Michael Robert McLaren

https://orcid.org/0000-0003-1575-473X

microbiome, evolutionary theory, population genetics, microbial ecology, metagenomics, adaptation

Works (14)

Updated: July 5th, 2023 21:22
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2022 article

Implications of taxonomic bias for microbial differential-abundance analysis

McLaren, M. R., Nearing, J. T., Willis, A. D., Lloyd, K. G., & Callahan, B. J. (2022, August 19).

By: M. McLaren* , J. Nearing *, A. Willis *, K. Lloyd * & B. Callahan n 

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
Source: ORCID
Added: August 24, 2022

2021 journal article

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

NATURE COMMUNICATIONS, 12(1).

By: J. Fletcher n, C. Pike n, R. Parsons n, A. Rivera n, M. Foley n, M. McLaren n , S. Montgomery *, C. Theriot n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacterial Toxins / genetics; Bacterial Toxins / immunology; Bacterial Toxins / metabolism; Bacteroides / drug effects; Bacteroides / metabolism; Clostridioides difficile / genetics; Clostridioides difficile / immunology; Clostridioides difficile / metabolism; Clostridium Infections / immunology; Clostridium Infections / microbiology; Clostridium Infections / pathology; Disease Models, Animal; Extracellular Matrix / metabolism; Female; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / immunology; Gene Expression Regulation, Bacterial / immunology; Host-Pathogen Interactions / genetics; Host-Pathogen Interactions / immunology; Humans; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Male; Matrix Metalloproteinases / metabolism; Mice; Nutrients / metabolism; Proteolysis; RNA, Bacterial / genetics; RNA, Bacterial / isolation & purification; RNA-Seq; Sigma Factor / genetics; Sigma Factor / immunology; Sigma Factor / metabolism; Transcriptome / immunology
Sources: ORCID, Web Of Science
Added: January 20, 2021

2021 review

Evaluating Use Cases for Human Challenge Trials in Accelerating SARS-CoV-2 Vaccine Development

[Review of ]. CLINICAL INFECTIOUS DISEASES, 72(4), 710–715.

By: L. Nguyen *, C. Bakerlee *, T. McKelvey *, S. Rose*, A. Norman, N. Joseph*, D. Manheim *, M. McLaren n  ...

co-author countries: Canada 🇨🇦 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Israel 🇮🇱 United States of America 🇺🇸
author keywords: vaccine evaluation; COVID-19; pandemic; controlled human infection; human challenge trial
MeSH headings : COVID-19; COVID-19 Vaccines; Clinical Trials as Topic; Humans; Pandemics; SARS-CoV-2
Sources: Web Of Science, ORCID
Added: June 10, 2021

2020 journal article

Clostridioides difficile carriage in animals and the associated changes in the host fecal microbiota

ANAEROBE, 66.

By: R. Thanissery n, M. McLaren n , A. Rivera n, A. Reed n, N. Betrapally n, T. Burdette n, J. Winston n, M. Jacob n, B. Callahan n , C. Theriot n

co-author countries: United States of America 🇺🇸
author keywords: C. difficile; C. hiranonis; Microbiome; Ribotype; Antibiotic resistance; Animal; Canine; Equine; Feline
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacterial Toxins / genetics; Bacterial Toxins / metabolism; Bacterial Typing Techniques; Cats; Chlorocebus aethiops; Clostridioides difficile / classification; Clostridioides difficile / drug effects; Clostridioides difficile / physiology; Clostridium Infections / epidemiology; Clostridium Infections / microbiology; Clostridium Infections / veterinary; Coculture Techniques; Dogs; Feces / microbiology; Female; Gastrointestinal Microbiome; Horses; Hospitals, Animal; Host-Pathogen Interactions; Male; Microbial Interactions; Microbial Sensitivity Tests; North Carolina; Polymerase Chain Reaction; Prevalence; RNA, Ribosomal, 16S; Ribotyping; Risk Factors; Tertiary Healthcare; Vero Cells
Sources: Web Of Science, ORCID
Added: January 11, 2021

2020 journal article

Pathogen resistance may be the principal evolutionary advantage provided by the microbiome

Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1808), 20190592.

By: M. McLaren n  & B. Callahan n 

co-author countries: United States of America 🇺🇸
author keywords: colonization resistance; commensal bacteria; defensive symbionts; evolution of immunity; host-microbiome interactions; microbiome
MeSH headings : Animals; Biological Evolution; Disease Resistance; Host Microbial Interactions; Invertebrates / microbiology; Plant Diseases; Plants / microbiology; Symbiosis; Vertebrates / microbiology
Source: ORCID
Added: August 12, 2020

2020 journal article

Understanding and interpreting community sequencing measurements of the vaginal microbiome

BJOG: An International Journal of Obstetrics & Gynaecology, 127(2), 139–146.

By: H. Berman  n, . McLaren  n & B. Callahan n 

co-author countries: United States of America 🇺🇸
author keywords: 16S rRNA gene; amplicon sequencing; metagenomics; metatranscriptomics; vaginal microbiome
MeSH headings : Female; Humans; Microbiota / genetics; RNA, Ribosomal, 16S; Reproducibility of Results; Sequence Analysis, DNA; Vagina / microbiology
Source: ORCID
Added: November 2, 2019

2019 article

Characterization of C. difficile strains isolated from companion animals and the associated changes in the host fecal microbiota

Thanissery, R., McLaren, M., Rivera, A., Reed, A. D., Betrapally, N., Burdette, T., … Theriot, C. (2019, October).

By: R. Thanissery n, M. McLaren n , A. Rivera n, A. Reed n, N. Betrapally n, T. Burdette n, J. Winston  n, M. Jacob  n, B. Callahan  n, C. Theriot  n

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: December 9, 2019

2019 journal article

Consistent and correctable bias in metagenomic sequencing experiments

ELife.

By: M. McLaren n , A. Willis * & B. Callahan n 

co-author countries: United States of America 🇺🇸
MeSH headings : Bacteria / classification; Bacteria / genetics; Bias; Biota; Cluster Analysis; DNA, Ribosomal / chemistry; DNA, Ribosomal / genetics; Metagenomics / methods; Models, Theoretical; Phylogeny; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA / methods
Source: ORCID
Added: September 10, 2019

2019 journal article

Consistent and correctable bias in metagenomic sequencing measurements

BioRxiv, 2, 559831.

By: M. McLaren n , A. Willis * & B. Callahan n 

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: February 26, 2019

2019 journal article

Current State of and Future Opportunities for Prediction in Microbiome Research: Report from the Mid-Atlantic Microbiome Meet-up in Baltimore on 9 January 2019.

MSystems, 10.

By: E. Sakowski *, G. Uritskiy*, R. Cooper*, M. Gomes *, . McLaren  n, J. Meisel*, R. Mickol *, C. Mintz* ...

co-author countries: United States of America 🇺🇸
author keywords: microbiome; bioinformatics; metagenomics; prediction; machine learning; conceptual models; quantitative models
Source: ORCID
Added: December 9, 2019

2018 article

In Nature, There Is Only Diversity

MBIO, Vol. 9.

By: M. McLaren n  & B. Callahan n 

co-author countries: United States of America 🇺🇸
author keywords: metagenomics; microbial ecology; microbiome
MeSH headings : Metagenomics; RNA, Ribosomal, 16S
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Fitness-valley crossing in subdivided asexual populations

BioRxiv.

By: M. McLaren* 

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: February 11, 2019

2013 journal article

The Atacama Cosmology Telescope: Cosmological parameters from three seasons of data

Journal of Cosmology and Astroparticle Physics, 2013(10).

Contributors: J. Sievers *, R. Hlozek *, M. Nolta*, V. Acquaviva *, G. Addison *, P. Ade *, P. Aguirre *, M. Amiri * ...

author keywords: CMBR experiments; Sunyaev-Zeldovich effect; physics of the early universe; cosmological parameters from CMBR
Source: ORCID
Added: February 11, 2019

2011 journal article

The Atacama cosmology telescope: Detection of Sunyaev-Zel'dovich decrement in groups and clusters associated with luminous red galaxies

Astrophysical Journal, 736(1).

By: N. Hand *, J. Appel *, N. Battaglia *, J. Richard Bond, S. Das*, M. Devlin *, J. Dunkley*, R. Dünner * ...

co-author countries: Canada 🇨🇦 Chile 🇨🇱 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Japan 🇯🇵 Taiwan, Province of China 🇹🇼 United States of America 🇺🇸 South Africa 🇿🇦

Contributors: N. Hand *, J. Appel *, N. Battaglia *, J. Richard Bond, S. Das*, M. Devlin *, J. Dunkley*, R. Dünner * ...

author keywords: cosmic background radiation; cosmology: observations; galaxies: clusters: general
Source: ORCID
Added: February 11, 2019

Employment

Updated: March 15th, 2022 21:14

2022 - present

Massachusetts Institute of Technology Cambridge, Massachusetts, US
Research Scientist Media Lab

2017 - 2022

North Carolina State University Raleigh, North Carolina, US
Postdoc Population Health and Pathobiology

Education

Updated: November 15th, 2016 20:49

2010 - 2016

Stanford University Stanford, CA, US
PhD Biology

2005 - 2009

University of Pennsylvania Philadelphia, PA, US
BA Mathematics