloxane membrane-coated fibres and 32 probe compounds to demonstrate the proposed approach.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber array
TOXICOLOGY AND APPLIED PHARMACOLOGY, 221(3), 320–328.
Contributors: X. Xia n, R. Baynes n, n & J. Riviere n
author keywords: skin permeability; predictive model; membrane-coated fiber; distribution coefficients; percutaneous absorption
MeSH headings : Algorithms; Complex Mixtures / chemistry; Complex Mixtures / pharmacokinetics; Forecasting; Humans; Membranes, Artificial; Models, Biological; Organic Chemicals / chemistry; Organic Chemicals / pharmacokinetics; Permeability; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / metabolism; Reproducibility of Results; Skin / metabolism; Skin Absorption / drug effects; Structure-Activity Relationship
TL;DR:
The MCF array approach is an experimentally based, high throughput approach that provides high prediction confidence and does not require literature data nor molecular structure information in contrast to the existing predictive models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 chapter
Animal skin morphology and dermal absorption
In Dermal Absorption and Toxicity Assessment, Second Edition (pp. 17–36). http://www.scopus.com/inward/record.url?eid=2-s2.0-77952889776&partnerID=MN8TOARS
Source: ORCID
Added: September 25, 2022
2007 journal article
Biodistribution of quantum dot nanoparticles in perfused skin: Evidence of coating dependency and periodicity in arterial extraction
NANO LETTERS, 7(9), 2865–2870.
Contributors: H. Lee n, M. Imran n, n , V. Colvin n, W. Yu n & J. Rivlere
MeSH headings : Animals; Arteries / chemistry; Coated Materials, Biocompatible / chemistry; Diffusion; Perfusion; Quantum Dots; Skin / blood supply; Skin / chemistry; Skin Absorption / physiology; Swine; Tissue Distribution
TL;DR:
Both QD had a unique periodicity in arterial extraction never observed with drug infusions, suggesting a potentially important nanomaterial behavior that could affect systemic disposition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Biological interactions of functionalized single-wall carbon nanotubes in human epidermal keratinocytes
INTERNATIONAL JOURNAL OF TOXICOLOGY, 26(2), 103–113.
Contributors: L. Zhang n, L. Zeng*, A. Barron * & n
author keywords: cytokines; keratmocytes; nanomaterials; nanotoxicology; single-wall carbon nanotubes; skin
MeSH headings : Aminocaproic Acid / chemistry; Cell Line; Cell Survival / drug effects; Cytokines / metabolism; Cytoplasmic Vesicles / drug effects; Cytoplasmic Vesicles / metabolism; Cytoplasmic Vesicles / ultrastructure; Dose-Response Relationship, Drug; Drug Antagonism; Drug Carriers / chemistry; Drug Carriers / toxicity; Drug Combinations; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Humans; Microscopy, Electron, Transmission; Nanotechnology; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Poloxamer / pharmacology; Surface-Active Agents / pharmacology
TL;DR:
Human epidermal keratinocytes (HEKs) were dosed with 6-Aminohexanoic acid–derivatized single-wall carbon nanotubes and data showed that the lower concentration of 0.000005 mg/ml of AHA-SWNTs maintains cell viability and induces a mild cytotoxicity, but the higher concentration demonstrated an irritation response by the increase in IL-8.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Biological properties of carbon nanotubes
Journal of Nanoscience and Nanotechnology, 7(4-5), 1284–1297.
author keywords: carbon nanotube; biocompatibility; deoxyribonucleic acid; tissue engineering; toxicity
MeSH headings : Animals; Biocompatible Materials / chemistry; Biophysics / methods; Carbon / chemistry; Cell Line; DNA / chemistry; Humans; Microscopy; Microscopy, Electron, Transmission; Nanotechnology / methods; Nanotubes, Carbon / chemistry; Neurons / metabolism; Nucleic Acids / chemistry; Time Factors; Tissue Engineering / methods
TL;DR:
In this review, the processing, chemical properties, physical properties, nucleic acid interaction, cell interaction, and toxicologic properties of nanotubes are described.
(via Semantic Scholar)
Source: ORCID
Added: June 27, 2019
2007 chapter
Dermal effects of nanomaterials
In N. A. Monteiro-Riviere & C. L. Tran (Eds.), Nanotoxicology: Characterization, dosing, and health effects (pp. 317–337). New York: Informa Healthcare.
Ed(s): . N. A. Monteiro-Riviere & C. Tran
Source: NC State University Libraries
Added: August 6, 2018
2007 chapter
Dermal effects of nanomaterials
In Nanotoxicology: Characterization, Dosing and Health Effects (pp. 317–337). http://www.scopus.com/inward/record.url?eid=2-s2.0-41549113687&partnerID=MN8TOARS
Source: ORCID
Added: September 25, 2022
2007 journal article
Dermal exposure to nanomaterials.
Environmental and Molecular Mutagenesis, 48(7), 533. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000248865500032&KeyUID=WOS:000248865500032
Source: ORCID
Added: June 27, 2019
2007 journal article
Development, optimization, and characterization of electrospun poly(lactic acid) nanofibers containing multi-walled carbon nanotubes
JOURNAL OF APPLIED POLYMER SCIENCE, 105(3), 1668–1678.
Contributors: S. McCullen n, K. Stano n, D. Stevens n, W. Roberts n, n , L. Clarke n , R. Gorga n
author keywords: electrospinning; polymers; nanofibers; carbon nanotubes; electrical properties; mechanical properties; electron microscopy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 chapter
Effect of carbon nanotube exposure on keratinocyte protein expression
In N. A. Monteiro-Riviere & C. L. Tran (Eds.), Nanotoxicology: Characterization, Dosing and Health Effects (pp. 197–224). http://www.scopus.com/inward/record.url?eid=2-s2.0-84882791035&partnerID=MN8TOARS
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2007 journal article
Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin
NANO LETTERS, 7(1), 155–160.
Contributors: J. Rouse n, J. Yang n, J. Ryman-Rasmussen n, A. Barron n & n
MeSH headings : Amino Acids / chemistry; Fluorescein-5-isothiocyanate; Fullerenes / chemistry; Microscopy, Confocal; Nanoparticles / chemistry; Nuclear Localization Signals; Peptides / pharmacokinetics; Skin Absorption
TL;DR:
TEM analysis revealed fullerene-peptide localization within the intercellular spaces of the stratum granulosum in skin flexed for 60 and 90 min, whereas Baa-Lys(FITC)-NLS did not penetrate into the dermis of unflexed skin until 24 h.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Meeting report: Hazard assessment for nanoparticles - Report from an interdisciplinary workshop
ENVIRONMENTAL HEALTH PERSPECTIVES, 115(11), 1654–1659.
Contributors: J. Balbus, A. Maynard, V. Colvin, V. Castranova, G. Daston, R. Denison, K. Dreher, P. Goering
author keywords: nanomaterials; nanoparticle; nanotechnology; nanotoxicology; particle toxicology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Meeting report: Hazard assessment for nanoparticles-report from an interdisciplinary workshop
Environmental Health Perspectives, 115(11), 1654–1659.
Contributors: J. Balbus *, A. Maynard *, V. Colvin *, V. Castranova*, G. Daston*, R. Denison*, K. Dreher*, P. Goering *
MeSH headings : Genetic Engineering / methods; Hazardous Substances / analysis; Hazardous Substances / toxicity; Humans; Nanoparticles / analysis; Nanoparticles / toxicity; Nanotechnology / methods; Public Health; Risk Assessment / methods; Toxicology / methods
TL;DR:
Predicting the potential toxicity of emerging nanoparticles will require hypothesis-driven research that elucidates how physicochemical parameters influence toxic effects on biological systems, and a battery of tests should be developed to uncover particularly hazardous properties.
(via Semantic Scholar)
Source: ORCID
Added: September 25, 2022
2007 book
Nanotoxicology: Characterization, dosing and health effects
New York: Informa Healthcare.
Source: NC State University Libraries
Added: August 6, 2018
2007 book
Nanotoxicology: Characterization, dosing and health effects
In Nanotoxicology: Characterization, Dosing and Health Effects (pp. 1–435). http://www.scopus.com/inward/record.url?eid=2-s2.0-84907389735&partnerID=MN8TOARS
Source: ORCID
Added: September 25, 2022
2007 book
Preface
In Nanotoxicology: Characterization, Dosing and Health Effects (pp. iii-iv). http://www.scopus.com/inward/record.url?eid=2-s2.0-85057430652&partnerID=MN8TOARS
Source: ORCID
Added: September 25, 2022
2007 report
Quantitating the absorption, partitioning and toxicity of hydrocarbon components of JP-8 jet fuel
(Center for Chemical Toxicology Research and Pharmacokinetics Grant No. FA9550-04-1-0376).
Source: NC State University Libraries
Added: August 6, 2018
2007 chapter
Solvent and vehicle effects on the skin
In Dermal Absorption and Toxicity Assessment, Second Edition (pp. 433–448). http://www.scopus.com/inward/record.url?eid=2-s2.0-85056948070&partnerID=MN8TOARS
Source: ORCID
Added: September 25, 2022
2007 journal article
Surface coatings determine cytotoxicity and irritation potential of quantum dot nanoparticles in epidermal keratinocytes
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 127(1), 143–153.
Contributors: J. Ryman-Rasmussen n, J. Riviere n & n
MeSH headings : Cells, Cultured; Drug Delivery Systems / adverse effects; Epidermis; Humans; Interleukin-1 / metabolism; Interleukin-10 / metabolism; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Irritants / toxicity; Keratinocytes; Microscopy, Confocal; Microscopy, Electron, Scanning; Nanoparticles / administration & dosage; Nanoparticles / toxicity; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Human epidermal keratinocytes (HEKs) were used to assess if QDs with different surface coatings would cause differential effects on HEK cytotoxicity, proinflammatory cytokine release, and cellular uptake, and data indicate that QD surface coating is a primary determinant of cytot toxicity and immunotoxicity in HEKs, which is consistent across size.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 article
Towards an in vivo biologically inspired nanofactory
LeDuc, P. R., Wong, M. S., Ferreira, P. M., Groff, R. E., Haslinger, K., Koonce, M. P., … Yoda, M. (2007, January). NATURE NANOTECHNOLOGY, Vol. 2, pp. 3–7.
Contributors: P. LeDuc*, M. Wong *, P. Ferreira *, R. Groff *, K. Haslinger*, M. Koonce*, W. Lee*, J. Love*
MeSH headings : Biomimetics / trends; Cell Transplantation / trends; Drug Carriers / chemistry; Nanostructures / chemistry; Nanotechnology / trends
TL;DR:
It may, however, be possible to go even further and design 'pseudo-cell' nanofactories that work with molecules already in the body to fight disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Two photon polymerization of polymer-ceramic hybrid materials for transdermal drug delivery
INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, 4(1), 22–29.
Contributors: A. Ovsianikov *, B. Chichkov *, P. Mente n, n , A. Doraiswamy * & R. Narayan n
TL;DR:
2PP is able to create microneedle structures for transdermal drug delivery with a larger range of geometries than conventional microfabrication techniques, and human epidermal keratinocyte viability on the Ormocer® surfaces polymerized using 2PP was similar to that on control surfaces.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Variables influencing interactions of untargeted quantum dot nanoparticles with skin cells and identification of biochemical modulators
NANO LETTERS, 7(5), 1344–1348.
Contributors: J. Ryman-Rasmussen n, J. Riviere n & n
MeSH headings : Amines / metabolism; Carboxylic Acids / metabolism; Cells, Cultured; Nanoparticles; Polyethylene Glycols / metabolism; Quantum Dots; Skin / cytology; Skin / metabolism
TL;DR:
Biochemical inhibitors were identified that attenuate and potentiate QD-NHEK interactions that are important for understanding and controlling interactions of untargeted QD with cells.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
A physiologically based pharmacokinetic model of organophosphate dermal absorption
TOXICOLOGICAL SCIENCES, 89(1), 188–204.
Contributors: D. Merwe n, J. Brooks n, R. Gehring n, R. Baynes n, n & J. Riviere n
author keywords: dermal absorption; PBPK model; parathion; fenthion; methyl parathion
MeSH headings : Administration, Cutaneous; Animals; Dose-Response Relationship, Drug; Fenthion / pharmacokinetics; In Vitro Techniques; Insecticides / pharmacokinetics; Methyl Parathion / pharmacokinetics; Models, Biological; Organothiophosphorus Compounds / pharmacokinetics; Parathion / pharmacokinetics; Risk Assessment; Skin / metabolism; Skin Absorption / physiology; Skin Physiological Phenomena; Solubility; Swine
TL;DR:
The similarity between the overall shapes of the experimental and model-predicted flux/time curves and the successful simulation of altered system conditions for this series of small, lipophilic compounds indicated that the absorption processes were successfully simulated important aspects of dermal absorption in flow-through cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 conference paper
A serial dilution microfluidic device for cytotoxicity assays
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2836–2839.
MeSH headings : Biological Assay / instrumentation; Biological Assay / methods; Cell Culture Techniques / instrumentation; Cell Culture Techniques / methods; Computer-Aided Design; Equipment Design; Equipment Failure Analysis; Flow Cytometry / instrumentation; Flow Cytometry / methods; Flow Injection Analysis / instrumentation; Flow Injection Analysis / methods; Microfluidic Analytical Techniques / instrumentation; Toxicity Tests / instrumentation; Toxicity Tests / methods
TL;DR:
A novel microfluidic device is presented which creates a linear serial dilution of two input fluid streams which facilitates higher productivity as a component of a high throughput cytotoxicity testing strategy.
(via Semantic Scholar)
Source: ORCID
Added: September 25, 2022
2006 chapter
A serial dilution microfluidic device for cytotoxicity assays
In 28th annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 2836–2839). Piscataway, NJ: IEEE.
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
A serial dilution microfluidic device for cytotoxicity assays
2006 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-15, 3038–3041. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000247284703129&KeyUID=WOS:000247284703129
Source: ORCID
Added: June 27, 2019
2006 journal article
Challenges for assessing carbon nanomaterial toxicity to the skin
CARBON, 44(6), 1070–1078.
Contributors: n & A. Inman n
author keywords: carbon nanoparticles; bioactivity; scanning electron microscopy; transmission electron microscopy; aggregation
TL;DR:
It is suggested that carbon black may not be optimal control particles for assessing nanomaterial toxicity in epidermal cell culture systems due to the wide range of responses seen between the carbon black varieties.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Dermatological effects of chronic exposure to 7,12-dimethylbenz[a]anthracene (DMBA) or N-methyl-N-nitrosoguanidine (MNNG) in swine
CUTANEOUS AND OCULAR TOXICOLOGY, 25(2), 103–119.
Contributors: n , A. Inman n, V. Hedgpeth n, B. Mosteller n & J. Piedrahita n
author keywords: DMBA; MNNG; skin cancer; swine
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Analysis of Variance; Animals; Cocarcinogenesis; Female; Methylnitronitrosoguanidine / toxicity; Neoplasms, Radiation-Induced; Skin / drug effects; Skin / radiation effects; Skin Neoplasms / chemically induced; Swine; Ultraviolet Rays
TL;DR:
The findings show that although chronic exposure to MNNG and DMBA, with or without UVB exposure, caused severe to mild dermatopathological changes, neither resulted in the development of skin carcinomas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Dermatotoxicity of cutting fluid mixtures: In vitro and in vivo studies
CUTANEOUS AND OCULAR TOXICOLOGY, 25(4), 235–247.
author keywords: alkylbenzene sulfonate; cutting fluids; HEK; mixtures; ricinoleic acid; triazine; triethanolamine
MeSH headings : Animals; Cell Survival / drug effects; Cells, Cultured; Dermatitis, Contact / etiology; Dermatitis, Contact / metabolism; Dermatitis, Contact / pathology; Dermatitis, Occupational / etiology; Dermatitis, Occupational / metabolism; Dermatitis, Occupational / pathology; Dose-Response Relationship, Drug; Female; Humans; Interleukin-8 / metabolism; Kidney / cytology; Kidney / drug effects; Kidney / embryology; Metallurgy; Mineral Oil / pharmacokinetics; Mineral Oil / toxicity; Occupational Exposure; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Absorption; Swine
TL;DR:
Preliminary studies suggest that the biocide, TRI, is the more potent of the 4 performance additives in causing dermal irritation, and this may vary depending on whether the worker is exposed to a synthetic (PEG)- or MO-based fluid.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Expression profiling of human epidermal keratinocyte response following 1-minute JP-8 exposure
CUTANEOUS AND OCULAR TOXICOLOGY, 25(2), 141–153.
Contributors: C. Chou*, J. Yang*, S. Chen*, n , H. Li* & J. Chen*
author keywords: cDNA microarray; gene expression; jet fuel; keratinocyte
MeSH headings : Adult; Apoptosis; Cell Adhesion; Colorimetry; DNA Repair; Down-Regulation; Gene Expression Profiling; Humans; Hydrocarbons / pharmacology; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Nucleic Acid Hybridization; Signal Transduction; Skin / drug effects; Skin / metabolism
TL;DR:
Results indicated that human keratinocyte responds to a single dose of JP-8 insult and revealed several cellular processes previously not associated with jet fuel exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Fullerene-based amino acid nanoparticle interactions with human epidermal keratinocytes
TOXICOLOGY IN VITRO, 20(8), 1313–1320.
Contributors: J. Rouse n, J. Yang *, A. Barron * & n
author keywords: fullerene; cytotoxicity; human epidermal keratinocytes; nanoparticles
MeSH headings : Amino Acids / toxicity; Cell Line; Cell Survival / drug effects; Cytokines / analysis; Cytokines / biosynthesis; Cytokines / metabolism; Dose-Response Relationship, Drug; Epidermal Cells; Epidermis / drug effects; Fullerenes / toxicity; Humans; Keratinocytes / drug effects; Microscopy, Electron, Transmission; Nanoparticles / toxicity; Tetrazolium Salts; Thiazoles; Vacuoles / drug effects; Vacuoles / ultrastructure
TL;DR:
Results indicate that concentrations lower than 0.04 mg/mL initiate less cytokine activity and maintain cell viability in HEK, and decrease cell viability and initiate a pro-inflammatory response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Multi-walled carbon nanotube exposure alters protein expression in human keratinocytes
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2(3), 158–168.
MeSH headings : Cells, Cultured; Cytokines / metabolism; Environmental Exposure / adverse effects; Gene Expression / drug effects; Gene Expression / physiology; Gene Expression Profiling; Humans; Keratinocytes / drug effects; Keratinocytes / physiology; Nanotubes, Carbon / toxicity
TL;DR:
Data show that MWCNTs are capable of altering protein expression in a target epithelial cell that constitutes a primary route of occupational exposure for manufactured nanotubes, and this effect on the expression of cytoskeletal elements and vesicular trafficking components is consistent.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2006 journal article
Nanomaterials and the skin
Nanomedicine-Nanotechnology Biology and Medicine, 2(4), 303.
Source: ORCID
Added: June 27, 2019
2006 article
New technology and clinical applications of nanomedicine: Highlights of the second annual meeting of the American Academy of Nanomedicine (part I)
Wei, C., Lyubchenko, Y. L., Ghandehari, H., Hanes, J., Stebe, K. J., Mao, H.-Q., … Needham, D. (2006, December). NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Vol. 2, pp. 253–263.
Contributors: C. Wei *, Y. Lyubchenko *, H. Ghandehari*, J. Hanes *, K. Stebe *, H. Mao *, D. Haynie*, D. Tomalia *
MeSH headings : Academies and Institutes; Animals; Biosensing Techniques; Dendrimers / chemistry; Drug Delivery Systems; Gene Transfer Techniques; Humans; Mice; Nanomedicine / methods; Nanomedicine / trends; Nanostructures / therapeutic use; Nanotechnology / methods; Nanotechnology / trends; United States
TL;DR:
The second annual meeting of the AANM provided investigators from different world areas a forum and an opportunity for discussion and it is believed that nanomedicine research will develop rapidly in the future.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2006 journal article
Penetration of intact skin by quantum dots with diverse physicochemical properties
TOXICOLOGICAL SCIENCES, 91(1), 159–165.
Contributors: J. Ryman-Rasmussen n, J. Riviere n & n
author keywords: quantum dots; semiconductor nanocrystals; skin; nanomaterials; nanotoxicology
MeSH headings : Animals; Female; Microscopy, Confocal; Quantum Theory; Skin Absorption; Spectrometry, Fluorescence; Swine
TL;DR:
It is shown that quantum dots of different sizes, shapes, and surface coatings can penetrate intact skin at an occupationally relevant dose within the span of an average-length work day, suggesting that skin is surprisingly permeable to nanomaterials with diverse physicochemical properties.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Skin penetration, cytotoxicity, proteomic analyses, and inflammatory potential of nanomaterials; fullerenes, multi-walled carbon nanotubes and quantum dots
Journal of Veterinary Pharmacology and Therapeutics, 29(Sup. 1), 196–197.
Source: NC State University Libraries
Added: August 6, 2018
2006 chapter
Structure and function of skin
In Dermal absorption models in toxicology and pharmacology (pp. 1–19). Boca Raton: Taylor & Francis.
Source: NC State University Libraries
Added: August 6, 2018
2006 chapter
The integument
In J. A. Eurell & B. L. Frappier (Eds.), Dellmann's textbook of veterinary histology (pp. 320–349). Ames, IA: Blackwell Publishing.
Ed(s): . J. A. Eurell & B. Frappier
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release
ARCHIVES OF TOXICOLOGY, 80(8), 508–523.
Contributors: J. Yang*, C. Lee*, n , J. Riviere n, C. Tsang* & C. Chou *
author keywords: hydrocarbon mixtures; jet fuels; keratinocyte; cytotoxicity; interleukin-8
MeSH headings : Aviation; Cell Survival / drug effects; Cells, Cultured; Complex Mixtures / chemistry; Complex Mixtures / toxicity; Fuel Oils / analysis; Fuel Oils / toxicity; Humans; Hydrocarbons, Aromatic / chemistry; Hydrocarbons, Aromatic / toxicity; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Structure-Activity Relationship
TL;DR:
The results indicated that when hydrocarbons were mixed, HEK mortality and IL-8 release were not all predictable by their individual ability affecting these two parameters, and the mixture effects must be considered when evaluating jet fuel toxicity to HEK.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 chapter
Toxicology of Nanomaterials
In Biological Concepts and Techniques in Toxicology: An Integrated Approach (pp. 217–233). http://www.scopus.com/inward/record.url?eid=2-s2.0-33845739533&partnerID=MN8TOARS
Contributors: & J. Ryman-Rasmussen
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2006 journal article
Trace analysis of fullerenes in biological samples by simplified liquid-liquid extraction and high-performance liquid chromatography
JOURNAL OF CHROMATOGRAPHY A, 1129(2), 216–222.
Contributors: X. Xia n, n & J. Riviere n
author keywords: fullerenes; nanoparticles; colloidal nanoparticles; emulsion; liquid-liquid extraction; solvent evaporation; dermal absorption
MeSH headings : Chromatography, High Pressure Liquid / methods; Emulsions / chemistry; Fullerenes / analysis; Fullerenes / chemistry; Nanoparticles / chemistry; Reproducibility of Results; Solvents / chemistry
TL;DR:
A simplified LLE method was developed for high throughput while preserved the advantages of the traditional LLE and was used for trace analysis of fullerenes in protein containing media and tape-stripped skin samples.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 personal communication
Ubiquinone, idebenone, and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acid
Tournas, J. A., Lin, F.-H., Burch, J. A., Selim, M. A., Monteiro-Riviere, N. A., Zielinski, J. E., & Pinnell, S. R. (2006, May).
MeSH headings : Antioxidants / administration & dosage; Ascorbic Acid / administration & dosage; Benzoquinones / pharmacology; Coumaric Acids / pharmacology; Humans; Kinetin / pharmacology; Radiation-Protective Agents / pharmacology; Skin / drug effects; Skin / radiation effects; Ubiquinone / pharmacology; Ultraviolet Rays; Vitamin E / administration & dosage
TL;DR:
The antioxidant potential of ubiquinone, idebenone, and kinetin were evaluated by measuring their photoprotective value by measuring the a* values of the experimental spots and compiling the statistics and graph the results.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
A topical antioxidant solution containing 15% 1-ascorbic acid, 1% alpha-tocopherol and 0.5% ferulic acid provides superior photoprotection to skin compared to 1% idebenone or 1% ubiquinone
Journal of Investigative Dermatology, 124(4), A136. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000228179901354&KeyUID=WOS:000228179901354
Source: ORCID
Added: June 27, 2019
2005 conference paper
A topical antioxidant solution containing 15% L-ascorbic acid, 1%a-tocopherol and 0.5% ferulic acid (C+E+Ferulic) provides superiorphotoprotection to skin compared to 1% idebenone or 1% ubiquinone
Journal of the European Academy of Dermatology & Venereology, 19(Supplement 2), 47,
Event: 14th Congress of the European Academy of Dermatology and Venereology at London, UK on October 12-15, 2005
Source: NC State University Libraries
Added: June 12, 2021
2005 chapter
An in vivo nanofactory: The medicine of the future
In Designing nanostructures at the interface between biomedical and physical systems (pp. 53–60). Washington, DC: National Academies Press.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Comparative in vivo toxicity of topical JP-8 jet fuel and its individual hydrocarbon components: Identification of tridecane and tetradecane as key constituents responsible for dermal irritation
TOXICOLOGIC PATHOLOGY, 33(2), 258–266.
Contributors: F. Muhammad n, n & J. Riviere n
author keywords: hydrocarbons; skin; in vivo irritation; jet fuel; ultrastructure; pathology
MeSH headings : Administration, Topical; Alkanes / toxicity; Animals; Epidermis / drug effects; Epidermis / ultrastructure; Erythema / chemically induced; Erythema / pathology; Hydrocarbons / chemistry; Hydrocarbons / toxicity; Irritants / chemistry; Irritants / toxicity; Kerosene / toxicity; Swine
TL;DR:
Ulastructural studies depicted that jet fuel HC-induced cleft formation within intercellular lipid lamellar bilayers of the stratum corneum was proportional to the length of in vivo HC exposures and revealed that specific HCs (tridecane and tetradecane) might be the key constituents responsible for jet fuel-induced skin irritation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Determination of the partition coefficients and absorption kinetic parameters of chemicals in a lipophilic membrane/water system by using a membrane-coated fiber technique
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 24(1), 15–23.
Contributors: X. Xia n, R. Baynes n, n & J. Riviere n
author keywords: absorption kinetics; membrane-coated fiber; diffusion coefficient; partition coefficient; boundary layer
MeSH headings : Absorption / drug effects; Absorption / physiology; Kinetics; Lipid Metabolism; Membranes, Artificial; Organic Chemicals / pharmacokinetics; Water / metabolism
TL;DR:
The kinetic model adequately described the absorption kinetics of the MCF technique and suggested that the absorption rate of a very lipophilic compound could be controlled by the boundary layer even though the diffusivity of the compound in the membrane is lower than that in the solution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Effect of JP-8 jet fuel exposure on protein expression in human keratinocyte cells in culture
TOXICOLOGY LETTERS, 160(1), 8–21.
Contributors: F. Witzmann*, n , A. Inman n, M. Kimpel*, N. Pedrick*, H. Ringham*, J. Riviere n
author keywords: jet fuel; keratinocyte; mass spectrometry; proteomics; toxicity; two-dimensional electrophoresis
MeSH headings : Cells, Cultured; Electrophoresis, Gel, Two-Dimensional; Humans; Hydrocarbons / pharmacology; Hydrocarbons / toxicity; Image Processing, Computer-Assisted; Interleukin-8 / biosynthesis; Keratinocytes / drug effects; Keratinocytes / metabolism; Occupational Exposure; Peptide Mapping; Protein Biosynthesis / drug effects; Proteome / biosynthesis; Proteome / drug effects; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
TL;DR:
To examine the effect of JP-8 administration on the human epidermal keratinocyte (HEK) proteome, a two-dimensional electrophoretic approach combined with mass spectrometric-based protein identification and Peptide mass fingerprint identification of effected proteins revealed a variety of functional implications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Effect of in vivo jet fuel exposure on subsequent in vitro dermal absorption of individual aromatic and aliphatic hydrocarbon fuel constituents
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 68(9), 719–737.
Contributors: F. Muhammad n, n , R. Baynes n & J. Riviere n
MeSH headings : Animals; Female; Hydrocarbons / pharmacokinetics; Hydrocarbons / pharmacology; Permeability / drug effects; Skin Absorption / drug effects; Swine
TL;DR:
It is suggested that the preexposure of skin to jet fuel enhances the subsequent in vitro percutaneous absorption of HC, so single-dose absorption data for jet fuel HC from naive skin may not be optimal to predict the toxic potential for repeated exposures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 article
Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin
Lin, F. H., Lin, J. Y., Gupta, R. D., Tournas, J. A., Burch, J. A., Selim, M. A., … al. (2005, October). JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 125, pp. 826–832.
Contributors: F. Lin*, J. Lin*, R. Gupta*, J. Tournas*, J. Burch*, M. Selim*, n , J. Grichnik *, J. Zielinski, . Pinnell*
author keywords: antioxidant; ferulic acid; photoprotection; vitamin C; vitamin E
MeSH headings : Animals; Ascorbic Acid / chemistry; Ascorbic Acid / pharmacology; Coumaric Acids / pharmacology; Drug Stability; Radiation-Protective Agents / pharmacology; Skin Aging / drug effects; Swine; Ultraviolet Rays; Vitamin E / chemistry; Vitamin E / pharmacology
TL;DR:
This combination of pure natural low molecular weight antioxidants provides meaningful synergistic protection against oxidative stress in skin and should be useful for protection against photoaging and skin cancer.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 conference paper
Ferulic acid, a potent plant antioxidant, stabilizes an antioxidant solution containing vitamins C+ E and increases skin photoprotection to eightfold
Photodermatology, Photoimmunology & Photomedicine, 21(3), 170.
Event: 14th Annual Meeting of the Photomedicine Society at New Orleans, Louisiana on February 17, 2005
Source: NC State University Libraries
Added: June 12, 2021
2005 journal article
Kinetin (N6-furfuryladenine) provides only mild photoprotection when compared to a topical antioxidant formulation containing 15% L-ascorbic acid, 1% alpha-tocopherol and 0.5% ferulic acid
Journal of Investigative Dermatology, 124(4), A136. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000228179901353&KeyUID=WOS:000228179901353
Source: ORCID
Added: June 27, 2019
2005 conference paper
Kinetin (N6-furfuryladenine) provides only mild photoprotection whencompared to a topical antioxidant formulation containing 15%L-ascorbic acid, 1% a-tocopherol and 0.5% ferulic acid (C+E+Ferulic)
Journal of the European Academy of Dermatology & Venereology, 19(Supplement 2), 48.
Event: 14th Congress of the European Academy of Dermatology and Venereology at London, UK on October 12-15, 2005
Source: NC State University Libraries
Added: June 12, 2021
2005 journal article
Membrane uptake kinetics of jet fuel aromatic hydrocarbons from aqueous solutions studied by a membrane-coated fiber technique
TOXICOLOGY MECHANISMS AND METHODS, 15(4), 307–316.
Contributors: X. Xia n, R. Baynes n, n & J. Riviere n
author keywords: uptake kinetics; membrane-coated fiber; partition coefficient; jet fuel; aromatic hydrocarbons
TL;DR:
The results suggest that the MCF technique can detect subtle differences in molecular interactions of the two group derivatives between the two membrane/water systems and may be used to study the absorption and permeation properties of closely related compounds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Multi-walled carbon nanotube exposure in human epidermal keratinocytes: Localization and proteomic analysis.
Abstracts of Papers of the American Chemical Society, 229, U911–U912. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000228177706461&KeyUID=WOS:000228177706461
Source: ORCID
Added: June 27, 2019
2005 journal article
Multi-walled carbon nanotube interactions with human epidermal keratinocytes
TOXICOLOGY LETTERS, 155(3), 377–384.
Contributors: n , R. Nemanich n, A. Inman n, Y. Wang n & J. Riviere n
author keywords: multi-wall carbon nanotubes; human epidermal keratinocytes; transmission electron microscopy; IL-8
MeSH headings : Cell Nucleus / ultrastructure; Cell Survival; Cells, Cultured; Cytoplasm / ultrastructure; Humans; Interleukin-8 / biosynthesis; Keratinocytes / drug effects; Keratinocytes / immunology; Keratinocytes / ultrastructure; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanotubes, Carbon / analysis; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / ultrastructure
TL;DR:
Data clearly show that MWCNT, not derivatized nor optimized for biological applications, are capable of both localizing within and initiating an irritation response in a target epithelial cell that composes a primary route of occupational exposure for manufactured nanotubes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Principles for characterizing the potential human health effects from exposure to nanomaterials: Elements of a screening strategy
Particle and Fibre Toxicology, 2(8), 1–35.
Contributors: G. Oberdörster*, A. Maynard *, K. Donaldson *, V. Castranova*, J. Fitzpatrick*, K. Ausman*, J. Carter *, B. Karn*
TL;DR:
The working group report presents a broad data gathering strategy applicable to this early stage in the development of a risk assessment process for nanomaterials, and there is a strong likelihood that biological activity of nanoparticles will depend on physicochemical parameters not routinely considered in toxicity screening studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2005 article
Research strategies for safety evaluation of nanomaterials, part II: Toxicological and safety evaluation of nanomaterials, current challenges and data needs
Holsapple, M. P., Farland, W. H., Landry, T. D., Monteiro-Riviere, N. A., Carter, J. M., Walker, N. J., & Thomas, K. V. (2005, November). TOXICOLOGICAL SCIENCES, Vol. 88, pp. 12–17.
Contributors: M. Holsapple n, W. Farland, T. Landry, * , J. Carter *, N. Walker, K. Thomas
author keywords: nanomaterials; nanoscale materials; nanotechnology; risk assessment; toxicology
MeSH headings : Animals; Environmental Exposure / adverse effects; Environmental Exposure / legislation & jurisprudence; Hazardous Substances / classification; Hazardous Substances / toxicity; Humans; Nanostructures / chemistry; Nanostructures / classification; Nanostructures / toxicity; Nanotechnology; Risk Assessment / methods; Toxicity Tests / methods
TL;DR:
The unique physicochemical properties associated with nanomaterials are reviewed in the context of the difficulties associated with measuring and characterizing them and are discussed as factors that will impact the development of comprehensive toxicological and safety evaluations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Surfactant effects on carbon nanotube interactions with human keratinocytes
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 1(4), 293–299.
Contributors: n , A. Inman n, Y. Wang* & R. Nemanich n
author keywords: Surfactant; Multiwalled carbon nanotubes; Human epidermal keratinocytes
MeSH headings : Apoptosis / drug effects; Cell Survival / drug effects; Cells, Cultured; Colloids / administration & dosage; Colloids / chemistry; Dose-Response Relationship, Drug; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / physiology; Nanotubes, Carbon / adverse effects; Nanotubes, Carbon / chemistry; Surface-Active Agents / administration & dosage; Surface-Active Agents / chemistry
TL;DR:
The results suggest that the surfactant-MWCNT interaction is more complex than simple dispersion alone and should be investigated to determine the mode of interaction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2005 chapter
The pig as a model for human skin research
In M. Swindle & G. F. Bouchard (Eds.), Swine in biomedical research: Update on animal models (pp. 17–22). Sinclair Research Center.
Ed(s): M. Swindle & G. Bouchard
Source: NC State University Libraries
Added: August 6, 2018
2005 conference paper
The pig as a model for human skin research
Swine in Biomedical Research: Update on Animal Models. Sinclair Research Center. 56th AALAS National Meeting, 56, 17–22.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Toll-like receptor gene expression in purified porcine skin dendritic cells
Journal of Investigative Dermatology, 124(4), A122. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000228179901270&KeyUID=WOS:000228179901270
Source: ORCID
Added: June 27, 2019
2004 journal article
A Compartment Model for the Membrane-Coated Fiber Technique Used for Determining the Absorption Parameters of Chemicals into Lipophilic Membranes
Pharmaceutical Research, 21(8), 1345–1352.
Contributors: X. Xia n, R. Baynes n, n & J. Riviere n
author keywords: absorption kinetics; lipophilic membrane; membrane-coated fiber; partition coefficient; uptake rate constant
MeSH headings : Absorption; Gas Chromatography-Mass Spectrometry / methods; Kinetics; Membranes, Artificial; Models, Biological; Permeability; Pesticides / analysis; Pesticides / chemistry; Reproducibility of Results; Solubility
TL;DR:
A compartment model for the membrane-coated fiber (MCF) technique for determining the absorption parameters of chemicals into lipophilic membranes can describe the absorption kinetics of the MCF technique and is a useful tool for the determination of the partition coefficients of Lipophilic compounds when it takes too long for them to reach permeation equilibrium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2004 journal article
A topical antioxidant solution containing vitamin C, vitamin E, and ferulic acid prevents ultraviolet radiation-induced caspase-3 induction in skin
Journal of Investigative Dermatology, 122(3), A148. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000220660500931&KeyUID=WOS:000220660500931
Source: ORCID
Added: June 27, 2019
2004 chapter
Anatomical factors affecting barrier function
In H. Zhai & H. I. Maibach (Eds.), Dematoxicology. (6th ed.) (pp. 42–70). Washington, DC: CRC Press.
Ed(s): H. Zhai & H. Maibach
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Characterization of polyacrylate membrane-coated fibers used in chemical absorption studies with programmed thermal treatment and FT-IR microscopy
ANALYTICAL CHEMISTRY, 76(14), 4245–4250.
Contributors: X. Xia n, R. Baynes n, n & J. Riviere n
TL;DR:
The anhydride formation explained the absorption property of PA MCFs in GC applications where they must be preconditioned at 300 degrees C and suggested that a PA fiber does not preferably absorb polar compounds (with permanent dipole moment); instead, it absorbs preferably aromatic compounds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Dose related absorption of JP-8 jet fuel hydrocarbons through porcine skin with quantitative structure permeability relationship analysis
TOXICOLOGY MECHANISMS AND METHODS, 14(3), 159–166.
Contributors: F. Muhammad n, R. Baynes n, n , X. Xia n & J. Riviere n
author keywords: absorption; GC-SPME; hydrocarbons; jet fuels; porcine skin; QSPR
TL;DR:
The findings suggested a dose related increase in absorption for naphthalene and dimethyl naphthaene (DMN) in this solvent system by using their physicochemical parameters.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Ferulic acid stabilizes a topical solution containing vitamins C & E and doubles its photoprotection for skin
Ferulic acid stabilizes a topical solution containing vitamins C & E and doubles its photoprotection for skin. Journal of Investigative Dermatology, 122(3), A148. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000220660500934&KeyUID=WOS:000220660500934
Source: ORCID
Added: June 27, 2019
2004 journal article
Pathogenesis of acute ulceration response (AUR) in hybrid striped bass
DISEASES OF AQUATIC ORGANISMS, 61(3), 199–213.
Contributors: P. Udomkusonsri n, E. Noga n & n
author keywords: skin ulceration; striped bass; acute stress; pathology
MeSH headings : Analysis of Variance; Animals; Bass; Crowding / physiopathology; Epidermis / ultrastructure; Fish Diseases / etiology; Fish Diseases / pathology; Histological Techniques; Microscopy, Electron, Transmission; Skin Ulcer / etiology; Skin Ulcer / pathology; Skin Ulcer / veterinary; Stress, Physiological / pathology; Stress, Physiological / veterinary; Time Factors
TL;DR:
The response to acute stress showed a significant correlation between confinement period and severity of the pathological changes (epidermal degeneration, epidermal ulceration and leukocyte infiltration), and it was demonstrated that epidersmal damage was not restricted to the fins but also affected the body skin and eyes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Skin toxicity of jet fuels: ultrastructural studies and the effects of substance P
TOXICOLOGY AND APPLIED PHARMACOLOGY, 195(3), 339–347.
Contributors: n , A. Inman n & J. Riviere n
author keywords: skin; Jet A; JP-8; JP-8+100; substance P; jet fuels
MeSH headings : Administration, Cutaneous; Animals; Cell Line; Humans; Hydrocarbons / toxicity; Interleukin-8 / immunology; Keratinocytes / drug effects; Keratinocytes / immunology; Keratinocytes / ultrastructure; Kerosene / toxicity; Microscopy, Electron; Mitochondrial Swelling / drug effects; Mitochondrial Swelling / immunology; Skin / drug effects; Skin / immunology; Skin / ultrastructure; Substance P / immunology; Substance P / pharmacology; Swine
TL;DR:
The primary change seen after exposure to all fuels was low-level inflammation accompanied by formation of lipid droplets in various skin layers, mitochondrial and nucleolar changes, cleft formation in the intercellular lipid lamellar bilayers, as well as disorganization in the stratum granulosum-stratum corneum interface.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 personal communication
alpha-Lipoic acid is ineffective as a topical antioxidant for photoprotection of skin
Lin, J. Y., Lin, F. H., Burch, J. A., Selim, M. A., Monteiro-Riviere, N. A., Grichnik, J. M., & Pinnell, SR. (2004, November).
Contributors: J. Lin*, F. Lin*, J. Burch*, M. Selim*, n , J. Grichnik *, . Pinnell*
MeSH headings : Administration, Topical; Animals; Antioxidants / pharmacology; Skin / drug effects; Skin / radiation effects; Thioctic Acid / pharmacology; Ultraviolet Rays / adverse effects
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
A mathematical model of the permeation kinetics of the membrane-coated fiber technique accounting for partition, diffusion and boundary layer factors.
Toxicological Sciences, 72, 379. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000181518501848&KeyUID=WOS:000181518501848
Source: ORCID
Added: June 27, 2019
2003 journal article
A novel in-vitro technique for studying percutaneous permeation with a membrane-coated fiber and gas chromatography/mass spectrometry: Part I. Performances of the technique and determination of the permeation rates and partition coefficients of chemical mixtures
PHARMACEUTICAL RESEARCH, 20(2), 275–282.
Contributors: X. Xia n, R. Baynes n, n , R. Leidy n, D. Shea n & J. Riviere n
author keywords: in-vitro; percutaneous absorption; membrane-coated fiber; chemical mixtures; partition coefficient
MeSH headings : Administration, Cutaneous; Gas Chromatography-Mass Spectrometry / instrumentation; Gas Chromatography-Mass Spectrometry / methods; Membranes, Artificial; Permeability; Pharmaceutical Preparations / analysis; Pharmaceutical Preparations / metabolism
TL;DR:
A novel in-vitro technique for rapid assessment of percutaneous absorption of chemical mixtures and the initial permeation rate and equilibrium time can be obtained for each compound, which could serve as characteristic parameters regarding the skin permeability of the compound.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Absorption through porcine skin exposed to various doses of jet fuel marker components determined with GC-FID using head space SPME fiber.
Toxicological Sciences, 72, 383. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000181518501865&KeyUID=WOS:000181518501865
Source: ORCID
Added: June 27, 2019
2003 journal article
Cutaneous toxicity current methods and concepts in safety evaluation and relevance to human exposure.
Toxicological Sciences, 72, 1–2. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000181518500007&KeyUID=WOS:000181518500007
Source: ORCID
Added: June 27, 2019
2003 journal article
Dose-related interleukin-8 release from epidermal keratinocytes after exposure to jet fuel aromatic hydrocarbons.
Journal of Veterinary Pharmacology and Therapeutics, 26(Supplement 1), 162. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BIOSIS&KeyUT=BIOSIS:PREV200300446377&KeyUID=BIOSIS:PREV200300446377
Source: ORCID
Added: June 27, 2019
2003 journal article
In vitro percutaneous absorption of nonylphenol (NP) and nonylphenol ethoxylates (NPE-4 and NPE-9) in isolated perfused skin
JOURNAL OF TOXICOLOGY-CUTANEOUS AND OCULAR TOXICOLOGY, 22(1-2), 1–11.
Contributors: n , J. Van Miller, G. Simon, R. Joiner*, J. Brooks n & J. Riviere n
TL;DR:
The penetration of NPEs and NP in the IPPSF was less than the PSFT and is probably more predictive of in vivo human absorption as this model is physiologically closer to human skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Percutaneous Absorption of Topical N , N -Diethyl- m -Toluamide (Deet): Effects of Exposure Variables and Coadministered Toxicants
Journal of Toxicology and Environmental Health, Part A, 66(2), 133–151.
Contributors: J. Riviere n, R. Baynes n, J. Brooks n, J. Yeatts n & n
MeSH headings : Administration, Cutaneous; Animals; Chemical Warfare Agents / adverse effects; Chemical Warfare Agents / pharmacokinetics; Chromatography, High Pressure Liquid; DEET / administration & dosage; DEET / adverse effects; DEET / pharmacokinetics; Drug Interactions; Insect Repellents / administration & dosage; Insect Repellents / adverse effects; Insect Repellents / pharmacokinetics; Isoflurophate / administration & dosage; Isoflurophate / adverse effects; Isoflurophate / pharmacokinetics; Middle East; Military Personnel; Mustard Gas / administration & dosage; Mustard Gas / adverse effects; Mustard Gas / pharmacokinetics; Occupational Exposure; Pyridostigmine Bromide / administration & dosage; Pyridostigmine Bromide / adverse effects; Pyridostigmine Bromide / pharmacokinetics; Skin Absorption; Swine; Warfare
TL;DR:
The results suggest that coexposure to a number of chemicals that potentially could be encountered in a military environment may modulate the percutaneous absorption of topically applied DEET beyond that seen for normal vehicles at typically applied concentrations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: ORCID, Crossref
Added: June 27, 2019
2003 journal article
Percutaneous absorption of 2,6-di-tert-butyl-4-nitrophenol (DBNP) in isolated per-fused porcine skin.
Toxicological Sciences, 72, 383. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000181518501864&KeyUID=WOS:000181518501864
Source: ORCID
Added: June 27, 2019
2003 journal article
Percutaneous absorption of 2,6-di-tert-butyl-4-nitrophenol (DBNP) in isolated perfused porcine skin
TOXICOLOGY IN VITRO, 17(3), 289–292.
Contributors: A. Inman n, K. Still*, W. Jederberg*, R. Carpenter*, J. Riviere n, J. Brooks n, n
author keywords: 2,6-di-tert-butyl-4-nitrophenol; skin absorption; porcine skin; dermal exposure
MeSH headings : Absorption; Administration, Cutaneous; Air Pollution, Indoor; Animals; Antioxidants; Humans; Military Personnel; Nitrophenols / pharmacokinetics; Phenols / chemistry; Skin Physiological Phenomena; Static Electricity; Submarine Medicine; Swine
TL;DR:
DBNP absorption was minimal across all treatment groups, with the highest absorption detected being only 1.08% applied dose in an aqueous ethanol group, suggesting that there is minimal dermal exposure of DBNP when exposed topically to skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Percutaneous absorption of topical N,N-diethyl-m-toluamide (DEET): Effects of exposure variables and coadministered toxicants
Journal of Toxicology and Environmental Health. Part A, 66(2), 133–151.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2003 journal article
Pyridostigmine bromide modulates topical irritant-induced cytokine release from human epidermal keratinocytes and isolated perfused porcine skin
TOXICOLOGY, 183(1-3), 15–28.
Contributors: n , R. Baynes n & J. Riviere n
author keywords: pyridostigmine bromide; skin; cytokines; permethrin; DEET; diisopropylfluorophosphate
MeSH headings : Administration, Cutaneous; Animals; Cells, Cultured; Cholinesterase Inhibitors / pharmacokinetics; Cholinesterase Inhibitors / toxicity; Cytokines / biosynthesis; Cytokines / metabolism; DEET / administration & dosage; DEET / pharmacokinetics; DEET / toxicity; Dinoprostone / biosynthesis; Drug Interactions; Female; Humans; In Vitro Techniques; Insect Repellents / administration & dosage; Insect Repellents / pharmacokinetics; Insect Repellents / toxicity; Insecticides / administration & dosage; Insecticides / pharmacokinetics; Insecticides / toxicity; Interleukin-8 / biosynthesis; Keratinocytes / drug effects; Keratinocytes / metabolism; Permethrin / administration & dosage; Permethrin / pharmacokinetics; Permethrin / toxicity; Persian Gulf Syndrome / chemically induced; Pyridostigmine Bromide / pharmacokinetics; Pyridostigmine Bromide / toxicity; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Skin Absorption / physiology; Swine; Tumor Necrosis Factor-alpha / biosynthesis
TL;DR:
It is suggested that systemic exposure to PB suppressed IL-8 release at multiple time points in two skin model systems, and effects on TNF-alpha and PGE(2) were vehicle dependent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
The cytotoxicity of jet fuel aromatic hydrocarbons and dose-related interleukin-8 release from human epidermal keratinocytes
Archives of Toxicology, 77(7), 384–391.
Contributors: C. Chou n, J. Riviere n & n
author keywords: aromatic hydrocarbons; cytotoxicity; keratinocytes; interleukin-8; jet fuels
MeSH headings : Aircraft; Cells, Cultured; Epidermal Cells; Fuel Oils / toxicity; Humans; Hydrocarbons, Aromatic / toxicity; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Time Factors
TL;DR:
The presence of hexadecane and mineral oil greatly attenuated the cytotoxicity elicited by individual aromatic hydrocarbons in HEK cells and significantly increased with both doses of methylnaphthalene and naphthalenes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref, NC State University Libraries
Added: August 6, 2018
2003 article
UV photoprotection by combination topical antioxidants vitamin C and vitamin E
Lin, J. Y., Selim, M. A., Shea, C. R., Grichnik, J. M., Omar, M. M., Monteiro-Riviere, N. A., & Pinnell, SR. (2003, June). JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 48, pp. 866–874.
Contributors: J. Lin*, M. Selim*, C. Shea*, J. Grichnik *, M. Omar, n , . Pinnell*
MeSH headings : Animals; Antioxidants / administration & dosage; Antioxidants / therapeutic use; Ascorbic Acid / administration & dosage; Ascorbic Acid / therapeutic use; Drug Combinations; Erythema / prevention & control; Immunohistochemistry; Pyrimidine Dimers / biosynthesis; Sunburn / prevention & control; Swine; Vitamin E / administration & dosage; Vitamin E / therapeutic use
TL;DR:
Appreciable photoprotection can be obtained from the combination of topical vitamins C and E and it is suggested that these natural products may protect against skin cancer and photoaging.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2002 journal article
Differential relationship between the carbon chain length of jet fuel aliphatic hydrocarbons and their ability to induce cytotoxicity vs. interleukin-8 release in human epidermal keratinocytes
TOXICOLOGICAL SCIENCES, 69(1), 226–233.
Contributors: C. Chou n, J. Riviere* & *
author keywords: keratinocytes; aliphatic hydrocarbons; cytotoxicity; interleukin-8; jet fuels
MeSH headings : Aviation; Cell Survival / drug effects; Cells, Cultured; Epidermal Cells; Fuel Oils / toxicity; Humans; Hydrocarbons / toxicity; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Structure-Activity Relationship
TL;DR:
Individual aliphatic hydrocarbons are toxic to HEK cells and are capable of inducing proinflammatory cytokines, indicating a different structure-activity relationship for these two toxicological endpoints in keratinocyte cell cultures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2002 journal article
Gulf War related exposure factors influencing topical absorption of 14C-permethrin
Toxicology Letters, 135(1-2), 61–71.
Contributors: J. Riviere n, n & R. Baynes n
author keywords: permethrin; Gulf War; JP-8; jet fuel; sulfur mustard; skin; absorption
MeSH headings : Animals; Cholinesterase Inhibitors; DEET / toxicity; Dermatologic Agents / pharmacology; Dermatologic Agents / toxicity; Environmental Exposure / adverse effects; Humans; Hydrocarbons / toxicity; In Vitro Techniques; Insect Repellents / toxicity; Insecticides / pharmacokinetics; Insecticides / toxicity; Isoflurophate / toxicity; Mustard Gas / toxicity; Permethrin / pharmacokinetics; Permethrin / toxicity; Persian Gulf Syndrome / chemically induced; Skin / drug effects; Skin / metabolism; Skin Absorption / physiology; Swine
TL;DR:
It is suggested that co-exposure to JP-8 or sulfur mustard may modulate transdermal flux of 14C-permethrin and this moderate increase in permethrin absorption remains unclear.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2002 journal article
Pyridostigmine bromide modulates the dermal disposition of [C-14]permethrin
TOXICOLOGY AND APPLIED PHARMACOLOGY, 181(3), 164–173.
Contributors: R. Baynes n, n & J. Riviere n
author keywords: permethrin; pyridostigmine bromide; skin; absorption
MeSH headings : Animals; Biological Availability; Chemical Phenomena; Chemistry, Physical; Cholinesterase Inhibitors / pharmacology; Diffusion; Drug Interactions; Female; In Vitro Techniques; Insecticides / pharmacokinetics; Isoflurophate / pharmacology; Permethrin / pharmacokinetics; Persian Gulf Syndrome; Pharmaceutical Vehicles; Pyridostigmine Bromide / pharmacology; Skin Absorption / drug effects; Swine
TL;DR:
It is suggested that intraarterial perfusion of PB and/or DFP and topical application of DFP or DEET can alter the disposition of [14C]permethrin in skin and possibly its bioavailability in soldiers simultaneously exposed to these chemicals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2002 journal article
The use of enzyme histochemistry in detecting cutaneous toxicity of three topically applied jet fuel mixtures
Toxicology Mechanisms and Methods, 12(1), 17–34.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2002 journal article
The use of enzyme histochemistry in detecting cutaneous toxicity of three topically applied jet fuel mixtures
Toxicology Mechanisms and Methods, 12(1), 17–34.
author keywords: cutaneous toxicity; histochemistry; jet fuels; pig; skin
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: June 27, 2019
2001 journal article
Analysis of interleukin-8 release from normal human epidermal keratinocytes exposed to aliphatic hydrocarbons: delivery of hydrocarbons to cell cultures via complexation with alpha-cyclodextrin
TOXICOLOGY IN VITRO, 15(6), 663–669.
Contributors: D. Allen n, J. Riviere n & n
author keywords: keratinocyte; cytokine; jet fuel; hydrocarbon; cyclodextrin
MeSH headings : Cells, Cultured; Cyclodextrins / chemistry; Dose-Response Relationship, Drug; Drug Carriers / chemistry; Humans; Hydrocarbons / chemistry; Hydrocarbons / toxicity; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / ultrastructure; Kerosene / toxicity; Solubility; alpha-Cyclodextrins
TL;DR:
These studies demonstrate that the etiology of proinflammatory cytokine expression due to jet fuel exposure may be due in large part to the aliphatic hydrocarbon components and provide additional evidence that hydrocarbons can be successfully delivered to cells in culture by encapsulating them in cyclodextrin inclusion complexes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 journal article
Cytokine induction as a measure of cutaneous toxicity in primary and immortalized porcine keratinocytes exposed to jet fuels, and their relationship to normal human epidermal keratinocytes
TOXICOLOGY LETTERS, 119(3), 209–217.
Contributors: D. Allen n, J. Riviere n & n
author keywords: immortalized keratinocyte; cytokine; jet fuel; toxicity
MeSH headings : Analysis of Variance; Animals; Biomarkers; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Female; Fuel Oils / toxicity; Humans; Interleukin-8 / biosynthesis; Keratinocytes / drug effects; Keratinocytes / metabolism; RNA, Messenger / isolation & purification; Swine; Tumor Necrosis Factor-alpha / biosynthesis
TL;DR:
The results suggest that porcine keratinocytes are susceptible to jet fuel toxicity, however, the responses of immortalized cells may vary from those of PKC and NHEK necessitating cautious interpretation of such data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 report
Dermal absorption cutting fluids
In Annual report 1R010H03669-01A2.
Source: NC State University Libraries
Added: August 6, 2018
2001 chapter
Dermatotoxicology
In E. Hodgson & R. Smart (Eds.), Introduction to biochemical toxicology (3rd ed.) (Vol. 21, pp. 509–537). NY: John Wiley & Sons.
Ed(s): . E. Hodgson & R. Smart
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
Effect of selective lipid extraction from different body regions on epidermal barrier function
PHARMACEUTICAL RESEARCH, 18(7), 992–998.
Contributors: n , A. Inman n, V. Mak*, P. Wertz & J. Riviere n
author keywords: epidermal lipids; ceramides; lipid extraction; tape stripping; transepidermal water loss (TEWL); electron microscopy; membrane lipids
MeSH headings : Abdomen; Animals; Back; Epidermis / drug effects; Epidermis / metabolism; Epidermis / physiology; Epidermis / ultrastructure; Erythema / chemically induced; Erythema / metabolism; Erythema / pathology; Female; Groin; Lipid Metabolism; Skin Absorption / drug effects; Skin Irritancy Tests / methods; Solvents / administration & dosage; Swine; Water / metabolism
TL;DR:
It is suggested that strategies that could biochemically alter epidermal lipid composition may increase absorption of simultaneously administered topical compounds and may be useful to enhance drug delivery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2001 journal article
Effects of short-term high-dose and low-dose dermal exposure to Jet A, JP-8 and JP-8 + 100 jet fuels
Journal of Applied Toxicology, 21(6), 485–494.
Contributors: n , A. Inman n & J. Riviere n
author keywords: skin; jet fuels; Jet A; JP-8; JP-8+100; dermatopathology; dermatotoxicity; pig; hydrocarbon fuels
MeSH headings : Administration, Cutaneous; Aircraft; Animals; Cell Division / drug effects; Clothing; Edema / chemically induced; Edema / pathology; Epidermis / drug effects; Epidermis / pathology; Erythema / chemically induced; Erythema / pathology; Female; Humans; Hydrocarbons / administration & dosage; Hydrocarbons / toxicity; Kerosene / toxicity; Occupational Exposure; Swine; Water-Electrolyte Balance
TL;DR:
It is found that the high‐dose fabric‐soaked exposure at 5 days to Jet A, JP‐8 andJP‐8 + 100 fuels caused the greatest increase in cutaneous erythema, edema, epidermal thickness and rete peg depth compared with high‐ dose non‐occluded or low‐dose exposure under Hill Top occluded and non-occluded conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2001 article
Efficacy of topical phenol decontamination strategies on severity of acute phenol chemical burns and dermal absorption: in vitro and in vivo studies in pig skin
Monteiro-Riviere, N. A., Inman, A. O., Jackson, H., Dunn, B., & Dimond, S. (2001, May). TOXICOLOGY AND INDUSTRIAL HEALTH, Vol. 17, pp. 95–104.
Contributors: n , A. Inman n, H. Jackson n, B. Dunn* & S. Dimond*
author keywords: chemical burns; dermal absorption; phenol; pig skin; skin decontamination
MeSH headings : Absorption; Animals; Burns, Chemical / therapy; Disease Models, Animal; Female; Phenol / adverse effects; Phenol / pharmacokinetics; Sclerosing Solutions / adverse effects; Sclerosing Solutions / pharmacokinetics; Severity of Illness Index; Skin; Soaps; Solvents; Swine; Water
TL;DR:
It was concluded that PEG 400 and 70% IPA were superior to the other treatments investigated and equally efficacious in the reduction of phenol-induced skin damage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 journal article
Electron microscopic observations of stratum corneum intercellular lipids in normal and atopic dogs
VETERINARY PATHOLOGY, 38(6), 720–723.
Contributors: A. Inman*, T. Olivry* , S. Dunston*, * & H. Gatto
author keywords: barrier defect; canine atopic dermatitis; dogs; lipid lamellae; ruthenium tetroxide
MeSH headings : Animals; Biopsy / veterinary; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Dermatitis, Atopic / veterinary; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Female; Fixatives / chemistry; Lipid Metabolism; Male; Microscopy, Electron / veterinary; Pilot Projects; Ruthenium Compounds / chemistry; Skin / metabolism; Skin / pathology; Skin / ultrastructure
TL;DR:
Preliminary observations suggest that the epidermal lipid barrier is defective in atopic canine skin and should be corrected with nutritional and/or pharmacologic intervention.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 chapter
The excretory system
In H. J. M. W. G. Pond (Ed.), Biology of the domestic pig (Vol. 13, pp. 585–624). Ithaca, NY: Comstock Pub. Associates/Cornell University Press.
Ed(s): H. W. G. Pond
Source: NC State University Libraries
Added: August 6, 2018
2001 chapter
The integument
In W. G. Pond & H. J. Mersmann (Eds.), Biology of the domestic pig (Vol. 14, pp. 625–652). Comstock Publishing Assoc.
Ed(s): . W. G. Pond & H. Mersmann
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
Topical L-ascorbic acid: Percutaneous absorption studies
DERMATOLOGIC SURGERY, 27(2), 137–142.
Contributors: . Pinnell*, H. Yang n, M. Omar, N. Riviere n, H. DeBuys*, L. Walker*, Y. Wang *, M. Levine *
MeSH headings : Administration, Cutaneous; Animals; Antioxidants / administration & dosage; Antioxidants / pharmacokinetics; Ascorbic Acid / administration & dosage; Ascorbic Acid / analogs & derivatives; Ascorbic Acid / pharmacokinetics; Dehydroascorbic Acid / administration & dosage; Dehydroascorbic Acid / pharmacokinetics; Hydrogen-Ion Concentration; Skin / metabolism; Skin Absorption; Sunscreening Agents / administration & dosage; Sunscreening Agents / pharmacokinetics; Swine
TL;DR:
Delivery of topical L-ascorbic acid into the skin is critically dependent on formulation characteristics, and formulation characteristics of ascorbic acid or its derivatives are defined to supplement the skin's natural antioxidant reservoir.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 journal article
Topical zinc sulphate - An antioxidant for skin
Journal of Investigative Dermatology, 117(2), 506. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000170668300728&KeyUID=WOS:000170668300728
Source: ORCID
Added: June 27, 2019
2001 journal article
Ultraviolet A exposure induces irradiance-dependent vascular injury in pig skin
Journal of Investigative Dermatology, 117(2), 507. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000170668300736&KeyUID=WOS:000170668300736
Source: ORCID
Added: June 27, 2019
2001 journal article
Use of methyl salicylate as a simulant to predict the percutaneous absorption of sulfur mustard
JOURNAL OF APPLIED TOXICOLOGY, 21(2), 91–99.
Contributors: J. Riviere n, C. Smith n, K. Budsaba n, J. Brooks n, E. Olajos*, H. Salem*, n
MeSH headings : Administration, Cutaneous; Adsorption; Animals; Area Under Curve; Carbon Radioisotopes; Culture Techniques; Dermatologic Agents / pharmacokinetics; Fixatives; Models, Biological; Mustard Gas / pharmacokinetics; Salicylates / pharmacokinetics; Skin / drug effects; Skin / pathology; Swine
TL;DR:
Compared with other chemicals studied in this model, HD and MS cutaneous disposition were very similar, supporting the use of MS as a dermal simulant for HD exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2000 chapter
Apparato tegumentario
In J. A. E. H. D. Dellmann & R. Bortolami (Eds.), Istologia e anatomia microscopica veterinaria (2a ed.) (pp. 408–444). Milano: Casa Editrice Ambrosiana.
Ed(s): J. H. D. Dellmann & R. Bortolami
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Characterization of sulfur mustard-induced toxicity by enzyme histochemistry in porcine skin
TOXICOLOGY METHODS, 10(2), 127–142.
Contributors: n & A. Inman n
TL;DR:
ALP staining was found to be the most sensitive of the enzyme biomarkers in this study, since its intensity increases in response to mild insult and decreases inresponse to a more severe exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2000 journal article
Comparative in vitro percutaneous absorption of nonylphenol and nonylphenol ethoxylates (NPE-4 and NPE-9) through human, porcine and rat skin
Toxicology and Industrial Health, 16(2), 49–57.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018
2000 journal article
Comparative in vitro percutaneous absorption of nonylphenol and nonylphenol ethoxylates (NPE-4 and NPE-9) through human, porcine and rat skin
Toxicology and Industrial Health, 16(2), 49–57.
Contributors: n , J. Van Miller, G. Simon, R. Joiner*, J. Brooks n & J. Riviere n
author keywords: ethoxylated nonylphenol; nonylphenol ethoxylates; skin absorption
MeSH headings : Animals; Female; Humans; Nonoxynol / pharmacokinetics; Phenols / pharmacokinetics; Rats; Rats, Sprague-Dawley; Skin / metabolism; Skin Absorption; Species Specificity; Swine
TL;DR:
Fractional absorption was concentration-dependent, making the actual absorbed flux constant across all doses, suggesting that NP, N PE-4 and NPE-9 were minimally absorbed across skin from all three species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: June 27, 2019
2000 journal article
Identification of early biomarkers of inflammation produced by keratinocytes exposed to jet fuels Jet A, JP-8, and JP-8(100)
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 14(5), 231–237.
Contributors: D. Allen n, J. Riviere n & n
author keywords: epidermal keratinocyte; cytokine; jet fuel; biomarkers; inflammation
TL;DR:
It is demonstrated that jet fuels induce the production and release of proinflammatory cytokines in NHEK and thus create the potential for chronic inflammation, which may contribute to the development or progression of disease states in the skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2000 journal article
Use of the pig as a model to assess cutaneous toxicity and inflammation of jet fuels
Journal of Veterinary Pharmacology and Therapeutics, 23(Suppl. 1 CD), F12.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Alteration of cytokeratin expression following transdermal lidocaine hydrochloride iontophoresis
PHARMACEUTICAL RESEARCH, 16(9), 1487–1490.
Contributors: D. Allen n & n
author keywords: iontophoresis; lidocaine; pig skin; cytokeratins
MeSH headings : Administration, Cutaneous; Anesthetics, Local / pharmacology; Animals; Cell Nucleus; Cytoskeleton / metabolism; Epidermis / chemistry; Epidermis / drug effects; Epidermis / metabolism; Female; Immunohistochemistry; Iontophoresis; Keratin-10; Keratins / analysis; Keratins / biosynthesis; Lidocaine / pharmacology; Swine
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1999 journal article
Dermal Absorption and Distribution of Topically Dosed Jet Fuels Jet-A, JP-8, and JP-8(100)
Toxicology and Applied Pharmacology, 160(1), 60–75.
Contributors: J. Riviere n, J. Brooks n, n , K. Budsaba n & C. Smith n
author keywords: jet fuel; naphthalene; dodecane; hexadecane; percutaneous/dermal absorption; skin
MeSH headings : Administration, Topical; Aircraft; Alkanes / pharmacokinetics; Animals; Fuel Oils; Naphthalenes / pharmacokinetics; Perfusion; Skin / metabolism; Skin Absorption; Swine
TL;DR:
Different absorption profiles for the three marker compounds, differential effects of jet fuel types on naphthalene and dodecane absorption, and uncoupling of perfusate absorption from skin disposition are demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
1999 journal article
Immunohistochemical characterization of the basement membrane epitopes in bis(2-chloroethyl) sulfide-induced toxicity in mouse ear skin
JOURNAL OF APPLIED TOXICOLOGY, 19(5), 313–328.
Contributors: n , A. Inman n, M. Babin* & R. Casillas*
author keywords: epidermal-dermal junction epitopes; immunoelectron microscopy; immunofluorescence; mouse skin; sulfur mustard; basement membrane; cutaneous toxicity; blister
TL;DR:
The immunofluorescence and IEM results indicate that HD causes an undulating inconsistent separation in the uppermost lamina lucida with focal cleavage into the lower portion of the basal keratinocytes just above the plasma membrane.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1999 conference paper
Pathway-enlarging molecules for skin electroporation: The possibility of macromolecule delivery with minimal side effects
Proceedings of the 6th Conference on Perspectives in Percutaneous Penetration. Cardiff: STS Publishing.
Source: NC State University Libraries
Added: August 6, 2018
1999 chapter
Skin Toxicology
In H. Marquardt, S. Schafer, R. McClellan, & F. Welsch (Eds.), Toxicology (pp. 439–457).
Ed(s): H. Marquardt, S. Schafer, R. McClellan & F. Welsch
TL;DR:
The mechanisms of direct irritation and sensitization are discussed to provide a basis for selecting appropriate biomarkers for evaluating dermal toxicity, and the general principles of percutaneous penetration, metabolism, and cutaneous responses to specific chemicals are provided.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
1998 conference paper
Assessment of epidermal-dermal junction epitopes in the mouse ear vesicant model
Proceedings of the 1998 Medical Defense Bioscience Review, 1–13. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Canine epidermolysis bullosa acquisita: circulating autoantibodies target the aminoterminal noncollagenous (NC1) domain of collagen VII in anchoring fibrils
VETERINARY DERMATOLOGY, 9(1), 19–31.
Contributors: T. Olivry n , J. Fine*, S. Dunston n, D. Chasse n, A. Tenorio*, n , M. Chen *, D. Woodley *
author keywords: epidermolysis bullosa acquisita; dog; canine; collagen VII; anchoring fibril; blistering disease; autoimmunity
TL;DR:
This study establishes the existence of the canine equivalent of epidermolysis bullosa acquisita (EBA) in humans, and confirms that the circulating autoantibodies are specific for the aminoterminal globular non-collagenous NC1 domain of type VII collagen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1998 conference paper
Frontiers in in vitro and in vivo assessment of cutaneous toxicity models for risk assessment
Continuing education course syllabus for the 37th annual meeting of the Society of Toxicology, Seattle, WA, March, 1998, (1998 Mar.).
Source: NC State University Libraries
Added: August 6, 2018
1998 conference paper
In vitro and in vivo assessment of cutaneous toxicity models
Continuing Education Course Syllabus for the 37th Annual Meeting of the Society of Toxicology, 37.
Source: NC State University Libraries
Added: August 6, 2018
1998 chapter
The Integument
In H. D. Dellmann & J. A. Eurell (Eds.), Textbook of veterinary histology. (5th ed.) (pp. 303–332). Baltimore: Williams & Wilkins.
Ed(s): . H. D. Dellmann & J. Eurell
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Uncein may be a potential target for sulfur mustard alkylation
TOXICOLOGY METHODS, 8(1), 27–36.
author keywords: basement membrane; blister; cell culture; epidermal-dermal junction; keratinocytes; sulfur mustard; uncein; vesication
TL;DR:
Uncein is a newly discovered anchoring filament-associated antigen that has been shown to be undetectable in all forms of junctional epidermolysis bullosa, therefore suggesting its role in maintaining the integrity of the epidermal-dermal basement membrane zone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1997 journal article
Comparison of an in vitro skin model to normal human skin for dermatological research
MICROSCOPY RESEARCH AND TECHNIQUE, 37(3), 172–179.
Contributors: N. MonteiroRiviere n, A. Inman n, T. Snider*, J. Blank* & D. Hobson *
author keywords: in vitro skin model; human skin; viability; cell culture; electron microscopy; morphology; skin
TL;DR:
The EpiDerm™ HSE, although exhibiting slight differences, was morphologically and biochemically similar to normal human epidermis and may be a valuable model in assessing the toxicology, metabolism, or pharmacology of nonvesicating compounds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1997 journal article
Comparison of integrins in human skin, pig skin, and perfused skin: An in vitro skin toxicology model
JOURNAL OF APPLIED TOXICOLOGY, 17(4), 247–253.
Contributors: Z. Zhang n & N. MonteiroRiviere n
author keywords: human skin, integrin; in vitro; isolated perfused skin; pig skin; vesication; wound healing
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1997 journal article
Comparison of integrins in human skin, pig skin, and perfused skin: An in vitro skin toxicology model
Journal of Applied Toxicology, 17(4), 247–253.
Contributors: Z. Zhang n & n
TL;DR:
The pig and theIPPSF prove to be ideal models to study the role of integrins in wound healing and blistering diseases occurring at the epidermal–dermal junction, and the distribution of α6β4 in the IPPSF blisters caused by HD is comparable to that of some human basement membrane blistering disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 25, 2022
1997 journal article
Cutaneous toxicity of the benzidine dye direct red 28 applied as mechanistically-defined chemical mixtures (MDCM) in perfused porcine skin
Toxicology Letters, 93(2-3), 159–169.
Contributors: R. Baynes n, n , G. Qiao n & J. Riviere n
author keywords: chemical mixtures; cutaneous toxicity; benzidine dye
MeSH headings : Animals; Benzidines / pharmacokinetics; Benzidines / toxicity; Biomarkers; Coloring Agents / pharmacokinetics; Coloring Agents / toxicity; Dermotoxins / adverse effects; Dermotoxins / pharmacokinetics; Hazardous Waste / adverse effects; In Vitro Techniques; Perfusion; Skin Absorption; Solvents / pharmacokinetics; Solvents / toxicity; Surface-Active Agents / pharmacokinetics; Surface-Active Agents / toxicity; Swine; Toxicity Tests
TL;DR:
It is demonstrated that various mixtures, especially those containing SLS alter the epidermal barrier differently with complex interactions occurring simultaneously.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
1997 journal article
Enzyme histochemical evaluation of current application in pig skin
Pharmaceutical Research (New York), 14(11 SUPPL.), S307. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BIOSIS&KeyUT=BIOSIS:PREV199800104918&KeyUID=BIOSIS:PREV199800104918
Source: ORCID
Added: June 27, 2019
1997 journal article
Epidermal cytotoxicity of topically-applied chemical mixtures in perfused porcine skin
Journal of Veterinary Pharmacology and Therapeutics, 20(SUPPL. 1), 255–256. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BIOSIS&KeyUT=BIOSIS:PREV199799683390&KeyUID=BIOSIS:PREV199799683390
Source: ORCID
Added: June 27, 2019
1997 journal article
Glut-1: Cardiac expression during organogenesis and its role in glucose uptake in embryonic mouse heart
FASEB Journal, 11(3). http://www.scopus.com/inward/record.url?eid=2-s2.0-33750120598&partnerID=MN8TOARS
Source: ORCID
Added: September 25, 2022
1997 article
Introduction to histological aspects of dermatotoxicology
MonteiroRiviere, N. A. (1997, May 1). MICROSCOPY RESEARCH AND TECHNIQUE, Vol. 37, pp. 171–171.
Contributors: N. MonteiroRiviere n
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1997 report
Percutaneous absorption of volatile chemicals
In (NTIS report AFOSR G49620-95-1-0017) (pp. 1–23).
TL;DR:
These studies demonstrated dose-dependent absorption of CPFB and DCB in skin which was further modulated by concomitant exposure to vehicle, and could be used as direct input into a systemic risk assessment model.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
1997 journal article
The effect of altered media flow and glucose concentration on sulfur mustard toxicity in the Isolated Perfused Porcine Skin Flap
In Vitro and Molecular Toxicology: Journal of Basic and Applied Research, 10(2), 169–181. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030818496&partnerID=MN8TOARS
Source: ORCID
Added: September 25, 2022
1997 journal article
The effects of altered media flow and glucose concentration on sulfur mustard toxicity in isolated perfused skin
In Vitro Toxicology, 10(2), 169–181.
Source: NC State University Libraries
Added: August 6, 2018
1997 chapter
Transdermal peptide delivery using electroporation
In L. M. Sanders & R. W. Hendren (Eds.), Protein delivery: Physical systems (pp. 213–238).
Ed(s): . L. M. Sanders & R. Hendren
MeSH headings : Administration, Cutaneous; Animals; Biological Transport; Calcitonin / administration & dosage; Electroporation / adverse effects; Gonadotropin-Releasing Hormone / administration & dosage; Insulin / administration & dosage; Lipid Bilayers / chemistry; Neurotensin / administration & dosage; Peptides / administration & dosage; Skin / metabolism; Swine; Vasopressins / administration & dosage
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
1997 journal article
Transdermal peptide delivery using electroporation.
Pharmaceutical Biotechnology, 10, 213–238. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:9160374&KeyUID=MEDLINE:9160374
Source: ORCID
Added: June 27, 2019
1997 journal article
Ultrastructural characterization of sulfur mustard-induced vesication in isolated perfused porcine skin
MICROSCOPY RESEARCH AND TECHNIQUE, 37(3), 229–241.
Contributors: N. MonteiroRiviere n & A. Inman n
author keywords: microvesicle; blisters; sulfur mustard (bis(2-chloroethyl) sulfide); isolated perfused skin; vesication; histology; in vitro; skin; toxicology; pig; ultrastructure
TL;DR:
The IPPSF appears to be an appropriate in vitro model with which to study the pathogenesis of vesicant‐induced toxicity and appeared similar to human skin exposed to HD with the formation of macroscopic blisters and microscopic vesicles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1996 chapter
Anatomical factors affecting percutaneous absorption
In F. N. Marzulli & H. I. Maibach (Eds.), Dermatotoxicology (5th ed.) (pp. 3–17). Washington, DC: Taylor & Francis.
Ed(s): . F. N. Marzulli & H. Maibach
Source: NC State University Libraries
Added: August 6, 2018
1996 conference paper
Integrated biochemical and molecular mechanisms of sulfur mustard vesication in skin: vascular and basement membrane targets
Proceedings of the 1996 Medical Defense Bioscience Review, 977–986. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.
Source: NC State University Libraries
Added: August 6, 2018
1996 patent
Iontophoretic electrode
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1996 chapter
Swine research breeds, methods, and biomedical models
In M. E. Tumbleson & L. B. Schook (Eds.), Advances in swine in biomedical research (pp. 423–424).
Ed(s): . M. E. Tumbleson & L. Schook
TL;DR:
The growing acceptance of swine as a standard laboratory animal is due largely to the development, characterization and widespread availability of specialized pigs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
1996 journal article
Temperature regulation in adult hamsters and rats exposed perinatally to dioxin
FASEB Journal, 10(3), A4. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BIOSIS&KeyUT=BIOSIS:PREV199698763275&KeyUID=BIOSIS:PREV199698763275
Source: ORCID
Added: June 27, 2019
1996 chapter
The pig as a model for cutaneous pharmacology and toxicology research
In M. E. Tumbleson & L. B. Schook (Eds.), Advances in swine in biomedical research (pp. 425–458).
Ed(s): . M. E. Tumbleson & L. Schook
TL;DR:
The pig has been a well accepted model for cutaneous absorption and toxicity studies because the integument is morphologically and functionally similar to human skin, and how the pig is utilized in this field is reviewed, with particular reference to studies conducted in the laboratory.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
1996 journal article
The use of mechanistically defined chemical mixtures (MDCM) to assess component effects on the percutaneous absorption and cutaneous disposition of topically exposed chemicals .1. Studies with parathion mixtures in isolated perfused porcine skin
TOXICOLOGY AND APPLIED PHARMACOLOGY, 141(2), 473–486.
Contributors: G. Qiao n, J. Brooks n, R. Baynes n, N. MonteiroRiviere n, P. Williams n & J. Riviere n
MeSH headings : Animals; Dimethyl Sulfoxide / pharmacology; Female; Insecticides / pharmacokinetics; Parathion / pharmacokinetics; Perfusion; Risk Assessment; Skin / blood supply; Skin / metabolism; Skin Absorption; Surface-Active Agents / pharmacology; Swine
TL;DR:
This study indicated multiple levels of interactive effects on PA absorption which must be incorporated into any effort to identify critical mechanisms which affect risk assessment of topically exposed mixtures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1996 journal article
The use of mechanistically defined chemical mixtures (MDCM) to assess mixture component effects on the percutaneous absorption and cutaneous disposition of topically exposed chemicals .2. Development of a general dermatopharmacokinetic model for use in risk assessment
TOXICOLOGY AND APPLIED PHARMACOLOGY, 141(2), 487–496.
Contributors: P. Williams n, D. Thompson n, G. Qiao n, N. MonteiroRiviere n & J. Riviere n
MeSH headings : Animals; Models, Biological; Perfusion; Risk Assessment; Skin / metabolism; Skin Absorption; Swine
TL;DR:
This model supports the MDCM concept that defining and then simulating those components of a complex mixture that could have a significant impact on the absorption of a marker toxic compound would be a useful screening approach in the risk assessment of topical chemical mixtures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1995 journal article
ASSESSMENT OF SULFUR MUSTARD INTERACTION WITH BASEMENT-MEMBRANE COMPONENTS
CELL BIOLOGY AND TOXICOLOGY, 11(2), 89–101.
Contributors: Z. Zhang n, B. Peters n & N. Monteiroriviere n
author keywords: ADHESION; ALKYLATION; BASEMENT MEMBRANE; KERATINOCYTE; SULFUR MUSTARD; VESICATION
MeSH headings : Alkylating Agents / toxicity; Basement Membrane / drug effects; Basement Membrane / metabolism; Blister / chemically induced; Cell Adhesion / drug effects; Cells, Cultured; Cross-Linking Reagents / toxicity; Cysteine / pharmacology; Dermatologic Agents / antagonists & inhibitors; Dermatologic Agents / toxicity; Fibronectins / chemistry; Fibronectins / drug effects; Fibronectins / metabolism; Heparan Sulfate Proteoglycans; Heparitin Sulfate / chemistry; Heparitin Sulfate / metabolism; Heparitin Sulfate / physiology; Humans; Keratinocytes / drug effects; Keratinocytes / metabolism; Laminin / chemistry; Laminin / drug effects; Laminin / metabolism; Mustard Gas / toxicity; Proteoglycans / chemistry; Proteoglycans / metabolism; Proteoglycans / physiology; Thiosulfates / pharmacology
TL;DR:
The hypothesis that the alkylation of basement membrane components by HD destabilizes the epidermal-dermal junction in the process of HD-induced vesication is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1995 journal article
DETECTION OF SULFUR MUSTARD BIS(2-CHLOROETHYL) SULFIDE AND METABOLITES AFTER TOPICAL APPLICATION IN THE ISOLATED-PERFUSED PORCINE SKIN FLAP
LIFE SCIENCES, 56(17), 1385–1394.
Contributors: J. Spoo n, N. Monteiroriviere n & J. Riviere n
author keywords: PIG SKIN; IPPSF; SULFUR MUSTARD; THIODIGLYCOL
TL;DR:
Experiments showed that little, if any, HD appears in the venous perfusate intact after percutaneous absorption and that epidermal metabolism of HD does occur to a significant degree in the IPPSF.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1995 journal article
ENHANCING OR BLOCKING EFFECT OF FENVALERATE ON THE SUBSEQUENT PERCUTANEOUS-ABSORPTION OF PESTICIDES IN-VITRO
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 51(3), 214–219.
TL;DR:
The total absorption of these pesticides, both ethanol control and fenvalerate or parathion pretreated, increased proportionally with the dose; however, the absorption efficiency (fraction of applied dose absorbed) decreased as the dose increased.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1995 journal article
EVALUATION OF PROTECTIVE EFFECTS OF SODIUM THIOSULFATE, CYSTEINE, NIACINAMIDE AND INDOMETHACIN ON SULFUR MUSTARD-TREATED ISOLATED-PERFUSED PORCINE SKIN
CHEMICO-BIOLOGICAL INTERACTIONS, 96(3), 249–262.
Contributors: Z. Zhang n, J. Riviere n & N. Monteiroriviere n
author keywords: SULFUR MUSTARD; SODIUM THIOSULFATE; CYSTEINE; NIACINAMIDE; INDOMETHACIN; ISOLATED PERFUSED SKIN; TOXICOLOGY
MeSH headings : Animals; Cysteine / pharmacology; Dinoprostone / metabolism; Female; Indomethacin / pharmacology; Mustard Gas / toxicity; Niacinamide / pharmacology; Skin / blood supply; Skin Diseases / chemically induced; Skin Diseases / pathology; Swine; Thiosulfates / pharmacology
TL;DR:
Data suggest that none of these agents alone would be successful antivesicant agents and different mechanisms are involved in production of HD-induced dark basal cells, microvesicles and the vascular response; unfortunately, blocking of the cellular toxicity as evidenced by dark basal cell formation did not prevent vesication, suggesting that other mechanisms must be operative and that there is a multistep, biochemical process that leads to a final lesion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1995 journal article
INDIRECT IMMUNOHISTOCHEMISTRY AND IMMUNOELECTRON MICROSCOPY DISTRIBUTION OF 8 EPIDERMAL-DERMAL JUNCTION EPITOPES IN THE PIG AND IN ISOLATED-PERFUSED SKIN TREATED WITH BIS (2-CHLOROETHYL) SULFIDE
TOXICOLOGIC PATHOLOGY, 23(3), 313–325.
Contributors: N. Monteiroriviere n & A. Inman n
author keywords: PIG SKIN; IPPSF; DERMATOTOXICOLOGY; SULFUR MUSTARD; MORPHOLOGY; EPIDERMAL DERMAL JUNCTION; LAMININ; TYPE IV COLLAGEN; FIBRONECTIN; GB3; BULLOUS PEMPHIGOID; EPIDERMOLYSIS BULLOSA ACQUISITA; L3D; 19-DEJ-1
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Basement Membrane / chemistry; Basement Membrane / drug effects; Basement Membrane / ultrastructure; Collagen / analysis; Epidermolysis Bullosa Acquisita / immunology; Epitopes / analysis; Female; Fibronectins / analysis; Immunohistochemistry; In Vitro Techniques; Laminin / analysis; Microscopy, Immunoelectron; Mustard Gas / toxicity; Skin / chemistry; Skin / drug effects; Skin / ultrastructure; Swine; Trihexosylceramides / analysis
TL;DR:
P pig skin and the IPPSF may be used to study HD-induced vesication and blistering diseases and the conservation of human epitopes in the EDJ of the pig further emphasizes the similarities between human skin and pig skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
1995 journal article
Isolated perfused porcine skin flap as an in vitro model for predicting transdermal pharmacokinetics
European Journal of Pharmaceutics and Biopharmaceutics, 41, 152–162.
Source: NC State University Libraries
Added: August 6, 2018
1995 report
Mechanisms of cutaneous vesication
In N. T. I. S. (Ed.), DAMD17-92-C-2071; NTIS, ADA305800 (Vol. 161, pp. 1–161). DAMD 17-92C-2071, NTIS Report, ADA 305800.
Ed(s): Ntis
Source: NC State University Libraries
Added: August 6, 2018
1995 journal article
PULSATILE TRANSDERMAL DELIVERY OF LHRH USING ELECTROPORATION - DRUG-DELIVERY AND SKIN TOXICOLOGY
JOURNAL OF CONTROLLED RELEASE, 36(3), 229–233.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1995 journal article
Piroxicam: Evidence for local delivery following topical application
European Journal of Pharmaceutics and Biopharmaceutics, 41, 175–183.
Source: NC State University Libraries
Added: August 6, 2018
1995 article
TEMPERATURE REGULATION AND METABOLISM IN RATS EXPOSED PERINATALLY TO DIOXIN - PERMANENT CHANGE IN REGULATED BODY-TEMPERATURE
GORDON, C. J., GRAY, L. E., MONTEIRORIVIERE, N. A., & MILLER, D. B. (1995, July). TOXICOLOGY AND APPLIED PHARMACOLOGY, Vol. 133, pp. 172–176.
Contributors: C. Gordon*, L. Gray *, N. Monteiroriviere* & D. Miller*
MeSH headings : Adipose Tissue, Brown / drug effects; Adipose Tissue, Brown / metabolism; Animals; Body Temperature Regulation / drug effects; Female; Fetus / drug effects; Male; Polychlorinated Dibenzodioxins / toxicity; Pregnancy; Rats; Regional Blood Flow / drug effects; Skin / blood supply
TL;DR:
The reduction in body temperature over a wide range of TaS concomitant with normal thermoregulatory effector function suggests that perinatal exposure to TCDD results in a reduction in the regulated body temperature (i.e., decrease in set-point).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1995 journal article
TOXICOKINETICS OF TOPICAL SULFUR MUSTARD PENETRATION, DISPOSITION, AND VASCULAR TOXICITY IN ISOLATED-PERFUSED PORCINE SKIN
TOXICOLOGY AND APPLIED PHARMACOLOGY, 135(1), 25–34.
Contributors: J. Riviere n, J. Brooks n, P. Williams n & N. Monteiroriviere n
MeSH headings : Animals; Blood Volume / drug effects; Dermatologic Agents / pharmacokinetics; Dermatologic Agents / toxicity; In Vitro Techniques; Models, Biological; Mustard Gas / pharmacokinetics; Mustard Gas / toxicity; Perfusion; Skin / blood supply; Skin / drug effects; Skin Absorption / drug effects; Swine
TL;DR:
A toxicokinetic model is formulated that provides a quantitative profile of the time course of HD disposition within skin which would aid in the interpretation of mechanistic studies of vesication as well as in designing interventive antivesicant drug strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1995 journal article
Topical sulfur mustard induces changes in prostaglandins and interleukin-1-alpha in isolated perfused porcine skin
In Vitro Toxicology, 8(2), 149–158. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BIOSIS&KeyUT=BIOSIS:PREV199598461660&KeyUID=BIOSIS:PREV199598461660
Contributors: Z. Zhang, J. Riviere &
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
1994 journal article
DETERMINATION OF PHYSICOCHEMICAL PROPERTIES OF PHENOL, P-NITROPHENOL, ACETONE AND ETHANOL RELEVANT TO QUANTITATING THEIR PERCUTANEOUS-ABSORPTION IN PORCINE SKIN
Research Communications in Chemical Pathology and Pharmacology, 83(1), 61–75. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1994MV05600006&KeyUID=WOS:A1994MV05600006
Contributors: P. Williams, J. Brooks, A. Inman, N. Monteiroriviere & J. Riviere
Source: ORCID
Added: June 27, 2019
1994 journal article
DEVELOPMENT AND CHARACTERIZATION OF A NOVEL SKIN MODEL FOR CUTANEOUS PHOTOTOXICOLOGY
Photodermatology Photoimmunology & Photomedicine, 10(6), 235–243. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1994QF67500002&KeyUID=WOS:A1994QF67500002
Contributors: N. Monteiroriviere, A. Inman & J. Riviere
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
1994 journal article
Determination of physicochemical properties of phenol, p-nitrophenol, acetone and ethanol relevant to quantitating their percutaneous absorption in porcine skin
Research Communications in Chemical Pathology and Pharmacology, 83, 61–75.
Source: NC State University Libraries
Added: August 6, 2018
1994 journal article
Histological evaluation of transdermal electroporation and iontophoresis of LHRH delivery in porcine skin
Pharmaceutical Research (New York), 11(10 SUPPL.), S191. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BIOSIS&KeyUT=BIOSIS:PREV199598020099&KeyUID=BIOSIS:PREV199598020099
Source: ORCID
Added: June 27, 2019
1994 journal article
IDENTIFICATION OF THE PATHWAY OF IONTOPHORETIC DRUG-DELIVERY - LIGHT AND ULTRASTRUCTURAL STUDIES USING MERCURIC-CHLORIDE IN PIGS
PHARMACEUTICAL RESEARCH, 11(2), 251–256.
Contributors: N. Monteiroriviere n, A. Inman n & J. Riviere n
author keywords: PIGS; IONTOPHORESIS; PATHWAY; DRUG DELIVERY; MERCURIC CHLORIDE; SKIN; LIGHT MICROSCOPY; ELECTRON MICROSCOPY
MeSH headings : Animals; Epidermis / metabolism; Epidermis / ultrastructure; Female; Iontophoresis; Mercuric Chloride / administration & dosage; Mercuric Chloride / pharmacokinetics; Microscopy, Electron; Skin / metabolism; Skin / ultrastructure; Skin Absorption; Swine
TL;DR:
The electron micrographs clearly revealed that mercuric chloride traversed the intact stratum corneum via an intercellular route, having implications for iontophoretic drug delivery, since they allow visualization of the functional "pores" predicted by mathematical models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
1994 journal article
LAMININ IN THE CUTANEOUS BASEMENT-MEMBRANE AS A POTENTIAL TARGET IN LEWISITE VESICATION
Toxicology and Applied Pharmacology, 126(1), 164–173.
Contributors: . King n, B. Peters n & N. Monteiroriviere n
MeSH headings : Alkylation; Animals; Arsenic Poisoning; Arsenicals; Basement Membrane / drug effects; Basement Membrane / metabolism; Blister / chemically induced; Blister / enzymology; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Endopeptidases / metabolism; Humans; Immunohistochemistry; In Vitro Techniques; Irritants / toxicity; Laminin / drug effects; Mice; Microscopy, Immunoelectron; Perfusion; Pyridines / chemistry; Skin / drug effects; Skin / metabolism; Skin / pathology; Swine
TL;DR:
Structural components of the epidermal-dermal junction are examined as potential targets for toxicity by lewisite to provide new insights into therapeutic and prophylactic strategies against the toxicity of such compounds and contribute to a better understanding of basement membrane biochemistry.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: June 27, 2019
1994 journal article
Matrix molecules of the epidermal basement membrane as targets for chemical vesication with lewisite
Toxicology and Applied Pharmacology, 126, 164–173.
Source: NC State University Libraries
Added: August 6, 2018
1994 report
Mechanisms of cutaneous vesication
In DAMD17-92-C-2071; NTIS, ADA283085 (Vol. 114, pp. 1–114). DAMD 17-92-C-2071, NTIS Report, ADA 283085.
Source: NC State University Libraries
Added: August 6, 2018
1994 journal article
SYNERGISTIC INTERACTION BETWEEN THE NONPHORBOL ESTER-TYPE PROMOTER MIREX AND 12-O-TETRADECANOYLPHORBOL-13-ACETATE IN MOUSE SKIN TUMOR PROMOTION
CARCINOGENESIS, 15(1), 47–52.
MeSH headings : Adenine / physiology; Animals; Base Sequence; Carcinogens / toxicity; Dose-Response Relationship, Drug; Drug Synergism; Female; Genes, ras / drug effects; Genes, ras / genetics; Mice; Mice, Inbred Strains; Mirex / toxicity; Molecular Sequence Data; Mutation / drug effects; Mutation / genetics; Papilloma / chemically induced; Papilloma / genetics; Skin / drug effects; Skin Neoplasms / chemically induced; Skin Neoplasms / genetics; Tetradecanoylphorbol Acetate / toxicity; Thymidine / genetics
TL;DR:
Epidermal DNA synthesis induced by 2 nmol TPA was potentiated by mirex, further supporting a role for mireX in potentiation of epidermal TPA activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1994 journal article
Transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH): Effect of repeated administration
Pharmaceutical Research, 11(7), 1000–1003.
Contributors: M. Heit n, N. Monteiroriviere n, F. Jayes n & J. Riviere n
author keywords: IONTOPHORESIS; PEPTIDE; LHRH; TRANSDERMAL DELIVERY
MeSH headings : Administration, Cutaneous; Animals; Gonadotropin-Releasing Hormone / administration & dosage; Iontophoresis / methods; Radioimmunoassay; Swine
TL;DR:
The transdermal iontophoretic delivery of the reproductive peptide hormone, luteinizing hormone releasing hormone (LHRH) is investigated in the isolated perfused porcine skin flap model (IPPSF) in efforts to identify factors inherent to iontophile delivery that might effect the drug flux of a subsequent iontphoretic episode.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1993 journal article
Effects of formaldehyde, DMSO, benzoyl peroxide, and sodium lauryl sulfate on isolated perfused porcine skin
In Vitro Toxicology, 5, 251–260.
Source: NC State University Libraries
Added: August 6, 2018
1993 book
INTEGUMENT
In Dellmann, H.-D. Textbook of Veterinary Histology, Fourth Edition. Ix+351p. Lea and Febiger: Malvern, Pennsylvania, Usa. Illus (pp. 285–312). http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BIOSIS&KeyUT=BIOSIS:PREV199243095656&KeyUID=BIOSIS:PREV199243095656
Source: ORCID
Added: June 27, 2019
1993 article
MINIMAL ROLE OF ENHANCED CELL-PROLIFERATION IN SKIN TUMOR PROMOTION BY MIREX - A NONPHORBOL ESTER-TYPE PROMOTER
MEYER, S. A., MOSER, G. J., MONTEIRORIVIERE, N. A., & SMART, R. C. (1993, December). ENVIRONMENTAL HEALTH PERSPECTIVES, Vol. 101, pp. 265–269.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1993 chapter
Porcine Skin Flaps
In In Vitro Biological Systems (pp. 515–524).
Sources: Crossref, NC State University Libraries
Added: May 30, 2021
1993 conference paper
Studies on the pathogenesis of bis (2-chloroethyl) sulfide (HD) induced vesication in porcine skin
Proceedings of the Eighth Medical Defense Bioscience Review U.S. Army Medical Research Institute of Chemical Defense, 31–40. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.
Source: NC State University Libraries
Added: August 6, 2018
1993 journal article
TOPICAL PENETRATION OF PIROXICAM IS DEPENDENT ON THE DISTRIBUTION OF THE LOCAL CUTANEOUS VASCULATURE
Pharmaceutical Research, 10(9), 1326–1331. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1993LV52400013&KeyUID=WOS:A1993LV52400013
Contributors: N. Monteiroriviere, A. Inman, J. Riviere, S. Mcneill & M. Francoeur
Source: ORCID
Added: June 27, 2019
1993 journal article
Topical penetration of piroxicam is dependent on the distribution of the local cutaneous vasculature
Pharmaceutical Research, 10, 1326–1331.
MeSH headings : Animals; Diffusion; Female; Piroxicam / pharmacokinetics; Regional Blood Flow / physiology; Skin / blood supply; Skin Absorption / physiology; Swine
TL;DR:
In conclusion, local delivery of topical drugs occurs independent of systemic absorption and the nature of the cutaneous vasculature at different sites must be taken into consideration for optimal delivery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018
1992 journal article
A new hypothesis for the mechanism of local enhanced delivery of topically applied drugs to the underlying musculature
Pharmaceutical Research (New York), 9(10 SUPPL.), S169. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BIOSIS&KeyUT=BIOSIS:PREV199344034170&KeyUID=BIOSIS:PREV199344034170
Source: ORCID
Added: June 27, 2019
1992 journal article
CHARACTERIZATION OF LEWISITE TOXICITY IN ISOLATED PERFUSED SKIN
TOXICOLOGY AND APPLIED PHARMACOLOGY, 116(2), 189–201.
Contributors: . King n, J. Riviere n & N. Monteiroriviere n
MeSH headings : Administration, Topical; Animals; Arsenic / blood; Arsenic Poisoning; Arsenicals / pharmacokinetics; Female; Glucose / metabolism; Histocytochemistry; In Vitro Techniques; Kinetics; L-Lactate Dehydrogenase / drug effects; L-Lactate Dehydrogenase / metabolism; Microscopy; Perfusion; Skin / blood supply; Skin / drug effects; Skin / metabolism; Skin Absorption; Swine; Time Factors; Vascular Resistance / drug effects
TL;DR:
The sensitivity of the IPPSF to L exposure and the similarity of lesions to those described for humans suggests that this model provides a relevant in vitro model with which to study mechanisms of chemical vesication and arsenic toxicity, as well as protective and therapeutic intervention for vesicant exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1992 journal article
CUTANEOUS TOXICITY AND ABSORPTION OF PARAQUAT IN PORCINE SKIN
TOXICOLOGY AND APPLIED PHARMACOLOGY, 115(1), 89–97.
Contributors: V. Srikrishna n, J. Riviere n & N. Monteiroriviere n
MeSH headings : Acid Phosphatase / metabolism; Alkaline Phosphatase / metabolism; Animals; Edema / chemically induced; Esterases / metabolism; Female; Glucose / metabolism; In Vitro Techniques; Microscopy, Electron; Paraquat / pharmacokinetics; Paraquat / toxicity; Skin / drug effects; Skin / metabolism; Skin / ultrastructure; Skin Absorption; Swine
TL;DR:
At high concentrations and prolonged exposure, paraquat may have deleterious effects on epidermal morphology in the absence of significant percutaneous absorption and Radiotracer studies indicated that a majority of the compound remained on top of the application site and minimal absorption or penetration into skin was observed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1992 journal article
DETERMINATION OF LIDOCAINE CONCENTRATIONS IN SKIN AFTER TRANSDERMAL IONTOPHORESIS - EFFECTS OF VASOACTIVE DRUGS
PHARMACEUTICAL RESEARCH, 9(2), 211–214.
Contributors: J. Riviere n, N. Monteiroriviere n & A. Inman n
author keywords: LIDOCAINE; IONTOPHORESIS; TRANSDERMAL; PERCUTANEOUS ABSORPTION; SKIN DEPOT
MeSH headings : Administration, Cutaneous; Animals; Electrodes; Female; Iontophoresis; Lidocaine / analysis; Lidocaine / pharmacokinetics; Models, Biological; Norepinephrine / pharmacology; Skin / anatomy & histology; Skin / chemistry; Skin / drug effects; Skin Absorption / drug effects; Swine / metabolism; Tolazoline / pharmacology; Vasoconstrictor Agents / pharmacology; Vasodilator Agents / pharmacology
TL;DR:
The hypothesis that coiontophoresis of vasoactive drugs modulates the transdermal delivery of lidocaine, in part by altering the cutaneous “depot,” is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1992 journal article
ENZYMATIC AND IMMUNOHISTOCHEMICAL STUDIES ON THE ROLE OF CYTOCHROME-P450 AND THE FLAVIN-CONTAINING MONOOXYGENASE OF MOUSE SKIN IN THE METABOLISM OF PESTICIDES AND OTHER XENOBIOTICS
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 43(1), 53–66.
Contributors: K. Venkatesh n, P. Levi n, A. Inman n, N. Monteiroriviere n, R. Misra n & E. Hodgson n
TL;DR:
Although the overall phorate sulfoxidation rate in mouse skin microsomes was only 3 to 4% of the rate seen in liver, FMO appears to assume a greater relative role to P450 in the metabolic processes in skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1992 conference paper
Effect of vehicle and application site on absorption of chemicals through equine skin
Proceedings, 38th Annual Convention of the American Association of Equine Practitioners, 38, 725.
Source: NC State University Libraries
Added: August 6, 2018
1992 journal article
LANGERHANS CELL GRANULES IN PORCINE EPIDERMIS
Journal of Anatomy, 180, 555–556. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1992JK80100018&KeyUID=WOS:A1992JK80100018
Contributors: N. Monteiroriviere
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
1992 chapter
The integument
In Textbook of veterinary histology. (4th ed.) (pp. 285–312). Philadelphia: Lea & Febiger.
Source: NC State University Libraries
Added: August 6, 2018
1992 journal article
The use of isolated perfused skin in dermatotoxicology
In Vitro Toxicology, 5, 219–233.
Source: NC State University Libraries
Added: August 6, 2018
1991 journal article
CUTANEOUS LASER-DOPPLER VELOCIMETRY IN 9 ANIMAL SPECIES
American Journal of Veterinary Research, 52(12), 1960–1964. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991GT51300007&KeyUID=WOS:A1991GT51300007
Contributors: T. Manning, N. Monteiroriviere, D. Bristol & J. Riviere
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
1991 conference paper
Characterization of lewisite vesication in isolated perfused porcine skin
Proceedings of the 1991 Medical Defense Bioscience Review, 167–170. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.
Source: NC State University Libraries
Added: August 6, 2018
1991 conference paper
Characterization of the cutaneous vascular response to topically applied sulfur mustard and lewisite
Proceedings of the 1991 Medical Defense Bioscience Review, 163–166. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.
Source: NC State University Libraries
Added: August 6, 2018
1991 chapter
Comparative anatomy, physiology, and biochemistry of mammalian skin
In Dermal and ocular toxicology: Fundamentals and methods (pp. 3–71). Boca Raton, FL: CRC Press.
Source: NC State University Libraries
Added: August 6, 2018
1991 report
Cutaneous toxicity of mustard and lewisite on the isolated perfused porcine skin flap
In DAMD17-87-C-7139; NTIS, ADA254419 (pp. 1–140).
Source: NC State University Libraries
Added: August 6, 2018
1991 journal article
DEVELOPMENT OF SURGICAL TECHNIQUES FOR PREPARATION OF INVITRO-ISOLATED PERFUSED PORCINE SKIN FLAPS FOR PERCUTANEOUS-ABSORPTION STUDIES
American Journal of Veterinary Research, 52(1), 75–82. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991ER42900016&KeyUID=WOS:A1991ER42900016
Contributors: K. Bowman, N. Monteiroriviere & J. Riviere
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
1991 journal article
Effects of organic solvent vehicles on the viability and morphology of isolated perfused porcine skin
Toxicology (Amsterdam, Netherlands), 69(1), 11–26.
Contributors: . King n & N. Monteiroriviere n
MeSH headings : Acetone / toxicity; Animals; Cyclohexanes / toxicity; Dimethyl Sulfoxide / toxicity; Ethanol / toxicity; Female; Glucose / metabolism; In Vitro Techniques; L-Lactate Dehydrogenase / metabolism; Microscopy, Electron; Pharmaceutical Vehicles / toxicity; Skin / drug effects; Skin / ultrastructure; Solvents / toxicity; Swine; Toluene / toxicity; Vascular Resistance / drug effects
TL;DR:
The IPPSF allowed the evaluation of subtle biochemical, vascular, and morphological changes associated with non-occlusive topical exposure to these organic solvents, and the necessity of documenting vehicle effects which might mask or otherwise alter subtle, but potentially important, compound-specific responses.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018
1991 journal article
IDENTIFICATION OF THE PATHWAY OF TRANSDERMAL IONTOPHORETIC DRUG DELIVERY ULTRASTRUCTURAL STUDIES USING MERCURIC CHLORIDE IN-VIVO IN PIGS
Pharmaceutical Research (New York), 8(10 SUPPL), S141. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BIOSIS&KeyUT=BIOSIS:PREV199242016040&KeyUID=BIOSIS:PREV199242016040
Source: ORCID
Added: June 27, 2019
1991 journal article
LASER DOPPLER MEASUREMENTS OF CUTANEOUS BLOOD-FLOW IN AGING MICE AND RATS
TOXICOLOGY LETTERS, 57(3), 329–338.
Contributors: N. Monteiroriviere n, Y. Banks* & L. Birnbaum *
author keywords: MICE; RATS; AGING; BLOOD FLOW; LASER DOPPLER; SKIN
MeSH headings : Aging / physiology; Animals; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Inbred F344; Regional Blood Flow; Rheology; Skin / blood supply
TL;DR:
Age differences in epidermal and dermal thickness, and blood flow of M and R occur and should be considered when evaluating cutaneous toxicity studies in different-aged animals and may potentially alter dermal absorption and/or distribution of xenobiotics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1991 conference paper
Mustard induced vesication in isolated perfused skin: Biochemical, physiological, and morphological studies
Proceedings of the 1991 Medical Defense Bioscience Review, 159–162. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.
Source: NC State University Libraries
Added: August 6, 2018
1991 journal article
THE EFFECTS OF SODIUM HYDROXIDE AND HYDROCHLORIC ACID ON ISOLATED PERFUSED SKIN
In Vitro Toxicology, 4(3), 207–216. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BIOSIS&KeyUT=BIOSIS:PREV199293071955&KeyUID=BIOSIS:PREV199293071955
Source: ORCID
Added: June 27, 2019
1991 journal article
THE ISOLATED PERFUSED EQUINE SKIN FLAP - PREPARATION AND METABOLIC PARAMETERS
VETERINARY SURGERY, 20(6), 424–433.
Contributors: D. Bristol*, J. Riviere n, N. Monteiroriviere n, K. Bowman & R. Rogers n
MeSH headings : Abdomen; Animals; Dermatologic Surgical Procedures; Glucose / metabolism; Horses / metabolism; Horses / surgery; Lactates / metabolism; Perfusion / veterinary; Saphenous Vein / physiology; Skin / blood supply; Skin / metabolism; Surgical Flaps / veterinary
TL;DR:
Results indicate that conclusions drawn from cutaneous physiology studies should not be extrapolated across species lines and that site-specific skin should be used forcutaneous physiology, pharmacology, and toxicology studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1991 review
THE ISOLATED PERFUSED PORCINE SKIN FLAP AS AN INVITRO MODEL FOR PERCUTANEOUS-ABSORPTION AND CUTANEOUS TOXICOLOGY
[Review of ]. CRITICAL REVIEWS IN TOXICOLOGY, 21(5), 329–344.
Contributors: J. Riviere n & N. Monteiroriviere n
author keywords: PERCUTANEOUS ADSORPTION; INVITRO MODEL; SKIN; CUTANEOUS TOXICOLOGY; DERMATOTOXICOLOGY; DERMATOPHARMACOLOGY; ISOLATED PERFUSED PORCINE SKIN FLAP; VESICANTS; PHARMACOKINETICS; TRANSDERMAL DRUG DELIVERY; IONTOPHORESIS; CUTANEOUS METABOLISM
MeSH headings : Animals; In Vitro Techniques; Skin / pathology; Skin Absorption / drug effects; Skin Absorption / physiology; Skin Diseases / chemically induced; Skin Diseases / pathology; Skin Physiological Phenomena; Swine
TL;DR:
The isolated perfused porcine skin flap (IPPSF) is a new perfused skin model which allows in vitro cutaneous pharmacology and toxicology studies to be conducted in a viable skin preparation which has a normal anatomical structure and a functional microcirculation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1991 journal article
The effects of sodium hydroxide and hydrochloric acid on isolated perfused skin
In Vitro Toxicology, 4, 207–215.
Source: NC State University Libraries
Added: August 6, 2018
1990 journal article
ALTERED EPIDERMAL MORPHOLOGY SECONDARY TO LIDOCAINE IONTOPHORESIS - INVIVO AND INVITRO STUDIES IN PORCINE SKIN
FUNDAMENTAL AND APPLIED TOXICOLOGY, 15(1), 174–185.
Contributors: N. Monteiroriviere n
TL;DR:
Lidocaine iontophoresis can induce in swine a unique dose-dependent non-immune-mediated epidermal alteration which is expected to have minimal toxicological significance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1990 journal article
CUTANEOUS TOXICITY OF 2-CHLOROETHYL METHYL SULFIDE IN ISOLATED PERFUSED PORCINE SKIN
TOXICOLOGY AND APPLIED PHARMACOLOGY, 104(1), 167–179.
Contributors: . King n & N. Monteiroriviere n
MeSH headings : Animals; Female; Glucose / metabolism; Microscopy, Electron; Models, Biological; Perfusion; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Diseases / chemically induced; Sulfides / toxicity; Swine
TL;DR:
Full characterization of the morphological and biochemical changes seen after topical exposure of the IPPSF to vesicants may shed light on the pathogenesis of cutaneous toxicity of these compounds in vivo and serve as a relevant model to assess protective strategies against vESicant exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1990 report
Cutaneous toxicity of mustard and lewisite on the isolated perfused porcine skin flap
In DAMD17-87-C-7139; NTIS, ADA 229922 (pp. 1–144). NTIS.
Source: NC State University Libraries
Added: August 6, 2018
1990 journal article
DIFFERENTIAL DOWN-REGULATION OF EPIDERMAL PROTEIN-KINASE-C BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE AND DIACYLGLYCEROL - ASSOCIATION WITH EPIDERMAL HYPERPLASIA AND TUMOR PROMOTION
Cancer Research, 50(18), 5740–5745. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1990DY41800007&KeyUID=WOS:A1990DY41800007
Contributors: L. Hansen, N. Monteiroriviere & R. Smart
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
1990 journal article
INTERSPECIES AND INTERREGIONAL ANALYSIS OF THE COMPARATIVE HISTOLOGIC THICKNESS AND LASER DOPPLER BLOOD-FLOW MEASUREMENTS AT 5 CUTANEOUS SITES IN 9 SPECIES
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 95(5), 582–586.
Contributors: N. Monteiroriviere n, D. Bristol n, T. Manning n, R. Rogers n & J. Riviere n
MeSH headings : Animals; Blood Flow Velocity / physiology; Cats; Cattle; Dogs; Horses; Macaca mulatta; Mice; Mice, Inbred Strains; Rabbits; Rats; Rats, Inbred Strains; Skin / cytology; Skin / diagnostic imaging; Skin Physiological Phenomena; Species Specificity; Swine; Ultrasonics; Ultrasonography
TL;DR:
The data indicate that thickness and LDV blood flow are independent and must be evaluated separately when comparisons are made between species and body sites, and provides a data base for future comparative studies in which a knowledge of skin thickness or blood flow might be important variables.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1990 chapter
Percutaneous absorption of pesticides in the isolated perfused porcine skin flap (IPPSF)
In R. E. W. Halliwell & C. Tscharner (Eds.), Advances in veterinary dermatology. Vol. 1 (pp. 299–307). London: Balliere-Tindall.
Ed(s): R. Halliwell & C. Tscharner
Source: NC State University Libraries
Added: August 6, 2018
1990 chapter
Specialized technique: Isolated perfused porcine skin flap
In B. W. Kemppainen & W. G. Reifenrath (Eds.), Methods for skin absorption (pp. 175–189). Boca Raton, FL: CRC Press.
Ed(s): B. Kemppainen & W. Reifenrath
Source: NC State University Libraries
Added: August 6, 2018
1989 article
TRANSDERMAL LIDOCAINE IONTOPHORESIS IN ISOLATED PERFUSED PORCINE SKIN
JOURNAL OF TOXICOLOGY-CUTANEOUS AND OCULAR TOXICOLOGY, Vol. 8, pp. 493–504.
TL;DR:
The isolated perfused porcine skin flap is an alternative animal model for quantitatively assessing percutaneous drug absorption and the dynamics of transdermal delivery using iontophoresis are investigated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, Web Of Science
Added: August 6, 2018
1989 conference paper
The dermatotoxicity of 2- chloroethyl methyl sulfide and solvent vehicles in isolated perfused porcine skin
Proceedings of the 1989 Medical Defense Bioscience Review, 53–56. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.
Source: NC State University Libraries
Added: August 6, 2018
1988 journal article
COMPARISON OF THE EFFECT OF SN-1,2-DIDECANOYLGLYCEROL AND 12-O-TETRADECANOYLPHORBOL-13-ACETATE ON CUTANEOUS MORPHOLOGY, INFLAMMATION AND TUMOR PROMOTION IN CD-1 MICE
CARCINOGENESIS, 9(12), 2221–2226.
Contributors: R. Smart n , M. Huang*, N. Monteiroriviere, C. Wong*, K. Mills & A. Conney*
MeSH headings : Animals; Carcinogens; Diglycerides / toxicity; Edema / chemically induced; Enzyme Induction; Female; Glycerides / toxicity; Hyperplasia / chemically induced; Mice; Ornithine Decarboxylase / biosynthesis; Skin / drug effects; Skin / enzymology; Skin / pathology; Skin Neoplasms / chemically induced; Tetradecanoylphorbol Acetate / toxicity
TL;DR:
It was determined that topical application of 2.5 or 10 mumol of sn-1,2-didecanoylglycerol induced epidermal ornithine decarboxylase activity to about the same extent as the application of 1 or 2 nmol of TPA, but it did not cause morphological changes in the epidermis when applied once or when applied twice a week for 4 weeks and did not function as a complete tumor promoter.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1988 journal article
INVITRO PENETRATION OF PESTICIDES THROUGH HUMAN NEWBORN FORESKIN
TOXICOLOGY LETTERS, 40(3), 233–239.
Contributors: H. Shehatakaram n, N. Monteiroriviere n & F. Guthrie n
MeSH headings : Epidermis / metabolism; Humans; In Vitro Techniques; Infant, Newborn; Male; Pesticides / pharmacokinetics; Skin Absorption
TL;DR:
The in vitro dermal penetration of 14C-labelled parathion, fenvalerate, carbofuran, and lindane through fresh full-thickness human newborn foreskin was determined and no difference was noted in the penetration of pesticides through human skin from blacks and whites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1987 journal article
A METHOD FOR PREPARING MOUSE SKIN FOR ASSESSING INVITRO DERMAL PENETRATION OF XENOBIOTICS
TOXICOLOGY LETTERS, 36(3), 251–258.
Contributors: R. Grissom*, N. Monteiroriviere * & F. Guthrie
MeSH headings : Administration, Topical; Animals; Female; Methods; Mice; Mice, Inbred ICR; Microbial Collagenase; Microscopy, Electron, Scanning; Skin / cytology; Skin / ultrastructure; Skin Absorption; Trypsin
TL;DR:
Morphologically, the skins prepared for in vitro use appeared to offer similar barriers to topically applied compounds as those found in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1987 report
Development of in vitro isolated perfused porcine skin flaps for study of percutaneous absorption of xenobiotics
In DAMD17-84-C-4103, NTIS, ADA 204615 (pp. 1–126).
TL;DR:
The research resulted in a reproducible perfusion model optimized for the xenobiotic absorption studies to be conducted in the second year, which would be an humane alternative animal model for studies in cutaneous toxicology, physiology, oncology, and percutaneous drug absorption and metabolism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018
1987 personal communication
ON THE DEFINITION OF VIABILITY IN ISOLATED PERFUSED SKIN PREPARATIONS
RIVIERE, J. E., BOWMAN, K. F., & MONTEIRORIVIERE, N. A. (1987, May).
Contributors: J. Riviere n, K. Bowman n & N. Monteiroriviere n
MeSH headings : Animals; Humans; In Vitro Techniques; Perfusion; Skin / metabolism; Surgical Flaps
TL;DR:
No evidence was obtained that oral indomethacin administration influences the response of psoriasis to dithranol treatment one way or the other, but there was a trend towards the indometHacin group faring better, in that the final concentration of dithrano! reached was lower, the speed of movement between concentrations was more rapid and the time to clearance was less that that in the placebo group.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1987 conference paper
Percutaneous absorption of organophosphates, steroids, caffeine and benzoic acid in vivo and in vitro using the isolated perfused porcine skin flap (IPPSF)
Proceedings of the 6th Medical Chemical Defense Bioscience Review, 763–766. Aberdeen, MD: Aberdeen Proving Ground.
Source: NC State University Libraries
Added: August 6, 2018
1987 journal article
THE ISOLATED PERFUSED PORCINE SKIN FLAP IPPSF II. ULTRASTRUCTURAL AND HISTOLOGICAL CHARACTERIZATION OF EPIDERMAL VIABILITY
In Vitro Toxicology, 1(4), 241–252. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BIOSIS&KeyUT=BIOSIS:PREV198886033485&KeyUID=BIOSIS:PREV198886033485
Source: ORCID
Added: June 27, 2019
1987 conference paper
The effects of different fixatives on the porcine integument
45th Annual Proceedings, Electron Microscopy Society of America, 948–949. San Francisco: San Francisco Press.
Source: NC State University Libraries
Added: August 6, 2018
1987 journal article
The isolated perfused porcine skin flap (IPPSF). II. Ultrastructural and histological characterization of epidermal viability
In Vitro Toxicology, 1, 241–252.
Source: NC State University Libraries
Added: August 6, 2018
1986 report
Development of in vitro isolated perfused porcine skin flaps for study of percutaneous absorption of xenobiotics
In DAMD17-84-C-4103, NTIS, ADA 198960 (pp. 1–23).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
1986 journal article
THE ISOLATED PERFUSED PORCINE SKIN FLAP (IPPSF) .1. A NOVEL INVITRO MODEL FOR PERCUTANEOUS-ABSORPTION AND CUTANEOUS TOXICOLOGY STUDIES
FUNDAMENTAL AND APPLIED TOXICOLOGY, 7(3), 444–453.
Contributors: J. Riviere n, K. Bowman n, N. Monteiroriviere n, L. Dix n & M. Carver n
MeSH headings : Animals; Blood Pressure; Glucose / metabolism; In Vitro Techniques; Models, Biological; Perfusion; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Absorption; Swine
TL;DR:
A single-pedicle, axial-pattern, island-tubed skin flap was created in crossbred Yorkshire weanling pigs in one surgical procedure, then transferred 2 or 6 days later to a computer-controlled temperature-regulated perfusion chamber for 10-to 12-hr studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1986 chapter
The isolated perfused porcine skin flap: A novel animal for cutaneous toxicologic research
In Swine in biomedical research (pp. 657–666). New York: Plenum Press.
Source: NC State University Libraries
Added: August 6, 2018
1986 journal article
ULTRASTRUCTURAL EVALUATION OF ACUTE NASAL TOXICITY IN THE RAT RESPIRATORY EPITHELIUM IN RESPONSE TO FORMALDEHYDE GAS
FUNDAMENTAL AND APPLIED TOXICOLOGY, 6(2), 251–262.
Contributors: N. Monteiroriviere * & J. Popp*
TL;DR:
Results demonstrate that short-term exposure to 6 or 15 ppm of HCHO caused respiratory epithelial injury which was not cell specific, but was dose related in severity.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1986 book
ULTRASTRUCTURE OF THE RAT NASAL MUCOSA
In Barrow, C. S. (Ed.). Chemical Industry Institute of Toxicology Series: Toxicology of the Nasal Passages; Seventh Ciit (Chemical Industry Institute Toxicology) Conference on Toxicology, Raleigh, N.c., USA, Feb. 22-23, 1984. Xvii+317p. Hemisphere Publishing Corp.: New York, N.y., USA (Dist. Outside the United States By Mcgraw-Hill International Book Co.: Auckland, N.z., Australia.) (pp. 37–50). http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BIOSIS&KeyUT=BIOSIS:PREV198732045635&KeyUID=BIOSIS:PREV198732045635
Source: ORCID
Added: April 30, 2021
1986 journal article
USE OF MIXED GLYCOSIDASE FOR THE REMOVAL OF MUCUS FROM THE RAT NASAL EPITHELIUM IN SEM STUDIES
JOURNAL OF ELECTRON MICROSCOPY TECHNIQUE, 3(4), 407–411.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1986 chapter
Ultrastructural evaluation of the porcine integument
In Swine in biomedical research (pp. 641–655). New York: Plenum Press.
Source: NC State University Libraries
Added: August 6, 2018
1986 chapter
Ultrastructure of the rat nasal mucosa
In Toxicology of the nasal passages (pp. 37–49). Washington: Hemisphere Publishing Corp.
Source: NC State University Libraries
Added: August 6, 2018
1985 journal article
DOSE-RESPONSE STUDIES OF GENTAMICIN-NEPHROTOXICITY IN RATS WITH EXPERIMENTAL RENAL DYSFUNCTION .2. POLYVINYL-ALCOHOL GLOMERULOPATHY
TOXICOLOGY AND APPLIED PHARMACOLOGY, 80(2), 264–273.
Contributors: M. Carver n, N. Monteiroriviere n, T. Brown n & J. Riviere n
MeSH headings : Animals; Carbon Radioisotopes; Gentamicins / metabolism; Gentamicins / toxicity; Glomerular Mesangium / drug effects; Glomerular Mesangium / physiology; Glomerular Mesangium / ultrastructure; Glomerulonephritis / chemically induced; Glomerulonephritis / physiopathology; Half-Life; Injections, Subcutaneous; Kidney Function Tests; Kinetics; Male; Nephrectomy; Polyvinyl Alcohol / toxicity; Rats; Rats, Inbred Strains; Tetraethylammonium; Tetraethylammonium Compounds / metabolism
TL;DR:
Altered gentamicin nephrotoxicity in rats with an otherwise benign glomerulopathy is demonstrated and similar conclusions from a related study in subtotally nephrectomized rats are presented, presenting further evidence that the underlying pathophysiologic state of the kidney is an important factor in the renal response to neph Rotoxins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1985 report
Development of in vitro isolated perfused porcine skin flaps for study of percutaneous absorption of xenobiotics
In DAMD17-84-C-4103, NTIS, ADA 183580 (pp. 1–32). Bethesda, MD: NTIS.
Source: NC State University Libraries
Added: August 6, 2018
1985 conference paper
Development of surgical techniques for in vitro isolated perfused skin flaps for percutaneous absorption of xenobiotics
Proceedings of the Fifth Annual Chemical Defense Bioscience Review. USAMRICD Report #SP 85-051, App III, A927–939. Columbia, MD: USAMRICD Report SP85 05.
Source: NC State University Libraries
Added: August 6, 2018
1985 book
MACROSCOPIC MICROSCOPIC AND ULTRASTRUCTURAL ANATOMY OF THE NASAL CAVITY RAT
In Jones, T. C., U. Mohr and R. D. Hunt (Ed.). Monographs on Pathology of Laboratory Animals. Respiratory System. Xv+240p. Springer-Verlag: Berlin, West Germany; New York, N.y., Usa. Illus (pp. 3–10). http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BIOSIS&KeyUT=BIOSIS:PREV198529049025&KeyUID=BIOSIS:PREV198529049025
Source: ORCID
Added: June 27, 2019
1985 conference paper
The isolated perfused porcine skin flap: A novel in vitro animal model system for drug and xenobiotic percutaneous absorption
Proceedings of the Fifth Annual Chemical Defense Bioscience Review. USAMRICD Report #SP 85-051, A911–926. Columbia, MD.
Source: NC State University Libraries
Added: August 6, 2018
1985 journal article
ULTRASTRUCTURE OF THE INTEGUMENT OF THE DOMESTIC PIG SUS-SCROFA FROM 1-14 WEEKS OF AGE
Anatomia Histologia Embryologia, 14(2), 97–115.
MeSH headings : Aging; Animals; Biopsy / veterinary; Epidermis / ultrastructure; Humans; Mast Cells / ultrastructure; Skin / ultrastructure; Swine / anatomy & histology
TL;DR:
The pig integument is morphologically similar to that of man and would serve as a useful animal model when age changes are accounted for and compared to the human integument.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
1984 journal article
ULTRASTRUCTURAL CHARACTERIZATION OF THE NASAL RESPIRATORY EPITHELIUM IN THE RAT
AMERICAN JOURNAL OF ANATOMY, 169(1), 31–43.
Contributors: N. Monteiroriviere * & J. Popp*
MeSH headings : Animals; Cilia / ultrastructure; Cytoplasm / ultrastructure; Endoplasmic Reticulum / ultrastructure; Epithelial Cells; Epithelium / ultrastructure; Male; Microscopy, Electron; Microvilli / ultrastructure; Nasal Mucosa / cytology; Nasal Mucosa / ultrastructure; Rats / anatomy & histology; Rats, Inbred F344 / anatomy & histology; Respiration
TL;DR:
The findings indicate the complexity of cell types composing the rat nasal respiratory epithelium, with goblet cells, basal cells, ciliated cells, nonciliated columnar cells, cuboidal cells, and brush cells having distinct ultrastructural features.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1984 journal article
Ultrastructural studies of the rat nasal mucosa
Activities (Chemical Industry Institute of Toxicology), 4, 1–4.
Source: NC State University Libraries
Added: August 6, 2018
1982 journal article
ULTRASTRUCTURAL STUDY OF SKIN INNERVATION OF THE DOMESTICATED PIG
Anatomical Record, 202(3), 132A. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BIOSIS&KeyUT=BIOSIS:PREV198324046718&KeyUID=BIOSIS:PREV198324046718
Source: ORCID
Added: June 27, 2019
1982 journal article
ULTRASTRUCTURE OF LANGERHANS CELLS IN THE DOMESTICATED PIG
Anatomical Record, 202(1), 161. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1982MZ03000064&KeyUID=WOS:A1982MZ03000064
Contributors: N. Monteiroriviere & M. Stromberg
Source: ORCID
Added: June 27, 2019
1981 journal article
INTERFOLLICULAR SMOOTH-MUSCLE IN THE SKIN OF THE DOMESTICATED PIG (SUS-SCROFA)
ANATOMICAL RECORD, 201(3), 455–462.
Contributors: M. Stromberg*, Y. Hwang* & N. Monteiroriviere*
MeSH headings : Animals; Female; Hair; Male; Models, Anatomic; Muscle, Smooth / anatomy & histology; Skin / anatomy & histology; Swine / anatomy & histology
TL;DR:
An interfollicular smooth muscle that spans the triad of hair follicles has been identified in the skin of the domesticated pig and it is postulated that upon contraction the muscle draws the base of the three aligned follicles together into a triangular conformation.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1981 journal article
LIGHT MICROSCOPIC MORPHOLOGY OF LOW RESISTANCE SKIN POINTS IN THE GUINEA-PIG
AMERICAN JOURNAL OF CHINESE MEDICINE, 9(2), 155–163.
Contributors: N. Monteiroriviere *, Y. Hwang* & M. Stromberg*
MeSH headings : Acupuncture Therapy; Animals; Cell Nucleus / ultrastructure; Female; Guinea Pigs; Hair / cytology; Male; Skin / cytology
TL;DR:
The epidermis at both LRSP and HRSP is indistinguishable at the light microscopic level, and finding of a Haarscheibe, an aggregation of Merkel cell-neurite complexes only at HRSP tends to preclude its role as an acupuncture neurotransducer.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1980 journal article
A QUALITATIVE AND QUANTITATIVE MICROSCOPIC STUDY OF LOW RESISTANCE SKIN POINTS OF THE GUINEA-PIG
Anatomical Record, 196(2), 269. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1980JR59000086&KeyUID=WOS:A1980JR59000086
Contributors: N. Monteiroriviere, Y. Hwang & M. Stromberg
Source: ORCID
Added: June 27, 2019
review
Biological properties of carbon nanotubes
Wei, W., Sethuraman, A., Jin, C., Monteiro-Riviere, N. A., & Narayan, R. J. [Review of ]. Journal of Nanoscience and Nanotechnology, 7(4-5), 1284–1297.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Epidermal cytotoxicity of topically-applied chemical mixtures in porcine skin
Monteiro-Riviere, N. A., Baynes, R., & Riviere, J. Journal of Veterinary Pharmacology and Therapeutics, 20(1997), 255–256.
Source: NC State University Libraries
Added: August 6, 2018
patent
Method and apparatus for determining a molecular descriptor of absorption for a candidate compound
Riviere, J. E., Xia, X. R., Baynes, R. E., & Monteiro-Riviere, N. A.
Source: NC State University Libraries
Added: August 6, 2018
report
Percutaneous absorption of chemical mixtures relevant to the Gulf War
Riviere, J. E., Monteiro-Riviere, N. A., & Baynes, R. E. In Technical report USAMRMC DAMD 17-99C-9047 (pp. 1–162).
Source: NC State University Libraries
Added: August 6, 2018
report
Percutaneous absorption of chemical mixtures relevant to the Gulf War
Riviere, J. E., Baynes, R. E., & Monteiro-Riviere, N. A. In USAMRMC, DAMD17-99C-9047. Technical Report ADB253401 (pp. 1–30).
Source: NC State University Libraries
Added: August 6, 2018
report
Percutaneous absorption of chemical mixtures relevant to the Gulf War. II.
Riviere, J. E., Baynes, R. E., & Monteiro-Riviere, N. A. In Technical report ADB, USAMRMC, DAMD17-99-C-9047 (pp. 1–34).
Source: NC State University Libraries
Added: August 6, 2018
report
Quantitating absorption of complex chemical mixtures
Riviere, J. E., Baynes, R. E., & Monteiro-Riviere, N. A. In Final report, CDC OH 007555 (pp. 1–27). Atlanta: Center for Disease Control.
Source: NC State University Libraries
Added: August 6, 2018
report
Quantitating the percutaneous absorption of mechanistically defined chemical mixtures
Riviere, J. E., Baynes, R. E., Smith, C. E., & Monteiro-Riviere, N. A. In NTIS report, AFOSR GF 49620-98-1-0105 (pp. 1–109).
Source: NC State University Libraries
Added: August 6, 2018
report
Quantitating the percutaneous absorption of mechanistically-defined chemical mixtures
Riviere, J. E., Montiero-Riviere, N. A., Baynes, R. E., Xia, X. R., & Smith, C. E. (Vol. 34, p. 1).
Source: NC State University Libraries
Added: August 6, 2018
Employment
Updated: January 14th, 2022 16:15
1984 - present
North Carolina State University Raleigh, NC, US
Professor Investigative Dermatology and Toxicology
clinical sciences
2012 - 2017
Kansas State University Manhattan, KS, US
Regents and University Distinguished Professor of Toxicology, Director of Nanotechnology Innovation Center of Kansas State
Nanotechnology Innovation Center of Kansas State, Dept. Anatomy and Physiology
Education
Updated: November 20th, 2015 17:09
1982 - 1984
Chemical Institute of Toxicology Research Triangle Park, North Carolina, US
Post-doctoral Fellow
Toxicology
1979 - 1981
Purdue University West Lafayette, IN, US
PhD
Anatomy
1976 - 1979
Purdue University West Lafayette, IN, US
MS
Anatomy
1972 - 1976
Stonehill College North Easton, MA, US
BS
Biology
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