Matthew Ryan Keogh

Works (2)

Updated: July 5th, 2023 15:50

2010 journal article

Three nicotine demethylase genes mediate nornicotine biosynthesis in Nicotiana tabacum L Functional characterization of the CYP82E10 gene

PHYTOCHEMISTRY, 71(17-18), 1988–1998.

By: R. Lewis n, S. Bowen n, M. Keogh n & R. Dewey n

author keywords: Nicotiana tabacum; Solanaceae; Gene function; Alkaloids; Nornicotine; Tobacco specific nitrosamine (TSNA); Cytochrome P450; CYP82E10
MeSH headings : Carcinogens / chemistry; Carcinogens / pharmacology; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Molecular Structure; Nicotine / analogs & derivatives; Nicotine / biosynthesis; Nicotine / chemistry; Nicotine / genetics; Nicotine / metabolism; Nitrosamines / chemistry; Nitrosamines / pharmacology; Plant Leaves / chemistry; Plant Leaves / genetics; Plant Leaves / metabolism; Plant Proteins / genetics; Plant Proteins / metabolism; Tobacco / chemistry; Tobacco / enzymology; Tobacco / genetics
TL;DR: The introduction of knockout mutations in all three tobacco NND genes into commercial breeding lines promises to be a viable strategy for reducing the levels of one of the best characterized animal carcinogens found in tobacco products. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Functional Characterization of Phospholipid N-Methyltransferases from Arabidopsis and Soybean

JOURNAL OF BIOLOGICAL CHEMISTRY, 284(23), 15439–15447.

By: M. Keogh n, P. Courtney n, A. Kinney* & R. Dewey n

MeSH headings : Arabidopsis / enzymology; Arabidopsis / genetics; Arabidopsis Proteins / metabolism; Cloning, Molecular; DNA Primers; DNA, Complementary / genetics; DNA, Plant / genetics; Kinetics; Mutagenesis, Insertional; Phosphatidylcholines / biosynthesis; Phosphatidylethanolamine N-Methyltransferase / genetics; Phosphatidylethanolamine N-Methyltransferase / metabolism; Plant Proteins / metabolism; Polymerase Chain Reaction; Recombinant Proteins / metabolism; Saccharomyces cerevisiae / enzymology; Soybeans / enzymology; Soybeans / genetics
TL;DR: Using a heterologous yeast expression system, it was shown that plant PLMTs methylate phosphatidylmonomethylethanolamine and phosphatidyldimethyleanolamine but cannot utilize phosphatido-phosphate as a substrate, suggesting the degree with which PtdCho synthesis is dependent upon PLMT activities will also vary widely throughout the plant kingdom. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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