Melanie Simpson

Zimmer, B. M., Barycki, J. J., & Simpson, M. A. (2022). [Review of Mechanisms of coordinating hyaluronan and glycosaminoglycan production by nucleotide sugars]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 322(6), C1201–C1213. https://doi.org/10.1152/ajpcell.00130.2022

Zimmer, B. M., Barycki, J. J., & Simpson, M. A. (2021). [Review of Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 69(1), 13–23. https://doi.org/10.1369/0022155420947500

Hengel, H., Bosso-Lefevre, C., Grady, G., Szenker-Ravi, E., Li, H., Pierce, S., … Reversade, B. (2020). Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy. NATURE COMMUNICATIONS, 11(1). https://doi.org/10.1038/s41467-020-14360-7

Nowialis, P., Lopusna, K., Opayska, J., Haney, S. L., Abraham, A., Sheng, P., … Opaysky, R. (2019). Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions. NATURE COMMUNICATIONS, 10. https://doi.org/10.1038/s41467-019-12355-7

McAtee, C. O., Booth, C., Elowsky, C., Zhao, L., Payne, J., Fangman, T., … Simpson, M. A. (2019). Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling. MATRIX BIOLOGY, 78-79, 165–179. https://doi.org/10.1016/j.matbio.2018.05.002

Grady, G., Thelen, A., Albers, J., Ju, T., Guo, J., Barycki, J. J., & Simpson, M. A. (2016). Inhibiting Hexamer Disassembly of Human UDP-Glucose Dehydrogenase by Photoactivated Amino Acid Cross-Linking. Biochemistry, 55(22), 3157–3164. https://doi.org/10.1021/ACS.BIOCHEM.6B00259

Zimmer, B. M. ., Howell, M. E., Wei, Q., Ma, L., Romsdahl, T., Loughman, E. G., … Simpson, M. A. (2016). Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential. Hormones and Cancer, 7(4), 260–271. https://doi.org/10.1007/S12672-016-0268-Z

McAtee, C. O., Berkebile, A. R., Elowsky, C. G., Fangman, T., Barycki, J. J., Wahl, J. K., III, … Simpson, M. A. (2015). Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking. Journal of Biological Chemistry, 290(21), 13144–13156. https://doi.org/10.1074/JBC.M115.647446

Haney, S. L., Hlady, R. A., Opavska, J., Klinkebiel, D., Pirruccello, S. J., Dutta, S., … Opavsky, R. (2015). Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis. Oncogene, 34(43), 5436–5446. https://doi.org/10.1038/ONC.2014.472

Peters, S. L., Hlady, R. A., Opavska, J., Klinkebiel, D., Pirruccello, S. J., Talmon, G. A., … Opavsky, R. (2014). Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis. Leukemia, 28(5), 1138–1142. https://doi.org/10.1038/LEU.2013.364

Kovar, J. L., Curtis, E., Othman, S. F., Simpson, M. A., & Michael Olive, D. (2013). Characterization of IRDye 800CW chlorotoxin as a targeting agent for brain tumors. Analytical Biochemistry, 440(2), 212–219. https://doi.org/10.1016/J.AB.2013.05.013

Hyde, A. S., Thelen, A. M., Barycki, J. J., & Simpson, M. A. (2013). UDP-glucose Dehydrogenase Activity and Optimal Downstream Cellular Function Require Dynamic Reorganization at the Dimer-Dimer Subunit Interfaces. Journal of Biological Chemistry, 288(49), 35049–35057. https://doi.org/10.1074/JBC.M113.519090

Stephens, E. H., Saltarrelli Jr, J. G., Balaoing, L. R., Baggett, L. S., Nandi, I., Anderson, K. M., … Grande-Allen, K. J. (2012). Hyaluronan turnover and hypoxic brown adipocytic differentiation are co-localized with ossification in calcified human aortic valves. Pathology - Research and Practice, 208(11), 642–650. https://doi.org/10.1016/j.prp.2012.08.001

Simpson, M. A., Weigel, J. A., & Weigel, P. H. (2012). Systemic blockade of the hyaluronan receptor for endocytosis prevents lymph node metastasis of prostate cancer. International Journal of Cancer, 131(5), E836–E840. https://doi.org/10.1002/ijc.27427

Hyde, A. S., Farmer, E. L., Easley, K. E., van Lammeren, K., Christoffels, V. M., Barycki, J. J., … Simpson, M. A. (2012). UDP-glucose Dehydrogenase Polymorphisms from Patients with Congenital Heart Valve Defects Disrupt Enzyme Stability and Quaternary Assembly. Journal of Biological Chemistry, 287(39), 32708–32716. https://doi.org/10.1074/jbc.M112.395202

Willis, M. N., Liu, Y., Biterova, E. I., Simpson, M. A., Kim, H., Lee, J., & Barycki, J. J. (2011). Enzymatic Defects Underlying Hereditary Glutamate Cysteine Ligase Deficiency Are Mitigated by Association of the Catalytic and Regulatory Subunits. Biochemistry, 50(29), 6508–6517. https://doi.org/10.1021/bi200708w

Bharadwaj, A. G., Goodrich, N. P., McAtee, C. O., Haferbier, K., Oakley, G. G., Wahl, J. K., III, & Simpson, M. A. (2011). Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling. Experimental Cell Research, 317(8), 1214–1225. https://doi.org/10.1016/j.yexcr.2011.01.026

Kovar, J. L., Xu, X., Draney, D., Cupp, A., Simpson, M. A., & Olive, D. M. (2011). Near-infrared-labeled tetracycline derivative is an effective marker of bone deposition in mice. Analytical Biochemistry, 416(2), 167–173. https://doi.org/10.1016/j.ab.2011.05.011

Huang, D., Casale, G. P., Tian, J., Lele, S. M., Pisarev, V. M., Simpson, M. A., & Hemstreet, G. P., III. (2010). Udp-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer. International Journal of Cancer, 126(2), 315–327. https://doi.org/10.1002/ijc.24820

Kovar, J. L., Volcheck, W., Sevick-Muraca, E., Simpson, M. A., & Olive, D. M. (2009). Characterization and performance of a near-infrared 2-deoxyglucose optical imaging agent for mouse cancer models. Analytical Biochemistry, 384(2), 254–262. https://doi.org/10.1016/j.ab.2008.09.050

Zhang, L., Bharadwaj, A. G., Casper, A., Barkley, J., Barycki, J. J., & Simpson, M. A. (2009). Hyaluronidase Activity of Human Hyal1 Requires Active Site Acidic and Tyrosine Residues. Journal of Biological Chemistry, 284(14), 9433–9442. https://doi.org/10.1074/jbc.M900210200

Kovar, J. L., Simpson, M. A., Schutz-Geschwender, A., & Olive, D. M. (2007). A systematic approach to the development of fluorescent contrast agents for optical imaging of mouse cancer models. Analytical Biochemistry, 367(1), 1–12. https://doi.org/10.1016/j.ab.2007.04.011

Easley, K. E., Sommer, B. J., Boanca, G., Barycki, J. J., & Simpson, M. A. (2007). Characterization of Human UDP-Glucose Dehydrogenase Reveals Critical Catalytic Roles for Lysine 220 and Aspartate 280. Biochemistry, 46(2), 369–378. https://doi.org/10.1021/bi061537d

Bharadwaj, A. G., Rector, K., & Simpson, M. A. (2007). Inducible Hyaluronan Production Reveals Differential Effects on Prostate Tumor Cell Growth and Tumor Angiogenesis. Journal of Biological Chemistry, 282(28), 20561–20572. https://doi.org/10.1074/jbc.M702964200

Kovar, J. L., Volcheck, W. M., Chen, J., & Simpson, M. A. (2007). Purification method directly influences effectiveness of an epidermal growth factor-coupled targeting agent for noninvasive tumor detection in mice. Analytical Biochemistry, 361(1), 47–54. https://doi.org/10.1016/j.ab.2006.11.021

Bharadwaj, A., Kovar, J., & Simpson, M. (2006). Hyaluronan synthesis and turnover induces metastatic growth. Matrix Biology, 25, S40–S40. https://doi.org/10.1016/j.matbio.2006.08.110

Sommer, B. J., Barycki, J. J., & Simpson, M. A. (2004). Characterization of Human UDP-glucose Dehydrogenase: CYS-276 is required for the second of two successive oxidations. Journal of Biological Chemistry, 279(22), 23590–23596. https://doi.org/10.1074/jbc.M401928200

Yang, J., Price, M. A., Neudauer, C. L., Wilson, C., Ferrone, S., Xia, H., … McCarthy, J. B. (2004). Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms. The Journal of Cell Biology, 165(6), 881–891. https://doi.org/10.1083/jcb.200403174