Melanie A Simpson

Impacts of Hyaluronan on Extracellular Vesicle Production and Signaling

Cells.

Mechanisms of coordinating hyaluronan and glycosaminoglycan production by nucleotide sugars

[Review of ]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 322(6), C1201–C1213.

Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer

Oncotarget, 12(19), 1886–1902.

Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase

[Review of ]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 69(1), 13–23.

Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy

NATURE COMMUNICATIONS, 11(1).

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

NATURE COMMUNICATIONS, 10(1).

Hyaluronan pericellular matrix: Particle exclusion assay

In Methods in Molecular Biology (Vol. 1952, pp. 103–110).

Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling

MATRIX BIOLOGY, 78-79, 165–179.

Inhibiting Hexamer Disassembly of Human UDP-Glucose Dehydrogenase by Photoactivated Amino Acid Cross-Linking

Biochemistry, 55(22), 3157–3164.

Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential

Hormones and Cancer, 7(4), 260–271.

Advances in Hyaluronan Biology: Signaling, Regulation, and Disease Mechanisms

International Journal of Cell Biology, 2015.

Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking

Journal of Biological Chemistry, 290(21), 13144–13156.

Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis

Oncogene, 34(43), 5436–5446.

Emerging regulatory paradigms in glutathione metabolism

In Advances in Cancer Research (Vol. 122, pp. 69–101).

Emerging roles for hyaluronidase in cancer metastasis and therapy

In Advances in Cancer Research (Vol. 123, pp. 1–34).

Preface

In Advances in Cancer Research (Vol. 123).

Characterization of IRDye 800CW chlorotoxin as a targeting agent for brain tumors

Analytical Biochemistry, 440(2), 212–219.

Essential role for dnmt1 in the prevention and maintenance of MYC-Induced T-Cell lmphomas

Molecular and Cellular Biology, 33(21), 4321–4333.

Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis

Leukemia, 28(5), 1138–1142.

UDP-glucose Dehydrogenase Activity and Optimal Downstream Cellular Function Require Dynamic Reorganization at the Dimer-Dimer Subunit Interfaces

Journal of Biological Chemistry, 288(49), 35049–35057.

Hyaluronan turnover and hypoxic brown adipocytic differentiation are co-localized with ossification in calcified human aortic valves

Pathology - Research and Practice, 208(11), 642–650.

Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death

Free Radical Biology and Medicine, 53(5), 1181–1191.

Systemic blockade of the hyaluronan receptor for endocytosis prevents lymph node metastasis of prostate cancer

International Journal of Cancer, 131(5), E836–E840.

UDP-glucose Dehydrogenase Polymorphisms from Patients with Congenital Heart Valve Defects Disrupt Enzyme Stability and Quaternary Assembly

Journal of Biological Chemistry, 287(39), 32708–32716.

Enzymatic Defects Underlying Hereditary Glutamate Cysteine Ligase Deficiency Are Mitigated by Association of the Catalytic and Regulatory Subunits

Biochemistry, 50(29), 6508–6517.

Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling

Experimental Cell Research, 317(8), 1214–1225.

Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis

Journal of Clinical Investigation, 122(1), 163–177.

Near-infrared-labeled tetracycline derivative is an effective marker of bone deposition in mice

Analytical Biochemistry, 416(2), 167–173.

Androgen-stimulated UDP-glucose dehydrogenase expression limits prostate androgen availability without impacting hyaluronan levels

Cancer Research, 69(6), 2332–2339.

Hyaluronan Synthesis and Turnover in Prostate Cancer

In Hyaluronan in Cancer Biology (pp. 309–327).

Hyaluronidase Activity of Human Hyal1 Requires Active Site Acidic and Tyrosine Residues

Journal of Biological Chemistry, 284(14), 9433–9442.

Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processing

American Journal of Pathology, 174(3), 1027–1036.

Udp-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer

International Journal of Cancer, 126(2), 315–327.

Characterization and performance of a near-infrared 2-deoxyglucose optical imaging agent for mouse cancer models

Analytical Biochemistry, 384(2), 254–262.

Development of fluorescent contrast agents for optical imaging of mouse disease models

Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 6867.

Hyaluronan and hyaluronidase in genitourinary tumors

Frontiers in Bioscience, 13(15), 5664–5680.

A systematic approach to the development of fluorescent contrast agents for optical imaging of mouse cancer models

Analytical Biochemistry, 367(1), 1–12.

Inducible Hyaluronan Production Reveals Differential Effects on Prostate Tumor Cell Growth and Tumor Angiogenesis

Journal of Biological Chemistry, 282(28), 20561–20572.

Characterization of Human UDP-Glucose Dehydrogenase Reveals Critical Catalytic Roles for Lysine 220 and Aspartate 280

Biochemistry, 46(2), 369–378.

Concurrent expression of hyaluronan biosynthetic and processing enzymes promotes growth and vascularization of prostate tumors in mice

American Journal of Pathology, 169(1), 247–257.

Hyaluronan synthesis and turnover induces metastatic growth

Matrix Biology, 25, S40–S40.

Hyaluronidase expression induces prostate tumor metastasis in an orthotopic mouse model

American Journal of Pathology, 169(4), 1415–1426.

Purification method directly influences effectiveness of an epidermal growth factor-coupled targeting agent for noninvasive tumor detection in mice

Analytical Biochemistry, 361(1), 47–54.

Characterization of Human UDP-glucose Dehydrogenase: CYS-276 is required for the second of two successive oxidations

Journal of Biological Chemistry, 279(22), 23590–23596.

Hyaluronan facilitates invasion of colon carcinoma cells in vitro via interaction with CD44

Cancer Research, 64(13), 4569–4576.

Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms

The Journal of Cell Biology, 165(6), 881–891.

Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth

International Journal of Cancer, 107(5), 739–746.

Inhibition of prostate tumor cell hyaluronan synthesis impairs subcutaneous growth and vascularization in immunocompromised mice

American Journal of Pathology, 161(3), 849–857.

Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells

Journal of Biological Chemistry, 277(12), 10050–10057.

The insulation of genes from external enhancers and silencing chromatin

Proceedings of the National Academy of Sciences of the United States of America, 99(SUPPL. 4), 16433–16437.

Correlation between histone lysine methylation and developmental changes at the chicken β-globin locus

Science, 293(5539), 2453–2455.

Hyaluronan Synthase Elevation in Metastatic Prostate Carcinoma Cells Correlates with Hyaluronan Surface Retention, a Prerequisite for Rapid Adhesion to Bone Marrow Endothelial Cells

Journal of Biological Chemistry, 276(21), 17949–17957.

Melanoma Chondroitin Sulfate Proteoglycan Regulates Matrix Metalloproteinase-dependent Human Melanoma Invasion into Type I Collagen

Journal of Biological Chemistry, 276(22), 18786–18794.

Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci

EMBO Journal, 20(9), 2224–2235.

GATA zinc finger interactions modulate DNA binding and transactivation

Journal of Biological Chemistry, 275(36), 28157–28166.

Structural and functional conservation at the boundaries of the chicken β-globin domain

EMBO Journal, 19(10), 2315–2322.

An insulator element and condensed chromatin region separate the chicken β-globin locus from an independently regulated erythroid-specific folate receptor gene

EMBO Journal, 18(14), 4035–4048.

Biochemical and biophysical analysis of the intracellular lipid binding proteins of adipocytes

Molecular and Cellular Biochemistry, 192(1-2), 33–40.

Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130^cas

Nature Cell Biology, 1(8), 507–513.

Targeted disruption of the adipocyte lipid-binding protein (aP2 protein) gene impairs fat cell lipolysis and increases cellular fatty acid levels

Journal of Lipid Research, 40(5), 967–972. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032895839&partnerID=MN8TOARS

Analysis of a series of phenylalanine 57 mutants of the adipocyte lipid- binding protein

Biochemistry, 37(31), 10980–10986.

Biochemical and crystallographic analyses of a portal mutant of the adipocyte lipid-binding protein

Journal of Biological Chemistry, 272(15), 9793–9801.

Intracellular lipid-binding proteins and their genes

In Annual Review of Nutrition (Vol. 17, pp. 277–303).

Regulation of gene expression in adipose cells by polyunsaturated fatty acids

In Advances in Experimental Medicine and Biology (Vol. 422, pp. 145–156).

Chapter 10 Adipose tissue and lipid metabolism

In New Comprehensive Biochemistry (Vol. 31, pp. 257–281).

Upregulation of keratinocyte lipid binding protein (KLBP) in fat cells of adipocyte lipid binding protein (aP2) knockout mice

FASEB Journal, 10(6). http://www.scopus.com/inward/record.url?eid=2-s2.0-33749131306&partnerID=MN8TOARS