Matthew Ryan Keogh

Works (2)

Updated: July 5th, 2023 15:50

2010 article

Three nicotine demethylase genes mediate nornicotine biosynthesis in Nicotiana tabacum L.: Functional characterization of the CYP82E10 gene

Lewis, R. S., Bowen, S. W., Keogh, M. R., & Dewey, R. E. (2010, October 26). Phytochemistry, Vol. 10, pp. 1988–1998.

By: R. Lewis n , S. Bowen n, M. Keogh n & R. Dewey n 

author keywords: Nicotiana tabacum; Solanaceae; Gene function; Alkaloids; Nornicotine; Tobacco specific nitrosamine (TSNA); Cytochrome P450; CYP82E10
MeSH headings : Carcinogens / chemistry; Carcinogens / pharmacology; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Molecular Structure; Nicotine / analogs & derivatives; Nicotine / biosynthesis; Nicotine / chemistry; Nicotine / genetics; Nicotine / metabolism; Nitrosamines / chemistry; Nitrosamines / pharmacology; Plant Leaves / chemistry; Plant Leaves / genetics; Plant Leaves / metabolism; Plant Proteins / genetics; Plant Proteins / metabolism; Tobacco / chemistry; Tobacco / enzymology; Tobacco / genetics
topics (OpenAlex): Plant Genetic and Mutation Studies; Plant-Microbe Interactions and Immunity; Plant tissue culture and regeneration
TL;DR: The introduction of knockout mutations in all three tobacco NND genes into commercial breeding lines promises to be a viable strategy for reducing the levels of one of the best characterized animal carcinogens found in tobacco products. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2009 article

Functional Characterization of Phospholipid N-Methyltransferases from Arabidopsis and Soybean

Keogh, M. R., Courtney, P. D., Kinney, A. J., & Dewey, R. E. (2009, April 15). Journal of Biological Chemistry, Vol. 4.

By: M. Keogh*, P. Courtney n, A. Kinney* & R. Dewey n 

MeSH headings : Arabidopsis / enzymology; Arabidopsis / genetics; Arabidopsis Proteins / metabolism; Cloning, Molecular; DNA Primers; DNA, Complementary / genetics; DNA, Plant / genetics; Kinetics; Mutagenesis, Insertional; Phosphatidylcholines / biosynthesis; Phosphatidylethanolamine N-Methyltransferase / genetics; Phosphatidylethanolamine N-Methyltransferase / metabolism; Plant Proteins / metabolism; Polymerase Chain Reaction; Recombinant Proteins / metabolism; Saccharomyces cerevisiae / enzymology; Soybeans / enzymology; Soybeans / genetics
topics (OpenAlex): Lipid metabolism and biosynthesis; Peroxisome Proliferator-Activated Receptors; RNA modifications and cancer
TL;DR: Using a heterologous yeast expression system, it was shown that plant PLMTs methylate phosphatidylmonomethylethanolamine and phosphatidyldimethyleanolamine but cannot utilize phosphatido-phosphate as a substrate, suggesting the degree with which PtdCho synthesis is dependent upon PLMT activities will also vary widely throughout the plant kingdom. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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