Matthew Paul Donohue

Works (2)

Updated: July 5th, 2023 15:43

2017 article

Oligomeric Structure of Anabaena Sensory Rhodopsin in a Lipid Bilayer Environment by Combining Solid-State NMR and Long-range DEER Constraints

Milikisiyants, S., Wang, S., Munro, R. A., Donohue, M., Ward, M. E., Bolton, D., … Smirnov, A. I. (2017, May 10). Journal of Molecular Biology, Vol. 429, pp. 1903–1920.

By: S. Milikisiyants n, S. Wang *, R. Munro*, M. Donohue n, M. Ward *, D. Bolton*, L. Brown *, T. Smirnova n , V. Ladizhansky *, A. Smirnov n 

Contributors: S. Milikisiyants n, S. Wang *, R. Munro*, M. Donohue n, M. Ward *, D. Bolton*, L. Brown *, T. Smirnova n , V. Ladizhansky *, A. Smirnov n 

author keywords: double electron electron resonance (DEER); site-directed spin labeling; solid-state NMR; paramagnetic relaxation enhancement; membrane protein structure
MeSH headings : Anabaena / chemistry; Lipid Bilayers / chemistry; Magnetic Resonance Spectroscopy; Membrane Proteins / chemistry; Membrane Proteins / metabolism; Models, Biological; Models, Molecular; Protein Multimerization; Sensory Rhodopsins / chemistry; Sensory Rhodopsins / metabolism
topics (OpenAlex): Advanced NMR Techniques and Applications; Electron Spin Resonance Studies; Photoreceptor and optogenetics research
TL;DR: The combined approach of using complementary DEER and NMR measurements for the determination of oligomeric structures would be widely applicable to membrane proteins where paramagnetic tags can be introduced. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 article

The UDP-diacylglucosamine Pyrophosphohydrolase LpxH in Lipid A Biosynthesis Utilizes Mn2+ Cluster for Catalysis

Young, H. E., Donohue, M. P., Smirnova, T. I., Smirnov, A. I., & Zhou, P. (2013, July 30). Journal of Biological Chemistry, Vol. 288, pp. 26987–27001.

By: H. Young*, M. Donohue n, T. Smirnova n , A. Smirnov n  & P. Zhou *

Contributors: H. Young*, M. Donohue n, T. Smirnova n , A. Smirnov n  & P. Zhou *

MeSH headings : Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / isolation & purification; Bacterial Proteins / metabolism; Catalysis; Cloning, Molecular; Gene Expression; Haemophilus influenzae / enzymology; Haemophilus influenzae / genetics; Lipid A / biosynthesis; Lipid A / chemistry; Lipid A / metabolism; Manganese / chemistry; Manganese / metabolism; Pyrophosphatases / chemistry; Pyrophosphatases / genetics; Pyrophosphatases / isolation & purification; Pyrophosphatases / metabolism
topics (OpenAlex): ATP Synthase and ATPases Research; RNA and protein synthesis mechanisms; Enzyme Structure and Function
TL;DR: Overall, this work unambiguously establishes LpxH as a calcineurin-like phosphoesterase containing a Mn2+ cluster coordinated by conserved residues, which sets the scene for further structural investigation of the enzyme and for design of novel antibiotics targeting lipid A biosynthesis. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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