Works (2)
Updated: July 5th, 2023 15:43
2017 journal article
Oligomeric Structure of Anabaena Sensory Rhodopsin in a Lipid Bilayer Environment by Combining Solid-State NMR and Long-range DEER Constraints
JOURNAL OF MOLECULAR BIOLOGY, 429(12), 1903–1920.
Contributors: S. Milikisiyants n, S. Wang *, R. Munro*, n, M. Ward*, D. Bolton*, L. Brown *, T. Smirnova n , V. Ladizhansky *, A. Smirnov n
author keywords: double electron electron resonance (DEER); site-directed spin labeling; solid-state NMR; paramagnetic relaxation enhancement; membrane protein structure
MeSH headings : Anabaena / chemistry; Lipid Bilayers / chemistry; Magnetic Resonance Spectroscopy; Membrane Proteins / chemistry; Membrane Proteins / metabolism; Models, Biological; Models, Molecular; Protein Multimerization; Sensory Rhodopsins / chemistry; Sensory Rhodopsins / metabolism
TL;DR:
The combined approach of using complementary DEER and NMR measurements for the determination of oligomeric structures would be widely applicable to membrane proteins where paramagnetic tags can be introduced.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
The UDP-diacylglucosamine Pyrophosphohydrolase LpxH in Lipid A Biosynthesis Utilizes Mn2+ Cluster for Catalysis
JOURNAL OF BIOLOGICAL CHEMISTRY, 288(38), 26987–27001.
Contributors: H. Young*, n, T. Smirnova n , A. Smirnov n & P. Zhou *
MeSH headings : Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / isolation & purification; Bacterial Proteins / metabolism; Catalysis; Cloning, Molecular; Gene Expression; Haemophilus influenzae / enzymology; Haemophilus influenzae / genetics; Lipid A / biosynthesis; Lipid A / chemistry; Lipid A / metabolism; Manganese / chemistry; Manganese / metabolism; Pyrophosphatases / chemistry; Pyrophosphatases / genetics; Pyrophosphatases / isolation & purification; Pyrophosphatases / metabolism
TL;DR:
Overall, this work unambiguously establishes LpxH as a calcineurin-like phosphoesterase containing a Mn2+ cluster coordinated by conserved residues, which sets the scene for further structural investigation of the enzyme and for design of novel antibiotics targeting lipid A biosynthesis.
(via Semantic Scholar)
www.jbc.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
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