Works (26)
Updated: November 2nd, 2024 05:03
2024 journal article
Bovine Rhinitis B Virus Variant as the Putative Cause of Bronchitis in Goat Kids
VIRUSES-BASEL, 16(7).
author keywords: bronchitis; picornavirus; caprine; bovine rhinitis B virus; zoonotic; cross-species transmission; genetic diversity
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 1, 2024
2024 journal article
Characterization of neurologic disease-associated <i>Streptococcus suis</i> strains within the United States swine herd and use of diagnostic tools
Characterization of neurologic disease-associated Streptococcus suis. Journal of Clinical Microbiology.
Source: ORCID
Added: October 15, 2024
2024 journal article
Clinical characterization of a hypersensitivity mixed bacterial and fungal dermatitis in a translational model of porcine NASH
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 13.
author keywords: NASH; skin evaluation system; large animal model; microbiome; dermatitis
TL;DR:
The provision of a methionine- and choline-deficient, high fat diet represents an effective approach for inducing NASH liver disease in pigs but predisposes study animals to multiple side effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 7, 2024
2024 journal article
Diagnostic survey of analytical methods used to determine bone mineralization in pigs
Journal of Animal Science.
Source: ORCID
Added: April 8, 2024
2024 journal article
Effect of bone and analytical method on assessment of bone mineralization in response to dietary phosphorus, phytase, and vitamin D in finishing pigs
Journal of Animal Science.
Source: ORCID
Added: June 22, 2024
2024 journal article
Structure and Antigenicity of the Porcine Astrovirus 4 Capsid Spike
Viruses.
Source: ORCID
Added: October 15, 2024
2023 journal article
Detection and disease diagnosis trends (2017–2022) for Streptococcus suis, Glaesserella parasuis, Mycoplasma hyorhinis, Actinobacillus suis and Mycoplasma hyosynoviae at Iowa State University Veterinary Diagnostic Laboratory
BMC Veterinary Research.
TL;DR:
The high frequency of co-detection and -disease diagnosis with other infectious etiologies, such as PRRSV and IAV is highlighted, demonstrating that to minimize the health impact of these endemic bacterial agents it is imperative to establish effective viral control programs.
(via Semantic Scholar)
Source: ORCID
Added: January 24, 2024
2023 journal article
Porcine Astrovirus 4 Detection in Lesions of Epitheliotropic Viral Infection in the Porcine Respiratory Tract
Transboundary and Emerging Diseases, 2023, 1–4.
Ed(s): S. Zhai
TL;DR:
In this retrospective study of young pigs with clinical respiratory disease of unknown etiology, PoAstV4 was detected with RNA in situ hybridization in lesions consistent with epitheliotropic viral infection in 85 of 117 pigs, the first report associating an astrovirus with respiratory pathology
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: July 3, 2023
2023 journal article
The effect of bone and analytical methods on the assessment of bone mineralization response to dietary phosphorus, phytase, and vitamin D in nursery pigs
Journal of Animal Science.
TL;DR:
Differences in bone density and ash in response to P and vitamin D were most apparent with fibulas and 2nd ribs and there were apparent differences in the bone ash percentage between defatted and non-defatted bone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: January 24, 2024
2022 journal article
Bovine Coronavirus Infects the Respiratory Tract of Cattle Challenged Intranasally
Frontiers in Veterinary Science, 9.
TL;DR:
Data collected support that this BCoV challenge resulted in respiratory infections as evidenced by the isolation of B coV in BAL fluids and positive qPCR, immunohistochemistry (IHC), and histopathologic lesions in the upper and lower respiratory tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: July 3, 2023
2022 journal article
Bovine coronavirus in the lower respiratory tract of cattle with respiratory disease
Journal of Veterinary Diagnostic Investigation, 34(3), 482–488.
MeSH headings : Animals; Cattle; Cattle Diseases; Coronavirus Infections / veterinary; Coronavirus, Bovine; Respiratory System / pathology; Respiratory Tract Infections / veterinary
TL;DR:
A role of BCoV in respiratory tract infection and pathology is confirmed, and it is shown that the virus likely plays a role in the development of BRD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: June 8, 2023
2022 journal article
Congenital Limb Deformities in a Neonatal Crossbred Pig
Case Reports in Veterinary Medicine, 2022, 1–4.
Ed(s): N. Giadinis
TL;DR:
The pathology and imaging findings in two neonatal piglets with congenital limb deformities are described, including the first reported case of hindlimb meromelia with syndactyly in a pig.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: June 8, 2023
2021 journal article
<i>Streptococcus gallolyticus</i> and Bacterial Endocarditis in Swine, United States, 2015–2020
Emerging Infectious Diseases, 28(1), 192–195.
MeSH headings : Animals; Endocarditis / epidemiology; Endocarditis / veterinary; Endocarditis, Bacterial / epidemiology; Endocarditis, Bacterial / veterinary; Retrospective Studies; Streptococcal Infections / epidemiology; Streptococcal Infections / veterinary; Streptococcus gallolyticus; Swine; United States / epidemiology
TL;DR:
This emerging infection in swine could aid study of endocarditis in humans and could aid research into the causes of valvular endocardritis in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: July 3, 2023
2021 journal article
Disease diagnostic coding to facilitate evidence-based medicine: current and future perspectives
Journal of Veterinary Diagnostic Investigation, 33(3), 419–427.
MeSH headings : Animal Diseases / diagnosis; Animals; Clinical Coding / statistics & numerical data; Databases, Factual; Evidence-Based Medicine / instrumentation; Iowa; Laboratories / statistics & numerical data; Veterinary Medicine / instrumentation
TL;DR:
How a consistent, intuitive, and useful disease diagnosis coding system is being developed and utilized at the Iowa State University Veterinary Diagnostic Laboratory to facilitate evidence-based medicine and utilize diagnostic coding for continuous improvement of animal health and welfare is focused on.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: June 8, 2023
2021 journal article
Visualization and application of disease diagnosis codes for population health management using porcine diseases as a model
Journal of Veterinary Diagnostic Investigation, 33(3), 428–438.
MeSH headings : Animals; Clinical Coding / statistics & numerical data; Population Health Management; Sus scrofa; Swine; Swine Diseases / diagnosis; Veterinary Medicine / methods
TL;DR:
The semi-automatic standardized creation of a visualization platform allowed the transformation of diagnostic report data into aggregated information to visualize and monitor disease diagnosis and the approach taken to visualize trends of disease occurrence using porcine disease diagnostic code data for the period 2010 to 2019 is presented.
(via Semantic Scholar)
Source: ORCID
Added: June 8, 2023
2020 journal article
Comparative Sequence Analysis of Historic and Current Porcine Rotavirus C Strains and Their Pathogenesis in 3-Day-Old and 3-Week-Old Piglets
Frontiers in Microbiology, 11.
TL;DR:
It is confirmed that these current, genetically heterogeneous PRVC strains possess distinct pathobiological characteristics that may contribute to the increased prevalence of PRVC diarrhea in neonatal suckling piglets.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(OpenAlex)
Source: ORCID
Added: July 3, 2023
2020 journal article
Establishment and characterization of a porcine B cell lymphoma cell line
Experimental Cell Research, 390(2), 111986.
MeSH headings : Animals; Antigens, CD / genetics; Antigens, CD / immunology; Apoptosis; B-Lymphocytes / immunology; B-Lymphocytes / pathology; Biomarkers, Tumor / genetics; Biomarkers, Tumor / immunology; Cell Line, Tumor; Cell Lineage / genetics; Cell Lineage / immunology; Cell Movement; Cell Proliferation; Cell Separation / methods; Founder Effect; Gene Expression Profiling; Humans; Lymph Nodes / immunology; Lymph Nodes / pathology; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / immunology; Lymphoma, B-Cell / pathology; PAX5 Transcription Factor / genetics; PAX5 Transcription Factor / immunology; Proto-Oncogene Proteins c-bcl-6 / genetics; Proto-Oncogene Proteins c-bcl-6 / immunology; Spleen / immunology; Spleen / pathology; Swine; Transcriptome
TL;DR:
These new Porcine B cell lymphoma cell lines will be a valuable resource for more in-depth cellular investigations into the porcine immune system and cancer, as well as providing a potential tool for the growth of lymphotropic viruses of pigs and humans.
(via Semantic Scholar)
Source: ORCID
Added: July 3, 2023
2020 journal article
Extraskeletal chondrosarcoma in the tongue of a dog: case report and retrospective analysis of 236 tongue masses (2011–2019)
Journal of Veterinary Diagnostic Investigation, 32(3), 440–443.
MeSH headings : Animals; Chondrosarcoma / pathology; Chondrosarcoma / veterinary; Dog Diseases / pathology; Dogs; Male; Neoplasms, Connective and Soft Tissue / pathology; Neoplasms, Connective and Soft Tissue / veterinary; Retrospective Studies; Tongue Neoplasms / pathology; Tongue Neoplasms / veterinary
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: June 8, 2023
2020 journal article
The PRRSV-Specific Memory B Cell Response Is Long-Lived in Blood and Is Boosted During Live Virus Re-exposure
Frontiers in Immunology, 11.
MeSH headings : Animals; Antibodies, Neutralizing / blood; Antibodies, Viral / blood; B-Lymphocytes / immunology; Immunologic Memory / immunology; Porcine respiratory and reproductive syndrome virus / immunology; RNA, Viral / blood; Swine; Vaccination; Viral Nonstructural Proteins / immunology; Viral Vaccines / immunology
TL;DR:
The creation and validation of a PRRSV nsp7-specific B cell tetramer now facilitates the ability to detect very rare memory B cells and thus define the memory response of the pig and answers key questions involved in regional specialization of the immune response following intramuscular inoculation ofPRRSV MLV.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: July 3, 2023
2019 journal article
Bilateral Sterile Pyogranulomatous Keratitis in a Dog
Case Reports in Veterinary Medicine, 2019, 1–4.
TL;DR:
The first documented case of bilateral sterile pyogranulomatous keratitis absent of etiological organisms in a dog is described, in a 16-year-old spayed female rat terrier dog.
(via Semantic Scholar)
Source: ORCID
Added: July 3, 2023
2018 journal article
B Cell Tetramer Development for Veterinary Vaccinology
Viral Immunology, 31(1), 1–10.
MeSH headings : Animals; B-Lymphocyte Subsets / immunology; B-Lymphocyte Subsets / metabolism; Biotin / chemistry; Immunologic Memory / immunology; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / prevention & control; Porcine respiratory and reproductive syndrome virus / immunology; Protein Multimerization; Receptors, Antigen, B-Cell / immunology; Receptors, Antigen, B-Cell / metabolism; Receptors, Complement 3d / immunology; Receptors, Complement 3d / metabolism; Recombinant Proteins / chemistry; Recombinant Proteins / immunology; Sensitivity and Specificity; Spleen / cytology; Spleen / immunology; Swine; Vaccination / veterinary; Viral Nonstructural Proteins / chemistry; Viral Nonstructural Proteins / immunology
TL;DR:
This work created a B cell tetramer to porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural protein 7 (nsp7) to efficiently and effectively investigate the memory B cell response, a hallmark of anti-viral immunity.
(via Semantic Scholar)
Source: ORCID
Added: July 3, 2023
2018 journal article
Porcine reproductive and respiratory syndrome virus neutralizing antibodies provide in vivo cross-protection to PRRSV1 and PRRSV2 viral challenge
Virus Research, 248, 13–23.
MeSH headings : Animals; Antibodies, Neutralizing / immunology; Antibodies, Viral / immunology; Cross Protection / immunology; Genotype; Immunity, Humoral; Immunization, Passive; Immunoglobulin G / immunology; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / prevention & control; Porcine Reproductive and Respiratory Syndrome / virology; Porcine respiratory and reproductive syndrome virus / classification; Porcine respiratory and reproductive syndrome virus / genetics; Porcine respiratory and reproductive syndrome virus / immunology; Swine; Viral Proteins / immunology
TL;DR:
The results show that immunological approaches aimed at induction of broadly neutralizing antibodies may substantially enhance immune protection against PRRSV and that naturally occurring viral isolates are able to induce protective humoral immunity against unrelatedPRRSV challenge, thus removing a major conceptual barrier to vaccine development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: July 3, 2023
2017 journal article
Effector mechanisms of humoral immunity to porcine reproductive and respiratory syndrome virus
Veterinary Immunology and Immunopathology, 186, 15–18.
MeSH headings : Animals; Immunity, Humoral; Porcine respiratory and reproductive syndrome virus / immunology; Swine
TL;DR:
It is essential to understand the immunological significance of antibody functions, including recently described broadly neutralizing antibodies and potential non-neutralizing activities, in the immune response to PRRSV.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: July 3, 2023
2017 journal article
Interleukin-21 Drives Proliferation and Differentiation of Porcine Memory B Cells into Antibody Secreting Cells
PLOS ONE, 12(1), e0171171.
Ed(s): G. Renukaradhya
MeSH headings : Animals; Antibody-Producing Cells / cytology; Antibody-Producing Cells / immunology; B-Cell Activating Factor / pharmacology; B-Lymphocytes / cytology; B-Lymphocytes / immunology; Cell Differentiation / drug effects; Cell Proliferation / drug effects; Cell Survival / drug effects; Immunoglobulin G / metabolism; Immunoglobulin M / metabolism; Interleukins / pharmacology; Swine; Tumor Necrosis Factor Ligand Superfamily Member 13 / pharmacology
TL;DR:
The results highlight the IL-21-driven expansion and differentiation of memory B cells in vitro without stimulation of the surface immunoglobulin receptor complex, as well as the establishment of a defined memory B cell culture system for characterization of vaccine responses in outbred animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: July 3, 2023
2017 journal article
Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus
Viruses, 9(6), 148.
MeSH headings : Adaptive Immunity; Animals; Antibodies, Neutralizing; Antibodies, Viral / immunology; B-Lymphocytes / immunology; Humans; Immunity, Cellular; Immunity, Humoral; Immunologic Memory; Killer Cells, Natural / immunology; Mice; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / virology; Porcine respiratory and reproductive syndrome virus / immunology; Swine; T-Lymphocytes / immunology; Vaccines, Attenuated / administration & dosage; Vaccines, Attenuated / immunology; Viral Vaccines / administration & dosage; Viral Vaccines / immunology
TL;DR:
Current knowledge regarding cellular and humoral components of the adaptive immune response to PRRSV infection that mediate primary and memory immune protection against viruses are summarized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: July 3, 2023
2012 journal article
Inhibition of Cellular Autophagy Deranges Dengue Virion Maturation
Journal of Virology, 87(3), 1312–1321.
MeSH headings : Animals; Autophagy / drug effects; Cell Line; Dengue / pathology; Dengue / virology; Dengue Virus / growth & development; Dengue Virus / physiology; Disease Models, Animal; Female; Humans; Male; Mice; Virus Assembly; Virus Replication
TL;DR:
It is concluded that the presence of functional autophagy components facilitates viral RNA replication and, more importantly, is required for infectious dengue virus production.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: July 3, 2023
Employment
Updated: June 8th, 2023 09:36
2023 - present
North Carolina State University Raleigh, North Carolina, US
Assistant professor
Population Health and Pathobiology
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