Works (96)

Updated: April 3rd, 2024 20:11

2020 book

Agricultural Genetics

(3rd ed.). Kendall-Hunt Publishing Company.

By: M. Merrill

Source: NC State University Libraries
Added: November 6, 2020

2020 journal article

Physiological response, function of sweat glands, and hair follicle cycling in cattle in response to fescue toxicosis and hair genotype

Journal of Animal Science, 98(3).

By: J. Eisemann n, M. Ashwell n, T. Devine n, D. Poole n, M. Poore n & K. Linder n

author keywords: beef heifers; hair follicle; prolactin receptor; slick hair trait; sweat gland; tall fescue
MeSH headings : Animal Feed; Animals; Cattle / genetics; Cattle / physiology; Cattle Diseases / microbiology; Cattle Diseases / physiopathology; Diet / veterinary; Endophytes / physiology; Female; Festuca / microbiology; Gene Expression Regulation; Genotype; Hair; Hair Follicle / physiology; Heat-Shock Response; Mycotoxicosis / microbiology; Mycotoxicosis / physiopathology; Mycotoxicosis / veterinary; Plant Poisoning / microbiology; Plant Poisoning / physiopathology; Plant Poisoning / veterinary; Sweat Glands / physiology
TL;DR: EI fescue resulted in increased ST, changes in hair follicle cycling that support greater hair growth, and decreased TEWL for heifers with the W compared to S genotype suggesting greater heat stress in response to EI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 1, 2020

2020 article

miRNAs explain the variation in muscle and blood transcriptomes of beef calves born from dams with or without energy restriction during late gestation

Carvalho, E. B., Sanglard, L. P., Nascimento, M., Moriel, P., Sommer, J., Merrill, M., … Serao, N. (2020, November). JOURNAL OF ANIMAL SCIENCE, Vol. 98, pp. 165–165.

author keywords: Fetal-programming; maternal nutrition; post-transcriptional regulation
TL;DR: Using RNA-seq data, a large amount of the variation of DEGs was identified, with the identification of important miRNAs related to muscle development and immune system and MiR-21 regulates immune system by different pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 8, 2021

2019 journal article

Characterization of gene expression in naturally occurring feline degenerative joint disease-associated pain

The Veterinary Journal, 243, 42–47.

By: M. Ashwell n, M. Freire n, A. O’Nan n, J. Benito n, J. Hash n, R. McCulloch*, B. Lascelles n

author keywords: Cat; Degenerative joint disease; Neurobiological signature; Osteoarthritis; Pain
MeSH headings : Animals; Cat Diseases / genetics; Cats; Female; Ganglia, Spinal / metabolism; Ganglia, Spinal / physiopathology; Gene Expression; Gene Expression Profiling; Lumbosacral Region / physiopathology; Male; Osteoarthritis, Spine / veterinary; Pain / genetics; Pain / veterinary; Spinal Cord Dorsal Horn / metabolism; Spinal Cord Dorsal Horn / physiopathology
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, Web Of Science
Added: February 11, 2019

2018 journal article

Articular cartilage gene expression patterns in the tissue surrounding the impact site following applications of shear and axial loads

BMC Musculoskeletal Disorders, 19(1).

By: R. McCulloch n, P. Mente n, A. O’Nan n & M. Ashwell n

author keywords: Osteoarthritis; Porcine; Articular injury
MeSH headings : Animals; Cartilage, Articular / metabolism; Cartilage, Articular / pathology; Collagen Type II / genetics; Collagen Type II / metabolism; Gene Expression Profiling / methods; Gene Expression Regulation, Enzymologic; Osteoarthritis, Knee / genetics; Osteoarthritis, Knee / metabolism; Osteoarthritis, Knee / pathology; Patella / metabolism; Patella / pathology; Stress, Mechanical; Sus scrofa; Time Factors; Tissue Culture Techniques; Transcriptome; fas Receptor / genetics; fas Receptor / metabolism
TL;DR: The results suggest that a more physiologically valid shear load may induce more damage to surrounding articular cartilage than a normal load alone. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: January 14, 2019

2018 conference paper

Effect of energy restriction during late gestation in the skeletal muscle and blood transcriptome of Angus calves after preconditioning

Proceedings of the World Congress on Genetics Applied to Livestock Production, 11(646). http://www.wcgalp.org/system/files/proceedings/2018/effect-energy-restriction-during-late-gestation-skeletal-muscle-and-blood-transcriptome-angus-calves.pdf

By: L. Sanglard, M. Nascimento, P. Moriel, J. Sommer, M. Ashwell, M. Duarte, N. Serão

Source: NC State University Libraries
Added: November 6, 2020

2018 journal article

Genetic Parameter Estimates for Metabolizing Two Common Pharmaceuticals in Swine

Frontiers in Genetics, 9(FEB).

By: J. Howard n, M. Ashwell n, R. Baynes n, J. Brooks n, J. Yeatts n & C. Maltecca n

Contributors: J. Howard n, M. Ashwell n, R. Baynes n, J. Brooks n, J. Yeatts n & C. Maltecca n

author keywords: swine; pharmacogenomics; heritability; fenbendazole; flunixin meglumine
TL;DR: A low to moderate proportion of the phenotypic variation in metabolizing fenbendazole and flunixin meglumine drug metabolism was explained by genetics in the current study. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Impact of energy restriction during late gestation on the muscle and blood transcriptome of beef calves after preconditioning

BMC Genomics, 19(1).

author keywords: RNA-seq; Fetal development; Fetal programming; Gene expression
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Cattle / blood; Cattle / genetics; Cattle / growth & development; Cattle / metabolism; Female; Gene Regulatory Networks; Male; Muscle, Skeletal / metabolism; Pregnancy; Transcriptome
TL;DR: In conclusion, maternal energy restriction during late gestation may limit the expression of genes in the muscle and increase expression in the blood of calves and alterations in the intra-uterine environment can modify prenatal development with lasting consequences to adult life. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: October 16, 2018

2017 journal article

Gene co-expression network analysis identifies porcine genes associated with variation in metabolizing fenbendazole and flunixin meglumine in the liver

Scientific Reports, 7(1).

By: J. Howard n, M. Ashwell n, R. Baynes n, J. Brooks n, J. Yeatts n & C. Maltecca n

Contributors: J. Howard n, M. Ashwell n, R. Baynes n, J. Brooks n, J. Yeatts n & C. Maltecca n

MeSH headings : Animals; Antinematodal Agents / pharmacokinetics; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Female; Fenbendazole / pharmacokinetics; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Liver / drug effects; Liver / metabolism; Male; Sus scrofa / genetics; Transcriptome
TL;DR: The objective was to identify individual genes and gene networks involved in metabolizing fenbendazole (FBZ) and flunixin meglumine (FLU) in swine liver to allow for greater insight into FBZ and FLU metabolism. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2015 speech

Animal Science Biotechnology in the Classroom

Merrill, M. S. (2015, July). Presented at the Agricultural Biotechnology in the Classroom Conference, Raleigh, NC.

By: M. Merrill

Event: Agricultural Biotechnology in the Classroom Conference at Raleigh, NC

Source: NC State University Libraries
Added: May 21, 2022

2015 journal article

Differential Gene Expression across Breed and Sex in Commercial Pigs Administered Fenbendazole and Flunixin Meglumine

PLOS ONE, 10(9), e0137830.

By: J. Howard n, A. O’Nan n, C. Maltecca n, R. Baynes n & M. Ashwell n

Contributors: J. Howard n, . A.T. O'Nan n, C. Maltecca n, R. Baynes n & M. Ashwell n

Ed(s): F. Kobeissy

MeSH headings : Animals; Breeding; Clonixin / analogs & derivatives; Clonixin / pharmacology; Cytochrome P-450 Enzyme System / genetics; Female; Fenbendazole / pharmacology; Gene Expression Regulation / drug effects; Male; Orchiectomy; Real-Time Polymerase Chain Reaction; Sus scrofa / genetics
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2015 speech

Do breed and gender affect how pigs respond to drugs?

Merrill, M. S. (2015, May). Presented at the NC State University Swine Research Day, Clinton, NC.

By: M. Merrill

Event: NC State University Swine Research Day at Clinton, NC

Source: NC State University Libraries
Added: May 21, 2022

2015 article

Effect of dietary copper amount and source on copper metabolism and oxidative stress of weanling pigs in short-term feeding

Huang, Y. L., Ashwell, M. S., Fry, R. S., Lloyd, K. E., Flowers, W. L., & Spears, J. W. (2015, June). JOURNAL OF ANIMAL SCIENCE, Vol. 93, pp. 2948–2955.

By: Y. Huang*, M. Ashwell n, R. Fry n, K. Lloyd n, W. Flowers n & J. Spears n

author keywords: copper; copper metabolism; oxidative stress; pigs
MeSH headings : Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Antioxidants / metabolism; Chlorides / pharmacology; Copper / metabolism; Copper Sulfate / pharmacology; Diet / veterinary; Dietary Supplements; Duodenum / metabolism; Gene Expression Regulation; Ileum / metabolism; Intestinal Mucosa / metabolism; Jejunum / metabolism; Liver / metabolism; Male; Malondialdehyde / metabolism; Oxidative Stress / drug effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Swine / physiology
TL;DR: Feeding weanling pigs increased Cu resulted in modulation of duodenal and liver at the transcription level, and when fed at 225 mg Cu/kg diet, TBCC may cause less oxidative stress in the duodenum than CuSO4. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 book

Agricultural Genetics

(2nd ed.). Dubuque, IA: Kendall Hunt Pub. Co.

By: M. Merrill

Source: NC State University Libraries
Added: February 20, 2022

2014 conference paper

Characterisation of gene expression in naturally occurring feline degenerative joint disease associated pain

Presented at the NC Cartilage and Arthritis Research Alliance.

By: M. Freire, A. O'Nan, J. Benito, J. Hash, M. Ashwell & B. Lascelles

Event: NC Cartilage and Arthritis Research Alliance

Source: NC State University Libraries
Added: May 21, 2022

2014 journal article

Fecal microbial diversity and putative function in captive western lowland gorillas (Gorilla gorilla gorilla), common chimpanzees (Pan troglodytes), Hamadryas baboons (Papio hamadryas) and binturongs (Arctictis binturong)

INTEGRATIVE ZOOLOGY, 9(5), 557–569.

By: E. McKenney n, M. Ashwell n, J. Lambert* & V. Fellner n

author keywords: ecology; fermentation; gastrointestinal microbiota; microbial diversity
MeSH headings : Animals; Bacteria / classification; Bacteria / isolation & purification; Dietary Fiber; Feces / microbiology; Fermentation; Gorilla gorilla / microbiology; Pan troglodytes / microbiology; Papio hamadryas / microbiology; Phylogeny; Sequence Analysis, DNA; Species Specificity; Viverridae / microbiology
TL;DR: Eubacterial profiles were consistent with fermentation data and suggest an increase in diversity with dietary fiber in gorillas, common chimpanzees, Hamadryas baboons and binturongs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Progression of Gene Expression Changes following a Mechanical Injury to Articular Cartilage as a Model of Early Stage Osteoarthritis

Arthritis, 2014, 1–9.

By: R. McCulloch n, M. Ashwell n, C. Maltecca n, A. O'Nan n & P. Mente n

TL;DR: Changes in differential gene expression suggest that the more physiologically relevant shear loading may initially be more damaging to the cartilage and induces more repair efforts after loading. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019

2014 journal article

The effect of breed and gender on drug depletion and differential gene expression associated with drug metabolism after flunixin and fenbendazole administration

Journal of Molecular and Genetic Medicine, 8, 67.

By: M. Ashwell, J. Howard, R. Baynes, A. O’Nan, J. Brooks, J. Yeatts, P. Routh, C. Maltecca

Source: NC State University Libraries
Added: May 21, 2022

2014 conference paper

The effect of breed and gender on drug depletion and differential gene expression associated with drug metabolism after flunixin and fenbendazole administration

Swine in Biomedical Research 2014 International Conference, 31.

By: M. Ashwell, J. Howard, R. Baynes, A. O’Nan, J. Brooks, J. Yeatts, P. Routh, C. Maltecca

Event: Swine in Biomedical Research 2014 International Conference

Source: NC State University Libraries
Added: May 21, 2022

2014 conference paper

The effect of breed and sex on drug depletion and differential gene expression associated with drug metabolism after fenbendazole and flunixin administration

Plant and Animal Genome XXII Conference Proceedings, 262.

By: J. Howard, M. Ashwell, R. Baynes, J. Brooks, J. Yeatts, B. Bellis, P. Routh, C. Maltecca

Event: Plant and Animal Genome XXII Conference

Source: NC State University Libraries
Added: May 21, 2022

2014 journal article

The effect of breed and sex on sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine pharmacokinetic parameters in swine

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 37(6), 531–541.

Contributors: J. Howard n, R. Baynes n, J. Brooks n, J. Yeatts n, B. Bellis n, M. Ashwell n, P. Routh n, . A.T. O'Nan n, C. Maltecca n

MeSH headings : Animals; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Antinematodal Agents / blood; Antinematodal Agents / pharmacokinetics; Benzimidazoles / blood; Ciprofloxacin / blood; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Enrofloxacin; Female; Fenbendazole / blood; Fenbendazole / pharmacokinetics; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Male; Sex Factors; Species Specificity; Sulfamethazine / analogs & derivatives; Sulfamethazine / blood; Sulfamethazine / pharmacokinetics; Swine / metabolism
TL;DR: Whether drug clearance differs across genetic backgrounds and sex for sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine is determined to determine the degree of additive genetic variation utilizing a larger population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Changes in chondrocyte gene expression following in vitro impaction of porcine articular cartilage in an impact injury model

JOURNAL OF ORTHOPAEDIC RESEARCH, 31(3), 385–391.

By: M. Ashwell n, M. Gonda n, K. Gray n, C. Maltecca n, . Audrey T. O'Nan, J. Cassady n, P. Mente n

Contributors: M. Ashwell n, M. Gonda n, K. Gray n, C. Maltecca n, . A.T. O'Nan n, J. Cassady n, P. Mente n

author keywords: articular cartilage; chondrocyte; gene expression; joint injury; osteoarthritis
MeSH headings : Animals; Cartilage, Articular / cytology; Cartilage, Articular / physiology; Chondrocytes / physiology; Female; Knee Injuries / genetics; Knee Injuries / physiopathology; Knee Joint / cytology; Knee Joint / physiology; Models, Genetic; Organ Culture Techniques; Osteoarthritis, Knee / genetics; Osteoarthritis, Knee / physiopathology; Patella / cytology; Patella / physiology; Real-Time Polymerase Chain Reaction; Sus scrofa; Transcriptome / physiology
TL;DR: Ten of the 17 genes were differentially expressed with col1a1 most significantly up‐regulated in the impacted samples, suggesting impacted chondrocytes may have reverted to a fibroblast‐like phenotype. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 chapter

Characterization of gene expression in naturally occurring feline degenerative joint disease associated pain

Presented at the 12th Federation of European Laboratory Animal Science Associations—Spanish Association of Laboratory Animal Science, Barcelona, Spain.

By: A. Freire, A. O'Nan, J. Benito, J. Hash, M. Ashwell & B. Lascelles

Event: 12th Federation of European Laboratory Animal Science Associations—Spanish Association of Laboratory Animal Science at Barcelona, Spain on June 10-13, 2013

Source: NC State University Libraries
Added: May 21, 2022

2013 journal article

Early postnatal kinetics of colostral immunoglobulin G absorption in fed and fasted piglets and developmental expression of the intestinal immunoglobulin G receptor

Journal of Animal Science, 91(1), 211–218.

By: R. Cabrera n, X. Lin n, M. Ashwell n, A. Moeser n & J. Odle n

Contributors: R. Cabrera n, X. Lin n, M. Ashwell n, A. Moeser n & J. Odle n

author keywords: colostral immunoglobulin G; immunoglobulin G receptor; serum immunoglobulin G
MeSH headings : Absorption; Animals; Animals, Newborn; Colostrum / chemistry; Food Deprivation; Gene Expression Regulation, Developmental / drug effects; Immunoglobulin G / administration & dosage; Immunoglobulin G / chemistry; Intestinal Mucosa / metabolism; Intestines / drug effects; Receptors, IgG / genetics; Receptors, IgG / metabolism; Swine / metabolism
TL;DR: The effects of delayed offering of defatted colostrum and age-dependent changes in IgG receptor were modest over the first 24 h of life. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2013 journal article

Effect of dietary copper and breed on gene products involved in copper acquisition, distribution, and use in Angus and Simmental cows and fetuses

JOURNAL OF ANIMAL SCIENCE, 91(2), 861–871.

By: R. Fry n, J. Spears n, K. Lloyd n, A. O'Nan n & M. Ashwell n

author keywords: breed; cattle; copper; deficiency; fetus; placentome
MeSH headings : Animals; Cattle / genetics; Cattle / metabolism; Copper / blood; Copper / pharmacokinetics; Copper / pharmacology; Female; Fetus / metabolism; Gene Expression Regulation / drug effects; Liver / metabolism; Minerals; Pregnancy
TL;DR: Less expression of duodenal Ctr1 and a tendency for less CTR1 suggest that Simmentals have a lesser ability to absorb and utilize dietary Cu, and may explain why Simmental are more prone to Cu deficiency than Angus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 conference paper

Exploring cellular trace mineral metabolism in bovine and porcine tissues

Fry, R. S., Spears, J. W., Ashwell, M. S., & Hansen, S. L. (2013, July 8). Presented at the 2013 Joint Annual Meeting of ASDA and ASAS, Indianapolis, IN.

By: R. Fry, J. Spears, M. Ashwell & S. Hansen

Event: 2013 Joint Annual Meeting of ASDA and ASAS at Indianapolis, IN on July 8-12, 2013

Source: NC State University Libraries
Added: May 21, 2022

2012 book

Agricultural Genetics

(1st ed.). Dubuque, IA: Kendall-Hunt Publishing Company.

By: M. Ashwell

Source: NC State University Libraries
Added: May 21, 2022

2012 journal article

Amount and source of dietary copper affects small intestine morphology, duodenal lipid peroxidation, hepatic oxidative stress, and mRNA expression of hepatic copper regulatory proteins in weanling pigs

JOURNAL OF ANIMAL SCIENCE, 90(9), 3112–3119.

By: R. Fry n, M. Ashwell n, K. Lloyd n, A. O'Nan n, W. Flowers n, K. Stewart n, J. Spears n

author keywords: copper; copper proteins; mucosal histology; oxidative stress; pigs
MeSH headings : Animals; Copper / metabolism; Copper / pharmacology; Duodenum / drug effects; Duodenum / metabolism; Gene Expression Regulation / drug effects; Intestinal Mucosa / drug effects; Lipid Peroxidation / drug effects; Liver / metabolism; Male; Malondialdehyde / metabolism; Oxidative Stress / drug effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Real-Time Polymerase Chain Reaction / veterinary; Swine / blood; Swine / metabolism
TL;DR: Results of this study indicated that, when fed at 225 mg Cu/kg diet, TBCC may cause less oxidative stress in the duodenum than CuSO(4), and feeding weanling pigs increased Cu resulted in modulation of certain Cu transporters and chaperones at the transcription level. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Identification of stable normalization genes for quantitative real-time PCR in porcine articular cartilage

Journal of Animal Science and Biotechnology, 3(1).

By: R. McCulloch n, M. Ashwell n, A. O’Nan n & P. Mente n

author keywords: Cartilage; Housekeeping; Normalization; Porcine; Reference; Stability
TL;DR: The purpose of this study was to identify the most stable housekeeping genes in porcine articular cartilage subjected to a mechanical injury from a panel of 10 candidate genes. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

2011 journal article

A genome-wide association study of direct gestation length in US Holstein and Italian Brown populations

ANIMAL GENETICS, 42(6), 585–591.

By: C. Maltecca n, K. Gray n, K. Weigel*, J. Cassady n & M. Ashwell n

Contributors: C. Maltecca n, K. Gray n, K. Weigel*, J. Cassady n & M. Ashwell n

author keywords: association study; cattle; direct gestation length
MeSH headings : Animals; Cattle / genetics; Cattle / physiology; Female; Genome-Wide Association Study / veterinary; Male; Pedigree; Polymorphism, Single Nucleotide; Pregnancy / physiology
TL;DR: This study identifies target regions for the investigation of direct foetal effects, which are a significant factor in determining the ease of calving, through a genome-wide association study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2011 conference paper

Articular cartilage chondrocyte gene expression alterations following shear and axial impactions

Presented at the 57th annual meeting of the Orthopedic Research Society.

By: R. McCulloch, M. Ashwell, A. O’Nan, C. Maltecca & P. Mente

Event: 57th annual meeting of the Orthopedic Research Society

Source: NC State University Libraries
Added: May 21, 2022

2011 journal article

Investigation of breed and sex effects on cytochrome P450 gene expression in cattle liver

RESEARCH IN VETERINARY SCIENCE, 90(2), 235–237.

By: M. Ashwell n, R. Fry n, J. Spears n, A. O'Nan n & C. Maltecca n

Contributors: M. Ashwell n, R. Fry n, J. Spears n, . A.T. O'Nan n & C. Maltecca n

author keywords: Cytochrome P450; Cattle; Gene expression; Liver
MeSH headings : Animals; Cattle / genetics; Cattle / metabolism; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Female; Gene Expression Regulation, Enzymologic / genetics; Gene Expression Regulation, Enzymologic / physiology; Liver / enzymology; Male; Sex Characteristics
TL;DR: Breed and/or sex of an animal may need to be considered before administering a dose of a xenobiotic due to the potential for harmful drug residues in foodstuffs as well as improper treatment of disease conditions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2010 speech

Animal functional genomics at NC State University

Merrill, M. S. (2010, February). Presented at the NC A&T University, Department of Animal Sciences.

By: M. Merrill

Event: NC A&T University, Department of Animal Sciences

Source: NC State University Libraries
Added: May 21, 2022

2010 journal article

Dietary iron affects mRNA expression of porcine copper transporters

The FASEB Journal, 24(S1).

By: R. Fry n, J. Spears n, S. Hansen* & M. Ashwell n

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

2010 conference paper

Differential gene expression of chrondocytes from a porcine impact injury model using suitable reference genes

Transactions of the 56th annual meeting of the Orthopedic Research Society. Presented at the 56th annual meeting of the Orthopedic Research Society.

By: R. McCulloch, M. Ashwell, A. O’Nan & P. Mente

Event: 56th annual meeting of the Orthopedic Research Society

Source: NC State University Libraries
Added: May 21, 2022

2010 journal article

Duodenal copper transporters in cattle are affected by breed

Journal of Animal Science, 88(Supplement 2), 11.

By: R. Fry, M. Ashwell & J. Spears

Source: NC State University Libraries
Added: May 21, 2022

2010 journal article

Effect of level and source of dietary copper on copper metabolism in the small intestine of weanling pigs

Journal of Animal Science, 88(Supplement 1), 499.

By: R. Fry, M. Ashwell, W. Flowers, K. Stewart & J. Spears

Source: NC State University Libraries
Added: May 21, 2022

2010 journal article

Effects of dietary iron and age on cellular copper metabolism in liver of weanling pigs

Journal of Animal Science, 88(Supplement 1), 499.

By: R. Fry, J. Spears, S. Hansen, H. Liu & M. Ashwell

Source: NC State University Libraries
Added: May 21, 2022

2010 conference paper

Evaluating the QiaAMP DNA stool kit for metagenomic studies in Arctictis binturong

McKenney, E. A., O’Nan, A. T., Fellner, V., & Ashwell, M. S. (2010, August). Presented at the Comparative Nutrition Society Annual Conference, Tucson, AZ.

By: E. McKenney, A. O’Nan, V. Fellner & M. Ashwell

Event: Comparative Nutrition Society Annual Conference at Tucson, AZ

Source: NC State University Libraries
Added: May 21, 2022

2010 journal article

High dietary iron reduces transporters involved in iron and manganese metabolism and increases intestinal permeability in calves

JOURNAL OF DAIRY SCIENCE, 93(2), 656–665.

By: S. Hansen n, M. Ashwell n, A. Moeser n, R. Fry n, M. Knutson* & J. Spears n

author keywords: cattle; iron; manganese; metal transporter
MeSH headings : Animals; Body Weight / physiology; Cattle / metabolism; Cattle / physiology; Diet / veterinary; Duodenum / chemistry; Duodenum / drug effects; Gene Expression Regulation / drug effects; Heart / drug effects; Iron / analysis; Iron / blood; Iron / metabolism; Iron, Dietary / metabolism; Iron, Dietary / pharmacology; Liver / drug effects; Liver / metabolism; Male; Manganese / analysis; Manganese / blood; Manganese / metabolism; Membrane Transport Proteins / metabolism; Myocardium / chemistry; Oxidative Stress / drug effects
TL;DR: Feeding calves a diet high in Fe induced a signal cascade (hepcidin) designed to reduce absorption of Fe (via reduced protein expression of ferroportin and DMT1) in a manner similar to that reported in rodents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Proteins involved in iron metabolism in beef cattle are affected by copper deficiency in combination with high dietary manganese, but not by copper deficiency alone

JOURNAL OF ANIMAL SCIENCE, 88(1), 275–283.

By: S. Hansen n, N. Trakooljul n, H. Liu n, J. Hicks n, M. Ashwell n & J. Spears n

author keywords: cattle; copper; iron; metal transporter
MeSH headings : Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Cation Transport Proteins / genetics; Cation Transport Proteins / metabolism; Cattle; Copper / blood; Copper / deficiency; Diet / veterinary; Dose-Response Relationship, Drug; Female; Gene Expression Regulation / drug effects; Iron / metabolism; Male; Manganese / administration & dosage; Manganese / pharmacology
TL;DR: It is confirmed that Cu deficiency alone did affect hepatic gene expression of hepcidin and ferroportin, but did not affect duodenal expression of proteins important in Fe metabolism, however, the addition of 500 mg of Mn/kg of DM to a diet low in Cu reduced duodentally expression of the Fe import protein DMT1. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 21(9), 848–855.

By: M. Ashwell n, R. Ceddia n, R. House n, J. Cassady n, E. Eisen n, T. Eling*, J. Collins*, S. Grissom*, J. Odle n

Contributors: M. Ashwell n, R. Ceddia n, R. House n, J. Cassady n, E. Eisen n, T. Eling*, J. Collins*, S. Grissom*, J. Odle n

author keywords: Gene expression; Mice; Liver, Conjugated linoleic acid; Obesity, Hepatic steatosis, Fatty liver
MeSH headings : Animals; Fatty Liver / genetics; Fatty Liver / metabolism; Gene Expression Profiling; Hepatocyte Nuclear Factor 4 / genetics; Linoleic Acids, Conjugated / pharmacology; Liver / metabolism; Male; Mice; Obesity / genetics; Obesity / metabolism
TL;DR: While surprisingly few genes in lipid metabolism were impacted, pathway analysis found that protein kinase A and cyclic adenosine monophosphate pathways signaling pathways were affected by CLA treatment and 98 of the 775 genes were found to be regulated by hepatocyte nuclear factor 4alpha, a transcription factor important in controlling liver metabolic status. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2009 conference paper

Differential chondrocyte gene expression following in vitro shear and axial impactions to porcine articular cartilage

BMES 2009 Annual Fall Meeting, 134.

By: R. McCulloch, M. Ashwell & P. Mente

Event: BMES 2009 Annual Fall Meeting

Source: NC State University Libraries
Added: May 27, 2022

2009 journal article

Effects of a long-term copper deficiency on gene expression profiles of copper transporters and chaperones in the intestine and liver of cattle

Journal of Animal Science, 87(Supplement 2), 561.

By: R. Fry, M. Ashwell, S. Hansen, T. Engle, H. Han & J. Spears

Source: NC State University Libraries
Added: May 21, 2022

2009 journal article

Gene expression in chicken and turkey tibia growth plates is affected by oxygen concentrations during the plateau stage of incubation

Journal of Poultry Science, 88(Suppl 1), 61.

By: E. Oviedo-Rondon, M. Ashwell & M. Wineland

Source: NC State University Libraries
Added: May 27, 2022

2009 journal article

High dietary iron negatively impacts gene products important in iron and manganese metabolism in young calves

Journal of Animal Science, 87(Suppl 2), 516.

By: S. Hansen, M. Ashwell, R. Fry & J. Spears

Source: NC State University Libraries
Added: May 21, 2022

2009 conference paper

Temporal differences in chondrocyte gene expression following an in vitro cartilage injury

Presented at the 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, NV.

By: P. Mente, M. Gonda & M. Ashwell

Event: 55th Annual Meeting of the Orthopaedic Research Society at Las Vegas, NV

Source: NC State University Libraries
Added: May 27, 2022

2009 journal article

The addition of high manganese to a copper-deficient diet further depresses copper status and growth of cattle

BRITISH JOURNAL OF NUTRITION, 101(7), 1068–1078.

By: S. Hansen n, M. Ashwell n, L. Legleiter n, R. Fry n, K. Lloyd n & J. Spears n

author keywords: Cattle; Copper; Growth; Manganese
MeSH headings : Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Body Weight / drug effects; Cattle / growth & development; Cattle / metabolism; Copper / deficiency; Cyclooxygenase 1 / genetics; Depression, Chemical; Female; Gene Expression / drug effects; Liver / metabolism; Male; Manganese / administration & dosage; Manganese / analysis; Nutritional Status; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction / methods; Superoxide Dismutase / genetics; Superoxide Dismutase-1; Time Factors
TL;DR: In conclusion, feeding a Cu − deficient diet in combination with high Mn negatively affected the growth and Cu status of beef cattle. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 conference paper

Effects of long-term copper deficiency on gene profiles of copper transporters and chaperones in the liver of cattle

Proceedings of the 13th International Symposium on Trace Elements in Man and Animals, 79–80.

By: R. Fry, M. Ashwell, S. Hansen, T. Engle, H. Han & J. Spears

Event: 13th International Symposium on Trace Elements in Man and Animals

Source: NC State University Libraries
Added: May 27, 2022

2008 journal article

Gene expression profiling of chondrocytes from a porcine impact injury model

OSTEOARTHRITIS AND CARTILAGE, 16(8), 936–946.

By: M. Ashwell n, A. O'Nan n, M. Gonda n & P. Mente n

author keywords: gene expression; chondrocyte; impact injury model; osteoarthritis
MeSH headings : Animals; Cells, Cultured / metabolism; Chondrocytes / metabolism; Disease Models, Animal; Gene Expression; Gene Expression Profiling / methods; Knee Joint / metabolism; Osteoarthritis / genetics; Osteoarthritis / metabolism; Phenotype; Polymerase Chain Reaction; Swine; Wounds, Nonpenetrating / genetics; Wounds, Nonpenetrating / metabolism
TL;DR: Results using this porcine impact injury model have contributed further evidence that damaged chondrocytes may de-differentiate into fibroblast-like cells and proliferate in an attempt to repair themselves and provide a more complete story about the fate of chondROcytes in articular cartilage following an injury. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 speech

Using genomic tools to improve health and reproduction traits

Merrill, M. S. (2007, September). Presented at the Department of Dairy Science, Virginia Tech, Blacksburg, VA.

By: M. Merrill

Event: Department of Dairy Science, Virginia Tech at Blacksburg, VA

Source: NC State University Libraries
Added: May 27, 2022

2006 journal article

Characterization of a line of pigs previously selected for increased litter size for RBP4 and follistatin

JOURNAL OF ANIMAL BREEDING AND GENETICS, 123(6), 389–395.

By: C. Blowe n, K. Boyette n, M. Ashwell n, E. Eisen n, O. Robison n & J. Cassady n

author keywords: follistatin; litter size; pigs; retinol-binding protein 4
MeSH headings : Animals; Female; Follistatin / genetics; Litter Size / genetics; Male; Polymerase Chain Reaction; Pregnancy; Receptors, Estrogen / genetics; Retinol-Binding Proteins / genetics; Sus scrofa / genetics; Sus scrofa / physiology
TL;DR: Responses to selection for increased litter size in pigs could not be attributed to effects at the ESR, RBP4 or FS loci. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Comparative mapping of bovine chromosome 27 with human chromosome 8 near a dairy form QTL in cattle

CYTOGENETIC AND GENOME RESEARCH, 112(1-2), 98–102.

By: E. Connor*, M. Ashwell n, R. Schnabel* & J. Williams*

MeSH headings : Animals; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 8; Chromosomes, Mammalian; DNA Primers; Dairying; Female; Gene Amplification; Humans; Mice; Molecular Sequence Data; Quantitative Trait Loci
TL;DR: Eight genes from human chromosome 8 were selected for mapping in cattle to improve breakpoint resolution and confirm gene order on the comparative map near the 40 cM region of the BTA27 linkage map where a QTL affecting dairy form had previously been identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Refinement of quantitative trait loci on bovine chromosome 18 affecting health and reproduction in US Holsteins

ANIMAL GENETICS, 37(3), 273–275.

By: S. Muncie n, J. Cassady n & M. Ashwell n

author keywords: Bos taurus chromosome 18; pregnancy rate; quantitative trait locus
MeSH headings : Animals; Cattle / genetics; Chromosomes, Mammalian; Female; Fertility / genetics; Genetic Markers; Genotype; Male; Pedigree; Pregnancy; Pregnancy Rate; Quantitative Trait Loci
TL;DR: Analysis of the extended pedigree detected significant and suggestive QTL for DPR, productive life and somatic cell score and further analysis is underway to refine the QTL region so that positional candidate genes can be identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 speech

Transcript profiling of chondrocytes in a porcine impact injury model of osteoarthritis

Merrill, M. S. (2006, August). Presented at the International Society of Animal Genetics conference, Porto Seguro, Brazil.

By: M. Merrill

Event: International Society of Animal Genetics conference at Porto Seguro, Brazil

Source: NC State University Libraries
Added: May 27, 2022

2005 journal article

Detection of quantitative trait loci influencing conformation traits and calving ease in Holstein-Friesian cattle

JOURNAL OF DAIRY SCIENCE, 88(11), 4111–4119.

By: M. Ashwell n, D. Heyen*, J. Weller*, M. Ron*, T. Sonstegard, C. Van Tassell, H. Lewin*

author keywords: genome scan; dairy; conformation; quantitative trait loci
MeSH headings : Animals; Body Constitution / genetics; Breeding; Cattle / genetics; Cell Count; Extremities / anatomy & histology; Female; Genotype; Hoof and Claw / anatomy & histology; Lactation / genetics; Male; Mammary Glands, Animal / anatomy & histology; Milk / cytology; Parturition / genetics; Phenotype; Pregnancy; Quantitative Trait Loci / genetics; Regression Analysis
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Fine-mapping milk production quantitative trait loci on BTA6: Analysis of the bovine osteopontin gene

Proceedings of the National Academy of Sciences, 102(19), 6896–6901.

By: R. Schnabel*, J. Kim*, M. Ashwell*, T. Sonstegard*, C. Van Tassell*, E. Connor*, J. Taylor*

author keywords: linkage disequilibrium
MeSH headings : Alleles; Amino Acid Sequence; Animals; Base Sequence; Cattle; Chromosome Mapping; Cloning, Molecular; Conserved Sequence; Genotype; Haplotypes; Humans; Lactation / genetics; Lactation / physiology; Linkage Disequilibrium; Lod Score; Microsatellite Repeats; Milk / metabolism; Models, Statistical; Molecular Sequence Data; Osteopontin; Phylogeny; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Sequence Analysis, DNA; Sialoglycoproteins / genetics; Species Specificity
TL;DR: Bovine chromosome six (BTA6) harbors up to six quantitative trait loci influencing the milk production of dairy cattle, and it is demonstrated that the motif harboring OPN3907, which is upstream of the promoter and within a region known to harbor tissue-specific osteopontin regulatory elements, is moderately conserved among mammals. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2005 journal article

Whole-genome scan to detect QTL for milk production, conformation, fertility and functional traits in two US Holstein families

ANIMAL GENETICS, 36(5), 408–416.

By: R. Schnabel*, T. Sonstegard*, J. Taylor* & M. Ashwell n

author keywords: conformation; fertility; milk production; quantitative trait loci
MeSH headings : Animals; Bayes Theorem; Body Constitution / genetics; Cattle / genetics; Dairying / methods; Female; Fertility / genetics; Genomics / methods; Lactation / genetics; Microsatellite Repeats / genetics; Quantitative Trait Loci; Regression Analysis
TL;DR: A genome scan was conducted in two US Holstein half-sib families to identify quantitative trait loci affecting milk production and conformation traits using the granddaughter design, but results from the two methods of analysis were only concordant for QTL location and level of significance in eight instances. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

An expanded comparative map of bovine chromosome 27 targeting dairy form QTL regions

Animal Genetics, 35(4), 265–269.

By: E. Connor*, T. Sonstegard*, M. Ashwell*, G. Bennett* & J. Williams*

author keywords: comparative mapping; dairy form; RH mapping; SNP
MeSH headings : Animals; Base Sequence; Body Constitution / genetics; Cattle / genetics; Chromosome Mapping; Chromosomes, Artificial, Bacterial; Chromosomes, Mammalian / genetics; DNA Primers; Dairying; Humans; Microsatellite Repeats / genetics; Molecular Sequence Data; Quantitative Trait Loci / genetics; Radiation Hybrid Mapping; Sequence Analysis, DNA; Synteny / genetics
TL;DR: The chromosomal mapping of 10 selected gene-associated markers to bovine linkage and radiation hybrid maps is described to improve the breakpoint resolution in the human-bovine comparative map near two previously identified quantitative trait loci for the linear type trait, dairy form. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

2004 journal article

Detection of Quantitative Trait Loci Affecting Milk Production, Health, and Reproductive Traits in Holstein Cattle

Journal of Dairy Science, 87(2), 468–475.

By: M. Ashwell, D. Heyen*, T. Sonstegard, C. Van Tassell, Y. Da*, P. VanRaden*, M. Ron*, J. Weller*, H. Lewin*

author keywords: quantitative trait locus; pregnancy rate; milk production traits
MeSH headings : Animals; Breeding; Cattle / genetics; Cell Count; Chromosome Mapping; Female; Fertility / genetics; Genotype; Health Status; Lactation / genetics; Lipids / analysis; Male; Microsatellite Repeats; Milk / chemistry; Milk / cytology; Milk Proteins / analysis; Phenotype; Pregnancy; Quantitative Trait Loci / genetics; Reproduction / genetics
TL;DR: Within-family analysis detected putative QTL associated with pregnancy rate on six chromosomes, with the effect on chromosome 18 being the most significant statistically. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

2004 journal article

Mapping Quantitative Trait Loci Affecting Dairy Conformation to Chromosome 27 in Two Holstein Grandsire Families

Journal of Dairy Science, 87(2), 450–457.

By: C. Van Tassell*, T. Sonstegard* & M. Ashwell*

author keywords: quantitative trait loci; dairy cattle; dairy conformation
MeSH headings : Animals; Breeding; Cattle / genetics; Chromosome Mapping; Dairying; Female; Genetic Markers; Genotype; Lactation / genetics; Lipids / analysis; Lod Score; Male; Microsatellite Repeats; Milk / chemistry; Quantitative Trait Loci / genetics
TL;DR: Identification of quantitative trait loci affecting dairy conformation and fat components supports results reported by other groups, providing additional evidence that genes affecting fat metabolism are located on bovine chromosome 27. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

2004 journal article

Physical and linkage mapping of mammary-derived expressed sequence tags in cattle

Genomics, 83(1), 148–152.

By: E. Connor*, T. Sonstegard*, J. Keele*, G. Bennett*, J. Williams*, R. Papworth*, C. Van Tassell*, M. Ashwell*

author keywords: RH mapping; linkage mapping; SNP; cattle; EST
MeSH headings : Animals; Cattle / genetics; Chromosome Mapping / methods; Chromosomes, Mammalian / genetics; Cricetinae; Expressed Sequence Tags; Gene Library; Genetic Markers; Humans; Mammary Glands, Animal / metabolism; Physical Chromosome Mapping; Radiation Hybrid Mapping; Synteny
TL;DR: The physical and linkage mapping of 42 gene-associated markers developed from mammary gland-derived expressed sequence tags to the cattle genome improve the resolution of the human-bovine comparative maps and will assist future efforts to integrate bovine RH and linkage map data. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2003 journal article

Genetic Diversity and Background Linkage Disequilibrium in the North American Holstein Cattle Population

Journal of Dairy Science, 86(12), 4137–4147.

By: R. Vallejo*, Y. Li*, G. Rogers* & M. Ashwell*

author keywords: background linkage disequilibrium; genetic diversity; Holstein; linkage disequilibrium
MeSH headings : Animals; Cattle / genetics; Fluorescent Dyes; Genetic Variation / genetics; Genotype; Heterozygote; Linkage Disequilibrium / genetics; Male; Microsatellite Repeats; North America; Polymerase Chain Reaction
TL;DR: The results suggest that the observed LD is not purely due to genetic drift and migration and that a portion might be due to DLD, which raises the hopes of successful fine-localization of genes for complex traits using LD mapping. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

2003 speech

Genetic approaches to improving health and reproduction in cattle

Merrill, M. S. (2003, November). Presented at the National Pork Board’s Genetics of Pig Health Symposium, Des Moines, IA.

By: M. Merrill

Event: National Pork Board’s Genetics of Pig Health Symposium at Des Moines, IA

Source: NC State University Libraries
Added: May 27, 2022

2002 journal article

A radiation hybrid map of bovine chromosome 27

Animal Genetics, 33(1), 75–76.

By: M. Ashwell*, T. Sonstegard*, S. Kata* & J. Womack*

MeSH headings : Animals; Cattle / genetics; Radiation Hybrid Mapping / veterinary
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

2002 journal article

Characterization and expression of the bovine growth hormone-releasing hormone (GHRH) receptor

Domestic Animal Endocrinology, 22(4), 189–200.

By: E. Connor*, M. Ashwell* & G. Dahl*

MeSH headings : Amino Acid Sequence; Animals; Cattle / genetics; Cloning, Molecular; DNA, Complementary / chemistry; DNA, Complementary / genetics; Gene Expression / drug effects; Growth Hormone / blood; Growth Hormone / pharmacology; Humans; Insulin-Like Growth Factor I / analysis; Molecular Sequence Data; Pituitary Gland / chemistry; RNA, Messenger / analysis; Receptors, Neuropeptide / chemistry; Receptors, Neuropeptide / genetics; Receptors, Pituitary Hormone-Regulating Hormone / chemistry; Receptors, Pituitary Hormone-Regulating Hormone / genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Analysis, DNA
TL;DR: Cloned and sequenced a complete bovine pituitary GHRH receptor cDNA in order to study its expression in cattle, and examined the effect of bST treatment of dairy heifers using relative and real-time RT-PCR to gain a better understanding of G HRH receptor gene regulation in ruminants. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

2002 conference paper

Fine-mapping of QTL affecting protein percent and fat percent on BTA6 in a popular U.S. Holstein family.

World Congress of Genetics Applied to Livestock Production Proceedings, 31, 123–126.

By: M. Ashwell, R. Schnabel, T. Sonstegard & C. Van Tassell

Source: NC State University Libraries
Added: May 27, 2022

2002 chapter

Genetics, Cattle Genomics

In H. Roginski, J. W. Fuquay, & P. F. Fox (Eds.), Encyclopedia of Dairy Sciences (Vol. 2, pp. 1219–1224).

By: C. Van Tassell*, T. Sonstegard*, M. Ashwell*, E. Connor* & S. Kappes

Ed(s): H. Roginski, J. Fuquay & P. Fox

Sources: Crossref, NC State University Libraries
Added: February 20, 2022

2002 speech

Genomic tools and techniques used in livestock species

Merrill, M. S. (2002, May). Presented at the American College of Veterinary Internal Medicine Annual Meeting, Dallas, TX.

By: M. Merrill

Event: American College of Veterinary Internal Medicine Annual Meeting at Dallas, TX

Source: NC State University Libraries
Added: May 27, 2022

2002 conference paper

Genomic tools and techniques used in livestock species

American College of Veterinary Internal Medicine Forum Proceedings, 20, 261–263.

By: M. Ashwell

Source: NC State University Libraries
Added: May 27, 2022

2002 conference paper

Isolation of DNA from buccal and vaginal samples using the BuccalAmp kit

Epicentre Forum, 9, 13.

By: R. Sadler, M. Anderson & M. Ashwell

Source: NC State University Libraries
Added: May 27, 2022

2002 conference paper

Mapping genes related to disease resistance and milk production in Holsteins

American College of Veterinary Internal Medicine Forum Proceedings, 20, 264–266.

By: M. Ashwell, T. Sonstegard & C. Van Tassell

Source: NC State University Libraries
Added: May 27, 2022

2002 speech

Mapping genes related to disease resistance and milk production in US Holsteins

Merrill, M. S. (2002, May). Presented at the American College of Veterinary Internal Medicine Annual Meeting, Dallas, TX.

By: M. Merrill

Event: American College of Veterinary Internal Medicine Annual Meeting at Dallas, TX

Source: NC State University Libraries
Added: May 27, 2022

2002 speech

Molecular approaches to improved disease resistance in dairy cattle

Merrill, M. S. (2002, November). Presented at the National Animal Disease Center, Ames, IA.

By: M. Merrill

Event: National Animal Disease Center at Ames, IA

Source: NC State University Libraries
Added: May 27, 2022

2001 journal article

A Genome Scan To Identify Quantitative Trait Loci Affecting Economically Important Traits in a US Holstein Population

Journal of Dairy Science, 84(11), 2535–2542.

By: M. Ashwell*, C. Van Tassell* & T. Sonstegard*

author keywords: quantitative trait loci; microsatellite markers; conformation traits; milk production traits
MeSH headings : Alleles; Animals; Breeding; Cattle / genetics; Chromosome Mapping / veterinary; Female; Genotype; Lactation / genetics; Male; Microsatellite Repeats; Milk / chemistry; Quantitative Trait, Heritable
TL;DR: The quantitative trait loci identified in this genome scan may be useful for marker-assisted selection to increase the rate of genetic improvement on traits such as disease resistance and conformation traits associated with fitness while accelerating genetic improvement for production. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

2001 journal article

Dairy cattle genomics: Tools to accelerate genetic improvement?

Journal of Animal Science, 79(E-Suppl), E307.

By: T. Sonstegard, C. Van Tassell* & M. Ashwell

TL;DR: Traditional selection based on genetic merit calculated from phenotypic and pedigree informa- tion has been tremendously effective at improving pro- duction in dairy cattle, but genetic improve- ment could be accelerated even further for yield and other economically important traits by directly select- ing upon the genetic differences underlying the pheno- types. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

2001 speech

Identification of QTL affecting milk production traits on bovine chromosome 6

Merrill, M. S. (2001, March). Presented at the Penn State University, Animal Science department, University Park, PA.

By: M. Merrill

Event: Penn State University, Animal Science department at University Park, PA

Source: NC State University Libraries
Added: May 27, 2022

2001 journal article

Isolation, characterization and mapping of the bovine signal peptidase subunit 18 gene

Animal Genetics, 32(4), 232–233.

By: M. Ashwell*, C. Ashwell*, W. Garrett* & G. Bennett*

MeSH headings : Animals; Base Sequence; Cattle / genetics; Chromosome Mapping; DNA, Complementary / chemistry; DNA, Complementary / genetics; DNA, Complementary / isolation & purification; In Situ Hybridization, Fluorescence / veterinary; Membrane Proteins; Molecular Sequence Data; Polymerase Chain Reaction / veterinary; Polymorphism, Genetic / genetics; Sequence Analysis, DNA; Serine Endopeptidases / chemistry; Serine Endopeptidases / genetics
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

2001 speech

Mapping genes related to disease resistance and milk production in dairy cattle

Merrill, M. S. (2001, October). Presented at the Eastern Regional Research Center Health Food Challenges conference, Hunt Valley, MD.

By: M. Merrill

Event: Eastern Regional Research Center Health Food Challenges conference at Hunt Valley, MD

Source: NC State University Libraries
Added: May 27, 2022

2000 speech

A genome scan to identify QTL affecting economically important traits in dairy cattle

Merrill, M. S. (2000, December). Presented at the W.E. Peterson Dairy Genomics Mini-Symposium, Minneapolis, MN.

By: M. Merrill

Event: W.E. Peterson Dairy Genomics Mini-Symposium at Minneapolis, MN

Source: NC State University Libraries
Added: May 27, 2022

2000 journal article

Comparative map alignment of BTA27 and HSA4 and 8 to identify conserved segments of genome containing fat deposition QTL

Mammalian Genome, 11(8), 682–688.

By: T. Sonstegard*, W. Garrett*, M. Ashwell*, G. Bennett*, S. Kappes* & C. Van Tassell*

MeSH headings : Adipose Tissue / metabolism; Animals; Cattle; Chromosome Mapping; Chromosomes / genetics; Chromosomes, Human, Pair 1 / genetics; Chromosomes, Human, Pair 8 / genetics; DNA / genetics; Humans; Hybrid Cells; In Situ Hybridization, Fluorescence; Microsatellite Repeats; Physical Chromosome Mapping; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable; Sequence Alignment
TL;DR: Comparative map alignment strongly suggests the conserved segment orthologous to HSA8p21-q11 contains QTL for fat deposition in cattle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

2000 journal article

Detection of Putative Loci Affecting Milk, Health, and Conformation Traits in a US Holstein Population Using 105 Microsatellite Markers

Journal of Dairy Science, 83(8), 1865–1872.

By: C. Van Tassell*, M. Ashwell* & T. Sonstegard*

author keywords: quantitative trait loci; microsatellite markers; conformation traits; milk production traits
MeSH headings : Alleles; Animals; Breeding; Cattle / genetics; Chromosome Mapping / veterinary; Female; Genotype; Health Status; Lactation; Male; Microsatellite Repeats; Milk / chemistry; Semen
TL;DR: Quantitative trait loci affecting milk yield, health, and conformation traits were studied for eight large US Holstein grandsire families by using the granddaughter design and a trait-wise critical value of P = 0.1 was used to determine significance. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

1999 journal article

Detection of Putative Loci Affecting Milk, Health, and Type Traits in a US Holstein Population Using 70 Microsatellite Markers in a Genome Scan

Journal of Dairy Science, 82(11), 2497–2502.

By: M. Ashwell* & C. Van Tassell*

author keywords: quantitative trait loci; microsatellite markers; type traits; milk production traits
MeSH headings : Alleles; Animals; Breeding; Cattle / genetics; Female; Genotype; Lactation / genetics; Lipids / analysis; Male; Microsatellite Repeats; Milk / chemistry; Milk Proteins / analysis
TL;DR: Quantitative trait loci affecting milk yield, health, and type traits were studied for seven large U.S. Holstein grandsire families using the granddaughter design and microsatellite markers located throughout the genome were selected. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

1999 journal article

Mapping of the bovine growth hormone-releasing hormone receptor (GHRH-R) gene to chromosome 4 by linkage analysis using a novel PCR-RFLP.

Journal of Animal Science, 77(3), 793.

By: E. Connor*, M. Ashwell, S. Kappes* & G. Dahl*

MeSH headings : Animals; Cattle / genetics; Chromosome Mapping / veterinary; Chromosomes; Polymerase Chain Reaction / veterinary; Polymorphism, Restriction Fragment Length; Receptors, LHRH / genetics
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

1999 journal article

RFLP markers in the bovine butyrophilin gene

Animal Genetics, 30(5), 385–386.

By: A. Zegeye*, M. Ashwell*, S. Ogg*, C. Rexroad* & I. Mather*

MeSH headings : Animals; Butyrophilins; Cattle / genetics; Genetic Markers; Membrane Glycoproteins / genetics; Milk Proteins / genetics; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

1998 journal article

Detection of Putative Loci Affecting Conformational Type Traits in an Elite Population of United States Holsteins Using Microsatellite Markers

Journal of Dairy Science, 81(4), 1120–1125.

By: M. Ashwell*, Y. Da*, P. Vanraden*, C. Rexroad* & R. Miller*

MeSH headings : Animals; Cattle / genetics; Chromosome Mapping; Dairying; Female; Hoof and Claw / anatomy & histology; Lactation / genetics; Male; Mammary Glands, Animal / anatomy & histology; Mastitis, Bovine / genetics; Microsatellite Repeats; Multivariate Analysis; Quantitative Trait, Heritable; United States
TL;DR: Quantitative trait loci affecting conformational type traits were studied in seven large grandsire families of US Holsteins using the granddaughter design and 16 microsatellite markers on 10 chromosomes, indicating that one or several quantitative traits affecting traits pertaining to feet and legs might exist on chromosome 9. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

1998 journal article

Detection of Putative Loci Affecting Milk Production and Composition, Health, and Type Traits in a United States Holstein Population

Journal of Dairy Science, 81(12), 3309–3314.

By: M. Ashwell*, Y. Da*, C. Van Tassell*, P. Vanraden*, R. Miller* & C. Rexroad*

author keywords: quantitative trait loci; microsatellite markers; milk yield traits; type traits
MeSH headings : Animals; Cattle / genetics; Chromosome Mapping; Female; Genotype; Health; Lactation / genetics; Lipids / analysis; Microsatellite Repeats; Milk / chemistry; Milk Proteins / analysis; United States
TL;DR: Quantitative trait loci affecting milk yield and composition, health, and type traits were studied for seven large grandsire families of US Holstein using the granddaughter design to identify alleles associated with increases in productive herd life. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

1997 journal article

Detection of loci affecting milk production and health traits in an elite US Holstein population using microsatellite markers

Animal Genetics, 28(3), 216–222.

By: M. Ashwell, C. Rexroad, R. Miller, P. VanRaden* & Y. Da*

author keywords: dairy cattle; microsatellite markers; milk production; quantitative trait loci; somatic cell score
TL;DR: Quantitative trait loci affecting health and milk production traits were studied in seven large half-sib US Holstein families by using the granddaughter design and support the location of a QTL for milk yield and protein yield on chromosome 21. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

1996 journal article

Mapping economic trait loci for somatic cell score in Holstein cattle using microsatellite markers and selective genotyping

Animal Genetics, 27(4), 235–242.

By: M. Ashwell, C. Rexroad, R. Miller & P. VanRaden*

MeSH headings : Alleles; Animals; Cattle / genetics; DNA, Satellite; Female; Genotype; Lactation; Male; Microsatellite Repeats; Milk / metabolism; Models, Genetic; Models, Theoretical; Polymerase Chain Reaction; Semen
TL;DR: Evidence is provided of the usefulness of microsatellite markers and the granddaughter design in the detection of ETL and the most likely position of a somatic cell score ETL lies near marker 513, located on chromosome 23. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 27, 2022

1996 speech

State of the art in animal genome mapping

Presented at the 8th annual mini-symposium of the American Registry of Professional Animal Scientists, Washington, D.C.

By: M. Merrill

Event: 8th annual mini-symposium of the American Registry of Professional Animal Scientists at Washington, D.C

Source: NC State University Libraries
Added: May 27, 2022

1996 journal article

The bovine butyrophilin gene maps to chromsome 23

Animal Genetics, 27(3), 171–173.

By: M. Ashwell, S. Ogg* & I. Mather*

MeSH headings : Animals; Base Sequence; Butyrophilins; Cattle / genetics; Chromosome Mapping; DNA / analysis; Genetic Markers; Hybrid Cells / chemistry; Membrane Glycoproteins / genetics; Mice; Molecular Sequence Data; Polymerase Chain Reaction
TL;DR: Chromosomal assignment of the bovine butyrophilin gene (BTN) was performed by analysis of DNA from somatic hybrid cell lines using the polymerase chain reaction. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 27, 2022

1995 speech

Current techniques used in gene mapping

Presented at the University of Maryland, Animal and Avian Sciences department, College Park, MD.

By: M. Merrill

Event: University of Maryland, Animal and Avian Sciences department at College Park, MD

Source: NC State University Libraries
Added: May 27, 2022

1994 journal article

D10S681, a microsatellite polymorphism near the RET locus

Human Molecular Genetics, 3(4), 677–677.

By: M. Schuster & D. Bowden

MeSH headings : Alleles; Base Sequence; Chromosomes, Human, Pair 10; DNA Primers; DNA, Satellite / genetics; Genetic Markers; Humans; Molecular Sequence Data; Polymorphism, Genetic; Proto-Oncogenes
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

1994 journal article

Development of 124 Sequence-Tagged Sites and Cytogenetic Localization of 217 Cosmids for Human Chromosome 10

Genomics, 22(1), 55–67.

By: C. Zheng*, N. Ma*, T. Dorman, M. Wang*, K. Braunschweiger*, L. Soares*, M. Schuster*, C. Rothschild* ...

MeSH headings : Base Sequence; Chromosome Mapping; Chromosomes, Artificial, Yeast; Chromosomes, Human, Pair 10; Cloning, Molecular; Cosmids; Cytogenetics; DNA Primers / genetics; DNA, Satellite / genetics; Gene Library; Genetic Markers; Humans; Molecular Sequence Data; Oligodeoxyribonucleotides / genetics; Repetitive Sequences, Nucleic Acid; Sequence Tagged Sites
TL;DR: A total of 124 new chromosome 10-specific sequence-tagged sites (STSs) were derived from two sources: (1) DNA sequences obtained from anonymous clones in new libraries enriched for human chromosome 10 inserts, and (2) published sequences of genes and other loci already known to map to chromosome 10. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

1994 journal article

Germline RET mutations in MEN 2A and FMTC and their detection by simple DNA diagnostic tests

Human Molecular Genetics, 3(4), 635–638.

By: F. Xue, H. Yu, L. Maurer, V. Memoll, N. Nutile-McMenemy*, M. Schuster*, D. Bowden*, J. Mao, W. Noll*

MeSH headings : Base Sequence; Carcinoma, Medullary / genetics; Cysteine; DNA Mutational Analysis; Drosophila Proteins; Genetic Carrier Screening; Humans; Molecular Sequence Data; Multiple Endocrine Neoplasia / genetics; Point Mutation; Polymerase Chain Reaction; Proto-Oncogene Mas; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases / genetics; Thyroid Neoplasms / genetics
TL;DR: This study reports seven different germline mutations in the RET proto-oncogene in five of five MEN 2A and five of six FMTC families and developed simple polymerase chain reaction based diagnostic tests for all seven mutations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

1992 journal article

Characterization of radiation/fusion hybrids containing parts of human chromosome 10 and their use in mapping chromosome 10-specific probes

Genomics, 13(1), 25–34.

By: C. Rothschild*, W. Noll*, T. Gravius, M. Schuster*, N. Nutile-McMenemy*, C. Jones*, D. Bowden*

MeSH headings : Chromosome Mapping; Chromosomes, Human, Pair 10; DNA Probes / genetics; Endodeoxyribonucleases / metabolism; Genetic Linkage / genetics; Genetic Markers / genetics; Humans; Hybrid Cells; Nucleic Acid Hybridization; Polymorphism, Restriction Fragment Length
TL;DR: The panel of hybrid cell lines is useful for rapidly localizing unmapped probes and as a source of DNA for the construction of recombinant libraries derived from specific regions of the chromosome. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 20, 2022

Employment

Updated: August 6th, 2014 07:33

2003 - present

North Carolina State University Raleigh, NC, US
Professor Animal Science

1994 - 2003

USDA Agricultural Research Service Washington, DC, US
Research Scientist Gene Evaluation and Mapping Laboratory

Education

Updated: August 6th, 2014 07:32

Wake Forest University Winston-Salem, NC, US
PhD Biochemistry

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