Melanie A Simpson

Impacts of Hyaluronan on Extracellular Vesicle Production and Signaling

Simpson, M. A. (2025, January 18). Cells, Vol. 14.

Phosphorylation of UDP-glucose dehydrogenase increases glycosaminoglycan biosynthesis and promotes tumor cell motility, spheroid growth, and therapeutic resistance

Utz, A. R., Ma, L., Hilovsky, D., Zimmer, B. M., Allego, E., Fluharty, J., … Simpson, M. A. (2025, October 17). Matrix Biology.

Recent insights into the implications of UGDH mutations for human developmental disease

Harwood, H., Zimmer, B. M., Utz, A. R., Barycki, J. J., & Simpson, M. A. (2025, August 28). Biochemical Society Transactions, Vol. 8.

Mechanisms of coordinating hyaluronan and glycosaminoglycan production by nucleotide sugars

Zimmer, B. M., Barycki, J. J., & Simpson, M. A. (2022, April 20). American Journal of Physiology-Cell Physiology, Vol. 322, pp. C1201–C1213.

Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer

Zimmer, B. M., Howell, M. E., Ma, L., Enders, J. R., Lehman, D., Corey, E., … Simpson, M. A. (2021, August 25). Oncotarget, Vol. 12, pp. 1886–1902.

Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase

Zimmer, B. M., Barycki, J. J., & Simpson, M. A. (2020, August 4). Journal of Histochemistry & Cytochemistry, Vol. 69, pp. 13–23.

Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy

Hengel, H., Bosso-Lefèvre, C., Grady, G., Szenker-Ravi, E., Li, H., Pierce, S., … Reversade, B. (2020, January 30). Nature Communications, Vol. 11.

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

Nowialis, P., Lopusna, K., Opavska, J., Haney, S. L., Abraham, A., Sheng, P., … Opavsky, R. (2019, September 26). Nature Communications, Vol. 10.

Hyaluronan Pericellular Matrix: Particle Exclusion Assay

Simpson, M. A. (2019, January 1). Methods in Molecular Biology, Vol. 1952, pp. 103–110.

Molecular Pharmacodynamics-Guided Scheduling of Biologically Effective Doses: A Drug Development Paradigm Applied to MET Tyrosine Kinase Inhibitors

Srivastava, A. K., Hollingshead, M. G., Govindharajulu, J. P., Covey, J. M., Liston, D., Simpson, M. A., … Parchment, R. E. (2018, February 14). Molecular Cancer Therapeutics.

Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling

McAtee, C. O., Booth, C., Elowsky, C., Zhao, L., Payne, J., Fangman, T., … Simpson, M. A. (2018, May 10). Matrix Biology, Vol. 78-79, pp. 165–179.

UGDH germline loss-of-function mutations cause epilepsy and global developmental delay

Bosso-Lefèvre, C., Yu, E., Grady, G., Szenker, E., Jamuar, S. S., Muriello, M., … Reversade, B. (2017, June 6). Mechanisms of Development.

Abstract C41: Altered control of intracellular androgen availability by glucuronidation contributes to loss of androgen dependence in prostate tumor cells

Palmer, M., Ma, L., Romsdahl, T., Wei, Q., Loughman, E., Markham, J., … Simpson, M. A. (2016, July 28). Cancer Research.

Inhibiting Hexamer Disassembly of Human UDP-Glucose Dehydrogenase by Photoactivated Amino Acid Cross-Linking

Biochemistry, 55(22), 3157–3164.

Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential

Hormones and Cancer, 7(4), 260–271.

Advances in Hyaluronan Biology: Signaling, Regulation, and Disease Mechanisms

Simpson, M. A., Motte, C., Sherman, L. S., & Weigel, P. H. (2015, January 1). International Journal of Cell Biology, Vol. 2015.

Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking

Journal of Biological Chemistry, 290(21), 13144–13156.

Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis

Oncogene, 34(43), 5436–5446.

ADVANCES IN CANCER RESEARCH Hyaluronan Signaling and Turnover VOLUME ONE HUNDRED AND TWENTY THREE PREFACE

HYALURONAN SIGNALING AND TURNOVER.

Emerging Regulatory Paradigms in Glutathione Metabolism

Liu, Y., Hyde, A. S., Simpson, M. A., & Barycki, J. J. (2014, January 1). Advances in Cancer Research, Vol. 122, pp. 69–101.

Emerging Roles for Hyaluronidase in Cancer Metastasis and Therapy

McAtee, C. O., Barycki, J. J., & Simpson, M. A. (2014, January 1). Advances in Cancer Research, Vol. 123, pp. 1–34.

Pharmacokinetic and Biodistribution Assessment of a Near Infrared-Labeled PSMA-Specific Small Molecule in Tumor-Bearing Mice

Kovar, J. L., Cheung, L. L., Simpson, M. A., & Olive, D. M. (2014, January 1). Prostate Cancer.

Preface

Simpson, M. A., & Heldin, P. (2014, January 1). Advances in Cancer Research, Vol. 123.

Characterization of IRDye 800CW chlorotoxin as a targeting agent for brain tumors

Analytical Biochemistry, 440(2), 212–219.

Essential Role for Dnmt1 in the Prevention and Maintenance of MYC-Induced T-Cell Lymphomas

Peters, S. L., Hlady, R. A., Opavska, J., Klinkebiel, D., Novakova, S., Smith, L. M., … Opavsky, R. (2013, September 4). Molecular and Cellular Biology, Vol. 33, pp. 4321–4333.

Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis

Leukemia, 28(5), 1138–1142.

UDP-glucose Dehydrogenase Activity and Optimal Downstream Cellular Function Require Dynamic Reorganization at the Dimer-Dimer Subunit Interfaces

Journal of Biological Chemistry, 288(49), 35049–35057.

Abstract 2433: Comparisons between an IRDye 800CW-labeled PSMA-targeted small molecule and antibody for preclinical small animal imaging

Kovar, J. L., Cheung, L. L., Simpson, M. A., & Olive, D. M. (2012, April 1). Cancer Research.

Hyaluronan turnover and hypoxic brown adipocytic differentiation are co-localized with ossification in calcified human aortic valves

Pathology - Research and Practice, 208(11), 642–650.

Impact of hyaluronan turnover on vesicle trafficking and exosome biogenesis

GLYCOBIOLOGY.

Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death

Natarajan, S. K., Zhu, W., Liang, X., Zhang, L., Demers, A. J., Zimmerman, M. C., … Becker, D. F. (2012, July 13). Free Radical Biology and Medicine, Vol. 53, pp. 1181–1191.

Protective role of proline dehydrogenase against oxidative stress

Natarajan, S. K., Zhu, W., Liang, X., Zhang, L., Simpson, M. A., & al⁎, D. F. B. (2012, September 1). Free Radical Biology and Medicine.

Systemic blockade of the hyaluronan receptor for endocytosis prevents lymph node metastasis of prostate cancer

International Journal of Cancer, 131(5), E836–E840.

UDP-glucose Dehydrogenase Polymorphisms from Patients with Congenital Heart Valve Defects Disrupt Enzyme Stability and Quaternary Assembly

Journal of Biological Chemistry, 287(39), 32708–32716.

Use of experimentally controlled quaternary structure mutants to probe regulatorymodes of UDP-glucose dehydrogenase

GLYCOBIOLOGY.

Enzymatic Defects Underlying Hereditary Glutamate Cysteine Ligase Deficiency Are Mitigated by Association of the Catalytic and Regulatory Subunits

Biochemistry, 50(29), 6508–6517.

Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling

Experimental Cell Research, 317(8), 1214–1225.

Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis

Hlady, R. A., Novakova, S., Opavska, J., Klinkebiel, D., Peters, S. L., Bies, J., … Opavsky, R. (2011, December 2). Journal of Clinical Investigation, Vol. 122, pp. 163–177.

Near-infrared-labeled tetracycline derivative is an effective marker of bone deposition in mice

Analytical Biochemistry, 416(2), 167–173.

Abstract LB-200: Regulation of intracellular androgen availability by glucuronidation in prostate tumor cells may contribute to loss of circulating androgen dependence in prostate cancer

Wei, Q., & Simpson, M. A. (2010, April 1). Cancer Research.

Androgen-Stimulated UDP-Glucose Dehydrogenase Expression Limits Prostate Androgen Availability without Impacting Hyaluronan Levels

Wei, Q., Galbenus, R., Raza, A., Cerny, R. L., & Simpson, M. A. (2009, February 25). Cancer Research, Vol. 69, pp. 2332–2339.

Hyaluronan Synthesis and Turnover in Prostate Cancer

Simpson, M. A. (2009, January 1). Elsevier EBooks, pp. 309–327.

Hyaluronidase Activity of Human Hyal1 Requires Active Site Acidic and Tyrosine Residues

Journal of Biological Chemistry, 284(14), 9433–9442.

Integrin-specific near infrared optical imaging agent for tumor-induced angiogenesis detection in mice

CANCER RESEARCH.

Spontaneous Metastasis of Prostate Cancer Is Promoted by Excess Hyaluronan Synthesis and Processing

Bharadwaj, A. G., Kovar, J. L., Loughman, E., Elowsky, C., Oakley, G. G., & Simpson, M. A. (2009, February 14). American Journal Of Pathology, Vol. 174, pp. 1027–1036.

Udp-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer

International Journal of Cancer, 126(2), 315–327.

ANYL 275-Development of fluorescent contrast agents for optical imaging of mouse disease models

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

Characterization and performance of a near-infrared 2-deoxyglucose optical imaging agent for mouse cancer models

Analytical Biochemistry, 384(2), 254–262.

Development of fluorescent contrast agents for optical imaging of mouse disease models

Kovar, J., Simpson, M., Schutz-Geschwender, A., Xu, X., Volcheck, W. M., Sevick-Muraca, E., & Olive, D. M. (2008, February 4). Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE, Vol. 6867.

Hyaluronan and hyaluronidase in genitourinary tumors

Simpson, M. A., & Lokeshwar, V. B. (2008, January 1). Frontiers in Bioscience, Vol. 13, pp. 5664–5680.

Hyaluronan and hyaluronidase in genitourinary tumors

FRONTIERS IN BIOSCIENCE-LANDMARK.

A systematic approach to the development of fluorescent contrast agents for optical imaging of mouse cancer models

Analytical Biochemistry, 367(1), 1–12.

Inducible Hyaluronan Production Reveals Differential Effects on Prostate Tumor Cell Growth and Tumor Angiogenesis

Journal of Biological Chemistry, 282(28), 20561–20572.

Large scale mutation discovery screen identifies functionally variant UGDH alleles in patients with atrioventricular valve defects

CIRCULATION.

Validation of quantitative fluorescence imaging analysis (QFIA) of _-βcatenin in archived prostate tissues for cancer biomarker discovery

JOURNAL OF CLINICAL ONCOLOGY.

Characterization of Human UDP-Glucose Dehydrogenase Reveals Critical Catalytic Roles for Lysine 220 and Aspartate 280

Biochemistry, 46(2), 369–378.

Concurrent Expression of Hyaluronan Biosynthetic and Processing Enzymes Promotes Growth and Vascularization of Prostate Tumors in Mice

Simpson, M. A. (2006, July 1). American Journal Of Pathology, Vol. 169, pp. 247–257.

Hyaluronan synthesis and turnover induces metastatic growth

Matrix Biology, 25, S40–S40.

Hyaluronidase Expression Induces Prostate Tumor Metastasis in an Orthotopic Mouse Model

Kovar, J. L., Johnson, M. A., Volcheck, W. M., Chen, J., & Simpson, M. A. (2006, October 1). American Journal Of Pathology, Vol. 169, pp. 1415–1426.

Progression of prostate cancer is induced by hyaluronan synthesis and turnover

CANCER RESEARCH.

Purification method directly influences effectiveness of an epidermal growth factor-coupled targeting agent for noninvasive tumor detection in mice

Analytical Biochemistry, 361(1), 47–54.

Characterization of Human UDP-glucose Dehydrogenase: CYS-276 is required for the second of two successive oxidations

Journal of Biological Chemistry, 279(22), 23590–23596.

Hyaluronan Facilitates Invasion of Colon Carcinoma Cells in Vitro via Interaction with CD44

Kim, H.-R., Wheeler, M. A., Wilson, C. M., Iida, J., Eng, D., Simpson, M. A., … Bullard, K. M. (2004, July 1). Cancer Research, Vol. 64, pp. 4569–4576.

Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms

The Journal of Cell Biology, 165(6), 881–891.

Hyaluronan synthase‐3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth

Bullard, K. M., Kim, H. R., Wheeler, M. A., Wilson, C. M., Neudauer, C. L., Simpson, M. A., & McCarthy, J. B. (2003, September 12). International Journal of Cancer, Vol. 107, pp. 739–746.

Inhibition of Prostate Tumor Cell Hyaluronan Synthesis Impairs Subcutaneous Growth and Vascularization in Immunocompromised Mice

Simpson, M. A., Wilson, C. M., & McCarthy, J. B. (2002, September 1). American Journal Of Pathology, Vol. 161, pp. 849–857.

Manipulation of Hyaluronan Synthase Expression in Prostate Adenocarcinoma Cells Alters Pericellular Matrix Retention and Adhesion to Bone Marrow Endothelial Cells

Simpson, M. A., Wilson, C. M., Furcht, L. T., Spicer, A. P., Oegema, T. R., & McCarthy, J. B. (2002, March 1). Journal of Biological Chemistry, Vol. 277, pp. 10050–10057.

The insulation of genes from external enhancers and silencing chromatin

Burgess-Beusse, B., Farrell, C., Gaszner, M., Litt, M., Mutskov, V., Recillas-Targa, F., … Felsenfeld, G. (2002, December 10). Proceedings of the National Academy of Sciences, Vol. 99, pp. 16433–16437.

Correlation Between Histone Lysine Methylation and Developmental Changes at the Chicken β-Globin Locus

Litt, M. D., Simpson, M., Gaszner, M., Allis, C. D., & Felsenfeld, G. (2001, September 28). Science, Vol. 293, pp. 2453–2455.

Hyaluronan Synthase Elevation in Metastatic Prostate Carcinoma Cells Correlates with Hyaluronan Surface Retention, a Prerequisite for Rapid Adhesion to Bone Marrow Endothelial Cells

Simpson, M. A., Reiland, J., Burger, S. R., Furcht, L. T., Spicer, A. P., Oegema, T. R., & McCarthy, J. B. (2001, May 1). Journal of Biological Chemistry, Vol. 276, pp. 17949–17957.

Melanoma Chondroitin Sulfate Proteoglycan Regulates Matrix Metalloproteinase-dependent Human Melanoma Invasion into Type I Collagen

Iida, J., Pei, D., Kang, T., Simpson, M. A., Herlyn, M., Furcht, L. T., & McCarthy, J. B. (2001, June 1). Journal of Biological Chemistry, Vol. 276, pp. 18786–18794.

Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci

Litt, M. D., Simpson, M., Recillas-Targa, F., Prioleau, M.-N., & Felsenfeld, G. (2001, May 1). The EMBO Journal, Vol. 20, pp. 2224–2235.