Maura Brown

Works (4)

Updated: July 5th, 2023 14:23

2022 journal article

Intranasal Delivery of Thermostable Subunit Vaccine for Cross-Reactive Mucosal and Systemic Antibody Responses Against SARS-CoV-2

FRONTIERS IN IMMUNOLOGY, 13.

By: K. Nguyen n, S. Mantooth n, M. Vrabel  n & D. Zaharoff n

author keywords: Intranasal vaccination; COVID-19; mucosal immunity; SARS-CoV-2; Receptor binding domain (RBD); chitosan; CpG
MeSH headings : Animals; Antibody Formation; COVID-19 / prevention & control; COVID-19 Vaccines; Humans; Immunoglobulin G; Mice; SARS-CoV-2; Vaccines, Subunit
TL;DR: Data indicate that the designed vaccine platform is versatile, adaptable and capable of overcoming key constraints of current COVID-19 vaccines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: May 31, 2022

2021 article

ONCO-IMMUNOLOGICAL MECHANISMS OF FOCAL ABLATION AND LOCALIZED IL-12 IMMUNOTHERAPY

Vrabel, M., Zaharoff, D., & Mantooth, S. (2021, November). JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 9, pp. A650–A650.

By: M. Vrabel  n, D. Zaharoff n & S. Mantooth n

TL;DR: In the spontaneously metastatic LLC model, delivering CS/IL-12 two days before treatment, either resection or cryoablation, reduced the number of metastatic lung nodules and furthermore prevented the recurrence of the primary tumor after resection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 18, 2022

2021 journal article

Safety and Pharmacokinetics of Intravesical Chitosan/Interleukin-12 Immunotherapy in Murine Bladders

BLADDER CANCER, 7(4), 427–437.

By: K. Nguyen n, E. Wagner n, M. Vrabel  n, S. Mantooth n, D. Meritet n & D. Zaharoff n

author keywords: Bladder cancer; Interleukin-12; immunotherapy; chitosan; intravesical
TL;DR: The lack of cystitis and acute inflammation justifies continued investigation of intravesical CS/IL-12 immunotherapy in larger animals and patients with bladder cancer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 10, 2022

2020 article

INTRATUMORAL INTERLEUKIN-12 ADMINISTERED AFTER CRYOABLATION DOES NOT IMPROVE SURVIVAL IN MULTIPLE BILATERAL MURINE MODELS

Vrabel, M., Schulman, J., & Zaharoff, D. (2020, November). JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 8, pp. A277–A278.

By: M. Vrabel  n, J. Schulman n & D. Zaharoff n

TL;DR: This study hypothesized that intratumoral injection of IL-12 after cryo would activate a strong T cell response and induce systemic immunity in bilateral tumor models and indicated that the addition of interleukin-12 to cryoablation (cryo) improved tumor burden and survival. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 1, 2021

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