Melissa R. Gaddy

Works (3)

Updated: July 5th, 2023 15:38

2019 journal article

Robust spatiotemporal fractionation schemes in the presence of patient setup uncertainty

MEDICAL PHYSICS, 46(7), 2988–3000.

By: M. Gaddy n, J. Unkelbach * & D. Papp n 

Contributors: M. Gaddy n, J. Unkelbach * & D. Papp n 

author keywords: optimization; optimization under uncertainty; spatiotemporal fractionation; treatment planning
MeSH headings : Dose Fractionation, Radiation; Humans; Liver Neoplasms / radiotherapy; Models, Statistical; Probability; Proton Therapy; Radiotherapy Planning, Computer-Assisted / methods; Stochastic Processes; Uncertainty
TL;DR: In the presence of patient setup uncertainty, spatiotemporally fractionated treatment plans exhibit the same robust tumor coverage as their uniformly fractionated counterparts and still retain the benefit in sparing healthy tissues. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 5, 2019

2018 journal article

Optimization of spatiotemporally fractionated radiotherapy treatments with bounds on the achievable benefit

PHYSICS IN MEDICINE AND BIOLOGY, 63(1).

By: M. Gaddy n, S. Yildiz *, J. Unkelbach * & D. Papp n 

author keywords: treatment planning; optimization; spatiotemporal fractionation
MeSH headings : Dose Fractionation, Radiation; Humans; Liver Neoplasms / radiotherapy; Organs at Risk / radiation effects; Radiotherapy Planning, Computer-Assisted / methods; Radiotherapy Planning, Computer-Assisted / standards; Radiotherapy, Intensity-Modulated / methods; Treatment Outcome
TL;DR: The results indicate that spatiotemporal treatments can achieve substantial reductions in normal tissue dose and BED, and that local optimization techniques provide high-quality plans that are close to realizing the maximum potentialnormal tissue dose reduction. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Technical Note: Improving the VMERGE treatment planning algorithm for rotational radiotherapy

MEDICAL PHYSICS, 43(7), 4093–4097.

By: M. Gaddy n & D. Papp n 

Contributors: M. Gaddy n & D. Papp n 

author keywords: arc therapy; treatment planning; optimization; rotational therapy
MeSH headings : Algorithms; Humans; Male; Prostatic Neoplasms / radiotherapy; Radiotherapy Planning, Computer-Assisted / methods; Radiotherapy, Intensity-Modulated / methods; Spinal Cord Neoplasms / radiotherapy; Time Factors
TL;DR: In the authors' computational study they found that both proposed modifications, especially the regularization, yield noticeably improved treatment plans for the same treatment times than what can be obtained using the original VMERGE method. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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