Marcelo Rodriguez-Puebla

Works (18)

Updated: April 5th, 2024 02:44

2022 article

Cyclin-dependent kinase 4 expression alters the number of keratinocyte stem cells in the mouse hair follicle

Kim, S. H., Rodriguez, L. R. L., Macias, E., & Rodriguez-Puebla, M. L. (2022, February 3). CELL BIOLOGY INTERNATIONAL.

By: S. Kim n, L. Rodriguez*, E. Macias * & M. Rodriguez-Puebla n

author keywords: cell-cycle; epidermis; keratinocytes; skin; stem
MeSH headings : Animals; Cyclin-Dependent Kinase 4 / metabolism; Hair Follicle / metabolism; Keratinocytes; Mice; Stem Cells
TL;DR: It is reported that stem cells located in the bulge region of the HF (BuSCs) express high levels of cyclin‐dependent kinase 4 (CDK4) through the quiescent phase of the hair cycle, and deregulation of CDK4 protein levels contributes to distorting the self‐renewal/proliferation balance and, in turn, altering the number of BuSCs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 14, 2022

2021 journal article

CDK4 has the ability to regulate Aurora B and Cenpp expression in mouse keratinocytes

ONCOLOGY LETTERS, 22(4).

By: S. Lee n, L. Rodriguez*, R. Majumdar n, P. De Marval* & M. Rodriguez-Puebla n

author keywords: cell-cycle; cyclin-dependent kinase 4; Aurora-B; Centromere Protein P; skin; keratinocytes
TL;DR: The finding that Aurkb may have a crucial role in chromosome bi-orientation and the spindle assembly checkpoint, and that CENP-P could be required for proper kinetochore function suggests that dysregulation of CDK4 expression induces chromosomal instability and, in some cases, cancer development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 30, 2021

2020 article

Emergent functions of cyclin-dependent kinase 4 regulating aurora b and cenpp transcription

Lee, S. H., Rodriguez, L. R., Marval, P. L. M., & Rodriguez-Puebla, M. L. (2020, August). CANCER RESEARCH, Vol. 80.

By: S. Lee n, L. Rodriguez*, P. Marval & M. Rodriguez-Puebla n

Source: Web Of Science
Added: March 8, 2021

2017 journal article

Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation

ONCOLOGY LETTERS, 14(3), 2723–2734.

By: S. Lee n, X. Wang *, S. Kim*, Y. Kim * & M. Rodriguez-Puebla n

author keywords: skin; epidermis; papillomas; cyclin D3; cyclin-dependent kinase 6; cell cycle
TL;DR: It is demonstrated that cyclin D3 ablation does not affect keratinocyte proliferation, but instead increases apoptosis levels in the bulge region of the hair follicle, which reduces skin papilloma development in a Ras-dependent carcinogenesis model and suggests alterations in cell survival are a crucial mechanism for crippling cellular defense against neoplasia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Skp2 Deficiency Inhibits Chemical Skin Tumorigenesis Independent of p27(Kip1) Accumulation

AMERICAN JOURNAL OF PATHOLOGY, 182(5), 1854–1864.

By: C. Sistrunk  n, S. Kim n, X. Wang  n, S. Lee  n, Y. Kim *, E. Macias *, M. Rodriguez-Puebla n

MeSH headings : Animals; Apoptosis; Carcinogenesis / metabolism; Carcinogenesis / pathology; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Epidermis / metabolism; Epidermis / pathology; Gene Deletion; Humans; Kinetics; Mice; Mice, Inbred C57BL; Papilloma / metabolism; Papilloma / pathology; S-Phase Kinase-Associated Proteins / metabolism; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tumor Suppressor Protein p53 / deficiency; Tumor Suppressor Protein p53 / metabolism
TL;DR: It is concluded that p27(Kip1) accumulation is responsible for the hypoplasia observed in normal tissues of Skp2(-/-) mice but does not have a preponderant function in reducing skin tumorigenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development

CELL CYCLE, 11(2), 335–342.

By: X. Wang n, C. Sistrunk  n, P. Marval*, Y. Kim* & M. Rodriguez-Puebla n

author keywords: cell cycle; D-type cyclins; skin; carcinogenesis; epidermis
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell / chemically induced; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin D1 / genetics; Cyclin D1 / metabolism; Cyclin D2 / metabolism; Cyclin D3 / genetics; Cyclin D3 / metabolism; Gene Expression Regulation; Mice; Mice, Transgenic; Oncogene Protein p21(ras) / genetics; Papilloma / chemically induced; Papilloma / metabolism; Papilloma / pathology; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tumor Burden
TL;DR: Modulation of the levels of particular members of the D-type cyclin family could be useful to inhibit tumor development and, in particular, ras-mediated tumorigenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Skp2 Is Necessary for Myc-Induced Keratinocyte Proliferation but Dispensable for Myc Oncogenic Activity in the Oral Epithelium

AMERICAN JOURNAL OF PATHOLOGY, 178(6), 2470–2477.

By: C. Sistrunk  n, E. Macias *, K. Nakayama *, Y. Kim n & M. Rodriguez-Puebla n

MeSH headings : Animals; Cell Cycle Proteins / metabolism; Cell Proliferation; Epidermis / metabolism; Epidermis / pathology; Epithelium / metabolism; Epithelium / pathology; Keratinocytes / metabolism; Keratinocytes / pathology; Mice; Mice, Transgenic; Mouth / pathology; Mouth Neoplasms / metabolism; Mouth Neoplasms / pathology; Phenotype; Precancerous Conditions / pathology; Proto-Oncogene Proteins c-myc / metabolism; S-Phase Kinase-Associated Proteins / metabolism
TL;DR: It is suggested that Skp2 and p27(Kip1) are critical for Myc-driven keratinocyte proliferation; however, MyC-mediated tumorigenesis in the oral epithelium is independent of the Skp 2-p27( Kip 1) axis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Unexpected Reduction of Skin Tumorigenesis on Expression of Cyclin-Dependent Kinase 6 in Mouse Epidermis

AMERICAN JOURNAL OF PATHOLOGY, 178(1), 345–354.

By: X. Wang  n, C. Sistrunk  n & M. Rodriguez-Puebla n

MeSH headings : Animals; Cell Proliferation; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Cyclin-Dependent Kinase 4 / biosynthesis; Cyclin-Dependent Kinase 4 / genetics; Cyclin-Dependent Kinase 6 / biosynthesis; Cyclin-Dependent Kinase 6 / genetics; Epidermis / enzymology; Epidermis / pathology; Hyperplasia / enzymology; Keratin-5 / genetics; Keratinocytes / enzymology; Keratinocytes / pathology; Mice; Mice, Transgenic; Promoter Regions, Genetic; Skin Neoplasms / enzymology; Skin Neoplasms / genetics; Skin Neoplasms / metabolism
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Suppression of COX-2, IL-1 beta and TNF-alpha expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L.

FITOTERAPIA, 82(3), 414–421.

By: E. Mengoni*, G. Vichera*, L. Rigano*, M. Rodriguez-Puebla n, S. Galliano*, E. Cafferata *, O. Pivetta*, S. Moreno*, A. Vojnov *

author keywords: Skin inflammation; Carnosic acid; Carnosol; Cyclooxygenase; Interleukin; Tumor necrosis factor
MeSH headings : Abietanes / pharmacology; Abietanes / therapeutic use; Animals; Cyclooxygenase 2 Inhibitors / pharmacology; Cyclooxygenase 2 Inhibitors / therapeutic use; Dose-Response Relationship, Drug; Fibronectins / genetics; Fibronectins / metabolism; Gene Expression; Inflammation / chemically induced; Inflammation / drug therapy; Inflammation / metabolism; Intercellular Adhesion Molecule-1 / genetics; Intercellular Adhesion Molecule-1 / metabolism; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; Macrophages / drug effects; Macrophages / metabolism; Male; Mice; Mice, Inbred BALB C; Neutrophil Infiltration / drug effects; Nitric Oxide / biosynthesis; Phytotherapy; Plant Extracts / pharmacology; Plant Extracts / therapeutic use; Reverse Transcriptase Polymerase Chain Reaction; Rosmarinus / chemistry; Skin / drug effects; Skin / metabolism; Skin / pathology; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
TL;DR: It is shown for the first time in vivo that CA and CS differentially regulate the expression of inflammation-associated genes, thus demonstrating the pharmacological basis for the anti-inflammatory properties reported for CA andCS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development

AMERICAN JOURNAL OF PATHOLOGY, 173(2), 526–535.

By: E. Macias n, P. Marval*, A. De Siervi *, C. Conti *, A. Senderowicz* & M. Rodriguez-Puebla n

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Proliferation; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Cyclin-Dependent Kinase 2 / genetics; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Enzyme Activation; Epidermis / enzymology; Epidermis / pathology; Keratinocytes / enzymology; Keratinocytes / pathology; Mice; Mice, Transgenic; Mutation; Skin Neoplasms / chemically induced; Skin Neoplasms / enzymology; Skin Neoplasms / pathology
TL;DR: Although the indirect activation of CDK2 is sufficient to induce keratinocyte hyperproliferation, activation ofCDK2 alone does not induce malignant progression in Ras-mediated tumorigenesis, and Surprisingly, it is found that neither CDK 2 overexpression nor the indirectactivation of CDk2 enhanced skin tumor development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Enhanced Skin Carcinogenesis and Lack of Thymus Hyperplasia in Transgenic Mice Expressing Human Cyclin D1b (CCND1b)

MOLECULAR CARCINOGENESIS, 48(6), 508–516.

By: P. Rojas *, F. Benavides *, J. Blando *, C. Perez*, K. Cardenas*, E. Richie *, E. Knudsen *, D. Johnson * ...

author keywords: cyclin D1; skin carcinogenesis; DMBA; TPA; transgenic mouse model
MeSH headings : Animals; Base Sequence; Cell Transformation, Neoplastic / genetics; Cyclin D1 / genetics; DNA Primers; Exons; Hyperplasia; Introns; Mice; Mice, Transgenic; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Skin Neoplasms / genetics; Thymus Gland / pathology
TL;DR: Results show that human cyclin D1b has different biological functions than cyclinD1a and confirm its oncogenic properties. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis

CANCER RESEARCH, 68(1), 162–171.

By: E. Macias n, P. Marva*, A. Senderowicz*, J. Cullen n & M. Rodriguez-Puebla n

MeSH headings : Animals; Cell Count; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cyclin-Dependent Kinase 2 / analysis; Cyclin-Dependent Kinase 2 / genetics; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase 4 / analysis; Cyclin-Dependent Kinase 4 / genetics; Cyclin-Dependent Kinase 4 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / genetics; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Humans; Mice; Mice, Transgenic; Mouth / embryology; Mouth / enzymology; Pituitary Gland / enzymology; Pituitary Neoplasms / enzymology; Pituitary Neoplasms / genetics; Promoter Regions, Genetic; Stem Cells
TL;DR: It is shown that deregulation of CDK expression in the primitive oral epithelium plays a unique function, providing a selective advantage that gives rise to transgene-positive TA-like pituitary cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Robe of Cyclin D1 as a Mediator of c-Met- and beta-Catenin-Induced Hepatocarcinogenesis

CANCER RESEARCH, 69(1), 253–261.

By: M. Patil, S. Lee, E. Macias n, E. Lam, C. Xu *, K. Jones *, C. Ho, M. Rodriguez-Puebla n, X. Chen*

MeSH headings : Animals; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cyclin D1 / biosynthesis; Cyclin D1 / genetics; Cyclin D2; Cyclins / biosynthesis; Cyclins / genetics; Disease Models, Animal; Female; Humans; Liver Neoplasms, Experimental / genetics; Liver Neoplasms, Experimental / metabolism; Male; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-met / biosynthesis; Proto-Oncogene Proteins c-met / genetics; Transfection; Up-Regulation; beta Catenin / biosynthesis; beta Catenin / genetics
TL;DR: The results suggest that CCND1 functions as a mediator of beta-catenin during HCC pathogenesis, although other molecules may be required to fully propagate beta-Catenin signaling. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis

CANCER RESEARCH, 67(20), 9713–9720.

By: E. Macias n, Y. Kim n, P. Marval*, A. Klein-Szanto * & M. Rodriguez-Puebla n

MeSH headings : Animals; Carcinogens; Carcinoma, Squamous Cell / enzymology; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Cyclin-Dependent Kinase 2 / deficiency; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase 4 / metabolism; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Disease Progression; Enzyme Activation; Female; Male; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-myc / biosynthesis; Proto-Oncogene Proteins c-myc / genetics; Proto-Oncogene Proteins c-myc / metabolism; Skin Neoplasms / chemically induced; Skin Neoplasms / enzymology; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate; ras Proteins / metabolism
TL;DR: Overall, it is established that ras-induced tumors are more susceptible to CDK2 ablation than myc-induced tumorigenesis, suggesting that the efficacy of targetingCDK2 in tumor development and malignant progression is dependent on the oncogenic pathway involved. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Cyclin D2 and cyclin D3 play opposite roles in mouse skin carcinogenesis

Oncogene, 26(12), 1723–1730.

By: P. Rojas *, M. Cadenas*, P. Lin, F. Benavides, C. Conti & M. Rodriguez-Puebla*

MeSH headings : Animals; Carcinoma, Squamous Cell / physiopathology; Cell Transformation, Neoplastic; Cyclin D2; Cyclin D3; Cyclins / physiology; Immunoprecipitation; Mice; Mice, Transgenic; Skin Neoplasms / physiopathology
TL;DR: It is concluded that cyclin D3 and cycl in D-type cyclins play opposite roles in mouse skin tumor development and that the suppressive activity of cyclinD3 is associated with Cyclin D2 downregulation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27(Kip1)

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(11), 4122–4127.

By: W. Chien *, S. Rabin*, E. Macias  n, P. Marval*, K. Garrison*, J. Orthel*, M. Rodriguez-Puebla n, M. Fero *

author keywords: cell cycle; cyclin-dependent kinase inhibitor; growth genetics; pituitary tumor; thymus development
MeSH headings : Animals; Base Sequence; Cyclin-Dependent Kinase Inhibitor p27 / genetics; Cyclin-Dependent Kinase Inhibitor p27 / physiology; DNA / genetics; Female; Hyperplasia; Male; Mice; Mice, Knockout; Mice, Transgenic; Mosaicism; Mutation; Pituitary Gland / metabolism; Pituitary Neoplasms / etiology; Pituitary Neoplasms / genetics; Pituitary Neoplasms / pathology; Radiation Chimera; Spleen / pathology; Thymus Gland / pathology
TL;DR: The results indicate that the suppression of pars intermedia pituitary tumors by p27(Kip1) is cell-autonomous and does not contribute to overgrowth or infertility phenotypes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Enhanced malignant tumorigenesis in Cdk4 transgenic mice

ONCOGENE, 23(10), 1863–1873.

By: P. Marval n, E. Macias n, C. Conti * & M. Rodriguez-Puebla n

author keywords: CDK4; carcinogenesis; skin; cell-cycle; cyclin; papillomas
MeSH headings : Animals; Carcinoma / genetics; Carcinoma / pathology; Carcinoma, Squamous Cell / genetics; Carcinoma, Squamous Cell / pathology; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases / genetics; Humans; Mice; Mice, Transgenic; Papilloma / genetics; Papilloma / pathology; Proto-Oncogene Proteins; Skin Neoplasms / genetics; Skin Neoplasms / pathology
TL;DR: The results indicate that, contrary to the general assumption, the catalytic subunit,CDK4, has higher oncogenic activity than cyclin D1, revealing a potential use of CDK4 as therapeutic target. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation

AMERICAN JOURNAL OF PATHOLOGY, 161(2), 405–411.

By: M. Rodriguez-Puebla n, P. Marval*, M. LaCava*, D. Moons*, H. Kiyokawa * & C. Conti *

MeSH headings : Animals; Carcinogens / toxicity; Cell Division / genetics; Cell Transformation, Neoplastic / genetics; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases / deficiency; Cyclin-Dependent Kinases / genetics; Keratinocytes / cytology; Keratinocytes / enzymology; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins; Skin Neoplasms / enzymology; Skin Neoplasms / etiology; Skin Neoplasms / genetics; Tetradecanoylphorbol Acetate / toxicity
TL;DR: The results suggest that therapeutic approaches to inhibit cdk4 activity could provide a target to inhibit tumor development with minimal or no effect in normal tissue. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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