Melanie A Simpson

Mechanisms of coordinating hyaluronan and glycosaminoglycan production by nucleotide sugars

[Review of ]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 322(6), C1201–C1213.

Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase

[Review of ]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 69(1), 13–23.

Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy

NATURE COMMUNICATIONS, 11(1).

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

NATURE COMMUNICATIONS, 10.

Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling

MATRIX BIOLOGY, 78-79, 165–179.

Inhibiting Hexamer Disassembly of Human UDP-Glucose Dehydrogenase by Photoactivated Amino Acid Cross-Linking

Biochemistry, 55(22), 3157–3164.

Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential

Hormones and Cancer, 7(4), 260–271.

Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking

Journal of Biological Chemistry, 290(21), 13144–13156.

Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis

Oncogene, 34(43), 5436–5446.

Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis

Leukemia, 28(5), 1138–1142.

Characterization of IRDye 800CW chlorotoxin as a targeting agent for brain tumors

Analytical Biochemistry, 440(2), 212–219.

UDP-glucose Dehydrogenase Activity and Optimal Downstream Cellular Function Require Dynamic Reorganization at the Dimer-Dimer Subunit Interfaces

Journal of Biological Chemistry, 288(49), 35049–35057.

Hyaluronan turnover and hypoxic brown adipocytic differentiation are co-localized with ossification in calcified human aortic valves

Pathology - Research and Practice, 208(11), 642–650.

Systemic blockade of the hyaluronan receptor for endocytosis prevents lymph node metastasis of prostate cancer

International Journal of Cancer, 131(5), E836–E840.

UDP-glucose Dehydrogenase Polymorphisms from Patients with Congenital Heart Valve Defects Disrupt Enzyme Stability and Quaternary Assembly

Journal of Biological Chemistry, 287(39), 32708–32716.

Enzymatic Defects Underlying Hereditary Glutamate Cysteine Ligase Deficiency Are Mitigated by Association of the Catalytic and Regulatory Subunits

Biochemistry, 50(29), 6508–6517.

Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling

Experimental Cell Research, 317(8), 1214–1225.

Near-infrared-labeled tetracycline derivative is an effective marker of bone deposition in mice

Analytical Biochemistry, 416(2), 167–173.

Udp-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer

International Journal of Cancer, 126(2), 315–327.

Characterization and performance of a near-infrared 2-deoxyglucose optical imaging agent for mouse cancer models

Analytical Biochemistry, 384(2), 254–262.

Hyaluronidase Activity of Human Hyal1 Requires Active Site Acidic and Tyrosine Residues

Journal of Biological Chemistry, 284(14), 9433–9442.

A systematic approach to the development of fluorescent contrast agents for optical imaging of mouse cancer models

Analytical Biochemistry, 367(1), 1–12.

Characterization of Human UDP-Glucose Dehydrogenase Reveals Critical Catalytic Roles for Lysine 220 and Aspartate 280

Biochemistry, 46(2), 369–378.

Inducible Hyaluronan Production Reveals Differential Effects on Prostate Tumor Cell Growth and Tumor Angiogenesis

Journal of Biological Chemistry, 282(28), 20561–20572.

Purification method directly influences effectiveness of an epidermal growth factor-coupled targeting agent for noninvasive tumor detection in mice

Analytical Biochemistry, 361(1), 47–54.

Hyaluronan synthesis and turnover induces metastatic growth

Matrix Biology, 25, S40–S40.

Characterization of Human UDP-glucose Dehydrogenase: CYS-276 is required for the second of two successive oxidations

Journal of Biological Chemistry, 279(22), 23590–23596.

Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms

The Journal of Cell Biology, 165(6), 881–891.