Works (28)

Updated: April 11th, 2023 10:13

2022 review

Mechanisms of coordinating hyaluronan and glycosaminoglycan production by nucleotide sugars

[Review of ]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 322(6), C1201–C1213.

By: B. Zimmer, J. Barycki n & M. Simpson

author keywords: hexosamine biosynthesis pathway; hyaluronan; nucleotide sugars; UDP-glucuronate; UDP-N-acetylglucosamine
Source: Web Of Science
Added: June 27, 2022

2021 review

Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase

[Review of ]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 69(1), 13–23.

By: B. Zimmer, J. Barycki n & M. Simpson

author keywords: developmental disorders; extracellular matrix; glucuronidation; glycosaminoglycan; hyaluronan; nucleotide sugars; post-translational modifications; proteoglycan; UDP-glucuronate
Source: Web Of Science
Added: August 24, 2020

2020 journal article

Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy

NATURE COMMUNICATIONS, 11(1).

By: H. Hengel*, C. Bosso-Lefevre*, G. Grady n, E. Szenker-Ravi*, H. Li*, S. Pierce*, E. Lebigot, T. Tan* ...

Source: Web Of Science
Added: July 20, 2020

2019 journal article

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

NATURE COMMUNICATIONS, 10.

By: P. Nowialis*, K. Lopusna*, J. Opayska, S. Haney*, A. Abraham*, P. Sheng*, A. Riva*, A. Natarajan* ...

Source: Web Of Science
Added: October 21, 2019

2019 journal article

Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling

MATRIX BIOLOGY, 78-79, 165–179.

By: C. McAtee*, C. Booth*, C. Elowsky*, L. Zhao*, J. Payne*, T. Fangman*, S. Caplan*, M. Henry*, M. Simpson

author keywords: Hyaluronan; Hyaluronidase; Prostate cancer; Cell motility; Exosomes; Stromal-epithelial crosstalk
Source: Web Of Science
Added: June 17, 2019

2016 journal article

Inhibiting Hexamer Disassembly of Human UDP-Glucose Dehydrogenase by Photoactivated Amino Acid Cross-Linking

Biochemistry, 55(22), 3157–3164.

By: G. Grady*, A. Thelen*, J. Albers*, T. Ju*, J. Guo*, J. Barycki*, M. Simpson

Source: Crossref
Added: February 24, 2020

2016 journal article

Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential

Hormones and Cancer, 7(4), 260–271.

By: B. Zimmer, M. Howell, Q. Wei, L. Ma, T. Romsdahl, E. Loughman, J. Markham, J. Seravalli, J. Barycki, M. Simpson

author keywords: Prostate cancer; Castration resistance; Dihydrotestosterone; Detoxification; LNCaP
Source: Crossref
Added: February 24, 2020

2015 journal article

Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking

Journal of Biological Chemistry, 290(21), 13144–13156.

By: C. McAtee*, A. Berkebile*, C. Elowsky*, T. Fangman*, J. Barycki*, J. Wahl*, O. Khalimonchuk*, N. Naslavsky*, S. Caplan*, M. Simpson

Source: Crossref
Added: February 24, 2020

2015 journal article

Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis

Oncogene, 34(43), 5436–5446.

By: S. Haney*, R. Hlady*, J. Opavska*, D. Klinkebiel*, S. Pirruccello*, S. Dutta*, K. Datta*, M. Simpson, L. Wu*, R. Opavsky*

Source: Crossref
Added: December 21, 2020

2014 journal article

Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis

Leukemia, 28(5), 1138–1142.

By: S. Peters, R. Hlady*, J. Opavska*, D. Klinkebiel*, S. Pirruccello*, G. Talmon*, J. Sharp*, L. Wu* ...

Source: Crossref
Added: December 21, 2020

2013 journal article

Characterization of IRDye 800CW chlorotoxin as a targeting agent for brain tumors

Analytical Biochemistry, 440(2), 212–219.

By: J. Kovar*, E. Curtis*, S. Othman*, M. Simpson & D. Michael Olive

author keywords: Medulloblastoma; IRDye 800CW; Chlorotoxin; In vivo imaging; Blood-brain barrier; ND2:SmoA1 homozygous transgenic mouse
Source: Crossref
Added: December 21, 2020

2013 journal article

UDP-glucose Dehydrogenase Activity and Optimal Downstream Cellular Function Require Dynamic Reorganization at the Dimer-Dimer Subunit Interfaces

Journal of Biological Chemistry, 288(49), 35049–35057.

By: A. Hyde, A. Thelen, J. Barycki* & M. Simpson

author keywords: Dehydrogenase; Enzyme Catalysis; Glycobiology; Hyaluronate; Prostate Cancer; Protein Conformation; Protein Dynamics; Cardiac Defects; Human UGDH; Hyaluronan
Source: Crossref
Added: August 28, 2020

2012 journal article

Hyaluronan turnover and hypoxic brown adipocytic differentiation are co-localized with ossification in calcified human aortic valves

Pathology - Research and Practice, 208(11), 642–650.

By: E. Stephens*, J. Saltarrelli Jr, L. Balaoing*, L. Baggett*, I. Nandi*, K. Anderson*, J. Morrisett*, M. Reardon* ...

author keywords: Brown adipocytes; Hyaluronan; Hypoxia; Calcification; Aortic valve
Source: Crossref
Added: January 30, 2021

2012 journal article

Systemic blockade of the hyaluronan receptor for endocytosis prevents lymph node metastasis of prostate cancer

International Journal of Cancer, 131(5), E836–E840.

By: M. Simpson, J. Weigel & P. Weigel

author keywords: prostate cancer; hyaluronan; metastasis; HARE; Stab2; Stabilin 2; mouse orthotopic model
Source: Crossref
Added: January 30, 2021

2012 journal article

UDP-glucose Dehydrogenase Polymorphisms from Patients with Congenital Heart Valve Defects Disrupt Enzyme Stability and Quaternary Assembly

Journal of Biological Chemistry, 287(39), 32708–32716.

By: A. Hyde*, E. Farmer*, K. Easley*, K. van Lammeren*, V. Christoffels*, J. Barycki*, J. Bakkers*, M. Simpson

Source: Crossref
Added: August 28, 2020

2011 journal article

Enzymatic Defects Underlying Hereditary Glutamate Cysteine Ligase Deficiency Are Mitigated by Association of the Catalytic and Regulatory Subunits

Biochemistry, 50(29), 6508–6517.

By: M. Willis*, Y. Liu*, E. Biterova*, M. Simpson, H. Kim*, J. Lee*, J. Barycki*

Source: Crossref
Added: August 28, 2020

2011 journal article

Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling

Experimental Cell Research, 317(8), 1214–1225.

By: A. Bharadwaj*, N. Goodrich*, C. McAtee*, K. Haferbier*, G. Oakley*, J. Wahl*, M. Simpson

author keywords: Hyaluronan; Prostate cancer; Cadherin; Integrin; Cell adhesion; Cell cycle
Source: Crossref
Added: January 30, 2021

2011 journal article

Near-infrared-labeled tetracycline derivative is an effective marker of bone deposition in mice

Analytical Biochemistry, 416(2), 167–173.

By: J. Kovar*, X. Xu*, D. Draney*, A. Cupp*, M. Simpson & D. Olive*

author keywords: IRDye 800CW; Tetracycline derivative; Near-infrared; Molecular imaging; Whole animal imaging; Fluorescence microscopy; Immunofluorescent assay; Mineralization
Source: Crossref
Added: January 30, 2021

2010 journal article

Udp-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer

International Journal of Cancer, 126(2), 315–327.

By: D. Huang*, G. Casale*, J. Tian*, S. Lele*, V. Pisarev*, M. Simpson, G. Hemstreet*

author keywords: UGDH; biomarker; prostate cancer; tissue proteomics; field disease/effect
Source: Crossref
Added: January 30, 2021

2009 journal article

Characterization and performance of a near-infrared 2-deoxyglucose optical imaging agent for mouse cancer models

Analytical Biochemistry, 384(2), 254–262.

By: J. Kovar*, W. Volcheck*, E. Sevick-Muraca*, M. Simpson & D. Olive*

author keywords: IRDye 800CW; 2-Deoxyglucose; Near infrared; Molecular imaging; Immunofluorescent assay; Fluorescence microscopy; Whole animal imaging
Source: Crossref
Added: January 30, 2021

2009 journal article

Hyaluronidase Activity of Human Hyal1 Requires Active Site Acidic and Tyrosine Residues

Journal of Biological Chemistry, 284(14), 9433–9442.

By: L. Zhang*, A. Bharadwaj*, A. Casper*, J. Barkley*, J. Barycki* & M. Simpson

Source: Crossref
Added: August 28, 2020

2007 journal article

A systematic approach to the development of fluorescent contrast agents for optical imaging of mouse cancer models

Analytical Biochemistry, 367(1), 1–12.

By: J. Kovar*, M. Simpson, A. Schutz-Geschwender* & D. Olive*

Source: Crossref
Added: January 30, 2021

2007 journal article

Characterization of Human UDP-Glucose Dehydrogenase Reveals Critical Catalytic Roles for Lysine 220 and Aspartate 280

Biochemistry, 46(2), 369–378.

By: K. Easley*, B. Sommer*, G. Boanca*, J. Barycki* & M. Simpson

Source: Crossref
Added: August 28, 2020

2007 journal article

Inducible Hyaluronan Production Reveals Differential Effects on Prostate Tumor Cell Growth and Tumor Angiogenesis

Journal of Biological Chemistry, 282(28), 20561–20572.

By: A. Bharadwaj*, K. Rector* & M. Simpson

Source: Crossref
Added: January 30, 2021

2007 journal article

Purification method directly influences effectiveness of an epidermal growth factor-coupled targeting agent for noninvasive tumor detection in mice

Analytical Biochemistry, 361(1), 47–54.

By: J. Kovar, W. Volcheck, J. Chen & M. Simpson

author keywords: EGF receptor; IRDye 800CW EGF; in-cell western assay; binding affinity; noninvasive; whole animal imaging
Source: Crossref
Added: January 30, 2021

2006 journal article

Hyaluronan synthesis and turnover induces metastatic growth

Matrix Biology, 25, S40–S40.

By: A. Bharadwaj*, J. Kovar* & M. Simpson

Source: Crossref
Added: January 30, 2021

2004 journal article

Characterization of Human UDP-glucose Dehydrogenase: CYS-276 is required for the second of two successive oxidations

Journal of Biological Chemistry, 279(22), 23590–23596.

By: B. Sommer*, J. Barycki* & M. Simpson

Source: Crossref
Added: August 28, 2020

2004 journal article

Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms

The Journal of Cell Biology, 165(6), 881–891.

By: J. Yang*, M. Price*, C. Neudauer*, C. Wilson*, S. Ferrone*, H. Xia, J. Iida*, M. Simpson, J. McCarthy*

author keywords: melanoma chondroitin sulfate proteoglycan; FAK; integrin; ERK1/2; cell spreading
Source: Crossref
Added: January 30, 2021