Works (2)
Updated: July 5th, 2023 15:48
2011 journal article
Studying Gene and Gene-Environment Effects of Uncommon and Common Variants on Continuous Traits: A Marker-Set Approach Using Gene-Trait Similarity Regression
AMERICAN JOURNAL OF HUMAN GENETICS, 89(2), 277–288.
MeSH headings : Chromosomes, Human, Pair 21 / genetics; Computer Simulation; Databases, Genetic; Environment; Genes / genetics; Genetic Markers; Humans; Models, Genetic; Mutation / genetics; Quantitative Trait, Heritable; Regression Analysis
TL;DR:
A similarity-based regression method for assessing the main genetic and interaction effects of a group of markers on quantitative traits and is an ideal tool for evaluating associations between phenotype and marker sets defined by linkage disequilibrium blocks, genes, or pathways in whole-genome analysis.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
A quality control algorithm for filtering SNPs in genome-wide association studies
BIOINFORMATICS, 26(14), 1731–1737.
MeSH headings : Algorithms; Genome; Genome-Wide Association Study / methods; Genome-Wide Association Study / standards; Polymorphism, Single Nucleotide; Quality Control
TL;DR:
An algorithm that is based on principal component analysis and clustering analysis to identify low-quality SNPs and suggests that with the same or fewer SNPs excluded, the proposed algorithm tends to give a similar or lower value of lambda, a reduced number of false associations, and retains all true associations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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