Melanie A Simpson
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Works (28)
Updated: August 8th, 2023 21:18
2022 review
Mechanisms of coordinating hyaluronan and glycosaminoglycan production by nucleotide sugars
[Review of ]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 322(6), C1201–C1213.
author keywords: hexosamine biosynthesis pathway; hyaluronan; nucleotide sugars; UDP-glucuronate; UDP-N-acetylglucosamine
MeSH headings : Glycosaminoglycans; Hyaluronan Synthases / genetics; Hyaluronic Acid / metabolism; Nucleotides; Sugars; Uridine Diphosphate N-Acetylglucosamine / metabolism
Source: Web Of Science
Added: June 27, 2022
2021 review
Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase
[Review of ]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 69(1), 13–23.
author keywords: developmental disorders; extracellular matrix; glucuronidation; glycosaminoglycan; hyaluronan; nucleotide sugars; post-translational modifications; proteoglycan; UDP-glucuronate
MeSH headings : Allosteric Regulation; Animals; Biosynthetic Pathways; Humans; Models, Molecular; Neoplasms / metabolism; Protein Processing, Post-Translational; Proteoglycans / metabolism; Sugars / metabolism; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Uridine Diphosphate Glucose Dehydrogenase / metabolism
journals.sagepub.com (publisher PDF)
Source: Web Of Science
Added: August 24, 2020
2020 journal article
Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy
NATURE COMMUNICATIONS, 11(1).
MeSH headings : Adolescent; Alleles; Animals; Child; Child, Preschool; Epilepsy / genetics; Female; Genes, Recessive; Humans; Infant; Kinetics; Loss of Function Mutation / genetics; Male; Organoids / pathology; Oxidoreductases / chemistry; Oxidoreductases / genetics; Pedigree; Protein Domains; Syndrome; Uridine Diphosphate Glucose Dehydrogenase / genetics; Zebrafish
Source: Web Of Science
Added: July 20, 2020
2019 journal article
Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions
NATURE COMMUNICATIONS, 10.
MeSH headings : Animals; Biocatalysis; DNA (Cytosine-5-)-Methyltransferases / genetics; DNA (Cytosine-5-)-Methyltransferases / metabolism; DNA Methylation; Embryonic Development / genetics; Female; Gene Expression Regulation, Developmental; HEK293 Cells; Hedgehog Proteins / genetics; Humans; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Signal Transduction / genetics; Wnt Proteins / genetics
Source: Web Of Science
Added: October 21, 2019
2019 journal article
Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling
MATRIX BIOLOGY, 78-79, 165–179.
author keywords: Hyaluronan; Hyaluronidase; Prostate cancer; Cell motility; Exosomes; Stromal-epithelial crosstalk
MeSH headings : Autophagosomes / metabolism; Cell Adhesion; Cell Communication; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Enzyme Activation; Exosomes / metabolism; Focal Adhesion Kinase 1 / metabolism; Gene Expression Regulation, Neoplastic; Humans; Hyaluronoglucosaminidase / metabolism; Integrins / metabolism; Male; Microtubule-Associated Proteins / metabolism; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology; Signal Transduction; Stromal Cells / cytology; Stromal Cells / metabolism; Stromal Cells / pathology; Up-Regulation
Source: Web Of Science
Added: June 17, 2019
2016 journal article
Inhibiting Hexamer Disassembly of Human UDP-Glucose Dehydrogenase by Photoactivated Amino Acid Cross-Linking
Biochemistry, 55(22), 3157–3164.
MeSH headings : Amino Acids / chemistry; Amino Acids / radiation effects; Catalysis; Cross-Linking Reagents; Humans; Kinetics; Light; Models, Molecular; Oxidation-Reduction; Photochemical Processes; Protein Conformation; Protein Multimerization / radiation effects; Uridine Diphosphate Glucose / metabolism; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Uridine Diphosphate Glucose Dehydrogenase / metabolism
Source: Crossref
Added: February 24, 2020
2016 journal article
Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential
Hormones and Cancer, 7(4), 260–271.
author keywords: Prostate cancer; Castration resistance; Dihydrotestosterone; Detoxification; LNCaP
MeSH headings : Androgens / pharmacology; Cell Line, Tumor; Gene Expression Regulation, Neoplastic / drug effects; Glucuronides / metabolism; Glucuronosyltransferase / metabolism; Humans; Kallikreins / genetics; Kallikreins / metabolism; Male; Minor Histocompatibility Antigens / metabolism; Models, Biological; Promoter Regions, Genetic; Prostate-Specific Antigen / genetics; Prostate-Specific Antigen / metabolism; Prostatic Neoplasms / genetics; Prostatic Neoplasms / metabolism; Prostatic Neoplasms, Castration-Resistant / genetics; Prostatic Neoplasms, Castration-Resistant / metabolism; Receptors, Androgen / metabolism; Uridine Diphosphate Glucose Dehydrogenase / metabolism
Source: Crossref
Added: February 24, 2020
2015 journal article
Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking
Journal of Biological Chemistry, 290(21), 13144–13156.
MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Antigens, Neoplasm / metabolism; Apoptosis; Blotting, Western; Cell Movement; Cell Proliferation; Endocytosis / physiology; Endosomes / metabolism; Histone Acetyltransferases / metabolism; Humans; Hyaluronic Acid / metabolism; Hyaluronoglucosaminidase / metabolism; Male; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology; Protein Transport; Subcellular Fractions; Transferrin / metabolism; Transport Vesicles / metabolism; Tumor Cells, Cultured
Source: Crossref
Added: February 24, 2020
2015 journal article
Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis
Oncogene, 34(43), 5436–5446.
MeSH headings : Animals; Carcinogenesis / genetics; Cell Proliferation / genetics; DNA / genetics; DNA (Cytosine-5-)-Methyltransferases / genetics; DNA Methylation / genetics; DNA Methyltransferase 3A; Disease Models, Animal; Disease Progression; Lymphoma, T-Cell / genetics; Lymphoma, T-Cell / pathology; Mice; Promoter Regions, Genetic / genetics; Proto-Oncogene Proteins c-myc / genetics; Transcriptome / genetics; Up-Regulation / genetics
Source: Crossref
Added: December 21, 2020
2014 journal article
Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis
Leukemia, 28(5), 1138–1142.
MeSH headings : Animals; DNA (Cytosine-5-)-Methyltransferases / metabolism; DNA Methyltransferase 3A; Genes, Tumor Suppressor; Lymphoma / enzymology; Lymphoma / pathology; Lymphopoiesis; Mice
Source: Crossref
Added: December 21, 2020
2013 journal article
Characterization of IRDye 800CW chlorotoxin as a targeting agent for brain tumors
Analytical Biochemistry, 440(2), 212–219.
author keywords: Medulloblastoma; IRDye 800CW; Chlorotoxin; In vivo imaging; Blood-brain barrier; ND2:SmoA1 homozygous transgenic mouse
MeSH headings : Animals; Benzenesulfonates / chemistry; Blood-Brain Barrier / metabolism; Cell Line, Tumor; Cerebellar Neoplasms / diagnosis; Cerebellar Neoplasms / metabolism; Cerebellar Neoplasms / pathology; Humans; Indoles / chemistry; Matrix Metalloproteinase 2 / metabolism; Medulloblastoma / diagnosis; Medulloblastoma / metabolism; Medulloblastoma / pathology; Mice; Scorpion Venoms / chemistry; Scorpion Venoms / metabolism
Source: Crossref
Added: December 21, 2020
2013 journal article
UDP-glucose Dehydrogenase Activity and Optimal Downstream Cellular Function Require Dynamic Reorganization at the Dimer-Dimer Subunit Interfaces
Journal of Biological Chemistry, 288(49), 35049–35057.
author keywords: Dehydrogenase; Enzyme Catalysis; Glycobiology; Hyaluronate; Prostate Cancer; Protein Conformation; Protein Dynamics; Cardiac Defects; Human UGDH; Hyaluronan
MeSH headings : Amino Acid Substitution; Enzyme Stability; HEK293 Cells; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Protein Interaction Domains and Motifs; Protein Multimerization; Protein Structure, Quaternary; Protein Subunits; Proteolysis; Thermodynamics; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Uridine Diphosphate Glucose Dehydrogenase / genetics; Uridine Diphosphate Glucose Dehydrogenase / metabolism
Source: Crossref
Added: August 28, 2020
2012 journal article
Hyaluronan turnover and hypoxic brown adipocytic differentiation are co-localized with ossification in calcified human aortic valves
Pathology - Research and Practice, 208(11), 642–650.
author keywords: Brown adipocytes; Hyaluronan; Hypoxia; Calcification; Aortic valve
MeSH headings : Adipocytes, Brown / metabolism; Adipocytes, Brown / pathology; Aged; Aortic Valve / metabolism; Aortic Valve / pathology; Aortic Valve / surgery; Aortic Valve Stenosis / metabolism; Aortic Valve Stenosis / pathology; Biomarkers / metabolism; Calcinosis / etiology; Calcinosis / metabolism; Calcinosis / pathology; Cell Adhesion Molecules / metabolism; Cell Differentiation; Female; Glucuronosyltransferase / metabolism; Homeostasis / physiology; Humans; Hyaluronan Synthases; Hyaluronic Acid / metabolism; Hyaluronoglucosaminidase / metabolism; Hypoxia / metabolism; Male; Ossification, Heterotopic / metabolism; Ossification, Heterotopic / pathology
Source: Crossref
Added: January 30, 2021
2012 journal article
Systemic blockade of the hyaluronan receptor for endocytosis prevents lymph node metastasis of prostate cancer
International Journal of Cancer, 131(5), E836–E840.
author keywords: prostate cancer; hyaluronan; metastasis; HARE; Stab2; Stabilin 2; mouse orthotopic model
MeSH headings : Adenocarcinoma / immunology; Adenocarcinoma / prevention & control; Adenocarcinoma / secondary; Animals; Antibodies, Monoclonal / therapeutic use; Cell Adhesion Molecules, Neuronal / antagonists & inhibitors; Cell Adhesion Molecules, Neuronal / immunology; Endocytosis; Humans; Hyaluronic Acid / metabolism; Lymph Nodes / drug effects; Lymph Nodes / metabolism; Lymph Nodes / pathology; Lymphatic Metastasis; Male; Mice; Mice, Inbred NOD; Mice, SCID; Prostatic Neoplasms / immunology; Prostatic Neoplasms / pathology; Prostatic Neoplasms / prevention & control; Tumor Cells, Cultured
Source: Crossref
Added: January 30, 2021
2012 journal article
UDP-glucose Dehydrogenase Polymorphisms from Patients with Congenital Heart Valve Defects Disrupt Enzyme Stability and Quaternary Assembly
Journal of Biological Chemistry, 287(39), 32708–32716.
MeSH headings : Amino Acid Substitution; Animals; Animals, Genetically Modified / embryology; Animals, Genetically Modified / genetics; Enzyme Stability / genetics; Escherichia coli; Heart Defects, Congenital / embryology; Heart Defects, Congenital / enzymology; Heart Defects, Congenital / genetics; Heart Valve Diseases / embryology; Heart Valve Diseases / enzymology; Heart Valve Diseases / genetics; Heart Valves / embryology; Heart Valves / enzymology; Muscle Proteins / genetics; Muscle Proteins / metabolism; Mutation, Missense; Polymorphism, Genetic; Protein Structure, Quaternary; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Uridine Diphosphate Glucose Dehydrogenase; Zebrafish / embryology; Zebrafish / genetics; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
Source: Crossref
Added: August 28, 2020
2011 journal article
Enzymatic Defects Underlying Hereditary Glutamate Cysteine Ligase Deficiency Are Mitigated by Association of the Catalytic and Regulatory Subunits
Biochemistry, 50(29), 6508–6517.
MeSH headings : Animals; Catalytic Domain; Enzyme Stability; Glutamate-Cysteine Ligase / chemistry; Glutamate-Cysteine Ligase / deficiency; Glutamate-Cysteine Ligase / metabolism; Glutathione / biosynthesis; Homozygote; Humans; Kinetics; Mice; Models, Biological; Mutant Proteins / metabolism; Mutation / genetics; Protein Binding; Protein Structure, Secondary; Recombinant Proteins / metabolism; Saccharomyces cerevisiae / metabolism; Structural Homology, Protein; Temperature
Source: Crossref
Added: August 28, 2020
2011 journal article
Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling
Experimental Cell Research, 317(8), 1214–1225.
author keywords: Hyaluronan; Prostate cancer; Cadherin; Integrin; Cell adhesion; Cell cycle
MeSH headings : Antigens, CD / genetics; Antigens, CD / metabolism; Cadherins / genetics; Cadherins / metabolism; Cell Cycle / physiology; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases / antagonists & inhibitors; Cyclin-Dependent Kinases / metabolism; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases / metabolism; Focal Adhesion Protein-Tyrosine Kinases / antagonists & inhibitors; Focal Adhesion Protein-Tyrosine Kinases / metabolism; Humans; Hyaluronic Acid / metabolism; Male; Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinase Kinases / metabolism; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology; Proto-Oncogene Proteins c-akt / antagonists & inhibitors; Proto-Oncogene Proteins c-akt / metabolism; Receptors, Growth Factor / genetics; Receptors, Growth Factor / metabolism; Signal Transduction / physiology; beta Catenin / genetics; beta Catenin / metabolism
Source: Crossref
Added: January 30, 2021
2011 journal article
Near-infrared-labeled tetracycline derivative is an effective marker of bone deposition in mice
Analytical Biochemistry, 416(2), 167–173.
author keywords: IRDye 800CW; Tetracycline derivative; Near-infrared; Molecular imaging; Whole animal imaging; Fluorescence microscopy; Immunofluorescent assay; Mineralization
MeSH headings : Animals; Biomarkers / analysis; Bone Remodeling; Calcification, Physiologic; Cell Line; Disease Models, Animal; Fluoresceins / chemistry; Indoles / chemistry; Mice; Mice, Nude; Microscopy, Fluorescence / methods; Osteoporosis / metabolism; Spectroscopy, Near-Infrared / methods; Tetracycline / analysis; Tetracycline / chemistry; Whole Body Imaging
Source: Crossref
Added: January 30, 2021
2010 journal article
Udp-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer
International Journal of Cancer, 126(2), 315–327.
author keywords: UGDH; biomarker; prostate cancer; tissue proteomics; field disease/effect
MeSH headings : Aged; Biomarkers, Tumor / metabolism; Biopsy; Blotting, Western; Cell Line, Tumor; Humans; Male; Microscopy, Fluorescence; Middle Aged; Prostate / enzymology; Prostate / pathology; Prostatic Neoplasms / diagnosis; Prostatic Neoplasms / enzymology; Prostatic Neoplasms / pathology; Protein Array Analysis / methods; Sensitivity and Specificity; Uridine Diphosphate Glucose Dehydrogenase / metabolism
Source: Crossref
Added: January 30, 2021
2009 journal article
Characterization and performance of a near-infrared 2-deoxyglucose optical imaging agent for mouse cancer models
Analytical Biochemistry, 384(2), 254–262.
author keywords: IRDye 800CW; 2-Deoxyglucose; Near infrared; Molecular imaging; Immunofluorescent assay; Fluorescence microscopy; Whole animal imaging
MeSH headings : Animals; Cell Line, Tumor; Deoxyglucose / analogs & derivatives; Deoxyglucose / chemistry; Deoxyglucose / metabolism; Diagnostic Imaging; Fluorescent Dyes / chemistry; Fluoroimmunoassay; Humans; Indoles / chemistry; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasms / diagnosis; Neoplasms / metabolism; Spectroscopy, Near-Infrared; Xenograft Model Antitumor Assays
Source: Crossref
Added: January 30, 2021
2009 journal article
Hyaluronidase Activity of Human Hyal1 Requires Active Site Acidic and Tyrosine Residues
Journal of Biological Chemistry, 284(14), 9433–9442.
MeSH headings : Acids / chemistry; Biocatalysis; Catalytic Domain; Cell Line; Crystallography, X-Ray; Disulfides / chemistry; Glycosylation; Humans; Hyaluronoglucosaminidase / chemistry; Hyaluronoglucosaminidase / genetics; Hyaluronoglucosaminidase / metabolism; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutation / genetics; Oligosaccharides / chemistry; Oligosaccharides / metabolism; Protein Structure, Tertiary; Tyrosine / genetics; Tyrosine / metabolism
Source: Crossref
Added: August 28, 2020
2007 journal article
A systematic approach to the development of fluorescent contrast agents for optical imaging of mouse cancer models
Analytical Biochemistry, 367(1), 1–12.
MeSH headings : Animals; Contrast Media; Fluorescence; Fluorescent Dyes; Ligands; Membrane Proteins / metabolism; Mice; Molecular Probe Techniques; Neoplasm Proteins / metabolism; Neoplasms, Experimental / diagnosis; Neoplasms, Experimental / metabolism
Source: Crossref
Added: January 30, 2021
2007 journal article
Characterization of Human UDP-Glucose Dehydrogenase Reveals Critical Catalytic Roles for Lysine 220 and Aspartate 280
Biochemistry, 46(2), 369–378.
MeSH headings : Amino Acid Substitution; Aspartic Acid / chemistry; Catalytic Domain / genetics; Dimerization; Humans; In Vitro Techniques; Kinetics; Lysine / chemistry; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Quaternary; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Uridine Diphosphate Glucose Dehydrogenase / genetics; Uridine Diphosphate Glucose Dehydrogenase / metabolism
Source: Crossref
Added: August 28, 2020
2007 journal article
Inducible Hyaluronan Production Reveals Differential Effects on Prostate Tumor Cell Growth and Tumor Angiogenesis
Journal of Biological Chemistry, 282(28), 20561–20572.
MeSH headings : Cell Line, Tumor; Gene Expression Regulation, Enzymologic / genetics; Gene Expression Regulation, Neoplastic / genetics; Glucuronosyltransferase / biosynthesis; Glucuronosyltransferase / genetics; Humans; Hyaluronan Synthases; Hyaluronic Acid / metabolism; Hyaluronoglucosaminidase / biosynthesis; Hyaluronoglucosaminidase / genetics; Male; Neoplasm Invasiveness / genetics; Neoplasm Invasiveness / pathology; Neoplasm Proteins / biosynthesis; Neoplasm Proteins / genetics; Neovascularization, Pathologic / enzymology; Neovascularization, Pathologic / genetics; Neovascularization, Pathologic / pathology; Prostatic Neoplasms / enzymology; Prostatic Neoplasms / genetics; Prostatic Neoplasms / pathology
Source: Crossref
Added: January 30, 2021
2007 journal article
Purification method directly influences effectiveness of an epidermal growth factor-coupled targeting agent for noninvasive tumor detection in mice
Analytical Biochemistry, 361(1), 47–54.
author keywords: EGF receptor; IRDye 800CW EGF; in-cell western assay; binding affinity; noninvasive; whole animal imaging
MeSH headings : Animals; Carcinoma, Squamous Cell / diagnosis; Carcinoma, Squamous Cell / pathology; Cell Line, Tumor; Chromatography, Gel; Chromatography, High Pressure Liquid; Coloring Agents; Epidermal Growth Factor; ErbB Receptors; Humans; Indicators and Reagents; Mice; Mice, Nude; Mice, SCID; Sensitivity and Specificity; Spectrometry, Fluorescence / methods; Transplantation, Heterologous
Source: Crossref
Added: January 30, 2021
2006 journal article
Hyaluronan synthesis and turnover induces metastatic growth
Matrix Biology, 25, S40–S40.
Source: Crossref
Added: January 30, 2021
2004 journal article
Characterization of Human UDP-glucose Dehydrogenase: CYS-276 is required for the second of two successive oxidations
Journal of Biological Chemistry, 279(22), 23590–23596.
MeSH headings : Binding Sites; Catalytic Domain / genetics; Cysteine; Humans; Lysine; Oxidation-Reduction; Protein Conformation; Streptococcus pyogenes; Structure-Activity Relationship; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Uridine Diphosphate Glucose Dehydrogenase / genetics; Uridine Diphosphate Glucose Dehydrogenase / metabolism
Source: Crossref
Added: August 28, 2020
2004 journal article
Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms
The Journal of Cell Biology, 165(6), 881–891.
author keywords: melanoma chondroitin sulfate proteoglycan; FAK; integrin; ERK1/2; cell spreading
MeSH headings : Amino Acid Sequence; Cell Line, Tumor; Chondroitin Sulfate Proteoglycans / chemistry; Chondroitin Sulfate Proteoglycans / genetics; Chondroitin Sulfate Proteoglycans / pharmacology; Enzyme Activation / drug effects; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Melanoma; Membrane Proteins / chemistry; Membrane Proteins / genetics; Membrane Proteins / pharmacology; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; Protein-Tyrosine Kinases / metabolism; Sequence Alignment; Sequence Homology, Amino Acid
Source: Crossref
Added: January 30, 2021
