Works (21)
Updated: July 5th, 2023 15:42
2020 journal article
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
NATURE COMMUNICATIONS, 11(1).
MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Apoptosis / drug effects; Bleomycin / toxicity; Cell Proliferation; Disease Models, Animal; Exosomes / metabolism; Exosomes / transplantation; Humans; Idiopathic Pulmonary Fibrosis / chemically induced; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Idiopathic Pulmonary Fibrosis / therapy; Lung / cytology; Lung / metabolism; Lung Injury / chemically induced; Lung Injury / metabolism; Lung Injury / pathology; Lung Injury / therapy; Mesenchymal Stem Cells / metabolism; Mice; Myofibroblasts / cytology; Proteomics; Silicon Dioxide / toxicity; Spheroids, Cellular / metabolism
TL;DR:
It is shown that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells.
(via Semantic Scholar)
www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 23, 2020
2018 journal article
Cardiac cell-integrated microneedle patch for treating myocardial infarction
SCIENCE ADVANCES, 4(11).
MeSH headings : Animals; Cells, Cultured; Microtechnology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Needles; Rats; Rats, Inbred WKY; Regeneration; Stromal Cells / cytology; Stromal Cells / transplantation; Swine; Tissue Engineering / instrumentation
TL;DR:
The microneedle patch integrated with cardiac stromal cells (MN-CSCs) represents an innovative approach delivering therapeutic cells for heart regeneration and polymeric MNs are used to create “channels” between host myocardium and therapeutic CSCs to promote heart repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 31, 2018
2018 journal article
Targeted repair of heart injury by stem cells fused with platelet nanovesicles
NATURE BIOMEDICAL ENGINEERING, 2(1), 17–26.
TL;DR:
The attachment of platelet nanovesicles to the surface of cardiac stem cells increases the retention of the cells delivered to the heart and reduces infarct size in rat and pig models of acute myocardial infarction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide
THERANOSTICS, 8(7), 1869–1878.
author keywords: Targeting; exosomes; cardiac regeneration; heart disease; myocardial infarction
MeSH headings : Administration, Intravenous; Animals; Biological Products / administration & dosage; Biological Products / pharmacokinetics; Biological Therapy / methods; Cell Survival; Disease Models, Animal; Echocardiography; Exosomes; Molecular Targeted Therapy / methods; Myocardial Infarction / therapy; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Peptides / administration & dosage; Peptides / pharmacokinetics; Rats; Treatment Outcome
TL;DR:
By targeting exosomes to the infarcted heart, there was a significant improvement in outcomes with reduced fibrosis and scar size, and increased cellular proliferation and angiogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart
Tissue Engineering Part C: Methods, 23(3), 146–155.
author keywords: cardiac patch; platelet fibrin gel; myocardial infarction; regeneration
MeSH headings : Animals; Biocompatible Materials / chemistry; Blood Platelets / metabolism; Fibrin / metabolism; Heart / physiology; Male; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Paintings; Rats; Rats, Sprague-Dawley; Regeneration / physiology
TL;DR:
The use of the spraying system allowed for placement of a uniform cardiac patch on the heart in a mini-invasive manner without the need for sutures or glue, and promoted cardiac repair and attenuated cardiac dysfunction after MI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2017 journal article
Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies
Respiratory Research, 18(1).
author keywords: Pulmonary progenitor cells; Lung spheroid; Stem cell
MeSH headings : Adolescent; Aged; Animals; Biopsy; Bronchi / cytology; Bronchi / physiology; Cell Culture Techniques / methods; Female; Human Umbilical Vein Endothelial Cells / physiology; Humans; Infusions, Intravenous; Lung / cytology; Lung / physiology; Male; Mice; Mice, Nude; Middle Aged; Spheroids, Cellular / physiology; Stem Cell Transplantation / methods; Stem Cells / physiology
TL;DR:
These cells could be utilized in long-term expansion of lung progenitor cells and as part of the development of cell-based therapies for the treatment of lung diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2017 journal article
Heart Repair Using Nanogel-Encapsulated Human Cardiac Stem Cells in Mice and Pigs with Myocardial Infarction
ACS NANO, 11(10), 9738–9749.
author keywords: cardiac stem cells; nanogel; myocardial infarction; biomaterials; mouse model; pig model
MeSH headings : Acrylamides / chemistry; Acrylates / chemistry; Animals; Disease Models, Animal; Female; Humans; Mice; Myocardial Infarction / metabolism; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Nanogels; Particle Size; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Surface Properties; Swine; Temperature
TL;DR:
In mice and pigs with acute MI, injection of encapsulated hCSCs preserves cardiac function and reduces scar sizes, whereas injection of hC SCs in saline has an adverse effect on heart healing, suggesting thermosensitive nanogels can be used as a stem cell carrier.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy
Journal of Cellular and Molecular Medicine, 21(8), 1503–1512.
author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy; allogeneic
MeSH headings : Animals; Biomarkers / metabolism; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / immunology; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / therapy; Coronary Vessels / cytology; Coronary Vessels / immunology; Dogs; Echocardiography; Endoglin / genetics; Endoglin / immunology; Female; Gene Expression; Humans; Male; Myocardium / immunology; Myocardium / pathology; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / immunology; Spheroids, Cellular / cytology; Spheroids, Cellular / immunology; Spheroids, Cellular / transplantation; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / immunology; Thy-1 Antigens / genetics; Thy-1 Antigens / immunology; Transplantation, Homologous
TL;DR:
The safety and efficacy of allogeneic CDC in a large animal (canine) model of spontaneous DCM and Histology on dog hearts revealed no sign of immune rejection from the transplanted cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2017 journal article
Safety and Efficacy of Allogeneic Lung Spheroid Cells in a Mismatched Rat Model of Pulmonary Fibrosis
STEM CELLS Translational Medicine, 6(10), 1905–1916.
author keywords: Fibrosis; Pulmonary; Syngeneic; Allogeneic; Stem cells
MeSH headings : Animals; Bleomycin / toxicity; Cells, Cultured; Female; Lung / cytology; Pulmonary Fibrosis / etiology; Pulmonary Fibrosis / therapy; Rats; Rats, Wistar; Spheroids, Cellular / transplantation; Stem Cell Transplantation / adverse effects; Stem Cell Transplantation / methods; Transplantation, Homologous / adverse effects; Transplantation, Homologous / methods
TL;DR:
It is found that infusion of allogeneic LSCs reduces the progression of inflammation and fibrotic manifestation and preserves epithelial and endothelial health without eliciting significant immune rejection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2017 journal article
Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome
Nature Communications, 8(1).
MeSH headings : Animals; Biomimetic Materials / chemistry; Biomimetic Materials / metabolism; Biomimetic Materials / pharmacology; Cell Fractionation; Cell Membrane / chemistry; Cell Membrane / metabolism; Cell Membrane / transplantation; Cell-Derived Microparticles / chemistry; Cell-Derived Microparticles / metabolism; Cell-Derived Microparticles / transplantation; Culture Media, Conditioned / chemistry; Culture Media, Conditioned / isolation & purification; Disease Models, Animal; Gene Expression; Hepatocyte Growth Factor / genetics; Hepatocyte Growth Factor / metabolism; Humans; Injections, Intralesional; Insulin-Like Growth Factor I / genetics; Insulin-Like Growth Factor I / metabolism; Intercellular Signaling Peptides and Proteins / pharmacology; Male; Mice; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / metabolism; Myocardium / pathology; Paracrine Communication; Recovery of Function / drug effects; Stem Cells / cytology; Stem Cells / metabolism; Vascular Endothelial Growth Factor A / genetics; Vascular Endothelial Growth Factor A / metabolism
TL;DR:
A synthetic cell-mimicking microparticle that recapitulates stem cell functions in tissue repair and acts as ‘synthetic stem cells’ which mimic the paracrine and biointerfacing activities of natural stem cells in therapeutic cardiac regeneration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2016 journal article
Angiopellosis as an Alternative Mechanism of Cell Extravasation
STEM CELLS, 35(1), 170–180.
author keywords: Extravasation; Angiopellosis; Transmigration; Stem cell infusion; Diapedesis
MeSH headings : Animals; Blood Vessels / physiology; CD11 Antigens / metabolism; Cell Aggregation; Cell Membrane / metabolism; Cell Shape; Dogs; Extravasation of Diagnostic and Therapeutic Materials / pathology; Female; Humans; Injections; Intravital Microscopy; Male; Mesenchymal Stem Cells; Microspheres; Myocytes, Cardiac / cytology; Polymers / chemistry; Rats; Time Factors; Transendothelial and Transepithelial Migration; Zebrafish / metabolism
TL;DR:
In injected cardiac and mesenchymal stem cells, the vascular wall undergoes an extensive remodeling to allow the cell to exit the lumen, while the injected cell remains distinctively passive in activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Effects of Matrix Metalloproteinases on the Performance of Platelet Fibrin Gel Spiked With Cardiac Stem Cells in Heart Repair
STEM CELLS TRANSLATIONAL MEDICINE, 5(6), 793–803.
author keywords: Cardiac stem cells; Platelet fibrin gel; Matrix metalloproteinases; Heart repair
MeSH headings : Animals; Blood Platelets / metabolism; Dipeptides / administration & dosage; Disease Models, Animal; Echocardiography; Fibrin / administration & dosage; Humans; Matrix Metalloproteinase Inhibitors / administration & dosage; Matrix Metalloproteinases / metabolism; Myocardial Infarction / enzymology; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / metabolism; Rats; Regeneration / drug effects; Stem Cell Transplantation
TL;DR:
It is suggested that MMPs play a critical role in the therapeutic benefits of platelet fibrin gel spiked with cardiac stem cells for treating MI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents With Bleomycin-Induced Pulmonary Fibrosis
STEM CELLS TRANSLATIONAL MEDICINE, 4(11), 1265–1274.
author keywords: Adult lung stem cells; Mesenchymal stem cells; Pulmonary fibrosis; Spheroid cell culture
MeSH headings : Adult; Animals; Antibiotics, Antineoplastic / adverse effects; Antibiotics, Antineoplastic / pharmacology; Bleomycin / adverse effects; Bleomycin / pharmacology; Female; Heterografts; Humans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells / metabolism; Mesenchymal Stem Cells / pathology; Mice; Mice, SCID; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / metabolism; Pulmonary Fibrosis / pathology; Pulmonary Fibrosis / therapy; Regeneration; Spheroids, Cellular / metabolism; Spheroids, Cellular / transplantation
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts
Journal of Cellular and Molecular Medicine, 19(8), 1805–1813.
author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy
MeSH headings : Aging; Animals; Apoptosis; Cell Differentiation; Cells, Cultured; Dogs; Female; Fibrosis; Heart / physiology; Heart Function Tests; Mice, SCID; Myocardium / pathology; Myocytes, Cardiac / cytology; Neovascularization, Physiologic; Paracrine Communication; Regeneration; Spheroids, Cellular / cytology
TL;DR:
It is shown that canine CDCs can be produced from adult dog hearts and display similar phenotypes in comparison to previously studied CDCs derived from rodents and human beings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2015 chapter
Cryopreservation of Neonatal Cardiomyocytes
In Methods in Molecular Biology (Vol. 1299, pp. 153–160).
author keywords: Cardiomyocytes; Cryopreservation; Cardiac research
MeSH headings : Animals; Animals, Newborn; Cell Culture Techniques; Cells, Cultured; Cryopreservation / methods; Myocytes, Cardiac / cytology; Rats
TL;DR:
A method for cryopreserving neonatal rat cardiomyocytes (NRCMs), and subsequently thawing them for use in assays and to reduce the time requirements and the impact on research animals is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2015 journal article
Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy
Stem Cells International, 2015, 1–8.
TL;DR:
Mice receiving CSC-XOs showed improved heart function via echocardiography, as well as decreased apoptosis and fibrosis, and mice showed no adverse immune reaction, showing promise for overcoming the limitations of stem cells and improving cardiac therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2015 journal article
Isolation and Cryopreservation of Neonatal Rat Cardiomyocytes
Journal of Visualized Experiments, (98).
author keywords: Developmental Biology; Issue 98; Cryopreservation; Cardiomyocytes; Cell-based Assay; Cell Culture; Cardiac Research; In Vitro Assay
MeSH headings : Actinin / analysis; Actinin / metabolism; Animals; Animals, Newborn; Cell Culture Techniques; Cell Separation / methods; Cell Survival / physiology; Cryopreservation / methods; Cryoprotective Agents / chemistry; Dimethyl Sulfoxide / chemistry; Freezing; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Rats; Sarcomeres / chemistry; Sarcomeres / metabolism
TL;DR:
Cryopreservation methods allow one to easily cryopreserve and thaw neonatal rat cardiomyocytes, which gives researchers a greater amount of flexibility in planning experiments as well as reducing the use of animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2015 journal article
Rapid and Efficient Production of Coronary Artery Ligation and Myocardial Infarction in Mice Using Surgical Clips
PLOS ONE, 10(11).
MeSH headings : Animals; Coronary Vessels / surgery; Disease Models, Animal; Ligation; Mice; Myocardial Infarction / etiology; Myocardial Infarction / mortality; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Surgical Instruments; Suture Techniques; Vascular Surgical Procedures
TL;DR:
This new method, taking only less than 3 minutes to complete, represents an efficient myocardial infarction model in rodents and improved post-MI survival rate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting
Nature Communications, 5(1).
MeSH headings : Animals; Antibodies; Bone Marrow Cells / metabolism; Bone Marrow Transplantation / methods; Cell Movement; Ferrosoferric Oxide / therapeutic use; Iron; Leukocytes, Mononuclear / metabolism; Magnets; Myocardial Infarction / therapy; Myocytes, Cardiac / metabolism; Nanotechnology / methods; Rats; Regeneration; Stem Cells
TL;DR:
The authors use magnetic iron nanoparticles conjugated with antibodies that bind therapeutic cells and cardiomyocytes to treat myocardial ischemia/reperfusion injury in rats and show that targeting to the heart is enhanced upon local application of a magnetic field.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2014 journal article
Magnetic targeting of cardiosphere-derived stem cells with ferumoxytol nanoparticles for treating rats with myocardial infarction
BIOMATERIALS, 35(30), 8528–8539.
author keywords: Cardiac stem cells; Magnetic targeting; Myocardial infarction; Ferumoxytol; MRI; Superparamagnetic iron oxide nanoparticles
MeSH headings : Animals; Apoptosis / drug effects; Cell Movement / drug effects; Cell Proliferation / drug effects; Cell Survival / drug effects; Female; Ferrosoferric Oxide / pharmacology; Ferrosoferric Oxide / therapeutic use; Finite Element Analysis; Heart Function Tests; Heparin / pharmacology; Humans; Inflammation / pathology; Iron Overload / pathology; Magnetic Phenomena; Male; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / pathology; Nanoparticles / therapeutic use; Nanoparticles / ultrastructure; Neovascularization, Physiologic / drug effects; Protamines / pharmacology; Rats; Rats, Inbred WKY; Spheroids, Cellular / drug effects; Spheroids, Cellular / pathology
TL;DR:
FHP labeling is safe to cardiac stem cells and facilitates magnetically-targeted stem cell delivery into the heart which leads to augmented cell engraftment and therapeutic benefit, and magnetic targeting increased cardiac retention of transplanted FHP-rCDCs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Relative Roles of CD90 and c-Kit to the Regenerative Efficacy of Cardiosphere-Derived Cells in Humans and in a Mouse Model of Myocardial Infarction
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 3(5).
author keywords: cardiosphere-derived cells; CD90; ckit; myocardial infarction
MeSH headings : Analysis of Variance; Animals; Apoptosis / physiology; Biomarkers / analysis; Cell Differentiation / physiology; Cell Transplantation / methods; Cells, Cultured; Disease Models, Animal; Heart Function Tests; Humans; Male; Mice; Mice, SCID; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / transplantation; Prospective Studies; Proto-Oncogene Proteins c-kit / metabolism; Regeneration / physiology; Role; Sensitivity and Specificity; Thy-1 Antigens / metabolism; Treatment Outcome
TL;DR:
It is shown, surprisingly, that c‐kit expression has no relationship to CDCs' therapeutic efficacy in humans, and depletion of c‐Kit+ cells does not undermine the structural and functional benefits of CDCs in a mouse model of myocardial infarction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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